Q15415 (RBY1F_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
April 3, 2013.
Version 98.
History...
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: RNA-binding motif protein, Y chromosome, family 1 member F/J Alternative name(s): Y chromosome RNA recognition motif 2 | |||||||
| Gene names |
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| Organism | Homo sapiens (Human) [Reference proteome] | |||||||
| Taxonomic identifier | 9606 [NCBI] | |||||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo![]() |
Protein attributes
| Sequence length | 496 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level |
General annotation (Comments)
| Function | RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. Ref.1 |
| Subunit structure | Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. |
| Subcellular location | |
| Tissue specificity | Testis-specific. Ref.1 |
| Developmental stage | Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids. |
| Miscellaneous | The RBMY1 proteins are encoded by repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individuals, and some of them may represent pseudogenes. The proteins are very similar, which makes the characterization of each protein difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins. |
| Sequence similarities | Contains 1 RRM (RNA recognition motif) domain. |
Ontologies
| Keywords | |
|---|---|
| Biological process | mRNA processing mRNA splicing |
| Cellular component | Nucleus |
| Coding sequence diversity | Alternative splicing |
| Ligand | RNA-binding |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Biological_process | RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processingInferred from electronic annotation. Source: UniProtKB-KW spermatogenesisNon-traceable author statement Ref.1. Source: UniProtKB |
| Cellular_component | nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular_function | RNA binding Non-traceable author statement Ref.1. Source: UniProtKB nucleotide bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q15415-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q15415-2) The sequence of this isoform differs from the canonical sequence as follows: 397-419: YGTSHGAPPARGPRMSYGGSTCH → DLSWCTTCKRASDVLWWKHLPRI 420-496: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 496 | 496 | RNA-binding motif protein, Y chromosome, family 1 member F/J | PRO_0000314164 | |||||
Regions | |||||||||
| Domain | 8 – 85 | 78 | RRM | ||||||
| Compositional bias | 254 – 340 | 87 | Arg-rich | ||||||
Natural variations | |||||||||
| Alternative sequence | 397 – 419 | 23 | YGTSH…GSTCH → DLSWCTTCKRASDVLWWKHL PRI in isoform 2. | VSP_030217 | |||||
| Alternative sequence | 420 – 496 | 77 | Missing in isoform 2. | VSP_030218 | |||||
Experimental info | |||||||||
| Sequence conflict | 7 | 1 | P → A in CAA53660. Ref.1 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis." Ma K., Inglis J.D., Sharkey A., Bickmore W.A., Hill R.E., Prosser E.J., Speedson R.M., Thomson E.J., Jobling M. Cell 75:1287-1295(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY. Tissue: Testis. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis. |
| [3] | "The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes." Skaletsky H., Kuroda-Kawaguchi T., Minx P.J., Cordum H.S., Hillier L.W., Brown L.G., Repping S., Pyntikova T., Ali J., Bieri T., Chinwalla A., Delehaunty A., Delehaunty K., Du H., Fewell G., Fulton L., Fulton R., Graves T.A. Page D.C.Nature 423:825-837(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Testis. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | X76060 mRNA. Translation: CAA53660.1. AK313597 mRNA. Translation: BAG36363.1. AC023342 Genomic DNA. No translation available. AC007320 Genomic DNA. No translation available. BC030018 mRNA. Translation: AAH30018.1. BC152392 mRNA. Translation: AAI52393.1. |
| IPI | IPI00413949. IPI00879122. |
| PIR | B49418. |
| RefSeq | NP_001006117.2. NM_001006117.2. NP_689798.1. NM_152585.1. |
| UniGene | Hs.567746. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1X5S based on UniProtKB Q14011. |
| ProteinModelPortal | Q15415. |
| SMR | Q15415. Positions 1-108. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | 9606.ENSP00000250831. |
PTM databases | |
| PhosphoSite | Q15415. |
Proteomic databases | |
| PaxDb | Q15415. |
| PRIDE | Q15415. |
Protocols and materials databases | |
| DNASU | 159163. 378951. |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000250831; ENSP00000250831; ENSG00000226941. ENST00000303766; ENSP00000307155; ENSG00000169800. ENST00000414629; ENSP00000405745; ENSG00000226941. |
| GeneID | 159163. 378951. |
| KEGG | hsa:159163. hsa:378951. |
| UCSC | uc004fva.3. human. uc010nxh.3. human. |
Organism-specific databases | |
| CTD | 159163. 378951. |
| GeneCards | GC0YM024314. GC0YP024456. |
| HGNC | HGNC:23974. RBMY1F. HGNC:23917. RBMY1J. |
| HPA | HPA001534. |
| MIM | 400006. gene. |
| neXtProt | NX_Q15415. |
| PharmGKB | PA134946298. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | NOG140744. |
| HOGENOM | HOG000276235. |
| HOVERGEN | HBG063314. |
| InParanoid | Q15415. |
| OMA | KDMNGTS. |
| OrthoDB | EOG4TF0N7. |
| PhylomeDB | Q15415. |
Gene expression databases | |
| Bgee | Q15415. |
| CleanEx | HS_RBMY1F. |
| Genevestigator | Q15415. |
Family and domain databases | |
| Gene3D | 3.30.70.330. 1 hit. |
| InterPro | IPR012677. Nucleotide-bd_a/b_plait. IPR012604. RBM1CTR. IPR000504. RRM_dom. [Graphical view] |
| Pfam | PF08081. RBM1CTR. 1 hit. PF00076. RRM_1. 1 hit. [Graphical view] |
| SMART | SM00360. RRM. 1 hit. [Graphical view] |
| PROSITE | PS50102. RRM. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 87890. |
| SOURCE | Search... |
Entry information
| Entry name | RBY1F_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15415 Secondary accession number(s): B2R916 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome Y Human chromosome Y: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with
