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Q15417

- CNN3_HUMAN

UniProt

Q15417 - CNN3_HUMAN

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Protein

Calponin-3

Gene

CNN3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

GO - Biological processi

  1. actomyosin structure organization Source: InterPro
  2. epithelial cell differentiation Source: UniProt
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Calmodulin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Calponin-3
Alternative name(s):
Calponin, acidic isoform
Gene namesi
Name:CNN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:2157. CNN3.

Subcellular locationi

GO - Cellular componenti

  1. focal adhesion Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26667.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 329329Calponin-3PRO_0000204776Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei23 – 231N6-acetyllysineBy similarity
Modified residuei323 – 3231Phosphoserine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ15417.
PaxDbiQ15417.
PeptideAtlasiQ15417.
PRIDEiQ15417.

PTM databases

PhosphoSiteiQ15417.

Expressioni

Tissue specificityi

Expressed in both non-smooth muscle tissues as well as smooth muscle tissues.

Gene expression databases

BgeeiQ15417.
CleanExiHS_CNN3.
ExpressionAtlasiQ15417. baseline and differential.
GenevestigatoriQ15417.

Organism-specific databases

HPAiCAB009849.
HPA051237.

Interactioni

Protein-protein interaction databases

BioGridi107666. 6 interactions.
IntActiQ15417. 7 interactions.
MINTiMINT-5004660.
STRINGi9606.ENSP00000359225.

Structurei

3D structure databases

ProteinModelPortaliQ15417.
SMRiQ15417. Positions 27-132.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 129104CHPROSITE-ProRule annotationAdd
BLAST
Repeati164 – 18926Calponin-like 1Add
BLAST
Repeati204 – 22926Calponin-like 2Add
BLAST
Repeati243 – 26826Calponin-like 3Add
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi290 – 32940Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the calponin family.Curated
Contains 3 calponin-like repeats.PROSITE-ProRule annotation
Contains 1 CH (calponin-homology) domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5199.
GeneTreeiENSGT00550000074447.
HOGENOMiHOG000232113.
HOVERGENiHBG005186.
InParanoidiQ15417.
OMAiDDYPREY.
OrthoDBiEOG71P2B3.
PhylomeDBiQ15417.
TreeFamiTF313921.

Family and domain databases

Gene3Di1.10.418.10. 1 hit.
InterProiIPR001997. Calponin.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view]
PfamiPF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view]
PRINTSiPR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTiSM00033. CH. 1 hit.
[Graphical view]
SUPFAMiSSF47576. SSF47576. 1 hit.
PROSITEiPS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q15417-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHFNKGPSY GLSAEVKNKI ASKYDHQAEE DLRNWIEEVT GMSIGPNFQL
60 70 80 90 100
GLKDGIILCE LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP
110 120 130 140 150
HDIFEANDLF ENGNMTQVQT TLVALAGLAK TKGFHTTIDI GVKYAEKQTR
160 170 180 190 200
RFDEGKLKAG QSVIGLQMGT NKCASQAGMT AYGTRRHLYD PKMQTDKPFD
210 220 230 240 250
QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN STISLQMGTN
260 270 280 290 300
KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY
310 320
QAEYPDEYHG EYQDDYPRDY QYSDQGIDY
Length:329
Mass (Da):36,414
Last modified:November 1, 1996 - v1
Checksum:iF024E169E821A8D8
GO
Isoform 2 (identifier: Q15417-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Note: No experimental confirmation available.

Show »
Length:288
Mass (Da):31,738
Checksum:iF4592E7F1B1BD6A8
GO
Isoform 3 (identifier: Q15417-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-128: Missing.

Note: No experimental confirmation available.

Show »
Length:283
Mass (Da):31,380
Checksum:i2CB95FDFA4599145
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti21 – 211A → S in BAG60421. (PubMed:14702039)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 4141Missing in isoform 2. 1 PublicationVSP_055191Add
BLAST
Alternative sequencei83 – 12846Missing in isoform 3. 1 PublicationVSP_055192Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80562 mRNA. Translation: AAB35752.1.
AK312370 mRNA. Translation: BAG35288.1.
AK294141 mRNA. Translation: BAG57467.1.
AK298145 mRNA. Translation: BAG60421.1.
AK316398 mRNA. Translation: BAH14769.1.
CR541848 mRNA. Translation: CAG46646.1.
AC093429 Genomic DNA. No translation available.
AC105942 Genomic DNA. No translation available.
AL359554 Genomic DNA. Translation: CAC36093.1.
CH471097 Genomic DNA. Translation: EAW73029.1.
BC025372 mRNA. Translation: AAH25372.1.
CCDSiCCDS30775.1. [Q15417-1]
CCDS65592.1. [Q15417-2]
CCDS65593.1. [Q15417-3]
PIRiJC4501.
RefSeqiNP_001272984.1. NM_001286055.1. [Q15417-3]
NP_001272985.1. NM_001286056.1. [Q15417-2]
NP_001830.1. NM_001839.4. [Q15417-1]
XP_006710398.1. XM_006710335.1. [Q15417-2]
UniGeneiHs.483454.
Hs.736112.

Genome annotation databases

EnsembliENST00000370206; ENSP00000359225; ENSG00000117519. [Q15417-1]
ENST00000394202; ENSP00000377752; ENSG00000117519. [Q15417-3]
ENST00000545882; ENSP00000440081; ENSG00000117519. [Q15417-2]
GeneIDi1266.
KEGGihsa:1266.
UCSCiuc001dqz.4. human. [Q15417-1]

Polymorphism databases

DMDMi6225157.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80562 mRNA. Translation: AAB35752.1 .
AK312370 mRNA. Translation: BAG35288.1 .
AK294141 mRNA. Translation: BAG57467.1 .
AK298145 mRNA. Translation: BAG60421.1 .
AK316398 mRNA. Translation: BAH14769.1 .
CR541848 mRNA. Translation: CAG46646.1 .
AC093429 Genomic DNA. No translation available.
AC105942 Genomic DNA. No translation available.
AL359554 Genomic DNA. Translation: CAC36093.1 .
CH471097 Genomic DNA. Translation: EAW73029.1 .
BC025372 mRNA. Translation: AAH25372.1 .
CCDSi CCDS30775.1. [Q15417-1 ]
CCDS65592.1. [Q15417-2 ]
CCDS65593.1. [Q15417-3 ]
PIRi JC4501.
RefSeqi NP_001272984.1. NM_001286055.1. [Q15417-3 ]
NP_001272985.1. NM_001286056.1. [Q15417-2 ]
NP_001830.1. NM_001839.4. [Q15417-1 ]
XP_006710398.1. XM_006710335.1. [Q15417-2 ]
UniGenei Hs.483454.
Hs.736112.

3D structure databases

ProteinModelPortali Q15417.
SMRi Q15417. Positions 27-132.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 107666. 6 interactions.
IntActi Q15417. 7 interactions.
MINTi MINT-5004660.
STRINGi 9606.ENSP00000359225.

PTM databases

PhosphoSitei Q15417.

Polymorphism databases

DMDMi 6225157.

Proteomic databases

MaxQBi Q15417.
PaxDbi Q15417.
PeptideAtlasi Q15417.
PRIDEi Q15417.

Protocols and materials databases

DNASUi 1266.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000370206 ; ENSP00000359225 ; ENSG00000117519 . [Q15417-1 ]
ENST00000394202 ; ENSP00000377752 ; ENSG00000117519 . [Q15417-3 ]
ENST00000545882 ; ENSP00000440081 ; ENSG00000117519 . [Q15417-2 ]
GeneIDi 1266.
KEGGi hsa:1266.
UCSCi uc001dqz.4. human. [Q15417-1 ]

Organism-specific databases

CTDi 1266.
GeneCardsi GC01M095362.
HGNCi HGNC:2157. CNN3.
HPAi CAB009849.
HPA051237.
MIMi 602374. gene.
neXtProti NX_Q15417.
PharmGKBi PA26667.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5199.
GeneTreei ENSGT00550000074447.
HOGENOMi HOG000232113.
HOVERGENi HBG005186.
InParanoidi Q15417.
OMAi DDYPREY.
OrthoDBi EOG71P2B3.
PhylomeDBi Q15417.
TreeFami TF313921.

Miscellaneous databases

ChiTaRSi CNN3. human.
GenomeRNAii 1266.
NextBioi 35471517.
PROi Q15417.
SOURCEi Search...

Gene expression databases

Bgeei Q15417.
CleanExi HS_CNN3.
ExpressionAtlasi Q15417. baseline and differential.
Genevestigatori Q15417.

Family and domain databases

Gene3Di 1.10.418.10. 1 hit.
InterProi IPR001997. Calponin.
IPR000557. Calponin_repeat.
IPR001715. CH-domain.
IPR003096. SM22_calponin.
[Graphical view ]
Pfami PF00402. Calponin. 3 hits.
PF00307. CH. 1 hit.
[Graphical view ]
PRINTSi PR00889. CALPONIN.
PR00888. SM22CALPONIN.
SMARTi SM00033. CH. 1 hit.
[Graphical view ]
SUPFAMi SSF47576. SSF47576. 1 hit.
PROSITEi PS01052. CALPONIN_1. 3 hits.
PS51122. CALPONIN_2. 3 hits.
PS50021. CH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and gene mapping of human basic and acidic calponins."
    Maguchi M., Nishida W., Kohara K., Kuwano A., Kondo I., Hiwada K.
    Biochem. Biophys. Res. Commun. 217:238-244(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Kidney.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
    Tissue: Amygdala.
  3. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Placenta.
  7. Lubec G., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 54-64, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Fetal brain cortex.
  8. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-323, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiCNN3_HUMAN
AccessioniPrimary (citable) accession number: Q15417
Secondary accession number(s): B4DFK6
, B4DP09, F8WA86, Q6FHA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 26, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3