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Q15486 (GUSP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Putative inactive beta-glucuronidase-like protein SMA3
Gene names
Name:GUSBP1
Synonyms:SMA3
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length140 AA.
Sequence statusComplete.
Protein existenceUncertain

General annotation (Comments)

Tissue specificity

Ubiquitous.

Sequence similarities

Belongs to the glycosyl hydrolase 2 family.

Caution

Could be the product of a pseudogene. Compared to other members of the glycosyl hydrolase 2 family this putative protein is truncated in both the N- and C-terminal regions and thus probably lacks enzymatic activity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 140140Putative inactive beta-glucuronidase-like protein SMA3
PRO_0000057682

Experimental info

Sequence conflict151S → L in CAA58278. Ref.1
Sequence conflict741S → Y in CAA58278. Ref.1
Sequence conflict741S → Y in AAP35406. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q15486 [UniParc].

Last modified September 2, 2008. Version 3.
Checksum: 80CA4B489C81A48D

FASTA14015,381
        10         20         30         40         50         60 
MDRSNPVKPA LDYFSNRLVN YQISVKCSNQ FKLEVCLLNA ENKVVDNQAG TQGQLKVLGA 

        70         80         90        100        110        120 
NLWWPYLMHE HPASLYSWED GDCSHQSLGP LPACDLCDQL HLRSRQGGSV CGCDPCEQLL 

       130        140 
LLVSQLRAPG VDSAAAGRPV 

« Hide

References

« Hide 'large scale' references
[1]"Complex repetitive arrangements of gene sequence in the candidate region of the spinal muscular atropy gene in 5q13."
Theodosiou A.M., Morrison K.E., Nesbit A.M., Daniels R.J., Campbell L., Francis M.J., Christodoulou Z., Davies K.E.
Am. J. Hum. Genet. 55:1209-1217(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Fetal brain.
[2]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Thymus.
[3]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J., Martin J., Terry A., Couronne O., Grimwood J., Lowry S., Gordon L.A., Scott D., Xie G., Huang W., Hellsten U., Tran-Gyamfi M., She X., Prabhakar S., Aerts A., Altherr M., Bajorek E., Black S. expand/collapse author list , Branscomb E., Caoile C., Challacombe J.F., Chan Y.M., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Lopez F., Lou Y., Martinez D., Medina C., Morgan J., Nandkeshwar R., Noonan J.P., Pitluck S., Pollard M., Predki P., Priest J., Ramirez L., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wheeler J., Wu K., Yang J., Dickson M., Cheng J.-F., Eichler E.E., Olsen A., Pennacchio L.A., Rokhsar D.S., Richardson P., Lucas S.M., Myers R.M., Rubin E.M.
Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X83299 mRNA. Translation: CAA58278.1.
AK289832 mRNA. Translation: BAF82521.1.
AK315849 mRNA. Translation: BAF98740.1.
BT006760 mRNA. Translation: AAP35406.1.
AL009030 Genomic DNA. Translation: CAC69829.1.
AL009030 Genomic DNA. Translation: CAC69830.1.
PIRI38232.
RefSeqXP_006726287.1. XM_006726224.1.
UniGeneHs.582500.
Hs.631974.
Hs.652536.
Hs.654588.

3D structure databases

ProteinModelPortalQ15486.
SMRQ15486. Positions 18-91.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ15486. 7 interactions.
MINTMINT-1373382.

Polymorphism databases

DMDM205371787.

Proteomic databases

PaxDbQ15486.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID100653061.
KEGGhsa:100653061.

Organism-specific databases

GeneCardsGC05P021337.
HGNCHGNC:13670. GUSBP1.
neXtProtNX_Q15486.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG281749.
HOVERGENHBG051863.
InParanoidQ15486.
PhylomeDBQ15486.

Gene expression databases

GenevestigatorQ15486.

Family and domain databases

Gene3D2.60.40.320. 1 hit.
InterProIPR013812. Glyco_hydro_2/20_Ig-like.
IPR006102. Glyco_hydro_2_Ig-like.
[Graphical view]
SUPFAMSSF49303. SSF49303. 1 hit.
ProtoNetSearch...

Other

NextBio34055837.

Entry information

Entry nameGUSP1_HUMAN
AccessionPrimary (citable) accession number: Q15486
Secondary accession number(s): A6NLY8 expand/collapse secondary AC list , A8K1B7, Q969T8, Q9BUH2
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: September 2, 2008
Last modified: May 14, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 5

Human chromosome 5: entries, gene names and cross-references to MIM

Glycosyl hydrolases

Classification of glycosyl hydrolase families and list of entries