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Q15398

- DLGP5_HUMAN

UniProt

Q15398 - DLGP5_HUMAN

Protein

Disks large-associated protein 5

Gene

DLGAP5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    Potential cell cycle regulator that may play a role in carcinogenesis of cancer cells. Mitotic phosphoprotein regulated by the ubiquitin-proteasome pathway. Key regulator of adherens junction integrity and differentiation that may be involved in CDH1-mediated adhesion and signaling in epithelial cells.3 Publications

    GO - Molecular functioni

    1. phosphoprotein phosphatase activity Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell-cell signaling Source: InterPro
    2. cell proliferation Source: UniProtKB
    3. dephosphorylation Source: GOC
    4. mitotic chromosome movement towards spindle pole Source: UniProtKB
    5. mitotic M phase Source: UniProtKB
    6. positive regulation of mitotic metaphase/anaphase transition Source: UniProtKB

    Keywords - Biological processi

    Cell cycle

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Disks large-associated protein 5
    Short name:
    DAP-5
    Alternative name(s):
    Discs large homolog 7
    Disks large-associated protein DLG7
    Hepatoma up-regulated protein
    Short name:
    HURP
    Gene namesi
    Name:DLGAP5
    Synonyms:DLG7, KIAA0008
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:16864. DLGAP5.

    Subcellular locationi

    Nucleus. Cytoplasm. Cytoplasmcytoskeletonspindle
    Note: Localizes to the spindle in mitotic cells. Colocalizes with CDH1 at sites of cell-cell contact in intestinal epithelial cells.

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. microtubule organizing center Source: HPA
    3. nucleus Source: UniProtKB
    4. spindle pole centrosome Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA162383761.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 846846Disks large-associated protein 5PRO_0000174299Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei67 – 671Phosphoserine; by CDK12 Publications
    Modified residuei326 – 3261Phosphothreonine2 Publications
    Modified residuei329 – 3291Phosphothreonine; by CDK13 Publications
    Modified residuei338 – 3381Phosphothreonine2 Publications
    Modified residuei401 – 4011Phosphothreonine; by CDK12 Publications
    Modified residuei402 – 4021Phosphothreonine; by CDK12 Publications
    Modified residuei618 – 6181Phosphoserine; by CDK13 Publications
    Modified residuei627 – 6271Phosphoserine; by AURKA2 Publications
    Modified residuei639 – 6391Phosphothreonine; by CDK12 Publications
    Modified residuei642 – 6421Phosphoserine; by CDK12 Publications
    Modified residuei662 – 6621Phosphoserine4 Publications
    Modified residuei725 – 7251Phosphoserine; by AURKA4 Publications
    Modified residuei757 – 7571Phosphoserine; by AURKA2 Publications
    Modified residuei759 – 7591Phosphothreonine; by CDK12 Publications
    Modified residuei777 – 7771Phosphoserine4 Publications
    Modified residuei784 – 7841Phosphothreonine2 Publications
    Modified residuei806 – 8061Phosphoserine3 Publications
    Modified residuei812 – 8121Phosphoserine3 Publications
    Modified residuei830 – 8301Phosphoserine; by AURKA3 Publications
    Modified residuei839 – 8391Phosphoserine; by CDK13 Publications

    Post-translational modificationi

    Ubiquitinated, leading to its degradation.1 Publication
    Decreased phosphorylation levels are associated with the differentiation of intestinal epithelial cells.8 Publications

    Keywords - PTMi

    Phosphoprotein, Ubl conjugation

    Proteomic databases

    MaxQBiQ15398.
    PaxDbiQ15398.
    PRIDEiQ15398.

    PTM databases

    PhosphoSiteiQ15398.

    Expressioni

    Tissue specificityi

    Abundantly expressed in fetal liver. Expressed at lower levels in bone marrow, testis, colon, and placenta.1 Publication

    Developmental stagei

    Elevated levels of expression detected in the G2/M phase of synchronized cultures of HeLa cells.1 Publication

    Gene expression databases

    ArrayExpressiQ15398.
    BgeeiQ15398.
    CleanExiHS_DLGAP5.
    GenevestigatoriQ15398.

    Organism-specific databases

    HPAiHPA005546.

    Interactioni

    Subunit structurei

    Interacts with CDK1. Interacts with the C-terminal proline-rich region of FBXO7. Recruited by FBXO7 to a SCF (SKP1-CUL1-F-box) protein complex in a CDK1/Cyclin B-phosphorylation dependent manner. Interacts with CDH1.2 Publications

    Protein-protein interaction databases

    BioGridi115131. 8 interactions.
    IntActiQ15398. 2 interactions.
    MINTiMINT-1465344.
    STRINGi9606.ENSP00000247191.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15398.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili90 – 12031Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the SAPAP family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG270787.
    HOGENOMiHOG000054220.
    HOVERGENiHBG062172.
    KOiK16804.
    OMAiFAPKDFM.
    OrthoDBiEOG75QR37.
    PhylomeDBiQ15398.
    TreeFamiTF321382.

    Family and domain databases

    InterProiIPR005026. GKAP.
    [Graphical view]
    PfamiPF03359. GKAP. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15398-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSSSHFASRH RKDISTEMIR TKIAHRKSLS QKENRHKEYE RNRHFGLKDV    50
    NIPTLEGRIL VELDETSQGL VPEKTNVKPR AMKTILGDQR KQMLQKYKEE 100
    KQLQKLKEQR EKAKRGIFKV GRYRPDMPCF LLSNQNAVKA EPKKAIPSSV 150
    RITRSKAKDQ MEQTKIDNES DVRAIRPGPR QTSEKKVSDK EKKVVQPVMP 200
    TSLRMTRSAT QAAKQVPRTV SSTTARKPVT RAANENEPEG KVPSKGRPAK 250
    NVETKPDKGI SCKVDSEENT LNSQTNATSG MNPDGVLSKM ENLPEINTAK 300
    IKGKNSFAPK DFMFQPLDGL KTYQVTPMTP RSANAFLTPS YTWTPLKTEV 350
    DESQATKEIL AQKCKTYSTK TIQQDSNKLP CPLGPLTVWH EEHVLNKNEA 400
    TTKNLNGLPI KEVPSLERNE GRIAQPHHGV PYFRNILQSE TEKLTSHCFE 450
    WDRKLELDIP DDAKDLIRTA VGQTRLLMKE RFKQFEGLVD DCEYKRGIKE 500
    TTCTDLDGFW DMVSFQIEDV IHKFNNLIKL EESGWQVNNN MNHNMNKNVF 550
    RKKVVSGIAS KPKQDDAGRI AARNRLAAIK NAMRERIRQE ECAETAVSVI 600
    PKEVDKIVFD AGFFRVESPV KLFSGLSVSS EGPSQRLGTP KSVNKAVSQS 650
    RNEMGIPQQT TSPENAGPQN TKSEHVKKTL FLSIPESRSS IEDAQCPGLP 700
    DLIEENHVVN KTDLKVDCLS SERMSLPLLA GGVADDINTN KKEGISDVVE 750
    GMELNSSITS QDVLMSSPEK NTASQNSILE EGETKISQSE LFDNKSLTTE 800
    CHLLDSPGLN CSNPFTQLER RHQEHARHIS FGGNLITFSP LQPGEF 846
    Length:846
    Mass (Da):95,115
    Last modified:September 13, 2005 - v2
    Checksum:i588BAF238D6FFB72
    GO
    Isoform 2 (identifier: Q15398-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-81: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:765
    Mass (Da):85,668
    Checksum:i00AFF91A02387EA1
    GO
    Isoform 3 (identifier: Q15398-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         807-846: PGLNCSNPFT...TFSPLQPGEF → VGSCYVARAG...AGTTARSKLQ

    Note: No experimental confirmation available.

    Show »
    Length:842
    Mass (Da):94,178
    Checksum:iFDEF1E4B900F758C
    GO

    Sequence cautioni

    The sequence BAA02797.3 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.
    The sequence CAD62583.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti253 – 2531E → K in BAA02797. (PubMed:7584026)Curated
    Sequence conflicti328 – 3281M → T in BAG61340. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti69 – 691G → E.1 Publication
    Corresponds to variant rs2274271 [ dbSNP | Ensembl ].
    VAR_023774
    Natural varianti324 – 3241Q → H.
    Corresponds to variant rs8010791 [ dbSNP | Ensembl ].
    VAR_057718
    Natural varianti469 – 4691T → I.
    Corresponds to variant rs17128275 [ dbSNP | Ensembl ].
    VAR_057719
    Natural varianti753 – 7531E → Q.
    Corresponds to variant rs35954941 [ dbSNP | Ensembl ].
    VAR_062147

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 8181Missing in isoform 2. 1 PublicationVSP_015550Add
    BLAST
    Alternative sequencei807 – 84640PGLNC…QPGEF → VGSCYVARAGLEVLGSSDPT TSASRVAGTTARSKLQ in isoform 3. 1 PublicationVSP_045341Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076695 mRNA. Translation: BAB97376.1.
    D13633 mRNA. Translation: BAA02797.3. Different initiation.
    BX248255 mRNA. Translation: CAD62583.1. Different initiation.
    BT007344 mRNA. Translation: AAP36008.1.
    AK299338 mRNA. Translation: BAG61340.1.
    AL139316 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80664.1.
    BC010658 mRNA. Translation: AAH10658.2.
    BC016276 mRNA. Translation: AAH16276.2.
    CCDSiCCDS53897.1. [Q15398-3]
    CCDS9723.1. [Q15398-2]
    RefSeqiNP_001139487.1. NM_001146015.1. [Q15398-3]
    NP_055565.3. NM_014750.4. [Q15398-2]
    UniGeneiHs.77695.

    Genome annotation databases

    EnsembliENST00000247191; ENSP00000247191; ENSG00000126787. [Q15398-2]
    ENST00000395425; ENSP00000378815; ENSG00000126787. [Q15398-3]
    GeneIDi9787.
    KEGGihsa:9787.
    UCSCiuc001xbs.3. human. [Q15398-2]
    uc001xbt.3. human.

    Polymorphism databases

    DMDMi82592583.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076695 mRNA. Translation: BAB97376.1 .
    D13633 mRNA. Translation: BAA02797.3 . Different initiation.
    BX248255 mRNA. Translation: CAD62583.1 . Different initiation.
    BT007344 mRNA. Translation: AAP36008.1 .
    AK299338 mRNA. Translation: BAG61340.1 .
    AL139316 Genomic DNA. No translation available.
    CH471061 Genomic DNA. Translation: EAW80664.1 .
    BC010658 mRNA. Translation: AAH10658.2 .
    BC016276 mRNA. Translation: AAH16276.2 .
    CCDSi CCDS53897.1. [Q15398-3 ]
    CCDS9723.1. [Q15398-2 ]
    RefSeqi NP_001139487.1. NM_001146015.1. [Q15398-3 ]
    NP_055565.3. NM_014750.4. [Q15398-2 ]
    UniGenei Hs.77695.

    3D structure databases

    ProteinModelPortali Q15398.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115131. 8 interactions.
    IntActi Q15398. 2 interactions.
    MINTi MINT-1465344.
    STRINGi 9606.ENSP00000247191.

    PTM databases

    PhosphoSitei Q15398.

    Polymorphism databases

    DMDMi 82592583.

    Proteomic databases

    MaxQBi Q15398.
    PaxDbi Q15398.
    PRIDEi Q15398.

    Protocols and materials databases

    DNASUi 9787.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000247191 ; ENSP00000247191 ; ENSG00000126787 . [Q15398-2 ]
    ENST00000395425 ; ENSP00000378815 ; ENSG00000126787 . [Q15398-3 ]
    GeneIDi 9787.
    KEGGi hsa:9787.
    UCSCi uc001xbs.3. human. [Q15398-2 ]
    uc001xbt.3. human.

    Organism-specific databases

    CTDi 9787.
    GeneCardsi GC14M055614.
    H-InvDB HIX0011684.
    HGNCi HGNC:16864. DLGAP5.
    HPAi HPA005546.
    neXtProti NX_Q15398.
    PharmGKBi PA162383761.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG270787.
    HOGENOMi HOG000054220.
    HOVERGENi HBG062172.
    KOi K16804.
    OMAi FAPKDFM.
    OrthoDBi EOG75QR37.
    PhylomeDBi Q15398.
    TreeFami TF321382.

    Miscellaneous databases

    GeneWikii DLGAP5.
    GenomeRNAii 9787.
    NextBioi 36854.
    PROi Q15398.

    Gene expression databases

    ArrayExpressi Q15398.
    Bgeei Q15398.
    CleanExi HS_DLGAP5.
    Genevestigatori Q15398.

    Family and domain databases

    InterProi IPR005026. GKAP.
    [Graphical view ]
    Pfami PF03359. GKAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel cell cycle regulated gene, HURP, overexpressed in human hepatocellular carcinoma."
      Tsou A.-P., Yang C.-W., Huang C.-Y.F., Yu R.C.-T., Lee Y.-C.G., Chang C.-W., Chen B.-R., Chung Y.-F., Fann M.-J., Chi C.-W., Chiu J.-H., Chou C.-K.
      Oncogene 22:298-307(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLU-69, FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    2. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    3. Ohara O., Nagase T., Kikuno R., Nomura N.
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION TO 253.
    4. "Full-length cDNA libraries and normalization."
      Li W.B., Gruber C., Jessee J., Polayes D.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: T-cell.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    6. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
    7. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Eye and Lung.
    10. "Human homolog of disc-large is required for adherens junction assembly and differentiation of human intestinal epithelial cells."
      Laprise P., Viel A., Rivard N.
      J. Biol. Chem. 279:10157-10166(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CDH1, SUBCELLULAR LOCATION, PHOSPHORYLATION.
    11. "Fbx7 functions in the SCF complex regulating Cdk1-cyclin B-phosphorylated hepatoma up-regulated protein (HURP) proteolysis by a proline-rich region."
      Hsu J.-M., Lee Y.-C.G., Yu C.-T.R., Huang C.-Y.F.
      J. Biol. Chem. 279:32592-32602(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH CDK1; FBXO7 AND SCF COMPLEX, UBIQUITINATION, PHOSPHORYLATION AT SER-67; THR-329; THR-401; THR-402; SER-618; THR-639; SER-642; THR-759 AND SER-839.
    12. "Phosphorylation and stabilization of HURP by Aurora-A: implication of HURP as a transforming target of Aurora-A."
      Yu C.T., Hsu J.M., Lee Y.C., Tsou A.P., Chou C.K., Huang C.Y.
      Mol. Cell. Biol. 25:5789-5800(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-627; SER-725; SER-757 AND SER-830.
    13. Cited for: SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    14. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-777, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D., Yates J.R. III
      J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-806 AND SER-812, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-326; THR-329; THR-338; SER-618; SER-662; SER-725; THR-784; SER-806 AND SER-812, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    17. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-662; SER-725; SER-777; SER-830 AND SER-839, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    18. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-662 AND SER-777, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiDLGP5_HUMAN
    AccessioniPrimary (citable) accession number: Q15398
    Secondary accession number(s): A8MTM6
    , B4DRM8, Q86T11, Q8NG58
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3