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Q15431

- SYCP1_HUMAN

UniProt

Q15431 - SYCP1_HUMAN

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Protein
Synaptonemal complex protein 1
Gene
SYCP1, SCP1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Major component of the transverse filaments of synaptonemal complexes (SCS), formed between homologous chromosomes during meiotic prophase.

GO - Molecular functioni

  1. DNA binding Source: ProtInc

GO - Biological processi

  1. reciprocal meiotic recombination Source: ProtInc
  2. regulation of protein localization Source: Ensembl
  3. spermatogenesis Source: ProtInc
  4. synaptonemal complex assembly Source: HGNC
Complete GO annotation...

Keywords - Biological processi

Cell cycle, Cell division, Meiosis

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiREACT_75792. Meiotic synapsis.

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex protein 1
Short name:
SCP-1
Alternative name(s):
Cancer/testis antigen 8
Short name:
CT8
Gene namesi
Name:SYCP1
Synonyms:SCP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:11487. SYCP1.

Subcellular locationi

Nucleus By similarity. Chromosome By similarity
Note: In tripartite segments of synaptonemal complexes, between lateral elements in the nucleus. Found only where the chromosome cores are synapsed. Its N-terminus is found towards the center of the synaptonemal complex while the C-terminus extends well into the lateral domain of the synaptonemal complex By similarity.

GO - Cellular componenti

  1. central element Source: Ensembl
  2. male germ cell nucleus Source: Ensembl
  3. transverse filament Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA36269.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 976976Synaptonemal complex protein 1
PRO_0000072362Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki295 – 295Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication

Keywords - PTMi

Isopeptide bond, Ubl conjugation

Proteomic databases

MaxQBiQ15431.
PaxDbiQ15431.
PRIDEiQ15431.

PTM databases

PhosphoSiteiQ15431.

Expressioni

Tissue specificityi

Testis.

Gene expression databases

ArrayExpressiQ15431.
BgeeiQ15431.
CleanExiHS_SYCP1.
GenevestigatoriQ15431.

Organism-specific databases

HPAiHPA021083.

Interactioni

Subunit structurei

Found in a complex with SYCE1 and SYCE2. Interacts with SYCE1 and SYCE2 By similarity.

Protein-protein interaction databases

BioGridi112714. 2 interactions.
IntActiQ15431. 1 interaction.
STRINGi9606.ENSP00000358531.

Structurei

3D structure databases

ProteinModelPortaliQ15431.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili107 – 798692 Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi117 – 1204Nuclear localization signal Reviewed prediction
Motifi679 – 6824Nuclear localization signal Reviewed prediction
Motifi880 – 8834Nuclear localization signal Reviewed prediction

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi12 – 10089Asp/Glu-rich (acidic)
Add
BLAST
Compositional biasi961 – 9699Arg/Lys-rich (basic)

Domaini

Consists of an alpha-helical stretch of 700 AA residues, flanked by N- and C-terminal globular domains. The C-terminal domain has DNA-binding capacity By similarity.

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG147666.
HOGENOMiHOG000154467.
HOVERGENiHBG059062.
InParanoidiQ15431.
OMAiQLNVYEI.
OrthoDBiEOG7KH9JR.
PhylomeDBiQ15431.
TreeFamiTF331737.

Family and domain databases

InterProiIPR008827. SCP-1.
[Graphical view]
PANTHERiPTHR18878. PTHR18878. 1 hit.
PfamiPF05483. SCP-1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15431-1 [UniParc]FASTAAdd to Basket

« Hide

MEKQKPFALF VPPRSSSSQV SAVKPQTLGG DSTFFKSFNK CTEDDFEFPF    50
AKTNLSKNGE NIDSDPALQK VNFLPVLEQV GNSDCHYQEG LKDSDLENSE 100
GLSRVYSKLY KEAEKIKKWK VSTEAELRQK ESKLQENRKI IEAQRKAIQE 150
LQFGNEKVSL KLEEGIQENK DLIKENNATR HLCNLLKETC ARSAEKTKKY 200
EYEREETRQV YMDLNNNIEK MITAFEELRV QAENSRLEMH FKLKEDYEKI 250
QHLEQEYKKE INDKEKQVSL LLIQITEKEN KMKDLTFLLE ESRDKVNQLE 300
EKTKLQSENL KQSIEKQHHL TKELEDIKVS LQRSVSTQKA LEEDLQIATK 350
TICQLTEEKE TQMEESNKAR AAHSFVVTEF ETTVCSLEEL LRTEQQRLEK 400
NEDQLKILTM ELQKKSSELE EMTKLTNNKE VELEELKKVL GEKETLLYEN 450
KQFEKIAEEL KGTEQELIGL LQAREKEVHD LEIQLTAITT SEQYYSKEVK 500
DLKTELENEK LKNTELTSHC NKLSLENKEL TQETSDMTLE LKNQQEDINN 550
NKKQEERMLK QIENLQETET QLRNELEYVR EELKQKRDEV KCKLDKSEEN 600
CNNLRKQVEN KNKYIEELQQ ENKALKKKGT AESKQLNVYE IKVNKLELEL 650
ESAKQKFGEI TDTYQKEIED KKISEENLLE EVEKAKVIAD EAVKLQKEID 700
KRCQHKIAEM VALMEKHKHQ YDKIIEERDS ELGLYKSKEQ EQSSLRASLE 750
IELSNLKAEL LSVKKQLEIE REEKEKLKRE AKENTATLKE KKDKKTQTFL 800
LETPEIYWKL DSKAVPSQTV SRNFTSVDHG ISKDKRDYLW TSAKNTLSTP 850
LPKAYTVKTP TKPKLQQREN LNIPIEESKK KRKMAFEFDI NSDSSETTDL 900
LSMVSEEETL KTLYRNNNPP ASHLCVKTPK KAPSSLTTPG STLKFGAIRK 950
MREDRWAVIA KMDRKKKLKE AEKLFV 976
Length:976
Mass (Da):114,192
Last modified:October 14, 2008 - v2
Checksum:i43058F1A4B7F57E5
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti78 – 781E → D.
Corresponds to variant rs12563933 [ dbSNP | Ensembl ].
VAR_046993
Natural varianti805 – 8051E → D.1 Publication
Corresponds to variant rs1053812 [ dbSNP | Ensembl ].
VAR_046994

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461F → L in CAA64956. 1 Publication
Sequence conflicti106 – 1061Y → F in CAA64956. 1 Publication
Sequence conflicti153 – 1531F → C in BAA22586. 1 Publication
Sequence conflicti161 – 1611K → T in BAA22586. 1 Publication
Sequence conflicti168 – 1681E → D in BAA22586. 1 Publication
Sequence conflicti216 – 2161N → S in BAA22586. 1 Publication
Sequence conflicti225 – 2262FE → HG in CAA64956. 1 Publication
Sequence conflicti350 – 3501K → N in BAA22586. 1 Publication
Sequence conflicti360 – 3601E → D in BAA22586. 1 Publication
Sequence conflicti400 – 4012KN → NY in BAA22586. 1 Publication
Sequence conflicti406 – 4061K → I in BAA22586. 1 Publication
Sequence conflicti415 – 4151K → T in BAA22586. 1 Publication
Sequence conflicti449 – 4491E → D in BAA22586. 1 Publication
Sequence conflicti483 – 51028IQLTA…LENEK → YSYCHYHKWTVLPKRGQRPK LSSKRE in BAA22586. 1 Publication
Add
BLAST
Sequence conflicti516 – 52813LTSHC…SLENK → YFTLQQASPPPN in BAA22586. 1 Publication
Add
BLAST
Sequence conflicti549 – 5491N → I in BAA22586. 1 Publication
Sequence conflicti560 – 5601K → T in BAA22586. 1 Publication
Sequence conflicti941 – 9411S → P in CAA64956. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95654 mRNA. Translation: CAA64956.1.
D67035 mRNA. Translation: BAA22586.1.
AL645502, AL358372 Genomic DNA. Translation: CAH70064.1.
AL358372, AL645502 Genomic DNA. Translation: CAH72847.1.
CH471122 Genomic DNA. Translation: EAW56622.1.
BC126266 mRNA. Translation: AAI26267.1.
CCDSiCCDS879.1.
RefSeqiNP_001269470.1. NM_001282541.1.
NP_003167.2. NM_003176.3.
XP_006710922.1. XM_006710859.1.
UniGeneiHs.112743.

Genome annotation databases

EnsembliENST00000369518; ENSP00000358531; ENSG00000198765.
ENST00000369522; ENSP00000358535; ENSG00000198765.
GeneIDi6847.
KEGGihsa:6847.
UCSCiuc001efq.3. human.

Polymorphism databases

DMDMi209572682.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X95654 mRNA. Translation: CAA64956.1 .
D67035 mRNA. Translation: BAA22586.1 .
AL645502 , AL358372 Genomic DNA. Translation: CAH70064.1 .
AL358372 , AL645502 Genomic DNA. Translation: CAH72847.1 .
CH471122 Genomic DNA. Translation: EAW56622.1 .
BC126266 mRNA. Translation: AAI26267.1 .
CCDSi CCDS879.1.
RefSeqi NP_001269470.1. NM_001282541.1.
NP_003167.2. NM_003176.3.
XP_006710922.1. XM_006710859.1.
UniGenei Hs.112743.

3D structure databases

ProteinModelPortali Q15431.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112714. 2 interactions.
IntActi Q15431. 1 interaction.
STRINGi 9606.ENSP00000358531.

PTM databases

PhosphoSitei Q15431.

Polymorphism databases

DMDMi 209572682.

Proteomic databases

MaxQBi Q15431.
PaxDbi Q15431.
PRIDEi Q15431.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000369518 ; ENSP00000358531 ; ENSG00000198765 .
ENST00000369522 ; ENSP00000358535 ; ENSG00000198765 .
GeneIDi 6847.
KEGGi hsa:6847.
UCSCi uc001efq.3. human.

Organism-specific databases

CTDi 6847.
GeneCardsi GC01P115397.
H-InvDB HIX0028584.
HGNCi HGNC:11487. SYCP1.
HPAi HPA021083.
MIMi 602162. gene.
neXtProti NX_Q15431.
PharmGKBi PA36269.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG147666.
HOGENOMi HOG000154467.
HOVERGENi HBG059062.
InParanoidi Q15431.
OMAi QLNVYEI.
OrthoDBi EOG7KH9JR.
PhylomeDBi Q15431.
TreeFami TF331737.

Enzyme and pathway databases

Reactomei REACT_75792. Meiotic synapsis.

Miscellaneous databases

ChiTaRSi SYCP1. human.
GeneWikii SYCP1.
GenomeRNAii 6847.
NextBioi 26731.
PROi Q15431.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15431.
Bgeei Q15431.
CleanExi HS_SYCP1.
Genevestigatori Q15431.

Family and domain databases

InterProi IPR008827. SCP-1.
[Graphical view ]
PANTHERi PTHR18878. PTHR18878. 1 hit.
Pfami PF05483. SCP-1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human synaptonemal complex protein 1 (SCP1): isolation and characterization of the cDNA and chromosomal localization of the gene."
    Meuwissen R.L.J., Meerts I., Hoovers J.M.N., Leschot N.J., Heyting C.
    Genomics 39:377-384(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ASP-805.
    Tissue: Testis.
  2. "Assignment of synaptonemal complex protein 1 (SCP1) to human chromosome 1p13 by fluorescence in situ hybridization and its expression in the testis."
    Kondoh N., Nishina Y., Tsuchida J., Koga M., Tanaka H., Uchida K., Inazawa J., Taketo M., Nozaki M., Nojima H., Matsumiya K., Namiki M., Okuyama A., Nishimune Y.
    Cytogenet. Cell Genet. 78:103-104(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  6. "Tryptic digestion of ubiquitin standards reveals an improved strategy for identifying ubiquitinated proteins by mass spectrometry."
    Denis N.J., Vasilescu J., Lambert J.-P., Smith J.C., Figeys D.
    Proteomics 7:868-874(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: UBIQUITINATION [LARGE SCALE ANALYSIS] AT LYS-295.
    Tissue: Mammary cancer.

Entry informationi

Entry nameiSYCP1_HUMAN
AccessioniPrimary (citable) accession number: Q15431
Secondary accession number(s): O14963, Q5VXJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: September 3, 2014
This is version 112 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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