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Q15468 (STIL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 98. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
SCL-interrupting locus protein
Alternative name(s):
TAL-1-interrupting locus protein
Gene names
Name:STIL
Synonyms:SIL
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1287 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. Ref.9 Ref.14

Subunit structure

Interacts with PIN1 via its WW domain. This interaction is dependent on STIL mitotic phosphorylation By similarity.

Subcellular location

Cytoplasmcytosol By similarity.

Tissue specificity

Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer. Ref.1 Ref.13

Induction

Down-regulated when cell proliferation ceased. Accumulates during G2 phase and falls at completion of the cell cycle. Ref.9

Post-translational modification

Phosphorylated following the activation of the mitotic checkpoint. Ref.14

Involvement in disease

A chromosomal aberration involving STIL may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). A deletion at 1p32 between STIL and TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to TAL1 exon 3. As both STIL exon 1 and TAL1 exon 3 are 5'-untranslated exons, STIL/TAL1 fusion mRNA predicts a full length TAL1 protein under the control of the STIL promoter, leading to inappropriate TAL1 expression. In childhood T-cell malignancies (T-ALL), a type of defect such as STIL/TAL1 fusion is associated with a good prognosis. In cultured lymphocytes from healthy adults, STIL/TAL1 fusion mRNA may be detected after 7 days of culture.

Microcephaly 7, primary, autosomal recessive (MCPH7) [MIM:612703]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.16

Ontologies

Keywords
   Cellular componentCytoplasm
   Coding sequence diversityAlternative splicing
Chromosomal rearrangement
Polymorphism
   DiseaseMental retardation
Primary microcephaly
Proto-oncogene
   Molecular functionDevelopmental protein
   PTMAcetylation
Phosphoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processcell proliferation

Traceable author statement PubMed 8825637. Source: ProtInc

determination of left/right symmetry

Inferred from sequence or structural similarity. Source: BHF-UCL

embryonic axis specification

Inferred from sequence or structural similarity. Source: BHF-UCL

floor plate development

Inferred from sequence or structural similarity. Source: BHF-UCL

forebrain development

Inferred from sequence or structural similarity. Source: BHF-UCL

heart looping

Inferred from sequence or structural similarity. Source: BHF-UCL

in utero embryonic development

Inferred from sequence or structural similarity. Source: BHF-UCL

multicellular organism growth

Inferred from sequence or structural similarity. Source: BHF-UCL

negative regulation of apoptotic process

Inferred from sequence or structural similarity. Source: BHF-UCL

neural tube closure

Inferred from sequence or structural similarity. Source: BHF-UCL

neural tube development

Inferred from sequence or structural similarity. Source: BHF-UCL

notochord development

Inferred from sequence or structural similarity. Source: BHF-UCL

smoothened signaling pathway

Inferred from sequence or structural similarity. Source: BHF-UCL

   Cellular_componentcentrosome

Inferred from direct assay PubMed 21399614. Source: UniProtKB

cytosol

Inferred from electronic annotation. Source: UniProtKB-SubCell

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

CENPJQ9HC7712EBI-7488405,EBI-946194
SASS6Q6UVJ03EBI-7488405,EBI-1570153

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q15468-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q15468-2)

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: N → NS
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 12871287SCL-interrupting locus protein
PRO_0000271332

Regions

Region584 – 779196PIN1-binding By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.18
Modified residue7531Phosphoserine Ref.15
Modified residue11351Phosphoserine Ref.17

Natural variations

Alternative sequence8721N → NS in isoform 2.
VSP_022301
Natural variant861A → V. Ref.2 Ref.3
Corresponds to variant rs3125630 [ dbSNP | Ensembl ].
VAR_029870
Natural variant9841H → R. Ref.3
Corresponds to variant rs13376679 [ dbSNP | Ensembl ].
VAR_029871
Natural variant10121P → R. Ref.2
VAR_029872
Natural variant11451A → V.
Corresponds to variant rs3766317 [ dbSNP | Ensembl ].
VAR_051386

Experimental info

Sequence conflict70 – 712KQ → NE in AAA60550. Ref.1
Sequence conflict70 – 712KQ → NE in AAK51418. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified January 9, 2007. Version 2.
Checksum: 7F15BEDA8717659C

FASTA1,287142,955
        10         20         30         40         50         60 
MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY RNPKLVVTEK 

        70         80         90        100        110        120 
TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF DPGREVPECL EITPTASLPG 

       130        140        150        160        170        180 
DFLIPCKVHT QELCSREMIV HSVDDFSSAL KALQCHICSK DSLDCGKLLS LRVHITSRES 

       190        200        210        220        230        240 
LDSVEFDLHW AAVTLANNFK CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE 

       250        260        270        280        290        300 
TRKLLLLLES DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 

       310        320        330        340        350        360 
IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP IRCELSAESQ 

       370        380        390        400        410        420 
NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE DFSPRPIPSP HPVSQKISKI 

       430        440        450        460        470        480 
QPSVPELSLV LDGNFIESNP LPTPLEMVNN ENPPLINHLE HLKPLQPQLY DEKHSPEVEA 

       490        500        510        520        530        540 
GEPSLRGIPN QLNQDKPALL RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT 

       550        560        570        580        590        600 
VSAGNVQNEE YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 

       610        620        630        640        650        660 
NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA LYCNAFCSSS 

       670        680        690        700        710        720 
SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC TVCMHTPKTE SDNGMMGLSP 

       730        740        750        760        770        780 
DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM PCSPKTTAVE DTVQAGRQME LVSVEAQSSP 

       790        800        810        820        830        840 
GLHMRKGVSI AVSTGASLFW NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG 

       850        860        870        880        890        900 
SASSLKAVDI PSFEESNIAV EEEFNQPLSV SNSSLVVRKE PDVPVFFPSG QLAESVSMCL 

       910        920        930        940        950        960 
QTGPTGGASN NSETSEEPKI EHVMQPLLHQ PSDNQKIYQD LLGQVNHLLN SSSKETEQPS 

       970        980        990       1000       1010       1020 
TKAVIISHEC TRTQNVYHTK KKTHHSRLVD KDCVLNATLK QLRSLGVKID SPTKVKKNAH 

      1030       1040       1050       1060       1070       1080 
NVDHASVLAC ISPEAVISGL NCMSFANVGM SGLSPNGVDL SMEANAIALK YLNENQLSQL 

      1090       1100       1110       1120       1130       1140 
SVTRSNQNNC DPFSLLHINT DRSTVGLSLI SPNNMSFATK KYMKRYGLLQ SSDNSEDEEE 

      1150       1160       1170       1180       1190       1200 
PPDNADSKSE YLLNQNLRSI PEQLGGQKEP SKNDHEIINC SNCESVGTNA DTPVLRNITN 

      1210       1220       1230       1240       1250       1260 
EVLQTKAKQQ LTEKPAFLVK NLKPSPAVNL RTGKAEFTQH PEKENEGDIT IFPESLQPSE 

      1270       1280 
TLKQMNSMNS VGTFLDVKRL RQLPKLF 

« Hide

Isoform 2 [UniParc].

Checksum: 56143155E2FBA492
Show »

FASTA1,288143,042

References

« Hide 'large scale' references
[1]"Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia."
Aplan P.D., Lombardi D.P., Kirsch I.R.
Mol. Cell. Biol. 11:5462-5469(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL REARRANGEMENT, TISSUE SPECIFICITY.
Tissue: Bone marrow.
[2]"The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly."
Karkera J.D., Izraeli S., Roessler E., Dutra A., Kirsch I.R., Muenke M.
Cytogenet. Genome Res. 97:62-67(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), VARIANTS VAL-86 AND ARG-1012.
[3]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS VAL-86 AND ARG-984.
Tissue: Uterus.
[4]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]"Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia."
Brown L., Cheng J.-T., Chen Q., Siciliano M.J., Crist W., Buchanan G., Baer R.
EMBO J. 9:3343-3351(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL REARRANGEMENT.
[7]"Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity."
Aplan P.D., Lombardi D.P., Ginsberg A.M., Cossman J., Bertness V.L., Kirsch I.R.
Science 250:1426-1429(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL REARRANGEMENT.
[8]"Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia."
Aplan P.D., Lombardi D.P., Reaman G.H., Sather H.N., Hammond G.D., Kirsch I.R.
Blood 79:1327-1333(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL REARRANGEMENT.
[9]"Expression of the SIL gene is correlated with growth induction and cellular proliferation."
Izraeli S., Colaizzo-Anas T., Bertness V.L., Mani K., Aplan P.D., Kirsch I.R.
Cell Growth Differ. 8:1171-1179(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, INDUCTION.
[10]"Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints."
Raghavan S.C., Kirsch I.R., Lieber M.R.
J. Biol. Chem. 276:29126-29133(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL REARRANGEMENT.
[11]"Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR."
Curry J.D., Smith M.T.
Leuk. Res. 27:575-582(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL REARRANGEMENT.
[12]"Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951."
Cave H., Suciu S., Preudhomme C., Poppe B., Robert A., Uyttebroeck A., Malet M., Boutard P., Benoit Y., Mauvieux L., Lutz P., Mechinaud F., Grardel N., Mazingue F., Dupont M., Margueritte G., Pages M.-P., Bertrand Y. expand/collapse author list , Plouvier E., Brunie G., Bastard C., Plantaz D., Vande Velde I., Hagemeijer A., Speleman F., Lessard M., Otten J., Vilmer E., Dastugue N.
Blood 103:442-450(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: CHROMOSOMAL REARRANGEMENT.
[13]"Sil overexpression in lung cancer characterizes tumors with increased mitotic activity."
Erez A., Perelman M., Hewitt S.M., Cojacaru G., Goldberg I., Shahar I., Yaron P., Muler I., Campaner S., Amariglio N., Rechavi G., Kirsch I.R., Krupsky M., Kaminski N., Izraeli S.
Oncogene 23:5371-5377(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: TISSUE SPECIFICITY.
[14]"Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint."
Campaner S., Kaldis P., Izraeli S., Kirsch I.R.
Mol. Cell. Biol. 25:6660-6672(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, PHOSPHORYLATION.
[15]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-753, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[16]"Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly."
Kumar A., Girimaji S.C., Duvvari M.R., Blanton S.H.
Am. J. Hum. Genet. 84:286-290(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: INVOLVEMENT IN MCPH7.
[17]"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Leukemic T-cell.
[18]"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P., Lasa M., Polevoda B., Gazquez C., Elosegui-Artola A., Kim D.S., De Juan-Pardo E., Demeyer K., Hole K., Larrea E., Timmerman E., Prieto J., Arnesen T., Sherman F., Gevaert K., Aldabe R.
Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M74558 mRNA. Translation: AAA60550.1.
AF349657 expand/collapse EMBL AC list , AF349642, AF349643, AF349645, AF349647, AF349649, AF349651, AF349653, AF349656, AF349655, AF349654, AF349652, AF349650, AF349648, AF349646, AF349644 Genomic DNA. Translation: AAK51418.1.
CR749851 mRNA. Translation: CAH18699.1.
AL513322, AL135960 Genomic DNA. Translation: CAI13468.1.
AL135960, AL513322 Genomic DNA. Translation: CAI19733.1.
BC126223 mRNA. Translation: AAI26224.1.
PIRA41685.
RefSeqNP_001041631.1. NM_001048166.1.
NP_001269865.1. NM_001282936.1.
NP_001269866.1. NM_001282937.1.
NP_001269867.1. NM_001282938.1.
NP_001269868.1. NM_001282939.1.
NP_003026.2. NM_003035.2.
UniGeneHs.525198.

3D structure databases

ProteinModelPortalQ15468.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112382. 1 interaction.
DIPDIP-60580N.
IntActQ15468. 2 interactions.
MINTMINT-8340696.
STRING9606.ENSP00000360944.

PTM databases

PhosphoSiteQ15468.

Polymorphism databases

DMDM122070597.

Proteomic databases

PaxDbQ15468.
PRIDEQ15468.

Protocols and materials databases

DNASU6491.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000243182; ENSP00000243182; ENSG00000123473. [Q15468-1]
ENST00000337817; ENSP00000337367; ENSG00000123473. [Q15468-1]
ENST00000360380; ENSP00000353544; ENSG00000123473. [Q15468-1]
ENST00000371877; ENSP00000360944; ENSG00000123473. [Q15468-2]
GeneID6491.
KEGGhsa:6491.
UCSCuc001crc.1. human. [Q15468-1]
uc001crd.1. human. [Q15468-2]

Organism-specific databases

CTD6491.
GeneCardsGC01M047715.
HGNCHGNC:10879. STIL.
MIM181590. gene.
612703. phenotype.
neXtProtNX_Q15468.
Orphanet2512. Autosomal recessive primary microcephaly.
99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBPA35780.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG39781.
HOGENOMHOG000231284.
HOVERGENHBG079548.
KOK16724.
OMAACISPEA.
OrthoDBEOG7Z69BH.
PhylomeDBQ15468.
TreeFamTF331178.

Gene expression databases

ArrayExpressQ15468.
BgeeQ15468.
CleanExHS_STIL.
GenevestigatorQ15468.

Family and domain databases

InterProIPR026123. Sil.
[Graphical view]
PANTHERPTHR15128. PTHR15128. 1 hit.
PfamPF15253. STIL_N. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiSTIL.
GenomeRNAi6491.
NextBio25225.
PROQ15468.
SOURCESearch...

Entry information

Entry nameSTIL_HUMAN
AccessionPrimary (citable) accession number: Q15468
Secondary accession number(s): Q5T0C5, Q68CN9
Entry history
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: April 16, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM