Q15527 (SURF2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Surfeit locus protein 2
Short name=Surf-2

Gene names

Name:

SURF2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	256 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the SURF2 family.

Ontologies

Keywords
Coding sequence diversity	Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	nucleolus Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA plasma membrane Inferred from direct assay. Source: HPA
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 256	256	Surfeit locus protein 2		PRO_0000072319
Amino acid modifications
	Modified residue	190	1	Phosphothreonine Ref.5 Ref.7 Ref.8 Ref.9
	Modified residue	195	1	Phosphothreonine Ref.5 Ref.7 Ref.9
Natural variations
	Natural variant	213	1	S → G. Ref.1 Ref.2 Corresponds to variant rs12763 [ dbSNP | Ensembl ].		VAR_014785
	Natural variant	221	1	R → Q. Ref.1 Corresponds to variant rs7863933 [ dbSNP | Ensembl ].		VAR_057001
Experimental info
	Sequence conflict	24	1	A → T in CAA84477. Ref.1
	Sequence conflict	37	1	P → T in CAA84477. Ref.1
	Sequence conflict	142 – 143	2	DG → EA in CAA84477. Ref.1
	Sequence conflict	160	1	G → A in CAA84477. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q15527 [UniParc]. Last modified January 11, 2011. Version 3. Checksum: 5CA1BDEB73CB5127	FASTA	256	29,648
	10 20 30 40 50 60 MSELPGDVRA FLREHPSLRL QTDARKVRCI LTGHELPCRL PELQVYTRGK KYQRLVRASP 70 80 90 100 110 120 AFDYAEFEPH IVPSTKNPHQ LFCKLTLRHI NKCPEHVLRH TQGRRYQRAL CKYEECQKQG 130 140 150 160 170 180 VEYVPACLVH RRRRREDQMD GDGPRPREAF WEPTSSDEGG AASDDSMTDL YPPELFTRKD 190 200 210 220 230 240 LGSTEDGDGT DDFLTDKEDE KAKPPREKAT DESRRETTVY RGLVQKRGKK QLGSLKKKFK 250 SHHRKPKSFS SCKQPG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The Surf-1 and Surf-2 genes and their essential bidirectional promoter elements are conserved between mouse and human." Lennard A., Gaston K., Fried M. DNA Cell Biol. 13:1117-1126(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS GLY-213 AND GLN-221.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-213.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Lung.
[5]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[6]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[7]	"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions." Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K. Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Leukemic T-cell.
[8]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. Tissue: Cervix carcinoma.
[9]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-190 AND THR-195, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Z35094 mRNA. Translation: CAA84477.1. CR456753 mRNA. Translation: CAG33034.1. AL158826 Genomic DNA. Translation: CAI12838.1. BC014411 mRNA. Translation: AAH14411.1.
PIR	S57747.
RefSeq	NP_001265857.1. NM_001278928.1. NP_059973.4. NM_017503.4.
UniGene	Hs.159448.
3D structure databases
ProteinModelPortal	Q15527.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
BioGrid	112702. 28 interactions.
IntAct	Q15527. 7 interactions.
MINT	MINT-1371424.
STRING	9606.ENSP00000361032.
PTM databases
PhosphoSite	Q15527.
Polymorphism databases
DMDM	317373505.
Proteomic databases
PaxDb	Q15527.
PRIDE	Q15527.
Protocols and materials databases
DNASU	6835.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000371964; ENSP00000361032; ENSG00000148291. ENST00000566819; ENSP00000457376; ENSG00000261361.
GeneID	6835.
KEGG	hsa:6835.
UCSC	uc004cdi.2. human.
Organism-specific databases
CTD	6835.
GeneCards	GC09P136223.
H-InvDB	HIX0008504.
HGNC	HGNC:11475. SURF2.
HPA	HPA044340. HPA052213.
MIM	185630. gene.
neXtProt	NX_Q15527.
PharmGKB	PA36260.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG43972.
HOGENOM	HOG000136540.
HOVERGEN	HBG054804.
InParanoid	Q15527.
OMA	IARWEEC.
OrthoDB	EOG7ZKSD9.
PhylomeDB	Q15527.
TreeFam	TF329107.
Gene expression databases
Bgee	Q15527.
CleanEx	HS_SURF2.
Genevestigator	Q15527.
Family and domain databases
InterPro	IPR008833. Surf2. [Graphical view]
Pfam	PF05477. SURF2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SURF2. human.
GenomeRNAi	6835.
NextBio	26683.
PRO	Q15527.
SOURCE	Search...

Entry information

Entry name

SURF2_HUMAN

Accession

Primary (citable) accession number: Q15527
Secondary accession number(s): Q6IBP9, Q96CD1

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 11, 2011
Last modified:	April 16, 2014
This is version 103 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.