Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q15417

- CNN3_HUMAN

UniProt

Q15417 - CNN3_HUMAN

Protein

Calponin-3

Gene

CNN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 136 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

    GO - Biological processi

    1. actomyosin structure organization Source: InterPro
    2. epithelial cell differentiation Source: UniProt

    Keywords - Ligandi

    Actin-binding, Calmodulin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calponin-3
    Alternative name(s):
    Calponin, acidic isoform
    Gene namesi
    Name:CNN3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:2157. CNN3.

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26667.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 329329Calponin-3PRO_0000204776Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei23 – 231N6-acetyllysineBy similarity
    Modified residuei323 – 3231Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ15417.
    PaxDbiQ15417.
    PeptideAtlasiQ15417.
    PRIDEiQ15417.

    PTM databases

    PhosphoSiteiQ15417.

    Expressioni

    Tissue specificityi

    Expressed in both non-smooth muscle tissues as well as smooth muscle tissues.

    Gene expression databases

    ArrayExpressiQ15417.
    BgeeiQ15417.
    CleanExiHS_CNN3.
    GenevestigatoriQ15417.

    Organism-specific databases

    HPAiCAB009849.
    HPA051237.

    Interactioni

    Protein-protein interaction databases

    BioGridi107666. 4 interactions.
    IntActiQ15417. 7 interactions.
    MINTiMINT-5004660.
    STRINGi9606.ENSP00000359225.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15417.
    SMRiQ15417. Positions 27-132.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 129104CHPROSITE-ProRule annotationAdd
    BLAST
    Repeati164 – 18926Calponin-like 1Add
    BLAST
    Repeati204 – 22926Calponin-like 2Add
    BLAST
    Repeati243 – 26826Calponin-like 3Add
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi290 – 32940Asp/Glu-rich (acidic)Add
    BLAST

    Sequence similaritiesi

    Belongs to the calponin family.Curated
    Contains 3 calponin-like repeats.PROSITE-ProRule annotation
    Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5199.
    HOGENOMiHOG000232113.
    HOVERGENiHBG005186.
    InParanoidiQ15417.
    OMAiDDYPREY.
    OrthoDBiEOG71P2B3.
    PhylomeDBiQ15417.
    TreeFamiTF313921.

    Family and domain databases

    Gene3Di1.10.418.10. 1 hit.
    InterProiIPR001997. Calponin.
    IPR000557. Calponin_repeat.
    IPR001715. CH-domain.
    IPR003096. SM22_calponin.
    [Graphical view]
    PfamiPF00402. Calponin. 3 hits.
    PF00307. CH. 1 hit.
    [Graphical view]
    PRINTSiPR00889. CALPONIN.
    PR00888. SM22CALPONIN.
    SMARTiSM00033. CH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47576. SSF47576. 1 hit.
    PROSITEiPS01052. CALPONIN_1. 3 hits.
    PS51122. CALPONIN_2. 3 hits.
    PS50021. CH. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15417-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTHFNKGPSY GLSAEVKNKI ASKYDHQAEE DLRNWIEEVT GMSIGPNFQL    50
    GLKDGIILCE LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP 100
    HDIFEANDLF ENGNMTQVQT TLVALAGLAK TKGFHTTIDI GVKYAEKQTR 150
    RFDEGKLKAG QSVIGLQMGT NKCASQAGMT AYGTRRHLYD PKMQTDKPFD 200
    QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN STISLQMGTN 250
    KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY 300
    QAEYPDEYHG EYQDDYPRDY QYSDQGIDY 329
    Length:329
    Mass (Da):36,414
    Last modified:November 1, 1996 - v1
    Checksum:iF024E169E821A8D8
    GO
    Isoform 2 (identifier: Q15417-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-41: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:288
    Mass (Da):31,738
    Checksum:iF4592E7F1B1BD6A8
    GO
    Isoform 3 (identifier: Q15417-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         83-128: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:283
    Mass (Da):31,380
    Checksum:i2CB95FDFA4599145
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti21 – 211A → S in BAG60421. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 4141Missing in isoform 2. 1 PublicationVSP_055191Add
    BLAST
    Alternative sequencei83 – 12846Missing in isoform 3. 1 PublicationVSP_055192Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80562 mRNA. Translation: AAB35752.1.
    AK312370 mRNA. Translation: BAG35288.1.
    AK294141 mRNA. Translation: BAG57467.1.
    AK298145 mRNA. Translation: BAG60421.1.
    AK316398 mRNA. Translation: BAH14769.1.
    CR541848 mRNA. Translation: CAG46646.1.
    AC093429 Genomic DNA. No translation available.
    AC105942 Genomic DNA. No translation available.
    AL359554 Genomic DNA. Translation: CAC36093.1.
    CH471097 Genomic DNA. Translation: EAW73029.1.
    BC025372 mRNA. Translation: AAH25372.1.
    CCDSiCCDS30775.1. [Q15417-1]
    CCDS65592.1. [Q15417-2]
    CCDS65593.1. [Q15417-3]
    PIRiJC4501.
    RefSeqiNP_001272984.1. NM_001286055.1.
    NP_001272985.1. NM_001286056.1.
    NP_001830.1. NM_001839.4.
    XP_006710398.1. XM_006710335.1.
    UniGeneiHs.483454.
    Hs.736112.

    Genome annotation databases

    EnsembliENST00000370206; ENSP00000359225; ENSG00000117519. [Q15417-1]
    ENST00000394202; ENSP00000377752; ENSG00000117519. [Q15417-3]
    ENST00000545882; ENSP00000440081; ENSG00000117519. [Q15417-2]
    GeneIDi1266.
    KEGGihsa:1266.
    UCSCiuc001dqz.4. human. [Q15417-1]

    Polymorphism databases

    DMDMi6225157.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S80562 mRNA. Translation: AAB35752.1 .
    AK312370 mRNA. Translation: BAG35288.1 .
    AK294141 mRNA. Translation: BAG57467.1 .
    AK298145 mRNA. Translation: BAG60421.1 .
    AK316398 mRNA. Translation: BAH14769.1 .
    CR541848 mRNA. Translation: CAG46646.1 .
    AC093429 Genomic DNA. No translation available.
    AC105942 Genomic DNA. No translation available.
    AL359554 Genomic DNA. Translation: CAC36093.1 .
    CH471097 Genomic DNA. Translation: EAW73029.1 .
    BC025372 mRNA. Translation: AAH25372.1 .
    CCDSi CCDS30775.1. [Q15417-1 ]
    CCDS65592.1. [Q15417-2 ]
    CCDS65593.1. [Q15417-3 ]
    PIRi JC4501.
    RefSeqi NP_001272984.1. NM_001286055.1.
    NP_001272985.1. NM_001286056.1.
    NP_001830.1. NM_001839.4.
    XP_006710398.1. XM_006710335.1.
    UniGenei Hs.483454.
    Hs.736112.

    3D structure databases

    ProteinModelPortali Q15417.
    SMRi Q15417. Positions 27-132.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107666. 4 interactions.
    IntActi Q15417. 7 interactions.
    MINTi MINT-5004660.
    STRINGi 9606.ENSP00000359225.

    PTM databases

    PhosphoSitei Q15417.

    Polymorphism databases

    DMDMi 6225157.

    Proteomic databases

    MaxQBi Q15417.
    PaxDbi Q15417.
    PeptideAtlasi Q15417.
    PRIDEi Q15417.

    Protocols and materials databases

    DNASUi 1266.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000370206 ; ENSP00000359225 ; ENSG00000117519 . [Q15417-1 ]
    ENST00000394202 ; ENSP00000377752 ; ENSG00000117519 . [Q15417-3 ]
    ENST00000545882 ; ENSP00000440081 ; ENSG00000117519 . [Q15417-2 ]
    GeneIDi 1266.
    KEGGi hsa:1266.
    UCSCi uc001dqz.4. human. [Q15417-1 ]

    Organism-specific databases

    CTDi 1266.
    GeneCardsi GC01M095362.
    HGNCi HGNC:2157. CNN3.
    HPAi CAB009849.
    HPA051237.
    MIMi 602374. gene.
    neXtProti NX_Q15417.
    PharmGKBi PA26667.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5199.
    HOGENOMi HOG000232113.
    HOVERGENi HBG005186.
    InParanoidi Q15417.
    OMAi DDYPREY.
    OrthoDBi EOG71P2B3.
    PhylomeDBi Q15417.
    TreeFami TF313921.

    Miscellaneous databases

    GenomeRNAii 1266.
    NextBioi 35471517.
    PROi Q15417.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15417.
    Bgeei Q15417.
    CleanExi HS_CNN3.
    Genevestigatori Q15417.

    Family and domain databases

    Gene3Di 1.10.418.10. 1 hit.
    InterProi IPR001997. Calponin.
    IPR000557. Calponin_repeat.
    IPR001715. CH-domain.
    IPR003096. SM22_calponin.
    [Graphical view ]
    Pfami PF00402. Calponin. 3 hits.
    PF00307. CH. 1 hit.
    [Graphical view ]
    PRINTSi PR00889. CALPONIN.
    PR00888. SM22CALPONIN.
    SMARTi SM00033. CH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47576. SSF47576. 1 hit.
    PROSITEi PS01052. CALPONIN_1. 3 hits.
    PS51122. CALPONIN_2. 3 hits.
    PS50021. CH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and gene mapping of human basic and acidic calponins."
      Maguchi M., Nishida W., Kohara K., Kuwano A., Kondo I., Hiwada K.
      Biochem. Biophys. Res. Commun. 217:238-244(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Kidney.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Amygdala.
    3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Placenta.
    7. Lubec G., Chen W.-Q., Sun Y.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 54-64, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Fetal brain cortex.
    8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiCNN3_HUMAN
    AccessioniPrimary (citable) accession number: Q15417
    Secondary accession number(s): B4DFK6
    , B4DP09, F8WA86, Q6FHA7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 136 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3