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Q15431 (SYCP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synaptonemal complex protein 1

Short name=SCP-1
Alternative name(s):
Cancer/testis antigen 8
Short name=CT8
Gene names
Name:SYCP1
Synonyms:SCP1
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length976 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase.

Subunit structure

Found in a complex with SYCE1 and SYCE2. Interacts with SYCE1 and SYCE2 By similarity.

Subcellular location

Nucleus By similarity. Chromosome By similarity. Note: In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex By similarity.

Tissue specificity

Testis.

Domain

Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity By similarity.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 976976Synaptonemal complex protein 1
PRO_0000072362

Regions

Coiled coil107 – 798692 Potential
Motif117 – 1204Nuclear localization signal Potential
Motif679 – 6824Nuclear localization signal Potential
Motif880 – 8834Nuclear localization signal Potential
Compositional bias12 – 10089Asp/Glu-rich (acidic)
Compositional bias961 – 9699Arg/Lys-rich (basic)

Amino acid modifications

Cross-link295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6

Natural variations

Natural variant781E → D.
Corresponds to variant rs12563933 [ dbSNP | Ensembl ].
VAR_046993
Natural variant8051E → D. Ref.1
Corresponds to variant rs1053812 [ dbSNP | Ensembl ].
VAR_046994

Experimental info

Sequence conflict461F → L in CAA64956. Ref.1
Sequence conflict1061Y → F in CAA64956. Ref.1
Sequence conflict1531F → C in BAA22586. Ref.2
Sequence conflict1611K → T in BAA22586. Ref.2
Sequence conflict1681E → D in BAA22586. Ref.2
Sequence conflict2161N → S in BAA22586. Ref.2
Sequence conflict225 – 2262FE → HG in CAA64956. Ref.1
Sequence conflict3501K → N in BAA22586. Ref.2
Sequence conflict3601E → D in BAA22586. Ref.2
Sequence conflict400 – 4012KN → NY in BAA22586. Ref.2
Sequence conflict4061K → I in BAA22586. Ref.2
Sequence conflict4151K → T in BAA22586. Ref.2
Sequence conflict4491E → D in BAA22586. Ref.2
Sequence conflict483 – 51028IQLTA…LENEK → YSYCHYHKWTVLPKRGQRPK LSSKRE in BAA22586. Ref.2
Sequence conflict516 – 52813LTSHC…SLENK → YFTLQQASPPPN in BAA22586. Ref.2
Sequence conflict5491N → I in BAA22586. Ref.2
Sequence conflict5601K → T in BAA22586. Ref.2
Sequence conflict9411S → P in CAA64956. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q15431 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 43058F1A4B7F57E5

FASTA976114,192
        10         20         30         40         50         60 
MEKQKPFALF VPPRSSSSQV SAVKPQTLGG DSTFFKSFNK CTEDDFEFPF AKTNLSKNGE 

        70         80         90        100        110        120 
NIDSDPALQK VNFLPVLEQV GNSDCHYQEG LKDSDLENSE GLSRVYSKLY KEAEKIKKWK 

       130        140        150        160        170        180 
VSTEAELRQK ESKLQENRKI IEAQRKAIQE LQFGNEKVSL KLEEGIQENK DLIKENNATR 

       190        200        210        220        230        240 
HLCNLLKETC ARSAEKTKKY EYEREETRQV YMDLNNNIEK MITAFEELRV QAENSRLEMH 

       250        260        270        280        290        300 
FKLKEDYEKI QHLEQEYKKE INDKEKQVSL LLIQITEKEN KMKDLTFLLE ESRDKVNQLE 

       310        320        330        340        350        360 
EKTKLQSENL KQSIEKQHHL TKELEDIKVS LQRSVSTQKA LEEDLQIATK TICQLTEEKE 

       370        380        390        400        410        420 
TQMEESNKAR AAHSFVVTEF ETTVCSLEEL LRTEQQRLEK NEDQLKILTM ELQKKSSELE 

       430        440        450        460        470        480 
EMTKLTNNKE VELEELKKVL GEKETLLYEN KQFEKIAEEL KGTEQELIGL LQAREKEVHD 

       490        500        510        520        530        540 
LEIQLTAITT SEQYYSKEVK DLKTELENEK LKNTELTSHC NKLSLENKEL TQETSDMTLE 

       550        560        570        580        590        600 
LKNQQEDINN NKKQEERMLK QIENLQETET QLRNELEYVR EELKQKRDEV KCKLDKSEEN 

       610        620        630        640        650        660 
CNNLRKQVEN KNKYIEELQQ ENKALKKKGT AESKQLNVYE IKVNKLELEL ESAKQKFGEI 

       670        680        690        700        710        720 
TDTYQKEIED KKISEENLLE EVEKAKVIAD EAVKLQKEID KRCQHKIAEM VALMEKHKHQ 

       730        740        750        760        770        780 
YDKIIEERDS ELGLYKSKEQ EQSSLRASLE IELSNLKAEL LSVKKQLEIE REEKEKLKRE 

       790        800        810        820        830        840 
AKENTATLKE KKDKKTQTFL LETPEIYWKL DSKAVPSQTV SRNFTSVDHG ISKDKRDYLW 

       850        860        870        880        890        900 
TSAKNTLSTP LPKAYTVKTP TKPKLQQREN LNIPIEESKK KRKMAFEFDI NSDSSETTDL 

       910        920        930        940        950        960 
LSMVSEEETL KTLYRNNNPP ASHLCVKTPK KAPSSLTTPG STLKFGAIRK MREDRWAVIA 

       970 
KMDRKKKLKE AEKLFV 

« Hide

References

« Hide 'large scale' references
[1]"Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene."
Meuwissen R.L.J., Meerts I., Hoovers J.M.N., Leschot N.J., Heyting C.
Genomics 39:377-384(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-805.
Tissue: Testis.
[2]"Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis."
Kondoh N., Nishina Y., Tsuchida J., Koga M., Tanaka H., Uchida K., Inazawa J., Taketo M., Nozaki M., Nojima H., Matsumiya K., Namiki M., Okuyama A., Nishimune Y.
Cytogenet. Cell Genet. 78:103-104(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[3]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[6]"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-295.
Tissue: Mammary cancer.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X95654 mRNA. Translation: CAA64956.1.
D67035 mRNA. Translation: BAA22586.1.
AL645502, AL358372 Genomic DNA. Translation: CAH70064.1.
AL358372, AL645502 Genomic DNA. Translation: CAH72847.1.
CH471122 Genomic DNA. Translation: EAW56622.1.
BC126266 mRNA. Translation: AAI26267.1.
RefSeqNP_001269470.1. NM_001282541.1.
NP_003167.2. NM_003176.3.
UniGeneHs.112743.

3D structure databases

ProteinModelPortalQ15431.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid112714. 2 interactions.
IntActQ15431. 1 interaction.
STRING9606.ENSP00000358531.

PTM databases

PhosphoSiteQ15431.

Polymorphism databases

DMDM209572682.

Proteomic databases

PaxDbQ15431.
PRIDEQ15431.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000369518; ENSP00000358531; ENSG00000198765.
ENST00000369522; ENSP00000358535; ENSG00000198765.
GeneID6847.
KEGGhsa:6847.
UCSCuc001efq.3. human.

Organism-specific databases

CTD6847.
GeneCardsGC01P115397.
H-InvDBHIX0028584.
HGNCHGNC:11487. SYCP1.
HPAHPA021083.
MIM602162. gene.
neXtProtNX_Q15431.
PharmGKBPA36269.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG147666.
HOGENOMHOG000154467.
HOVERGENHBG059062.
InParanoidQ15431.
OMAKQLNVYE.
OrthoDBEOG7KH9JR.
PhylomeDBQ15431.
TreeFamTF331737.

Enzyme and pathway databases

ReactomeREACT_111183. Meiosis.
REACT_115566. Cell Cycle.

Gene expression databases

ArrayExpressQ15431.
BgeeQ15431.
CleanExHS_SYCP1.
GenevestigatorQ15431.

Family and domain databases

InterProIPR008827. SCP-1.
[Graphical view]
PANTHERPTHR18878. PTHR18878. 1 hit.
PfamPF05483. SCP-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSSYCP1. human.
GeneWikiSYCP1.
GenomeRNAi6847.
NextBio26731.
PROQ15431.
SOURCESearch...

Entry information

Entry nameSYCP1_HUMAN
AccessionPrimary (citable) accession number: Q15431
Secondary accession number(s): O14963, Q5VXJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: March 19, 2014
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM