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Q15543

- TAF13_HUMAN

UniProt

Q15543 - TAF13_HUMAN

Protein

Transcription initiation factor TFIID subunit 13

Gene

TAF13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    TFIID beta-specific TAFII.

    GO - Molecular functioni

    1. DNA binding Source: Ensembl
    2. protein binding Source: UniProtKB
    3. protein C-terminus binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB

    GO - Biological processi

    1. DNA-templated transcription, initiation Source: UniProtKB
    2. gene expression Source: Reactome
    3. transcription elongation from RNA polymerase II promoter Source: Reactome
    4. transcription from RNA polymerase II promoter Source: UniProtKB
    5. transcription initiation from RNA polymerase II promoter Source: UniProtKB
    6. viral process Source: Reactome

    Keywords - Biological processi

    Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_1851. RNA Polymerase II Transcription Initiation.
    REACT_2089. RNA Polymerase II Promoter Escape.
    REACT_22107. RNA Polymerase II Pre-transcription Events.
    REACT_6233. Transcription of the HIV genome.
    REACT_6253. RNA Polymerase II HIV Promoter Escape.
    REACT_6332. HIV Transcription Initiation.
    REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Transcription initiation factor TFIID subunit 13
    Alternative name(s):
    Transcription initiation factor TFIID 18 kDa subunit
    Short name:
    TAF(II)18
    Short name:
    TAFII-18
    Short name:
    TAFII18
    Gene namesi
    Name:TAF13
    Synonyms:TAF2K, TAFII18
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11546. TAF13.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: HPA
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HPA
    4. transcription factor TFIID complex Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36321.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 124124Transcription initiation factor TFIID subunit 13PRO_0000118910Add
    BLAST

    Proteomic databases

    MaxQBiQ15543.
    PRIDEiQ15543.

    PTM databases

    PhosphoSiteiQ15543.

    Expressioni

    Gene expression databases

    BgeeiQ15543.
    CleanExiHS_TAF13.
    GenevestigatoriQ15543.

    Organism-specific databases

    HPAiHPA044492.

    Interactioni

    Subunit structurei

    TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TAF11Q155442EBI-1026992,EBI-1027005

    Protein-protein interaction databases

    BioGridi112747. 21 interactions.
    DIPiDIP-900N.
    IntActiQ15543. 2 interactions.
    MINTiMINT-1537430.
    STRINGi9606.ENSP00000355051.

    Structurei

    Secondary structure

    1
    124
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi33 – 4210
    Helixi51 – 7424

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1BH8X-ray3.00A31-75[»]
    1BH9X-ray2.60A31-75[»]
    ProteinModelPortaliQ15543.
    SMRiQ15543. Positions 31-75.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15543.

    Family & Domainsi

    Domaini

    The binding of TAF10 and TAF11 requires distinct domains of TAF13.

    Sequence similaritiesi

    Belongs to the TAF13 family.Curated
    Contains 1 histone-fold domain.Curated

    Phylogenomic databases

    eggNOGiCOG5248.
    HOGENOMiHOG000237827.
    HOVERGENiHBG055385.
    InParanoidiQ15543.
    KOiK03127.
    OMAiKYARVKD.
    OrthoDBiEOG773XJ8.
    PhylomeDBiQ15543.
    TreeFamiTF323609.

    Family and domain databases

    Gene3Di1.10.20.10. 1 hit.
    InterProiIPR009072. Histone-fold.
    IPR003195. TFIID-18.
    [Graphical view]
    PANTHERiPTHR11380. PTHR11380. 1 hit.
    PfamiPF02269. TFIID-18kDa. 1 hit.
    [Graphical view]
    SUPFAMiSSF47113. SSF47113. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q15543-1 [UniParc]FASTAAdd to Basket

    « Hide

    MADEEEDPTF EEENEEIGGG AEGGQGKRKR LFSKELRCMM YGFGDDQNPY    50
    TESVDILEDL VIEFITEMTH KAMSIGRQGR VQVEDIVFLI RKDPRKFARV 100
    KDLLTMNEEL KRARKAFDEA NYGS 124
    Length:124
    Mass (Da):14,287
    Last modified:November 1, 1996 - v1
    Checksum:i98B62FF1BC8E7B77
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84003 mRNA. Translation: CAA58827.1.
    AK312158 mRNA. Translation: BAG35092.1.
    BX679664 Genomic DNA. Translation: CAH71330.1.
    CH471122 Genomic DNA. Translation: EAW56354.1.
    BC121180 mRNA. Translation: AAI21181.1.
    CCDSiCCDS30788.1.
    PIRiS54782.
    RefSeqiNP_005636.1. NM_005645.3.
    UniGeneiHs.632426.

    Genome annotation databases

    EnsembliENST00000338366; ENSP00000355051; ENSG00000197780.
    ENST00000461096; ENSP00000433883; ENSG00000197780.
    GeneIDi6884.
    KEGGihsa:6884.
    UCSCiuc001dwm.1. human.

    Polymorphism databases

    DMDMi3024706.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X84003 mRNA. Translation: CAA58827.1 .
    AK312158 mRNA. Translation: BAG35092.1 .
    BX679664 Genomic DNA. Translation: CAH71330.1 .
    CH471122 Genomic DNA. Translation: EAW56354.1 .
    BC121180 mRNA. Translation: AAI21181.1 .
    CCDSi CCDS30788.1.
    PIRi S54782.
    RefSeqi NP_005636.1. NM_005645.3.
    UniGenei Hs.632426.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1BH8 X-ray 3.00 A 31-75 [» ]
    1BH9 X-ray 2.60 A 31-75 [» ]
    ProteinModelPortali Q15543.
    SMRi Q15543. Positions 31-75.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112747. 21 interactions.
    DIPi DIP-900N.
    IntActi Q15543. 2 interactions.
    MINTi MINT-1537430.
    STRINGi 9606.ENSP00000355051.

    PTM databases

    PhosphoSitei Q15543.

    Polymorphism databases

    DMDMi 3024706.

    Proteomic databases

    MaxQBi Q15543.
    PRIDEi Q15543.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000338366 ; ENSP00000355051 ; ENSG00000197780 .
    ENST00000461096 ; ENSP00000433883 ; ENSG00000197780 .
    GeneIDi 6884.
    KEGGi hsa:6884.
    UCSCi uc001dwm.1. human.

    Organism-specific databases

    CTDi 6884.
    GeneCardsi GC01M109605.
    HGNCi HGNC:11546. TAF13.
    HPAi HPA044492.
    MIMi 600774. gene.
    neXtProti NX_Q15543.
    PharmGKBi PA36321.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5248.
    HOGENOMi HOG000237827.
    HOVERGENi HBG055385.
    InParanoidi Q15543.
    KOi K03127.
    OMAi KYARVKD.
    OrthoDBi EOG773XJ8.
    PhylomeDBi Q15543.
    TreeFami TF323609.

    Enzyme and pathway databases

    Reactomei REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_1851. RNA Polymerase II Transcription Initiation.
    REACT_2089. RNA Polymerase II Promoter Escape.
    REACT_22107. RNA Polymerase II Pre-transcription Events.
    REACT_6233. Transcription of the HIV genome.
    REACT_6253. RNA Polymerase II HIV Promoter Escape.
    REACT_6332. HIV Transcription Initiation.
    REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

    Miscellaneous databases

    EvolutionaryTracei Q15543.
    GeneWikii TAF13.
    GenomeRNAii 6884.
    NextBioi 26895.
    PROi Q15543.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15543.
    CleanExi HS_TAF13.
    Genevestigatori Q15543.

    Family and domain databases

    Gene3Di 1.10.20.10. 1 hit.
    InterProi IPR009072. Histone-fold.
    IPR003195. TFIID-18.
    [Graphical view ]
    PANTHERi PTHR11380. PTHR11380. 1 hit.
    Pfami PF02269. TFIID-18kDa. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47113. SSF47113. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID."
      Mengus G., May M., Jacq X., Staub A., Tora L., Chambon P., Davidson I.
      EMBO J. 14:1520-1531(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Substantia nigra.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family."
      Birck C., Poch O., Romier C., Ruff M., Mengus G., Lavigne A.C., Davidson I., Moras D.
      Cell 94:239-249(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 31-75 IN COMPLEX WITH TAF11.

    Entry informationi

    Entry nameiTAF13_HUMAN
    AccessioniPrimary (citable) accession number: Q15543
    Secondary accession number(s): B2R5E5, Q5TYV6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 134 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3