Q15431 (SYCP1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synaptonemal complex protein 1
Short name=SCP-1

Alternative name(s):
Cancer/testis antigen 8
Short name=CT8

Gene names

Name:	SYCP1
Synonyms:	SCP1

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	976 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase.
Subunit structure	Found in a complex with SYCE1 and SYCE2. Interacts with SYCE1 and SYCE2 By similarity.
Subcellular location	Nucleus By similarity. Chromosome By similarity. Note: In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex By similarity.
Tissue specificity	Testis.
Domain	Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity By similarity.

Ontologies

Keywords
Biological process	Cell cycle Cell division Meiosis
Cellular component	Chromosome Nucleus
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Ligand	DNA-binding
PTM	Isopeptide bond Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell division Inferred from electronic annotation. Source: UniProtKB-KW reciprocal meiotic recombination Traceable author statement PubMed 1464329. Source: ProtInc regulation of protein localization Inferred from electronic annotation. Source: Compara spermatogenesis Traceable author statement PubMed 1464329. Source: ProtInc synaptonemal complex assembly Inferred from sequence or structural similarity PubMed 15944401. Source: HGNC
Cellular_component	central element Inferred from electronic annotation. Source: Compara male germ cell nucleus Inferred from electronic annotation. Source: Compara transverse filament Inferred from electronic annotation. Source: Compara
Molecular_function	DNA binding Traceable author statement PubMed 1464329. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 976	976	Synaptonemal complex protein 1		PRO_0000072362
Regions
	Coiled coil	107 – 798	692	Potential
	Motif	117 – 120	4	Nuclear localization signal Potential
	Motif	679 – 682	4	Nuclear localization signal Potential
	Motif	880 – 883	4	Nuclear localization signal Potential
	Compositional bias	12 – 100	89	Asp/Glu-rich (acidic)
	Compositional bias	961 – 969	9	Arg/Lys-rich (basic)
Amino acid modifications
	Cross-link	295		Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) Ref.6
Natural variations
	Natural variant	78	1	E → D. Corresponds to variant rs12563933 [ dbSNP | Ensembl ].		VAR_046993
	Natural variant	805	1	E → D. Ref.1 Corresponds to variant rs1053812 [ dbSNP | Ensembl ].		VAR_046994
Experimental info
	Sequence conflict	46	1	F → L in CAA64956. Ref.1
	Sequence conflict	106	1	Y → F in CAA64956. Ref.1
	Sequence conflict	153	1	F → C in BAA22586. Ref.2
	Sequence conflict	161	1	K → T in BAA22586. Ref.2
	Sequence conflict	168	1	E → D in BAA22586. Ref.2
	Sequence conflict	216	1	N → S in BAA22586. Ref.2
	Sequence conflict	225 – 226	2	FE → HG in CAA64956. Ref.1
	Sequence conflict	350	1	K → N in BAA22586. Ref.2
	Sequence conflict	360	1	E → D in BAA22586. Ref.2
	Sequence conflict	400 – 401	2	KN → NY in BAA22586. Ref.2
	Sequence conflict	406	1	K → I in BAA22586. Ref.2
	Sequence conflict	415	1	K → T in BAA22586. Ref.2
	Sequence conflict	449	1	E → D in BAA22586. Ref.2
	Sequence conflict	483 – 510	28	IQLTA…LENEK → YSYCHYHKWTVLPKRGQRPK LSSKRE in BAA22586. Ref.2
	Sequence conflict	516 – 528	13	LTSHC…SLENK → YFTLQQASPPPN in BAA22586. Ref.2
	Sequence conflict	549	1	N → I in BAA22586. Ref.2
	Sequence conflict	560	1	K → T in BAA22586. Ref.2
	Sequence conflict	941	1	S → P in CAA64956. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q15431 [UniParc]. Last modified October 14, 2008. Version 2. Checksum: 43058F1A4B7F57E5	FASTA	976	114,192
	10 20 30 40 50 60 MEKQKPFALF VPPRSSSSQV SAVKPQTLGG DSTFFKSFNK CTEDDFEFPF AKTNLSKNGE 70 80 90 100 110 120 NIDSDPALQK VNFLPVLEQV GNSDCHYQEG LKDSDLENSE GLSRVYSKLY KEAEKIKKWK 130 140 150 160 170 180 VSTEAELRQK ESKLQENRKI IEAQRKAIQE LQFGNEKVSL KLEEGIQENK DLIKENNATR 190 200 210 220 230 240 HLCNLLKETC ARSAEKTKKY EYEREETRQV YMDLNNNIEK MITAFEELRV QAENSRLEMH 250 260 270 280 290 300 FKLKEDYEKI QHLEQEYKKE INDKEKQVSL LLIQITEKEN KMKDLTFLLE ESRDKVNQLE 310 320 330 340 350 360 EKTKLQSENL KQSIEKQHHL TKELEDIKVS LQRSVSTQKA LEEDLQIATK TICQLTEEKE 370 380 390 400 410 420 TQMEESNKAR AAHSFVVTEF ETTVCSLEEL LRTEQQRLEK NEDQLKILTM ELQKKSSELE 430 440 450 460 470 480 EMTKLTNNKE VELEELKKVL GEKETLLYEN KQFEKIAEEL KGTEQELIGL LQAREKEVHD 490 500 510 520 530 540 LEIQLTAITT SEQYYSKEVK DLKTELENEK LKNTELTSHC NKLSLENKEL TQETSDMTLE 550 560 570 580 590 600 LKNQQEDINN NKKQEERMLK QIENLQETET QLRNELEYVR EELKQKRDEV KCKLDKSEEN 610 620 630 640 650 660 CNNLRKQVEN KNKYIEELQQ ENKALKKKGT AESKQLNVYE IKVNKLELEL ESAKQKFGEI 670 680 690 700 710 720 TDTYQKEIED KKISEENLLE EVEKAKVIAD EAVKLQKEID KRCQHKIAEM VALMEKHKHQ 730 740 750 760 770 780 YDKIIEERDS ELGLYKSKEQ EQSSLRASLE IELSNLKAEL LSVKKQLEIE REEKEKLKRE 790 800 810 820 830 840 AKENTATLKE KKDKKTQTFL LETPEIYWKL DSKAVPSQTV SRNFTSVDHG ISKDKRDYLW 850 860 870 880 890 900 TSAKNTLSTP LPKAYTVKTP TKPKLQQREN LNIPIEESKK KRKMAFEFDI NSDSSETTDL 910 920 930 940 950 960 LSMVSEEETL KTLYRNNNPP ASHLCVKTPK KAPSSLTTPG STLKFGAIRK MREDRWAVIA 970 KMDRKKKLKE AEKLFV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene." Meuwissen R.L.J., Meerts I., Hoovers J.M.N., Leschot N.J., Heyting C. Genomics 39:377-384(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-805. Tissue: Testis.
[2]	"Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis." Kondoh N., Nishina Y., Tsuchida J., Koga M., Tanaka H., Uchida K., Inazawa J., Taketo M., Nozaki M., Nojima H., Matsumiya K., Namiki M., Okuyama A., Nishimune Y. Cytogenet. Cell Genet. 78:103-104(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Testis.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[6]	"Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry." Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D. Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract] Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-295, MASS SPECTROMETRY. Tissue: Mammary cancer.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X95654 mRNA. Translation: CAA64956.1. D67035 mRNA. Translation: BAA22586.1. AL645502, AL358372 Genomic DNA. Translation: CAH70064.1. AL358372, AL645502 Genomic DNA. Translation: CAH72847.1. CH471122 Genomic DNA. Translation: EAW56622.1. BC126266 mRNA. Translation: AAI26267.1.
IPI	IPI00216137.
RefSeq	NP_003167.2. NM_003176.2.
UniGene	Hs.112743.
3D structure databases
ProteinModelPortal	Q15431.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15431. 1 interaction.
STRING	9606.ENSP00000358531.
PTM databases
PhosphoSite	Q15431.
Polymorphism databases
DMDM	209572682.
Proteomic databases
PaxDb	Q15431.
PRIDE	Q15431.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000369518; ENSP00000358531; ENSG00000198765. ENST00000369522; ENSP00000358535; ENSG00000198765.
GeneID	6847.
KEGG	hsa:6847.
UCSC	uc001efq.3. human.
Organism-specific databases
CTD	6847.
GeneCards	GC01P115397.
H-InvDB	HIX0028584.
HGNC	HGNC:11487. SYCP1.
HPA	HPA021083.
MIM	602162. gene.
neXtProt	NX_Q15431.
PharmGKB	PA36269.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG147666.
HOGENOM	HOG000154467.
HOVERGEN	HBG059062.
InParanoid	Q15431.
OMA	KETCARS.
OrthoDB	EOG4TMR1F.
PhylomeDB	Q15431.
Enzyme and pathway databases
Reactome	REACT_111183. Meiosis. REACT_115566. Cell Cycle.
Gene expression databases
ArrayExpress	Q15431.
Bgee	Q15431.
CleanEx	HS_SYCP1.
Genevestigator	Q15431.
GermOnline	ENSG00000198765. Homo sapiens.
Family and domain databases
InterPro	IPR008827. SCP-1. [Graphical view]
PANTHER	PTHR18878. PTHR18878. 1 hit.
Pfam	PF05483. SCP-1. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	SYCP1. human.
GenomeRNAi	6847.
NextBio	26731.
SOURCE	Search...

Entry information

Entry name

SYCP1_HUMAN

Accession

Primary (citable) accession number: Q15431
Secondary accession number(s): O14963, Q5VXJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 14, 2008
Last modified:	April 3, 2013
This is version 103 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.