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Q15431

- SYCP1_HUMAN

UniProt

Q15431 - SYCP1_HUMAN

Protein

Synaptonemal complex protein 1

Gene

SYCP1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 113 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase.

    GO - Molecular functioni

    1. DNA binding Source: ProtInc

    GO - Biological processi

    1. reciprocal meiotic recombination Source: ProtInc
    2. regulation of protein localization Source: Ensembl
    3. spermatogenesis Source: ProtInc
    4. synaptonemal complex assembly Source: HGNC

    Keywords - Biological processi

    Cell cycle, Cell division, Meiosis

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_75792. Meiotic synapsis.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synaptonemal complex protein 1
    Short name:
    SCP-1
    Alternative name(s):
    Cancer/testis antigen 8
    Short name:
    CT8
    Gene namesi
    Name:SYCP1
    Synonyms:SCP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:11487. SYCP1.

    Subcellular locationi

    Nucleus By similarity. Chromosome By similarity
    Note: In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex By similarity.By similarity

    GO - Cellular componenti

    1. central element Source: Ensembl
    2. male germ cell nucleus Source: Ensembl
    3. transverse filament Source: Ensembl

    Keywords - Cellular componenti

    Chromosome, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA36269.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 976976Synaptonemal complex protein 1PRO_0000072362Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki295 – 295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

    Keywords - PTMi

    Isopeptide bond, Ubl conjugation

    Proteomic databases

    MaxQBiQ15431.
    PaxDbiQ15431.
    PRIDEiQ15431.

    PTM databases

    PhosphoSiteiQ15431.

    Expressioni

    Tissue specificityi

    Testis.

    Gene expression databases

    ArrayExpressiQ15431.
    BgeeiQ15431.
    CleanExiHS_SYCP1.
    GenevestigatoriQ15431.

    Organism-specific databases

    HPAiHPA021083.

    Interactioni

    Subunit structurei

    Found in a complex with SYCE1 and SYCE2. Interacts with SYCE1 and SYCE2 By similarity.By similarity

    Protein-protein interaction databases

    BioGridi112714. 2 interactions.
    IntActiQ15431. 1 interaction.
    STRINGi9606.ENSP00000358531.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15431.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili107 – 798692Sequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi117 – 1204Nuclear localization signalSequence Analysis
    Motifi679 – 6824Nuclear localization signalSequence Analysis
    Motifi880 – 8834Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi12 – 10089Asp/Glu-rich (acidic)Add
    BLAST
    Compositional biasi961 – 9699Arg/Lys-rich (basic)

    Domaini

    Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity By similarity.By similarity

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG147666.
    HOGENOMiHOG000154467.
    HOVERGENiHBG059062.
    InParanoidiQ15431.
    OMAiQLNVYEI.
    OrthoDBiEOG7KH9JR.
    PhylomeDBiQ15431.
    TreeFamiTF331737.

    Family and domain databases

    InterProiIPR008827. SCP-1.
    [Graphical view]
    PANTHERiPTHR18878. PTHR18878. 1 hit.
    PfamiPF05483. SCP-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15431-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKQKPFALF VPPRSSSSQV SAVKPQTLGG DSTFFKSFNK CTEDDFEFPF    50
    AKTNLSKNGE NIDSDPALQK VNFLPVLEQV GNSDCHYQEG LKDSDLENSE 100
    GLSRVYSKLY KEAEKIKKWK VSTEAELRQK ESKLQENRKI IEAQRKAIQE 150
    LQFGNEKVSL KLEEGIQENK DLIKENNATR HLCNLLKETC ARSAEKTKKY 200
    EYEREETRQV YMDLNNNIEK MITAFEELRV QAENSRLEMH FKLKEDYEKI 250
    QHLEQEYKKE INDKEKQVSL LLIQITEKEN KMKDLTFLLE ESRDKVNQLE 300
    EKTKLQSENL KQSIEKQHHL TKELEDIKVS LQRSVSTQKA LEEDLQIATK 350
    TICQLTEEKE TQMEESNKAR AAHSFVVTEF ETTVCSLEEL LRTEQQRLEK 400
    NEDQLKILTM ELQKKSSELE EMTKLTNNKE VELEELKKVL GEKETLLYEN 450
    KQFEKIAEEL KGTEQELIGL LQAREKEVHD LEIQLTAITT SEQYYSKEVK 500
    DLKTELENEK LKNTELTSHC NKLSLENKEL TQETSDMTLE LKNQQEDINN 550
    NKKQEERMLK QIENLQETET QLRNELEYVR EELKQKRDEV KCKLDKSEEN 600
    CNNLRKQVEN KNKYIEELQQ ENKALKKKGT AESKQLNVYE IKVNKLELEL 650
    ESAKQKFGEI TDTYQKEIED KKISEENLLE EVEKAKVIAD EAVKLQKEID 700
    KRCQHKIAEM VALMEKHKHQ YDKIIEERDS ELGLYKSKEQ EQSSLRASLE 750
    IELSNLKAEL LSVKKQLEIE REEKEKLKRE AKENTATLKE KKDKKTQTFL 800
    LETPEIYWKL DSKAVPSQTV SRNFTSVDHG ISKDKRDYLW TSAKNTLSTP 850
    LPKAYTVKTP TKPKLQQREN LNIPIEESKK KRKMAFEFDI NSDSSETTDL 900
    LSMVSEEETL KTLYRNNNPP ASHLCVKTPK KAPSSLTTPG STLKFGAIRK 950
    MREDRWAVIA KMDRKKKLKE AEKLFV 976
    Length:976
    Mass (Da):114,192
    Last modified:October 14, 2008 - v2
    Checksum:i43058F1A4B7F57E5
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461F → L in CAA64956. (PubMed:9119375)Curated
    Sequence conflicti106 – 1061Y → F in CAA64956. (PubMed:9119375)Curated
    Sequence conflicti153 – 1531F → C in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti161 – 1611K → T in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti168 – 1681E → D in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti216 – 2161N → S in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti225 – 2262FE → HG in CAA64956. (PubMed:9119375)Curated
    Sequence conflicti350 – 3501K → N in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti360 – 3601E → D in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti400 – 4012KN → NY in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti406 – 4061K → I in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti415 – 4151K → T in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti449 – 4491E → D in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti483 – 51028IQLTA…LENEK → YSYCHYHKWTVLPKRGQRPK LSSKRE in BAA22586. (PubMed:9371398)CuratedAdd
    BLAST
    Sequence conflicti516 – 52813LTSHC…SLENK → YFTLQQASPPPN in BAA22586. (PubMed:9371398)CuratedAdd
    BLAST
    Sequence conflicti549 – 5491N → I in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti560 – 5601K → T in BAA22586. (PubMed:9371398)Curated
    Sequence conflicti941 – 9411S → P in CAA64956. (PubMed:9119375)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti78 – 781E → D.
    Corresponds to variant rs12563933 [ dbSNP | Ensembl ].
    VAR_046993
    Natural varianti805 – 8051E → D.1 Publication
    Corresponds to variant rs1053812 [ dbSNP | Ensembl ].
    VAR_046994

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95654 mRNA. Translation: CAA64956.1.
    D67035 mRNA. Translation: BAA22586.1.
    AL645502, AL358372 Genomic DNA. Translation: CAH70064.1.
    AL358372, AL645502 Genomic DNA. Translation: CAH72847.1.
    CH471122 Genomic DNA. Translation: EAW56622.1.
    BC126266 mRNA. Translation: AAI26267.1.
    CCDSiCCDS879.1.
    RefSeqiNP_001269470.1. NM_001282541.1.
    NP_003167.2. NM_003176.3.
    XP_006710922.1. XM_006710859.1.
    UniGeneiHs.112743.

    Genome annotation databases

    EnsembliENST00000369518; ENSP00000358531; ENSG00000198765.
    ENST00000369522; ENSP00000358535; ENSG00000198765.
    GeneIDi6847.
    KEGGihsa:6847.
    UCSCiuc001efq.3. human.

    Polymorphism databases

    DMDMi209572682.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X95654 mRNA. Translation: CAA64956.1 .
    D67035 mRNA. Translation: BAA22586.1 .
    AL645502 , AL358372 Genomic DNA. Translation: CAH70064.1 .
    AL358372 , AL645502 Genomic DNA. Translation: CAH72847.1 .
    CH471122 Genomic DNA. Translation: EAW56622.1 .
    BC126266 mRNA. Translation: AAI26267.1 .
    CCDSi CCDS879.1.
    RefSeqi NP_001269470.1. NM_001282541.1.
    NP_003167.2. NM_003176.3.
    XP_006710922.1. XM_006710859.1.
    UniGenei Hs.112743.

    3D structure databases

    ProteinModelPortali Q15431.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112714. 2 interactions.
    IntActi Q15431. 1 interaction.
    STRINGi 9606.ENSP00000358531.

    PTM databases

    PhosphoSitei Q15431.

    Polymorphism databases

    DMDMi 209572682.

    Proteomic databases

    MaxQBi Q15431.
    PaxDbi Q15431.
    PRIDEi Q15431.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000369518 ; ENSP00000358531 ; ENSG00000198765 .
    ENST00000369522 ; ENSP00000358535 ; ENSG00000198765 .
    GeneIDi 6847.
    KEGGi hsa:6847.
    UCSCi uc001efq.3. human.

    Organism-specific databases

    CTDi 6847.
    GeneCardsi GC01P115397.
    H-InvDB HIX0028584.
    HGNCi HGNC:11487. SYCP1.
    HPAi HPA021083.
    MIMi 602162. gene.
    neXtProti NX_Q15431.
    PharmGKBi PA36269.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG147666.
    HOGENOMi HOG000154467.
    HOVERGENi HBG059062.
    InParanoidi Q15431.
    OMAi QLNVYEI.
    OrthoDBi EOG7KH9JR.
    PhylomeDBi Q15431.
    TreeFami TF331737.

    Enzyme and pathway databases

    Reactomei REACT_75792. Meiotic synapsis.

    Miscellaneous databases

    ChiTaRSi SYCP1. human.
    GeneWikii SYCP1.
    GenomeRNAii 6847.
    NextBioi 26731.
    PROi Q15431.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15431.
    Bgeei Q15431.
    CleanExi HS_SYCP1.
    Genevestigatori Q15431.

    Family and domain databases

    InterProi IPR008827. SCP-1.
    [Graphical view ]
    PANTHERi PTHR18878. PTHR18878. 1 hit.
    Pfami PF05483. SCP-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene."
      Meuwissen R.L.J., Meerts I., Hoovers J.M.N., Leschot N.J., Heyting C.
      Genomics 39:377-384(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-805.
      Tissue: Testis.
    2. "Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis."
      Kondoh N., Nishina Y., Tsuchida J., Koga M., Tanaka H., Uchida K., Inazawa J., Taketo M., Nozaki M., Nojima H., Matsumiya K., Namiki M., Okuyama A., Nishimune Y.
      Cytogenet. Cell Genet. 78:103-104(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    6. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
      Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
      Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-295.
      Tissue: Mammary cancer.

    Entry informationi

    Entry nameiSYCP1_HUMAN
    AccessioniPrimary (citable) accession number: Q15431
    Secondary accession number(s): O14963, Q5VXJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 113 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3