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Protein

Ryanodine receptor 3

Gene

RYR3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca2+ release by other calcium channels. Calcium channel that mediates Ca2+-induced Ca2+ release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis (By similarity). Plays a role in cellular calcium signaling.By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei3883Important for activation by Ca(2+)By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Calcium channel, Ion channel, Ligand-gated ion channel, Receptor

Keywords - Biological processi

Calcium transport, Ion transport, Transport

Keywords - Ligandi

Calcium, Calmodulin-binding

Enzyme and pathway databases

BioCyciZFISH:G66-31928-MONOMER.
ReactomeiR-HSA-2672351. Stimuli-sensing channels.
R-HSA-5578775. Ion homeostasis.

Names & Taxonomyi

Protein namesi
Recommended name:
Ryanodine receptor 3
Short name:
RYR-3
Short name:
RyR3
Alternative name(s):
Brain ryanodine receptor-calcium release channel
Brain-type ryanodine receptor
Type 3 ryanodine receptor
Gene namesi
Name:RYR3
Synonyms:HBRR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 15

Organism-specific databases

HGNCiHGNC:10485. RYR3.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 4186CytoplasmicBy similarityAdd BLAST4186
Transmembranei4187 – 4207HelicalSequence analysisAdd BLAST21
Transmembranei4410 – 4430HelicalSequence analysisAdd BLAST21
Transmembranei4485 – 4505HelicalSequence analysisAdd BLAST21
Transmembranei4610 – 4630HelicalSequence analysisAdd BLAST21
Transmembranei4633 – 4653HelicalSequence analysisAdd BLAST21
Transmembranei4672 – 4692HelicalSequence analysisAdd BLAST21
Intramembranei4723 – 4732Pore-formingBy similarity10
Transmembranei4753 – 4773HelicalSequence analysisAdd BLAST21
Topological domaini4774 – 4870CytoplasmicBy similarityAdd BLAST97

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome, Sarcoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi6263.
OpenTargetsiENSG00000198838.
PharmGKBiPA34897.

Chemistry databases

ChEMBLiCHEMBL2062.
GuidetoPHARMACOLOGYi749.

Polymorphism and mutation databases

BioMutaiRYR3.
DMDMi325511382.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002193631 – 4870Ryanodine receptor 3Add BLAST4870

Proteomic databases

EPDiQ15413.
PaxDbiQ15413.
PeptideAtlasiQ15413.
PRIDEiQ15413.

PTM databases

iPTMnetiQ15413.
PhosphoSitePlusiQ15413.

Expressioni

Tissue specificityi

Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus.2 Publications

Gene expression databases

BgeeiENSG00000198838.
CleanExiHS_RYR3.
ExpressionAtlasiQ15413. baseline and differential.
GenevisibleiQ15413. HS.

Organism-specific databases

HPAiCAB006887.

Interactioni

Subunit structurei

Homotetramer. Heterotetramer with RYR2. Interacts with CALM (By similarity). Interacts with FKBP1A. Interacts with SEPN1 (By similarity).By similarity1 Publication

Protein-protein interaction databases

BioGridi112175. 6 interactors.
IntActiQ15413. 2 interactors.
STRINGi9606.ENSP00000373884.

Structurei

Secondary structure

14870
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi2612 – 2635Combined sources24
Turni2646 – 2649Combined sources4
Helixi2657 – 2659Combined sources3
Helixi2662 – 2681Combined sources20
Beta strandi2685 – 2688Combined sources4
Helixi2695 – 2704Combined sources10
Helixi2723 – 2725Combined sources3
Helixi2730 – 2757Combined sources28
Helixi2769 – 2771Combined sources3
Helixi2774 – 2792Combined sources19
Turni2793 – 2795Combined sources3
Beta strandi2796 – 2799Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ERVX-ray1.75A2597-2800[»]
ProteinModelPortaliQ15413.
SMRiQ15413.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini100 – 155MIR 1PROSITE-ProRule annotationAdd BLAST56
Domaini162 – 207MIR 2PROSITE-ProRule annotationAdd BLAST46
Domaini215 – 269MIR 3PROSITE-ProRule annotationAdd BLAST55
Domaini275 – 333MIR 4PROSITE-ProRule annotationAdd BLAST59
Domaini343 – 400MIR 5PROSITE-ProRule annotationAdd BLAST58
Domaini585 – 796B30.2/SPRY 1PROSITE-ProRule annotationAdd BLAST212
Repeati840 – 9531Add BLAST114
Repeati954 – 10682Add BLAST115
Domaini1012 – 1208B30.2/SPRY 2PROSITE-ProRule annotationAdd BLAST197
Domaini1254 – 1466B30.2/SPRY 3PROSITE-ProRule annotationAdd BLAST213
Repeati2589 – 27073Add BLAST119
Repeati2708 – 28204Add BLAST113

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni840 – 28204 X approximate repeatsAdd BLAST1981
Regioni2322 – 2335Interaction with FKBP1A1 PublicationAdd BLAST14
Regioni3469 – 3498Interaction with CALMBy similarityAdd BLAST30

Domaini

The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm.Curated

Sequence similaritiesi

Contains 3 B30.2/SPRY domains.PROSITE-ProRule annotation
Contains 5 MIR domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.
GeneTreeiENSGT00760000119152.
HOGENOMiHOG000231428.
HOVERGENiHBG006699.
InParanoidiQ15413.
KOiK04963.
PhylomeDBiQ15413.
TreeFamiTF315244.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 6 hits.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 1 hit.
SSF47473. SSF47473. 1 hit.
SSF48371. SSF48371. 10 hits.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15413-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL
60 70 80 90 100
EPTSEAKYIP PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH
110 120 130 140 150
RTLLYGHAVL LRHSFSGMYL TCLTTSRSQT DKLAFDVGLR EHATGEACWW
160 170 180 190 200
TIHPASKQRS EGEKVRIGDD LILVSVSSER YLHLSVSNGN IQVDASFMQT
210 220 230 240 250
LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD QNDSQHRRIF
260 270 280 290 300
YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED
310 320 330 340 350
QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD
360 370 380 390 400
SVCFVQHIAS GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC
410 420 430 440 450
QREESQAARI IRNTTALFSQ FVSGNNRTAA PITLPIEEVL QTLQDLIAYF
460 470 480 490 500
QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG MLALVLNCID RLNVYNSVAH
510 520 530 540 550
FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN NLDWLISKLD
560 570 580 590 600
RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI
610 620 630 640 650
LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV
660 670 680 690 700
AEGSAQYKKW YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW
710 720 730 740 750
GGNGVGDDLY SYGFDGLHLW SGRIPRAVAS INQHLLRSDD VVSCCLDLGV
760 770 780 790 800
PSISFRINGQ PVQGMFENFN TDGLFFPVMS FSAGVKVRFL MGGRHGEFKF
810 820 830 840 850
LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGIRDLLGT TQFLSQASFI
860 870 880 890 900
PCPVDTSQVI LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR
910 920 930 940 950
QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK
960 970 980 990 1000
VKLPKNYMMS NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK
1010 1020 1030 1040 1050
QGWTYGIQQD LKNKRNPRLV PYALLDERTK KSNRDSLREA VRTFVGYGYN
1060 1070 1080 1090 1100
IEPSDQELAD SAVEKVSIDK IRFFRVERSY AVRSGKWYFE FEVVTGGDMR
1110 1120 1130 1140 1150
VGWARPGCRP DVELGADDQA FVFEGNRGQR WHQGSGYFGR TWQPGDVVGC
1160 1170 1180 1190 1200
MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR
1210 1220 1230 1240 1250
MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD
1260 1270 1280 1290 1300
HPHIEVMRID GTMDSPPCLK VTHKTFGTQN SNADMIYCRL SMPVECHSSF
1310 1320 1330 1340 1350
SHSPCLDSEA FQKRKQMQEI LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP
1360 1370 1380 1390 1400
DYHLYSEKFD LNKNCTVTVT LGDERGRVHE SVKRSNCYMV WGGDIVASSQ
1410 1420 1430 1440 1450
RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN TKVFPAVFLQ
1460 1470 1480 1490 1500
PTSTSLFQFE LGKLKNAMPL SAAIFRSEEK NPVPQCPPRL DVQTIQPVLW
1510 1520 1530 1540 1550
SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE
1560 1570 1580 1590 1600
QEDLMRFHYH TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG
1610 1620 1630 1640 1650
LLRSGFYDLL ISIHLASAKE RKLMMKNEYI IPITSTTRNI RLFPDESKRH
1660 1670 1680 1690 1700
GLPGVGLRTC LKPGFRFSTP CFVVTGEDHQ KQSPEIPLES LRTKALSMLT
1710 1720 1730 1740 1750
EAVQCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD DDVRQILLLI
1760 1770 1780 1790 1800
DPSVFGEHSA GTEEGAEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP
1810 1820 1830 1840 1850
ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ
1860 1870 1880 1890 1900
ALNMSAALTA RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH
1910 1920 1930 1940 1950
EDLLLHCGVP LEEEEEEEED TSWTGKLCAL VYKIKGPPKP EKEQPTEEEE
1960 1970 1980 1990 2000
RCPTTLKELI SQTMICWAQE DQIQDSELVR MMFNLLRRQY DSIGELLQAL
2010 2020 2030 2040 2050
RKTYTISHTS VSDTINLLAA LGQIRSLLSV RMGKEEELLM INGLGDIMNN
2060 2070 2080 2090 2100
KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF
2110 2120 2130 2140 2150
CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL
2160 2170 2180 2190 2200
ALSLEEPDLE KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR
2210 2220 2230 2240 2250
FAVFVNSESV EENASVVVKL LIRRPECFGP ALRGEGGNGL LAAMQGAIKI
2260 2270 2280 2290 2300
SENPALDLPS QGYKREVSTG DDEEEEEIVH MGNAIMSFYS ALIDLLGRCA
2310 2320 2330 2340 2350
PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP SLNKDGSVSE
2360 2370 2380 2390 2400
PDMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD
2410 2420 2430 2440 2450
TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTEHCTS LIDSTLQTIY
2460 2470 2480 2490 2500
RLSKGRSLTK AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC
2510 2520 2530 2540 2550
KMPLKLLTNH YEQCWKYYCL PSGWGSYGLA VEEELHLTEK LFWGIFDSLS
2560 2570 2580 2590 2600
HKKYDPDLFR MALPCLSAIA GALPPDYLDT RITATLEKQI SVDADGNFDP
2610 2620 2630 2640 2650
KPINTMNFSL PEKLEYIVTK YAEHSHDKWA CDKSQSGWKY GISLDENVKT
2660 2670 2680 2690 2700
HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE
2710 2720 2730 2740 2750
NEKLRSVSQA NQGNSYSPAP LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK
2760 2770 2780 2790 2800
KKLELESKGG GSHPLLVPYD TLTAKEKFKD REKAQDLFKF LQVNGIIVSR
2810 2820 2830 2840 2850
GMKDMELDAS SMEKRFAYKF LKKILKYVDS AQEFIAHLEA IVSSGKTEKS
2860 2870 2880 2890 2900
PRDQEIKFFA KVLLPLVDQY FTSHCLYFLS SPLKPLSSSG YASHKEKEMV
2910 2920 2930 2940 2950
AGLFCKLAAL VRHRISLFGS DSTTMVSCLH ILAQTLDTRT VMKSGSELVK
2960 2970 2980 2990 3000
AGLRAFFENA AEDLEKTSEN LKLGKFTHSR TQIKGVSQNI NYTTVALLPI
3010 3020 3030 3040 3050
LTSIFEHVTQ HQFGMDLLLG DVQISCYHIL CSLYSLGTGK NIYVERQRPA
3060 3070 3080 3090 3100
LGECLASLAA AIPVAFLEPT LNRYNPLSVF NTKTPRERSI LGMPDTVEDM
3110 3120 3130 3140 3150
CPDIPQLEGL MKEINDLAES GARYTEMPHV IEVILPMLCN YLSYWWERGP
3160 3170 3180 3190 3200
ENLPPSTGPC CTKVTSEHLS LILGNILKII NNNLGIDEAS WMKRIAVYAQ
3210 3220 3230 3240 3250
PIISKARPDL LRSHFIPTLE KLKKKAVKTV QEEEQLKADG KGDTQEAELL
3260 3270 3280 3290 3300
ILDEFAVLCR DLYAFYPMLI RYVDNNRSNW LKSPDADSDQ LFRMVAEVFI
3310 3320 3330 3340 3350
LWCKSHNFKR EEQNFVIQNE INNLAFLTGD SKSKMSKAMQ VKSGGQDQER
3360 3370 3380 3390 3400
KKTKRRGDLY SIQTSLIVAA LKKMLPIGLN MCTPGDQELI SLAKSRYSHR
3410 3420 3430 3440 3450
DTDEEVREHL RNNLHLQEKS DDPAVKWQLN LYKDVLKSEE PFNPEKTVER
3460 3470 3480 3490 3500
VQRISAAVFH LEQVEQPLRS KKAVWHKLLS KQRKRAVVAC FRMAPLYNLP
3510 3520 3530 3540 3550
RHRSINLFLH GYQRFWIETE EYSFEEKLVQ DLAKSPKVEE EEEEETEKQP
3560 3570 3580 3590 3600
DPLHQIILYF SRNALTERSK LEDDPLYTSY SSMMAKSCQS GEDEEEDEDK
3610 3620 3630 3640 3650
EKTFEEKEME KQKTLYQQAR LHERGAAEMV LQMISASKGE MSPMVVETLK
3660 3670 3680 3690 3700
LGIAILNGGN AGVQQKMLDY LKEKKDAGFF QSLSGLMQSC SVLDLNAFER
3710 3720 3730 3740 3750
QNKAEGLGMV TEEGTLIVRE RGEKVLQNDE FTRDLFRFLQ LLCEGHNSDF
3760 3770 3780 3790 3800
QNFLRTQMGN TTTVNVIIST VDYLLRLQES ISDFYWYYSG KDIIDESGQH
3810 3820 3830 3840 3850
NFSKALAVTK QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV VGFLHVFANM
3860 3870 3880 3890 3900
QMKLSQDSSQ IELLKELLDL LQDMVVMLLS LLEGNVVNGT IGKQMVDTLV
3910 3920 3930 3940 3950
ESSTNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGIIS KKEFQKAMEG
3960 3970 3980 3990 4000
QKQYTQSEID FLLSCAEADE NDMFNYVDFV DRFHEPAKDI GFNVAVLLTN
4010 4020 4030 4040 4050
LSEHMPNDSR LKCLLDPAES VLNYFEPYLG RIEIMGGAKK IERVYFEISE
4060 4070 4080 4090 4100
SSRTQWEKPQ VKESKRQFIF DVVNEGGEQE KMELFVNFCE DTIFEMQLAS
4110 4120 4130 4140 4150
QISESDSADR PEEEEEDEDS SYVLEIAGEE EEDGSLEPAS AFAMACASVK
4160 4170 4180 4190 4200
RNVTDFLKRA TLKNLRKQYR NVKKMTAKEL VKVLFSFFWM LFVGLFQLLF
4210 4220 4230 4240 4250
TILGGIFQIL WSTVFGGGLV EGAKNIRVTK ILGDMPDPTQ FGIHDDTMEA
4260 4270 4280 4290 4300
ERAEVMEPGI TTELVHFIKG EKGDTDIMSD LFGLHPKKEG SLKHGPEVGL
4310 4320 4330 4340 4350
GDLSEIIGKD EPPTLESTVQ KKRKAQAAEM KAANEAEGKV ESEKADMEDG
4360 4370 4380 4390 4400
EKEDKDKEEE QAEYLWTEVT KKKKRRCGQK VEKPEAFTAN FFKGLEIYQT
4410 4420 4430 4440 4450
KLLHYLARNF YNLRFLALFV AFAINFILLF YKVTEEPLEE ETEDVANLWN
4460 4470 4480 4490 4500
SFNDEEEEEA MVFFVLQEST GYMAPTLRAL AIIHTIISLV CVVGYYCLKV
4510 4520 4530 4540 4550
PLVVFKREKE IARKLEFDGL YITEQPSEDD IKGQWDRLVI NTPSFPNNYW
4560 4570 4580 4590 4600
DKFVKRKVIN KYGDLYGAER IAELLGLDKN ALDFSPVEET KAEAASLVSW
4610 4620 4630 4640 4650
LSSIDMKYHI WKLGVVFTDN SFLYLAWYTT MSVLGHYNNF FFAAHLLDIA
4660 4670 4680 4690 4700
MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV VYLYTVVAFN FFRKFYNKSE
4710 4720 4730 4740 4750
DDDEPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD PYEMYRIVFD
4760 4770 4780 4790 4800
ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVREDMETK CFICGIGNDY
4810 4820 4830 4840 4850
FDTTPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER
4860 4870
CWDFFPAGDC FRKQYEDQLG
Length:4,870
Mass (Da):552,042
Last modified:March 8, 2011 - v3
Checksum:iB953487A89FD480F
GO
Isoform 2 (identifier: Q15413-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3337-3341: Missing.

Show »
Length:4,865
Mass (Da):551,484
Checksum:i1967DCA6B019C276
GO
Isoform 3 (identifier: Q15413-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     3857-3859: DSS → GMW
     3860-4870: Missing.

Show »
Length:3,859
Mass (Da):435,934
Checksum:i637F449F56BDEB60
GO

Sequence cautioni

The sequence BAA23795 differs from that shown. Reason: Frameshift at positions 742 and 766.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti932A → T in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti1081A → P in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti1336A → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti1480K → E in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti1641R → C in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti1641R → C in CAA04798 (PubMed:9515741).Curated1
Sequence conflicti2270G → E in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti2270G → E in CAA04798 (PubMed:9515741).Curated1
Sequence conflicti2355A → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti2433A → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti2546F → I in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti2580T → S in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti2817A → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti3684S → P in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti3698F → S in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti4026E → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti4083E → G in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti4537R → P in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti4604I → L in BAA23795 (PubMed:9395096).Curated1
Sequence conflicti4709C → R in CAA52326 (PubMed:8276408).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024077261R → S.1 Publication1
Natural variantiVAR_057166358I → T.Corresponds to variant rs2304380dbSNPEnsembl.1
Natural variantiVAR_024078494V → I.1 PublicationCorresponds to variant rs2077268dbSNPEnsembl.1
Natural variantiVAR_011404693Y → C.1 Publication1
Natural variantiVAR_011405731I → V.1 PublicationCorresponds to variant rs2229116dbSNPEnsembl.1
Natural variantiVAR_0114061380E → G.1 Publication1
Natural variantiVAR_0114072268Missing .1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0059543337 – 3341Missing in isoform 2. 1 Publication5
Alternative sequenceiVSP_0059553857 – 3859DSS → GMW in isoform 3. Curated3
Alternative sequenceiVSP_0059563860 – 4870Missing in isoform 3. CuratedAdd BLAST1011

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001025 mRNA. Translation: BAA23795.1. Frameshift.
AJ001515 mRNA. Translation: CAA04798.1.
AC010809 Genomic DNA. No translation available.
AC011938 Genomic DNA. No translation available.
AC055874 Genomic DNA. No translation available.
AC067793 Genomic DNA. No translation available.
AC087638 Genomic DNA. No translation available.
AJ002512 mRNA. Translation: CAA05503.1.
X74269 mRNA. Translation: CAA52326.1.
X74270 Genomic DNA. Translation: CAA52327.1.
CCDSiCCDS45210.1. [Q15413-1]
CCDS58351.1. [Q15413-2]
PIRiS37537.
S66631.
RefSeqiNP_001027.3. NM_001036.4. [Q15413-1]
NP_001230925.1. NM_001243996.2. [Q15413-2]
UniGeneiHs.709373.

Genome annotation databases

EnsembliENST00000415757; ENSP00000399610; ENSG00000198838. [Q15413-2]
ENST00000634891; ENSP00000489262; ENSG00000198838. [Q15413-1]
GeneIDi6263.
KEGGihsa:6263.
UCSCiuc001zhi.3. human. [Q15413-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

Ryanodine receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB001025 mRNA. Translation: BAA23795.1. Frameshift.
AJ001515 mRNA. Translation: CAA04798.1.
AC010809 Genomic DNA. No translation available.
AC011938 Genomic DNA. No translation available.
AC055874 Genomic DNA. No translation available.
AC067793 Genomic DNA. No translation available.
AC087638 Genomic DNA. No translation available.
AJ002512 mRNA. Translation: CAA05503.1.
X74269 mRNA. Translation: CAA52326.1.
X74270 Genomic DNA. Translation: CAA52327.1.
CCDSiCCDS45210.1. [Q15413-1]
CCDS58351.1. [Q15413-2]
PIRiS37537.
S66631.
RefSeqiNP_001027.3. NM_001036.4. [Q15413-1]
NP_001230925.1. NM_001243996.2. [Q15413-2]
UniGeneiHs.709373.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4ERVX-ray1.75A2597-2800[»]
ProteinModelPortaliQ15413.
SMRiQ15413.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112175. 6 interactors.
IntActiQ15413. 2 interactors.
STRINGi9606.ENSP00000373884.

Chemistry databases

ChEMBLiCHEMBL2062.
GuidetoPHARMACOLOGYi749.

PTM databases

iPTMnetiQ15413.
PhosphoSitePlusiQ15413.

Polymorphism and mutation databases

BioMutaiRYR3.
DMDMi325511382.

Proteomic databases

EPDiQ15413.
PaxDbiQ15413.
PeptideAtlasiQ15413.
PRIDEiQ15413.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415757; ENSP00000399610; ENSG00000198838. [Q15413-2]
ENST00000634891; ENSP00000489262; ENSG00000198838. [Q15413-1]
GeneIDi6263.
KEGGihsa:6263.
UCSCiuc001zhi.3. human. [Q15413-1]

Organism-specific databases

CTDi6263.
DisGeNETi6263.
GeneCardsiRYR3.
H-InvDBHIX0038065.
HGNCiHGNC:10485. RYR3.
HPAiCAB006887.
MIMi180903. gene.
neXtProtiNX_Q15413.
OpenTargetsiENSG00000198838.
PharmGKBiPA34897.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2243. Eukaryota.
ENOG410YCNW. LUCA.
GeneTreeiENSGT00760000119152.
HOGENOMiHOG000231428.
HOVERGENiHBG006699.
InParanoidiQ15413.
KOiK04963.
PhylomeDBiQ15413.
TreeFamiTF315244.

Enzyme and pathway databases

BioCyciZFISH:G66-31928-MONOMER.
ReactomeiR-HSA-2672351. Stimuli-sensing channels.
R-HSA-5578775. Ion homeostasis.

Miscellaneous databases

ChiTaRSiRYR3. human.
GeneWikiiRYR3.
GenomeRNAii6263.
PROiQ15413.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198838.
CleanExiHS_RYR3.
ExpressionAtlasiQ15413. baseline and differential.
GenevisibleiQ15413. HS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.25.10.30. 1 hit.
InterProiIPR016024. ARM-type_fold.
IPR001870. B30.2/SPRY.
IPR013320. ConA-like_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR000699. RIH_dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR003877. SPRY_dom.
[Graphical view]
PANTHERiPTHR13715. PTHR13715. 6 hits.
PfamiPF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]
PRINTSiPR00795. RYANODINER.
SMARTiSM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]
SUPFAMiSSF100909. SSF100909. 1 hit.
SSF47473. SSF47473. 1 hit.
SSF48371. SSF48371. 10 hits.
SSF49899. SSF49899. 3 hits.
SSF82109. SSF82109. 2 hits.
PROSITEiPS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRYR3_HUMAN
AccessioniPrimary (citable) accession number: Q15413
Secondary accession number(s): O15175, Q15412
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 26, 2001
Last sequence update: March 8, 2011
Last modified: November 2, 2016
This is version 167 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg2+ and ruthenium red (By similarity).By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.