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Q15543

- TAF13_HUMAN

UniProt

Q15543 - TAF13_HUMAN

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Protein

Transcription initiation factor TFIID subunit 13

Gene

TAF13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

TFIID beta-specific TAFII.

GO - Molecular functioni

  1. DNA binding Source: Ensembl
  2. protein C-terminus binding Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB

GO - Biological processi

  1. DNA-templated transcription, initiation Source: UniProtKB
  2. gene expression Source: Reactome
  3. transcription elongation from RNA polymerase II promoter Source: Reactome
  4. transcription from RNA polymerase II promoter Source: UniProtKB
  5. transcription initiation from RNA polymerase II promoter Source: UniProtKB
  6. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_6233. Transcription of the HIV genome.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6332. HIV Transcription Initiation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 13
Alternative name(s):
Transcription initiation factor TFIID 18 kDa subunit
Short name:
TAF(II)18
Short name:
TAFII-18
Short name:
TAFII18
Gene namesi
Name:TAF13
Synonyms:TAF2K, TAFII18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11546. TAF13.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: HPA
  2. nucleoplasm Source: Reactome
  3. nucleus Source: HPA
  4. transcription factor TFIID complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 124124Transcription initiation factor TFIID subunit 13PRO_0000118910Add
BLAST

Proteomic databases

MaxQBiQ15543.
PRIDEiQ15543.

PTM databases

PhosphoSiteiQ15543.

Expressioni

Gene expression databases

BgeeiQ15543.
CleanExiHS_TAF13.
GenevestigatoriQ15543.

Organism-specific databases

HPAiHPA044492.

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
TAF11Q155442EBI-1026992,EBI-1027005

Protein-protein interaction databases

BioGridi112747. 21 interactions.
DIPiDIP-900N.
IntActiQ15543. 2 interactions.
MINTiMINT-1537430.
STRINGi9606.ENSP00000355051.

Structurei

Secondary structure

1
124
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 4210
Helixi51 – 7424

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BH8X-ray3.00A31-75[»]
1BH9X-ray2.60A31-75[»]
ProteinModelPortaliQ15543.
SMRiQ15543. Positions 31-75.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15543.

Family & Domainsi

Domaini

The binding of TAF10 and TAF11 requires distinct domains of TAF13.

Sequence similaritiesi

Belongs to the TAF13 family.Curated
Contains 1 histone-fold domain.Curated

Phylogenomic databases

eggNOGiCOG5248.
GeneTreeiENSGT00390000012981.
HOGENOMiHOG000237827.
HOVERGENiHBG055385.
InParanoidiQ15543.
KOiK03127.
OMAiKYARVKD.
OrthoDBiEOG773XJ8.
PhylomeDBiQ15543.
TreeFamiTF323609.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003195. TFIID-18.
[Graphical view]
PANTHERiPTHR11380. PTHR11380. 1 hit.
PfamiPF02269. TFIID-18kDa. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15543-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADEEEDPTF EEENEEIGGG AEGGQGKRKR LFSKELRCMM YGFGDDQNPY
60 70 80 90 100
TESVDILEDL VIEFITEMTH KAMSIGRQGR VQVEDIVFLI RKDPRKFARV
110 120
KDLLTMNEEL KRARKAFDEA NYGS
Length:124
Mass (Da):14,287
Last modified:November 1, 1996 - v1
Checksum:i98B62FF1BC8E7B77
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84003 mRNA. Translation: CAA58827.1.
AK312158 mRNA. Translation: BAG35092.1.
BX679664 Genomic DNA. Translation: CAH71330.1.
CH471122 Genomic DNA. Translation: EAW56354.1.
BC121180 mRNA. Translation: AAI21181.1.
CCDSiCCDS30788.1.
PIRiS54782.
RefSeqiNP_005636.1. NM_005645.3.
UniGeneiHs.632426.

Genome annotation databases

EnsembliENST00000338366; ENSP00000355051; ENSG00000197780.
ENST00000461096; ENSP00000433883; ENSG00000197780.
GeneIDi6884.
KEGGihsa:6884.
UCSCiuc001dwm.1. human.

Polymorphism databases

DMDMi3024706.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X84003 mRNA. Translation: CAA58827.1 .
AK312158 mRNA. Translation: BAG35092.1 .
BX679664 Genomic DNA. Translation: CAH71330.1 .
CH471122 Genomic DNA. Translation: EAW56354.1 .
BC121180 mRNA. Translation: AAI21181.1 .
CCDSi CCDS30788.1.
PIRi S54782.
RefSeqi NP_005636.1. NM_005645.3.
UniGenei Hs.632426.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1BH8 X-ray 3.00 A 31-75 [» ]
1BH9 X-ray 2.60 A 31-75 [» ]
ProteinModelPortali Q15543.
SMRi Q15543. Positions 31-75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112747. 21 interactions.
DIPi DIP-900N.
IntActi Q15543. 2 interactions.
MINTi MINT-1537430.
STRINGi 9606.ENSP00000355051.

PTM databases

PhosphoSitei Q15543.

Polymorphism databases

DMDMi 3024706.

Proteomic databases

MaxQBi Q15543.
PRIDEi Q15543.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000338366 ; ENSP00000355051 ; ENSG00000197780 .
ENST00000461096 ; ENSP00000433883 ; ENSG00000197780 .
GeneIDi 6884.
KEGGi hsa:6884.
UCSCi uc001dwm.1. human.

Organism-specific databases

CTDi 6884.
GeneCardsi GC01M109605.
HGNCi HGNC:11546. TAF13.
HPAi HPA044492.
MIMi 600774. gene.
neXtProti NX_Q15543.
PharmGKBi PA36321.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5248.
GeneTreei ENSGT00390000012981.
HOGENOMi HOG000237827.
HOVERGENi HBG055385.
InParanoidi Q15543.
KOi K03127.
OMAi KYARVKD.
OrthoDBi EOG773XJ8.
PhylomeDBi Q15543.
TreeFami TF323609.

Enzyme and pathway databases

Reactomei REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_6233. Transcription of the HIV genome.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6332. HIV Transcription Initiation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

EvolutionaryTracei Q15543.
GeneWikii TAF13.
GenomeRNAii 6884.
NextBioi 26895.
PROi Q15543.
SOURCEi Search...

Gene expression databases

Bgeei Q15543.
CleanExi HS_TAF13.
Genevestigatori Q15543.

Family and domain databases

Gene3Di 1.10.20.10. 1 hit.
InterProi IPR009072. Histone-fold.
IPR003195. TFIID-18.
[Graphical view ]
PANTHERi PTHR11380. PTHR11380. 1 hit.
Pfami PF02269. TFIID-18kDa. 1 hit.
[Graphical view ]
SUPFAMi SSF47113. SSF47113. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID."
    Mengus G., May M., Jacq X., Staub A., Tora L., Chambon P., Davidson I.
    EMBO J. 14:1520-1531(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Substantia nigra.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family."
    Birck C., Poch O., Romier C., Ruff M., Mengus G., Lavigne A.C., Davidson I., Moras D.
    Cell 94:239-249(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 31-75 IN COMPLEX WITH TAF11.

Entry informationi

Entry nameiTAF13_HUMAN
AccessioniPrimary (citable) accession number: Q15543
Secondary accession number(s): B2R5E5, Q5TYV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3