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Protein

Sperm surface protein Sp17

Gene

SPA17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).By similarity

GO - Biological processi

  • binding of sperm to zona pellucida Source: InterPro
  • epithelial cilium movement Source: BHF-UCL
  • single fertilization Source: ProtInc
  • spermatogenesis Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Sperm surface protein Sp17
Alternative name(s):
Cancer/testis antigen 22
Short name:
CT22
Sp17-1
Sperm autoantigenic protein 17
Short name:
Sperm protein 17
Gene namesi
Name:SPA17
Synonyms:SP17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11210. SPA17.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: BHF-UCL
  • external side of plasma membrane Source: Ensembl
  • motile cilium Source: BHF-UCL
  • primary cilium Source: BHF-UCL
  • sperm fibrous sheath Source: GO_Central
  • sperm principal piece Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36047.

Polymorphism and mutation databases

BioMutaiSPA17.
DMDMi2833264.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 151151Sperm surface protein Sp17PRO_0000181340Add
BLAST

Proteomic databases

EPDiQ15506.
MaxQBiQ15506.
PaxDbiQ15506.
PRIDEiQ15506.
TopDownProteomicsiQ15506.

PTM databases

PhosphoSiteiQ15506.

Expressioni

Tissue specificityi

Testis and sperm specific.

Gene expression databases

BgeeiQ15506.
CleanExiHS_SPA17.
GenevisibleiQ15506. HS.

Organism-specific databases

HPAiHPA037568.

Interactioni

Subunit structurei

Homodimer (By similarity). May interact with ROPN1.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
AKAP7O43687-23EBI-1377865,EBI-10185182
MYL6BP146493EBI-1377865,EBI-358570
ROPN1Q9HAT06EBI-1377865,EBI-1378139

Protein-protein interaction databases

BioGridi119741. 13 interactions.
IntActiQ15506. 3 interactions.
STRINGi9606.ENSP00000227135.

Structurei

3D structure databases

ProteinModelPortaliQ15506.
SMRiQ15506. Positions 12-50.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini114 – 14330IQPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 IQ domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IX7J. Eukaryota.
ENOG410XXA6. LUCA.
GeneTreeiENSGT00440000039164.
HOGENOMiHOG000059525.
HOVERGENiHBG003879.
InParanoidiQ15506.
OMAiFKEQEPP.
OrthoDBiEOG7R2BHX.
PhylomeDBiQ15506.
TreeFamiTF332959.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR000048. IQ_motif_EF-hand-BS.
IPR012105. Sp17.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFiPIRSF016533. Sp17. 1 hit.
SMARTiSM00015. IQ. 1 hit.
SM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15506-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSIPFSNTHY RIPQGFGNLL EGLTREILRE QPDNIPAFAA AYFESLLEKR
60 70 80 90 100
EKTNFDPAEW GSKVEDRFYN NHAFEEQEPP EKSDPKQEES QISGKEEETS
110 120 130 140 150
VTILDSSEED KEKEEVAAVK IQAAFRGHIA REEAKKMKTN SLQNEEKEEN

K
Length:151
Mass (Da):17,406
Last modified:November 1, 1996 - v1
Checksum:iBC99EC310FA0E54A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48570 mRNA. Translation: CAA88459.1.
AF334735 mRNA. Translation: AAK20878.1.
AF334810 Genomic DNA. Translation: AAK28125.1.
AK311806 mRNA. Translation: BAG34749.1.
CH471065 Genomic DNA. Translation: EAW67592.1.
BC032457 mRNA. Translation: AAH32457.1.
CCDSiCCDS8450.1.
PIRiI38243.
RefSeqiNP_059121.1. NM_017425.3.
XP_011541172.1. XM_011542870.1.
UniGeneiHs.286233.

Genome annotation databases

EnsembliENST00000227135; ENSP00000227135; ENSG00000064199.
ENST00000532692; ENSP00000432305; ENSG00000064199.
GeneIDi53340.
KEGGihsa:53340.
UCSCiuc001qap.4. human.

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48570 mRNA. Translation: CAA88459.1.
AF334735 mRNA. Translation: AAK20878.1.
AF334810 Genomic DNA. Translation: AAK28125.1.
AK311806 mRNA. Translation: BAG34749.1.
CH471065 Genomic DNA. Translation: EAW67592.1.
BC032457 mRNA. Translation: AAH32457.1.
CCDSiCCDS8450.1.
PIRiI38243.
RefSeqiNP_059121.1. NM_017425.3.
XP_011541172.1. XM_011542870.1.
UniGeneiHs.286233.

3D structure databases

ProteinModelPortaliQ15506.
SMRiQ15506. Positions 12-50.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi119741. 13 interactions.
IntActiQ15506. 3 interactions.
STRINGi9606.ENSP00000227135.

PTM databases

PhosphoSiteiQ15506.

Polymorphism and mutation databases

BioMutaiSPA17.
DMDMi2833264.

Proteomic databases

EPDiQ15506.
MaxQBiQ15506.
PaxDbiQ15506.
PRIDEiQ15506.
TopDownProteomicsiQ15506.

Protocols and materials databases

DNASUi53340.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000227135; ENSP00000227135; ENSG00000064199.
ENST00000532692; ENSP00000432305; ENSG00000064199.
GeneIDi53340.
KEGGihsa:53340.
UCSCiuc001qap.4. human.

Organism-specific databases

CTDi53340.
GeneCardsiSPA17.
HGNCiHGNC:11210. SPA17.
HPAiHPA037568.
MIMi608621. gene.
neXtProtiNX_Q15506.
PharmGKBiPA36047.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IX7J. Eukaryota.
ENOG410XXA6. LUCA.
GeneTreeiENSGT00440000039164.
HOGENOMiHOG000059525.
HOVERGENiHBG003879.
InParanoidiQ15506.
OMAiFKEQEPP.
OrthoDBiEOG7R2BHX.
PhylomeDBiQ15506.
TreeFamiTF332959.

Miscellaneous databases

GeneWikiiSPA17.
GenomeRNAii53340.
NextBioi55970.
PROiQ15506.
SOURCEiSearch...

Gene expression databases

BgeeiQ15506.
CleanExiHS_SPA17.
GenevisibleiQ15506. HS.

Family and domain databases

InterProiIPR003117. cAMP_dep_PK_reg_su_I/II_a/b.
IPR000048. IQ_motif_EF-hand-BS.
IPR012105. Sp17.
[Graphical view]
PfamiPF00612. IQ. 1 hit.
PF02197. RIIa. 1 hit.
[Graphical view]
PIRSFiPIRSF016533. Sp17. 1 hit.
SMARTiSM00015. IQ. 1 hit.
SM00394. RIIa. 1 hit.
[Graphical view]
SUPFAMiSSF47391. SSF47391. 1 hit.
PROSITEiPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing of cDNAs encoding the human sperm protein, Sp17."
    Lea I.A., Richardson R.T., Widgren E.E., O'Rand M.G.
    Biochim. Biophys. Acta 1307:263-266(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Genomic organization of an intron-containing sperm protein 17 gene (Sp17-1) and an intronless pseudogene (Sp17-2) in humans: a new model."
    Buchli R., De Jong A., Robbins D.L.
    Biochim. Biophys. Acta 1578:29-42(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  6. "A yeast two-hybrid system using Sp17 identified ropporin as a novel cancer-testis antigen in hematologic malignancies."
    Li Z., Li W., Meklat F., Wang Z., Zhang J., Zhang Y., Lim S.H.
    Int. J. Cancer 121:1507-1511(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: POSSIBLE INTERACTION WITH ROPN1.

Entry informationi

Entry nameiSP17_HUMAN
AccessioniPrimary (citable) accession number: Q15506
Secondary accession number(s): B2R4F2, Q9BXF7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: March 16, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.