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Q15397

- K0020_HUMAN

UniProt

Q15397 - K0020_HUMAN

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Protein

Pumilio domain-containing protein KIAA0020

Gene

KIAA0020

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. poly(A) RNA binding Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pumilio domain-containing protein KIAA0020
Alternative name(s):
HBV X-transactivated gene 5 protein
HBV XAg-transactivated protein 5
Minor histocompatibility antigen HA-8
Short name:
HLA-HA8
Gene namesi
Name:KIAA0020
Synonyms:XTP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:29676. KIAA0020.

Subcellular locationi

Nucleusnucleolus 2 Publications

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB
  2. nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134895115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Pumilio domain-containing protein KIAA0020PRO_0000075929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ15397.
PaxDbiQ15397.
PRIDEiQ15397.

2D gel databases

SWISS-2DPAGEQ15397.

PTM databases

PhosphoSiteiQ15397.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ15397.
CleanExiHS_KIAA0020.
ExpressionAtlasiQ15397. baseline and differential.
GenevestigatoriQ15397.

Organism-specific databases

HPAiHPA002353.

Interactioni

Protein-protein interaction databases

BioGridi115259. 19 interactions.
IntActiQ15397. 3 interactions.
MINTiMINT-1404790.

Structurei

3D structure databases

ProteinModelPortaliQ15397.
SMRiQ15397. Positions 166-464.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 510368PUM-HDPROSITE-ProRule annotationAdd
BLAST
Repeati165 – 20036Pumilio 1Add
BLAST
Repeati201 – 23636Pumilio 2Add
BLAST
Repeati237 – 27337Pumilio 3Add
BLAST
Repeati350 – 38536Pumilio 4Add
BLAST
Repeati386 – 42237Pumilio 5Add
BLAST
Repeati424 – 46037Pumilio 6Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni289 – 2979HA-8

Domaini

The HA-8 region can be cleaved and exposed at the cell surface where it plays a role as a minor histocompatibility HLA-A*0201-restricted antigen.

Sequence similaritiesi

Contains 1 PUM-HD domain.PROSITE-ProRule annotation
Contains 6 pumilio repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG273657.
GeneTreeiENSGT00390000015757.
HOVERGENiHBG052166.
InParanoidiQ15397.
KOiK14844.
OMAiCLWHGTA.
OrthoDBiEOG783MV2.
PhylomeDBiQ15397.
TreeFamiTF312954.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR012959. CPL.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
PfamiPF08144. CPL. 1 hit.
[Graphical view]
SMARTiSM00025. Pumilio. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50302. PUM. 5 hits.
PS50303. PUM_HD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15397-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVKGKKQFT GKSTKTAQEK NRFHKNSDSG SSKTFPTRKV AKEGGPKVTS
60 70 80 90 100
RNFEKSITKL GKKGVKQFKN KQQGDKSPKN KFQPANKFNK KRKFQPDGRS
110 120 130 140 150
DESAAKKPKW DDFKKKKKEL KQSRQLSDKT NYDIVVRAKQ MWEILRRKDC
160 170 180 190 200
DKEKRVKLMS DLQKLIQGKI KTIAFAHDST RVIQCYIQYG NEEQRKQAFE
210 220 230 240 250
ELRDDLVELS KAKYSRNIVK KFLMYGSKPQ IAEIIRSFKG HVRKMLRHAE
260 270 280 290 300
ASAIVEYAYN DKAILEQRNM LTEELYGNTF QLYKSADHRT LDKVLEVQPE
310 320 330 340 350
KLELIMDEMK QILTPMAQKE AVIKHSLVHK VFLDFFTYAP PKLRSEMIEA
360 370 380 390 400
IREAVVYLAH THDGARVAMH CLWHGTPKDR KVIVKTMKTY VEKVANGQYS
410 420 430 440 450
HLVLLAAFDC IDDTKLVKQI IISEIISSLP SIVNDKYGRK VLLYLLSPRD
460 470 480 490 500
PAHTVREIIE VLQKGDGNAH SKKDTEVRRR ELLESISPAL LSYLQEHAQE
510 520 530 540 550
VVLDKSACVL VSDILGSATG DVQPTMNAIA SLAATGLHPG GKDGELHIAE
560 570 580 590 600
HPAGHLVLKW LIEQDKKMKE NGREGCFAKT LVEHVGMKNL KSWASVNRGA
610 620 630 640
IILSSLLQSC DLEVANKVKA ALKSLIPTLE KTKSTSKGIE ILLEKLST
Length:648
Mass (Da):73,584
Last modified:November 8, 2005 - v3
Checksum:i449BFBF22F1BBA86
GO

Sequence cautioni

The sequence BAA02808.1 differs from that shown. Reason: Erroneous initiation.
The sequence CAI12924.2 differs from that shown. Reason: Erroneous gene model prediction.
The sequence CAI15123.2 differs from that shown. Reason: Erroneous gene model prediction.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti625 – 6251L → S in CAG33238. 1 PublicationCurated

Polymorphismi

The following alleles of HA-8 are known: HA-8R, HA-8P, HA-8PL, of which only HA-8R leads to specific cytotoxic T lymphocyte (CTL) recognition. The lack of CTL recognition of cells expressing HA-8P may be due to impaired transport associated with antigen processing. The sequence shown is that of HA-8R.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131S → N.1 Publication
Corresponds to variant rs10968457 [ dbSNP | Ensembl ].
VAR_051613
Natural varianti264 – 2641I → V.
Corresponds to variant rs35869387 [ dbSNP | Ensembl ].
VAR_051614
Natural varianti289 – 2891R → P in allele HA-8P and allele HA-8PL.
Corresponds to variant rs2173904 [ dbSNP | Ensembl ].
VAR_023772
Natural varianti297 – 2971V → L in allele HA-8PL.
Corresponds to variant rs2270891 [ dbSNP | Ensembl ].
VAR_023773
Natural varianti414 – 4141T → S.
Corresponds to variant rs3736390 [ dbSNP | Ensembl ].
VAR_051615
Natural varianti480 – 4801R → Q.
Corresponds to variant rs2270889 [ dbSNP | Ensembl ].
VAR_051616

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK292169 mRNA. Translation: BAF84858.1.
AL354723, AL589675 Genomic DNA. Translation: CAI15123.2. Sequence problems.
AL589675, AL354723 Genomic DNA. Translation: CAI12924.2. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58802.1.
BC016137 mRNA. Translation: AAH16137.2.
D13645 mRNA. Translation: BAA02808.1. Different initiation.
AF490254 mRNA. Translation: AAO85462.1.
CR456957 mRNA. Translation: CAG33238.1.
AY047588 mRNA. Translation: AAL06072.1.
AY047589 mRNA. Translation: AAL06073.1.
AY047590 mRNA. Translation: AAL06074.1.
CCDSiCCDS6448.2.
RefSeqiNP_055693.4. NM_014878.4.
UniGeneiHs.493309.

Genome annotation databases

EnsembliENST00000397885; ENSP00000380982; ENSG00000080608.
GeneIDi9933.
KEGGihsa:9933.
UCSCiuc003zhp.1. human.

Polymorphism databases

DMDMi81175177.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AK292169 mRNA. Translation: BAF84858.1 .
AL354723 , AL589675 Genomic DNA. Translation: CAI15123.2 . Sequence problems.
AL589675 , AL354723 Genomic DNA. Translation: CAI12924.2 . Sequence problems.
CH471071 Genomic DNA. Translation: EAW58802.1 .
BC016137 mRNA. Translation: AAH16137.2 .
D13645 mRNA. Translation: BAA02808.1 . Different initiation.
AF490254 mRNA. Translation: AAO85462.1 .
CR456957 mRNA. Translation: CAG33238.1 .
AY047588 mRNA. Translation: AAL06072.1 .
AY047589 mRNA. Translation: AAL06073.1 .
AY047590 mRNA. Translation: AAL06074.1 .
CCDSi CCDS6448.2.
RefSeqi NP_055693.4. NM_014878.4.
UniGenei Hs.493309.

3D structure databases

ProteinModelPortali Q15397.
SMRi Q15397. Positions 166-464.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115259. 19 interactions.
IntActi Q15397. 3 interactions.
MINTi MINT-1404790.

PTM databases

PhosphoSitei Q15397.

Polymorphism databases

DMDMi 81175177.

2D gel databases

SWISS-2DPAGE Q15397.

Proteomic databases

MaxQBi Q15397.
PaxDbi Q15397.
PRIDEi Q15397.

Protocols and materials databases

DNASUi 9933.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000397885 ; ENSP00000380982 ; ENSG00000080608 .
GeneIDi 9933.
KEGGi hsa:9933.
UCSCi uc003zhp.1. human.

Organism-specific databases

CTDi 9933.
GeneCardsi GC09M002720.
HGNCi HGNC:29676. KIAA0020.
HPAi HPA002353.
MIMi 609960. gene.
neXtProti NX_Q15397.
PharmGKBi PA134895115.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG273657.
GeneTreei ENSGT00390000015757.
HOVERGENi HBG052166.
InParanoidi Q15397.
KOi K14844.
OMAi CLWHGTA.
OrthoDBi EOG783MV2.
PhylomeDBi Q15397.
TreeFami TF312954.

Miscellaneous databases

ChiTaRSi KIAA0020. human.
GeneWikii KIAA0020.
GenomeRNAii 9933.
NextBioi 37470.
SOURCEi Search...

Gene expression databases

Bgeei Q15397.
CleanExi HS_KIAA0020.
ExpressionAtlasi Q15397. baseline and differential.
Genevestigatori Q15397.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR012959. CPL.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view ]
Pfami PF08144. CPL. 1 hit.
[Graphical view ]
SMARTi SM00025. Pumilio. 6 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 2 hits.
PROSITEi PS50302. PUM. 5 hits.
PS50303. PUM_HD. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Synovium.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE HA-8R).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE HA-8PL), VARIANT ASN-13.
    Tissue: Uterus.
  5. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-648 (ALLELE HA-8R), TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  6. Bienvenut W.V.
    Submitted (AUG-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 130-137; 294-301; 331-342; 345-352 AND 441-464, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  7. "Cloning and identification of human gene 5 transactivated by hepatitis B virus X antigen."
    Liu Y., Cheng J., Lu Y., Wang G., Li K., Chen J., Li L.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 141-648 (ALLELE HA-8R).
  8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-648 (ALLELE HA-8R).
  9. "The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing."
    Brickner A.G., Warren E.H., Caldwell J.A., Akatsuka Y., Golovina T.N., Zarling A.L., Shabanowitz J., Eisenlohr L.C., Hunt D.F., Engelhard V.H., Riddell S.R.
    J. Exp. Med. 193:195-206(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 235-350 (ALLELES HA-8R; HA-8P AND HA-8PL), IDENTIFICATION BY MASS SPECTROMETRY OF HA-8.
    Tissue: B-cell.
  10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.

Entry informationi

Entry nameiK0020_HUMAN
AccessioniPrimary (citable) accession number: Q15397
Secondary accession number(s): A8K804
, Q547G7, Q5SZY9, Q6IB47, Q96B27, Q96L78, Q96L79, Q96L80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 8, 2005
Last modified: October 29, 2014
This is version 130 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3