SURF2

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Surfeit locus protein 2 Short name: Surf-2
Gene namesⁱ	Name:SURF2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 9

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11475. SURF2.

HGNCⁱ

HGNC:11475. SURF2.

Subcellular locationⁱ

GO - Cellular componentⁱ

nuclear speck Source: HPA
nucleolus Source: HPA
nucleus Source: HPA
plasma membrane Source: HPA

Complete GO annotation...

Pathology & Biotechⁱ

Organism-specific databases

PharmGKBⁱ	PA36260.

PharmGKBⁱ

PA36260.

Polymorphism and mutation databases

DMDMⁱ	317373505.

DMDMⁱ

317373505.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000072319	1 – 256	Surfeit locus protein 2Add BLAST		256

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	190	PhosphothreonineCombined sources		1
Modified residueⁱ	195	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q15527.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15527.
PaxDbⁱ	Q15527.
PeptideAtlas More...PeptideAtlasⁱ	Q15527.
PRIDEⁱ	Q15527.

PTM databases

iPTMnetⁱ	Q15527.
PhosphoSitePlusⁱ	Q15527.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000148291.
CleanExⁱ	HS_SURF2.
Genevisibleⁱ	Q15527. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA044340. HPA052213.

HPAⁱ

HPA044340.
HPA052213.

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	112702. 56 interactors.
IntActⁱ	Q15527. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1371424.
STRINGⁱ	9606.ENSP00000361032.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q15527.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SURF2 family.Curated

Phylogenomic databases

eggNOGⁱ	ENOG410IK6I. Eukaryota. ENOG4111NE1. LUCA.
HOGENOMⁱ	HOG000136540.
HOVERGENⁱ	HBG054804.
InParanoidⁱ	Q15527.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L5E.
PhylomeDBⁱ	Q15527.
TreeFamⁱ	TF329107.

Family and domain databases

InterProⁱ	View protein in InterPro IPR008833. Surf2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05477. SURF2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

Q15527-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK 
        60         70         80         90        100
KYQRLVRASP AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH 
       110        120        130        140        150
TQGRRYQRAL CKYEECQKQG VEYVPACLVH RRRRREDQMD GDGPRPREAF 
       160        170        180        190        200
WEPTSSDEGG AASDDSMTDL YPPELFTRKD LGSTEDGDGT DDFLTDKEDE 
       210        220        230        240        250
KAKPPREKAT DESRRETTVY RGLVQKRGKK QLGSLKKKFK SHHRKPKSFS 

SCKQPG

Length:256

Mass (Da):29,648

Last modified:January 11, 2011 - v3

Checksum:ⁱ5CA1BDEB73CB5127

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	24	A → T in CAA84477 (PubMed:7702754).Curated	1
Sequence conflictⁱ	37	P → T in CAA84477 (PubMed:7702754).Curated	1
Sequence conflictⁱ	142 – 143	DG → EA in CAA84477 (PubMed:7702754).Curated	2
Sequence conflictⁱ	160	G → A in CAA84477 (PubMed:7702754).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_014785	213	S → G2 PublicationsCorresponds to variant dbSNP:rs12763Ensembl.		1
Natural variantⁱVAR_057001	221	R → Q1 PublicationCorresponds to variant dbSNP:rs7863933Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z35094 mRNA. Translation: CAA84477.1. CR456753 mRNA. Translation: CAG33034.1. AL158826 Genomic DNA. Translation: CAI12838.1. BC014411 mRNA. Translation: AAH14411.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6967.1.
PIRⁱ	S57747.
NCBI Reference Sequences More...RefSeqⁱ	NP_001265857.1. NM_001278928.1. NP_059973.4. NM_017503.4.
UniGeneⁱ	Hs.159448.

Genome annotation databases

Ensemblⁱ	ENST00000371964; ENSP00000361032; ENSG00000148291.
GeneIDⁱ	6835.
KEGGⁱ	hsa:6835.
UCSC genome browser More...UCSCⁱ	uc004cdi.4. human.

Keywords - Coding sequence diversityⁱ

Polymorphism

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	Z35094 mRNA. Translation: CAA84477.1. CR456753 mRNA. Translation: CAG33034.1. AL158826 Genomic DNA. Translation: CAI12838.1. BC014411 mRNA. Translation: AAH14411.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS6967.1.
PIRⁱ	S57747.
NCBI Reference Sequences More...RefSeqⁱ	NP_001265857.1. NM_001278928.1. NP_059973.4. NM_017503.4.
UniGeneⁱ	Hs.159448.

3D structure databases

ProteinModelPortalⁱ	Q15527.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112702. 56 interactors.
IntActⁱ	Q15527. 7 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1371424.
STRINGⁱ	9606.ENSP00000361032.

PTM databases

iPTMnetⁱ	Q15527.
PhosphoSitePlusⁱ	Q15527.

Polymorphism and mutation databases

DMDMⁱ	317373505.

DMDMⁱ

317373505.

Proteomic databases

EPDⁱ	Q15527.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15527.
PaxDbⁱ	Q15527.
PeptideAtlas More...PeptideAtlasⁱ	Q15527.
PRIDEⁱ	Q15527.

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6835.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000371964; ENSP00000361032; ENSG00000148291.
GeneIDⁱ	6835.
KEGGⁱ	hsa:6835.
UCSC genome browser More...UCSCⁱ	uc004cdi.4. human.

Organism-specific databases

CTDⁱ	6835.
GeneCardsⁱ	SURF2.
H-InvDBⁱ	HIX0008504.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11475. SURF2.
Human Protein Atlas More...HPAⁱ	HPA044340. HPA052213.
MIMⁱ	185630. gene.
neXtProtⁱ	NX_Q15527.
PharmGKBⁱ	PA36260.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IK6I. Eukaryota. ENOG4111NE1. LUCA.
HOGENOMⁱ	HOG000136540.
HOVERGENⁱ	HBG054804.
InParanoidⁱ	Q15527.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L5E.
PhylomeDBⁱ	Q15527.
TreeFamⁱ	TF329107.

Miscellaneous databases

ChiTaRSⁱ	SURF2. human.
GenomeRNAiⁱ	6835.
Protein Ontology More...PROⁱ	PR:Q15527.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000148291.
CleanExⁱ	HS_SURF2.
Genevisibleⁱ	Q15527. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR008833. Surf2.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF05477. SURF2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SURF2_HUMAN
Accessionⁱ	Q15527Primary (citable) accession number: Q15527 Secondary accession number(s): Q6IBP9, Q96CD1
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
	Last sequence update:	January 11, 2011
	Last modified:	March 15, 2017
	This is version 127 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 9
Human chromosome 9: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15527 (SURF2_HUMAN)

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Surfeit locus protein 2

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<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Experimental Info

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ