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Q15542

- TAF5_HUMAN

UniProt

Q15542 - TAF5_HUMAN

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Protein

Transcription initiation factor TFIID subunit 5

Gene
TAF5, TAF2D
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TAFs components-TIIFD are essential for mediating regulation of RNA polymerase transcription. TAF5/TAFII100 interacts strongly with the histone H4-related TAF6/TAFII80 and the histone H3-related TAF9/TAFII31, as well as a stable complex comprised of both TAF5/TAFII80 and TAF6/TAFII31. Apparently weaker interactions of TAF5/TAFII100 with TBP, TAF1/TAFII250, TAF11/TAFII28, and TAF12/TAFII20, but not TAF7/TAFII55, also have been observed.

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. protein dimerization activity Source: UniProtKB
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  1. chromatin modification Source: UniProtKB
  2. DNA-templated transcription, initiation Source: UniProtKB
  3. gene expression Source: Reactome
  4. histone acetylation Source: GOC
  5. transcription elongation from RNA polymerase II promoter Source: Reactome
  6. transcription from RNA polymerase II promoter Source: Reactome
  7. transcription initiation from RNA polymerase II promoter Source: UniProtKB
  8. viral process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Host-virus interaction, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiREACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_6233. Transcription of the HIV genome.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6332. HIV Transcription Initiation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.
SignaLinkiQ15542.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription initiation factor TFIID subunit 5
Alternative name(s):
Transcription initiation factor TFIID 100 kDa subunit
Short name:
TAF(II)100
Short name:
TAFII-100
Short name:
TAFII100
Gene namesi
Name:TAF5
Synonyms:TAF2D
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 10

Organism-specific databases

HGNCiHGNC:11539. TAF5.

Subcellular locationi

GO - Cellular componenti

  1. actin cytoskeleton Source: HPA
  2. intracellular membrane-bounded organelle Source: HPA
  3. nucleoplasm Source: Reactome
  4. nucleus Source: UniProtKB
  5. transcription factor TFIID complex Source: UniProtKB
  6. transcription factor TFTC complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36314.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 800800Transcription initiation factor TFIID subunit 5PRO_0000051257Add
BLAST

Proteomic databases

MaxQBiQ15542.
PaxDbiQ15542.
PRIDEiQ15542.

PTM databases

PhosphoSiteiQ15542.

Expressioni

Gene expression databases

BgeeiQ15542.
CleanExiHS_TAF5.
GenevestigatoriQ15542.

Organism-specific databases

HPAiHPA006195.
HPA006474.

Interactioni

Subunit structurei

Homodimer. TFIID and PCAF are composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TBP is not part of TFTC. Component of the TFTC-HAT complex, at least composed of TAF5L, TAF6L, TADA3L, SUPT3H/SPT3, TAF2/TAFII150, TAF4/TAFII135, TAF5/TAFII100, GCN5L2/GCN5, TAF10 and TRRAP. Interacts with SV40 Large T antigen.4 Publications

Protein-protein interaction databases

BioGridi112740. 29 interactions.
DIPiDIP-28150N.
IntActiQ15542. 7 interactions.
MINTiMINT-2807293.
STRINGi9606.ENSP00000358854.

Structurei

Secondary structure

1
800
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi198 – 2025
Helixi203 – 2053
Helixi214 – 22613
Helixi230 – 2367
Helixi237 – 2393
Helixi240 – 25314
Helixi257 – 26711
Helixi268 – 2703
Helixi273 – 2753
Helixi276 – 2838
Helixi288 – 2914
Helixi295 – 3006
Helixi302 – 3043
Beta strandi305 – 3106
Helixi311 – 32111
Helixi328 – 3358
Beta strandi338 – 3425

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2NXPX-ray2.17A/B/C/D/E/F/G/H188-343[»]
ProteinModelPortaliQ15542.
SMRiQ15542. Positions 195-343, 436-798.

Miscellaneous databases

EvolutionaryTraceiQ15542.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini92 – 12433LisHAdd
BLAST
Repeati468 – 50740WD 1Add
BLAST
Repeati541 – 58040WD 2Add
BLAST
Repeati583 – 62442WD 3Add
BLAST
Repeati625 – 66642WD 4Add
BLAST
Repeati667 – 70640WD 5Add
BLAST
Repeati709 – 74840WD 6Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi46 – 494Poly-Gly
Compositional biasi399 – 4079Poly-Lys

Domaini

Distinct domains of TAF5/TAFII100 are required for functional interaction with transcription factor TFIIFB (RAP30) and incorporation into the TFIID complex.

Sequence similaritiesi

Belongs to the WD repeat TAF5 family.
Contains 1 LisH domain.
Contains 6 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiCOG2319.
HOVERGENiHBG050226.
InParanoidiQ15542.
KOiK03130.
OMAiRFRIEGR.
OrthoDBiEOG77126F.
PhylomeDBiQ15542.
TreeFamiTF300669.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH_dimerisation.
IPR007582. TFIID-su_WD40-assoc_reg.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF04494. TFIID_90kDa. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view]
PRINTSiPR00320. GPROTEINBRPT.
SMARTiSM00667. LisH. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 2 hits.
PROSITEiPS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform Long (identifier: Q15542-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAALAEEQTE VAVKLEPEGP PTLLPPQAGD GAGEGSGGTT NNGPNGGGGN    50
VAASSSTGGD GGTPKPTVAV SAAAPAGAAP VPAAAPDAGA PHDRQTLLAV 100
LQFLRQSKLR EAEEALRREA GLLEEAVAGS GAPGEVDSAG AEVTSALLSR 150
VTASAPGPAA PDPPGTGASG ATVVSGSASG PAAPGKVGSV AVEDQPDVSA 200
VLSAYNQQGD PTMYEEYYSG LKHFIECSLD CHRAELSQLF YPLFVHMYLE 250
LVYNQHENEA KSFFEKFHGD QECYYQDDLR VLSSLTKKEH MKGNETMLDF 300
RTSKFVLRIS RDSYQLLKRH LQEKQNNQIW NIVQEHLYID IFDGMPRSKQ 350
QIDAMVGSLA GEAKREANKS KVFFGLLKEP EIEVPLDDED EEGENEEGKP 400
KKKKPKKDSI GSKSKKQDPN APPQNRIPLP ELKDSDKLDK IMNMKETTKR 450
VRLGPDCLPS ICFYTFLNAY QGLTAVDVTD DSSLIAGGFA DSTVRVWSVT 500
PKKLRSVKQA SDLSLIDKES DDVLERIMDE KTASELKILY GHSGPVYGAS 550
FSPDRNYLLS SSEDGTVRLW SLQTFTCLVG YKGHNYPVWD TQFSPYGYYF 600
VSGGHDRVAR LWATDHYQPL RIFAGHLADV NCTRFHPNSN YVATGSADRT 650
VRLWDVLNGN CVRIFTGHKG PIHSLTFSPN GRFLATGATD GRVLLWDIGH 700
GLMVGELKGH TDTVCSLRFS RDGEILASGS MDNTVRLWDA IKAFEDLETD 750
DFTTATGHIN LPENSQELLL GTYMTKSTPV VHLHFTRRNL VLAAGAYSPQ 800
Length:800
Mass (Da):86,830
Last modified:May 10, 2005 - v3
Checksum:i87A178BFB7071992
GO
Isoform Short (identifier: Q15542-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     556-610: Missing.

Show »
Length:745
Mass (Da):80,508
Checksum:iE97ADB7163F99617
GO

Sequence cautioni

The sequence AAC50902.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAD97335.1 differs from that shown. Reason: Erroneous initiation.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti130 – 1301S → A.4 Publications
Corresponds to variant rs10883859 [ dbSNP | Ensembl ].
VAR_018462

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei556 – 61055Missing in isoform Short. VSP_006787Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti126 – 1261A → T in CAA64777. 1 Publication
Sequence conflicti126 – 1261A → T in BAD97335. 1 Publication
Sequence conflicti300 – 3001F → L in CAA64777. 1 Publication
Sequence conflicti455 – 4551P → S in CAA64777. 1 Publication
Sequence conflicti469 – 4691A → V in CAA64777. 1 Publication
Sequence conflicti778 – 7781Missing in CAA64777. 1 Publication
Sequence conflicti787 – 7871R → L in AAH52268. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95525 mRNA. Translation: CAA64777.1.
U75309 mRNA. Translation: AAC50902.1. Different initiation.
U80191 mRNA. Translation: AAC51215.1.
AK223615 mRNA. Translation: BAD97335.1. Different initiation.
AK291229 mRNA. Translation: BAF83918.1.
AL591408 Genomic DNA. Translation: CAI16747.1.
CH471066 Genomic DNA. Translation: EAW49645.1.
CH471066 Genomic DNA. Translation: EAW49646.1.
BC052268 mRNA. Translation: AAH52268.2.
BC136340 mRNA. Translation: AAI36341.1.
BC136348 mRNA. Translation: AAI36349.1.
CCDSiCCDS7547.1. [Q15542-1]
RefSeqiNP_008882.2. NM_006951.3. [Q15542-1]
UniGeneiHs.96103.

Genome annotation databases

EnsembliENST00000351396; ENSP00000311024; ENSG00000148835. [Q15542-2]
ENST00000369839; ENSP00000358854; ENSG00000148835. [Q15542-1]
GeneIDi6877.
KEGGihsa:6877.
UCSCiuc001kwv.3. human. [Q15542-1]
uc010qqq.2. human. [Q15542-2]

Polymorphism databases

DMDMi78103206.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95525 mRNA. Translation: CAA64777.1 .
U75309 mRNA. Translation: AAC50902.1 . Different initiation.
U80191 mRNA. Translation: AAC51215.1 .
AK223615 mRNA. Translation: BAD97335.1 . Different initiation.
AK291229 mRNA. Translation: BAF83918.1 .
AL591408 Genomic DNA. Translation: CAI16747.1 .
CH471066 Genomic DNA. Translation: EAW49645.1 .
CH471066 Genomic DNA. Translation: EAW49646.1 .
BC052268 mRNA. Translation: AAH52268.2 .
BC136340 mRNA. Translation: AAI36341.1 .
BC136348 mRNA. Translation: AAI36349.1 .
CCDSi CCDS7547.1. [Q15542-1 ]
RefSeqi NP_008882.2. NM_006951.3. [Q15542-1 ]
UniGenei Hs.96103.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2NXP X-ray 2.17 A/B/C/D/E/F/G/H 188-343 [» ]
ProteinModelPortali Q15542.
SMRi Q15542. Positions 195-343, 436-798.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112740. 29 interactions.
DIPi DIP-28150N.
IntActi Q15542. 7 interactions.
MINTi MINT-2807293.
STRINGi 9606.ENSP00000358854.

PTM databases

PhosphoSitei Q15542.

Polymorphism databases

DMDMi 78103206.

Proteomic databases

MaxQBi Q15542.
PaxDbi Q15542.
PRIDEi Q15542.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000351396 ; ENSP00000311024 ; ENSG00000148835 . [Q15542-2 ]
ENST00000369839 ; ENSP00000358854 ; ENSG00000148835 . [Q15542-1 ]
GeneIDi 6877.
KEGGi hsa:6877.
UCSCi uc001kwv.3. human. [Q15542-1 ]
uc010qqq.2. human. [Q15542-2 ]

Organism-specific databases

CTDi 6877.
GeneCardsi GC10P105117.
HGNCi HGNC:11539. TAF5.
HPAi HPA006195.
HPA006474.
MIMi 601787. gene.
neXtProti NX_Q15542.
PharmGKBi PA36314.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG2319.
HOVERGENi HBG050226.
InParanoidi Q15542.
KOi K03130.
OMAi RFRIEGR.
OrthoDBi EOG77126F.
PhylomeDBi Q15542.
TreeFami TF300669.

Enzyme and pathway databases

Reactomei REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
REACT_1851. RNA Polymerase II Transcription Initiation.
REACT_2089. RNA Polymerase II Promoter Escape.
REACT_22107. RNA Polymerase II Pre-transcription Events.
REACT_6233. Transcription of the HIV genome.
REACT_6253. RNA Polymerase II HIV Promoter Escape.
REACT_6332. HIV Transcription Initiation.
REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.
SignaLinki Q15542.

Miscellaneous databases

EvolutionaryTracei Q15542.
GeneWikii TAF5.
GenomeRNAii 6877.
NextBioi 26855.
PROi Q15542.
SOURCEi Search...

Gene expression databases

Bgeei Q15542.
CleanExi HS_TAF5.
Genevestigatori Q15542.

Family and domain databases

Gene3Di 2.130.10.10. 1 hit.
InterProi IPR020472. G-protein_beta_WD-40_rep.
IPR006594. LisH_dimerisation.
IPR007582. TFIID-su_WD40-assoc_reg.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF04494. TFIID_90kDa. 1 hit.
PF00400. WD40. 6 hits.
[Graphical view ]
PRINTSi PR00320. GPROTEINBRPT.
SMARTi SM00667. LisH. 1 hit.
SM00320. WD40. 6 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 2 hits.
PROSITEi PS50896. LISH. 1 hit.
PS00678. WD_REPEATS_1. 3 hits.
PS50082. WD_REPEATS_2. 6 hits.
PS50294. WD_REPEATS_REGION. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Distinct domains of hTAFII100 are required for functional interaction with transcription factor TFIIF beta (RAP30) and incorporation into the TFIID complex."
    Dubrovskaya V., Lavigne A.-C., Davidson I., Acker J., Staub A., Tora L.
    EMBO J. 15:3702-3712(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT ALA-130.
    Tissue: Cervix carcinoma.
  2. "Molecular cloning and analysis of two subunits of the human TFIID complex: hTAFII130 and hTAFII100."
    Tanese N., Saluja D., Vassallo M.F., Chen J.-L., Admon A.
    Proc. Natl. Acad. Sci. U.S.A. 93:13611-13616(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), PROTEIN SEQUENCE OF 109-117; 119-142; 151-174; 372-388; 611-621; 635-649 AND 737-742, ALTERNATIVE SPLICING.
    Tissue: Cervix carcinoma.
  3. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG), VARIANT ALA-130.
    Tissue: Cervix carcinoma.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
  5. Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG), VARIANT ALA-130.
    Tissue: Brain.
  6. "The DNA sequence and comparative analysis of human chromosome 10."
    Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J.
    , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.
    Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS LONG AND SHORT), VARIANT ALA-130.
    Tissue: Prostate and Testis.
  9. "TAF-like function of SV40 large T antigen."
    Damania B., Alwine J.C.
    Genes Dev. 10:1369-1381(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SV40 LARGE T ANTIGEN.
  10. "Identification of TATA-binding protein-free TAFII-containing complex subunits suggests a role in nucleosome acetylation and signal transduction."
    Brand M., Yamamoto K., Staub A., Tora L.
    J. Biol. Chem. 274:18285-18289(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TFTC-HAT COMPLEX WITH TAF5L; TAF6L; TADA3L; SUPT3H; TAF2; TAF4; TRRAP; GCN5L2 AND TAF10.
  11. "Novel subunits of the TATA binding protein free TAFII-containing transcription complex identified by matrix-assisted laser desorption/ionization-time of flight mass spectrometry following one-dimensional gel electrophoresis."
    Cavusoglu N., Brand M., Tora L., van Dorsselaer A.
    Proteomics 3:217-223(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN THE TFTC-HAT COMPLEX, IDENTIFICATION BY MASS SPECTROMETRY.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Structural analysis and dimerization potential of the human TAF5 subunit of TFIID."
    Bhattacharya S., Takada S., Jacobson R.H.
    Proc. Natl. Acad. Sci. U.S.A. 104:1189-1194(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS) OF 188-343, SUBUNIT.

Entry informationi

Entry nameiTAF5_HUMAN
AccessioniPrimary (citable) accession number: Q15542
Secondary accession number(s): A8K5B4
, B2RMR0, B7ZKJ6, Q53EM4, Q5SYD5, Q86UZ7, Q9Y4K5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 10, 2005
Last modified: September 3, 2014
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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