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Reviewed, UniProtKB/Swiss-Prot Q15404 (RSU1_HUMAN)

Last modified November 25, 2008. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Ras suppressor protein 1
      Short name=Rsu-1
      Short name=RSP-1
Gene names
Name: RSU1
Synonyms: RSP1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length277 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

General annotation (Comments)

Function

Potentially plays a role in the Ras signal transduction pathway. Capable of suppressing v-Ras transformation in vitro.

Sequence similarities

Contains 7 LRR (leucine-rich) repeats.

Ontologies

Keywords

   DomainLeucine-rich repeat
Repeat
   Technical termDirect protein sequencing

Gene Ontology (GO)

   Biological processsignal transduction

Traceable author statement. Source: ProtInc

   Molecular functionprotein binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed
Chain2 – 277276Ras suppressor protein 1
PRO_0000097499

Regions

Repeat39 – 6224LRR 1
Repeat64 – 8522LRR 2
Repeat86 – 10722LRR 3
Repeat109 – 13325LRR 4
Repeat134 – 15623LRR 5
Repeat158 – 17922LRR 6
Repeat180 – 20223LRR 7

Sequences

Sequence LengthMass (Da)Tools
Q15404-1 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: 6EDB2E033F417468

FASTA27731,540
        10         20         30         40         50         60 
MSKSLKKLVE ESREKNQPEV DMSDRGISNM LDVNGLFTLS HITQLVLSHN KLTMVPPNIA 

        70         80         90        100        110        120 
ELKNLEVLNF FNNQIEELPT QISSLQKLKH LNLGMNRLNT LPRGFGSLPA LEVLDLTYNN 

       130        140        150        160        170        180 
LSENSLPGNF FYLTTLRALY LSDNDFEILP PDIGKLTKLQ ILSLRDNDLI SLPKEIGELT 

       190        200        210        220        230        240 
QLKELHIQGN RLTVLPPELG NLDLTGQKQV FKAENNPWVT PIADQFQLGV SHVFEYIRSE 

       250        260        270 
TYKYLYGRHM QANPEPPKKN NDKSKKISRK PLAAKNR 

« Hide

References

« Hide 'large scale' references
[1]"Human RSU1 is highly homologous to mouse Rsu-1 and localizes to human chromosome 10."
Tsuda T., Cutler M.L.
Genomics 18:461-462(1993) [PubMed: 8288261] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skin.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Eye.
[3]"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K., Goethals M., Martens L., Van Damme J., Staes A., Thomas G.R., Vandekerckhove J.
Nat. Biotechnol. 21:566-569(2003) [PubMed: 12665801] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-13.
Tissue: Platelet.
[4]"Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
Biochem. J. 383:237-248(2004) [PubMed: 15242332] [Abstract]
Cited for: PROTEIN SEQUENCE OF 138-155 AND 192-208.
Tissue: Adipocyte.
+Additional computationally mapped references.

Cross-references

Sequence databases

L12535 mRNA. Translation: AAA60292.1.
BC005993 mRNA. Translation: AAH05993.1.
BC008691 mRNA. Translation: AAH08691.1.
BC015644 mRNA. Translation: AAH15644.1.
PIRI60122.
RefSeqNP_036557.1.
UniGeneHs.524161

3D structure databases

HSSPHSSP built from PDB template 1D0B based on UniProtKB P25147.
ModBaseSearch...

PTM databases

PhosphoSiteQ15404.

2-D gel databases

OGPQ15404.

Genome annotation databases

EnsemblENSG00000148484. Homo sapiens. [Contig view]
GeneID6251.
KEGGhsa:6251.

Organism-specific databases

H-InvDBHIX0008679.
HGNCHGNC:10464. RSU1.
MIM179555. gene.
PharmGKBPA34876.
GenAtlasSearch...
GeneCardsSearch...

Phylogenomic databases

HOGENOMQ15404.
HOVERGENQ15404.

Gene expression databases

ArrayExpressQ15404.
CleanExHS_RSU1.
GermOnlineENSG00000148484. Homo sapiens.

Family and domain databases

InterProIPR001611. LRR.
IPR003591. LRR_sub-typ.
[Graphical view]
PfamPF00560. LRR_1. 7 hits.
[Graphical view]
PRINTSPR00019. LEURICHRPT.
SMARTSM00369. LRR_TYP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

LinkHubQ15404.
NextBio24271.
SOURCESearch...

Entry information

Entry nameRSU1_HUMAN
AccessionPrimary (citable) accession number: Q15404
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 25, 2008
This is version 65 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 10

Human chromosome 10: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents