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Protein

Nuclear receptor subfamily 0 group B member 2

Gene

NR0B2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Acts as a transcriptional regulator. Acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with whom it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1.1 Publication

GO - Molecular functioni

  • DNA binding Source: InterPro
  • protein domain specific binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • steroid hormone receptor activity Source: InterPro
  • transcription corepressor activity Source: UniProtKB
  • transcription factor binding Source: GO_Central

GO - Biological processi

  • animal organ regeneration Source: Ensembl
  • cholesterol metabolic process Source: ProtInc
  • negative regulation of gene expression Source: UniProtKB
  • negative regulation of sequence-specific DNA binding transcription factor activity Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: ProtInc
  • Notch signaling pathway Source: Ensembl
  • positive regulation of gene expression Source: UniProtKB
  • positive regulation of insulin secretion Source: Ensembl
  • response to glucose Source: Ensembl
  • transcription initiation from RNA polymerase II promoter Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor, Repressor

Keywords - Biological processi

Transcription, Transcription regulation

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131910-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiQ15466.
SIGNORiQ15466.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor subfamily 0 group B member 2
Alternative name(s):
Orphan nuclear receptor SHP
Small heterodimer partner
Gene namesi
Name:NR0B2
Synonyms:SHP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:7961. NR0B2.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: Reactome
  • nucleus Source: UniProtKB
  • protein complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

Obesity (OBESITY)1 Publication
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA condition characterized by an increase of body weight beyond the limitation of skeletal and physical requirements, as the result of excessive accumulation of body fat.
See also OMIM:601665

Keywords - Diseasei

Disease mutation, Obesity

Organism-specific databases

DisGeNETi8431.
MalaCardsiNR0B2.
MIMi601665. phenotype.
OpenTargetsiENSG00000131910.
PharmGKBiPA31747.

Chemistry databases

ChEMBLiCHEMBL5603.
GuidetoPHARMACOLOGYi636.

Polymorphism and mutation databases

BioMutaiNR0B2.
DMDMi9978744.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000537521 – 257Nuclear receptor subfamily 0 group B member 2Add BLAST257

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei54Symmetric dimethylarginineBy similarity1
Modified residuei57Symmetric dimethylarginine; by PRMT5By similarity1

Post-translational modificationi

Arginine methylation by PRMT5 enhances repression activity of metabolic genes in liver in response to bile acid signaling, by increasing interaction with cofactors.By similarity

Keywords - PTMi

Methylation

Proteomic databases

PaxDbiQ15466.
PeptideAtlasiQ15466.
PRIDEiQ15466.

PTM databases

iPTMnetiQ15466.
PhosphoSitePlusiQ15466.

Expressioni

Tissue specificityi

Liver. Low levels of expression were detected in heart and pancreas.1 Publication

Gene expression databases

BgeeiENSG00000131910.
CleanExiHS_NR0B2.
GenevisibleiQ15466. HS.

Organism-specific databases

HPAiCAB017032.

Interactioni

Subunit structurei

Interacts with RARA, RXRA, THRB, NR5A1, NR5A2, NR1I3, PPARA, PPARG and EID1. May also interact with HNF4A (By similarity). Heterodimer; efficient DNA binding requires dimerization with another bHLH protein. Interacts (via N-terminus) with NEUROD1 (via N-terminus an C-terminus). Interacts with ID2.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
MDM2Q009874EBI-3910729,EBI-389668
SIRT1Q96EB66EBI-3910729,EBI-1802965
TP53P046373EBI-3910729,EBI-366083

GO - Molecular functioni

  • protein domain specific binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • transcription factor binding Source: GO_Central

Protein-protein interaction databases

BioGridi114012. 60 interactors.
DIPiDIP-46313N.
IntActiQ15466. 18 interactors.
MINTiMINT-8150838.
STRINGi9606.ENSP00000254227.

Structurei

Secondary structure

1257
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi14 – 16Combined sources3
Helixi19 – 26Combined sources8
Helixi118 – 122Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YUCX-ray1.90C/D15-28[»]
2Q3YX-ray2.40B18-27[»]
2Z4JX-ray2.60B115-124[»]
4DORX-ray1.90C/D15-28[»]
4ONIX-ray1.80C/D12-30[»]
ProteinModelPortaliQ15466.
SMRiQ15466.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15466.

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni57 – 228Ligand-bindingBy similarityAdd BLAST172

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00390000015719.
HOGENOMiHOG000231151.
HOVERGENiHBG008136.
InParanoidiQ15466.
KOiK08563.
OMAiSPKEYAY.
OrthoDBiEOG091G0FGK.
PhylomeDBiQ15466.
TreeFamiTF332386.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15466-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTSQPGACP CQGAASRPAI LYALLSSSLK AVPRPRSRCL CRQHRPVQLC
60 70 80 90 100
APHRTCREAL DVLAKTVAFL RNLPSFWQLP PQDQRRLLQG CWGPLFLLGL
110 120 130 140 150
AQDAVTFEVA EAPVPSILKK ILLEEPSSSG GSGQLPDRPQ PSLAAVQWLQ
160 170 180 190 200
CCLESFWSLE LSPKEYACLK GTILFNPDVP GLQAASHIGH LQQEAHWVLC
210 220 230 240 250
EVLEPWCPAA QGRLTRVLLT ASTLKSIPTS LLGDLFFRPI IGDVDIAGLL

GDMLLLR
Length:257
Mass (Da):28,058
Last modified:December 1, 2000 - v2
Checksum:i14BEE2B3FF46154A
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02601557R → W in early-onset obesity; Japanese population; loss of methylation and repressor activity. 2 PublicationsCorresponds to variant rs777291973dbSNPEnsembl.1
Natural variantiVAR_050584171G → A.Corresponds to variant rs6659176dbSNPEnsembl.1
Natural variantiVAR_026016189G → E in early-onset obesity; Japanese population; strong decrease of repressor activity. 1 PublicationCorresponds to variant rs202154574dbSNPEnsembl.1
Natural variantiVAR_026017195A → S in early-onset obesity; Japanese population; slight decrease of repressor activity. 1 PublicationCorresponds to variant rs74315350dbSNPEnsembl.1
Natural variantiVAR_026018213R → C in early-onset obesity; Japanese population; loss of repressor activity. 1 PublicationCorresponds to variant rs199976415dbSNPEnsembl.1
Natural variantiVAR_026019216R → H No effect on repressor activity. 1 PublicationCorresponds to variant rs200475847dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76571 Genomic DNA. Translation: AAC41998.1.
AB058644 Genomic DNA. Translation: BAB68530.1.
HQ692833 mRNA. Translation: ADZ17344.1.
AL356390 Genomic DNA. Translation: CAI13562.1.
CH471059 Genomic DNA. Translation: EAX07781.1.
BC030207 mRNA. Translation: AAH30207.1.
CCDSiCCDS291.1.
RefSeqiNP_068804.1. NM_021969.2.
UniGeneiHs.427055.

Genome annotation databases

EnsembliENST00000254227; ENSP00000254227; ENSG00000131910.
GeneIDi8431.
KEGGihsa:8431.
UCSCiuc001bnf.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L76571 Genomic DNA. Translation: AAC41998.1.
AB058644 Genomic DNA. Translation: BAB68530.1.
HQ692833 mRNA. Translation: ADZ17344.1.
AL356390 Genomic DNA. Translation: CAI13562.1.
CH471059 Genomic DNA. Translation: EAX07781.1.
BC030207 mRNA. Translation: AAH30207.1.
CCDSiCCDS291.1.
RefSeqiNP_068804.1. NM_021969.2.
UniGeneiHs.427055.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1YUCX-ray1.90C/D15-28[»]
2Q3YX-ray2.40B18-27[»]
2Z4JX-ray2.60B115-124[»]
4DORX-ray1.90C/D15-28[»]
4ONIX-ray1.80C/D12-30[»]
ProteinModelPortaliQ15466.
SMRiQ15466.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114012. 60 interactors.
DIPiDIP-46313N.
IntActiQ15466. 18 interactors.
MINTiMINT-8150838.
STRINGi9606.ENSP00000254227.

Chemistry databases

ChEMBLiCHEMBL5603.
GuidetoPHARMACOLOGYi636.

PTM databases

iPTMnetiQ15466.
PhosphoSitePlusiQ15466.

Polymorphism and mutation databases

BioMutaiNR0B2.
DMDMi9978744.

Proteomic databases

PaxDbiQ15466.
PeptideAtlasiQ15466.
PRIDEiQ15466.

Protocols and materials databases

DNASUi8431.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000254227; ENSP00000254227; ENSG00000131910.
GeneIDi8431.
KEGGihsa:8431.
UCSCiuc001bnf.4. human.

Organism-specific databases

CTDi8431.
DisGeNETi8431.
GeneCardsiNR0B2.
HGNCiHGNC:7961. NR0B2.
HPAiCAB017032.
MalaCardsiNR0B2.
MIMi601665. phenotype.
604630. gene.
neXtProtiNX_Q15466.
OpenTargetsiENSG00000131910.
PharmGKBiPA31747.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3575. Eukaryota.
ENOG410XRZC. LUCA.
GeneTreeiENSGT00390000015719.
HOGENOMiHOG000231151.
HOVERGENiHBG008136.
InParanoidiQ15466.
KOiK08563.
OMAiSPKEYAY.
OrthoDBiEOG091G0FGK.
PhylomeDBiQ15466.
TreeFamiTF332386.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000131910-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.
SignaLinkiQ15466.
SIGNORiQ15466.

Miscellaneous databases

EvolutionaryTraceiQ15466.
GeneWikiiSmall_heterodimer_partner.
GenomeRNAii8431.
PROiQ15466.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000131910.
CleanExiHS_NR0B2.
GenevisibleiQ15466. HS.

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
[Graphical view]
PRINTSiPR00398. STRDHORMONER.
SMARTiSM00430. HOLI. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNR0B2_HUMAN
AccessioniPrimary (citable) accession number: Q15466
Secondary accession number(s): F1D8P5, Q5QP36
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: December 1, 2000
Last modified: November 2, 2016
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.