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Q15527 (SURF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Surfeit locus protein 2

Short name=Surf-2
Gene names
Name:SURF2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the SURF2 family.

Ontologies

Keywords
   Coding sequence diversityPolymorphism
   PTMPhosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentnucleolus

Inferred from direct assay. Source: HPA

nucleus

Inferred from direct assay. Source: HPA

plasma membrane

Inferred from direct assay. Source: HPA

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256Surfeit locus protein 2
PRO_0000072319

Amino acid modifications

Modified residue1901Phosphothreonine Ref.5 Ref.7 Ref.8 Ref.9
Modified residue1951Phosphothreonine Ref.5 Ref.7 Ref.9

Natural variations

Natural variant2131S → G. Ref.1 Ref.2
Corresponds to variant rs12763 [ dbSNP | Ensembl ].
VAR_014785
Natural variant2211R → Q. Ref.1
Corresponds to variant rs7863933 [ dbSNP | Ensembl ].
VAR_057001

Experimental info

Sequence conflict241A → T in CAA84477. Ref.1
Sequence conflict371P → T in CAA84477. Ref.1
Sequence conflict142 – 1432DG → EA in CAA84477. Ref.1
Sequence conflict1601G → A in CAA84477. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q15527 [UniParc].

Last modified January 11, 2011. Version 3.
Checksum: 5CA1BDEB73CB5127

FASTA25629,648
        10         20         30         40         50         60 
MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK KYQRLVRASP 

        70         80         90        100        110        120 
AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH TQGRRYQRAL CKYEECQKQG 

       130        140        150        160        170        180 
VEYVPACLVH RRRRREDQMD GDGPRPREAF WEPTSSDEGG AASDDSMTDL YPPELFTRKD 

       190        200        210        220        230        240 
LGSTEDGDGT DDFLTDKEDE KAKPPREKAT DESRRETTVY RGLVQKRGKK QLGSLKKKFK 

       250 
SHHRKPKSFS SCKQPG 

« Hide

References

« Hide 'large scale' references
[1]"The Surf-1 and Surf-2 genes and their essential bidirectional promoter elements are conserved between mouse and human."
Lennard A., Gaston K., Fried M.
DNA Cell Biol. 13:1117-1126(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-213 AND GLN-221.
[2]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-213.
[3]"DNA sequence and analysis of human chromosome 9."
Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. expand/collapse author list , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Lung.
[5]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[6]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[8]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[9]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Z35094 mRNA. Translation: CAA84477.1.
CR456753 mRNA. Translation: CAG33034.1.
AL158826 Genomic DNA. Translation: CAI12838.1.
BC014411 mRNA. Translation: AAH14411.1.
PIRS57747.
RefSeqNP_001265857.1. NM_001278928.1.
NP_059973.4. NM_017503.4.
UniGeneHs.159448.

3D structure databases

ProteinModelPortalQ15527.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112702. 28 interactions.
IntActQ15527. 7 interactions.
MINTMINT-1371424.
STRING9606.ENSP00000361032.

PTM databases

PhosphoSiteQ15527.

Polymorphism databases

DMDM317373505.

Proteomic databases

PaxDbQ15527.
PRIDEQ15527.

Protocols and materials databases

DNASU6835.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000371964; ENSP00000361032; ENSG00000148291.
ENST00000566819; ENSP00000457376; ENSG00000261361.
GeneID6835.
KEGGhsa:6835.
UCSCuc004cdi.2. human.

Organism-specific databases

CTD6835.
GeneCardsGC09P136223.
H-InvDBHIX0008504.
HGNCHGNC:11475. SURF2.
HPAHPA044340.
HPA052213.
MIM185630. gene.
neXtProtNX_Q15527.
PharmGKBPA36260.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG43972.
HOGENOMHOG000136540.
HOVERGENHBG054804.
InParanoidQ15527.
OMAIARWEEC.
OrthoDBEOG7ZKSD9.
PhylomeDBQ15527.
TreeFamTF329107.

Gene expression databases

BgeeQ15527.
CleanExHS_SURF2.
GenevestigatorQ15527.

Family and domain databases

InterProIPR008833. Surf2.
[Graphical view]
PfamPF05477. SURF2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSURF2. human.
GenomeRNAi6835.
NextBio26683.
PROQ15527.
SOURCESearch...

Entry information

Entry nameSURF2_HUMAN
AccessionPrimary (citable) accession number: Q15527
Secondary accession number(s): Q6IBP9, Q96CD1
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2011
Last modified: April 16, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 9

Human chromosome 9: entries, gene names and cross-references to MIM