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Protein

Surfeit locus protein 2

Gene

SURF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148291-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 2
Short name:
Surf-2
Gene namesi
Name:SURF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:11475. SURF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36260.

Polymorphism and mutation databases

DMDMi317373505.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723191 – 256Surfeit locus protein 2Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei190PhosphothreonineCombined sources1
Modified residuei195PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15527.
MaxQBiQ15527.
PaxDbiQ15527.
PeptideAtlasiQ15527.
PRIDEiQ15527.

PTM databases

iPTMnetiQ15527.
PhosphoSitePlusiQ15527.

Expressioni

Gene expression databases

BgeeiENSG00000148291.
CleanExiHS_SURF2.
GenevisibleiQ15527. HS.

Organism-specific databases

HPAiHPA044340.
HPA052213.

Interactioni

Protein-protein interaction databases

BioGridi112702. 56 interactors.
IntActiQ15527. 7 interactors.
MINTiMINT-1371424.
STRINGi9606.ENSP00000361032.

Structurei

3D structure databases

ProteinModelPortaliQ15527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SURF2 family.Curated

Phylogenomic databases

eggNOGiENOG410IK6I. Eukaryota.
ENOG4111NE1. LUCA.
HOGENOMiHOG000136540.
HOVERGENiHBG054804.
InParanoidiQ15527.
OrthoDBiEOG091G0L5E.
PhylomeDBiQ15527.
TreeFamiTF329107.

Family and domain databases

InterProiIPR008833. Surf2.
[Graphical view]
PfamiPF05477. SURF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK
60 70 80 90 100
KYQRLVRASP AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH
110 120 130 140 150
TQGRRYQRAL CKYEECQKQG VEYVPACLVH RRRRREDQMD GDGPRPREAF
160 170 180 190 200
WEPTSSDEGG AASDDSMTDL YPPELFTRKD LGSTEDGDGT DDFLTDKEDE
210 220 230 240 250
KAKPPREKAT DESRRETTVY RGLVQKRGKK QLGSLKKKFK SHHRKPKSFS

SCKQPG
Length:256
Mass (Da):29,648
Last modified:January 11, 2011 - v3
Checksum:i5CA1BDEB73CB5127
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24A → T in CAA84477 (PubMed:7702754).Curated1
Sequence conflicti37P → T in CAA84477 (PubMed:7702754).Curated1
Sequence conflicti142 – 143DG → EA in CAA84477 (PubMed:7702754).Curated2
Sequence conflicti160G → A in CAA84477 (PubMed:7702754).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014785213S → G.2 PublicationsCorresponds to variant rs12763dbSNPEnsembl.1
Natural variantiVAR_057001221R → Q.1 PublicationCorresponds to variant rs7863933dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35094 mRNA. Translation: CAA84477.1.
CR456753 mRNA. Translation: CAG33034.1.
AL158826 Genomic DNA. Translation: CAI12838.1.
BC014411 mRNA. Translation: AAH14411.1.
CCDSiCCDS6967.1.
PIRiS57747.
RefSeqiNP_001265857.1. NM_001278928.1.
NP_059973.4. NM_017503.4.
UniGeneiHs.159448.

Genome annotation databases

EnsembliENST00000371964; ENSP00000361032; ENSG00000148291.
GeneIDi6835.
KEGGihsa:6835.
UCSCiuc004cdi.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35094 mRNA. Translation: CAA84477.1.
CR456753 mRNA. Translation: CAG33034.1.
AL158826 Genomic DNA. Translation: CAI12838.1.
BC014411 mRNA. Translation: AAH14411.1.
CCDSiCCDS6967.1.
PIRiS57747.
RefSeqiNP_001265857.1. NM_001278928.1.
NP_059973.4. NM_017503.4.
UniGeneiHs.159448.

3D structure databases

ProteinModelPortaliQ15527.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112702. 56 interactors.
IntActiQ15527. 7 interactors.
MINTiMINT-1371424.
STRINGi9606.ENSP00000361032.

PTM databases

iPTMnetiQ15527.
PhosphoSitePlusiQ15527.

Polymorphism and mutation databases

DMDMi317373505.

Proteomic databases

EPDiQ15527.
MaxQBiQ15527.
PaxDbiQ15527.
PeptideAtlasiQ15527.
PRIDEiQ15527.

Protocols and materials databases

DNASUi6835.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000371964; ENSP00000361032; ENSG00000148291.
GeneIDi6835.
KEGGihsa:6835.
UCSCiuc004cdi.4. human.

Organism-specific databases

CTDi6835.
GeneCardsiSURF2.
H-InvDBHIX0008504.
HGNCiHGNC:11475. SURF2.
HPAiHPA044340.
HPA052213.
MIMi185630. gene.
neXtProtiNX_Q15527.
PharmGKBiPA36260.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK6I. Eukaryota.
ENOG4111NE1. LUCA.
HOGENOMiHOG000136540.
HOVERGENiHBG054804.
InParanoidiQ15527.
OrthoDBiEOG091G0L5E.
PhylomeDBiQ15527.
TreeFamiTF329107.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000148291-MONOMER.

Miscellaneous databases

ChiTaRSiSURF2. human.
GenomeRNAii6835.
PROiQ15527.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148291.
CleanExiHS_SURF2.
GenevisibleiQ15527. HS.

Family and domain databases

InterProiIPR008833. Surf2.
[Graphical view]
PfamiPF05477. SURF2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSURF2_HUMAN
AccessioniPrimary (citable) accession number: Q15527
Secondary accession number(s): Q6IBP9, Q96CD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2011
Last modified: November 2, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.