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Q15527

- SURF2_HUMAN

UniProt

Q15527 - SURF2_HUMAN

Protein

Surfeit locus protein 2

Gene

SURF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (11 Jan 2011)
      Previous versions | rss
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    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Surfeit locus protein 2
    Short name:
    Surf-2
    Gene namesi
    Name:SURF2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:11475. SURF2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleolus Source: HPA
    2. nucleus Source: HPA
    3. plasma membrane Source: HPA

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36260.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256Surfeit locus protein 2PRO_0000072319Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei190 – 1901Phosphothreonine4 Publications
    Modified residuei195 – 1951Phosphothreonine3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ15527.
    PaxDbiQ15527.
    PRIDEiQ15527.

    PTM databases

    PhosphoSiteiQ15527.

    Expressioni

    Gene expression databases

    BgeeiQ15527.
    CleanExiHS_SURF2.
    GenevestigatoriQ15527.

    Organism-specific databases

    HPAiHPA044340.
    HPA052213.

    Interactioni

    Protein-protein interaction databases

    BioGridi112702. 29 interactions.
    IntActiQ15527. 7 interactions.
    MINTiMINT-1371424.
    STRINGi9606.ENSP00000361032.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15527.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SURF2 family.Curated

    Phylogenomic databases

    eggNOGiNOG43972.
    HOGENOMiHOG000136540.
    HOVERGENiHBG054804.
    InParanoidiQ15527.
    OMAiHLNKLPS.
    OrthoDBiEOG7ZKSD9.
    PhylomeDBiQ15527.
    TreeFamiTF329107.

    Family and domain databases

    InterProiIPR008833. Surf2.
    [Graphical view]
    PfamiPF05477. SURF2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15527-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK    50
    KYQRLVRASP AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH 100
    TQGRRYQRAL CKYEECQKQG VEYVPACLVH RRRRREDQMD GDGPRPREAF 150
    WEPTSSDEGG AASDDSMTDL YPPELFTRKD LGSTEDGDGT DDFLTDKEDE 200
    KAKPPREKAT DESRRETTVY RGLVQKRGKK QLGSLKKKFK SHHRKPKSFS 250
    SCKQPG 256
    Length:256
    Mass (Da):29,648
    Last modified:January 11, 2011 - v3
    Checksum:i5CA1BDEB73CB5127
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241A → T in CAA84477. (PubMed:7702754)Curated
    Sequence conflicti37 – 371P → T in CAA84477. (PubMed:7702754)Curated
    Sequence conflicti142 – 1432DG → EA in CAA84477. (PubMed:7702754)Curated
    Sequence conflicti160 – 1601G → A in CAA84477. (PubMed:7702754)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti213 – 2131S → G.2 Publications
    Corresponds to variant rs12763 [ dbSNP | Ensembl ].
    VAR_014785
    Natural varianti221 – 2211R → Q.1 Publication
    Corresponds to variant rs7863933 [ dbSNP | Ensembl ].
    VAR_057001

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35094 mRNA. Translation: CAA84477.1.
    CR456753 mRNA. Translation: CAG33034.1.
    AL158826 Genomic DNA. Translation: CAI12838.1.
    BC014411 mRNA. Translation: AAH14411.1.
    CCDSiCCDS6967.1.
    PIRiS57747.
    RefSeqiNP_001265857.1. NM_001278928.1.
    NP_059973.4. NM_017503.4.
    UniGeneiHs.159448.

    Genome annotation databases

    EnsembliENST00000371964; ENSP00000361032; ENSG00000148291.
    GeneIDi6835.
    KEGGihsa:6835.
    UCSCiuc004cdi.2. human.

    Polymorphism databases

    DMDMi317373505.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35094 mRNA. Translation: CAA84477.1 .
    CR456753 mRNA. Translation: CAG33034.1 .
    AL158826 Genomic DNA. Translation: CAI12838.1 .
    BC014411 mRNA. Translation: AAH14411.1 .
    CCDSi CCDS6967.1.
    PIRi S57747.
    RefSeqi NP_001265857.1. NM_001278928.1.
    NP_059973.4. NM_017503.4.
    UniGenei Hs.159448.

    3D structure databases

    ProteinModelPortali Q15527.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112702. 29 interactions.
    IntActi Q15527. 7 interactions.
    MINTi MINT-1371424.
    STRINGi 9606.ENSP00000361032.

    PTM databases

    PhosphoSitei Q15527.

    Polymorphism databases

    DMDMi 317373505.

    Proteomic databases

    MaxQBi Q15527.
    PaxDbi Q15527.
    PRIDEi Q15527.

    Protocols and materials databases

    DNASUi 6835.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371964 ; ENSP00000361032 ; ENSG00000148291 .
    GeneIDi 6835.
    KEGGi hsa:6835.
    UCSCi uc004cdi.2. human.

    Organism-specific databases

    CTDi 6835.
    GeneCardsi GC09P136223.
    H-InvDB HIX0008504.
    HGNCi HGNC:11475. SURF2.
    HPAi HPA044340.
    HPA052213.
    MIMi 185630. gene.
    neXtProti NX_Q15527.
    PharmGKBi PA36260.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG43972.
    HOGENOMi HOG000136540.
    HOVERGENi HBG054804.
    InParanoidi Q15527.
    OMAi HLNKLPS.
    OrthoDBi EOG7ZKSD9.
    PhylomeDBi Q15527.
    TreeFami TF329107.

    Miscellaneous databases

    ChiTaRSi SURF2. human.
    GenomeRNAii 6835.
    NextBioi 26683.
    PROi Q15527.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15527.
    CleanExi HS_SURF2.
    Genevestigatori Q15527.

    Family and domain databases

    InterProi IPR008833. Surf2.
    [Graphical view ]
    Pfami PF05477. SURF2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Surf-1 and Surf-2 genes and their essential bidirectional promoter elements are conserved between mouse and human."
      Lennard A., Gaston K., Fried M.
      DNA Cell Biol. 13:1117-1126(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-213 AND GLN-221.
    2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-213.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Lung.
    5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSURF2_HUMAN
    AccessioniPrimary (citable) accession number: Q15527
    Secondary accession number(s): Q6IBP9, Q96CD1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 11, 2011
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3