Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q15526

- SURF1_HUMAN

UniProt

Q15526 - SURF1_HUMAN

Protein

Surfeit locus protein 1

Gene

SURF1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Probably involved in the biogenesis of the COX complex.

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: ProtInc
    2. protein binding Source: IntAct

    GO - Biological processi

    1. aerobic respiration Source: ProtInc
    2. ATP biosynthetic process Source: BHF-UCL
    3. hydrogen ion transmembrane transport Source: GOC
    4. oxidation-reduction process Source: ProtInc
    5. oxidative phosphorylation Source: BHF-UCL
    6. respiratory chain complex IV assembly Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Surfeit locus protein 1
    Gene namesi
    Name:SURF1
    Synonyms:SURF-1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:11474. SURF1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial respiratory chain Source: ProtInc

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    Pathology & Biotechi

    Involvement in diseasei

    Leigh syndrome (LS) [MIM:256000]: An early-onset progressive neurodegenerative disorder characterized by the presence of focal, bilateral lesions in one or more areas of the central nervous system including the brainstem, thalamus, basal ganglia, cerebellum and spinal cord. Clinical features depend on which areas of the central nervous system are involved and include subacute onset of psychomotor retardation, hypotonia, ataxia, weakness, vision loss, eye movement abnormalities, seizures, and dysphagia.7 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti56 – 561A → G Found in a patient with LS; unknown pathological significance. 1 Publication
    Corresponds to variant rs116779216 [ dbSNP | Ensembl ].
    VAR_068648
    Natural varianti90 – 901L → P in LS. 1 Publication
    VAR_068649
    Natural varianti124 – 1241G → E in LS. 1 Publication
    Corresponds to variant rs28933402 [ dbSNP | Ensembl ].
    VAR_007450
    Natural varianti124 – 1241G → R in LS.
    VAR_015258
    Natural varianti177 – 1771V → G in LS. 1 Publication
    VAR_068650
    Natural varianti205 – 2051G → E in LS. 1 Publication
    VAR_068651
    Natural varianti227 – 2271W → R in LS; unknown pathological significance. 1 Publication
    VAR_068682
    Natural varianti235 – 2351M → T in LS. 1 Publication
    VAR_068652
    Natural varianti246 – 2461I → T in LS. 1 Publication
    VAR_007452
    Natural varianti248 – 2481A → D in LS. 1 Publication
    VAR_068653
    Natural varianti257 – 2571G → R in LS. 1 Publication
    VAR_068654
    Natural varianti274 – 2741Y → D in LS. 1 Publication
    VAR_015259

    Keywords - Diseasei

    Disease mutation, Leigh syndrome

    Organism-specific databases

    MIMi256000. phenotype.
    Orphaneti1561. Fatal infantile cytochrome C oxidase deficiency.
    70474. Leigh syndrome with cardiomyopathy.
    255241. Leigh syndrome with leukodystrophy.
    391351. SURF1-related Charcot-Marie-Tooth disease type 4.
    PharmGKBiPA36259.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 300300Surfeit locus protein 1PRO_0000215652Add
    BLAST

    Proteomic databases

    MaxQBiQ15526.
    PaxDbiQ15526.
    PRIDEiQ15526.

    PTM databases

    PhosphoSiteiQ15526.

    Expressioni

    Gene expression databases

    ArrayExpressiQ15526.
    BgeeiQ15526.
    CleanExiHS_SURF1.
    GenevestigatoriQ15526.

    Organism-specific databases

    HPAiCAB033946.
    HPA021029.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    COA3Q9Y2R06EBI-3915286,EBI-6570446

    Protein-protein interaction databases

    BioGridi112701. 18 interactions.
    IntActiQ15526. 6 interactions.
    STRINGi9606.ENSP00000361042.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15526.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei61 – 7919HelicalSequence AnalysisAdd
    BLAST
    Transmembranei274 – 29017HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the SURF1 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG3346.
    HOGENOMiHOG000097776.
    HOVERGENiHBG058486.
    InParanoidiQ15526.
    KOiK14998.
    OMAiMVVTPLE.
    OrthoDBiEOG7VQJF0.
    PhylomeDBiQ15526.
    TreeFamiTF314684.

    Family and domain databases

    InterProiIPR002994. Surf1/Shy1.
    [Graphical view]
    PfamiPF02104. SURF1. 1 hit.
    [Graphical view]
    PROSITEiPS50895. SURF1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15526-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAVAALQLG LRAAGLGRAP ASAAWRSVLR VSPRPGVAWR PSRCGSSAAE    50
    ASATKAEDDS FLQWVLLLIP VTAFGLGTWQ VQRRKWKLNL IAELESRVLA 100
    EPVPLPADPM ELKNLEYRPV KVRGCFDHSK ELYMMPRTMV DPVREAREGG 150
    LISSSTQSGA YVVTPFHCTD LGVTILVNRG FVPRKKVNPE TRQKGQIEGE 200
    VDLIGMVRLT ETRQPFVPEN NPERNHWHYR DLEAMARITG AEPIFIDANF 250
    QSTVPGGPIG GQTRVTLRNE HLQYIVTWYG LSAATSYLWF KKFLRGTPGV 300
    Length:300
    Mass (Da):33,331
    Last modified:November 1, 1996 - v1
    Checksum:iEC890EA48A0EDE7A
    GO
    Isoform 2 (identifier: Q15526-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         173-184: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:288
    Mass (Da):31,979
    Checksum:iFF30182CA2C1EE6C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti56 – 561A → G Found in a patient with LS; unknown pathological significance. 1 Publication
    Corresponds to variant rs116779216 [ dbSNP | Ensembl ].
    VAR_068648
    Natural varianti89 – 891N → K in a breast cancer sample; somatic mutation. 1 Publication
    VAR_036340
    Natural varianti90 – 901L → P in LS. 1 Publication
    VAR_068649
    Natural varianti124 – 1241G → E in LS. 1 Publication
    Corresponds to variant rs28933402 [ dbSNP | Ensembl ].
    VAR_007450
    Natural varianti124 – 1241G → R in LS.
    VAR_015258
    Natural varianti177 – 1771V → G in LS. 1 Publication
    VAR_068650
    Natural varianti202 – 2021D → H.1 Publication
    Corresponds to variant rs72619327 [ dbSNP | Ensembl ].
    VAR_007451
    Natural varianti205 – 2051G → E in LS. 1 Publication
    VAR_068651
    Natural varianti227 – 2271W → R in LS; unknown pathological significance. 1 Publication
    VAR_068682
    Natural varianti235 – 2351M → T in LS. 1 Publication
    VAR_068652
    Natural varianti246 – 2461I → T in LS. 1 Publication
    VAR_007452
    Natural varianti248 – 2481A → D in LS. 1 Publication
    VAR_068653
    Natural varianti257 – 2571G → R in LS. 1 Publication
    VAR_068654
    Natural varianti274 – 2741Y → D in LS. 1 Publication
    VAR_015259

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei173 – 18412Missing in isoform 2. CuratedVSP_034817Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35093 mRNA. Translation: CAA84476.1.
    AK291122 mRNA. Translation: BAF83811.1.
    AL158826 Genomic DNA. Translation: CAI12836.1.
    AL158826 Genomic DNA. Translation: CAI12837.1.
    BC028314 mRNA. Translation: AAH28314.1.
    BC071658 mRNA. Translation: AAH71658.1.
    CCDSiCCDS6966.1. [Q15526-1]
    PIRiS57749.
    RefSeqiNP_001267716.1. NM_001280787.1.
    NP_003163.1. NM_003172.3. [Q15526-1]
    UniGeneiHs.512464.

    Genome annotation databases

    EnsembliENST00000371974; ENSP00000361042; ENSG00000148290. [Q15526-1]
    GeneIDi6834.
    KEGGihsa:6834.
    UCSCiuc004cdh.1. human. [Q15526-1]

    Polymorphism databases

    DMDMi2498973.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Surfeit 1 (SURF1)

    Leiden Open Variation Database (LOVD)

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z35093 mRNA. Translation: CAA84476.1 .
    AK291122 mRNA. Translation: BAF83811.1 .
    AL158826 Genomic DNA. Translation: CAI12836.1 .
    AL158826 Genomic DNA. Translation: CAI12837.1 .
    BC028314 mRNA. Translation: AAH28314.1 .
    BC071658 mRNA. Translation: AAH71658.1 .
    CCDSi CCDS6966.1. [Q15526-1 ]
    PIRi S57749.
    RefSeqi NP_001267716.1. NM_001280787.1.
    NP_003163.1. NM_003172.3. [Q15526-1 ]
    UniGenei Hs.512464.

    3D structure databases

    ProteinModelPortali Q15526.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112701. 18 interactions.
    IntActi Q15526. 6 interactions.
    STRINGi 9606.ENSP00000361042.

    PTM databases

    PhosphoSitei Q15526.

    Polymorphism databases

    DMDMi 2498973.

    Proteomic databases

    MaxQBi Q15526.
    PaxDbi Q15526.
    PRIDEi Q15526.

    Protocols and materials databases

    DNASUi 6834.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000371974 ; ENSP00000361042 ; ENSG00000148290 . [Q15526-1 ]
    GeneIDi 6834.
    KEGGi hsa:6834.
    UCSCi uc004cdh.1. human. [Q15526-1 ]

    Organism-specific databases

    CTDi 6834.
    GeneCardsi GC09M136218.
    HGNCi HGNC:11474. SURF1.
    HPAi CAB033946.
    HPA021029.
    MIMi 185620. gene.
    256000. phenotype.
    neXtProti NX_Q15526.
    Orphaneti 1561. Fatal infantile cytochrome C oxidase deficiency.
    70474. Leigh syndrome with cardiomyopathy.
    255241. Leigh syndrome with leukodystrophy.
    391351. SURF1-related Charcot-Marie-Tooth disease type 4.
    PharmGKBi PA36259.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG3346.
    HOGENOMi HOG000097776.
    HOVERGENi HBG058486.
    InParanoidi Q15526.
    KOi K14998.
    OMAi MVVTPLE.
    OrthoDBi EOG7VQJF0.
    PhylomeDBi Q15526.
    TreeFami TF314684.

    Miscellaneous databases

    GeneWikii SURF1.
    GenomeRNAii 6834.
    NextBioi 26679.
    PROi Q15526.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15526.
    Bgeei Q15526.
    CleanExi HS_SURF1.
    Genevestigatori Q15526.

    Family and domain databases

    InterProi IPR002994. Surf1/Shy1.
    [Graphical view ]
    Pfami PF02104. SURF1. 1 hit.
    [Graphical view ]
    PROSITEi PS50895. SURF1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The Surf-1 and Surf-2 genes and their essential bidirectional promoter elements are conserved between mouse and human."
      Lennard A., Gaston K., Fried M.
      DNA Cell Biol. 13:1117-1126(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Colon, Kidney, Skin and Stomach.
    5. "SURF1, encoding a factor involved in the biogenesis of cytochrome c oxidase, is mutated in Leigh syndrome."
      Zhu Z., Yao J., Johns T., Fu K., de Bie I., Macmillan C., Cuthbert A.P., Newbold R.F., Wang J., Chevrette M., Brown G.K., Brown R.M., Shoubridge E.A.
      Nat. Genet. 20:337-343(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: POSSIBLE FUNCTION, INVOLVEMENT IN LS.
    6. "Mutations in the SURF1 gene associated with Leigh syndrome and cytochrome C oxidase deficiency."
      Pequignot M.O., Dey R., Zeviani M., Tiranti V., Godinot C., Poyau A., Sue C., Di Mauro S., Abitbol M., Marsac C.
      Hum. Mutat. 17:374-381(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON LS VARIANTS.
    7. "Missense mutations in SURF1 associated with deficient cytochrome c oxidase assembly in Leigh syndrome patients."
      Poyau A., Buchet K., Bouzidi M.F., Zabot M.-T., Echenne B., Yao J., Shoubridge E.A., Godinot C.
      Hum. Genet. 106:194-205(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LS GLU-124 AND THR-246, VARIANT HIS-202.
    8. "Two novel mutations of SURF1 in Leigh syndrome with cytochrome c oxidase deficiency."
      Teraoka M., Yokoyama Y., Ninomiya S., Inoue C., Yamashita S., Seino Y.
      Hum. Genet. 105:560-563(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LS ASP-274.
    9. "SURF1 gene mutations in Polish patients with COX-deficient Leigh syndrome."
      Piekutowska-Abramczuk D., Popowska E., Pronicka E., Karczmarewicz E., Pronicki M., Kmiec T., Krajewska-Walasek M.
      J. Appl. Genet. 42:103-108(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LS THR-235.
    10. Cited for: VARIANT [LARGE SCALE ANALYSIS] LYS-89.
    11. Cited for: VARIANT LS ARG-227.
    12. Cited for: VARIANT LS ASP-248.
    13. "SURF1-associated leigh syndrome: A case series and novel mutations."
      Lee I.C., El-Hattab A.W., Wang J., Li F.Y., Weng S.W., Craigen W.J., Wong L.J.
      Hum. Mutat. 33:1192-1200(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS LS PRO-90; GLY-177; GLU-205 AND ARG-257, VARIANT GLY-56.

    Entry informationi

    Entry nameiSURF1_HUMAN
    AccessioniPrimary (citable) accession number: Q15526
    Secondary accession number(s): Q5T8T3, Q5T8T4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 126 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3