Reviewed, UniProtKB/Swiss-Prot Q15532 (SSXT_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein SSXT
Alternative name(s):
    Synovial sarcoma, translocated to X chromosome
    Protein SYT

Gene names

Name:	SS18
Synonyms:	SSXT, SYT

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	418 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.
Involvement in disease	A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).
Sequence similarities	Belongs to the SS18 family.

Ontologies

Keywords
Coding sequence diversity	Alternative splicing Chromosomal rearrangement
Disease	Proto-oncogene
Domain	Repeat
Gene Ontology (GO)
Cellular component	nucleus Traceable author statement. Source: ProtInc
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15532-1)

Also known as: SYTins;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15532-2)

The sequence of this isoform differs from the canonical sequence as follows:
     295-325: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 418	418	Protein SSXT		PRO_0000181823
Regions
	Repeat	344 – 356	13	1
	Repeat	357 – 369	13	2
	Region	344 – 369	26	2 X 13 AA imperfect tandem repeats
	Motif	50 – 53	4	SH2-binding Potential
	Motif	374 – 377	4	SH2-binding Potential
	Motif	392 – 401	10	SH3-binding Potential
	Motif	413 – 416	4	SH2-binding Potential
	Compositional bias	95 – 99	5	Poly-Pro
	Compositional bias	175 – 418	244	Gln-rich
Sites
	Site	366 – 367	2	Breakpoint for translocation to form the SSXT-SSX1 fusion protein (rare)
	Site	410 – 411	2	Breakpoint for translocation to form the SSXT-SSX1 or SSXT-SSX2 fusion proteins
Natural variations
	Alternative sequence	295 – 325	31	Missing in isoform 2.		VSP_006258

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 (SYTins) [UniParc]. Last modified January 31, 2002. Version 3. Checksum: 7E089D557538252F	FASTA	418	45,929
	10 20 30 40 50 60 MSVAFAAPRQ RGKGEITPAA IQKMLDDNNH LIQCIMDSQN KGKTSECSQY QQMLHTNLVY 70 80 90 100 110 120 LATIADSNQN MQSLLPAPPT QNMPMGPGGM NQSGPPPPPR SHNMPSDGMV GGGPPAPHMQ 130 140 150 160 170 180 NQMNGQMPGP NHMPMQGPGP NQLNMTNSSM NMPSSSHGSM GGYNHSVPSS QSMPVQNQMT 190 200 210 220 230 240 MSQGQPMGNY GPRPNMSMQP NQGPMMHQQP PSQQYNMPQG GGQHYQGQQP PMGMMGQVNQ 250 260 270 280 290 300 GNHMMGQRQI PPYRPPQQGP PQQYSGQEDY YGDQYSHGGQ GPPEGMNQQY YPDGHNDYGY 310 320 330 340 350 360 QQPSYPEQGY DRPYEDSSQH YYEGGNSQYG QQQDAYQGPP PQQGYPPQQQ QYPGQQGYPG 370 380 390 400 410 QQQGYGPSQG GPGPQYPNYP QGQGQQYGGY RPTQPGPPQP PQQRPYGYDQ GQYGNYQQ
	Isoform 2. Checksum: A1D64C2C588C532A	FASTA	387	42,216
	10 20 30 40 50 60 MSVAFAAPRQ RGKGEITPAA IQKMLDDNNH LIQCIMDSQN KGKTSECSQY QQMLHTNLVY 70 80 90 100 110 120 LATIADSNQN MQSLLPAPPT QNMPMGPGGM NQSGPPPPPR SHNMPSDGMV GGGPPAPHMQ 130 140 150 160 170 180 NQMNGQMPGP NHMPMQGPGP NQLNMTNSSM NMPSSSHGSM GGYNHSVPSS QSMPVQNQMT 190 200 210 220 230 240 MSQGQPMGNY GPRPNMSMQP NQGPMMHQQP PSQQYNMPQG GGQHYQGQQP PMGMMGQVNQ 250 260 270 280 290 300 GNHMMGQRQI PPYRPPQQGP PQQYSGQEDY YGDQYSHGGQ GPPEGMNQQY YPDGNSQYGQ 310 320 330 340 350 360 QQDAYQGPPP QQGYPPQQQQ YPGQQGYPGQ QQGYGPSQGG PGPQYPNYPQ GQGQQYGGYR 370 380 PTQPGPPQPP QQRPYGYDQG QYGNYQQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma." Clark J., Rocques P.J., Crew A.J., Gill S., Shipley J., Chan A.M.-L., Gusterson B.A., Cooper C.S. Nat. Genet. 7:502-508(1994) [PubMed: 7951320] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SSXT-SSX2 FUSION PROTEIN. Tissue: Synovial sarcoma.
[2]	"Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression." Brodin B., Haslam K., Yang K., Bartolazzi A., Xie Y., Starborg M., Lundeberg J., Larsson O. Gene 268:173-182(2001) [PubMed: 11368913] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[4]	"Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript." Fligman I., Lonardo F., Jhanwar S.C., Gerald W.L., Woodruff J., Ladanyi M. Am. J. Pathol. 147:1592-1599(1995) [PubMed: 7495284] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 405-410 (SSXT-SSX2 FUSION PROTEIN).
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	X79201 mRNA. Translation: CAA55792.1. Different initiation. X79200 mRNA. No translation available. AF343880 mRNA. Translation: AAK21314.1. Different initiation. BC096223 mRNA. Translation: AAH96223.1. S79894 mRNA. Translation: AAB35674.1. Different termination.
IPI	IPI00018069. IPI00452919.
PIR	S46269.
RefSeq	NP_001007560.1. NP_005628.2.
UniGene	Hs.404263
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q15532.
Proteomic databases
PRIDE	Q15532.
Genome annotation databases
Ensembl	ENSG00000141380. Homo sapiens. [Contig view]
GeneID	6760.
KEGG	hsa:6760.
Organism-specific databases
GeneCards	GC18M021850.
H-InvDB	HIX0039710.
HGNC	HGNC:11340. SS18.
MIM	600192. gene.
Orphanet	3273. Synovialosarcoma.
PharmGKB	PA36164.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q15532.
HOVERGEN	Q15532.
OMA	Q15532. VNQGNHM.
Gene expression databases
ArrayExpress	Q15532.
Bgee	Q15532.
CleanEx	HS_SS18.
GermOnline	ENSG00000141380. Homo sapiens.
Family and domain databases
InterPro	IPR007726. SSXT. [Graphical view]
PANTHER	PTHR23107. SSXT. 1 hit.
Pfam	PF05030. SSXT. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	26388.
SOURCE	Search...

Entry information

Entry name

SSXT_HUMAN

Accession

Primary (citable) accession number: Q15532
Secondary accession number(s): Q16404, Q4VAX1, Q9BXC6

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	January 31, 2002
Last modified:	May 26, 2009
This is version 74 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)