Q15413 (RYR3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Ryanodine receptor 3
Short name=RYR-3
Short name=RyR3

Alternative name(s):
Brain ryanodine receptor-calcium release channel
Brain-type ryanodine receptor
Type 3 ryanodine receptor

Gene names

Name:	RYR3
Synonyms:	HBRR

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	4870 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Calcium channel that mediates the release of Ca2+ from the sarcoplasmic reticulum into the cytoplasm in muscle and thereby plays a role in triggering muscle contraction. May regulate Ca2+ release by other calcium channels. Calcium channel that mediates Ca2+-induced Ca2+ release from the endoplasmic reticulum in non-muscle cells. Contributes to cellular calcium ion homeostasis By similarity. Plays a role in cellular calcium signaling. Ref.8
Subunit structure	Homotetramer. Heterotetramer with RYR2. Interacts with CALM By similarity. Interacts with FKBP1A. Ref.9
Subcellular location	Sarcoplasmic reticulum membrane; Multi-pass membrane protein Probable. Membrane; Multi-pass membrane protein Probable. Microsome membrane; Multi-pass membrane protein By similarity. Note: The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic By similarity.
Tissue specificity	Brain, skeletal muscle, placenta and possibly liver and kidney. In brain, highest levels are found in the cerebellum, hippocampus, caudate nucleus and amygdala, with lower levels in the corpus callosum, substantia nigra and thalamus. Ref.1 Ref.4
Domain	The calcium release channel activity resides in the C-terminal region while the remaining part of the protein resides in the cytoplasm Probable.
Miscellaneous	Channel activity is modulated by the alkaloid ryanodine that binds to the open calcium-release channel with high affinity. At low concentrations, ryanodine maintains the channel in an open conformation. High ryanodine concentrations inhibit channel activity. Channel activity is regulated by calmodulin (CALM). The calcium release is activated by elevated cytoplasmic calcium levels in the micromolar range, by caffeine and adenine nucleotides, such as AMP and ATP. Inhibited by Mg2+ and ruthenium red By similarity.
Sequence similarities	Belongs to the ryanodine receptor (TC 1.A.3.1) family. RYR3 subfamily. [View classification] Contains 3 B30.2/SPRY domains. Contains 5 MIR domains.
Sequence caution	The sequence BAA23795.1 differs from that shown. Reason: Frameshift at positions 742 and 766.

Ontologies

Keywords
Biological process	Calcium transport Ion transport Transport
Cellular component	Endoplasmic reticulum Membrane Microsome Sarcoplasmic reticulum
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Repeat Transmembrane Transmembrane helix
Ligand	Calcium Calmodulin-binding
Molecular function	Calcium channel Ion channel Ligand-gated ion channel Receptor
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cellular calcium ion homeostasis Inferred from electronic annotation. Source: Compara cellular response to ATP Inferred from sequence or structural similarity. Source: UniProtKB cellular response to caffeine Inferred from sequence or structural similarity. Source: UniProtKB cellular response to calcium ion Inferred from sequence or structural similarity. Source: UniProtKB cellular response to magnesium ion Inferred from sequence or structural similarity. Source: UniProtKB protein homotetramerization Inferred from sequence or structural similarity. Source: UniProtKB striated muscle contraction Inferred from electronic annotation. Source: Compara
Cellular_component	integral to membrane Inferred from sequence or structural similarity. Source: UniProtKB junctional membrane complex Inferred from electronic annotation. Source: Compara sarcoplasmic reticulum membrane Inferred from sequence or structural similarity. Source: UniProtKB
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro ryanodine-sensitive calcium-release channel activity Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15413-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15413-2)

The sequence of this isoform differs from the canonical sequence as follows:
     3337-3341: Missing.

Isoform 3 (identifier: Q15413-3)

The sequence of this isoform differs from the canonical sequence as follows:
     3857-3859: DSS → GMW
     3860-4870: Missing.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 4870

4870

Ryanodine receptor 3

PRO_0000219363

Regions

Topological domain

1 – 4186

4186

Cytoplasmic By similarity

Transmembrane

4187 – 4207

21

Helical; Potential

Transmembrane

4410 – 4430

21

Helical; Potential

Transmembrane

4485 – 4505

21

Helical; Potential

Transmembrane

4610 – 4630

21

Helical; Potential

Transmembrane

4633 – 4653

21

Helical; Potential

Transmembrane

4672 – 4692

21

Helical; Potential

Intramembrane

4723 – 4732

10

Pore-forming; By similarity

Transmembrane

4753 – 4773

21

Helical; Potential

Topological domain

4774 – 4870

97

Cytoplasmic By similarity

Domain

100 – 155

56

MIR 1

Domain

162 – 207

46

MIR 2

Domain

215 – 269

55

MIR 3

Domain

275 – 333

59

MIR 4

Domain

343 – 400

58

MIR 5

Domain

585 – 796

212

B30.2/SPRY 1

Repeat

840 – 953

114

1

Repeat

954 – 1068

115

2

Domain

1012 – 1208

197

B30.2/SPRY 2

Domain

1254 – 1466

213

B30.2/SPRY 3

Repeat

2589 – 2707

119

3

Repeat

2708 – 2820

113

4

Region

840 – 2820

1981

4 X approximate repeats

Region

2322 – 2335

14

Interaction with FKBP1A

Region

3469 – 3498

30

Interaction with CALM By similarity

Sites

Site

3883

1

Important for activation by Ca(2+) By similarity

Natural variations

Alternative sequence

3337 – 3341

5

Missing in isoform 2.

VSP_005954

Alternative sequence

3857 – 3859

3

DSS → GMW in isoform 3.

VSP_005955

Alternative sequence

3860 – 4870

1011

Missing in isoform 3.

VSP_005956

Natural variant

261

1

R → S. Ref.2

VAR_024077

Natural variant

358

1

I → T.
Corresponds to variant rs2304380 [ dbSNP | Ensembl ].

VAR_057166

Natural variant

494

1

V → I. Ref.2

VAR_024078

Natural variant

693

1

Y → C. Ref.2

VAR_011404

Natural variant

731

1

I → V. Ref.2

VAR_011405

Natural variant

1380

1

E → G. Ref.2

VAR_011406

Natural variant

2268

1

Missing. Ref.2

VAR_011407

Experimental info

Sequence conflict

932

1

A → T in BAA23795. Ref.1

Sequence conflict

1081

1

A → P in BAA23795. Ref.1

Sequence conflict

1336

1

A → G in BAA23795. Ref.1

Sequence conflict

1480

1

K → E in BAA23795. Ref.1

Sequence conflict

1641

1

R → C in BAA23795. Ref.1

Sequence conflict

1641

1

R → C in CAA04798. Ref.2

Sequence conflict

2270

1

G → E in BAA23795. Ref.1

Sequence conflict

2270

1

G → E in CAA04798. Ref.2

Sequence conflict

2355

1

A → G in BAA23795. Ref.1

Sequence conflict

2433

1

A → G in BAA23795. Ref.1

Sequence conflict

2546

1

F → I in BAA23795. Ref.1

Sequence conflict

2580

1

T → S in BAA23795. Ref.1

Sequence conflict

2817

1

A → G in BAA23795. Ref.1

Sequence conflict

3684

1

S → P in BAA23795. Ref.1

Sequence conflict

3698

1

F → S in BAA23795. Ref.1

Sequence conflict

4026

1

E → G in BAA23795. Ref.1

Sequence conflict

4083

1

E → G in BAA23795. Ref.1

Sequence conflict

4537

1

R → P in BAA23795. Ref.1

Sequence conflict

4604

1

I → L in BAA23795. Ref.1

Sequence conflict

4709

1

C → R in CAA52326. Ref.6

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

4870

Helix Strand Turn

Details...

Helix

2612 – 2635

24

Turn

2646 – 2649

4

Helix

2657 – 2659

3

Helix

2662 – 2681

20

Beta strand

2685 – 2688

4

Helix

2695 – 2704

10

Helix

2723 – 2725

3

Helix

2730 – 2757

28

Helix

2769 – 2771

3

Helix

2774 – 2792

19

Turn

2793 – 2795

3

Beta strand

2796 – 2799

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 8, 2011. Version 3. Checksum: B953487A89FD480F	FASTA	4,870	552,042
	10 20 30 40 50 60 MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP 70 80 90 100 110 120 PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAVL LRHSFSGMYL 130 140 150 160 170 180 TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER 190 200 210 220 230 240 YLHLSVSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD 250 260 270 280 290 300 QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED 310 320 330 340 350 360 QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS 370 380 390 400 410 420 GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ 430 440 450 460 470 480 FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG 490 500 510 520 530 540 MLALVLNCID RLNVYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN 550 560 570 580 590 600 NLDWLISKLD RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI 610 620 630 640 650 660 LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW 670 680 690 700 710 720 YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW 730 740 750 760 770 780 SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS 790 800 810 820 830 840 FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGIRDLLGT 850 860 870 880 890 900 TQFLSQASFI PCPVDTSQVI LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR 910 920 930 940 950 960 QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS 970 980 990 1000 1010 1020 NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV 1030 1040 1050 1060 1070 1080 PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY 1090 1100 1110 1120 1130 1140 AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DVELGADDQA FVFEGNRGQR WHQGSGYFGR 1150 1160 1170 1180 1190 1200 TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR 1210 1220 1230 1240 1250 1260 MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVMRID 1270 1280 1290 1300 1310 1320 GTMDSPPCLK VTHKTFGTQN SNADMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI 1330 1340 1350 1360 1370 1380 LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE 1390 1400 1410 1420 1430 1440 SVKRSNCYMV WGGDIVASSQ RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN 1450 1460 1470 1480 1490 1500 TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFRSEEK NPVPQCPPRL DVQTIQPVLW 1510 1520 1530 1540 1550 1560 SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMRFHYH 1570 1580 1590 1600 1610 1620 TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLASAKE 1630 1640 1650 1660 1670 1680 RKLMMKNEYI IPITSTTRNI RLFPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTGEDHQ 1690 1700 1710 1720 1730 1740 KQSPEIPLES LRTKALSMLT EAVQCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD 1750 1760 1770 1780 1790 1800 DDVRQILLLI DPSVFGEHSA GTEEGAEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP 1810 1820 1830 1840 1850 1860 ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ ALNMSAALTA 1870 1880 1890 1900 1910 1920 RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLLHCGVP LEEEEEEEED 1930 1940 1950 1960 1970 1980 TSWTGKLCAL VYKIKGPPKP EKEQPTEEEE RCPTTLKELI SQTMICWAQE DQIQDSELVR 1990 2000 2010 2020 2030 2040 MMFNLLRRQY DSIGELLQAL RKTYTISHTS VSDTINLLAA LGQIRSLLSV RMGKEEELLM 2050 2060 2070 2080 2090 2100 INGLGDIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF 2110 2120 2130 2140 2150 2160 CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALSLEEPDLE 2170 2180 2190 2200 2210 2220 KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL 2230 2240 2250 2260 2270 2280 LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKREVSTG DDEEEEEIVH 2290 2300 2310 2320 2330 2340 MGNAIMSFYS ALIDLLGRCA PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP 2350 2360 2370 2380 2390 2400 SLNKDGSVSE PDMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD 2410 2420 2430 2440 2450 2460 TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTEHCTS LIDSTLQTIY RLSKGRSLTK 2470 2480 2490 2500 2510 2520 AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC KMPLKLLTNH YEQCWKYYCL 2530 2540 2550 2560 2570 2580 PSGWGSYGLA VEEELHLTEK LFWGIFDSLS HKKYDPDLFR MALPCLSAIA GALPPDYLDT 2590 2600 2610 2620 2630 2640 RITATLEKQI SVDADGNFDP KPINTMNFSL PEKLEYIVTK YAEHSHDKWA CDKSQSGWKY 2650 2660 2670 2680 2690 2700 GISLDENVKT HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE 2710 2720 2730 2740 2750 2760 NEKLRSVSQA NQGNSYSPAP LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK KKLELESKGG 2770 2780 2790 2800 2810 2820 GSHPLLVPYD TLTAKEKFKD REKAQDLFKF LQVNGIIVSR GMKDMELDAS SMEKRFAYKF 2830 2840 2850 2860 2870 2880 LKKILKYVDS AQEFIAHLEA IVSSGKTEKS PRDQEIKFFA KVLLPLVDQY FTSHCLYFLS 2890 2900 2910 2920 2930 2940 SPLKPLSSSG YASHKEKEMV AGLFCKLAAL VRHRISLFGS DSTTMVSCLH ILAQTLDTRT 2950 2960 2970 2980 2990 3000 VMKSGSELVK AGLRAFFENA AEDLEKTSEN LKLGKFTHSR TQIKGVSQNI NYTTVALLPI 3010 3020 3030 3040 3050 3060 LTSIFEHVTQ HQFGMDLLLG DVQISCYHIL CSLYSLGTGK NIYVERQRPA LGECLASLAA 3070 3080 3090 3100 3110 3120 AIPVAFLEPT LNRYNPLSVF NTKTPRERSI LGMPDTVEDM CPDIPQLEGL MKEINDLAES 3130 3140 3150 3160 3170 3180 GARYTEMPHV IEVILPMLCN YLSYWWERGP ENLPPSTGPC CTKVTSEHLS LILGNILKII 3190 3200 3210 3220 3230 3240 NNNLGIDEAS WMKRIAVYAQ PIISKARPDL LRSHFIPTLE KLKKKAVKTV QEEEQLKADG 3250 3260 3270 3280 3290 3300 KGDTQEAELL ILDEFAVLCR DLYAFYPMLI RYVDNNRSNW LKSPDADSDQ LFRMVAEVFI 3310 3320 3330 3340 3350 3360 LWCKSHNFKR EEQNFVIQNE INNLAFLTGD SKSKMSKAMQ VKSGGQDQER KKTKRRGDLY 3370 3380 3390 3400 3410 3420 SIQTSLIVAA LKKMLPIGLN MCTPGDQELI SLAKSRYSHR DTDEEVREHL RNNLHLQEKS 3430 3440 3450 3460 3470 3480 DDPAVKWQLN LYKDVLKSEE PFNPEKTVER VQRISAAVFH LEQVEQPLRS KKAVWHKLLS 3490 3500 3510 3520 3530 3540 KQRKRAVVAC FRMAPLYNLP RHRSINLFLH GYQRFWIETE EYSFEEKLVQ DLAKSPKVEE 3550 3560 3570 3580 3590 3600 EEEEETEKQP DPLHQIILYF SRNALTERSK LEDDPLYTSY SSMMAKSCQS GEDEEEDEDK 3610 3620 3630 3640 3650 3660 EKTFEEKEME KQKTLYQQAR LHERGAAEMV LQMISASKGE MSPMVVETLK LGIAILNGGN 3670 3680 3690 3700 3710 3720 AGVQQKMLDY LKEKKDAGFF QSLSGLMQSC SVLDLNAFER QNKAEGLGMV TEEGTLIVRE 3730 3740 3750 3760 3770 3780 RGEKVLQNDE FTRDLFRFLQ LLCEGHNSDF QNFLRTQMGN TTTVNVIIST VDYLLRLQES 3790 3800 3810 3820 3830 3840 ISDFYWYYSG KDIIDESGQH NFSKALAVTK QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV 3850 3860 3870 3880 3890 3900 VGFLHVFANM QMKLSQDSSQ IELLKELLDL LQDMVVMLLS LLEGNVVNGT IGKQMVDTLV 3910 3920 3930 3940 3950 3960 ESSTNVEMIL KFFDMFLKLK DLTSSDTFKE YDPDGKGIIS KKEFQKAMEG QKQYTQSEID 3970 3980 3990 4000 4010 4020 FLLSCAEADE NDMFNYVDFV DRFHEPAKDI GFNVAVLLTN LSEHMPNDSR LKCLLDPAES 4030 4040 4050 4060 4070 4080 VLNYFEPYLG RIEIMGGAKK IERVYFEISE SSRTQWEKPQ VKESKRQFIF DVVNEGGEQE 4090 4100 4110 4120 4130 4140 KMELFVNFCE DTIFEMQLAS QISESDSADR PEEEEEDEDS SYVLEIAGEE EEDGSLEPAS 4150 4160 4170 4180 4190 4200 AFAMACASVK RNVTDFLKRA TLKNLRKQYR NVKKMTAKEL VKVLFSFFWM LFVGLFQLLF 4210 4220 4230 4240 4250 4260 TILGGIFQIL WSTVFGGGLV EGAKNIRVTK ILGDMPDPTQ FGIHDDTMEA ERAEVMEPGI 4270 4280 4290 4300 4310 4320 TTELVHFIKG EKGDTDIMSD LFGLHPKKEG SLKHGPEVGL GDLSEIIGKD EPPTLESTVQ 4330 4340 4350 4360 4370 4380 KKRKAQAAEM KAANEAEGKV ESEKADMEDG EKEDKDKEEE QAEYLWTEVT KKKKRRCGQK 4390 4400 4410 4420 4430 4440 VEKPEAFTAN FFKGLEIYQT KLLHYLARNF YNLRFLALFV AFAINFILLF YKVTEEPLEE 4450 4460 4470 4480 4490 4500 ETEDVANLWN SFNDEEEEEA MVFFVLQEST GYMAPTLRAL AIIHTIISLV CVVGYYCLKV 4510 4520 4530 4540 4550 4560 PLVVFKREKE IARKLEFDGL YITEQPSEDD IKGQWDRLVI NTPSFPNNYW DKFVKRKVIN 4570 4580 4590 4600 4610 4620 KYGDLYGAER IAELLGLDKN ALDFSPVEET KAEAASLVSW LSSIDMKYHI WKLGVVFTDN 4630 4640 4650 4660 4670 4680 SFLYLAWYTT MSVLGHYNNF FFAAHLLDIA MGFKTLRTIL SSVTHNGKQL VLTVGLLAVV 4690 4700 4710 4720 4730 4740 VYLYTVVAFN FFRKFYNKSE DDDEPDMKCD DMMTCYLFHM YVGVRAGGGI GDEIEDPAGD 4750 4760 4770 4780 4790 4800 PYEMYRIVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ EQVREDMETK CFICGIGNDY 4810 4820 4830 4840 4850 4860 FDTTPHGFET HTLQEHNLAN YLFFLMYLIN KDETEHTGQE SYVWKMYQER CWDFFPAGDC 4870 FRKQYEDQLG
	Isoform 2 [UniParc]. Checksum: 1967DCA6B019C276	FASTA	4,865	551,484
	10 20 30 40 50 60 MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP 70 80 90 100 110 120 PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAVL LRHSFSGMYL 130 140 150 160 170 180 TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER 190 200 210 220 230 240 YLHLSVSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD 250 260 270 280 290 300 QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED 310 320 330 340 350 360 QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS 370 380 390 400 410 420 GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ 430 440 450 460 470 480 FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG 490 500 510 520 530 540 MLALVLNCID RLNVYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN 550 560 570 580 590 600 NLDWLISKLD RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI 610 620 630 640 650 660 LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW 670 680 690 700 710 720 YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW 730 740 750 760 770 780 SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS 790 800 810 820 830 840 FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGIRDLLGT 850 860 870 880 890 900 TQFLSQASFI PCPVDTSQVI LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR 910 920 930 940 950 960 QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS 970 980 990 1000 1010 1020 NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV 1030 1040 1050 1060 1070 1080 PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY 1090 1100 1110 1120 1130 1140 AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DVELGADDQA FVFEGNRGQR WHQGSGYFGR 1150 1160 1170 1180 1190 1200 TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR 1210 1220 1230 1240 1250 1260 MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVMRID 1270 1280 1290 1300 1310 1320 GTMDSPPCLK VTHKTFGTQN SNADMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI 1330 1340 1350 1360 1370 1380 LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE 1390 1400 1410 1420 1430 1440 SVKRSNCYMV WGGDIVASSQ RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN 1450 1460 1470 1480 1490 1500 TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFRSEEK NPVPQCPPRL DVQTIQPVLW 1510 1520 1530 1540 1550 1560 SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMRFHYH 1570 1580 1590 1600 1610 1620 TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLASAKE 1630 1640 1650 1660 1670 1680 RKLMMKNEYI IPITSTTRNI RLFPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTGEDHQ 1690 1700 1710 1720 1730 1740 KQSPEIPLES LRTKALSMLT EAVQCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD 1750 1760 1770 1780 1790 1800 DDVRQILLLI DPSVFGEHSA GTEEGAEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP 1810 1820 1830 1840 1850 1860 ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ ALNMSAALTA 1870 1880 1890 1900 1910 1920 RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLLHCGVP LEEEEEEEED 1930 1940 1950 1960 1970 1980 TSWTGKLCAL VYKIKGPPKP EKEQPTEEEE RCPTTLKELI SQTMICWAQE DQIQDSELVR 1990 2000 2010 2020 2030 2040 MMFNLLRRQY DSIGELLQAL RKTYTISHTS VSDTINLLAA LGQIRSLLSV RMGKEEELLM 2050 2060 2070 2080 2090 2100 INGLGDIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF 2110 2120 2130 2140 2150 2160 CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALSLEEPDLE 2170 2180 2190 2200 2210 2220 KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL 2230 2240 2250 2260 2270 2280 LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKREVSTG DDEEEEEIVH 2290 2300 2310 2320 2330 2340 MGNAIMSFYS ALIDLLGRCA PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP 2350 2360 2370 2380 2390 2400 SLNKDGSVSE PDMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD 2410 2420 2430 2440 2450 2460 TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTEHCTS LIDSTLQTIY RLSKGRSLTK 2470 2480 2490 2500 2510 2520 AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC KMPLKLLTNH YEQCWKYYCL 2530 2540 2550 2560 2570 2580 PSGWGSYGLA VEEELHLTEK LFWGIFDSLS HKKYDPDLFR MALPCLSAIA GALPPDYLDT 2590 2600 2610 2620 2630 2640 RITATLEKQI SVDADGNFDP KPINTMNFSL PEKLEYIVTK YAEHSHDKWA CDKSQSGWKY 2650 2660 2670 2680 2690 2700 GISLDENVKT HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE 2710 2720 2730 2740 2750 2760 NEKLRSVSQA NQGNSYSPAP LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK KKLELESKGG 2770 2780 2790 2800 2810 2820 GSHPLLVPYD TLTAKEKFKD REKAQDLFKF LQVNGIIVSR GMKDMELDAS SMEKRFAYKF 2830 2840 2850 2860 2870 2880 LKKILKYVDS AQEFIAHLEA IVSSGKTEKS PRDQEIKFFA KVLLPLVDQY FTSHCLYFLS 2890 2900 2910 2920 2930 2940 SPLKPLSSSG YASHKEKEMV AGLFCKLAAL VRHRISLFGS DSTTMVSCLH ILAQTLDTRT 2950 2960 2970 2980 2990 3000 VMKSGSELVK AGLRAFFENA AEDLEKTSEN LKLGKFTHSR TQIKGVSQNI NYTTVALLPI 3010 3020 3030 3040 3050 3060 LTSIFEHVTQ HQFGMDLLLG DVQISCYHIL CSLYSLGTGK NIYVERQRPA LGECLASLAA 3070 3080 3090 3100 3110 3120 AIPVAFLEPT LNRYNPLSVF NTKTPRERSI LGMPDTVEDM CPDIPQLEGL MKEINDLAES 3130 3140 3150 3160 3170 3180 GARYTEMPHV IEVILPMLCN YLSYWWERGP ENLPPSTGPC CTKVTSEHLS LILGNILKII 3190 3200 3210 3220 3230 3240 NNNLGIDEAS WMKRIAVYAQ PIISKARPDL LRSHFIPTLE KLKKKAVKTV QEEEQLKADG 3250 3260 3270 3280 3290 3300 KGDTQEAELL ILDEFAVLCR DLYAFYPMLI RYVDNNRSNW LKSPDADSDQ LFRMVAEVFI 3310 3320 3330 3340 3350 3360 LWCKSHNFKR EEQNFVIQNE INNLAFLTGD SKSKMSKSGG QDQERKKTKR RGDLYSIQTS 3370 3380 3390 3400 3410 3420 LIVAALKKML PIGLNMCTPG DQELISLAKS RYSHRDTDEE VREHLRNNLH LQEKSDDPAV 3430 3440 3450 3460 3470 3480 KWQLNLYKDV LKSEEPFNPE KTVERVQRIS AAVFHLEQVE QPLRSKKAVW HKLLSKQRKR 3490 3500 3510 3520 3530 3540 AVVACFRMAP LYNLPRHRSI NLFLHGYQRF WIETEEYSFE EKLVQDLAKS PKVEEEEEEE 3550 3560 3570 3580 3590 3600 TEKQPDPLHQ IILYFSRNAL TERSKLEDDP LYTSYSSMMA KSCQSGEDEE EDEDKEKTFE 3610 3620 3630 3640 3650 3660 EKEMEKQKTL YQQARLHERG AAEMVLQMIS ASKGEMSPMV VETLKLGIAI LNGGNAGVQQ 3670 3680 3690 3700 3710 3720 KMLDYLKEKK DAGFFQSLSG LMQSCSVLDL NAFERQNKAE GLGMVTEEGT LIVRERGEKV 3730 3740 3750 3760 3770 3780 LQNDEFTRDL FRFLQLLCEG HNSDFQNFLR TQMGNTTTVN VIISTVDYLL RLQESISDFY 3790 3800 3810 3820 3830 3840 WYYSGKDIID ESGQHNFSKA LAVTKQIFNS LTEYIQGPCI GNQQSLAHSR LWDAVVGFLH 3850 3860 3870 3880 3890 3900 VFANMQMKLS QDSSQIELLK ELLDLLQDMV VMLLSLLEGN VVNGTIGKQM VDTLVESSTN 3910 3920 3930 3940 3950 3960 VEMILKFFDM FLKLKDLTSS DTFKEYDPDG KGIISKKEFQ KAMEGQKQYT QSEIDFLLSC 3970 3980 3990 4000 4010 4020 AEADENDMFN YVDFVDRFHE PAKDIGFNVA VLLTNLSEHM PNDSRLKCLL DPAESVLNYF 4030 4040 4050 4060 4070 4080 EPYLGRIEIM GGAKKIERVY FEISESSRTQ WEKPQVKESK RQFIFDVVNE GGEQEKMELF 4090 4100 4110 4120 4130 4140 VNFCEDTIFE MQLASQISES DSADRPEEEE EDEDSSYVLE IAGEEEEDGS LEPASAFAMA 4150 4160 4170 4180 4190 4200 CASVKRNVTD FLKRATLKNL RKQYRNVKKM TAKELVKVLF SFFWMLFVGL FQLLFTILGG 4210 4220 4230 4240 4250 4260 IFQILWSTVF GGGLVEGAKN IRVTKILGDM PDPTQFGIHD DTMEAERAEV MEPGITTELV 4270 4280 4290 4300 4310 4320 HFIKGEKGDT DIMSDLFGLH PKKEGSLKHG PEVGLGDLSE IIGKDEPPTL ESTVQKKRKA 4330 4340 4350 4360 4370 4380 QAAEMKAANE AEGKVESEKA DMEDGEKEDK DKEEEQAEYL WTEVTKKKKR RCGQKVEKPE 4390 4400 4410 4420 4430 4440 AFTANFFKGL EIYQTKLLHY LARNFYNLRF LALFVAFAIN FILLFYKVTE EPLEEETEDV 4450 4460 4470 4480 4490 4500 ANLWNSFNDE EEEEAMVFFV LQESTGYMAP TLRALAIIHT IISLVCVVGY YCLKVPLVVF 4510 4520 4530 4540 4550 4560 KREKEIARKL EFDGLYITEQ PSEDDIKGQW DRLVINTPSF PNNYWDKFVK RKVINKYGDL 4570 4580 4590 4600 4610 4620 YGAERIAELL GLDKNALDFS PVEETKAEAA SLVSWLSSID MKYHIWKLGV VFTDNSFLYL 4630 4640 4650 4660 4670 4680 AWYTTMSVLG HYNNFFFAAH LLDIAMGFKT LRTILSSVTH NGKQLVLTVG LLAVVVYLYT 4690 4700 4710 4720 4730 4740 VVAFNFFRKF YNKSEDDDEP DMKCDDMMTC YLFHMYVGVR AGGGIGDEIE DPAGDPYEMY 4750 4760 4770 4780 4790 4800 RIVFDITFFF FVIVILLAII QGLIIDAFGE LRDQQEQVRE DMETKCFICG IGNDYFDTTP 4810 4820 4830 4840 4850 4860 HGFETHTLQE HNLANYLFFL MYLINKDETE HTGQESYVWK MYQERCWDFF PAGDCFRKQY EDQLG
	Isoform 3 [UniParc]. Checksum: 637F449F56BDEB60	FASTA	3,859	435,934
	10 20 30 40 50 60 MAEGGEGGED EIQFLRTEDE VVLQCIATIH KEQRKFCLAA EGLGNRLCFL EPTSEAKYIP 70 80 90 100 110 120 PDLCVCNFVL EQSLSVRALQ EMLANTGENG GEGAAQGGGH RTLLYGHAVL LRHSFSGMYL 130 140 150 160 170 180 TCLTTSRSQT DKLAFDVGLR EHATGEACWW TIHPASKQRS EGEKVRIGDD LILVSVSSER 190 200 210 220 230 240 YLHLSVSNGN IQVDASFMQT LWNVHPTCSG SSIEEGYLLG GHVVRLFHGH DECLTIPSTD 250 260 270 280 290 300 QNDSQHRRIF YEAGGAGTRA RSLWRVEPLR ISWSGSNIRW GQAFRLRHLT TGHYLALTED 310 320 330 340 350 360 QGLILQDRAK SDTKSTAFSF RASKELKEKL DSSHKRDIEG MGVPEIKYGD SVCFVQHIAS 370 380 390 400 410 420 GLWVTYKAQD AKTSRLGPLK RKVILHQEGH MDDGLTLQRC QREESQAARI IRNTTALFSQ 430 440 450 460 470 480 FVSGNNRTAA PITLPIEEVL QTLQDLIAYF QPPEEEMRHE DKQNKLRSLK NRQNLFKEEG 490 500 510 520 530 540 MLALVLNCID RLNVYNSVAH FAGIAREESG MAWKEILNLL YKLLAALIRG NRNNCAQFSN 550 560 570 580 590 600 NLDWLISKLD RLESSSGILE VLHCILTESP EALNLIAEGH IKSIISLLDK HGRNHKVLDI 610 620 630 640 650 660 LCSLCLCNGV AVRANQNLIC DNLLPRRNLL LQTRLINDVT SIRPNIFLGV AEGSAQYKKW 670 680 690 700 710 720 YFELIIDQVD PFLTAEPTHL RVGWASSSGY APYPGGGEGW GGNGVGDDLY SYGFDGLHLW 730 740 750 760 770 780 SGRIPRAVAS INQHLLRSDD VVSCCLDLGV PSISFRINGQ PVQGMFENFN TDGLFFPVMS 790 800 810 820 830 840 FSAGVKVRFL MGGRHGEFKF LPPSGYAPCY EALLPKEKMR LEPVKEYKRD ADGIRDLLGT 850 860 870 880 890 900 TQFLSQASFI PCPVDTSQVI LPPHLEKIRD RLAENIHELW GMNKIELGWT FGKIRDDNKR 910 920 930 940 950 960 QHPCLVEFSK LPETEKNYNL QMSTETLKTL LALGCHIAHV NPAAEEDLKK VKLPKNYMMS 970 980 990 1000 1010 1020 NGYKPAPLDL SDVKLLPPQE ILVDKLAENA HNVWAKDRIK QGWTYGIQQD LKNKRNPRLV 1030 1040 1050 1060 1070 1080 PYALLDERTK KSNRDSLREA VRTFVGYGYN IEPSDQELAD SAVEKVSIDK IRFFRVERSY 1090 1100 1110 1120 1130 1140 AVRSGKWYFE FEVVTGGDMR VGWARPGCRP DVELGADDQA FVFEGNRGQR WHQGSGYFGR 1150 1160 1170 1180 1190 1200 TWQPGDVVGC MINLDDASMI FTLNGELLIT NKGSELAFAD YEIENGFVPI CCLGLSQIGR 1210 1220 1230 1240 1250 1260 MNLGTDASTF KFYTMCGLQE GFEPFAVNMN RDVAMWFSKR LPTFVNVPKD HPHIEVMRID 1270 1280 1290 1300 1310 1320 GTMDSPPCLK VTHKTFGTQN SNADMIYCRL SMPVECHSSF SHSPCLDSEA FQKRKQMQEI 1330 1340 1350 1360 1370 1380 LSHTTTQCYY AIRIFAGQDP SCVWVGWVTP DYHLYSEKFD LNKNCTVTVT LGDERGRVHE 1390 1400 1410 1420 1430 1440 SVKRSNCYMV WGGDIVASSQ RSNRSNVDLE IGCLVDLAMG MLSFSANGKE LGTCYQVEPN 1450 1460 1470 1480 1490 1500 TKVFPAVFLQ PTSTSLFQFE LGKLKNAMPL SAAIFRSEEK NPVPQCPPRL DVQTIQPVLW 1510 1520 1530 1540 1550 1560 SRMPNSFLKV ETERVSERHG WVVQCLEPLQ MMALHIPEEN RCVDILELCE QEDLMRFHYH 1570 1580 1590 1600 1610 1620 TLRLYSAVCA LGNSRVAYAL CSHVDLSQLF YAIDNKYLPG LLRSGFYDLL ISIHLASAKE 1630 1640 1650 1660 1670 1680 RKLMMKNEYI IPITSTTRNI RLFPDESKRH GLPGVGLRTC LKPGFRFSTP CFVVTGEDHQ 1690 1700 1710 1720 1730 1740 KQSPEIPLES LRTKALSMLT EAVQCSGAHI RDPVGGSVEF QFVPVLKLIG TLLVMGVFDD 1750 1760 1770 1780 1790 1800 DDVRQILLLI DPSVFGEHSA GTEEGAEKEE VTQVEEKAVE AGEKAGKEAP VKGLLQTRLP 1810 1820 1830 1840 1850 1860 ESVKLQMCEL LSYLCDCELQ HRVEAIVAFG DIYVSKLQAN QKFRYNELMQ ALNMSAALTA 1870 1880 1890 1900 1910 1920 RKTKEFRSPP QEQINMLLNF QLGENCPCPE EIREELYDFH EDLLLHCGVP LEEEEEEEED 1930 1940 1950 1960 1970 1980 TSWTGKLCAL VYKIKGPPKP EKEQPTEEEE RCPTTLKELI SQTMICWAQE DQIQDSELVR 1990 2000 2010 2020 2030 2040 MMFNLLRRQY DSIGELLQAL RKTYTISHTS VSDTINLLAA LGQIRSLLSV RMGKEEELLM 2050 2060 2070 2080 2090 2100 INGLGDIMNN KVFYQHPNLM RVLGMHETVM EVMVNVLGTE KSQIAFPKMV ASCCRFLCYF 2110 2120 2130 2140 2150 2160 CRISRQNQKA MFEHLSYLLE NSSVGLASPS MRGSTPLDVA ASSVMDNNEL ALSLEEPDLE 2170 2180 2190 2200 2210 2220 KVVTYLAGCG LQSCPMLLAK GYPDVGWNPI EGERYLSFLR FAVFVNSESV EENASVVVKL 2230 2240 2250 2260 2270 2280 LIRRPECFGP ALRGEGGNGL LAAMQGAIKI SENPALDLPS QGYKREVSTG DDEEEEEIVH 2290 2300 2310 2320 2330 2340 MGNAIMSFYS ALIDLLGRCA PEMHLIQTGK GEAIRIRSIL RSLVPTEDLV GIISIPLKLP 2350 2360 2370 2380 2390 2400 SLNKDGSVSE PDMAANFCPD HKAPMVLFLD RVYGIKDQTF LLHLLEVGFL PDLRASASLD 2410 2420 2430 2440 2450 2460 TVSLSTTEAA LALNRYICSA VLPLLTRCAP LFAGTEHCTS LIDSTLQTIY RLSKGRSLTK 2470 2480 2490 2500 2510 2520 AQRDTIEECL LAICNHLRPS MLQQLLRRLV FDVPQLNEYC KMPLKLLTNH YEQCWKYYCL 2530 2540 2550 2560 2570 2580 PSGWGSYGLA VEEELHLTEK LFWGIFDSLS HKKYDPDLFR MALPCLSAIA GALPPDYLDT 2590 2600 2610 2620 2630 2640 RITATLEKQI SVDADGNFDP KPINTMNFSL PEKLEYIVTK YAEHSHDKWA CDKSQSGWKY 2650 2660 2670 2680 2690 2700 GISLDENVKT HPLIRPFKTL TEKEKEIYRW PARESLKTML AVGWTVERTK EGEALVQQRE 2710 2720 2730 2740 2750 2760 NEKLRSVSQA NQGNSYSPAP LDLSNVVLSR ELQGMVEVVA ENYHNIWAKK KKLELESKGG 2770 2780 2790 2800 2810 2820 GSHPLLVPYD TLTAKEKFKD REKAQDLFKF LQVNGIIVSR GMKDMELDAS SMEKRFAYKF 2830 2840 2850 2860 2870 2880 LKKILKYVDS AQEFIAHLEA IVSSGKTEKS PRDQEIKFFA KVLLPLVDQY FTSHCLYFLS 2890 2900 2910 2920 2930 2940 SPLKPLSSSG YASHKEKEMV AGLFCKLAAL VRHRISLFGS DSTTMVSCLH ILAQTLDTRT 2950 2960 2970 2980 2990 3000 VMKSGSELVK AGLRAFFENA AEDLEKTSEN LKLGKFTHSR TQIKGVSQNI NYTTVALLPI 3010 3020 3030 3040 3050 3060 LTSIFEHVTQ HQFGMDLLLG DVQISCYHIL CSLYSLGTGK NIYVERQRPA LGECLASLAA 3070 3080 3090 3100 3110 3120 AIPVAFLEPT LNRYNPLSVF NTKTPRERSI LGMPDTVEDM CPDIPQLEGL MKEINDLAES 3130 3140 3150 3160 3170 3180 GARYTEMPHV IEVILPMLCN YLSYWWERGP ENLPPSTGPC CTKVTSEHLS LILGNILKII 3190 3200 3210 3220 3230 3240 NNNLGIDEAS WMKRIAVYAQ PIISKARPDL LRSHFIPTLE KLKKKAVKTV QEEEQLKADG 3250 3260 3270 3280 3290 3300 KGDTQEAELL ILDEFAVLCR DLYAFYPMLI RYVDNNRSNW LKSPDADSDQ LFRMVAEVFI 3310 3320 3330 3340 3350 3360 LWCKSHNFKR EEQNFVIQNE INNLAFLTGD SKSKMSKAMQ VKSGGQDQER KKTKRRGDLY 3370 3380 3390 3400 3410 3420 SIQTSLIVAA LKKMLPIGLN MCTPGDQELI SLAKSRYSHR DTDEEVREHL RNNLHLQEKS 3430 3440 3450 3460 3470 3480 DDPAVKWQLN LYKDVLKSEE PFNPEKTVER VQRISAAVFH LEQVEQPLRS KKAVWHKLLS 3490 3500 3510 3520 3530 3540 KQRKRAVVAC FRMAPLYNLP RHRSINLFLH GYQRFWIETE EYSFEEKLVQ DLAKSPKVEE 3550 3560 3570 3580 3590 3600 EEEEETEKQP DPLHQIILYF SRNALTERSK LEDDPLYTSY SSMMAKSCQS GEDEEEDEDK 3610 3620 3630 3640 3650 3660 EKTFEEKEME KQKTLYQQAR LHERGAAEMV LQMISASKGE MSPMVVETLK LGIAILNGGN 3670 3680 3690 3700 3710 3720 AGVQQKMLDY LKEKKDAGFF QSLSGLMQSC SVLDLNAFER QNKAEGLGMV TEEGTLIVRE 3730 3740 3750 3760 3770 3780 RGEKVLQNDE FTRDLFRFLQ LLCEGHNSDF QNFLRTQMGN TTTVNVIIST VDYLLRLQES 3790 3800 3810 3820 3830 3840 ISDFYWYYSG KDIIDESGQH NFSKALAVTK QIFNSLTEYI QGPCIGNQQS LAHSRLWDAV 3850 VGFLHVFANM QMKLSQGMW

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning and characterization of a human brain ryanodine receptor." Nakashima Y., Nishimura S., Maeda A., Barsoumian E.L., Hakamata Y., Nakai J., Allen P.D., Imoto K., Kita T. FEBS Lett. 417:157-162(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), TISSUE SPECIFICITY. Tissue: Brain.
[2]	"cDNA cloning and sequencing of the human ryanodine receptor type 3 (RYR3) reveals a novel alternative splice site in the RYR3 gene." Leeb T., Brenig B. FEBS Lett. 423:367-370(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), ALTERNATIVE SPLICING, VARIANTS SER-261; ILE-494; CYS-693; VAL-731; GLY-1380 AND SER-2268 DEL. Tissue: Fetal brain.
[3]	"Analysis of the DNA sequence and duplication history of human chromosome 15." Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K., Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N., Abouelleil A. , Arachchi H.M., Baradarani L., Birditt B., Bloom S., Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K., DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J., Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E., Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B., Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R., O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B., Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S., Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C. Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"Partial cloning and differential expression of ryanodine receptor/calcium-release channel genes in human tissues including the hippocampus and cerebellum." Martin C., Chapman K.E., Seckl J.R., Ashley R.H. Neuroscience 85:205-216(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 520-660, TISSUE SPECIFICITY. Tissue: Skeletal muscle.
[5]	"Involvement of the brain type of ryanodine receptor in T-cell proliferation." Hakamata Y., Nishimura S., Nakai J., Nakashima Y., Kita T., Imoto K. FEBS Lett. 352:206-210(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3943-4870. Tissue: T-cell.
[6]	"Localization of a novel ryanodine receptor gene (RYR3) to human chromosome 15q14-q15 by in situ hybridization." Sorrentino V., Giannini G., Malzac P., Mattei M.-G. Genomics 18:163-165(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 4644-4842. Tissue: Cervix carcinoma and Hepatoma.
[7]	"Isolation and partial cloning of ryanodine-sensitive Ca2+ release channel protein isoforms from human myometrial smooth muscle." Lynn S., Morgan J.M., Lamb H.K., Meissner G., Gillespie J.I. FEBS Lett. 372:6-12(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4652-4803. Tissue: Myometrium.
[8]	"Knock-down of the type 3 ryanodine receptor impairs sustained Ca2+ signaling via the T cell receptor/CD3 complex." Schwarzmann N., Kunerth S., Weber K., Mayr G.W., Guse A.H. J. Biol. Chem. 277:50636-50642(2002) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
[9]	"Characterization of the binding sites for the interactions between FKBP12 and intracellular calcium release channels." Wen H., Kang S., Song Y., Song Y., Yang H.J., Kim M.H., Park S. Arch. Biochem. Biophys. 517:37-42(2012) [PubMed] [Europe PMC] [Abstract] Cited for: INTERACTION WITH FKBP1A.
+	Additional computationally mapped references.

Web resources

Wikipedia

Ryanodine receptor entry

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB001025 mRNA. Translation: BAA23795.1. Frameshift.
AJ001515 mRNA. Translation: CAA04798.1.
AC010809 Genomic DNA. No translation available.
AC011938 Genomic DNA. No translation available.
AC055874 Genomic DNA. No translation available.
AC067793 Genomic DNA. No translation available.
AC087638 Genomic DNA. No translation available.
AJ002512 mRNA. Translation: CAA05503.1.
X74269 mRNA. Translation: CAA52326.1.
X74270 Genomic DNA. Translation: CAA52327.1.

IPI

IPI00217188.
IPI00329784.
IPI00893362.

PIR

S37537.
S66631.

RefSeq

NP_001027.3. NM_001036.3.
NP_001230925.1. NM_001243996.1.

UniGene

Hs.709373.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4ERV	X-ray	1.75	A	2597-2800	[»]

ProteinModelPortal

Q15413.

SMR

Q15413. Positions 13-530, 2598-2800, 3469-3495.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q15413. 2 interactions.

STRING

9606.ENSP00000373884.

PTM databases

PhosphoSite

Q15413.

Polymorphism databases

DMDM

18202506.

Proteomic databases

PaxDb

Q15413.

PRIDE

Q15413.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000389232; ENSP00000373884; ENSG00000198838.
ENST00000415757; ENSP00000399610; ENSG00000198838.

GeneID

6263.

KEGG

hsa:6263.

UCSC

uc001zhi.3. human.
uc010bar.3. human.

Organism-specific databases

CTD

6263.

GeneCards

GC15P033603.

H-InvDB

HIX0038065.

HGNC

HGNC:10485. RYR3.

HPA

CAB006887.

MIM

180903. gene.

neXtProt

NX_Q15413.

PharmGKB

PA34897.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG247670.

HOGENOM

HOG000231428.

HOVERGEN

HBG006699.

InParanoid

Q15413.

KO

K04963.

OMA

HSRTQIK.

OrthoDB

EOG4548XN.

Gene expression databases

Bgee

Q15413.

CleanEx

HS_RYR3.

Genevestigator

Q15413.

GermOnline

ENSG00000198838. Homo sapiens.

Family and domain databases

Gene3D

1.10.238.10. 1 hit.

InterPro

IPR001870. B30.2/SPRY.
IPR000699. Ca-rel_channel.
IPR008985. ConA-like_lec_gl_sf.
IPR011992. EF-hand-like_dom.
IPR002048. EF_hand_dom.
IPR014821. Ins145_P3_rcpt.
IPR005821. Ion_trans_dom.
IPR016093. MIR_motif.
IPR013662. RIH_assoc-dom.
IPR013333. Ryan_recept.
IPR003032. Ryanodine_rcpt.
IPR015925. Ryanodine_recept-rel.
IPR009460. Ryanrecept_TM4-6.
IPR018355. SPla/RYanodine_receptor_subgr.
IPR003877. SPRY_rcpt.
[Graphical view]

PANTHER

PTHR13715. PTHR13715. 1 hit.

Pfam

PF08709. Ins145_P3_rec. 1 hit.
PF00520. Ion_trans. 1 hit.
PF02815. MIR. 1 hit.
PF08454. RIH_assoc. 1 hit.
PF06459. RR_TM4-6. 1 hit.
PF01365. RYDR_ITPR. 2 hits.
PF02026. RyR. 4 hits.
PF00622. SPRY. 3 hits.
[Graphical view]

PRINTS

PR00795. RYANODINER.

SMART

SM00472. MIR. 4 hits.
SM00449. SPRY. 3 hits.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 3 hits.
SSF82109. MIR. 1 hit.

PROSITE

PS50188. B302_SPRY. 3 hits.
PS50919. MIR. 5 hits.
[Graphical view]

ProtoNet

Search...

Other

BindingDB

Q15413.

ChEMBL

CHEMBL2062.

GenomeRNAi

6263.

NextBio

24329.

SOURCE

Search...

Entry information

Entry name

RYR3_HUMAN

Accession

Primary (citable) accession number: Q15413
Secondary accession number(s): O15175, Q15412

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 26, 2001
Last sequence update:	March 8, 2011
Last modified:	May 1, 2013
This is version 131 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.