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Protein

Surfeit locus protein 2

Gene

SURF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 2
Short name:
Surf-2
Gene namesi
Name:SURF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000148291.9
HGNCiHGNC:11475 SURF2
MIMi185630 gene
neXtProtiNX_Q15527

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36260

Polymorphism and mutation databases

DMDMi317373505

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000723191 – 256Surfeit locus protein 2Add BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei190PhosphothreonineCombined sources1
Modified residuei195PhosphothreonineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15527
MaxQBiQ15527
PaxDbiQ15527
PeptideAtlasiQ15527
PRIDEiQ15527
ProteomicsDBi60618

PTM databases

iPTMnetiQ15527
PhosphoSitePlusiQ15527

Expressioni

Gene expression databases

BgeeiENSG00000148291
CleanExiHS_SURF2
GenevisibleiQ15527 HS

Organism-specific databases

HPAiHPA044340
HPA052213

Interactioni

Protein-protein interaction databases

BioGridi112702, 58 interactors
IntActiQ15527, 7 interactors
MINTiQ15527
STRINGi9606.ENSP00000361032

Structurei

3D structure databases

ProteinModelPortaliQ15527
SMRiQ15527
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SURF2 family.Curated

Phylogenomic databases

eggNOGiENOG410IK6I Eukaryota
ENOG4111NE1 LUCA
HOGENOMiHOG000136540
HOVERGENiHBG054804
InParanoidiQ15527
OrthoDBiEOG091G0L5E
PhylomeDBiQ15527
TreeFamiTF329107

Family and domain databases

InterProiView protein in InterPro
IPR008833 Surf2
PfamiView protein in Pfam
PF05477 SURF2, 1 hit

Sequencei

Sequence statusi: Complete.

Q15527-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK
60 70 80 90 100
KYQRLVRASP AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH
110 120 130 140 150
TQGRRYQRAL CKYEECQKQG VEYVPACLVH RRRRREDQMD GDGPRPREAF
160 170 180 190 200
WEPTSSDEGG AASDDSMTDL YPPELFTRKD LGSTEDGDGT DDFLTDKEDE
210 220 230 240 250
KAKPPREKAT DESRRETTVY RGLVQKRGKK QLGSLKKKFK SHHRKPKSFS

SCKQPG
Length:256
Mass (Da):29,648
Last modified:January 11, 2011 - v3
Checksum:i5CA1BDEB73CB5127
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti24A → T in CAA84477 (PubMed:7702754).Curated1
Sequence conflicti37P → T in CAA84477 (PubMed:7702754).Curated1
Sequence conflicti142 – 143DG → EA in CAA84477 (PubMed:7702754).Curated2
Sequence conflicti160G → A in CAA84477 (PubMed:7702754).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_014785213S → G2 PublicationsCorresponds to variant dbSNP:rs12763Ensembl.1
Natural variantiVAR_057001221R → Q1 PublicationCorresponds to variant dbSNP:rs7863933Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z35094 mRNA Translation: CAA84477.1
CR456753 mRNA Translation: CAG33034.1
AL158826 Genomic DNA Translation: CAI12838.1
BC014411 mRNA Translation: AAH14411.1
CCDSiCCDS6967.1
PIRiS57747
RefSeqiNP_001265857.1, NM_001278928.1
NP_059973.4, NM_017503.4
UniGeneiHs.159448

Genome annotation databases

EnsembliENST00000371964; ENSP00000361032; ENSG00000148291
GeneIDi6835
KEGGihsa:6835
UCSCiuc004cdi.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiSURF2_HUMAN
AccessioniPrimary (citable) accession number: Q15527
Secondary accession number(s): Q6IBP9, Q96CD1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2011
Last modified: June 20, 2018
This is version 131 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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