Q15398 (DLGP5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Disks large-associated protein 5
Short name=DAP-5

Alternative name(s):
Discs large homolog 7
Disks large-associated protein DLG7
Hepatoma up-regulated protein
Short name=HURP

Gene names

Name:	DLGAP5
Synonyms:	DLG7, KIAA0008

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	846 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells. Ref.1 Ref.10 Ref.11
Subunit structure	Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1. Ref.10 Ref.11
Subcellular location	Nucleus. Cytoplasm. Cytoplasm › cytoskeleton › spindle. Note: Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells. Ref.1 Ref.10 Ref.13
Tissue specificity	Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta. Ref.1
Developmental stage	Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells. Ref.1
Post-translational modification	Ubiquitinated, leading to its degradation. Ref.11 Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.
Sequence similarities	Belongs to the SAPAP family.
Caution	It was localized to the spindle and the spindle pole (Ref.1) but was later found to be localized to the spindle and to be excluded from the spindle pole (Ref.13).
Sequence caution	The sequence BAA02797.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened. The sequence CAD62583.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Ontologies

Keywords
Biological process	Cell cycle
Cellular component	Cytoplasm Cytoskeleton Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Coiled coil
PTM	Phosphoprotein Ubl conjugation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell proliferation Non-traceable author statement Ref.1. Source: UniProtKB cell-cell signaling Inferred from electronic annotation. Source: InterPro mitotic chromosome movement towards spindle pole Non-traceable author statement Ref.1. Source: UniProtKB positive regulation of mitotic metaphase/anaphase transition Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from direct assay Ref.1. Source: UniProtKB spindle pole centrosome Inferred from direct assay Ref.1. Source: UniProtKB
Molecular_function	phosphoprotein phosphatase activity Inferred from direct assay Ref.11. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15398-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15398-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: Missing.

Note: No experimental confirmation available.

Isoform 3 (identifier: Q15398-3)

The sequence of this isoform differs from the canonical sequence as follows:
     807-846: PGLNCSNPFT...TFSPLQPGEF → VGSCYVARAG...AGTTARSKLQ

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 846	846	Disks large-associated protein 5		PRO_0000174299
Regions
	Coiled coil	90 – 120	31	Potential
Amino acid modifications
	Modified residue	67	1	Phosphoserine; by CDK1 Ref.11
	Modified residue	219	1	Phosphothreonine By similarity
	Modified residue	326	1	Phosphothreonine Ref.16
	Modified residue	329	1	Phosphothreonine; by CDK1 Ref.11 Ref.16
	Modified residue	338	1	Phosphothreonine Ref.16
	Modified residue	401	1	Phosphothreonine; by CDK1 Ref.11
	Modified residue	402	1	Phosphothreonine; by CDK1 Ref.11
	Modified residue	618	1	Phosphoserine; by CDK1 Ref.11 Ref.16
	Modified residue	627	1	Phosphoserine; by AURKA Ref.12
	Modified residue	639	1	Phosphothreonine; by CDK1 Ref.11
	Modified residue	642	1	Phosphoserine; by CDK1 Ref.11
	Modified residue	662	1	Phosphoserine Ref.16 Ref.17 Ref.19
	Modified residue	725	1	Phosphoserine; by AURKA Ref.12 Ref.16 Ref.17
	Modified residue	757	1	Phosphoserine; by AURKA Ref.12
	Modified residue	759	1	Phosphothreonine; by CDK1 Ref.11
	Modified residue	777	1	Phosphoserine Ref.14 Ref.17 Ref.19
	Modified residue	784	1	Phosphothreonine Ref.16
	Modified residue	806	1	Phosphoserine Ref.15 Ref.16
	Modified residue	812	1	Phosphoserine Ref.15 Ref.16
	Modified residue	830	1	Phosphoserine; by AURKA Ref.12 Ref.17
	Modified residue	839	1	Phosphoserine; by CDK1 Ref.11 Ref.17
Natural variations
	Alternative sequence	1 – 81	81	Missing in isoform 2.		VSP_015550
	Alternative sequence	807 – 846	40	PGLNC…QPGEF → VGSCYVARAGLEVLGSSDPT TSASRVAGTTARSKLQ in isoform 3.		VSP_045341
	Natural variant	69	1	G → E. Ref.1 Corresponds to variant rs2274271 [ dbSNP | Ensembl ].		VAR_023774
	Natural variant	324	1	Q → H. Corresponds to variant rs8010791 [ dbSNP | Ensembl ].		VAR_057718
	Natural variant	469	1	T → I. Corresponds to variant rs17128275 [ dbSNP | Ensembl ].		VAR_057719
	Natural variant	753	1	E → Q. Corresponds to variant rs35954941 [ dbSNP | Ensembl ].		VAR_062147
Experimental info
	Sequence conflict	253	1	E → K in BAA02797. Ref.2
	Sequence conflict	328	1	M → T in BAG61340. Ref.6

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified September 13, 2005. Version 2. Checksum: 588BAF238D6FFB72	FASTA	846	95,115
	10 20 30 40 50 60 MSSSHFASRH RKDISTEMIR TKIAHRKSLS QKENRHKEYE RNRHFGLKDV NIPTLEGRIL 70 80 90 100 110 120 VELDETSQGL VPEKTNVKPR AMKTILGDQR KQMLQKYKEE KQLQKLKEQR EKAKRGIFKV 130 140 150 160 170 180 GRYRPDMPCF LLSNQNAVKA EPKKAIPSSV RITRSKAKDQ MEQTKIDNES DVRAIRPGPR 190 200 210 220 230 240 QTSEKKVSDK EKKVVQPVMP TSLRMTRSAT QAAKQVPRTV SSTTARKPVT RAANENEPEG 250 260 270 280 290 300 KVPSKGRPAK NVETKPDKGI SCKVDSEENT LNSQTNATSG MNPDGVLSKM ENLPEINTAK 310 320 330 340 350 360 IKGKNSFAPK DFMFQPLDGL KTYQVTPMTP RSANAFLTPS YTWTPLKTEV DESQATKEIL 370 380 390 400 410 420 AQKCKTYSTK TIQQDSNKLP CPLGPLTVWH EEHVLNKNEA TTKNLNGLPI KEVPSLERNE 430 440 450 460 470 480 GRIAQPHHGV PYFRNILQSE TEKLTSHCFE WDRKLELDIP DDAKDLIRTA VGQTRLLMKE 490 500 510 520 530 540 RFKQFEGLVD DCEYKRGIKE TTCTDLDGFW DMVSFQIEDV IHKFNNLIKL EESGWQVNNN 550 560 570 580 590 600 MNHNMNKNVF RKKVVSGIAS KPKQDDAGRI AARNRLAAIK NAMRERIRQE ECAETAVSVI 610 620 630 640 650 660 PKEVDKIVFD AGFFRVESPV KLFSGLSVSS EGPSQRLGTP KSVNKAVSQS RNEMGIPQQT 670 680 690 700 710 720 TSPENAGPQN TKSEHVKKTL FLSIPESRSS IEDAQCPGLP DLIEENHVVN KTDLKVDCLS 730 740 750 760 770 780 SERMSLPLLA GGVADDINTN KKEGISDVVE GMELNSSITS QDVLMSSPEK NTASQNSILE 790 800 810 820 830 840 EGETKISQSE LFDNKSLTTE CHLLDSPGLN CSNPFTQLER RHQEHARHIS FGGNLITFSP LQPGEF
	Isoform 2 [UniParc]. Checksum: 00AFF91A02387EA1	FASTA	765	85,668
	10 20 30 40 50 60 MKTILGDQRK QMLQKYKEEK QLQKLKEQRE KAKRGIFKVG RYRPDMPCFL LSNQNAVKAE 70 80 90 100 110 120 PKKAIPSSVR ITRSKAKDQM EQTKIDNESD VRAIRPGPRQ TSEKKVSDKE KKVVQPVMPT 130 140 150 160 170 180 SLRMTRSATQ AAKQVPRTVS STTARKPVTR AANENEPEGK VPSKGRPAKN VETKPDKGIS 190 200 210 220 230 240 CKVDSEENTL NSQTNATSGM NPDGVLSKME NLPEINTAKI KGKNSFAPKD FMFQPLDGLK 250 260 270 280 290 300 TYQVTPMTPR SANAFLTPSY TWTPLKTEVD ESQATKEILA QKCKTYSTKT IQQDSNKLPC 310 320 330 340 350 360 PLGPLTVWHE EHVLNKNEAT TKNLNGLPIK EVPSLERNEG RIAQPHHGVP YFRNILQSET 370 380 390 400 410 420 EKLTSHCFEW DRKLELDIPD DAKDLIRTAV GQTRLLMKER FKQFEGLVDD CEYKRGIKET 430 440 450 460 470 480 TCTDLDGFWD MVSFQIEDVI HKFNNLIKLE ESGWQVNNNM NHNMNKNVFR KKVVSGIASK 490 500 510 520 530 540 PKQDDAGRIA ARNRLAAIKN AMRERIRQEE CAETAVSVIP KEVDKIVFDA GFFRVESPVK 550 560 570 580 590 600 LFSGLSVSSE GPSQRLGTPK SVNKAVSQSR NEMGIPQQTT SPENAGPQNT KSEHVKKTLF 610 620 630 640 650 660 LSIPESRSSI EDAQCPGLPD LIEENHVVNK TDLKVDCLSS ERMSLPLLAG GVADDINTNK 670 680 690 700 710 720 KEGISDVVEG MELNSSITSQ DVLMSSPEKN TASQNSILEE GETKISQSEL FDNKSLTTEC 730 740 750 760 HLLDSPGLNC SNPFTQLERR HQEHARHISF GGNLITFSPL QPGEF
	Isoform 3 [UniParc]. Checksum: FDEF1E4B900F758C	FASTA	842	94,178
	10 20 30 40 50 60 MSSSHFASRH RKDISTEMIR TKIAHRKSLS QKENRHKEYE RNRHFGLKDV NIPTLEGRIL 70 80 90 100 110 120 VELDETSQGL VPEKTNVKPR AMKTILGDQR KQMLQKYKEE KQLQKLKEQR EKAKRGIFKV 130 140 150 160 170 180 GRYRPDMPCF LLSNQNAVKA EPKKAIPSSV RITRSKAKDQ MEQTKIDNES DVRAIRPGPR 190 200 210 220 230 240 QTSEKKVSDK EKKVVQPVMP TSLRMTRSAT QAAKQVPRTV SSTTARKPVT RAANENEPEG 250 260 270 280 290 300 KVPSKGRPAK NVETKPDKGI SCKVDSEENT LNSQTNATSG MNPDGVLSKM ENLPEINTAK 310 320 330 340 350 360 IKGKNSFAPK DFMFQPLDGL KTYQVTPMTP RSANAFLTPS YTWTPLKTEV DESQATKEIL 370 380 390 400 410 420 AQKCKTYSTK TIQQDSNKLP CPLGPLTVWH EEHVLNKNEA TTKNLNGLPI KEVPSLERNE 430 440 450 460 470 480 GRIAQPHHGV PYFRNILQSE TEKLTSHCFE WDRKLELDIP DDAKDLIRTA VGQTRLLMKE 490 500 510 520 530 540 RFKQFEGLVD DCEYKRGIKE TTCTDLDGFW DMVSFQIEDV IHKFNNLIKL EESGWQVNNN 550 560 570 580 590 600 MNHNMNKNVF RKKVVSGIAS KPKQDDAGRI AARNRLAAIK NAMRERIRQE ECAETAVSVI 610 620 630 640 650 660 PKEVDKIVFD AGFFRVESPV KLFSGLSVSS EGPSQRLGTP KSVNKAVSQS RNEMGIPQQT 670 680 690 700 710 720 TSPENAGPQN TKSEHVKKTL FLSIPESRSS IEDAQCPGLP DLIEENHVVN KTDLKVDCLS 730 740 750 760 770 780 SERMSLPLLA GGVADDINTN KKEGISDVVE GMELNSSITS QDVLMSSPEK NTASQNSILE 790 800 810 820 830 840 EGETKISQSE LFDNKSLTTE CHLLDSVGSC YVARAGLEVL GSSDPTTSAS RVAGTTARSK LQ

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma." Tsou A.-P., Yang C.-W., Huang C.-Y.F., Yu R.C.-T., Lee Y.-C.G., Chang C.-W., Chen B.-R., Chung Y.-F., Fann M.-J., Chi C.-W., Chiu J.-H., Chou C.-K. Oncogene 22:298-307(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-69, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
[2]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Bone marrow.
[3]	Ohara O., Nagase T., Kikuno R., Nomura N. Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION TO 253.
[4]	"Full-length cDNA libraries and normalization." Li W.B., Gruber C., Jessee J., Polayes D. Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: T-cell.
[5]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
[6]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[7]	"The DNA sequence and analysis of human chromosome 14." Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H. , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J. Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Eye and Lung.
[10]	"Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells." Laprise P., Viel A., Rivard N. J. Biol. Chem. 279:10157-10166(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CDH1, SUBCELLULAR LOCATION, PHOSPHORYLATION.
[11]	"Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region." Hsu J.-M., Lee Y.-C.G., Yu C.-T.R., Huang C.-Y.F. J. Biol. Chem. 279:32592-32602(2004) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, INTERACTION WITH CDK1; FBXO7 AND SCF COMPLEX, UBIQUITINATION, PHOSPHORYLATION AT SER-67; THR-329; THR-401; THR-402; SER-618; THR-639; SER-642; THR-759 AND SER-839.
[12]	"Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A." Yu C.T., Hsu J.M., Lee Y.C., Tsou A.P., Chou C.K., Huang C.Y. Mol. Cell. Biol. 25:5789-5800(2005) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT SER-627; SER-725; SER-757 AND SER-830.
[13]	"Proteome analysis of the human mitotic spindle." Sauer G., Koerner R., Hanisch A., Ries A., Nigg E.A., Sillje H.H.W. Mol. Cell. Proteomics 4:35-43(2005) [PubMed] [Europe PMC] [Abstract] Cited for: SUBCELLULAR LOCATION, MASS SPECTROMETRY.
[14]	"A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-777, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[15]	"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis." Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-806 AND SER-812, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[16]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-326; THR-329; THR-338; SER-618; SER-662; SER-725; THR-784; SER-806 AND SER-812, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[17]	"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M. Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-662; SER-725; SER-777; SER-830 AND SER-839, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[18]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[19]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-662 AND SER-777, MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB076695 mRNA. Translation: BAB97376.1. D13633 mRNA. Translation: BAA02797.3. Different initiation. BX248255 mRNA. Translation: CAD62583.1. Different initiation. BT007344 mRNA. Translation: AAP36008.1. AK299338 mRNA. Translation: BAG61340.1. AL139316 Genomic DNA. No translation available. CH471061 Genomic DNA. Translation: EAW80664.1. BC010658 mRNA. Translation: AAH10658.2. BC016276 mRNA. Translation: AAH16276.2.
IPI	IPI00184997. IPI00647106. IPI00647892.
RefSeq	NP_001139487.1. NM_001146015.1. NP_055565.3. NM_014750.4.
UniGene	Hs.77695.
3D structure databases
ProteinModelPortal	Q15398.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15398. 2 interactions.
STRING	9606.ENSP00000247191.
PTM databases
PhosphoSite	Q15398.
Polymorphism databases
DMDM	82592583.
Proteomic databases
PaxDb	Q15398.
PRIDE	Q15398.
Protocols and materials databases
DNASU	9787.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000247191; ENSP00000247191; ENSG00000126787. ENST00000395425; ENSP00000378815; ENSG00000126787.
GeneID	9787.
KEGG	hsa:9787.
UCSC	uc001xbs.3. human.
Organism-specific databases
CTD	9787.
GeneCards	GC14M055614.
H-InvDB	HIX0011684.
HGNC	HGNC:16864. DLGAP5.
HPA	HPA005546.
neXtProt	NX_Q15398.
PharmGKB	PA162383761.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG270787.
HOGENOM	HOG000054220.
HOVERGEN	HBG062172.
KO	K16804.
OMA	FAPKDFM.
OrthoDB	EOG4RXXZQ.
Enzyme and pathway databases
Pathway_Interaction_DB	aurora_a_pathway. Aurora A signaling.
Gene expression databases
ArrayExpress	Q15398.
Bgee	Q15398.
CleanEx	HS_DLGAP5.
Genevestigator	Q15398.
GermOnline	ENSG00000126787. Homo sapiens.
Family and domain databases
InterPro	IPR005026. GKAP. [Graphical view]
Pfam	PF03359. GKAP. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	9787.
NextBio	36854.

Entry information

Entry name

DLGP5_HUMAN

Accession

Primary (citable) accession number: Q15398
Secondary accession number(s): A8MTM6 , B4DRM8, Q86T11, Q8NG58

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	September 13, 2005
Last modified:	April 3, 2013
This is version 112 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.