Reviewed, UniProtKB/Swiss-Prot Q15468 (STIL_HUMAN)

Names and origin

Protein names

Recommended name:
    SCL-interrupting locus protein
Alternative name(s):
    TAL-1-interrupting locus protein

Gene names

Name:	STIL
Synonyms:	SIL

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1287 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDC2 activity correlated with reduced phosphorylation of CDC2. Play a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Ref.9 Ref.14
Subunit structure	Interacts with PIN1 via its WW domain. This interaction is dependent on STIL mitotic phosphorylation By similarity.
Subcellular location	Cytoplasm › cytosol By similarity.
Tissue specificity	Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer. Ref.1 Ref.13
Induction	Down-regulated when cell proliferation ceased. Accumulates during G2 phase and falls at completion of the cell cycle. Ref.9
Post-translational modification	Phosphorylated following the activation of the mitotic checkpoint. Ref.14 Ref.15 Ref.16
Involvement in disease	A chromosomal aberration involving STIL may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). A deletion at 1p32 between STIL and TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to TAL1 exon 3. As both STIL exon 1 and TAL1 exon 3 are 5'-untranslated exons, STIL/TAL1 fusion mRNA predicts a full length TAL1 protein under the control of the STIL promoter, leading to inappropriate TAL1 expression. In childhood T-cell malignancies (T-ALL), a type of defect such as STIL/TAL1 fusion is associated with a good prognosis. In cultured lymphocytes from healthy adults, STIL/TAL1 fusion mRNA may be detected after 7 days of culture. Defects in STIL are the cause of microcephaly primary type 7 (MCPH7) [MIM:612703]. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits.

Ontologies

Keywords
Cellular component	Cytoplasm
Coding sequence diversity	Alternative splicing Chromosomal rearrangement Polymorphism
Disease	Primary microcephaly Proto-oncogene
Molecular function	Developmental protein
PTM	Phosphoprotein
Gene Ontology (GO)
Biological process	cell proliferation Traceable author statement. Source: ProtInc multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytosol Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15468-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15468-2)

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: N → NS

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1287	1287	SCL-interrupting locus protein		PRO_0000271332
Regions
	Region	584 – 779	196	PIN1-binding By similarity
Amino acid modifications
	Modified residue	753	1	Phosphoserine Ref.16
	Modified residue	1004	1	Phosphoserine Ref.15
Natural variations
	Alternative sequence	872	1	N → NS in isoform 2.		VSP_022301
	Natural variant	86	1	A → V: dbSNP rs3125630. Ref.2 Ref.3		VAR_029870
	Natural variant	984	1	H → R: dbSNP rs13376679. Ref.3		VAR_029871
	Natural variant	1012	1	P → R Ref.2		VAR_029872
	Natural variant	1145	1	A → V: dbSNP rs3766317.		VAR_051386
Experimental info
	Sequence conflict	70 – 71	2	KQ → NE in AAA60550. Ref.1
	Sequence conflict	70 – 71	2	KQ → NE in AAK51418. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified January 9, 2007. Version 2. Checksum: 7F15BEDA8717659C	FASTA	1,287	142,955
	10 20 30 40 50 60 MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 70 80 90 100 110 120 TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 130 140 150 160 170 180 DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 190 200 210 220 230 240 LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 250 260 270 280 290 300 TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 310 320 330 340 350 360 IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 370 380 390 400 410 420 NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 430 440 450 460 470 480 QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 490 500 510 520 530 540 GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 550 560 570 580 590 600 VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 610 620 630 640 650 660 NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 670 680 690 700 710 720 SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 730 740 750 760 770 780 DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 790 800 810 820 830 840 GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 850 860 870 880 890 900 SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNSSLVVRKE PDVPVFFPSG QLAESVSMCL 910 920 930 940 950 960 QTGPTGGASN NSETSEEPKI EHVMQPLLHQ PSDNQKIYQD LLGQVNHLLN SSSKETEQPS 970 980 990 1000 1010 1020 TKAVIISHEC TRTQNVYHTK KKTHHSRLVD KDCVLNATLK QLRSLGVKID SPTKVKKNAH 1030 1040 1050 1060 1070 1080 NVDHASVLAC ISPEAVISGL NCMSFANVGM SGLSPNGVDL SMEANAIALK YLNENQLSQL 1090 1100 1110 1120 1130 1140 SVTRSNQNNC DPFSLLHINT DRSTVGLSLI SPNNMSFATK KYMKRYGLLQ SSDNSEDEEE 1150 1160 1170 1180 1190 1200 PPDNADSKSE YLLNQNLRSI PEQLGGQKEP SKNDHEIINC SNCESVGTNA DTPVLRNITN 1210 1220 1230 1240 1250 1260 EVLQTKAKQQ LTEKPAFLVK NLKPSPAVNL RTGKAEFTQH PEKENEGDIT IFPESLQPSE 1270 1280 TLKQMNSMNS VGTFLDVKRL RQLPKLF
	Isoform 2. Checksum: 56143155E2FBA492	FASTA	1,288	143,042
	10 20 30 40 50 60 MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 70 80 90 100 110 120 TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 130 140 150 160 170 180 DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 190 200 210 220 230 240 LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 250 260 270 280 290 300 TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 310 320 330 340 350 360 IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 370 380 390 400 410 420 NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 430 440 450 460 470 480 QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 490 500 510 520 530 540 GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 550 560 570 580 590 600 VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 610 620 630 640 650 660 NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 670 680 690 700 710 720 SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 730 740 750 760 770 780 DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 790 800 810 820 830 840 GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 850 860 870 880 890 900 SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNSSSLVVRK EPDVPVFFPS GQLAESVSMC 910 920 930 940 950 960 LQTGPTGGAS NNSETSEEPK IEHVMQPLLH QPSDNQKIYQ DLLGQVNHLL NSSSKETEQP 970 980 990 1000 1010 1020 STKAVIISHE CTRTQNVYHT KKKTHHSRLV DKDCVLNATL KQLRSLGVKI DSPTKVKKNA 1030 1040 1050 1060 1070 1080 HNVDHASVLA CISPEAVISG LNCMSFANVG MSGLSPNGVD LSMEANAIAL KYLNENQLSQ 1090 1100 1110 1120 1130 1140 LSVTRSNQNN CDPFSLLHIN TDRSTVGLSL ISPNNMSFAT KKYMKRYGLL QSSDNSEDEE 1150 1160 1170 1180 1190 1200 EPPDNADSKS EYLLNQNLRS IPEQLGGQKE PSKNDHEIIN CSNCESVGTN ADTPVLRNIT 1210 1220 1230 1240 1250 1260 NEVLQTKAKQ QLTEKPAFLV KNLKPSPAVN LRTGKAEFTQ HPEKENEGDI TIFPESLQPS 1270 1280 ETLKQMNSMN SVGTFLDVKR LRQLPKLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia." Aplan P.D., Lombardi D.P., Kirsch I.R. Mol. Cell. Biol. 11:5462-5469(1991) [PubMed: 1922059] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL REARRANGEMENT, TISSUE SPECIFICITY. Tissue: Bone marrow.
[2]	"The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly." Karkera J.D., Izraeli S., Roessler E., Dutra A., Kirsch I.R., Muenke M. Cytogenet. Genome Res. 97:62-67(2002) [PubMed: 12438740] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), VARIANTS VAL-86 AND ARG-1012.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Blocker H., Heubner D., Hoerlein A., Michel G., Wedler H., Kohrer K., Ottenwalder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed: 17974005] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS VAL-86 AND ARG-984. Tissue: Uterus.
[4]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia." Brown L., Cheng J.-T., Chen Q., Siciliano M.J., Crist W., Buchanan G., Baer R. EMBO J. 9:3343-3351(1990) [PubMed: 2209547] [Abstract] Cited for: CHROMOSOMAL REARRANGEMENT.
[7]	"Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity." Aplan P.D., Lombardi D.P., Ginsberg A.M., Cossman J., Bertness V.L., Kirsch I.R. Science 250:1426-1429(1990) [PubMed: 2255914] [Abstract] Cited for: CHROMOSOMAL REARRANGEMENT.
[8]	"Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia." Aplan P.D., Lombardi D.P., Reaman G.H., Sather H.N., Hammond G.D., Kirsch I.R. Blood 79:1327-1333(1992) [PubMed: 1311214] [Abstract] Cited for: CHROMOSOMAL REARRANGEMENT.
[9]	"Expression of the SIL gene is correlated with growth induction and cellular proliferation." Izraeli S., Colaizzo-Anas T., Bertness V.L., Mani K., Aplan P.D., Kirsch I.R. Cell Growth Differ. 8:1171-1179(1997) [PubMed: 9372240] [Abstract] Cited for: FUNCTION, INDUCTION.
[10]	"Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints." Raghavan S.C., Kirsch I.R., Lieber M.R. J. Biol. Chem. 276:29126-29133(2001) [PubMed: 11390401] [Abstract] Cited for: CHROMOSOMAL REARRANGEMENT.
[11]	"Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR." Curry J.D., Smith M.T. Leuk. Res. 27:575-582(2003) [PubMed: 12681356] [Abstract] Cited for: CHROMOSOMAL REARRANGEMENT.
[12]	"Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951." Cave H., Suciu S., Preudhomme C., Poppe B., Robert A., Uyttebroeck A., Malet M., Boutard P., Benoit Y., Mauvieux L., Lutz P., Mechinaud F., Grardel N., Mazingue F., Dupont M., Margueritte G., Pages M.-P., Bertrand Y. , Plouvier E., Brunie G., Bastard C., Plantaz D., Vande Velde I., Hagemeijer A., Speleman F., Lessard M., Otten J., Vilmer E., Dastugue N. Blood 103:442-450(2004) [PubMed: 14504110] [Abstract] Cited for: CHROMOSOMAL REARRANGEMENT.
[13]	"Sil overexpression in lung cancer characterizes tumors with increased mitotic activity." Erez A., Perelman M., Hewitt S.M., Cojacaru G., Goldberg I., Shahar I., Yaron P., Muler I., Campaner S., Amariglio N., Rechavi G., Kirsch I.R., Krupsky M., Kaminski N., Izraeli S. Oncogene 23:5371-5377(2004) [PubMed: 15107824] [Abstract] Cited for: TISSUE SPECIFICITY.
[14]	"Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint." Campaner S., Kaldis P., Izraeli S., Kirsch I.R. Mol. Cell. Biol. 25:6660-6672(2005) [PubMed: 16024801] [Abstract] Cited for: FUNCTION, PHOSPHORYLATION.
[15]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1004, MASS SPECTROMETRY. Tissue: Epithelium.
[16]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-753, MASS SPECTROMETRY.
[17]	"Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly." Kumar A., Girimaji S.C., Duvvari M.R., Blanton S.H. Am. J. Hum. Genet. 84:286-290(2009) [PubMed: 19215732] [Abstract] Cited for: INVOLVEMENT IN MCPH7.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases
EMBLGenBankDDBJ	M74558 mRNA. Translation: AAA60550.1. AF349657 , AF349642, AF349643, AF349645, AF349647, AF349649, AF349651, AF349653, AF349656, AF349655, AF349654, AF349652, AF349650, AF349648, AF349646, AF349644 Genomic DNA. Translation: AAK51418.1. CR749851 mRNA. Translation: CAH18699.1. AL513322, AL135960 Genomic DNA. Translation: CAI13468.1. AL135960, AL513322 Genomic DNA. Translation: CAI19733.1. BC126223 mRNA. Translation: AAI26224.1.
IPI	IPI00328131. IPI00745920.
PIR	A41685.
RefSeq	NP_001041631.1. NP_003026.2.
UniGene	Hs.525198
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q15468.
Proteomic databases
PRIDE	Q15468.
Genome annotation databases
Ensembl	ENSG00000123473. Homo sapiens. [Contig view]
GeneID	6491.
KEGG	hsa:6491.
Organism-specific databases
GeneCards	GC01M047488.
HGNC	HGNC:10879. STIL.
MIM	181590. gene. 612703. phenotype.
Orphanet	513. Leukemia, lymphoblastic, acute. 2512. Microcephaly, isolated congenital.
PharmGKB	PA35780.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q15468.
OMA	Q15468. TLKQMNS.
Enzyme and pathway databases
Pathway_Interaction_DB	hedgehog_2pathway. Signaling events mediated by the Hedgehog family.
Gene expression databases
ArrayExpress	Q15468.
Bgee	Q15468.
CleanEx	HS_STIL.
Family and domain databases
ProtoNet	Search...
Other Resources
NextBio	25225.
SOURCE	Search...

Entry information

Entry name

STIL_HUMAN

Accession

Primary (citable) accession number: Q15468
Secondary accession number(s): Q5T0C5, Q68CN9

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 9, 2007
Last sequence update:	January 9, 2007
Last modified:	June 16, 2009
This is version 51 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)