SURF2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Surfeit locus protein 2 Short name: Surf-2
Gene namesⁱ	Name:SURF2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000148291.9
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11475 SURF2
MIMⁱ	185630 gene
neXtProtⁱ	NX_Q15527

Subcellular locationⁱ

GO - Cellular component

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA36260

PharmGKBⁱ

PA36260

Polymorphism and mutation databases

DMDMⁱ	317373505

DMDMⁱ

317373505

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072319	1 – 256	Surfeit locus protein 2Add BLAST		256

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	190	PhosphothreonineCombined sources		1
Modified residueⁱ	195	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q15527
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15527
PaxDbⁱ	Q15527
PeptideAtlas More...PeptideAtlasⁱ	Q15527
PRIDEⁱ	Q15527
ProteomicsDBⁱ	60618

PTM databases

iPTMnetⁱ	Q15527
PhosphoSitePlusⁱ	Q15527

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148291
CleanExⁱ	HS_SURF2
Genevisibleⁱ	Q15527 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044340 HPA052213

HPAⁱ

HPA044340
HPA052213

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	112702, 58 interactors
IntActⁱ	Q15527, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q15527
STRINGⁱ	9606.ENSP00000361032

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15527
SMRⁱ	Q15527
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SURF2 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IK6I Eukaryota ENOG4111NE1 LUCA
HOGENOMⁱ	HOG000136540
HOVERGENⁱ	HBG054804
InParanoidⁱ	Q15527
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L5E
PhylomeDBⁱ	Q15527
TreeFamⁱ	TF329107

Family and domain databases

InterProⁱ	View protein in InterPro IPR008833 Surf2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05477 SURF2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Q15527-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK 
        60         70         80         90        100
KYQRLVRASP AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH 
       110        120        130        140        150
TQGRRYQRAL CKYEECQKQG VEYVPACLVH RRRRREDQMD GDGPRPREAF 
       160        170        180        190        200
WEPTSSDEGG AASDDSMTDL YPPELFTRKD LGSTEDGDGT DDFLTDKEDE 
       210        220        230        240        250
KAKPPREKAT DESRRETTVY RGLVQKRGKK QLGSLKKKFK SHHRKPKSFS 

SCKQPG

Length:256

Mass (Da):29,648

Last modified:January 11, 2011 - v3

Checksum:ⁱ5CA1BDEB73CB5127

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	24	A → T in CAA84477 (PubMed:7702754).Curated	1
Sequence conflictⁱ	37	P → T in CAA84477 (PubMed:7702754).Curated	1
Sequence conflictⁱ	142 – 143	DG → EA in CAA84477 (PubMed:7702754).Curated	2
Sequence conflictⁱ	160	G → A in CAA84477 (PubMed:7702754).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_014785	213	S → G2 PublicationsCorresponds to variant dbSNP:rs12763Ensembl.		1
Natural variantⁱVAR_057001	221	R → Q1 PublicationCorresponds to variant dbSNP:rs7863933Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z35094 mRNA Translation: CAA84477.1 CR456753 mRNA Translation: CAG33034.1 AL158826 Genomic DNA Translation: CAI12838.1 BC014411 mRNA Translation: AAH14411.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6967.1
PIRⁱ	S57747
NCBI Reference Sequences More...RefSeqⁱ	NP_001265857.1, NM_001278928.1 NP_059973.4, NM_017503.4
UniGeneⁱ	Hs.159448

Genome annotation databases

Ensemblⁱ	ENST00000371964; ENSP00000361032; ENSG00000148291
GeneIDⁱ	6835
KEGGⁱ	hsa:6835
UCSC genome browser More...UCSCⁱ	uc004cdi.4 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Protein	Similar proteins		Species	Score	Length
Q15527	Surfeit 2, isoform CRA_a		HUMAN		78
Surfeit 2		PANPA		258
SURF2 isoform 1		PANTR		257
Surfeit 2		GORGO		257
Surfeit 2		MACMU		256
+22

Protein	Similar proteins		Species	Score	Length
Q15527	Surfeit 2, isoform CRA_a		HUMAN		78
Surfeit 2		PANPA		258
SURF2 isoform 1		PANTR		257
Surfeit 2		GORGO		257
SURF2 isoform 1		PONAB		256
+77

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z35094 mRNA Translation: CAA84477.1 CR456753 mRNA Translation: CAG33034.1 AL158826 Genomic DNA Translation: CAI12838.1 BC014411 mRNA Translation: AAH14411.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6967.1
PIRⁱ	S57747
NCBI Reference Sequences More...RefSeqⁱ	NP_001265857.1, NM_001278928.1 NP_059973.4, NM_017503.4
UniGeneⁱ	Hs.159448

3D structure databases

ProteinModelPortalⁱ	Q15527
SMRⁱ	Q15527
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112702, 58 interactors
IntActⁱ	Q15527, 7 interactors
Molecular INTeraction database More...MINTⁱ	Q15527
STRINGⁱ	9606.ENSP00000361032

PTM databases

iPTMnetⁱ	Q15527
PhosphoSitePlusⁱ	Q15527

Polymorphism and mutation databases

DMDMⁱ	317373505

DMDMⁱ

317373505

Proteomic databases

EPDⁱ	Q15527
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15527
PaxDbⁱ	Q15527
PeptideAtlas More...PeptideAtlasⁱ	Q15527
PRIDEⁱ	Q15527
ProteomicsDBⁱ	60618

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6835
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371964; ENSP00000361032; ENSG00000148291
GeneIDⁱ	6835
KEGGⁱ	hsa:6835
UCSC genome browser More...UCSCⁱ	uc004cdi.4 human

Organism-specific databases

CTDⁱ	6835
EuPathDBⁱ	HostDB:ENSG00000148291.9
GeneCardsⁱ	SURF2
H-InvDBⁱ	HIX0008504
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11475 SURF2
Human Protein Atlas More...HPAⁱ	HPA044340 HPA052213
MIMⁱ	185630 gene
neXtProtⁱ	NX_Q15527
PharmGKBⁱ	PA36260
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IK6I Eukaryota ENOG4111NE1 LUCA
HOGENOMⁱ	HOG000136540
HOVERGENⁱ	HBG054804
InParanoidⁱ	Q15527
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L5E
PhylomeDBⁱ	Q15527
TreeFamⁱ	TF329107

Miscellaneous databases

ChiTaRSⁱ	SURF2 human
GenomeRNAiⁱ	6835
Protein Ontology More...PROⁱ	PR:Q15527
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148291
CleanExⁱ	HS_SURF2
Genevisibleⁱ	Q15527 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR008833 Surf2
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05477 SURF2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SURF2_HUMAN
Accessionⁱ	Q15527Primary (citable) accession number: Q15527 Secondary accession number(s): Q6IBP9, Q96CD1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 11, 2011
	Last modified:	June 20, 2018
	This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15527 (SURF2_HUMAN)

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Surfeit locus protein 2

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Plasma Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

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Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ