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Q15486

- GUSP1_HUMAN

UniProt

Q15486 - GUSP1_HUMAN

Protein

Putative inactive beta-glucuronidase-like protein SMA3

Gene

GUSBP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 2 out of 5- Protein uncertaini
  1. Functioni

    GO - Molecular functioni

    1. hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro
    2. nervous system development Source: ProtInc
    3. skeletal system development Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Putative inactive beta-glucuronidase-like protein SMA3
    Gene namesi
    Name:GUSBP1
    Synonyms:SMA3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:13670. GUSBP1.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 140140Putative inactive beta-glucuronidase-like protein SMA3PRO_0000057682Add
    BLAST

    Proteomic databases

    PaxDbiQ15486.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    GenevestigatoriQ15486.

    Interactioni

    Protein-protein interaction databases

    IntActiQ15486. 7 interactions.
    MINTiMINT-1373382.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15486.
    SMRiQ15486. Positions 18-91.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.Curated

    Phylogenomic databases

    eggNOGiNOG281749.
    HOVERGENiHBG051863.
    InParanoidiQ15486.
    PhylomeDBiQ15486.

    Family and domain databases

    Gene3Di2.60.40.320. 1 hit.
    InterProiIPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q15486-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDRSNPVKPA LDYFSNRLVN YQISVKCSNQ FKLEVCLLNA ENKVVDNQAG    50
    TQGQLKVLGA NLWWPYLMHE HPASLYSWED GDCSHQSLGP LPACDLCDQL 100
    HLRSRQGGSV CGCDPCEQLL LLVSQLRAPG VDSAAAGRPV 140
    Length:140
    Mass (Da):15,381
    Last modified:September 2, 2008 - v3
    Checksum:i80CA4B489C81A48D
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151S → L in CAA58278. (PubMed:7977382)Curated
    Sequence conflicti74 – 741S → Y in CAA58278. (PubMed:7977382)Curated
    Sequence conflicti74 – 741S → Y in AAP35406. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83299 mRNA. Translation: CAA58278.1.
    AK289832 mRNA. Translation: BAF82521.1.
    AK315849 mRNA. Translation: BAF98740.1.
    BT006760 mRNA. Translation: AAP35406.1.
    AL009030 Genomic DNA. Translation: CAC69829.1.
    AL009030 Genomic DNA. Translation: CAC69830.1.
    PIRiI38232.
    RefSeqiXP_006726287.1. XM_006726224.1.
    UniGeneiHs.582500.
    Hs.631974.
    Hs.652536.
    Hs.654588.

    Genome annotation databases

    GeneIDi100653061.
    KEGGihsa:100653061.

    Polymorphism databases

    DMDMi205371787.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83299 mRNA. Translation: CAA58278.1 .
    AK289832 mRNA. Translation: BAF82521.1 .
    AK315849 mRNA. Translation: BAF98740.1 .
    BT006760 mRNA. Translation: AAP35406.1 .
    AL009030 Genomic DNA. Translation: CAC69829.1 .
    AL009030 Genomic DNA. Translation: CAC69830.1 .
    PIRi I38232.
    RefSeqi XP_006726287.1. XM_006726224.1.
    UniGenei Hs.582500.
    Hs.631974.
    Hs.652536.
    Hs.654588.

    3D structure databases

    ProteinModelPortali Q15486.
    SMRi Q15486. Positions 18-91.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q15486. 7 interactions.
    MINTi MINT-1373382.

    Polymorphism databases

    DMDMi 205371787.

    Proteomic databases

    PaxDbi Q15486.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100653061.
    KEGGi hsa:100653061.

    Organism-specific databases

    GeneCardsi GC05P021337.
    HGNCi HGNC:13670. GUSBP1.
    neXtProti NX_Q15486.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG281749.
    HOVERGENi HBG051863.
    InParanoidi Q15486.
    PhylomeDBi Q15486.

    Miscellaneous databases

    NextBioi 34055837.

    Gene expression databases

    Genevestigatori Q15486.

    Family and domain databases

    Gene3Di 2.60.40.320. 1 hit.
    InterProi IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR006102. Glyco_hydro_2_Ig-like.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complex repetitive arrangements of gene sequence in the candidate region of the spinal muscular atropy gene in 5q13."
      Theodosiou A.M., Morrison K.E., Nesbit A.M., Daniels R.J., Campbell L., Francis M.J., Christodoulou Z., Davies K.E.
      Am. J. Hum. Genet. 55:1209-1217(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Thymus.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "The DNA sequence and comparative analysis of human chromosome 5."
      Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S.
      , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
      Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiGUSP1_HUMAN
    AccessioniPrimary (citable) accession number: Q15486
    Secondary accession number(s): A6NLY8
    , A8K1B7, Q969T8, Q9BUH2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 112 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Could be the product of a pseudogene. Compared to other members of the glycosyl hydrolase 2 family this putative protein is truncated in both the N- and C-terminal regions and thus probably lacks enzymatic activity.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Glycosyl hydrolases
      Classification of glycosyl hydrolase families and list of entries
    2. Human chromosome 5
      Human chromosome 5: entries, gene names and cross-references to MIM
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3