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Q15527

- SURF2_HUMAN

UniProt

Q15527 - SURF2_HUMAN

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Protein

Surfeit locus protein 2

Gene

SURF2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Surfeit locus protein 2
Short name:
Surf-2
Gene namesi
Name:SURF2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:11475. SURF2.

Subcellular locationi

GO - Cellular componenti

  1. nucleolus Source: HPA
  2. nucleus Source: HPA
  3. plasma membrane Source: HPA
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36260.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 256256Surfeit locus protein 2PRO_0000072319Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei190 – 1901Phosphothreonine4 Publications
Modified residuei195 – 1951Phosphothreonine3 Publications

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15527.
PaxDbiQ15527.
PRIDEiQ15527.

PTM databases

PhosphoSiteiQ15527.

Expressioni

Gene expression databases

BgeeiQ15527.
CleanExiHS_SURF2.
GenevestigatoriQ15527.

Organism-specific databases

HPAiHPA044340.
HPA052213.

Interactioni

Protein-protein interaction databases

BioGridi112702. 54 interactions.
IntActiQ15527. 7 interactions.
MINTiMINT-1371424.
STRINGi9606.ENSP00000361032.

Structurei

3D structure databases

ProteinModelPortaliQ15527.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SURF2 family.Curated

Phylogenomic databases

eggNOGiNOG43972.
GeneTreeiENSGT00390000016800.
HOGENOMiHOG000136540.
HOVERGENiHBG054804.
InParanoidiQ15527.
OMAiHLNKLPS.
OrthoDBiEOG7ZKSD9.
PhylomeDBiQ15527.
TreeFamiTF329107.

Family and domain databases

InterProiIPR008833. Surf2.
[Graphical view]
PfamiPF05477. SURF2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15527-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK
60 70 80 90 100
KYQRLVRASP AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH
110 120 130 140 150
TQGRRYQRAL CKYEECQKQG VEYVPACLVH RRRRREDQMD GDGPRPREAF
160 170 180 190 200
WEPTSSDEGG AASDDSMTDL YPPELFTRKD LGSTEDGDGT DDFLTDKEDE
210 220 230 240 250
KAKPPREKAT DESRRETTVY RGLVQKRGKK QLGSLKKKFK SHHRKPKSFS

SCKQPG
Length:256
Mass (Da):29,648
Last modified:January 11, 2011 - v3
Checksum:i5CA1BDEB73CB5127
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti24 – 241A → T in CAA84477. (PubMed:7702754)Curated
Sequence conflicti37 – 371P → T in CAA84477. (PubMed:7702754)Curated
Sequence conflicti142 – 1432DG → EA in CAA84477. (PubMed:7702754)Curated
Sequence conflicti160 – 1601G → A in CAA84477. (PubMed:7702754)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti213 – 2131S → G.2 Publications
Corresponds to variant rs12763 [ dbSNP | Ensembl ].
VAR_014785
Natural varianti221 – 2211R → Q.1 Publication
Corresponds to variant rs7863933 [ dbSNP | Ensembl ].
VAR_057001

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35094 mRNA. Translation: CAA84477.1.
CR456753 mRNA. Translation: CAG33034.1.
AL158826 Genomic DNA. Translation: CAI12838.1.
BC014411 mRNA. Translation: AAH14411.1.
CCDSiCCDS6967.1.
PIRiS57747.
RefSeqiNP_001265857.1. NM_001278928.1.
NP_059973.4. NM_017503.4.
UniGeneiHs.159448.

Genome annotation databases

EnsembliENST00000371964; ENSP00000361032; ENSG00000148291.
GeneIDi6835.
KEGGihsa:6835.
UCSCiuc004cdi.2. human.

Polymorphism databases

DMDMi317373505.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z35094 mRNA. Translation: CAA84477.1 .
CR456753 mRNA. Translation: CAG33034.1 .
AL158826 Genomic DNA. Translation: CAI12838.1 .
BC014411 mRNA. Translation: AAH14411.1 .
CCDSi CCDS6967.1.
PIRi S57747.
RefSeqi NP_001265857.1. NM_001278928.1.
NP_059973.4. NM_017503.4.
UniGenei Hs.159448.

3D structure databases

ProteinModelPortali Q15527.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112702. 54 interactions.
IntActi Q15527. 7 interactions.
MINTi MINT-1371424.
STRINGi 9606.ENSP00000361032.

PTM databases

PhosphoSitei Q15527.

Polymorphism databases

DMDMi 317373505.

Proteomic databases

MaxQBi Q15527.
PaxDbi Q15527.
PRIDEi Q15527.

Protocols and materials databases

DNASUi 6835.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000371964 ; ENSP00000361032 ; ENSG00000148291 .
GeneIDi 6835.
KEGGi hsa:6835.
UCSCi uc004cdi.2. human.

Organism-specific databases

CTDi 6835.
GeneCardsi GC09P136223.
H-InvDB HIX0008504.
HGNCi HGNC:11475. SURF2.
HPAi HPA044340.
HPA052213.
MIMi 185630. gene.
neXtProti NX_Q15527.
PharmGKBi PA36260.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG43972.
GeneTreei ENSGT00390000016800.
HOGENOMi HOG000136540.
HOVERGENi HBG054804.
InParanoidi Q15527.
OMAi HLNKLPS.
OrthoDBi EOG7ZKSD9.
PhylomeDBi Q15527.
TreeFami TF329107.

Miscellaneous databases

ChiTaRSi SURF2. human.
GenomeRNAii 6835.
NextBioi 26683.
PROi Q15527.
SOURCEi Search...

Gene expression databases

Bgeei Q15527.
CleanExi HS_SURF2.
Genevestigatori Q15527.

Family and domain databases

InterProi IPR008833. Surf2.
[Graphical view ]
Pfami PF05477. SURF2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The Surf-1 and Surf-2 genes and their essential bidirectional promoter elements are conserved between mouse and human."
    Lennard A., Gaston K., Fried M.
    DNA Cell Biol. 13:1117-1126(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-213 AND GLN-221.
  2. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-213.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  5. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSURF2_HUMAN
AccessioniPrimary (citable) accession number: Q15527
Secondary accession number(s): Q6IBP9, Q96CD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 11, 2011
Last modified: October 29, 2014
This is version 108 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3