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Q15532

- SSXT_HUMAN

UniProt

Q15532 - SSXT_HUMAN

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Protein
Protein SSXT
Gene
SS18, SSXT, SYT
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei366 – 3672Breakpoint for translocation to form the SSXT-SSX1 fusion protein (rare)
Sitei410 – 4112Breakpoint for translocation to form the SSXT-SSX1 or SSXT-SSX2 fusion proteins

GO - Molecular functioni

  1. ligand-dependent nuclear receptor transcription coactivator activity Source: UniProtKB
  2. protein binding Source: UniProtKB

GO - Biological processi

  1. cell morphogenesis Source: Ensembl
  2. ephrin receptor signaling pathway Source: Ensembl
  3. microtubule cytoskeleton organization Source: Ensembl
  4. positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  5. response to drug Source: Ensembl
  6. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein SSXT
Alternative name(s):
Protein SYT
Synovial sarcoma translocated to X chromosome protein
Gene namesi
Name:SS18
Synonyms:SSXT, SYT
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 18

Organism-specific databases

HGNCiHGNC:11340. SS18.

Subcellular locationi

Nucleus Inferred

GO - Cellular componenti

  1. cytoplasmic microtubule Source: Ensembl
  2. nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving SS18 may be a cause of synovial sarcoma. Translocation t(X;18)(p11.2;q11.2). The translocation is specifically found in more than 80% of synovial sarcoma. The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity. Heterogeneity in the position of the breakpoint can occur (low frequency).

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

Orphaneti3273. Synovial sarcoma.
PharmGKBiPA36164.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 418417Protein SSXT
PRO_0000181823Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ15532.
PaxDbiQ15532.
PRIDEiQ15532.

PTM databases

PhosphoSiteiQ15532.

Expressioni

Tissue specificityi

Fairly ubiquitously expressed. Expressed in synovial sarcomas and in other human cell lines. The fusion genes SSXT-SSX1 and SSXT-SSX2 are expressed only in synovial sarcomas.

Gene expression databases

ArrayExpressiQ15532.
BgeeiQ15532.
CleanExiHS_SS18.
GenevestigatoriQ15532.

Organism-specific databases

HPAiHPA055741.
HPA059539.

Interactioni

Subunit structurei

Interacts with MLLT10. Isoform 1 interacts with RBM14 isoform 1. Isoform 2 interacts with RBM14 isoform 1.2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
ATF2P153362EBI-2560599,EBI-1170906

Protein-protein interaction databases

BioGridi112638. 21 interactions.
IntActiQ15532. 16 interactions.
STRINGi9606.ENSP00000269138.

Structurei

3D structure databases

ProteinModelPortaliQ15532.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati344 – 356131
Add
BLAST
Repeati357 – 369132
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni2 – 186185Transcriptional activation
Add
BLAST
Regioni344 – 369262 X 13 AA imperfect tandem repeats
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi50 – 534SH2-binding Reviewed prediction
Motifi374 – 3774SH2-binding Reviewed prediction
Motifi392 – 40110SH3-binding Reviewed prediction
Motifi413 – 4164SH2-binding Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi95 – 995Poly-Pro
Compositional biasi175 – 418244Gln-rich
Add
BLAST

Sequence similaritiesi

Belongs to the SS18 family.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG274014.
HOVERGENiHBG003892.
InParanoidiQ15532.
KOiK15623.
OMAiNQLIQCI.
OrthoDBiEOG7B31R1.
PhylomeDBiQ15532.
TreeFamiTF330999.

Family and domain databases

InterProiIPR007726. SS18_fam.
[Graphical view]
PANTHERiPTHR23107. PTHR23107. 1 hit.
PfamiPF05030. SSXT. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15532-1) [UniParc]FASTAAdd to Basket

Also known as: SYTins, SYT-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MSVAFAAPRQ RGKGEITPAA IQKMLDDNNH LIQCIMDSQN KGKTSECSQY    50
QQMLHTNLVY LATIADSNQN MQSLLPAPPT QNMPMGPGGM NQSGPPPPPR 100
SHNMPSDGMV GGGPPAPHMQ NQMNGQMPGP NHMPMQGPGP NQLNMTNSSM 150
NMPSSSHGSM GGYNHSVPSS QSMPVQNQMT MSQGQPMGNY GPRPNMSMQP 200
NQGPMMHQQP PSQQYNMPQG GGQHYQGQQP PMGMMGQVNQ GNHMMGQRQI 250
PPYRPPQQGP PQQYSGQEDY YGDQYSHGGQ GPPEGMNQQY YPDGHNDYGY 300
QQPSYPEQGY DRPYEDSSQH YYEGGNSQYG QQQDAYQGPP PQQGYPPQQQ 350
QYPGQQGYPG QQQGYGPSQG GPGPQYPNYP QGQGQQYGGY RPTQPGPPQP 400
PQQRPYGYDQ GQYGNYQQ 418
Length:418
Mass (Da):45,929
Last modified:January 31, 2002 - v3
Checksum:i7E089D557538252F
GO
Isoform 2 (identifier: Q15532-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     295-325: Missing.

Show »
Length:387
Mass (Da):42,216
Checksum:iA1D64C2C588C532A
GO

Sequence cautioni

The sequence AAK21314.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAA55792.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei295 – 32531Missing in isoform 2.
VSP_006258Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79201 mRNA. Translation: CAA55792.1. Different initiation.
X79200 mRNA. No translation available.
AF343880 mRNA. Translation: AAK21314.1. Different initiation.
EF445031 Genomic DNA. Translation: ACA06073.1.
CH471088 Genomic DNA. Translation: EAX01210.1.
BC096223 mRNA. Translation: AAH96223.1.
S79894 mRNA. Translation: AAB35674.1. Different termination.
CCDSiCCDS32807.1. [Q15532-1]
CCDS54183.1. [Q15532-2]
PIRiS46269.
RefSeqiNP_001007560.1. NM_001007559.1. [Q15532-1]
NP_005628.2. NM_005637.2. [Q15532-2]
UniGeneiHs.129261.

Genome annotation databases

EnsembliENST00000269137; ENSP00000269137; ENSG00000141380. [Q15532-2]
ENST00000415083; ENSP00000414516; ENSG00000141380. [Q15532-1]
GeneIDi6760.
KEGGihsa:6760.
UCSCiuc002kvm.3. human. [Q15532-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X79201 mRNA. Translation: CAA55792.1 . Different initiation.
X79200 mRNA. No translation available.
AF343880 mRNA. Translation: AAK21314.1 . Different initiation.
EF445031 Genomic DNA. Translation: ACA06073.1 .
CH471088 Genomic DNA. Translation: EAX01210.1 .
BC096223 mRNA. Translation: AAH96223.1 .
S79894 mRNA. Translation: AAB35674.1 . Different termination.
CCDSi CCDS32807.1. [Q15532-1 ]
CCDS54183.1. [Q15532-2 ]
PIRi S46269.
RefSeqi NP_001007560.1. NM_001007559.1. [Q15532-1 ]
NP_005628.2. NM_005637.2. [Q15532-2 ]
UniGenei Hs.129261.

3D structure databases

ProteinModelPortali Q15532.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112638. 21 interactions.
IntActi Q15532. 16 interactions.
STRINGi 9606.ENSP00000269138.

PTM databases

PhosphoSitei Q15532.

Proteomic databases

MaxQBi Q15532.
PaxDbi Q15532.
PRIDEi Q15532.

Protocols and materials databases

DNASUi 6760.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000269137 ; ENSP00000269137 ; ENSG00000141380 . [Q15532-2 ]
ENST00000415083 ; ENSP00000414516 ; ENSG00000141380 . [Q15532-1 ]
GeneIDi 6760.
KEGGi hsa:6760.
UCSCi uc002kvm.3. human. [Q15532-1 ]

Organism-specific databases

CTDi 6760.
GeneCardsi GC18M023596.
HGNCi HGNC:11340. SS18.
HPAi HPA055741.
HPA059539.
MIMi 600192. gene.
neXtProti NX_Q15532.
Orphaneti 3273. Synovial sarcoma.
PharmGKBi PA36164.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG274014.
HOVERGENi HBG003892.
InParanoidi Q15532.
KOi K15623.
OMAi NQLIQCI.
OrthoDBi EOG7B31R1.
PhylomeDBi Q15532.
TreeFami TF330999.

Miscellaneous databases

ChiTaRSi SS18. human.
GeneWikii SS18.
GenomeRNAii 6760.
NextBioi 26388.
PROi Q15532.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15532.
Bgeei Q15532.
CleanExi HS_SS18.
Genevestigatori Q15532.

Family and domain databases

InterProi IPR007726. SS18_fam.
[Graphical view ]
PANTHERi PTHR23107. PTHR23107. 1 hit.
Pfami PF05030. SSXT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Identification of novel genes, SYT and SSX, involved in the t(X;18)(p11.2;q11.2) translocation found in human synovial sarcoma."
    Clark J., Rocques P.J., Crew A.J., Gill S., Shipley J., Chan A.M.-L., Gusterson B.A., Cooper C.S.
    Nat. Genet. 7:502-508(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), SSXT-SSX2 FUSION PROTEIN.
    Tissue: Synovial sarcoma.
  2. "Cloning and characterization of spliced fusion transcript variants of synovial sarcoma: SYT/SSX4, SYT/SSX4v, and SYT/SSX2v. Possible regulatory role of the fusion gene product in wild type SYT expression."
    Brodin B., Haslam K., Yang K., Bartolazzi A., Xie Y., Starborg M., Lundeberg J., Larsson O.
    Gene 268:173-182(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  3. NHLBI resequencing and genotyping service (RS&G)
    Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "Molecular diagnosis of synovial sarcoma and characterization of a variant SYT-SSX2 fusion transcript."
    Fligman I., Lonardo F., Jhanwar S.C., Gerald W.L., Woodruff J., Ladanyi M.
    Am. J. Pathol. 147:1592-1599(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 405-410 (SSXT-SSX2 FUSION PROTEIN).
  7. "The synovial sarcoma associated protein SYT interacts with the acute leukemia associated protein AF10."
    de Bruijn D.R., dos Santos N.R., Thijssen J., Balemans M., Debernardi S., Linder B., Young B.D., Geurts van Kessel A.
    Oncogene 20:3281-3289(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MLLT10.
  8. "Synovial sarcoma translocation (SYT) encodes a nuclear receptor coactivator."
    Iwasaki T., Koibuchi N., Chin W.W.
    Endocrinology 146:3892-3899(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, ALTERNATIVE SPLICING, INTERACTION WITH RBM14.
  9. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSSXT_HUMAN
AccessioniPrimary (citable) accession number: Q15532
Secondary accession number(s): B0YJ95
, Q16404, Q4VAX1, Q9BXC6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: January 31, 2002
Last modified: July 9, 2014
This is version 121 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 18
    Human chromosome 18: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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