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Q15468

- STIL_HUMAN

UniProt

Q15468 - STIL_HUMAN

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Protein
SCL-interrupting locus protein
Gene
STIL, SIL
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Immediate-early gene. Plays an important role in embryonic development as well as in cellular growth and proliferation; its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1.2 Publications

GO - Molecular functioni

  1. protein binding Source: IntAct

GO - Biological processi

  1. cell proliferation Source: ProtInc
  2. determination of left/right symmetry Source: BHF-UCL
  3. embryonic axis specification Source: BHF-UCL
  4. floor plate development Source: BHF-UCL
  5. forebrain development Source: BHF-UCL
  6. heart looping Source: BHF-UCL
  7. in utero embryonic development Source: BHF-UCL
  8. multicellular organism growth Source: BHF-UCL
  9. negative regulation of apoptotic process Source: BHF-UCL
  10. neural tube closure Source: BHF-UCL
  11. neural tube development Source: BHF-UCL
  12. notochord development Source: BHF-UCL
  13. smoothened signaling pathway Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Names & Taxonomyi

Protein namesi
Recommended name:
SCL-interrupting locus protein
Alternative name(s):
TAL-1-interrupting locus protein
Gene namesi
Name:STIL
Synonyms:SIL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10879. STIL.

Subcellular locationi

Cytoplasmcytosol By similarity

GO - Cellular componenti

  1. centrosome Source: UniProtKB
  2. cytosol Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving STIL may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). A deletion at 1p32 between STIL and TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to TAL1 exon 3. As both STIL exon 1 and TAL1 exon 3 are 5'-untranslated exons, STIL/TAL1 fusion mRNA predicts a full length TAL1 protein under the control of the STIL promoter, leading to inappropriate TAL1 expression. In childhood T-cell malignancies (T-ALL), a type of defect such as STIL/TAL1 fusion is associated with a good prognosis. In cultured lymphocytes from healthy adults, STIL/TAL1 fusion mRNA may be detected after 7 days of culture.
Microcephaly 7, primary, autosomal recessive (MCPH7) [MIM:612703]: A disease defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Affected individuals are mentally retarded. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits due to degenerative brain disorder.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication

Keywords - Diseasei

Mental retardation, Primary microcephaly, Proto-oncogene

Organism-specific databases

MIMi612703. phenotype.
Orphaneti2512. Autosomal recessive primary microcephaly.
99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA35780.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 12871287SCL-interrupting locus protein
PRO_0000271332Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei753 – 7531Phosphoserine1 Publication
Modified residuei1135 – 11351Phosphoserine1 Publication

Post-translational modificationi

Phosphorylated following the activation of the mitotic checkpoint.1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ15468.
PaxDbiQ15468.
PRIDEiQ15468.

PTM databases

PhosphoSiteiQ15468.

Expressioni

Tissue specificityi

Expressed in all hematopoietic tissues and cell lines. Highly expressed in a variety of tumors characterized by increased mitotic activity with highest expression in lung cancer.2 Publications

Inductioni

Down-regulated when cell proliferation ceased. Accumulates during G2 phase and falls at completion of the cell cycle.1 Publication

Gene expression databases

ArrayExpressiQ15468.
BgeeiQ15468.
CleanExiHS_STIL.
GenevestigatoriQ15468.

Interactioni

Subunit structurei

Interacts with PIN1 via its WW domain. This interaction is dependent on STIL mitotic phosphorylation By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
CENPJQ9HC7712EBI-7488405,EBI-946194
SASS6Q6UVJ03EBI-7488405,EBI-1570153

Protein-protein interaction databases

BioGridi112382. 1 interaction.
DIPiDIP-60580N.
IntActiQ15468. 2 interactions.
MINTiMINT-8340696.
STRINGi9606.ENSP00000360944.

Structurei

3D structure databases

ProteinModelPortaliQ15468.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni584 – 779196PIN1-binding By similarity
Add
BLAST

Phylogenomic databases

eggNOGiNOG39781.
HOGENOMiHOG000231284.
HOVERGENiHBG079548.
KOiK16724.
OMAiLISPNNM.
OrthoDBiEOG7Z69BH.
PhylomeDBiQ15468.
TreeFamiTF331178.

Family and domain databases

InterProiIPR026123. Sil.
[Graphical view]
PANTHERiPTHR15128. PTHR15128. 1 hit.
PfamiPF15253. STIL_N. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15468-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MEPIYPFARP QMNTRFPSSR MVPFHFPPSK CALWNPTPTG DFIYLHLSYY     50
RNPKLVVTEK TIRLAYRHAK QNKKNSSCFL LGSLTADEDE EGVTLTVDRF 100
DPGREVPECL EITPTASLPG DFLIPCKVHT QELCSREMIV HSVDDFSSAL 150
KALQCHICSK DSLDCGKLLS LRVHITSRES LDSVEFDLHW AAVTLANNFK 200
CTPVKPIPII PTALARNLSS NLNISQVQGT YKYGYLTMDE TRKLLLLLES 250
DPKVYSLPLV GIWLSGITHI YSPQVWACCL RYIFNSSVQE RVFSESGNFI 300
IVLYSMTHKE PEFYECFPCD GKIPDFRFQL LTSKETLHLF KNVEPPDKNP 350
IRCELSAESQ NAETEFFSKA SKNFSIKRSS QKLSSGKMPI HDHDSGVEDE 400
DFSPRPIPSP HPVSQKISKI QPSVPELSLV LDGNFIESNP LPTPLEMVNN 450
ENPPLINHLE HLKPLQPQLY DEKHSPEVEA GEPSLRGIPN QLNQDKPALL 500
RHCKVRQPPA YKKGNPHTRN SIKPSSHNGP SHDIFEKLQT VSAGNVQNEE 550
YPIRPSTLNS RQSSLAPQSQ PHDFVFSPHN SGRPMELQIP TPPLPSYCST 600
NVCRCCQHHS HIQYSPLNSW QGANTVGSIQ DVQSEALQKH SLFHPSGCPA 650
LYCNAFCSSS SPIALRPQGD MGSCSPHSNI EPSPVARPPS HMDLCNPQPC 700
TVCMHTPKTE SDNGMMGLSP DAYRFLTEQD RQLRLLQAQI QRLLEAQSLM 750
PCSPKTTAVE DTVQAGRQME LVSVEAQSSP GLHMRKGVSI AVSTGASLFW 800
NAAGEDQEPD SQMKQDDTKI SSEDMNFSVD INNEVTSLPG SASSLKAVDI 850
PSFEESNIAV EEEFNQPLSV SNSSLVVRKE PDVPVFFPSG QLAESVSMCL 900
QTGPTGGASN NSETSEEPKI EHVMQPLLHQ PSDNQKIYQD LLGQVNHLLN 950
SSSKETEQPS TKAVIISHEC TRTQNVYHTK KKTHHSRLVD KDCVLNATLK 1000
QLRSLGVKID SPTKVKKNAH NVDHASVLAC ISPEAVISGL NCMSFANVGM 1050
SGLSPNGVDL SMEANAIALK YLNENQLSQL SVTRSNQNNC DPFSLLHINT 1100
DRSTVGLSLI SPNNMSFATK KYMKRYGLLQ SSDNSEDEEE PPDNADSKSE 1150
YLLNQNLRSI PEQLGGQKEP SKNDHEIINC SNCESVGTNA DTPVLRNITN 1200
EVLQTKAKQQ LTEKPAFLVK NLKPSPAVNL RTGKAEFTQH PEKENEGDIT 1250
IFPESLQPSE TLKQMNSMNS VGTFLDVKRL RQLPKLF 1287
Length:1,287
Mass (Da):142,955
Last modified:January 9, 2007 - v2
Checksum:i7F15BEDA8717659C
GO
Isoform 2 (identifier: Q15468-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     872-872: N → NS

Note: No experimental confirmation available.

Show »
Length:1,288
Mass (Da):143,042
Checksum:i56143155E2FBA492
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti86 – 861A → V.2 Publications
Corresponds to variant rs3125630 [ dbSNP | Ensembl ].
VAR_029870
Natural varianti984 – 9841H → R.1 Publication
Corresponds to variant rs13376679 [ dbSNP | Ensembl ].
VAR_029871
Natural varianti1012 – 10121P → R.1 Publication
VAR_029872
Natural varianti1145 – 11451A → V.
Corresponds to variant rs3766317 [ dbSNP | Ensembl ].
VAR_051386

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei872 – 8721N → NS in isoform 2.
VSP_022301

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti70 – 712KQ → NE in AAA60550. 1 Publication
Sequence conflicti70 – 712KQ → NE in AAK51418. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74558 mRNA. Translation: AAA60550.1.
AF349657
, AF349642, AF349643, AF349645, AF349647, AF349649, AF349651, AF349653, AF349656, AF349655, AF349654, AF349652, AF349650, AF349648, AF349646, AF349644 Genomic DNA. Translation: AAK51418.1.
CR749851 mRNA. Translation: CAH18699.1.
AL513322, AL135960 Genomic DNA. Translation: CAI13468.1.
AL135960, AL513322 Genomic DNA. Translation: CAI19733.1.
BC126223 mRNA. Translation: AAI26224.1.
CCDSiCCDS41329.1. [Q15468-2]
CCDS548.1. [Q15468-1]
PIRiA41685.
RefSeqiNP_001041631.1. NM_001048166.1. [Q15468-2]
NP_001269865.1. NM_001282936.1. [Q15468-1]
NP_001269866.1. NM_001282937.1.
NP_001269867.1. NM_001282938.1.
NP_001269868.1. NM_001282939.1.
NP_003026.2. NM_003035.2. [Q15468-1]
XP_006710897.1. XM_006710834.1. [Q15468-2]
UniGeneiHs.525198.

Genome annotation databases

EnsembliENST00000243182; ENSP00000243182; ENSG00000123473. [Q15468-1]
ENST00000337817; ENSP00000337367; ENSG00000123473. [Q15468-1]
ENST00000360380; ENSP00000353544; ENSG00000123473. [Q15468-1]
ENST00000371877; ENSP00000360944; ENSG00000123473. [Q15468-2]
GeneIDi6491.
KEGGihsa:6491.
UCSCiuc001crc.1. human. [Q15468-1]
uc001crd.1. human. [Q15468-2]

Polymorphism databases

DMDMi122070597.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M74558 mRNA. Translation: AAA60550.1 .
AF349657
, AF349642 , AF349643 , AF349645 , AF349647 , AF349649 , AF349651 , AF349653 , AF349656 , AF349655 , AF349654 , AF349652 , AF349650 , AF349648 , AF349646 , AF349644 Genomic DNA. Translation: AAK51418.1 .
CR749851 mRNA. Translation: CAH18699.1 .
AL513322 , AL135960 Genomic DNA. Translation: CAI13468.1 .
AL135960 , AL513322 Genomic DNA. Translation: CAI19733.1 .
BC126223 mRNA. Translation: AAI26224.1 .
CCDSi CCDS41329.1. [Q15468-2 ]
CCDS548.1. [Q15468-1 ]
PIRi A41685.
RefSeqi NP_001041631.1. NM_001048166.1. [Q15468-2 ]
NP_001269865.1. NM_001282936.1. [Q15468-1 ]
NP_001269866.1. NM_001282937.1.
NP_001269867.1. NM_001282938.1.
NP_001269868.1. NM_001282939.1.
NP_003026.2. NM_003035.2. [Q15468-1 ]
XP_006710897.1. XM_006710834.1. [Q15468-2 ]
UniGenei Hs.525198.

3D structure databases

ProteinModelPortali Q15468.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112382. 1 interaction.
DIPi DIP-60580N.
IntActi Q15468. 2 interactions.
MINTi MINT-8340696.
STRINGi 9606.ENSP00000360944.

PTM databases

PhosphoSitei Q15468.

Polymorphism databases

DMDMi 122070597.

Proteomic databases

MaxQBi Q15468.
PaxDbi Q15468.
PRIDEi Q15468.

Protocols and materials databases

DNASUi 6491.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000243182 ; ENSP00000243182 ; ENSG00000123473 . [Q15468-1 ]
ENST00000337817 ; ENSP00000337367 ; ENSG00000123473 . [Q15468-1 ]
ENST00000360380 ; ENSP00000353544 ; ENSG00000123473 . [Q15468-1 ]
ENST00000371877 ; ENSP00000360944 ; ENSG00000123473 . [Q15468-2 ]
GeneIDi 6491.
KEGGi hsa:6491.
UCSCi uc001crc.1. human. [Q15468-1 ]
uc001crd.1. human. [Q15468-2 ]

Organism-specific databases

CTDi 6491.
GeneCardsi GC01M047715.
GeneReviewsi STIL.
HGNCi HGNC:10879. STIL.
MIMi 181590. gene.
612703. phenotype.
neXtProti NX_Q15468.
Orphaneti 2512. Autosomal recessive primary microcephaly.
99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBi PA35780.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG39781.
HOGENOMi HOG000231284.
HOVERGENi HBG079548.
KOi K16724.
OMAi LISPNNM.
OrthoDBi EOG7Z69BH.
PhylomeDBi Q15468.
TreeFami TF331178.

Miscellaneous databases

GeneWikii STIL.
GenomeRNAii 6491.
NextBioi 25225.
PROi Q15468.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15468.
Bgeei Q15468.
CleanExi HS_STIL.
Genevestigatori Q15468.

Family and domain databases

InterProi IPR026123. Sil.
[Graphical view ]
PANTHERi PTHR15128. PTHR15128. 1 hit.
Pfami PF15253. STIL_N. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structural characterization of SIL, a gene frequently disrupted in T-cell acute lymphoblastic leukemia."
    Aplan P.D., Lombardi D.P., Kirsch I.R.
    Mol. Cell. Biol. 11:5462-5469(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), CHROMOSOMAL REARRANGEMENT, TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  2. "The genomic structure, chromosomal localization, and analysis of SIL as a candidate gene for holoprosencephaly."
    Karkera J.D., Izraeli S., Roessler E., Dutra A., Kirsch I.R., Muenke M.
    Cytogenet. Genome Res. 97:62-67(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORM 1), VARIANTS VAL-86 AND ARG-1012.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANTS VAL-86 AND ARG-984.
    Tissue: Uterus.
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Site-specific recombination of the tal-1 gene is a common occurrence in human T cell leukemia."
    Brown L., Cheng J.-T., Chen Q., Siciliano M.J., Crist W., Buchanan G., Baer R.
    EMBO J. 9:3343-3351(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL REARRANGEMENT.
  7. "Disruption of the human SCL locus by 'illegitimate' V-(D)-J recombinase activity."
    Aplan P.D., Lombardi D.P., Ginsberg A.M., Cossman J., Bertness V.L., Kirsch I.R.
    Science 250:1426-1429(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL REARRANGEMENT.
  8. "Involvement of the putative hematopoietic transcription factor SCL in T-cell acute lymphoblastic leukemia."
    Aplan P.D., Lombardi D.P., Reaman G.H., Sather H.N., Hammond G.D., Kirsch I.R.
    Blood 79:1327-1333(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL REARRANGEMENT.
  9. "Expression of the SIL gene is correlated with growth induction and cellular proliferation."
    Izraeli S., Colaizzo-Anas T., Bertness V.L., Mani K., Aplan P.D., Kirsch I.R.
    Cell Growth Differ. 8:1171-1179(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  10. "Analysis of the V(D)J recombination efficiency at lymphoid chromosomal translocation breakpoints."
    Raghavan S.C., Kirsch I.R., Lieber M.R.
    J. Biol. Chem. 276:29126-29133(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL REARRANGEMENT.
  11. "Measurement of SIL-TAL1 fusion gene transcripts associated with human T-cell lymphocytic leukemia by real-time reverse transcriptase-PCR."
    Curry J.D., Smith M.T.
    Leuk. Res. 27:575-582(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL REARRANGEMENT.
  12. "Clinical significance of HOX11L2 expression linked to t(5;14)(q35;q32), of HOX11 expression, and of SIL-TAL fusion in childhood T-cell malignancies: results of EORTC studies 58881 and 58951."
    Cave H., Suciu S., Preudhomme C., Poppe B., Robert A., Uyttebroeck A., Malet M., Boutard P., Benoit Y., Mauvieux L., Lutz P., Mechinaud F., Grardel N., Mazingue F., Dupont M., Margueritte G., Pages M.-P., Bertrand Y.
    , Plouvier E., Brunie G., Bastard C., Plantaz D., Vande Velde I., Hagemeijer A., Speleman F., Lessard M., Otten J., Vilmer E., Dastugue N.
    Blood 103:442-450(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHROMOSOMAL REARRANGEMENT.
  13. Cited for: TISSUE SPECIFICITY.
  14. "Sil phosphorylation in a Pin1 binding domain affects the duration of the spindle checkpoint."
    Campaner S., Kaldis P., Izraeli S., Kirsch I.R.
    Mol. Cell. Biol. 25:6660-6672(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, PHOSPHORYLATION.
  15. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-753, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  16. "Mutations in STIL, encoding a pericentriolar and centrosomal protein, cause primary microcephaly."
    Kumar A., Girimaji S.C., Duvvari M.R., Blanton S.H.
    Am. J. Hum. Genet. 84:286-290(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN MCPH7.
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1135, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  18. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSTIL_HUMAN
AccessioniPrimary (citable) accession number: Q15468
Secondary accession number(s): Q5T0C5, Q68CN9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: July 9, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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