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Q15468

- STIL_HUMAN

UniProt

Q15468 - STIL_HUMAN

Protein

SCL-interrupting locus protein

Gene

STIL

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (09 Jan 2007)
      Previous versions | rss
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    Functioni

    Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1.2 Publications

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. cell proliferation Source: ProtInc
    2. determination of left/right symmetry Source: BHF-UCL
    3. embryonic axis specification Source: BHF-UCL
    4. floor plate development Source: BHF-UCL
    5. forebrain development Source: BHF-UCL
    6. heart looping Source: BHF-UCL
    7. in utero embryonic development Source: BHF-UCL
    8. multicellular organism growth Source: BHF-UCL
    9. negative regulation of apoptotic process Source: BHF-UCL
    10. neural tube closure Source: BHF-UCL
    11. neural tube development Source: BHF-UCL
    12. notochord development Source: BHF-UCL
    13. smoothened signaling pathway Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    SCL-interrupting locus protein
    Alternative name(s):
    TAL-1-interrupting locus protein
    Gene namesi
    Name:STIL
    Synonyms:SIL
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10879. STIL.

    Subcellular locationi

    Cytoplasmcytosol By similarity

    GO - Cellular componenti

    1. centrosome Source: UniProtKB
    2. cytosol Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving STIL may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). A deletion at 1p32 between STIL and TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to TAL1 exon 3. As both STIL exon 1 and TAL1 exon 3 are 5'-untranslated exons, STIL/TAL1 fusion mRNA predicts a full length TAL1 protein under the control of the STIL promoter, leading to inappropriate TAL1 expression. In childhood T-cell malignancies (T-ALL), a type of defect such as STIL/TAL1 fusion is associated with a good prognosis. In cultured lymphocytes from healthy adults, STIL/TAL1 fusion mRNA may be detected after 7 days of culture.
    Microcephaly 7, primary, autosomal recessive (MCPH7) [MIM:612703]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.

    Keywords - Diseasei

    Mental retardation, Primary microcephaly, Proto-oncogene

    Organism-specific databases

    MIMi612703. phenotype.
    Orphaneti2512. Autosomal recessive primary microcephaly.
    99861. Precursor T-cell acute lymphoblastic leukemia.
    PharmGKBiPA35780.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12871287SCL-interrupting locus proteinPRO_0000271332Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei753 – 7531Phosphoserine2 Publications
    Modified residuei1135 – 11351Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated following the activation of the mitotic checkpoint.3 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ15468.
    PaxDbiQ15468.
    PRIDEiQ15468.

    PTM databases

    PhosphoSiteiQ15468.

    Expressioni

    Tissue specificityi

    Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer.2 Publications

    Inductioni

    Down-regulated when cell proliferation ceased. Accumulates during G2 phase and falls at completion of the cell cycle.1 Publication

    Gene expression databases

    ArrayExpressiQ15468.
    BgeeiQ15468.
    CleanExiHS_STIL.
    GenevestigatoriQ15468.

    Interactioni

    Subunit structurei

    Interacts with PIN1 via its WW domain. This interaction is dependent on STIL mitotic phosphorylation By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CENPJQ9HC7712EBI-7488405,EBI-946194
    SASS6Q6UVJ03EBI-7488405,EBI-1570153

    Protein-protein interaction databases

    BioGridi112382. 1 interaction.
    DIPiDIP-60580N.
    IntActiQ15468. 2 interactions.
    MINTiMINT-8340696.
    STRINGi9606.ENSP00000360944.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15468.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni584 – 779196PIN1-bindingBy similarityAdd
    BLAST

    Phylogenomic databases

    eggNOGiNOG39781.
    HOGENOMiHOG000231284.
    HOVERGENiHBG079548.
    KOiK16724.
    OMAiLISPNNM.
    OrthoDBiEOG7Z69BH.
    PhylomeDBiQ15468.
    TreeFamiTF331178.

    Family and domain databases

    InterProiIPR026123. Sil.
    [Graphical view]
    PANTHERiPTHR15128. PTHR15128. 1 hit.
    PfamiPF15253. STIL_N. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15468-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY     50
    RNPKLVVTEK TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF 100
    DPGREVPECL EITPTASLPG DFLIPCKVHT QELCSREMIV HSVDDFSSAL 150
    KALQCHICSK DSLDCGKLLS LRVHITSRES LDSVEFDLHW AAVTLANNFK 200
    CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE TRKLLLLLES 250
    DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 300
    IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP 350
    IRCELSAESQ NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE 400
    DFSPRPIPSP HPVSQKISKI QPSVPELSLV LDGNFIESNP LPTPLEMVNN 450
    ENPPLINHLE HLKPLQPQLY DEKHSPEVEA GEPSLRGIPN QLNQDKPALL 500
    RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT VSAGNVQNEE 550
    YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 600
    NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA 650
    LYCNAFCSSS SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC 700
    TVCMHTPKTE SDNGMMGLSP DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM 750
    PCSPKTTAVE DTVQAGRQME LVSVEAQSSP GLHMRKGVSI AVSTGASLFW 800
    NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG SASSLKAVDI 850
    PSFEESNIAV EEEFNQPLSV SNSSLVVRKE PDVPVFFPSG QLAESVSMCL 900
    QTGPTGGASN NSETSEEPKI EHVMQPLLHQ PSDNQKIYQD LLGQVNHLLN 950
    SSSKETEQPS TKAVIISHEC TRTQNVYHTK KKTHHSRLVD KDCVLNATLK 1000
    QLRSLGVKID SPTKVKKNAH NVDHASVLAC ISPEAVISGL NCMSFANVGM 1050
    SGLSPNGVDL SMEANAIALK YLNENQLSQL SVTRSNQNNC DPFSLLHINT 1100
    DRSTVGLSLI SPNNMSFATK KYMKRYGLLQ SSDNSEDEEE PPDNADSKSE 1150
    YLLNQNLRSI PEQLGGQKEP SKNDHEIINC SNCESVGTNA DTPVLRNITN 1200
    EVLQTKAKQQ LTEKPAFLVK NLKPSPAVNL RTGKAEFTQH PEKENEGDIT 1250
    IFPESLQPSE TLKQMNSMNS VGTFLDVKRL RQLPKLF 1287
    Length:1,287
    Mass (Da):142,955
    Last modified:January 9, 2007 - v2
    Checksum:i7F15BEDA8717659C
    GO
    Isoform 2 (identifier: Q15468-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         872-872: N → NS

    Note: No experimental confirmation available.

    Show »
    Length:1,288
    Mass (Da):143,042
    Checksum:i56143155E2FBA492
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti70 – 712KQ → NE in AAA60550. (PubMed:1922059)Curated
    Sequence conflicti70 – 712KQ → NE in AAK51418. (PubMed:12438740)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti86 – 861A → V.2 Publications
    Corresponds to variant rs3125630 [ dbSNP | Ensembl ].
    VAR_029870
    Natural varianti984 – 9841H → R.1 Publication
    Corresponds to variant rs13376679 [ dbSNP | Ensembl ].
    VAR_029871
    Natural varianti1012 – 10121P → R.1 Publication
    VAR_029872
    Natural varianti1145 – 11451A → V.
    Corresponds to variant rs3766317 [ dbSNP | Ensembl ].
    VAR_051386

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei872 – 8721N → NS in isoform 2. 1 PublicationVSP_022301

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74558 mRNA. Translation: AAA60550.1.
    AF349657
    , AF349642, AF349643, AF349645, AF349647, AF349649, AF349651, AF349653, AF349656, AF349655, AF349654, AF349652, AF349650, AF349648, AF349646, AF349644 Genomic DNA. Translation: AAK51418.1.
    CR749851 mRNA. Translation: CAH18699.1.
    AL513322, AL135960 Genomic DNA. Translation: CAI13468.1.
    AL135960, AL513322 Genomic DNA. Translation: CAI19733.1.
    BC126223 mRNA. Translation: AAI26224.1.
    CCDSiCCDS41329.1. [Q15468-2]
    CCDS548.1. [Q15468-1]
    PIRiA41685.
    RefSeqiNP_001041631.1. NM_001048166.1. [Q15468-2]
    NP_001269865.1. NM_001282936.1. [Q15468-1]
    NP_001269866.1. NM_001282937.1.
    NP_001269867.1. NM_001282938.1.
    NP_001269868.1. NM_001282939.1.
    NP_003026.2. NM_003035.2. [Q15468-1]
    XP_006710897.1. XM_006710834.1. [Q15468-2]
    UniGeneiHs.525198.

    Genome annotation databases

    EnsembliENST00000337817; ENSP00000337367; ENSG00000123473. [Q15468-1]
    ENST00000360380; ENSP00000353544; ENSG00000123473. [Q15468-1]
    ENST00000371877; ENSP00000360944; ENSG00000123473. [Q15468-2]
    GeneIDi6491.
    KEGGihsa:6491.
    UCSCiuc001crc.1. human. [Q15468-1]
    uc001crd.1. human. [Q15468-2]

    Polymorphism databases

    DMDMi122070597.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M74558 mRNA. Translation: AAA60550.1 .
    AF349657
    , AF349642 , AF349643 , AF349645 , AF349647 , AF349649 , AF349651 , AF349653 , AF349656 , AF349655 , AF349654 , AF349652 , AF349650 , AF349648 , AF349646 , AF349644 Genomic DNA. Translation: AAK51418.1 .
    CR749851 mRNA. Translation: CAH18699.1 .
    AL513322 , AL135960 Genomic DNA. Translation: CAI13468.1 .
    AL135960 , AL513322 Genomic DNA. Translation: CAI19733.1 .
    BC126223 mRNA. Translation: AAI26224.1 .
    CCDSi CCDS41329.1. [Q15468-2 ]
    CCDS548.1. [Q15468-1 ]
    PIRi A41685.
    RefSeqi NP_001041631.1. NM_001048166.1. [Q15468-2 ]
    NP_001269865.1. NM_001282936.1. [Q15468-1 ]
    NP_001269866.1. NM_001282937.1.
    NP_001269867.1. NM_001282938.1.
    NP_001269868.1. NM_001282939.1.
    NP_003026.2. NM_003035.2. [Q15468-1 ]
    XP_006710897.1. XM_006710834.1. [Q15468-2 ]
    UniGenei Hs.525198.

    3D structure databases

    ProteinModelPortali Q15468.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112382. 1 interaction.
    DIPi DIP-60580N.
    IntActi Q15468. 2 interactions.
    MINTi MINT-8340696.
    STRINGi 9606.ENSP00000360944.

    PTM databases

    PhosphoSitei Q15468.

    Polymorphism databases

    DMDMi 122070597.

    Proteomic databases

    MaxQBi Q15468.
    PaxDbi Q15468.
    PRIDEi Q15468.

    Protocols and materials databases

    DNASUi 6491.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000337817 ; ENSP00000337367 ; ENSG00000123473 . [Q15468-1 ]
    ENST00000360380 ; ENSP00000353544 ; ENSG00000123473 . [Q15468-1 ]
    ENST00000371877 ; ENSP00000360944 ; ENSG00000123473 . [Q15468-2 ]
    GeneIDi 6491.
    KEGGi hsa:6491.
    UCSCi uc001crc.1. human. [Q15468-1 ]
    uc001crd.1. human. [Q15468-2 ]

    Organism-specific databases

    CTDi 6491.
    GeneCardsi GC01M047715.
    GeneReviewsi STIL.
    HGNCi HGNC:10879. STIL.
    MIMi 181590. gene.
    612703. phenotype.
    neXtProti NX_Q15468.
    Orphaneti 2512. Autosomal recessive primary microcephaly.
    99861. Precursor T-cell acute lymphoblastic leukemia.
    PharmGKBi PA35780.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG39781.
    HOGENOMi HOG000231284.
    HOVERGENi HBG079548.
    KOi K16724.
    OMAi LISPNNM.
    OrthoDBi EOG7Z69BH.
    PhylomeDBi Q15468.
    TreeFami TF331178.

    Miscellaneous databases

    GeneWikii STIL.
    GenomeRNAii 6491.
    NextBioi 25225.
    PROi Q15468.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15468.
    Bgeei Q15468.
    CleanExi HS_STIL.
    Genevestigatori Q15468.

    Family and domain databases

    InterProi IPR026123. Sil.
    [Graphical view ]
    PANTHERi PTHR15128. PTHR15128. 1 hit.
    Pfami PF15253. STIL_N. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia."
      Aplan P.D., Lombardi D.P., Kirsch I.R.
      Mol. Cell. Biol. 11:5462-5469(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL REARRANGEMENT, TISSUE SPECIFICITY.
      Tissue: Bone marrow.
    2. "The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly."
      Karkera J.D., Izraeli S., Roessler E., Dutra A., Kirsch I.R., Muenke M.
      Cytogenet. Genome Res. 97:62-67(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), VARIANTS VAL-86 AND ARG-1012.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS VAL-86 AND ARG-984.
      Tissue: Uterus.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia."
      Brown L., Cheng J.-T., Chen Q., Siciliano M.J., Crist W., Buchanan G., Baer R.
      EMBO J. 9:3343-3351(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL REARRANGEMENT.
    7. "Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity."
      Aplan P.D., Lombardi D.P., Ginsberg A.M., Cossman J., Bertness V.L., Kirsch I.R.
      Science 250:1426-1429(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL REARRANGEMENT.
    8. "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia."
      Aplan P.D., Lombardi D.P., Reaman G.H., Sather H.N., Hammond G.D., Kirsch I.R.
      Blood 79:1327-1333(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL REARRANGEMENT.
    9. "Expression of the SIL gene is correlated with growth induction and cellular proliferation."
      Izraeli S., Colaizzo-Anas T., Bertness V.L., Mani K., Aplan P.D., Kirsch I.R.
      Cell Growth Differ. 8:1171-1179(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    10. "Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints."
      Raghavan S.C., Kirsch I.R., Lieber M.R.
      J. Biol. Chem. 276:29126-29133(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL REARRANGEMENT.
    11. "Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR."
      Curry J.D., Smith M.T.
      Leuk. Res. 27:575-582(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL REARRANGEMENT.
    12. "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951."
      Cave H., Suciu S., Preudhomme C., Poppe B., Robert A., Uyttebroeck A., Malet M., Boutard P., Benoit Y., Mauvieux L., Lutz P., Mechinaud F., Grardel N., Mazingue F., Dupont M., Margueritte G., Pages M.-P., Bertrand Y.
      , Plouvier E., Brunie G., Bastard C., Plantaz D., Vande Velde I., Hagemeijer A., Speleman F., Lessard M., Otten J., Vilmer E., Dastugue N.
      Blood 103:442-450(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHROMOSOMAL REARRANGEMENT.
    13. Cited for: TISSUE SPECIFICITY.
    14. "Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint."
      Campaner S., Kaldis P., Izraeli S., Kirsch I.R.
      Mol. Cell. Biol. 25:6660-6672(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, PHOSPHORYLATION.
    15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-753, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. "Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly."
      Kumar A., Girimaji S.C., Duvvari M.R., Blanton S.H.
      Am. J. Hum. Genet. 84:286-290(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN MCPH7.
    17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    18. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiSTIL_HUMAN
    AccessioniPrimary (citable) accession number: Q15468
    Secondary accession number(s): Q5T0C5, Q68CN9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: January 9, 2007
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3