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Protein

Ras suppressor protein 1

Gene

RSU1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.

GO - Biological processi

  • positive regulation of cell-substrate adhesion Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • signal transduction Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.
SignaLinkiQ15404.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras suppressor protein 1
Short name:
RSP-1
Short name:
Rsu-1
Gene namesi
Name:RSU1
Synonyms:RSP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:10464. RSU1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • focal adhesion Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34876.

Polymorphism and mutation databases

BioMutaiRSU1.
DMDMi2498866.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 277276Ras suppressor protein 1PRO_0000097499Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserineCombined sources

Keywords - PTMi

Acetylation

Proteomic databases

EPDiQ15404.
MaxQBiQ15404.
PaxDbiQ15404.
PeptideAtlasiQ15404.
PRIDEiQ15404.

2D gel databases

OGPiQ15404.

PTM databases

iPTMnetiQ15404.
PhosphoSiteiQ15404.

Expressioni

Gene expression databases

BgeeiENSG00000148484.
CleanExiHS_RSU1.
GenevisibleiQ15404. HS.

Organism-specific databases

HPAiHPA025927.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LIMS1P480594EBI-1057132,EBI-306928

Protein-protein interaction databases

BioGridi112164. 30 interactions.
IntActiQ15404. 8 interactions.
MINTiMINT-3031279.
STRINGi9606.ENSP00000339521.

Structurei

3D structure databases

ProteinModelPortaliQ15404.
SMRiQ15404. Positions 17-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati41 – 6323LRR 1Add
BLAST
Repeati64 – 8522LRR 2Add
BLAST
Repeati87 – 10923LRR 3Add
BLAST
Repeati110 – 13324LRR 4Add
BLAST
Repeati135 – 15622LRR 5Add
BLAST
Repeati158 – 17922LRR 6Add
BLAST
Repeati181 – 20222LRR 7Add
BLAST

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0617. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000116557.
HOVERGENiHBG002478.
InParanoidiQ15404.
OMAiLPGNFFM.
OrthoDBiEOG091G0JL6.
PhylomeDBiQ15404.
TreeFamiTF314790.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15404-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKSLKKLVE ESREKNQPEV DMSDRGISNM LDVNGLFTLS HITQLVLSHN
60 70 80 90 100
KLTMVPPNIA ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT
110 120 130 140 150
LPRGFGSLPA LEVLDLTYNN LSENSLPGNF FYLTTLRALY LSDNDFEILP
160 170 180 190 200
PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT QLKELHIQGN RLTVLPPELG
210 220 230 240 250
NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE TYKYLYGRHM
260 270
QANPEPPKKN NDKSKKISRK PLAAKNR
Length:277
Mass (Da):31,540
Last modified:January 23, 2007 - v3
Checksum:i6EDB2E033F417468
GO
Isoform 2 (identifier: Q15404-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-53: Missing.

Show »
Length:224
Mass (Da):25,545
Checksum:i1ACDF598D19296E1
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5353Missing in isoform 2. 1 PublicationVSP_043831Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12535 mRNA. Translation: AAA60292.1.
AK292911 mRNA. Translation: BAF85600.1.
AK312520 mRNA. Translation: BAG35419.1.
CR536521 mRNA. Translation: CAG38758.1.
CR541840 mRNA. Translation: CAG46639.1.
EF445013 Genomic DNA. Translation: ACA06048.1.
EF445013 Genomic DNA. Translation: ACA06049.1.
EF445013 Genomic DNA. Translation: ACA06050.1.
AL365215, AC073367 Genomic DNA. Translation: CAH73632.1.
AL365215, AC073367 Genomic DNA. Translation: CAH73633.1.
CH471072 Genomic DNA. Translation: EAW86222.1.
CH471072 Genomic DNA. Translation: EAW86223.1.
CH471072 Genomic DNA. Translation: EAW86224.1.
BC005993 mRNA. Translation: AAH05993.1.
BC008691 mRNA. Translation: AAH08691.1.
BC015644 mRNA. Translation: AAH15644.1.
CCDSiCCDS31157.1. [Q15404-2]
CCDS7112.1. [Q15404-1]
PIRiI60122.
RefSeqiNP_036557.1. NM_012425.3. [Q15404-1]
NP_689937.2. NM_152724.2. [Q15404-2]
UniGeneiHs.524161.

Genome annotation databases

EnsembliENST00000345264; ENSP00000339521; ENSG00000148484. [Q15404-1]
ENST00000377921; ENSP00000367154; ENSG00000148484. [Q15404-1]
ENST00000602389; ENSP00000473588; ENSG00000148484. [Q15404-2]
GeneIDi6251.
KEGGihsa:6251.
UCSCiuc001iok.4. human. [Q15404-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12535 mRNA. Translation: AAA60292.1.
AK292911 mRNA. Translation: BAF85600.1.
AK312520 mRNA. Translation: BAG35419.1.
CR536521 mRNA. Translation: CAG38758.1.
CR541840 mRNA. Translation: CAG46639.1.
EF445013 Genomic DNA. Translation: ACA06048.1.
EF445013 Genomic DNA. Translation: ACA06049.1.
EF445013 Genomic DNA. Translation: ACA06050.1.
AL365215, AC073367 Genomic DNA. Translation: CAH73632.1.
AL365215, AC073367 Genomic DNA. Translation: CAH73633.1.
CH471072 Genomic DNA. Translation: EAW86222.1.
CH471072 Genomic DNA. Translation: EAW86223.1.
CH471072 Genomic DNA. Translation: EAW86224.1.
BC005993 mRNA. Translation: AAH05993.1.
BC008691 mRNA. Translation: AAH08691.1.
BC015644 mRNA. Translation: AAH15644.1.
CCDSiCCDS31157.1. [Q15404-2]
CCDS7112.1. [Q15404-1]
PIRiI60122.
RefSeqiNP_036557.1. NM_012425.3. [Q15404-1]
NP_689937.2. NM_152724.2. [Q15404-2]
UniGeneiHs.524161.

3D structure databases

ProteinModelPortaliQ15404.
SMRiQ15404. Positions 17-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112164. 30 interactions.
IntActiQ15404. 8 interactions.
MINTiMINT-3031279.
STRINGi9606.ENSP00000339521.

PTM databases

iPTMnetiQ15404.
PhosphoSiteiQ15404.

Polymorphism and mutation databases

BioMutaiRSU1.
DMDMi2498866.

2D gel databases

OGPiQ15404.

Proteomic databases

EPDiQ15404.
MaxQBiQ15404.
PaxDbiQ15404.
PeptideAtlasiQ15404.
PRIDEiQ15404.

Protocols and materials databases

DNASUi6251.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000345264; ENSP00000339521; ENSG00000148484. [Q15404-1]
ENST00000377921; ENSP00000367154; ENSG00000148484. [Q15404-1]
ENST00000602389; ENSP00000473588; ENSG00000148484. [Q15404-2]
GeneIDi6251.
KEGGihsa:6251.
UCSCiuc001iok.4. human. [Q15404-1]

Organism-specific databases

CTDi6251.
GeneCardsiRSU1.
HGNCiHGNC:10464. RSU1.
HPAiHPA025927.
MIMi179555. gene.
neXtProtiNX_Q15404.
PharmGKBiPA34876.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0617. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00840000129686.
HOGENOMiHOG000116557.
HOVERGENiHBG002478.
InParanoidiQ15404.
OMAiLPGNFFM.
OrthoDBiEOG091G0JL6.
PhylomeDBiQ15404.
TreeFamiTF314790.

Enzyme and pathway databases

ReactomeiR-HSA-446388. Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.
SignaLinkiQ15404.

Miscellaneous databases

ChiTaRSiRSU1. human.
GeneWikiiRSU1.
GenomeRNAii6251.
PROiQ15404.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000148484.
CleanExiHS_RSU1.
GenevisibleiQ15404. HS.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF13855. LRR_8. 2 hits.
[Graphical view]
SMARTiSM00369. LRR_TYP. 7 hits.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSU1_HUMAN
AccessioniPrimary (citable) accession number: Q15404
Secondary accession number(s): A8KA46, D3DRU3, Q6FI17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 7, 2016
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.