RNA-binding motif protein, Y chromosome, family 1 member A1/C

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Reviewed, UniProtKB/Swiss-Prot Q15414 (RBY1A_HUMAN)

Last modified December 15, 2009. Version 91. History...

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Alternative products · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein names

Recommended name:
    RNA-binding motif protein, Y chromosome, family 1 member A1/C
      Short name=RNA-binding motif protein 1
Alternative name(s):
    Y chromosome RNA recognition motif 1
      Short name=hRBMY

Gene names

Name:	RBMY1A1
Synonyms:	RBM1, RBM2, YRRM1
AND
Name:	RBMY1C

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length	496 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

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General annotation (Comments)

Function	RNA-binding protein which may be involved in spermatogenesis. Required for sperm development, possibly by participating in pre-mRNA splicing in the testis. Ref.1
Subunit structure	Interacts with splicing factor proteins SFRS3/SRP20, TRA2B/SFRS10, KHDRBS1/SAM68 and KHDRBS3. Ref.5 Ref.6 Ref.7
Subcellular location	Nucleus Ref.4.
Tissue specificity	Testis-specific. Ref.1
Developmental stage	Expressed in all of the transcriptionally active stages of germ cell development from spermatogonia through spermatocytes to round spermatids. Ref.4
Miscellaneous	The RBMY1 proteins are encoded by strongly repeated regions of the Y chromosome, mostly within the AZFb region. The exact number of functional copies is unclear and may vary between individues, and some of them may represent pseudogenes. The proteins are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a RBMY1 protein involve all the proteins.
Sequence similarities	Contains 1 RRM (RNA recognition motif) domain.

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Ontologies

Keywords
Biological process	mRNA processing mRNA splicing
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	RNA-binding
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	RNA splicing Inferred from electronic annotation. Source: UniProtKB-KW mRNA processing Inferred from electronic annotation. Source: UniProtKB-KW spermatogenesis Ref.1 Ref.3 Traceable author statement. Source: ProtInc
Cellular component	nucleus Ref.3 Traceable author statement. Source: ProtInc
Molecular function	RNA binding Ref.1 Traceable author statement. Source: ProtInc nucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

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Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15414-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15414-2) The sequence of this isoform differs from the canonical sequence as follows: 327-363: Missing.

Isoform 3 (identifier: Q15414-3) The sequence of this isoform differs from the canonical sequence as follows: 1-140: Missing.

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 496

496

RNA-binding motif protein, Y chromosome, family 1 member A1/C

PRO_0000081899

Regions

Domain

8 – 85

RRM

Compositional bias

254 – 340

Arg-rich

Natural variations

Alternative sequence

1 – 140

140

Missing in isoform 3.

VSP_030219

Alternative sequence

327 – 363

Missing in isoform 2.

VSP_029404

Experimental info

Sequence conflict

K → Q in AAC16917. Ref.3

Secondary structure

496

Helix Strand Turn

Details...

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Sequences

Sequence		Length	Mass (Da)
Isoform 1 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: 3E493C52C7BA9E7E Show »	FASTA	496	55,784
10 20 30 40 50 60 MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD 70 80 90 100 110 120 AKNAAKDMNG KSLHGKAIKV EQAKKPSFQS GGRRRPPASS RNRSPSGSLR SARGSRGGTR 130 140 150 160 170 180 GWLPSHEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS 190 200 210 220 230 240 QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY 250 260 270 280 290 300 RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR 310 320 330 340 350 360 ETREYAPPSR GHGYRDYGHS RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD 370 380 390 400 410 420 EHSSRGYSYH DGYGEALGRD HSEHLSGSSY RDALQRYGTS HGAPPARGPR MSYGGSTCHA 430 440 450 460 470 480 YSNTRDRYGR SWESYSSCGD FHYCDREHVC RKDQRNPPSL GRVLPDPREA CGSSSYVASI 490 VDGGESRSEK GDSSRY « Hide
Isoform 2. Checksum: F3C0267BBEF99E55 Show »	FASTA	459	51,292
10 20 30 40 50 60 MVEADHPGKL FIGGLNRETN EKMLKAVFGK HGPISEVLLI KDRTSKSRGF AFITFENPAD 70 80 90 100 110 120 AKNAAKDMNG KSLHGKAIKV EQAKKPSFQS GGRRRPPASS RNRSPSGSLR SARGSRGGTR 130 140 150 160 170 180 GWLPSHEGHL DDGGYTPDLK MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS 190 200 210 220 230 240 QGPMSQRREN YGVPPRRATI SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY 250 260 270 280 290 300 RDNGHSNRDE HSSRGYRNHR SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR 310 320 330 340 350 360 ETREYAPPSR GHGYRDYGHS RRHESYSRGY SYHDGYGEAL GRDHSEHLSG SSYRDALQRY 370 380 390 400 410 420 GTSHGAPPAR GPRMSYGGST CHAYSNTRDR YGRSWESYSS CGDFHYCDRE HVCRKDQRNP 430 440 450 PSLGRVLPDP REACGSSSYV ASIVDGGESR SEKGDSSRY « Hide
Isoform 3. Checksum: 96D4EAB0E82A3C1C Show »	FASTA	356	40,651
10 20 30 40 50 60 MSYSRGLIPV KRGPSSRSGG PPPKKSAPSA VARSNSWMGS QGPMSQRREN YGVPPRRATI 70 80 90 100 110 120 SSWRNDRMST RHDGYATNDG NHPSCQETRD YAPPSRGYAY RDNGHSNRDE HSSRGYRNHR 130 140 150 160 170 180 SSRETRDYAP PSRGHAYRDY GHSRRDESYS RGYRNRRSSR ETREYAPPSR GHGYRDYGHS 190 200 210 220 230 240 RRHESYSRGY RNHPSSRETR DYAPPHRDYA YRDYGHSSWD EHSSRGYSYH DGYGEALGRD 250 260 270 280 290 300 HSEHLSGSSY RDALQRYGTS HGAPPARGPR MSYGGSTCHA YSNTRDRYGR SWESYSSCGD 310 320 330 340 350 FHYCDREHVC RKDQRNPPSL GRVLPDPREA CGSSSYVASI VDGGESRSEK GDSSRY « Hide

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References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A Y chromosome gene family with RNA-binding protein homology: candidates for the azoospermia factor AZF controlling human spermatogenesis." Ma K., Inglis J.D., Sharkey A., Bickmore W.A., Hill R.E., Prosser E.J., Speedson R.M., Thomson E.J., Jobling M. Cell 75:1287-1295(1993) [PubMed: 8269511] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY. Tissue: Testis.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3). Tissue: Brain and Testis.
[3]	"Structure and organization of the RBMY genes on the human Y chromosome: transposition and amplification of an ancestral autosomal hnRNPG gene." Chai N.-N., Zhou H., Hernandez J., Najmabadi H., Bhasin S., Yen P.H. Genomics 49:283-289(1998) [PubMed: 9598316] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-220 AND 332-496.
[4]	"Expression of RBM in the nuclei of human germ cells is dependent on a critical region of the Y chromosome long arm." Elliott D.J., Millar M.R., Oghene K., Ross A., Kiesewetter F., Pryor J., McIntyre M., Hargreave T.B., Saunders P.T.K., Vogt P.H., Chandley A.C., Cooke H. Proc. Natl. Acad. Sci. U.S.A. 94:3848-3853(1997) [PubMed: 9108067] [Abstract] Cited for: SUBCELLULAR LOCATION, DEVELOPMENTAL STAGE.
[5]	"T-STAR/ETOILE: a novel relative of SAM68 that interacts with an RNA-binding protein implicated in spermatogenesis." Venables J.P., Vernet C., Chew S.L., Elliott D.J., Cowmeadow R.B., Wu J., Cooke H.J., Artzt K., Eperon I.C. Hum. Mol. Genet. 8:959-969(1999) [PubMed: 10332027] [Abstract] Cited for: INTERACTION WITH KHDRBS3.
[6]	"RBMY, a probable human spermatogenesis factor, and other hnRNP G proteins interact with Tra2beta and affect splicing." Venables J.P., Elliott D.J., Makarova O.V., Makarov E.M., Cooke H.J., Eperon E.C. Hum. Mol. Genet. 9:685-694(2000) [PubMed: 10749975] [Abstract] Cited for: INTERACTION WITH TRA2B. Tissue: Testis.
[7]	"The role of potential splicing factors including RBMY, RBMX, hnRNPG-T and STAR proteins in spermatogenesis." Elliott D.J. Int. J. Androl. 27:328-334(2004) [PubMed: 15595951] [Abstract] Cited for: INTERACTION WITH KHDRBS1.
[8]	"The testis-specific human protein RBMY recognizes RNA through a novel mode of interaction." Skrisovska L., Bourgeois C.F., Stefl R., Grellscheid S.-N., Kister L., Wenter P., Elliott D.J., Stevenin J., Allain F.H.-T. EMBO Rep. 8:372-379(2007) [PubMed: 17318228] [Abstract] Cited for: STRUCTURE BY NMR OF 1-109 IN COMPLEX WITH RNA.
+	Additional computationally mapped references.

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Web resources

GeneReviews

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Cross-references

Sequence databases

X76059 mRNA. Translation: CAA53659.1.
BC047768 mRNA. Translation: AAH47768.1.
BC070298 mRNA. Translation: AAH70298.1.
U36608

U36607 Genomic DNA. Translation: AAC16917.1.
U36610, U36609 Genomic DNA. Translation: AAC16918.1.

IPI

IPI00332760.
IPI00872545.
IPI00872656.

PIR

A49418.

RefSeq

NP_005049.1.

UniGene

Hs.380450

3D structure databases

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2FY1	NMR	-	A	1-109	[»]

ModBase

Search...

Protein-protein interaction databases

STRING

Q15414.

Proteomic databases

PRIDE

Q15414.

Genome annotation databases

Ensembl

ENST00000303902; ENSP00000303712; ENSG00000234414; Homo sapiens. [Genome view]
ENST00000382707; ENSP00000372154; ENSG00000234414; Homo sapiens. [Genome view]
ENST00000439108; ENSP00000388006; ENSG00000234414; Homo sapiens. [Genome view]

GeneID

5940.

KEGG

hsa:5940.

UCSC

uc004fup.2. human.
uc010nwz.1. human.

Organism-specific databases

CTD

5940.

GeneCards

GC0YP022084.
GC0YU900014.

H-InvDB

HIX0028489.
HIX0056692.

HGNC

HGNC:9912. RBMY1A1.
HGNC:9914. RBMY1C.

HPA

HPA001534.

MIM

400006. gene.

Orphanet

1646. Chromosome Y deletion.

PharmGKB

PA34279.

GenAtlas

Search...

Phylogenomic databases

HOVERGEN

Q15414.

InParanoid

Q15414.

OMA

DHSGHDY.

Gene expression databases

Bgee

Q15414.

CleanEx

HS_RBMY1A1.

Genevestigator

Q15414.

GermOnline

ENSG00000174622. Homo sapiens.

Family and domain databases

InterPro

IPR012677. a_b_plait_nuc_bd.
IPR012604. RBM1CTR.
IPR000504. RRM_RNP1.
IPR015462. Y_Chr_RRM.
[Graphical view]

Gene3D

G3DSA:3.30.70.330. a_b_plait_nuc_bd. 1 hit.

PANTHER

PTHR10432:SF22. Y_Chr_RRM. 1 hit.

Pfam

PF08081. RBM1CTR. 1 hit.
PF00076. RRM_1. 1 hit.
[Graphical view]

SMART

SM00360. RRM. 1 hit.
[Graphical view]

PROSITE

PS50102. RRM. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

NextBio

23158.

SOURCE

Search...

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Entry information

Entry name

RBY1A_HUMAN

Accession

Primary (citable) accession number: Q15414
Secondary accession number(s): Q15376

Q8NHR0

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 17, 2003
Last sequence update:	November 1, 1996
Last modified:	December 15, 2009
This is version 91 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Relevant documents

Human chromosome Y

Human chromosome Y: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families