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Protein

Toll-like receptor 1

Gene

TLR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Forms the activation cluster TLR2:TLR1:CD14 in response to triacylated lipopeptides, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.1 Publication

GO - Molecular functioni

  • lipopeptide binding Source: GO_Central
  • protein heterodimerization activity Source: MGI
  • receptor activity Source: ProtInc
  • Toll-like receptor 2 binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  • cellular response to triacyl bacterial lipopeptide Source: UniProtKB
  • defense response to bacterium Source: GO_Central
  • detection of triacyl bacterial lipopeptide Source: MGI
  • immune response Source: ProtInc
  • inflammatory response Source: UniProtKB-KW
  • innate immune response Source: UniProtKB-KW
  • macrophage activation Source: UniProtKB
  • MyD88-dependent toll-like receptor signaling pathway Source: Reactome
  • positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
  • positive regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
  • regulation of cytokine secretion Source: InterPro
  • signal transduction Source: ProtInc
  • toll-like receptor 1 signaling pathway Source: InterPro
  • toll-like receptor signaling pathway Source: GO_Central
  • toll-like receptor TLR1:TLR2 signaling pathway Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity, Inflammatory response, Innate immunity

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174125-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1461957. Beta defensins.
R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168179. Toll Like Receptor TLR1:TLR2 Cascade.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).
R-HSA-5686938. Regulation of TLR by endogenous ligand.
SIGNORiQ15399.

Names & Taxonomyi

Protein namesi
Recommended name:
Toll-like receptor 1
Alternative name(s):
Toll/interleukin-1 receptor-like protein
Short name:
TIL
CD_antigen: CD281
Gene namesi
Name:TLR1
Synonyms:KIAA0012
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:11847. TLR1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 580ExtracellularSequence analysisAdd BLAST556
Transmembranei581 – 601HelicalSequence analysisAdd BLAST21
Topological domaini602 – 786CytoplasmicSequence analysisAdd BLAST185

GO - Cellular componenti

  • Golgi apparatus Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: UniProtKB
  • membrane raft Source: UniProtKB
  • phagocytic vesicle membrane Source: UniProtKB-SubCell
  • plasma membrane Source: Reactome
  • Toll-like receptor 1-Toll-like receptor 2 protein complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7096.
MalaCardsiTLR1.
MIMi613223. phenotype.
OpenTargetsiENSG00000174125.
PharmGKBiPA36549.

Polymorphism and mutation databases

BioMutaiTLR1.
DMDMi146291086.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 241 PublicationAdd BLAST24
ChainiPRO_000003470525 – 786Toll-like receptor 1Add BLAST762

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi51N-linked (GlcNAc...)1 Publication1
Disulfide bondi110 ↔ 1321 Publication
Glycosylationi137N-linked (GlcNAc...)Sequence analysis1
Glycosylationi163N-linked (GlcNAc...)2 Publications1
Disulfide bondi223 ↔ 2301 Publication
Glycosylationi330N-linked (GlcNAc...)1 Publication1
Disulfide bondi343 ↔ 3681 Publication
Disulfide bondi419 ↔ 4421 Publication
Glycosylationi429N-linked (GlcNAc...)1 Publication1
Glycosylationi578N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15399.
PaxDbiQ15399.
PeptideAtlasiQ15399.
PRIDEiQ15399.

PTM databases

iPTMnetiQ15399.
PhosphoSitePlusiQ15399.

Expressioni

Tissue specificityi

Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

Gene expression databases

BgeeiENSG00000174125.
CleanExiHS_TLR1.
ExpressionAtlasiQ15399. baseline and differential.
GenevisibleiQ15399. HS.

Interactioni

Subunit structurei

Interacts (via extracellular domain) with TLR2. TLR2 seems to exist in heterodimers with either TLR1 or TLR6 before stimulation by the ligand. The heterodimers form bigger oligomers in response to their corresponding ligands as well as further heterotypic associations with other receptors such as CD14 and/or CD36 (PubMed:16880211, PubMed:17889651). Binds MYD88 (via TIR domain). Interacts with CNPY3 (By similarity).By similarity2 Publications

GO - Molecular functioni

  • protein heterodimerization activity Source: MGI
  • Toll-like receptor 2 binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112951. 10 interactors.
STRINGi9606.ENSP00000354932.

Structurei

Secondary structure

1786
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi28 – 30Combined sources3
Beta strandi48 – 51Combined sources4
Helixi62 – 65Combined sources4
Beta strandi73 – 75Combined sources3
Beta strandi83 – 85Combined sources3
Helixi86 – 89Combined sources4
Beta strandi97 – 99Combined sources3
Beta strandi107 – 109Combined sources3
Beta strandi117 – 120Combined sources4
Helixi133 – 137Combined sources5
Beta strandi143 – 150Combined sources8
Helixi153 – 159Combined sources7
Beta strandi164 – 171Combined sources8
Helixi181 – 184Combined sources4
Beta strandi189 – 195Combined sources7
Beta strandi198 – 200Combined sources3
Beta strandi214 – 218Combined sources5
Beta strandi221 – 223Combined sources3
Turni227 – 230Combined sources4
Helixi231 – 238Combined sources8
Helixi239 – 242Combined sources4
Beta strandi248 – 257Combined sources10
Helixi258 – 269Combined sources12
Beta strandi274 – 285Combined sources12
Beta strandi301 – 309Combined sources9
Helixi317 – 324Combined sources8
Beta strandi329 – 336Combined sources8
Beta strandi352 – 354Combined sources3
Turni362 – 367Combined sources6
Beta strandi376 – 378Combined sources3
Helixi387 – 394Combined sources8
Beta strandi402 – 404Combined sources3
Helixi414 – 416Combined sources3
Beta strandi427 – 429Combined sources3
Helixi437 – 441Combined sources5
Beta strandi449 – 451Combined sources3
Helixi462 – 466Combined sources5
Beta strandi472 – 474Combined sources3
Beta strandi631 – 633Combined sources3
Beta strandi637 – 642Combined sources6
Helixi645 – 647Combined sources3
Helixi648 – 653Combined sources6
Helixi655 – 660Combined sources6
Turni661 – 663Combined sources3
Turni669 – 672Combined sources4
Helixi679 – 689Combined sources11
Beta strandi690 – 698Combined sources9
Helixi699 – 704Combined sources6
Helixi707 – 712Combined sources6
Beta strandi724 – 732Combined sources9
Helixi736 – 738Combined sources3
Helixi744 – 751Combined sources8
Helixi762 – 764Combined sources3
Helixi767 – 777Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FYVX-ray2.90A625-785[»]
2Z7XX-ray2.10B25-475[»]
ProteinModelPortaliQ15399.
SMRiQ15399.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15399.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati54 – 77LRR 1Add BLAST24
Repeati78 – 101LRR 2Add BLAST24
Repeati102 – 125LRR 3Add BLAST24
Repeati126 – 150LRR 4Add BLAST25
Repeati151 – 175LRR 5Add BLAST25
Repeati176 – 199LRR 6Add BLAST24
Repeati200 – 223LRR 7Add BLAST24
Repeati224 – 250LRR 8Add BLAST27
Repeati251 – 278LRR 9Add BLAST28
Repeati279 – 308LRR 10Add BLAST30
Repeati309 – 337LRR 11Add BLAST29
Repeati338 – 361LRR 12Add BLAST24
Repeati362 – 388LRR 13Add BLAST27
Repeati389 – 414LRR 14Add BLAST26
Repeati415 – 437LRR 15Add BLAST23
Repeati438 – 457LRR 16Add BLAST20
Repeati458 – 478LRR 17Add BLAST21
Repeati479 – 500LRR 18Add BLAST22
Repeati501 – 524LRR 19Add BLAST24
Domaini525 – 579LRRCTAdd BLAST55
Domaini635 – 779TIRPROSITE-ProRule annotationAdd BLAST145

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni313 – 316Interaction with bacterial lipopeptide4

Sequence similaritiesi

Belongs to the Toll-like receptor family.Curated
Contains 19 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ15399.
KOiK05398.
OMAiIFHFAII.
OrthoDBiEOG091G0356.
PhylomeDBiQ15399.
TreeFamiTF351113.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027190. TLR1.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF261. PTHR24365:SF261. 2 hits.
PfamiPF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15399-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSIFHFAII FMLILQIRIQ LSEESEFLVD RSKNGLIHVP KDLSQKTTIL
60 70 80 90 100
NISQNYISEL WTSDILSLSK LRILIISHNR IQYLDISVFK FNQELEYLDL
110 120 130 140 150
SHNKLVKISC HPTVNLKHLD LSFNAFDALP ICKEFGNMSQ LKFLGLSTTH
160 170 180 190 200
LEKSSVLPIA HLNISKVLLV LGETYGEKED PEGLQDFNTE SLHIVFPTNK
210 220 230 240 250
EFHFILDVSV KTVANLELSN IKCVLEDNKC SYFLSILAKL QTNPKLSNLT
260 270 280 290 300
LNNIETTWNS FIRILQLVWH TTVWYFSISN VKLQGQLDFR DFDYSGTSLK
310 320 330 340 350
ALSIHQVVSD VFGFPQSYIY EIFSNMNIKN FTVSGTRMVH MLCPSKISPF
360 370 380 390 400
LHLDFSNNLL TDTVFENCGH LTELETLILQ MNQLKELSKI AEMTTQMKSL
410 420 430 440 450
QQLDISQNSV SYDEKKGDCS WTKSLLSLNM SSNILTDTIF RCLPPRIKVL
460 470 480 490 500
DLHSNKIKSI PKQVVKLEAL QELNVAFNSL TDLPGCGSFS SLSVLIIDHN
510 520 530 540 550
SVSHPSADFF QSCQKMRSIK AGDNPFQCTC ELGEFVKNID QVSSEVLEGW
560 570 580 590 600
PDSYKCDYPE SYRGTLLKDF HMSELSCNIT LLIVTIVATM LVLAVTVTSL
610 620 630 640 650
CSYLDLPWYL RMVCQWTQTR RRARNIPLEE LQRNLQFHAF ISYSGHDSFW
660 670 680 690 700
VKNELLPNLE KEGMQICLHE RNFVPGKSIV ENIITCIEKS YKSIFVLSPN
710 720 730 740 750
FVQSEWCHYE LYFAHHNLFH EGSNSLILIL LEPIPQYSIP SSYHKLKSLM
760 770 780
ARRTYLEWPK EKSKRGLFWA NLRAAINIKL TEQAKK
Length:786
Mass (Da):90,291
Last modified:May 1, 2007 - v3
Checksum:i1BFCCC5E42EA5242
GO

Sequence cautioni

The sequence BAA02801 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti182E → G in CAB43364 (PubMed:11230166).Curated1
Sequence conflicti228N → S in CAB43364 (PubMed:11230166).Curated1
Sequence conflicti276F → S in CAB43364 (PubMed:11230166).Curated1

Polymorphismi

Genetic variations in TLR1 may influence susceptibility to or protection against contracting leprosy and define the leprosy susceptibility locus 5 [MIMi:613223]. Ser-602 is a common allele in Caucasians. It is associated with impaired cell surface expression and receptor function resulting in protection against leprosy.

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06634044S → P.1 PublicationCorresponds to variant rs76600635dbSNPEnsembl.1
Natural variantiVAR_06634175I → T.1 PublicationCorresponds to variant rs137853170dbSNPEnsembl.1
Natural variantiVAR_03191680R → T.3 PublicationsCorresponds to variant rs5743611dbSNPEnsembl.1
Natural variantiVAR_018474118H → Y.1 PublicationCorresponds to variant rs5743612dbSNPEnsembl.1
Natural variantiVAR_031917248N → S May confer susceptibility to leprosy. 4 PublicationsCorresponds to variant rs4833095dbSNPEnsembl.1
Natural variantiVAR_031918305H → L.1 PublicationCorresponds to variant rs3923647dbSNPEnsembl.1
Natural variantiVAR_031919315P → L Severe impairment of activity. 1 PublicationCorresponds to variant rs5743613dbSNPEnsembl.1
Natural variantiVAR_066342352H → N.1 PublicationCorresponds to variant rs76796448dbSNPEnsembl.1
Natural variantiVAR_066343460I → V.1 PublicationCorresponds to variant rs137853171dbSNPEnsembl.1
Natural variantiVAR_066344542V → A.1 PublicationCorresponds to variant rs137853172dbSNPEnsembl.1
Natural variantiVAR_066345554Y → C Severe impairment of activity. 1 PublicationCorresponds to variant rs137853173dbSNPEnsembl.1
Natural variantiVAR_031920587V → G.1 PublicationCorresponds to variant rs5743617dbSNPEnsembl.1
Natural variantiVAR_031921602S → I Severe impairment of activity. 5 PublicationsCorresponds to variant rs5743618dbSNPEnsembl.1
Natural variantiVAR_052358631L → R.Corresponds to variant rs5743619dbSNPEnsembl.1
Natural variantiVAR_066346651V → A Severe impairment of activity. 1 PublicationCorresponds to variant rs137853174dbSNPEnsembl.1
Natural variantiVAR_066347674V → A.1 Publication1
Natural variantiVAR_066348720H → P Severe impairment of activity. 1 PublicationCorresponds to variant rs113706342dbSNPEnsembl.1
Natural variantiVAR_052359733P → L.1 PublicationCorresponds to variant rs5743621dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88540 mRNA. Translation: AAC34137.1.
AB445617 mRNA. Translation: BAG55014.1.
DQ012259 mRNA. Translation: AAY85638.1.
DQ012260 mRNA. Translation: AAY85639.1.
DQ012261 mRNA. Translation: AAY85640.1.
D13637 mRNA. Translation: BAA02801.2. Different initiation.
AL050262 mRNA. Translation: CAB43364.1.
BC109093 mRNA. Translation: AAI09094.1.
BC109094 mRNA. Translation: AAI09095.1.
CCDSiCCDS33973.1.
PIRiT08664.
RefSeqiNP_003254.2. NM_003263.3.
XP_005262719.1. XM_005262662.4.
XP_011512044.1. XM_011513742.2.
XP_011512045.1. XM_011513743.2.
XP_011512046.1. XM_011513744.2.
XP_011512047.1. XM_011513745.2.
XP_016864060.1. XM_017008571.1.
XP_016864061.1. XM_017008572.1.
UniGeneiHs.621817.
Hs.654532.

Genome annotation databases

EnsembliENST00000308979; ENSP00000354932; ENSG00000174125.
ENST00000502213; ENSP00000421259; ENSG00000174125.
GeneIDi7096.
KEGGihsa:7096.
UCSCiuc003gtl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U88540 mRNA. Translation: AAC34137.1.
AB445617 mRNA. Translation: BAG55014.1.
DQ012259 mRNA. Translation: AAY85638.1.
DQ012260 mRNA. Translation: AAY85639.1.
DQ012261 mRNA. Translation: AAY85640.1.
D13637 mRNA. Translation: BAA02801.2. Different initiation.
AL050262 mRNA. Translation: CAB43364.1.
BC109093 mRNA. Translation: AAI09094.1.
BC109094 mRNA. Translation: AAI09095.1.
CCDSiCCDS33973.1.
PIRiT08664.
RefSeqiNP_003254.2. NM_003263.3.
XP_005262719.1. XM_005262662.4.
XP_011512044.1. XM_011513742.2.
XP_011512045.1. XM_011513743.2.
XP_011512046.1. XM_011513744.2.
XP_011512047.1. XM_011513745.2.
XP_016864060.1. XM_017008571.1.
XP_016864061.1. XM_017008572.1.
UniGeneiHs.621817.
Hs.654532.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1FYVX-ray2.90A625-785[»]
2Z7XX-ray2.10B25-475[»]
ProteinModelPortaliQ15399.
SMRiQ15399.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112951. 10 interactors.
STRINGi9606.ENSP00000354932.

PTM databases

iPTMnetiQ15399.
PhosphoSitePlusiQ15399.

Polymorphism and mutation databases

BioMutaiTLR1.
DMDMi146291086.

Proteomic databases

EPDiQ15399.
PaxDbiQ15399.
PeptideAtlasiQ15399.
PRIDEiQ15399.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000308979; ENSP00000354932; ENSG00000174125.
ENST00000502213; ENSP00000421259; ENSG00000174125.
GeneIDi7096.
KEGGihsa:7096.
UCSCiuc003gtl.4. human.

Organism-specific databases

CTDi7096.
DisGeNETi7096.
GeneCardsiTLR1.
HGNCiHGNC:11847. TLR1.
MalaCardsiTLR1.
MIMi601194. gene.
613223. phenotype.
neXtProtiNX_Q15399.
OpenTargetsiENSG00000174125.
PharmGKBiPA36549.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4641. Eukaryota.
COG4886. LUCA.
GeneTreeiENSGT00760000119006.
HOGENOMiHOG000008676.
HOVERGENiHBG023180.
InParanoidiQ15399.
KOiK05398.
OMAiIFHFAII.
OrthoDBiEOG091G0356.
PhylomeDBiQ15399.
TreeFamiTF351113.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174125-MONOMER.
ReactomeiR-HSA-1236974. ER-Phagosome pathway.
R-HSA-1461957. Beta defensins.
R-HSA-166058. MyD88:Mal cascade initiated on plasma membrane.
R-HSA-168179. Toll Like Receptor TLR1:TLR2 Cascade.
R-HSA-5602498. MyD88 deficiency (TLR2/4).
R-HSA-5603041. IRAK4 deficiency (TLR2/4).
R-HSA-5686938. Regulation of TLR by endogenous ligand.
SIGNORiQ15399.

Miscellaneous databases

EvolutionaryTraceiQ15399.
GeneWikiiTLR_1.
GenomeRNAii7096.
PROiQ15399.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174125.
CleanExiHS_TLR1.
ExpressionAtlasiQ15399. baseline and differential.
GenevisibleiQ15399. HS.

Family and domain databases

Gene3Di3.40.50.10140. 1 hit.
3.80.10.10. 4 hits.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000157. TIR_dom.
IPR027190. TLR1.
IPR017241. Toll-like_receptor.
[Graphical view]
PANTHERiPTHR24365:SF261. PTHR24365:SF261. 2 hits.
PfamiPF13855. LRR_8. 2 hits.
PF01463. LRRCT. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
SMARTiSM00369. LRR_TYP. 4 hits.
SM00082. LRRCT. 1 hit.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 2 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS51450. LRR. 10 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTLR1_HUMAN
AccessioniPrimary (citable) accession number: Q15399
Secondary accession number(s): D1CS39
, D1CS41, O15452, Q32MK3, Q32MK4, Q9UG90
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 31, 2002
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 172 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.