Q15486 (GUSP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative inactive beta-glucuronidase-like protein SMA3

Gene names

Name:	GUSBP1
Synonyms:	SMA3

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	140 AA.
Sequence status	Complete.
Protein existence	Uncertain

General annotation (Comments)

Tissue specificity	Ubiquitous.
Sequence similarities	Belongs to the glycosyl hydrolase 2 family.
Caution	Could be the product of a pseudogene. Compared to other members of the glycosyl hydrolase 2 family this putative protein is truncated in both the N- and C-terminal regions and thus probably lacks enzymatic activity.

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro nervous system development Traceable author statement Ref.1. Source: ProtInc skeletal system development Traceable author statement Ref.1. Source: ProtInc
Molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 140	140	Putative inactive beta-glucuronidase-like protein SMA3		PRO_0000057682
Experimental info
	Sequence conflict	15	1	S → L in CAA58278. Ref.1
	Sequence conflict	74	1	S → Y in CAA58278. Ref.1
	Sequence conflict	74	1	S → Y in AAP35406. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q15486 [UniParc]. Last modified September 2, 2008. Version 3. Checksum: 80CA4B489C81A48D	FASTA	140	15,381
	10 20 30 40 50 60 MDRSNPVKPA LDYFSNRLVN YQISVKCSNQ FKLEVCLLNA ENKVVDNQAG TQGQLKVLGA 70 80 90 100 110 120 NLWWPYLMHE HPASLYSWED GDCSHQSLGP LPACDLCDQL HLRSRQGGSV CGCDPCEQLL 130 140 LLVSQLRAPG VDSAAAGRPV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Complex repetitive arrangements of gene sequence in the candidate region of the spinal muscular atropy gene in 5q13." Theodosiou A.M., Morrison K.E., Nesbit A.M., Daniels R.J., Campbell L., Francis M.J., Christodoulou Z., Davies K.E. Am. J. Hum. Genet. 55:1209-1217(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Fetal brain.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Thymus.
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"The DNA sequence and comparative analysis of human chromosome 5." Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M. Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X83299 mRNA. Translation: CAA58278.1. AK289832 mRNA. Translation: BAF82521.1. AK315849 mRNA. Translation: BAF98740.1. BT006760 mRNA. Translation: AAP35406.1. AL009030 Genomic DNA. Translation: CAC69829.1. AL009030 Genomic DNA. Translation: CAC69830.1.
IPI	IPI00009534.
PIR	I38232.
RefSeq	XP_003403442.1. XM_003403394.1. XP_003403443.1. XM_003403395.3. XP_003403444.1. XM_003403396.1. XP_003961032.1. XM_003960983.1.
UniGene	Hs.582500. Hs.631974. Hs.652536. Hs.654588.
3D structure databases
ProteinModelPortal	Q15486.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15486. 7 interactions.
MINT	MINT-1373382.
Polymorphism databases
DMDM	205371787.
Proteomic databases
PaxDb	Q15486.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	100653061.
KEGG	hsa:100653061.
Organism-specific databases
GeneCards	GC05P021337.
HGNC	HGNC:13670. GUSBP1.
neXtProt	NX_Q15486.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG281749.
HOVERGEN	HBG051863.
InParanoid	Q15486.
OrthoDB	EOG4CVG86.
PhylomeDB	Q15486.
Gene expression databases
Genevestigator	Q15486.
GermOnline	ENSG00000205570. Homo sapiens. ENSG00000205575. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.320. 1 hit.
InterPro	IPR013812. Glyco_hydro_2/20_Ig-like. IPR006102. Glyco_hydro_2_Ig-like. [Graphical view]
SUPFAM	SSF49303. Glyco_hydro_2Ig. 1 hit.
ProtoNet	Search...
Other
NextBio	34055837.

Entry information

Entry name

GUSP1_HUMAN

Accession

Primary (citable) accession number: Q15486
Secondary accession number(s): A6NLY8 , A8K1B7, Q969T8, Q9BUH2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 5, 2002
Last sequence update:	September 2, 2008
Last modified:	May 1, 2013
This is version 105 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.