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Protein

Transcription initiation factor TFIID subunit 13

Gene

TAF13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

TFIID beta-specific TAFII.

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • protein C-terminus binding Source: UniProtKB
  • sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • transcription cofactor activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_6233. Transcription of the HIV genome.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6332. HIV Transcription Initiation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 13
Alternative name(s):
Transcription initiation factor TFIID 18 kDa subunit
Short name:
TAF(II)18
Short name:
TAFII-18
Short name:
TAFII18
Gene namesi
Name:TAF13
Synonyms:TAF2K, TAFII18
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11546. TAF13.

Subcellular locationi

GO - Cellular componenti

  • nucleolus Source: HPA
  • nucleoplasm Source: Reactome
  • nucleus Source: HPA
  • transcription factor TFIID complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36321.

Polymorphism and mutation databases

BioMutaiTAF13.
DMDMi3024706.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 124124Transcription initiation factor TFIID subunit 13PRO_0000118910Add
BLAST

Proteomic databases

MaxQBiQ15543.
PRIDEiQ15543.

PTM databases

PhosphoSiteiQ15543.

Expressioni

Gene expression databases

BgeeiQ15543.
CleanExiHS_TAF13.
ExpressionAtlasiQ15543. baseline and differential.
GenevisibleiQ15543. HS.

Organism-specific databases

HPAiHPA044492.

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
MTUS2Q5JR593EBI-1026992,EBI-742948
TAF11Q155442EBI-1026992,EBI-1027005

Protein-protein interaction databases

BioGridi112747. 22 interactions.
DIPiDIP-900N.
IntActiQ15543. 3 interactions.
MINTiMINT-1537430.
STRINGi9606.ENSP00000355051.

Structurei

Secondary structure

1
124
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi33 – 4210Combined sources
Helixi51 – 7424Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BH8X-ray3.00A31-75[»]
1BH9X-ray2.60A31-75[»]
ProteinModelPortaliQ15543.
SMRiQ15543. Positions 31-75.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15543.

Family & Domainsi

Domaini

The binding of TAF10 and TAF11 requires distinct domains of TAF13.

Sequence similaritiesi

Belongs to the TAF13 family.Curated
Contains 1 histone-fold domain.Curated

Phylogenomic databases

eggNOGiCOG5248.
GeneTreeiENSGT00390000012981.
HOGENOMiHOG000237827.
HOVERGENiHBG055385.
InParanoidiQ15543.
KOiK03127.
OMAiEDIIFLV.
OrthoDBiEOG773XJ8.
PhylomeDBiQ15543.
TreeFamiTF323609.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003195. TFIID-18.
[Graphical view]
PANTHERiPTHR11380. PTHR11380. 1 hit.
PfamiPF02269. TFIID-18kDa. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEEEDPTF EEENEEIGGG AEGGQGKRKR LFSKELRCMM YGFGDDQNPY
60 70 80 90 100
TESVDILEDL VIEFITEMTH KAMSIGRQGR VQVEDIVFLI RKDPRKFARV
110 120
KDLLTMNEEL KRARKAFDEA NYGS
Length:124
Mass (Da):14,287
Last modified:November 1, 1996 - v1
Checksum:i98B62FF1BC8E7B77
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84003 mRNA. Translation: CAA58827.1.
AK312158 mRNA. Translation: BAG35092.1.
BX679664 Genomic DNA. Translation: CAH71330.1.
CH471122 Genomic DNA. Translation: EAW56354.1.
BC121180 mRNA. Translation: AAI21181.1.
CCDSiCCDS30788.1.
PIRiS54782.
RefSeqiNP_005636.1. NM_005645.3.
UniGeneiHs.632426.

Genome annotation databases

EnsembliENST00000338366; ENSP00000355051; ENSG00000197780.
ENST00000461096; ENSP00000433883; ENSG00000197780.
GeneIDi6884.
KEGGihsa:6884.
UCSCiuc001dwm.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84003 mRNA. Translation: CAA58827.1.
AK312158 mRNA. Translation: BAG35092.1.
BX679664 Genomic DNA. Translation: CAH71330.1.
CH471122 Genomic DNA. Translation: EAW56354.1.
BC121180 mRNA. Translation: AAI21181.1.
CCDSiCCDS30788.1.
PIRiS54782.
RefSeqiNP_005636.1. NM_005645.3.
UniGeneiHs.632426.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1BH8X-ray3.00A31-75[»]
1BH9X-ray2.60A31-75[»]
ProteinModelPortaliQ15543.
SMRiQ15543. Positions 31-75.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112747. 22 interactions.
DIPiDIP-900N.
IntActiQ15543. 3 interactions.
MINTiMINT-1537430.
STRINGi9606.ENSP00000355051.

PTM databases

PhosphoSiteiQ15543.

Polymorphism and mutation databases

BioMutaiTAF13.
DMDMi3024706.

Proteomic databases

MaxQBiQ15543.
PRIDEiQ15543.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000338366; ENSP00000355051; ENSG00000197780.
ENST00000461096; ENSP00000433883; ENSG00000197780.
GeneIDi6884.
KEGGihsa:6884.
UCSCiuc001dwm.1. human.

Organism-specific databases

CTDi6884.
GeneCardsiGC01M109605.
HGNCiHGNC:11546. TAF13.
HPAiHPA044492.
MIMi600774. gene.
neXtProtiNX_Q15543.
PharmGKBiPA36321.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5248.
GeneTreeiENSGT00390000012981.
HOGENOMiHOG000237827.
HOVERGENiHBG055385.
InParanoidiQ15543.
KOiK03127.
OMAiEDIIFLV.
OrthoDBiEOG773XJ8.
PhylomeDBiQ15543.
TreeFamiTF323609.

Enzyme and pathway databases

ReactomeiREACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_6233. Transcription of the HIV genome.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6332. HIV Transcription Initiation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

ChiTaRSiTAF13. human.
EvolutionaryTraceiQ15543.
GeneWikiiTAF13.
GenomeRNAii6884.
NextBioi26895.
PROiQ15543.
SOURCEiSearch...

Gene expression databases

BgeeiQ15543.
CleanExiHS_TAF13.
ExpressionAtlasiQ15543. baseline and differential.
GenevisibleiQ15543. HS.

Family and domain databases

Gene3Di1.10.20.10. 1 hit.
InterProiIPR009072. Histone-fold.
IPR003195. TFIID-18.
[Graphical view]
PANTHERiPTHR11380. PTHR11380. 1 hit.
PfamiPF02269. TFIID-18kDa. 1 hit.
[Graphical view]
SUPFAMiSSF47113. SSF47113. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of hTAFII18, hTAFII20 and hTAFII28: three subunits of the human transcription factor TFIID."
    Mengus G., May M., Jacq X., Staub A., Tora L., Chambon P., Davidson I.
    EMBO J. 14:1520-1531(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Substantia nigra.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Human TAF(II)28 and TAF(II)18 interact through a histone fold encoded by atypical evolutionary conserved motifs also found in the SPT3 family."
    Birck C., Poch O., Romier C., Ruff M., Mengus G., Lavigne A.C., Davidson I., Moras D.
    Cell 94:239-249(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 31-75 IN COMPLEX WITH TAF11.

Entry informationi

Entry nameiTAF13_HUMAN
AccessioniPrimary (citable) accession number: Q15543
Secondary accession number(s): B2R5E5, Q5TYV6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: June 24, 2015
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.