ID   GUSP1_HUMAN             Reviewed;         140 AA.
AC   Q15486; A6NLY8; A8K1B7; Q969T8; Q9BUH2;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   02-SEP-2008, sequence version 3.
DT   13-SEP-2023, entry version 157.
DE   RecName: Full=Putative inactive beta-glucuronidase-like protein SMA3;
GN   Name=GUSBP1; Synonyms=SMA3;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Fetal brain;
RX   PubMed=7977382;
RA   Theodosiou A.M., Morrison K.E., Nesbit A.M., Daniels R.J., Campbell L.,
RA   Francis M.J., Christodoulou Z., Davies K.E.;
RT   "Complex repetitive arrangements of gene sequence in the candidate region
RT   of the spinal muscular atrophy gene in 5q13.";
RL   Am. J. Hum. Genet. 55:1209-1217(1994).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain, and Thymus;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA   Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S.,
RA   Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y.,
RA   Phelan M., Farmer A.;
RT   "Cloning of human full-length CDSs in BD Creator(TM) system donor vector.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15372022; DOI=10.1038/nature02919;
RA   Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S.,
RA   Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M.,
RA   She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.,
RA   Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M.,
RA   Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M.,
RA   Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A.,
RA   Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R.,
RA   Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L.,
RA   Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N.,
RA   Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J.,
RA   Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A.,
RA   Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.;
RT   "The DNA sequence and comparative analysis of human chromosome 5.";
RL   Nature 431:268-274(2004).
CC   -!- INTERACTION:
CC       Q15486; P07550: ADRB2; NbExp=3; IntAct=EBI-712457, EBI-491169;
CC       Q15486; P28329-3: CHAT; NbExp=3; IntAct=EBI-712457, EBI-25837549;
CC       Q15486; G5E9A7: DMWD; NbExp=3; IntAct=EBI-712457, EBI-10976677;
CC       Q15486; P22607: FGFR3; NbExp=4; IntAct=EBI-712457, EBI-348399;
CC       Q15486; P06396: GSN; NbExp=3; IntAct=EBI-712457, EBI-351506;
CC       Q15486; P11021: HSPA5; NbExp=3; IntAct=EBI-712457, EBI-354921;
CC       Q15486; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-712457, EBI-5235340;
CC       Q15486; Q9Y649; NbExp=3; IntAct=EBI-712457, EBI-25900580;
CC   -!- TISSUE SPECIFICITY: Ubiquitous.
CC   -!- SIMILARITY: Belongs to the glycosyl hydrolase 2 family. {ECO:0000305}.
CC   -!- CAUTION: Could be the product of a pseudogene. Compared to other
CC       members of the glycosyl hydrolase 2 family this putative protein is
CC       truncated in both the N- and C-terminal regions and thus probably lacks
CC       enzymatic activity. {ECO:0000305}.
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DR   EMBL; X83299; CAA58278.1; -; mRNA.
DR   EMBL; AK289832; BAF82521.1; -; mRNA.
DR   EMBL; AK315849; BAF98740.1; -; mRNA.
DR   EMBL; BT006760; AAP35406.1; -; mRNA.
DR   EMBL; AL009030; CAC69829.1; -; Genomic_DNA.
DR   EMBL; AL009030; CAC69830.1; -; Genomic_DNA.
DR   PIR; I38232; I38232.
DR   RefSeq; XP_016885720.1; XM_017030231.1.
DR   RefSeq; XP_016885721.1; XM_017030232.1.
DR   RefSeq; XP_016885722.1; XM_017030233.1.
DR   AlphaFoldDB; Q15486; -.
DR   SMR; Q15486; -.
DR   IntAct; Q15486; 14.
DR   iPTMnet; Q15486; -.
DR   PhosphoSitePlus; Q15486; -.
DR   BioMuta; HGNC:13670; -.
DR   DMDM; 205371787; -.
DR   MassIVE; Q15486; -.
DR   PeptideAtlas; Q15486; -.
DR   ProteomicsDB; 60610; -.
DR   AGR; HGNC:13670; -.
DR   GeneCards; GUSBP1; -.
DR   HGNC; HGNC:13670; GUSBP1.
DR   neXtProt; NX_Q15486; -.
DR   InParanoid; Q15486; -.
DR   PhylomeDB; Q15486; -.
DR   PathwayCommons; Q15486; -.
DR   SignaLink; Q15486; -.
DR   ChiTaRS; GUSBP1; human.
DR   GenomeRNAi; 100653061; -.
DR   Pharos; Q15486; Tdark.
DR   Proteomes; UP000005640; Unplaced.
DR   RNAct; Q15486; Protein.
DR   GO; GO:0007399; P:nervous system development; TAS:ProtInc.
DR   GO; GO:0001501; P:skeletal system development; TAS:ProtInc.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR036156; Beta-gal/glucu_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   PANTHER; PTHR10066; BETA-GLUCURONIDASE; 1.
DR   PANTHER; PTHR10066:SF67; BETA-GLUCURONIDASE; 1.
DR   SUPFAM; SSF49303; beta-Galactosidase/glucuronidase domain; 1.
PE   5: Uncertain;
KW   Reference proteome.
FT   CHAIN           1..140
FT                   /note="Putative inactive beta-glucuronidase-like protein
FT                   SMA3"
FT                   /id="PRO_0000057682"
FT   CONFLICT        15
FT                   /note="S -> L (in Ref. 1; CAA58278)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        74
FT                   /note="S -> Y (in Ref. 1; CAA58278 and 3; AAP35406)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   140 AA;  15381 MW;  80CA4B489C81A48D CRC64;
     MDRSNPVKPA LDYFSNRLVN YQISVKCSNQ FKLEVCLLNA ENKVVDNQAG TQGQLKVLGA
     NLWWPYLMHE HPASLYSWED GDCSHQSLGP LPACDLCDQL HLRSRQGGSV CGCDPCEQLL
     LLVSQLRAPG VDSAAAGRPV
//