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Protein

Transcription initiation factor TFIID subunit 13

Gene

TAF13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the DNA-binding general RNA polymerase II transcription factor IID complex (TFIID). TFIID plays a critical role in the regulation of gene transcription in eukaryotic cells.1 Publication

GO - Molecular functioni

  • DNA binding Source: GO_Central
  • DNA binding transcription factor activity Source: UniProtKB
  • protein C-terminus binding Source: UniProtKB
  • protein heterodimerization activity Source: InterPro
  • transcription cofactor activity Source: GO_Central

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-6807505 RNA polymerase II transcribes snRNA genes
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 13Curated
Alternative name(s):
Transcription initiation factor TFIID 18 kDa subunit1 Publication
Short name:
TAF(II)181 Publication
Short name:
TAFII-18Curated
Short name:
TAFII181 Publication
Gene namesi
Name:TAF13Imported
Synonyms:TAF2KImported, TAFII181 Publication
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000197780.9
HGNCiHGNC:11546 TAF13
MIMi600774 gene
neXtProtiNX_Q15543

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Mental retardation, autosomal recessive 60 (MRT60)1 Publication
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionA disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. In contrast to syndromic or specific mental retardation which also present with associated physical, neurological and/or psychiatric manifestations, intellectual deficiency is the only primary symptom of non-syndromic mental retardation. MRT60 patients display mild intellectual disability, delayed psychomotor development, learning difficulties, and poor overall growth with variable microcephaly. MRT60 inheritance is autosomal recessive.
See also OMIM:617432
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07904631L → H in MRT60; impairs interaction with TAF11. 1 Publication1
Natural variantiVAR_07904740M → K in MRT60; impairs interaction with TAF11. 1 Publication1

Keywords - Diseasei

Disease mutation, Mental retardation

Organism-specific databases

MalaCardsiTAF13
MIMi617432 phenotype
OpenTargetsiENSG00000197780
PharmGKBiPA36321

Polymorphism and mutation databases

BioMutaiTAF13
DMDMi3024706

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001189101 – 124Transcription initiation factor TFIID subunit 13Add BLAST124

Proteomic databases

EPDiQ15543
MaxQBiQ15543
PaxDbiQ15543
PeptideAtlasiQ15543
PRIDEiQ15543

PTM databases

iPTMnetiQ15543
PhosphoSitePlusiQ15543

Expressioni

Gene expression databases

BgeeiENSG00000197780
CleanExiHS_TAF13
ExpressionAtlasiQ15543 baseline and differential
GenevisibleiQ15543 HS

Organism-specific databases

HPAiHPA044492

Interactioni

Subunit structurei

TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). Interacts with TBP, and more strongly with TAF10 and TAF11.1 Publication

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein C-terminus binding Source: UniProtKB
  • protein heterodimerization activity Source: InterPro

Protein-protein interaction databases

BioGridi112747, 28 interactors
CORUMiQ15543
DIPiDIP-900N
IntActiQ15543, 8 interactors
STRINGi9606.ENSP00000355051

Structurei

Secondary structure

1124
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi33 – 42Combined sources10
Helixi51 – 74Combined sources24

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BH8X-ray3.00A31-75[»]
1BH9X-ray2.60A31-75[»]
ProteinModelPortaliQ15543
SMRiQ15543
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15543

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 74Histone-foldSequence analysisAdd BLAST44

Domaini

The binding of TAF10 and TAF11 requires distinct domains of TAF13.1 Publication

Sequence similaritiesi

Belongs to the TAF13 family.Curated

Phylogenomic databases

eggNOGiKOG3901 Eukaryota
COG5248 LUCA
GeneTreeiENSGT00390000012981
HOGENOMiHOG000237827
HOVERGENiHBG055385
InParanoidiQ15543
KOiK03127
OMAiMTHKAME
OrthoDBiEOG091G0VJ8
PhylomeDBiQ15543
TreeFamiTF323609

Family and domain databases

CDDicd07978 TAF13, 1 hit
Gene3Di1.10.20.10, 1 hit
InterProiView protein in InterPro
IPR009072 Histone-fold
IPR003195 TFIID_TAF13
PANTHERiPTHR11380 PTHR11380, 1 hit
PfamiView protein in Pfam
PF02269 TFIID-18kDa, 1 hit
SUPFAMiSSF47113 SSF47113, 1 hit

Sequencei

Sequence statusi: Complete.

Q15543-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEEEDPTF EEENEEIGGG AEGGQGKRKR LFSKELRCMM YGFGDDQNPY
60 70 80 90 100
TESVDILEDL VIEFITEMTH KAMSIGRQGR VQVEDIVFLI RKDPRKFARV
110 120
KDLLTMNEEL KRARKAFDEA NYGS
Length:124
Mass (Da):14,287
Last modified:November 1, 1996 - v1
Checksum:i98B62FF1BC8E7B77
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07904631L → H in MRT60; impairs interaction with TAF11. 1 Publication1
Natural variantiVAR_07904740M → K in MRT60; impairs interaction with TAF11. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X84003 mRNA Translation: CAA58827.1
AK312158 mRNA Translation: BAG35092.1
BX679664 Genomic DNA No translation available.
CH471122 Genomic DNA Translation: EAW56354.1
BC121180 mRNA Translation: AAI21181.1
CCDSiCCDS30788.1
PIRiS54782
RefSeqiNP_005636.1, NM_005645.3
UniGeneiHs.632426

Genome annotation databases

EnsembliENST00000338366; ENSP00000355051; ENSG00000197780
ENST00000461096; ENSP00000433883; ENSG00000197780
GeneIDi6884
KEGGihsa:6884
UCSCiuc001dwm.2 human

Similar proteinsi

Entry informationi

Entry nameiTAF13_HUMAN
AccessioniPrimary (citable) accession number: Q15543
Secondary accession number(s): B2R5E5, Q5TYV6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 167 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

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