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Q15399

- TLR1_HUMAN

UniProt

Q15399 - TLR1_HUMAN

Protein

Toll-like receptor 1

Gene

TLR1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 153 (01 Oct 2014)
      Sequence version 3 (01 May 2007)
      Previous versions | rss
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    Functioni

    Participates in the innate immune response to microbial agents. Specifically recognizes diacylated and triacylated lipopeptides. Cooperates with TLR2 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response By similarity.By similarity

    GO - Molecular functioni

    1. protein heterodimerization activity Source: MGI
    2. receptor activity Source: ProtInc
    3. transmembrane signaling receptor activity Source: UniProtKB

    GO - Biological processi

    1. cellular response to triacyl bacterial lipopeptide Source: MGI
    2. detection of triacyl bacterial lipopeptide Source: MGI
    3. immune response Source: ProtInc
    4. inflammatory response Source: UniProtKB-KW
    5. innate immune response Source: UniProtKB-KW
    6. macrophage activation Source: UniProtKB
    7. MyD88-dependent toll-like receptor signaling pathway Source: InterPro
    8. positive regulation of interleukin-6 biosynthetic process Source: UniProtKB
    9. positive regulation of tumor necrosis factor biosynthetic process Source: UniProtKB
    10. regulation of cytokine secretion Source: InterPro
    11. signal transduction Source: ProtInc
    12. toll-like receptor 1 signaling pathway Source: InterPro

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Immunity, Inflammatory response, Innate immunity

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Toll-like receptor 1
    Alternative name(s):
    Toll/interleukin-1 receptor-like protein
    Short name:
    TIL
    CD_antigen: CD281
    Gene namesi
    Name:TLR1
    Synonyms:KIAA0012
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:11847. TLR1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. membrane Source: UniProtKB
    3. phagocytic vesicle membrane Source: UniProtKB-SubCell
    4. plasma membrane Source: ProtInc
    5. Toll-like receptor 1-Toll-like receptor 2 protein complex Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasmic vesicle, Membrane

    Pathology & Biotechi

    Organism-specific databases

    MIMi613223. phenotype.
    PharmGKBiPA36549.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 24241 PublicationAdd
    BLAST
    Chaini25 – 786762Toll-like receptor 1PRO_0000034705Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi51 – 511N-linked (GlcNAc...)1 Publication
    Disulfide bondi110 ↔ 1321 Publication
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi163 – 1631N-linked (GlcNAc...)2 Publications
    Disulfide bondi223 ↔ 2301 Publication
    Glycosylationi330 – 3301N-linked (GlcNAc...)1 Publication
    Disulfide bondi343 ↔ 3681 Publication
    Disulfide bondi419 ↔ 4421 Publication
    Glycosylationi429 – 4291N-linked (GlcNAc...)1 Publication
    Glycosylationi578 – 5781N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ15399.
    PRIDEiQ15399.

    PTM databases

    PhosphoSiteiQ15399.

    Expressioni

    Tissue specificityi

    Ubiquitous. Highly expressed in spleen, ovary, peripheral blood leukocytes, thymus and small intestine.

    Gene expression databases

    ArrayExpressiQ15399.
    BgeeiQ15399.
    CleanExiHS_TLR1.
    GenevestigatoriQ15399.

    Interactioni

    Subunit structurei

    Binds MYD88 (via TIR domain). Interacts with CNPY3 By similarity. Interacts (via extracellular domain) with TLR2. Ligand binding induces the formation of a heterodimer with TLR2.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi112951. 2 interactions.
    STRINGi9606.ENSP00000354932.

    Structurei

    Secondary structure

    1
    786
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi28 – 303
    Beta strandi48 – 514
    Helixi62 – 654
    Beta strandi73 – 753
    Beta strandi83 – 853
    Helixi86 – 894
    Beta strandi97 – 993
    Beta strandi107 – 1093
    Beta strandi117 – 1204
    Helixi133 – 1375
    Beta strandi143 – 1508
    Helixi153 – 1597
    Beta strandi164 – 1718
    Helixi181 – 1844
    Beta strandi189 – 1957
    Beta strandi198 – 2003
    Beta strandi214 – 2185
    Beta strandi221 – 2233
    Turni227 – 2304
    Helixi231 – 2388
    Helixi239 – 2424
    Beta strandi248 – 25710
    Helixi258 – 26912
    Beta strandi274 – 28512
    Beta strandi301 – 3099
    Helixi317 – 3248
    Beta strandi329 – 3368
    Beta strandi352 – 3543
    Turni362 – 3676
    Beta strandi376 – 3783
    Helixi387 – 3948
    Beta strandi402 – 4043
    Helixi414 – 4163
    Beta strandi427 – 4293
    Helixi437 – 4415
    Beta strandi449 – 4513
    Helixi462 – 4665
    Beta strandi472 – 4743
    Beta strandi631 – 6333
    Beta strandi637 – 6426
    Helixi645 – 6473
    Helixi648 – 6536
    Helixi655 – 6606
    Turni661 – 6633
    Turni669 – 6724
    Helixi679 – 68911
    Beta strandi690 – 6989
    Helixi699 – 7046
    Helixi707 – 7126
    Beta strandi724 – 7329
    Helixi736 – 7383
    Helixi744 – 7518
    Helixi762 – 7643
    Helixi767 – 77711

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1FYVX-ray2.90A625-785[»]
    2Z7XX-ray2.10B25-475[»]
    ProteinModelPortaliQ15399.
    SMRiQ15399. Positions 25-578, 625-785.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15399.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 580556ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini602 – 786185CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei581 – 60121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati54 – 7724LRR 1Add
    BLAST
    Repeati78 – 10124LRR 2Add
    BLAST
    Repeati102 – 12524LRR 3Add
    BLAST
    Repeati126 – 15025LRR 4Add
    BLAST
    Repeati151 – 17525LRR 5Add
    BLAST
    Repeati176 – 19924LRR 6Add
    BLAST
    Repeati200 – 22324LRR 7Add
    BLAST
    Repeati224 – 25027LRR 8Add
    BLAST
    Repeati251 – 27828LRR 9Add
    BLAST
    Repeati279 – 30830LRR 10Add
    BLAST
    Repeati309 – 33729LRR 11Add
    BLAST
    Repeati338 – 36124LRR 12Add
    BLAST
    Repeati362 – 38827LRR 13Add
    BLAST
    Repeati389 – 41426LRR 14Add
    BLAST
    Repeati415 – 43723LRR 15Add
    BLAST
    Repeati438 – 45720LRR 16Add
    BLAST
    Repeati458 – 47821LRR 17Add
    BLAST
    Repeati479 – 50022LRR 18Add
    BLAST
    Repeati501 – 52424LRR 19Add
    BLAST
    Domaini525 – 57955LRRCTAdd
    BLAST
    Domaini635 – 779145TIRPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni313 – 3164Interaction with bacterial lipopeptide

    Sequence similaritiesi

    Belongs to the Toll-like receptor family.Curated
    Contains 19 LRR (leucine-rich) repeats.Curated
    Contains 1 LRRCT domain.Curated
    Contains 1 TIR domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG272762.
    HOGENOMiHOG000008676.
    HOVERGENiHBG023180.
    InParanoidiQ15399.
    KOiK05398.
    OMAiKEFGNMS.
    OrthoDBiEOG7GN2M5.
    PhylomeDBiQ15399.
    TreeFamiTF351113.

    Family and domain databases

    Gene3Di3.40.50.10140. 1 hit.
    InterProiIPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR000157. TIR_dom.
    IPR027190. TLR1.
    IPR017241. Toll-like_receptor.
    [Graphical view]
    PANTHERiPTHR24365:SF261. PTHR24365:SF261. 1 hit.
    PfamiPF13855. LRR_8. 2 hits.
    PF01582. TIR. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037595. Toll-like_receptor. 1 hit.
    SMARTiSM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view]
    SUPFAMiSSF52200. SSF52200. 1 hit.
    PROSITEiPS51450. LRR. 10 hits.
    PS50104. TIR. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q15399-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTSIFHFAII FMLILQIRIQ LSEESEFLVD RSKNGLIHVP KDLSQKTTIL    50
    NISQNYISEL WTSDILSLSK LRILIISHNR IQYLDISVFK FNQELEYLDL 100
    SHNKLVKISC HPTVNLKHLD LSFNAFDALP ICKEFGNMSQ LKFLGLSTTH 150
    LEKSSVLPIA HLNISKVLLV LGETYGEKED PEGLQDFNTE SLHIVFPTNK 200
    EFHFILDVSV KTVANLELSN IKCVLEDNKC SYFLSILAKL QTNPKLSNLT 250
    LNNIETTWNS FIRILQLVWH TTVWYFSISN VKLQGQLDFR DFDYSGTSLK 300
    ALSIHQVVSD VFGFPQSYIY EIFSNMNIKN FTVSGTRMVH MLCPSKISPF 350
    LHLDFSNNLL TDTVFENCGH LTELETLILQ MNQLKELSKI AEMTTQMKSL 400
    QQLDISQNSV SYDEKKGDCS WTKSLLSLNM SSNILTDTIF RCLPPRIKVL 450
    DLHSNKIKSI PKQVVKLEAL QELNVAFNSL TDLPGCGSFS SLSVLIIDHN 500
    SVSHPSADFF QSCQKMRSIK AGDNPFQCTC ELGEFVKNID QVSSEVLEGW 550
    PDSYKCDYPE SYRGTLLKDF HMSELSCNIT LLIVTIVATM LVLAVTVTSL 600
    CSYLDLPWYL RMVCQWTQTR RRARNIPLEE LQRNLQFHAF ISYSGHDSFW 650
    VKNELLPNLE KEGMQICLHE RNFVPGKSIV ENIITCIEKS YKSIFVLSPN 700
    FVQSEWCHYE LYFAHHNLFH EGSNSLILIL LEPIPQYSIP SSYHKLKSLM 750
    ARRTYLEWPK EKSKRGLFWA NLRAAINIKL TEQAKK 786
    Length:786
    Mass (Da):90,291
    Last modified:May 1, 2007 - v3
    Checksum:i1BFCCC5E42EA5242
    GO

    Sequence cautioni

    The sequence BAA02801.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti182 – 1821E → G in CAB43364. (PubMed:11230166)Curated
    Sequence conflicti228 – 2281N → S in CAB43364. (PubMed:11230166)Curated
    Sequence conflicti276 – 2761F → S in CAB43364. (PubMed:11230166)Curated

    Polymorphismi

    Genetic variations in TLR1 may influence susceptibility to or protection against contracting leprosy and define the leprosy susceptibility locus 5 [MIMi:613223]. Ser-602 is a common allele in Caucasians. It is associated with impaired cell surface expression and receptor function resulting in protection against leprosy.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti44 – 441S → P.1 Publication
    Corresponds to variant rs76600635 [ dbSNP | Ensembl ].
    VAR_066340
    Natural varianti75 – 751I → T.1 Publication
    Corresponds to variant rs137853170 [ dbSNP | Ensembl ].
    VAR_066341
    Natural varianti80 – 801R → T.3 Publications
    Corresponds to variant rs5743611 [ dbSNP | Ensembl ].
    VAR_031916
    Natural varianti118 – 1181H → Y.1 Publication
    Corresponds to variant rs5743612 [ dbSNP | Ensembl ].
    VAR_018474
    Natural varianti248 – 2481N → S May confer susceptibility to leprosy. 4 Publications
    Corresponds to variant rs4833095 [ dbSNP | Ensembl ].
    VAR_031917
    Natural varianti305 – 3051H → L.1 Publication
    Corresponds to variant rs3923647 [ dbSNP | Ensembl ].
    VAR_031918
    Natural varianti315 – 3151P → L Severe impairment of activity. 1 Publication
    Corresponds to variant rs5743613 [ dbSNP | Ensembl ].
    VAR_031919
    Natural varianti352 – 3521H → N.1 Publication
    Corresponds to variant rs76796448 [ dbSNP | Ensembl ].
    VAR_066342
    Natural varianti460 – 4601I → V.1 Publication
    Corresponds to variant rs137853171 [ dbSNP | Ensembl ].
    VAR_066343
    Natural varianti542 – 5421V → A.1 Publication
    Corresponds to variant rs137853172 [ dbSNP | Ensembl ].
    VAR_066344
    Natural varianti554 – 5541Y → C Severe impairment of activity. 1 Publication
    VAR_066345
    Natural varianti587 – 5871V → G.1 Publication
    Corresponds to variant rs5743617 [ dbSNP | Ensembl ].
    VAR_031920
    Natural varianti602 – 6021S → I Severe impairment of activity. 5 Publications
    Corresponds to variant rs5743618 [ dbSNP | Ensembl ].
    VAR_031921
    Natural varianti631 – 6311L → R.
    Corresponds to variant rs5743619 [ dbSNP | Ensembl ].
    VAR_052358
    Natural varianti651 – 6511V → A Severe impairment of activity. 1 Publication
    VAR_066346
    Natural varianti674 – 6741V → A.1 Publication
    VAR_066347
    Natural varianti720 – 7201H → P Severe impairment of activity. 1 Publication
    Corresponds to variant rs113706342 [ dbSNP | Ensembl ].
    VAR_066348
    Natural varianti733 – 7331P → L.1 Publication
    Corresponds to variant rs5743621 [ dbSNP | Ensembl ].
    VAR_052359

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88540 mRNA. Translation: AAC34137.1.
    AB445617 mRNA. Translation: BAG55014.1.
    DQ012259 mRNA. Translation: AAY85638.1.
    DQ012260 mRNA. Translation: AAY85639.1.
    DQ012261 mRNA. Translation: AAY85640.1.
    D13637 mRNA. Translation: BAA02801.2. Different initiation.
    AL050262 mRNA. Translation: CAB43364.1.
    BC109093 mRNA. Translation: AAI09094.1.
    BC109094 mRNA. Translation: AAI09095.1.
    CCDSiCCDS33973.1.
    PIRiT08664.
    RefSeqiNP_003254.2. NM_003263.3.
    XP_005262719.1. XM_005262662.2.
    XP_005262720.1. XM_005262663.2.
    XP_005262722.1. XM_005262665.2.
    XP_005262723.1. XM_005262666.2.
    XP_006714091.1. XM_006714028.1.
    UniGeneiHs.621817.
    Hs.654532.

    Genome annotation databases

    EnsembliENST00000308979; ENSP00000354932; ENSG00000174125.
    ENST00000502213; ENSP00000421259; ENSG00000174125.
    GeneIDi7096.
    KEGGihsa:7096.
    UCSCiuc003gtl.3. human.

    Polymorphism databases

    DMDMi146291086.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U88540 mRNA. Translation: AAC34137.1 .
    AB445617 mRNA. Translation: BAG55014.1 .
    DQ012259 mRNA. Translation: AAY85638.1 .
    DQ012260 mRNA. Translation: AAY85639.1 .
    DQ012261 mRNA. Translation: AAY85640.1 .
    D13637 mRNA. Translation: BAA02801.2 . Different initiation.
    AL050262 mRNA. Translation: CAB43364.1 .
    BC109093 mRNA. Translation: AAI09094.1 .
    BC109094 mRNA. Translation: AAI09095.1 .
    CCDSi CCDS33973.1.
    PIRi T08664.
    RefSeqi NP_003254.2. NM_003263.3.
    XP_005262719.1. XM_005262662.2.
    XP_005262720.1. XM_005262663.2.
    XP_005262722.1. XM_005262665.2.
    XP_005262723.1. XM_005262666.2.
    XP_006714091.1. XM_006714028.1.
    UniGenei Hs.621817.
    Hs.654532.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1FYV X-ray 2.90 A 625-785 [» ]
    2Z7X X-ray 2.10 B 25-475 [» ]
    ProteinModelPortali Q15399.
    SMRi Q15399. Positions 25-578, 625-785.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112951. 2 interactions.
    STRINGi 9606.ENSP00000354932.

    PTM databases

    PhosphoSitei Q15399.

    Polymorphism databases

    DMDMi 146291086.

    Proteomic databases

    PaxDbi Q15399.
    PRIDEi Q15399.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000308979 ; ENSP00000354932 ; ENSG00000174125 .
    ENST00000502213 ; ENSP00000421259 ; ENSG00000174125 .
    GeneIDi 7096.
    KEGGi hsa:7096.
    UCSCi uc003gtl.3. human.

    Organism-specific databases

    CTDi 7096.
    GeneCardsi GC04M038797.
    HGNCi HGNC:11847. TLR1.
    MIMi 601194. gene.
    613223. phenotype.
    neXtProti NX_Q15399.
    PharmGKBi PA36549.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG272762.
    HOGENOMi HOG000008676.
    HOVERGENi HBG023180.
    InParanoidi Q15399.
    KOi K05398.
    OMAi KEFGNMS.
    OrthoDBi EOG7GN2M5.
    PhylomeDBi Q15399.
    TreeFami TF351113.

    Miscellaneous databases

    EvolutionaryTracei Q15399.
    GeneWikii TLR_1.
    GenomeRNAii 7096.
    NextBioi 27759.
    PROi Q15399.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15399.
    Bgeei Q15399.
    CleanExi HS_TLR1.
    Genevestigatori Q15399.

    Family and domain databases

    Gene3Di 3.40.50.10140. 1 hit.
    InterProi IPR000483. Cys-rich_flank_reg_C.
    IPR001611. Leu-rich_rpt.
    IPR000157. TIR_dom.
    IPR027190. TLR1.
    IPR017241. Toll-like_receptor.
    [Graphical view ]
    PANTHERi PTHR24365:SF261. PTHR24365:SF261. 1 hit.
    Pfami PF13855. LRR_8. 2 hits.
    PF01582. TIR. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037595. Toll-like_receptor. 1 hit.
    SMARTi SM00082. LRRCT. 1 hit.
    SM00255. TIR. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52200. SSF52200. 1 hit.
    PROSITEi PS51450. LRR. 10 hits.
    PS50104. TIR. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A family of human receptors structurally related to Drosophila Toll."
      Rock F.L., Hardiman G., Timans J.C., Kastelein R.A., Bazan J.F.
      Proc. Natl. Acad. Sci. U.S.A. 95:588-593(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS SER-248 AND ILE-602.
      Tissue: Erythroleukemia.
    2. "Natural selection in the TLR-related genes in the course of primate evolution."
      Nakajima T., Ohtani H., Satta Y., Uno Y., Akari H., Ishida T., Kimura A.
      Immunogenetics 60:727-735(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "The heterogeneous allelic repertoire of human Toll-Like receptor (TLR) genes."
      Georgel P., Macquin C., Bahram S.
      PLoS ONE 4:E7803-E7803(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS THR-80 AND ILE-602.
    4. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT THR-80.
      Tissue: Bone marrow.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-248 AND ILE-602.
      Tissue: Brain.
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS SER-248 AND ILE-602.
    7. "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z., Henzel W.J.
      Protein Sci. 13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 25-39.
    8. "Cutting edge: A common polymorphism impairs cell surface trafficking and functional responses of TLR1 but protects against leprosy."
      Johnson C.M., Lyle E.A., Omueti K.O., Stepensky V.A., Yegin O., Alpsoy E., Hamann L., Schumann R.R., Tapping R.I.
      J. Immunol. 178:7520-7524(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: INVOLVEMENT IN PROTECTION AGAINST LEPROSY.
    9. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-163.
      Tissue: Liver.
    10. "Structural basis for signal transduction by the Toll/interleukin-1 receptor domains."
      Xu Y., Tao X., Shen B., Horng T., Medzhitov R., Manley J.L., Tong L.
      Nature 408:111-115(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 625-785.
    11. "Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide."
      Jin M.S., Kim S.E., Heo J.Y., Lee M.E., Kim H.M., Paik S.-G., Lee H., Lee J.-O.
      Cell 130:1071-1082(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 25-476 IN COMPLEX WITH TLR1 AND BACTERIAL LIPOPEPTIDE ANALOG, DISULFIDE BONDS, GLYCOSYLATION AT ASN-51; ASN-163; ASN-330 AND ASN-429.
    12. "Polymorphism N248S in the human Toll-like receptor 1 gene is related to leprosy and leprosy reactions."
      Schuring R.P., Hamann L., Faber W.R., Pahan D., Richardus J.H., Schumann R.R., Oskam L.
      J. Infect. Dis. 199:1816-1819(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION OF VARIANT SER-248 WITH SUSCEPTIBILITY TO LEPROSY.
    13. "Functional characterization of naturally occurring genetic variants in the human TLR1-2-6 gene family."
      Ben-Ali M., Corre B., Manry J., Barreiro L.B., Quach H., Boniotto M., Pellegrini S., Quintana-Murci L.
      Hum. Mutat. 32:643-652(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS PRO-44; THR-75; THR-80; TYR-118; SER-248; LEU-305; LEU-315; ASN-352; VAL-460; ALA-542; CYS-554; GLY-587; ILE-602; ALA-651; ALA-674; PRO-720 AND LEU-733, CHARACTERIZATION OF VARIANTS LEU-315; CYS-554; ILE-602; ALA-651 AND PRO-720.

    Entry informationi

    Entry nameiTLR1_HUMAN
    AccessioniPrimary (citable) accession number: Q15399
    Secondary accession number(s): D1CS39
    , D1CS41, O15452, Q32MK3, Q32MK4, Q9UG90
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 31, 2002
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 153 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3