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Q15399

- TLR1_HUMAN

UniProt

Q15399 - TLR1_HUMAN

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Protein

Toll-like receptor 1

Gene

TLR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity).By similarity

GO - Molecular functioni

  1. protein heterodimerization activity Source: MGI
  2. receptor activity Source: ProtInc
  3. transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  1. cellular response to triacyl bacterial lipopeptide Source: MGI
  2. detection of triacyl bacterial lipopeptide Source: MGI
  3. immune response Source: ProtInc
  4. inflammatory response Source: UniProtKB-KW
  5. innate immune response Source: UniProtKB-KW
  6. macrophage activation Source: UniProtKB
  7. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
  8. positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
  9. positive regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
  10. regulation of cytokine secretion Source: InterPro
  11. signal transduction Source: ProtInc
  12. toll-like receptor 1 signaling pathway Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 1
Alternative name(s):
Toll/interleukin-1 receptor-like protein
Short name:
TIL
CD_antigen: CD281
Gene namesi
Name:TLR1
Synonyms:KIAA0012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:11847. TLR1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 580556ExtracellularSequence AnalysisAdd
BLAST
Transmembranei581 – 60121HelicalSequence AnalysisAdd
BLAST
Topological domaini602 – 786185CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cytoplasmic vesicle Source: UniProtKB-KW
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: UniProtKB
  4. plasma membrane Source: ProtInc
  5. Toll-like receptor 1-Toll-like receptor 2 protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Membrane

Pathology & Biotechi

Organism-specific databases

MIMi613223. phenotype.
PharmGKBiPA36549.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 24241 PublicationAdd
BLAST
Chaini25 – 786762Toll-like receptor 1PRO_0000034705Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi51 – 511N-linked (GlcNAc...)1 Publication
Disulfide bondi110 ↔ 1321 Publication
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
Glycosylationi163 – 1631N-linked (GlcNAc...)2 Publications
Disulfide bondi223 ↔ 2301 Publication
Glycosylationi330 – 3301N-linked (GlcNAc...)1 Publication
Disulfide bondi343 ↔ 3681 Publication
Disulfide bondi419 ↔ 4421 Publication
Glycosylationi429 – 4291N-linked (GlcNAc...)1 Publication
Glycosylationi578 – 5781N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15399.
PRIDEiQ15399.

PTM databases

PhosphoSiteiQ15399.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

Gene expression databases

BgeeiQ15399.
CleanExiHS_TLR1.
ExpressionAtlasiQ15399. baseline and differential.
GenevestigatoriQ15399.

Interactioni

Subunit structurei

Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity). Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.By similarity1 Publication

Protein-protein interaction databases

BioGridi112951. 2 interactions.
STRINGi9606.ENSP00000354932.

Structurei

Secondary structure

1
786
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi28 – 303Combined sources
Beta strandi48 – 514Combined sources
Helixi62 – 654Combined sources
Beta strandi73 – 753Combined sources
Beta strandi83 – 853Combined sources
Helixi86 – 894Combined sources
Beta strandi97 – 993Combined sources
Beta strandi107 – 1093Combined sources
Beta strandi117 – 1204Combined sources
Helixi133 – 1375Combined sources
Beta strandi143 – 1508Combined sources
Helixi153 – 1597Combined sources
Beta strandi164 – 1718Combined sources
Helixi181 – 1844Combined sources
Beta strandi189 – 1957Combined sources
Beta strandi198 – 2003Combined sources
Beta strandi214 – 2185Combined sources
Beta strandi221 – 2233Combined sources
Turni227 – 2304Combined sources
Helixi231 – 2388Combined sources
Helixi239 – 2424Combined sources
Beta strandi248 – 25710Combined sources
Helixi258 – 26912Combined sources
Beta strandi274 – 28512Combined sources
Beta strandi301 – 3099Combined sources
Helixi317 – 3248Combined sources
Beta strandi329 – 3368Combined sources
Beta strandi352 – 3543Combined sources
Turni362 – 3676Combined sources
Beta strandi376 – 3783Combined sources
Helixi387 – 3948Combined sources
Beta strandi402 – 4043Combined sources
Helixi414 – 4163Combined sources
Beta strandi427 – 4293Combined sources
Helixi437 – 4415Combined sources
Beta strandi449 – 4513Combined sources
Helixi462 – 4665Combined sources
Beta strandi472 – 4743Combined sources
Beta strandi631 – 6333Combined sources
Beta strandi637 – 6426Combined sources
Helixi645 – 6473Combined sources
Helixi648 – 6536Combined sources
Helixi655 – 6606Combined sources
Turni661 – 6633Combined sources
Turni669 – 6724Combined sources
Helixi679 – 68911Combined sources
Beta strandi690 – 6989Combined sources
Helixi699 – 7046Combined sources
Helixi707 – 7126Combined sources
Beta strandi724 – 7329Combined sources
Helixi736 – 7383Combined sources
Helixi744 – 7518Combined sources
Helixi762 – 7643Combined sources
Helixi767 – 77711Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1FYVX-ray2.90A625-785[»]
2Z7XX-ray2.10B25-475[»]
ProteinModelPortaliQ15399.
SMRiQ15399. Positions 25-578, 625-785.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15399.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati54 – 7724LRR 1Add
BLAST
Repeati78 – 10124LRR 2Add
BLAST
Repeati102 – 12524LRR 3Add
BLAST
Repeati126 – 15025LRR 4Add
BLAST
Repeati151 – 17525LRR 5Add
BLAST
Repeati176 – 19924LRR 6Add
BLAST
Repeati200 – 22324LRR 7Add
BLAST
Repeati224 – 25027LRR 8Add
BLAST
Repeati251 – 27828LRR 9Add
BLAST
Repeati279 – 30830LRR 10Add
BLAST
Repeati309 – 33729LRR 11Add
BLAST
Repeati338 – 36124LRR 12Add
BLAST
Repeati362 – 38827LRR 13Add
BLAST
Repeati389 – 41426LRR 14Add
BLAST
Repeati415 – 43723LRR 15Add
BLAST
Repeati438 – 45720LRR 16Add
BLAST
Repeati458 – 47821LRR 17Add
BLAST
Repeati479 – 50022LRR 18Add
BLAST
Repeati501 – 52424LRR 19Add
BLAST
Domaini525 – 57955LRRCTAdd
BLAST
Domaini635 – 779145TIRPROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni313 – 3164Interaction with bacterial lipopeptide

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG272762.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ15399.
KOiK05398.
OMAiKEFGNMS.
OrthoDBiEOG7GN2M5.
PhylomeDBiQ15399.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027190. TLR1.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF261. PTHR24365:SF261. 1 hit.
PfamiPF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15399-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTSIFHFAII FMLILQIRIQ LSEESEFLVD RSKNGLIHVP KDLSQKTTIL
60 70 80 90 100
NISQNYISEL WTSDILSLSK LRILIISHNR IQYLDISVFK FNQELEYLDL
110 120 130 140 150
SHNKLVKISC HPTVNLKHLD LSFNAFDALP ICKEFGNMSQ LKFLGLSTTH
160 170 180 190 200
LEKSSVLPIA HLNISKVLLV LGETYGEKED PEGLQDFNTE SLHIVFPTNK
210 220 230 240 250
EFHFILDVSV KTVANLELSN IKCVLEDNKC SYFLSILAKL QTNPKLSNLT
260 270 280 290 300
LNNIETTWNS FIRILQLVWH TTVWYFSISN VKLQGQLDFR DFDYSGTSLK
310 320 330 340 350
ALSIHQVVSD VFGFPQSYIY EIFSNMNIKN FTVSGTRMVH MLCPSKISPF
360 370 380 390 400
LHLDFSNNLL TDTVFENCGH LTELETLILQ MNQLKELSKI AEMTTQMKSL
410 420 430 440 450
QQLDISQNSV SYDEKKGDCS WTKSLLSLNM SSNILTDTIF RCLPPRIKVL
460 470 480 490 500
DLHSNKIKSI PKQVVKLEAL QELNVAFNSL TDLPGCGSFS SLSVLIIDHN
510 520 530 540 550
SVSHPSADFF QSCQKMRSIK AGDNPFQCTC ELGEFVKNID QVSSEVLEGW
560 570 580 590 600
PDSYKCDYPE SYRGTLLKDF HMSELSCNIT LLIVTIVATM LVLAVTVTSL
610 620 630 640 650
CSYLDLPWYL RMVCQWTQTR RRARNIPLEE LQRNLQFHAF ISYSGHDSFW
660 670 680 690 700
VKNELLPNLE KEGMQICLHE RNFVPGKSIV ENIITCIEKS YKSIFVLSPN
710 720 730 740 750
FVQSEWCHYE LYFAHHNLFH EGSNSLILIL LEPIPQYSIP SSYHKLKSLM
760 770 780
ARRTYLEWPK EKSKRGLFWA NLRAAINIKL TEQAKK
Length:786
Mass (Da):90,291
Last modified:May 1, 2007 - v3
Checksum:i1BFCCC5E42EA5242
GO

Sequence cautioni

The sequence BAA02801.2 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti182 – 1821E → G in CAB43364. (PubMed:11230166)Curated
Sequence conflicti228 – 2281N → S in CAB43364. (PubMed:11230166)Curated
Sequence conflicti276 – 2761F → S in CAB43364. (PubMed:11230166)Curated

Polymorphismi

Genetic variations in TLR1 may influence susceptibility to or protection against contracting leprosy and define the leprosy susceptibility locus 5 [MIMi:613223]. Ser-602 is a common allele in Caucasians. It is associated with impaired cell surface expression and receptor function resulting in protection against leprosy.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti44 – 441S → P.1 Publication
Corresponds to variant rs76600635 [ dbSNP | Ensembl ].
VAR_066340
Natural varianti75 – 751I → T.1 Publication
Corresponds to variant rs137853170 [ dbSNP | Ensembl ].
VAR_066341
Natural varianti80 – 801R → T.3 Publications
Corresponds to variant rs5743611 [ dbSNP | Ensembl ].
VAR_031916
Natural varianti118 – 1181H → Y.1 Publication
Corresponds to variant rs5743612 [ dbSNP | Ensembl ].
VAR_018474
Natural varianti248 – 2481N → S May confer susceptibility to leprosy. 4 Publications
Corresponds to variant rs4833095 [ dbSNP | Ensembl ].
VAR_031917
Natural varianti305 – 3051H → L.1 Publication
Corresponds to variant rs3923647 [ dbSNP | Ensembl ].
VAR_031918
Natural varianti315 – 3151P → L Severe impairment of activity. 1 Publication
Corresponds to variant rs5743613 [ dbSNP | Ensembl ].
VAR_031919
Natural varianti352 – 3521H → N.1 Publication
Corresponds to variant rs76796448 [ dbSNP | Ensembl ].
VAR_066342
Natural varianti460 – 4601I → V.1 Publication
Corresponds to variant rs137853171 [ dbSNP | Ensembl ].
VAR_066343
Natural varianti542 – 5421V → A.1 Publication
Corresponds to variant rs137853172 [ dbSNP | Ensembl ].
VAR_066344
Natural varianti554 – 5541Y → C Severe impairment of activity. 1 Publication
VAR_066345
Natural varianti587 – 5871V → G.1 Publication
Corresponds to variant rs5743617 [ dbSNP | Ensembl ].
VAR_031920
Natural varianti602 – 6021S → I Severe impairment of activity. 5 Publications
Corresponds to variant rs5743618 [ dbSNP | Ensembl ].
VAR_031921
Natural varianti631 – 6311L → R.
Corresponds to variant rs5743619 [ dbSNP | Ensembl ].
VAR_052358
Natural varianti651 – 6511V → A Severe impairment of activity. 1 Publication
VAR_066346
Natural varianti674 – 6741V → A.1 Publication
VAR_066347
Natural varianti720 – 7201H → P Severe impairment of activity. 1 Publication
Corresponds to variant rs113706342 [ dbSNP | Ensembl ].
VAR_066348
Natural varianti733 – 7331P → L.1 Publication
Corresponds to variant rs5743621 [ dbSNP | Ensembl ].
VAR_052359

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88540 mRNA. Translation: AAC34137.1.
AB445617 mRNA. Translation: BAG55014.1.
DQ012259 mRNA. Translation: AAY85638.1.
DQ012260 mRNA. Translation: AAY85639.1.
DQ012261 mRNA. Translation: AAY85640.1.
D13637 mRNA. Translation: BAA02801.2. Different initiation.
AL050262 mRNA. Translation: CAB43364.1.
BC109093 mRNA. Translation: AAI09094.1.
BC109094 mRNA. Translation: AAI09095.1.
CCDSiCCDS33973.1.
PIRiT08664.
RefSeqiNP_003254.2. NM_003263.3.
XP_005262719.1. XM_005262662.2.
XP_005262720.1. XM_005262663.2.
XP_005262722.1. XM_005262665.2.
XP_005262723.1. XM_005262666.2.
XP_006714091.1. XM_006714028.1.
UniGeneiHs.621817.
Hs.654532.

Genome annotation databases

EnsembliENST00000308979; ENSP00000354932; ENSG00000174125.
ENST00000502213; ENSP00000421259; ENSG00000174125.
GeneIDi7096.
KEGGihsa:7096.
UCSCiuc003gtl.3. human.

Polymorphism databases

DMDMi146291086.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88540 mRNA. Translation: AAC34137.1 .
AB445617 mRNA. Translation: BAG55014.1 .
DQ012259 mRNA. Translation: AAY85638.1 .
DQ012260 mRNA. Translation: AAY85639.1 .
DQ012261 mRNA. Translation: AAY85640.1 .
D13637 mRNA. Translation: BAA02801.2 . Different initiation.
AL050262 mRNA. Translation: CAB43364.1 .
BC109093 mRNA. Translation: AAI09094.1 .
BC109094 mRNA. Translation: AAI09095.1 .
CCDSi CCDS33973.1.
PIRi T08664.
RefSeqi NP_003254.2. NM_003263.3.
XP_005262719.1. XM_005262662.2.
XP_005262720.1. XM_005262663.2.
XP_005262722.1. XM_005262665.2.
XP_005262723.1. XM_005262666.2.
XP_006714091.1. XM_006714028.1.
UniGenei Hs.621817.
Hs.654532.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1FYV X-ray 2.90 A 625-785 [» ]
2Z7X X-ray 2.10 B 25-475 [» ]
ProteinModelPortali Q15399.
SMRi Q15399. Positions 25-578, 625-785.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112951. 2 interactions.
STRINGi 9606.ENSP00000354932.

PTM databases

PhosphoSitei Q15399.

Polymorphism databases

DMDMi 146291086.

Proteomic databases

PaxDbi Q15399.
PRIDEi Q15399.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000308979 ; ENSP00000354932 ; ENSG00000174125 .
ENST00000502213 ; ENSP00000421259 ; ENSG00000174125 .
GeneIDi 7096.
KEGGi hsa:7096.
UCSCi uc003gtl.3. human.

Organism-specific databases

CTDi 7096.
GeneCardsi GC04M038797.
HGNCi HGNC:11847. TLR1.
MIMi 601194. gene.
613223. phenotype.
neXtProti NX_Q15399.
PharmGKBi PA36549.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG272762.
GeneTreei ENSGT00760000119006.
HOGENOMi HOG000008676.
HOVERGENi HBG023180.
InParanoidi Q15399.
KOi K05398.
OMAi KEFGNMS.
OrthoDBi EOG7GN2M5.
PhylomeDBi Q15399.
TreeFami TF351113.

Miscellaneous databases

EvolutionaryTracei Q15399.
GeneWikii TLR_1.
GenomeRNAii 7096.
NextBioi 27759.
PROi Q15399.
SOURCEi Search...

Gene expression databases

Bgeei Q15399.
CleanExi HS_TLR1.
ExpressionAtlasi Q15399. baseline and differential.
Genevestigatori Q15399.

Family and domain databases

Gene3Di 3.40.50.10140. 1 hit.
InterProi IPR000483. Cys-rich_flank_reg_C.
IPR001611. Leu-rich_rpt.
IPR000157. TIR_dom.
IPR027190. TLR1.
IPR017241. Toll-like_receptor.
[Graphical view ]
PANTHERi PTHR24365:SF261. PTHR24365:SF261. 1 hit.
Pfami PF13855. LRR_8. 2 hits.
PF01582. TIR. 1 hit.
[Graphical view ]
PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
SMARTi SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view ]
SUPFAMi SSF52200. SSF52200. 1 hit.
PROSITEi PS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A family of human receptors structurally related to Drosophila Toll."
    Rock F.L., Hardiman G., Timans J.C., Kastelein R.A., Bazan J.F.
    Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-248 AND ILE-602.
    Tissue: Erythroleukemia.
  2. "Natural selection in the TLR-related genes in the course of primate evolution."
    Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
    Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
    Georgel P., Macquin C., Bahram S.
    PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-80 AND ILE-602.
  4. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-80.
    Tissue: Bone marrow.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-248 AND ILE-602.
    Tissue: Brain.
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-248 AND ILE-602.
  7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
    Zhang Z., Henzel W.J.
    Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 25-39.
  8. "Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy."
    Johnson C.M., Lyle E.A., Omueti K.O., Stepensky V.A., Yegin O., Alpsoy E., Hamann L., Schumann R.R., Tapping R.I.
    J. Immunol. 178:7520-7524(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN PROTECTION AGAINST LEPROSY.
  9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-163.
    Tissue: Liver.
  10. "Structural basis for signal transduction by the Toll/interleukin-1 receptor domains."
    Xu Y., Tao X., Shen B., Horng T., Medzhitov R., Manley J.L., Tong L.
    Nature 408:111-115(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 625-785.
  11. "Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide."
    Jin M.S., Kim S.E., Heo J.Y., Lee M.E., Kim H.M., Paik S.-G., Lee H., Lee J.-O.
    Cell 130:1071-1082(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 25-476 IN COMPLEX WITH TLR1 AND BACTERIAL LIPOPEPTIDE ANALOG, DISULFIDE BONDS, GLYCOSYLATION AT ASN-51; ASN-163; ASN-330 AND ASN-429.
  12. "Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions."
    Schuring R.P., Hamann L., Faber W.R., Pahan D., Richardus J.H., Schumann R.R., Oskam L.
    J. Infect. Dis. 199:1816-1819(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION OF VARIANT SER-248 WITH SUSCEPTIBILITY TO LEPROSY.
  13. "Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."
    Ben-Ali M., Corre B., Manry J., Barreiro L.B., Quach H., Boniotto M., Pellegrini S., Quintana-Murci L.
    Hum. Mutat. 32:643-652(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS PRO-44; THR-75; THR-80; TYR-118; SER-248; LEU-305; LEU-315; ASN-352; VAL-460; ALA-542; CYS-554; GLY-587; ILE-602; ALA-651; ALA-674; PRO-720 AND LEU-733, CHARACTERIZATION OF VARIANTS LEU-315; CYS-554; ILE-602; ALA-651 AND PRO-720.

Entry informationi

Entry nameiTLR1_HUMAN
AccessioniPrimary (citable) accession number: Q15399
Secondary accession number(s): D1CS39
, D1CS41, O15452, Q32MK3, Q32MK4, Q9UG90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2007
Last modified: November 26, 2014
This is version 155 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3