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Protein

Putative inactive beta-glucuronidase-like protein SMA3

Gene

GUSBP1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein uncertaini

Functioni

GO - Molecular functioni

GO - Biological processi

  • carbohydrate metabolic process Source: InterPro
  • nervous system development Source: ProtInc
  • skeletal system development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Putative inactive beta-glucuronidase-like protein SMA3
Gene namesi
Name:GUSBP1
Synonyms:SMA3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:13670. GUSBP1.

Pathology & Biotechi

Organism-specific databases

DisGeNETi100653061.
728411.

Polymorphism and mutation databases

DMDMi205371787.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000576821 – 140Putative inactive beta-glucuronidase-like protein SMA3Add BLAST140

Proteomic databases

PRIDEiQ15486.

Expressioni

Tissue specificityi

Ubiquitous.

Interactioni

Protein-protein interaction databases

IntActiQ15486. 7 interactors.
MINTiMINT-1373382.

Structurei

3D structure databases

ProteinModelPortaliQ15486.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.Curated

Phylogenomic databases

HOVERGENiHBG051863.
InParanoidiQ15486.
PhylomeDBiQ15486.

Family and domain databases

Gene3Di2.60.40.320. 1 hit.
InterProiIPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15486-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRSNPVKPA LDYFSNRLVN YQISVKCSNQ FKLEVCLLNA ENKVVDNQAG
60 70 80 90 100
TQGQLKVLGA NLWWPYLMHE HPASLYSWED GDCSHQSLGP LPACDLCDQL
110 120 130 140
HLRSRQGGSV CGCDPCEQLL LLVSQLRAPG VDSAAAGRPV
Length:140
Mass (Da):15,381
Last modified:September 2, 2008 - v3
Checksum:i80CA4B489C81A48D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15S → L in CAA58278 (PubMed:7977382).Curated1
Sequence conflicti74S → Y in CAA58278 (PubMed:7977382).Curated1
Sequence conflicti74S → Y in AAP35406 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83299 mRNA. Translation: CAA58278.1.
AK289832 mRNA. Translation: BAF82521.1.
AK315849 mRNA. Translation: BAF98740.1.
BT006760 mRNA. Translation: AAP35406.1.
AL009030 Genomic DNA. Translation: CAC69829.1.
AL009030 Genomic DNA. Translation: CAC69830.1.
PIRiI38232.
RefSeqiXP_016885720.1. XM_017030231.1.
XP_016885721.1. XM_017030232.1.
XP_016885722.1. XM_017030233.1.
UniGeneiHs.582500.
Hs.631974.
Hs.652536.
Hs.654588.

Genome annotation databases

GeneIDi100653061.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83299 mRNA. Translation: CAA58278.1.
AK289832 mRNA. Translation: BAF82521.1.
AK315849 mRNA. Translation: BAF98740.1.
BT006760 mRNA. Translation: AAP35406.1.
AL009030 Genomic DNA. Translation: CAC69829.1.
AL009030 Genomic DNA. Translation: CAC69830.1.
PIRiI38232.
RefSeqiXP_016885720.1. XM_017030231.1.
XP_016885721.1. XM_017030232.1.
XP_016885722.1. XM_017030233.1.
UniGeneiHs.582500.
Hs.631974.
Hs.652536.
Hs.654588.

3D structure databases

ProteinModelPortaliQ15486.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ15486. 7 interactors.
MINTiMINT-1373382.

Polymorphism and mutation databases

DMDMi205371787.

Proteomic databases

PRIDEiQ15486.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100653061.

Organism-specific databases

DisGeNETi100653061.
728411.
GeneCardsiGUSBP1.
HGNCiHGNC:13670. GUSBP1.
neXtProtiNX_Q15486.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG051863.
InParanoidiQ15486.
PhylomeDBiQ15486.

Miscellaneous databases

ChiTaRSiGUSBP1. human.
GenomeRNAii100653061.

Family and domain databases

Gene3Di2.60.40.320. 1 hit.
InterProiIPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiGUSP1_HUMAN
AccessioniPrimary (citable) accession number: Q15486
Secondary accession number(s): A6NLY8
, A8K1B7, Q969T8, Q9BUH2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: September 2, 2008
Last modified: November 30, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene. Compared to other members of the glycosyl hydrolase 2 family this putative protein is truncated in both the N- and C-terminal regions and thus probably lacks enzymatic activity.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.