Reviewed,
UniProtKB/Swiss-Prot Q15404 (RSU1_HUMAN)
Last modified
July 7, 2009.
Version 73.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Ras suppressor protein 1 Short name=Rsu-1 Short name=RSP-1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 277 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro. |
| Sequence similarities | Contains 7 LRR (leucine-rich) repeats. |
Ontologies
| Keywords | |
|---|---|
| Domain | Leucine-rich repeat Repeat |
| Technical term | Complete proteome Direct protein sequencing |
| Gene Ontology (GO) | |
| Biological process | signal transduction Traceable author statement. Source: ProtInc |
| Molecular function | protein binding Inferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed Ref.8 | ||||||
| Chain | 2 – 277 | 276 | Ras suppressor protein 1 | PRO_0000097499 | |||||
Regions | |||||||||
| Repeat | 39 – 62 | 24 | LRR 1 | ||||||
| Repeat | 64 – 85 | 22 | LRR 2 | ||||||
| Repeat | 86 – 107 | 22 | LRR 3 | ||||||
| Repeat | 109 – 133 | 25 | LRR 4 | ||||||
| Repeat | 134 – 156 | 23 | LRR 5 | ||||||
| Repeat | 158 – 179 | 22 | LRR 6 | ||||||
| Repeat | 180 – 202 | 23 | LRR 7 | ||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10." Tsuda T., Cutler M.L. Genomics 18:461-462(1993) [PubMed: 8288261] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Skin. |
| [2] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Thalamus. |
| [3] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [4] | NHLBI resequencing and genotyping service (RS&G) Submitted (FEB-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [5] | "The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. Rogers J.Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [6] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain and Eye. |
| [8] | "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides." Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J. Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-13. Tissue: Platelet. |
| [9] | "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes." Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V. Biochem. J. 383:237-248(2004) [PubMed: 15242332] [Abstract] Cited for: PROTEIN SEQUENCE OF 138-155 AND 192-208. Tissue: Adipocyte. |
| [10] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| L12535 mRNA. Translation: AAA60292.1. AK312520 mRNA. Translation: BAG35419.1. CR536521 mRNA. Translation: CAG38758.1. CR541840 mRNA. Translation: CAG46639.1. EF445013 Genomic DNA. Translation: ACA06048.1. EF445013 Genomic DNA. Translation: ACA06049.1. EF445013 Genomic DNA. Translation: ACA06050.1. AL365215, AC073367 Genomic DNA. Translation: CAH73633.1. CH471072 Genomic DNA. Translation: EAW86222.1. BC005993 mRNA. Translation: AAH05993.1. BC008691 mRNA. Translation: AAH08691.1. BC015644 mRNA. Translation: AAH15644.1. | |
| IPI | IPI00017256. |
| PIR | I60122. |
| RefSeq | NP_036557.1. |
| UniGene | Hs.524161 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1D0B based on UniProtKB P25147. |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q15404. 2 interactions. |
2-D gel databases | |
| OGP | Q15404. |
Proteomic databases | |
| PRIDE | Q15404. |
Genome annotation databases | |
| Ensembl | ENSG00000148484. Homo sapiens. [Contig view] |
| GeneID | 6251. |
| KEGG | hsa:6251. |
| UCSC | uc001iok.1. human. |
Organism-specific databases | |
| GeneCards | GC10M016672. |
| H-InvDB | HIX0008679. |
| HGNC | HGNC:10464. RSU1. |
| MIM | 179555. gene. |
| PharmGKB | PA34876. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q15404. |
| HOVERGEN | Q15404. |
| OMA | Q15404. DMCDRGI. |
Gene expression databases | |
| ArrayExpress | Q15404. |
| Bgee | Q15404. |
| CleanEx | HS_RSU1. |
| GermOnline | ENSG00000148484. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001611. Leu-rich_rpt. IPR003591. Leu-rich_rpt_typical-subtyp. [Graphical view] |
| Pfam | PF00560. LRR_1. 7 hits. [Graphical view] |
| SMART | SM00369. LRR_TYP. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 24271. |
| SOURCE | Search... |
Entry information
| Entry name | RSU1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15404 Secondary accession number(s): Q6FI17 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 10 Human chromosome 10: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

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