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Protein

Calponin-3

Gene

CNN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Enzyme and pathway databases

SIGNORiQ15417.

Names & Taxonomyi

Protein namesi
Recommended name:
Calponin-3
Alternative name(s):
Calponin, acidic isoform
Gene namesi
Name:CNN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:2157. CNN3.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: HPA
  • cell-cell adherens junction Source: BHF-UCL
  • cytosol Source: HPA
  • dendritic spine Source: Ensembl
  • focal adhesion Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • postsynaptic density Source: Ensembl

Pathology & Biotechi

Organism-specific databases

DisGeNETi1266.
OpenTargetsiENSG00000117519.
PharmGKBiPA26667.

Polymorphism and mutation databases

DMDMi6225157.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047761 – 329Calponin-3Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei158N6-methyllysineCombined sources1
Modified residuei323PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ15417.
PaxDbiQ15417.
PeptideAtlasiQ15417.
PRIDEiQ15417.

PTM databases

iPTMnetiQ15417.
PhosphoSitePlusiQ15417.
SwissPalmiQ15417.

Expressioni

Tissue specificityi

Expressed in both non-smooth muscle tissues as well as smooth muscle tissues.

Gene expression databases

BgeeiENSG00000117519.
CleanExiHS_CNN3.
ExpressionAtlasiQ15417. baseline and differential.
GenevisibleiQ15417. HS.

Organism-specific databases

HPAiCAB009849.
HPA051237.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107666. 12 interactors.
IntActiQ15417. 9 interactors.
MINTiMINT-5004660.
STRINGi9606.ENSP00000359225.

Structurei

3D structure databases

ProteinModelPortaliQ15417.
SMRiQ15417.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 129Calponin-homologyPROSITE-ProRule annotationAdd BLAST104
Repeati164 – 189Calponin-like 1Add BLAST26
Repeati204 – 229Calponin-like 2Add BLAST26
Repeati243 – 268Calponin-like 3Add BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi290 – 329Asp/Glu-rich (acidic)Add BLAST40

Sequence similaritiesi

Belongs to the calponin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2046. Eukaryota.
COG5199. LUCA.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ15417.
OMAiPREYQYG.
OrthoDBiEOG091G0LY2.
PhylomeDBiQ15417.
TreeFamiTF313921.

Family and domain databases

CDDicd00014. CH. 1 hit.
Gene3Di1.10.418.10. 1 hit.
InterProiView protein in InterPro
IPR001997. Calponin/LIMCH1.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
PfamiView protein in Pfam
PF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiView protein in SMART
SM00033. CH. 1 hit.
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiView protein in PROSITE
PS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15417-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHFNKGPSY GLSAEVKNKI ASKYDHQAEE DLRNWIEEVT GMSIGPNFQL
60 70 80 90 100
GLKDGIILCE LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP
110 120 130 140 150
HDIFEANDLF ENGNMTQVQT TLVALAGLAK TKGFHTTIDI GVKYAEKQTR
160 170 180 190 200
RFDEGKLKAG QSVIGLQMGT NKCASQAGMT AYGTRRHLYD PKMQTDKPFD
210 220 230 240 250
QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN STISLQMGTN
260 270 280 290 300
KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY
310 320
QAEYPDEYHG EYQDDYPRDY QYSDQGIDY
Length:329
Mass (Da):36,414
Last modified:November 1, 1996 - v1
Checksum:iF024E169E821A8D8
GO
Isoform 2 (identifier: Q15417-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Note: No experimental confirmation available.
Show »
Length:288
Mass (Da):31,738
Checksum:iF4592E7F1B1BD6A8
GO
Isoform 3 (identifier: Q15417-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-128: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,380
Checksum:i2CB95FDFA4599145
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21A → S in BAG60421 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0551911 – 41Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_05519283 – 128Missing in isoform 3. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80562 mRNA. Translation: AAB35752.1.
AK312370 mRNA. Translation: BAG35288.1.
AK294141 mRNA. Translation: BAG57467.1.
AK298145 mRNA. Translation: BAG60421.1.
AK316398 mRNA. Translation: BAH14769.1.
CR541848 mRNA. Translation: CAG46646.1.
AC093429 Genomic DNA. No translation available.
AC105942 Genomic DNA. No translation available.
AL359554 Genomic DNA. Translation: CAC36093.1.
CH471097 Genomic DNA. Translation: EAW73029.1.
BC025372 mRNA. Translation: AAH25372.1.
CCDSiCCDS30775.1. [Q15417-1]
CCDS65592.1. [Q15417-2]
CCDS65593.1. [Q15417-3]
PIRiJC4501.
RefSeqiNP_001272984.1. NM_001286055.1. [Q15417-3]
NP_001272985.1. NM_001286056.1. [Q15417-2]
NP_001830.1. NM_001839.4. [Q15417-1]
XP_016855734.1. XM_017000245.1. [Q15417-2]
UniGeneiHs.483454.
Hs.736112.

Genome annotation databases

EnsembliENST00000370206; ENSP00000359225; ENSG00000117519. [Q15417-1]
ENST00000394202; ENSP00000377752; ENSG00000117519. [Q15417-3]
ENST00000545882; ENSP00000440081; ENSG00000117519. [Q15417-2]
GeneIDi1266.
KEGGihsa:1266.
UCSCiuc001dqz.6. human. [Q15417-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCNN3_HUMAN
AccessioniPrimary (citable) accession number: Q15417
Secondary accession number(s): B4DFK6
, B4DP09, F8WA86, Q6FHA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: August 30, 2017
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families