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Protein

Calponin-3

Gene

CNN3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin, troponin C and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActin-binding, Calmodulin-binding

Enzyme and pathway databases

SIGNORiQ15417

Names & Taxonomyi

Protein namesi
Recommended name:
Calponin-3
Alternative name(s):
Calponin, acidic isoform
Gene namesi
Name:CNN3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000117519.15
HGNCiHGNC:2157 CNN3
MIMi602374 gene
neXtProtiNX_Q15417

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi1266
OpenTargetsiENSG00000117519
PharmGKBiPA26667

Polymorphism and mutation databases

DMDMi6225157

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002047761 – 329Calponin-3Add BLAST329

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei23N6-acetyllysineBy similarity1
Modified residuei158N6-methyllysineCombined sources1
Modified residuei323PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ15417
PaxDbiQ15417
PeptideAtlasiQ15417
PRIDEiQ15417
ProteomicsDBi60582

PTM databases

iPTMnetiQ15417
PhosphoSitePlusiQ15417
SwissPalmiQ15417

Expressioni

Tissue specificityi

Expressed in both non-smooth muscle tissues as well as smooth muscle tissues.

Gene expression databases

BgeeiENSG00000117519
CleanExiHS_CNN3
ExpressionAtlasiQ15417 baseline and differential
GenevisibleiQ15417 HS

Organism-specific databases

HPAiCAB009849
HPA051237

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107666, 14 interactors
CORUMiQ15417
IntActiQ15417, 11 interactors
STRINGi9606.ENSP00000359225

Structurei

3D structure databases

ProteinModelPortaliQ15417
SMRiQ15417
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 130Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST105
Repeati164 – 189Calponin-like 1Add BLAST26
Repeati204 – 229Calponin-like 2Add BLAST26
Repeati243 – 268Calponin-like 3Add BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi290 – 329Asp/Glu-rich (acidic)Add BLAST40

Sequence similaritiesi

Belongs to the calponin family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG2046 Eukaryota
COG5199 LUCA
GeneTreeiENSGT00550000074447
HOGENOMiHOG000232113
HOVERGENiHBG005186
InParanoidiQ15417
OMAiPREYQYG
OrthoDBiEOG091G0LY2
PhylomeDBiQ15417
TreeFamiTF313921

Family and domain databases

CDDicd00014 CH, 1 hit
Gene3Di1.10.418.10, 1 hit
InterProiView protein in InterPro
IPR001997 Calponin/LIMCH1
IPR000557 Calponin_repeat
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR003096 SM22_calponin
PfamiView protein in Pfam
PF00402 Calponin, 3 hits
PF00307 CH, 1 hit
PRINTSiPR00889 CALPONIN
PR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
PROSITEiView protein in PROSITE
PS01052 CALPONIN_1, 3 hits
PS51122 CALPONIN_2, 3 hits
PS50021 CH, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15417-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTHFNKGPSY GLSAEVKNKI ASKYDHQAEE DLRNWIEEVT GMSIGPNFQL
60 70 80 90 100
GLKDGIILCE LINKLQPGSV KKVNESSLNW PQLENIGNFI KAIQAYGMKP
110 120 130 140 150
HDIFEANDLF ENGNMTQVQT TLVALAGLAK TKGFHTTIDI GVKYAEKQTR
160 170 180 190 200
RFDEGKLKAG QSVIGLQMGT NKCASQAGMT AYGTRRHLYD PKMQTDKPFD
210 220 230 240 250
QTTISLQMGT NKGASQAGML APGTRRDIYD QKLTLQPVDN STISLQMGTN
260 270 280 290 300
KVASQKGMSV YGLGRQVYDP KYCAAPTEPV IHNGSQGTGT NGSEISDSDY
310 320
QAEYPDEYHG EYQDDYPRDY QYSDQGIDY
Length:329
Mass (Da):36,414
Last modified:November 1, 1996 - v1
Checksum:iF024E169E821A8D8
GO
Isoform 2 (identifier: Q15417-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-41: Missing.

Note: No experimental confirmation available.
Show »
Length:288
Mass (Da):31,738
Checksum:iF4592E7F1B1BD6A8
GO
Isoform 3 (identifier: Q15417-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     83-128: Missing.

Note: No experimental confirmation available.
Show »
Length:283
Mass (Da):31,380
Checksum:i2CB95FDFA4599145
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti21A → S in BAG60421 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0551911 – 41Missing in isoform 2. 1 PublicationAdd BLAST41
Alternative sequenceiVSP_05519283 – 128Missing in isoform 3. 1 PublicationAdd BLAST46

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S80562 mRNA Translation: AAB35752.1
AK312370 mRNA Translation: BAG35288.1
AK294141 mRNA Translation: BAG57467.1
AK298145 mRNA Translation: BAG60421.1
AK316398 mRNA Translation: BAH14769.1
CR541848 mRNA Translation: CAG46646.1
AC093429 Genomic DNA No translation available.
AC105942 Genomic DNA No translation available.
AL359554 Genomic DNA Translation: CAC36093.1
CH471097 Genomic DNA Translation: EAW73029.1
BC025372 mRNA Translation: AAH25372.1
CCDSiCCDS30775.1 [Q15417-1]
CCDS65592.1 [Q15417-2]
CCDS65593.1 [Q15417-3]
PIRiJC4501
RefSeqiNP_001272984.1, NM_001286055.1 [Q15417-3]
NP_001272985.1, NM_001286056.1 [Q15417-2]
NP_001830.1, NM_001839.4 [Q15417-1]
XP_016855734.1, XM_017000245.1 [Q15417-2]
UniGeneiHs.483454
Hs.736112

Genome annotation databases

EnsembliENST00000370206; ENSP00000359225; ENSG00000117519 [Q15417-1]
ENST00000394202; ENSP00000377752; ENSG00000117519 [Q15417-3]
ENST00000545882; ENSP00000440081; ENSG00000117519 [Q15417-2]
GeneIDi1266
KEGGihsa:1266
UCSCiuc001dqz.6 human [Q15417-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCNN3_HUMAN
AccessioniPrimary (citable) accession number: Q15417
Secondary accession number(s): B4DFK6
, B4DP09, F8WA86, Q6FHA7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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