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Protein

RNA-binding motif protein, Y chromosome, family 1 member F/J

Gene

RBMY1F

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis.1 Publication

Miscellaneous

The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • RNA binding Source: UniProtKB

GO - Biological processi

  • mRNA processing Source: UniProtKB-KW
  • RNA splicing Source: UniProtKB-KW
  • spermatogenesis Source: UniProtKB

Keywordsi

Molecular functionRNA-binding
Biological processmRNA processing, mRNA splicing

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-binding motif protein, Y chromosome, family 1 member F/J
Alternative name(s):
Y chromosome RNA recognition motif 2
Gene namesi
Name:RBMY1F
Synonyms:YRRM2
AND
Name:RBMY1J
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome Y

Organism-specific databases

HGNCiHGNC:23974. RBMY1F.
HGNC:23917. RBMY1J.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134946298.

Polymorphism and mutation databases

BioMutaiRBMY1F.
DMDMi166199747.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003141641 – 496RNA-binding motif protein, Y chromosome, family 1 member F/JAdd BLAST496

Proteomic databases

PaxDbiQ15415.
PeptideAtlasiQ15415.
PRIDEiQ15415.

PTM databases

iPTMnetiQ15415.
PhosphoSitePlusiQ15415.

Expressioni

Tissue specificityi

Testis-specific.1 Publication

Developmental stagei

Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids.

Gene expression databases

BgeeiENSG00000169800.
CleanExiHS_RBMY1F.
ExpressionAtlasiQ15415. baseline.
GenevisibleiQ15415. HS.

Organism-specific databases

HPAiHPA001534.
HPA053147.

Interactioni

Subunit structurei

Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3.

Binary interactionsi

Show more details

GO - Molecular functioni

  • identical protein binding Source: IntAct

Protein-protein interaction databases

BioGridi127736. 17 interactors.
IntActiQ15415. 36 interactors.
STRINGi9606.ENSP00000307155.

Structurei

3D structure databases

ProteinModelPortaliQ15415.
SMRiQ15415.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 85RRMPROSITE-ProRule annotationAdd BLAST78

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi254 – 340Arg-richAdd BLAST87

Phylogenomic databases

eggNOGiENOG410J6JX. Eukaryota.
ENOG4111GI6. LUCA.
GeneTreeiENSGT00710000106295.
HOGENOMiHOG000276235.
HOVERGENiHBG063314.
InParanoidiQ15415.
OMAiAAREYEN.
OrthoDBiEOG091G13K0.
PhylomeDBiQ15415.
TreeFamiTF331833.

Family and domain databases

InterProiView protein in InterPro
IPR012604. RBM1CTR.
IPR000504. RRM_dom.
PfamiView protein in Pfam
PF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
SMARTiView protein in SMART
SM00360. RRM. 1 hit.
SUPFAMiSSF54928. SSF54928. 1 hit.
PROSITEiView protein in PROSITE
PS50102. RRM. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15415-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF
60 70 80 90 100
AFITFENPAD AKNAAKDMNG TSLHGKAIKV EQAKKPSFQS GGRRRPPASS
110 120 130 140 150
RNRSPSGSLR SARGSSGGTR GWLPSHEGHL DDGGYTPDLK MSYSRGLIPV
160 170 180 190 200
KRGPSSRSGG PPPKKSAPSA VARSNSWMGS QGPMSQRREN YGVPPRRATI
210 220 230 240 250
SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY RDNGHSNRDE
260 270 280 290 300
HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNHRSSR
310 320 330 340 350
ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA
360 370 380 390 400
YRDYGHSSWD EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS
410 420 430 440 450
HGAPPARGPR MSYGGSTCHA YSNTRDRYGR SWESYSSCGD FHYCDREHVC
460 470 480 490
RKDQRNPPSL GRVLPDPREA YGSSSYVASI VDGGESRSEK GDSSRY
Length:496
Mass (Da):55,728
Last modified:January 15, 2008 - v2
Checksum:i66AC50828D44E9A8
GO
Isoform 2 (identifier: Q15415-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     397-419: YGTSHGAPPARGPRMSYGGSTCH → DLSWCTTCKRASDVLWWKHLPRI
     420-496: Missing.

Show »
Length:419
Mass (Da):47,454
Checksum:i82D82D712CD1934E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti7P → A in CAA53660 (PubMed:8269511).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_030217397 – 419YGTSH…GSTCH → DLSWCTTCKRASDVLWWKHL PRI in isoform 2. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_030218420 – 496Missing in isoform 2. 1 PublicationAdd BLAST77

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X76060 mRNA. Translation: CAA53660.1.
AK313597 mRNA. Translation: BAG36363.1.
AC023342 Genomic DNA. No translation available.
AC007320 Genomic DNA. No translation available.
BC030018 mRNA. Translation: AAH30018.1.
BC152392 mRNA. Translation: AAI52393.1.
CCDSiCCDS35483.1. [Q15415-1]
CCDS35484.1. [Q15415-1]
PIRiB49418.
RefSeqiNP_001006117.2. NM_001006117.3. [Q15415-1]
NP_001290339.1. NM_001303410.1. [Q15415-2]
NP_689798.1. NM_152585.2. [Q15415-1]
UniGeneiHs.380450.
Hs.567746.

Genome annotation databases

EnsembliENST00000250831; ENSP00000250831; ENSG00000226941. [Q15415-1]
ENST00000303766; ENSP00000307155; ENSG00000169800. [Q15415-1]
GeneIDi159163.
378951.
KEGGihsa:159163.
hsa:378951.
UCSCiuc004fva.4. human. [Q15415-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRBY1F_HUMAN
AccessioniPrimary (citable) accession number: Q15415
Secondary accession number(s): B2R916
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: August 30, 2017
This is version 139 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome Y
    Human chromosome Y: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot