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Q15397

- K0020_HUMAN

UniProt

Q15397 - K0020_HUMAN

Protein

Pumilio domain-containing protein KIAA0020

Gene

KIAA0020

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 129 (01 Oct 2014)
      Sequence version 3 (08 Nov 2005)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. poly(A) RNA binding Source: UniProtKB

    Keywords - Ligandi

    RNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pumilio domain-containing protein KIAA0020
    Alternative name(s):
    HBV X-transactivated gene 5 protein
    HBV XAg-transactivated protein 5
    Minor histocompatibility antigen HA-8
    Short name:
    HLA-HA8
    Gene namesi
    Name:KIAA0020
    Synonyms:XTP5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:29676. KIAA0020.

    Subcellular locationi

    Nucleusnucleolus 2 Publications

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB
    2. nucleolus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA134895115.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 648648Pumilio domain-containing protein KIAA0020PRO_0000075929Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei33 – 331N6-acetyllysineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ15397.
    PaxDbiQ15397.
    PRIDEiQ15397.

    2D gel databases

    SWISS-2DPAGEQ15397.

    PTM databases

    PhosphoSiteiQ15397.

    Expressioni

    Tissue specificityi

    Widely expressed.1 Publication

    Gene expression databases

    BgeeiQ15397.
    CleanExiHS_KIAA0020.
    GenevestigatoriQ15397.

    Organism-specific databases

    HPAiHPA002353.

    Interactioni

    Protein-protein interaction databases

    BioGridi115259. 9 interactions.
    IntActiQ15397. 3 interactions.
    MINTiMINT-1404790.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15397.
    SMRiQ15397. Positions 166-464.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini143 – 510368PUM-HDPROSITE-ProRule annotationAdd
    BLAST
    Repeati165 – 20036Pumilio 1Add
    BLAST
    Repeati201 – 23636Pumilio 2Add
    BLAST
    Repeati237 – 27337Pumilio 3Add
    BLAST
    Repeati350 – 38536Pumilio 4Add
    BLAST
    Repeati386 – 42237Pumilio 5Add
    BLAST
    Repeati424 – 46037Pumilio 6Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni289 – 2979HA-8

    Domaini

    The HA-8 region can be cleaved and exposed at the cell surface where it plays a role as a minor histocompatibility HLA-A*0201-restricted antigen.

    Sequence similaritiesi

    Contains 1 PUM-HD domain.PROSITE-ProRule annotation
    Contains 6 pumilio repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG273657.
    HOVERGENiHBG052166.
    InParanoidiQ15397.
    KOiK14844.
    OMAiCLWHGTA.
    OrthoDBiEOG783MV2.
    PhylomeDBiQ15397.
    TreeFamiTF312954.

    Family and domain databases

    Gene3Di1.25.10.10. 1 hit.
    InterProiIPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR012959. CPL.
    IPR001313. Pumilio_RNA-bd_rpt.
    [Graphical view]
    PfamiPF08144. CPL. 1 hit.
    [Graphical view]
    SMARTiSM00025. Pumilio. 6 hits.
    [Graphical view]
    SUPFAMiSSF48371. SSF48371. 2 hits.
    PROSITEiPS50302. PUM. 5 hits.
    PS50303. PUM_HD. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15397-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEVKGKKQFT GKSTKTAQEK NRFHKNSDSG SSKTFPTRKV AKEGGPKVTS    50
    RNFEKSITKL GKKGVKQFKN KQQGDKSPKN KFQPANKFNK KRKFQPDGRS 100
    DESAAKKPKW DDFKKKKKEL KQSRQLSDKT NYDIVVRAKQ MWEILRRKDC 150
    DKEKRVKLMS DLQKLIQGKI KTIAFAHDST RVIQCYIQYG NEEQRKQAFE 200
    ELRDDLVELS KAKYSRNIVK KFLMYGSKPQ IAEIIRSFKG HVRKMLRHAE 250
    ASAIVEYAYN DKAILEQRNM LTEELYGNTF QLYKSADHRT LDKVLEVQPE 300
    KLELIMDEMK QILTPMAQKE AVIKHSLVHK VFLDFFTYAP PKLRSEMIEA 350
    IREAVVYLAH THDGARVAMH CLWHGTPKDR KVIVKTMKTY VEKVANGQYS 400
    HLVLLAAFDC IDDTKLVKQI IISEIISSLP SIVNDKYGRK VLLYLLSPRD 450
    PAHTVREIIE VLQKGDGNAH SKKDTEVRRR ELLESISPAL LSYLQEHAQE 500
    VVLDKSACVL VSDILGSATG DVQPTMNAIA SLAATGLHPG GKDGELHIAE 550
    HPAGHLVLKW LIEQDKKMKE NGREGCFAKT LVEHVGMKNL KSWASVNRGA 600
    IILSSLLQSC DLEVANKVKA ALKSLIPTLE KTKSTSKGIE ILLEKLST 648
    Length:648
    Mass (Da):73,584
    Last modified:November 8, 2005 - v3
    Checksum:i449BFBF22F1BBA86
    GO

    Sequence cautioni

    The sequence BAA02808.1 differs from that shown. Reason: Erroneous initiation.
    The sequence CAI12924.2 differs from that shown. Reason: Erroneous gene model prediction.
    The sequence CAI15123.2 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti625 – 6251L → S in CAG33238. 1 PublicationCurated

    Polymorphismi

    The following alleles of HA-8 are known: HA-8R, HA-8P, HA-8PL, of which only HA-8R leads to specific cytotoxic T lymphocyte (CTL) recognition. The lack of CTL recognition of cells expressing HA-8P may be due to impaired transport associated with antigen processing. The sequence shown is that of HA-8R.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti13 – 131S → N.1 Publication
    Corresponds to variant rs10968457 [ dbSNP | Ensembl ].
    VAR_051613
    Natural varianti264 – 2641I → V.
    Corresponds to variant rs35869387 [ dbSNP | Ensembl ].
    VAR_051614
    Natural varianti289 – 2891R → P in allele HA-8P and allele HA-8PL.
    Corresponds to variant rs2173904 [ dbSNP | Ensembl ].
    VAR_023772
    Natural varianti297 – 2971V → L in allele HA-8PL.
    Corresponds to variant rs2270891 [ dbSNP | Ensembl ].
    VAR_023773
    Natural varianti414 – 4141T → S.
    Corresponds to variant rs3736390 [ dbSNP | Ensembl ].
    VAR_051615
    Natural varianti480 – 4801R → Q.
    Corresponds to variant rs2270889 [ dbSNP | Ensembl ].
    VAR_051616

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK292169 mRNA. Translation: BAF84858.1.
    AL354723, AL589675 Genomic DNA. Translation: CAI15123.2. Sequence problems.
    AL589675, AL354723 Genomic DNA. Translation: CAI12924.2. Sequence problems.
    CH471071 Genomic DNA. Translation: EAW58802.1.
    BC016137 mRNA. Translation: AAH16137.2.
    D13645 mRNA. Translation: BAA02808.1. Different initiation.
    AF490254 mRNA. Translation: AAO85462.1.
    CR456957 mRNA. Translation: CAG33238.1.
    AY047588 mRNA. Translation: AAL06072.1.
    AY047589 mRNA. Translation: AAL06073.1.
    AY047590 mRNA. Translation: AAL06074.1.
    CCDSiCCDS6448.2.
    RefSeqiNP_055693.4. NM_014878.4.
    UniGeneiHs.493309.

    Genome annotation databases

    EnsembliENST00000397885; ENSP00000380982; ENSG00000080608.
    GeneIDi9933.
    KEGGihsa:9933.
    UCSCiuc003zhp.1. human.

    Polymorphism databases

    DMDMi81175177.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AK292169 mRNA. Translation: BAF84858.1 .
    AL354723 , AL589675 Genomic DNA. Translation: CAI15123.2 . Sequence problems.
    AL589675 , AL354723 Genomic DNA. Translation: CAI12924.2 . Sequence problems.
    CH471071 Genomic DNA. Translation: EAW58802.1 .
    BC016137 mRNA. Translation: AAH16137.2 .
    D13645 mRNA. Translation: BAA02808.1 . Different initiation.
    AF490254 mRNA. Translation: AAO85462.1 .
    CR456957 mRNA. Translation: CAG33238.1 .
    AY047588 mRNA. Translation: AAL06072.1 .
    AY047589 mRNA. Translation: AAL06073.1 .
    AY047590 mRNA. Translation: AAL06074.1 .
    CCDSi CCDS6448.2.
    RefSeqi NP_055693.4. NM_014878.4.
    UniGenei Hs.493309.

    3D structure databases

    ProteinModelPortali Q15397.
    SMRi Q15397. Positions 166-464.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115259. 9 interactions.
    IntActi Q15397. 3 interactions.
    MINTi MINT-1404790.

    PTM databases

    PhosphoSitei Q15397.

    Polymorphism databases

    DMDMi 81175177.

    2D gel databases

    SWISS-2DPAGE Q15397.

    Proteomic databases

    MaxQBi Q15397.
    PaxDbi Q15397.
    PRIDEi Q15397.

    Protocols and materials databases

    DNASUi 9933.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397885 ; ENSP00000380982 ; ENSG00000080608 .
    GeneIDi 9933.
    KEGGi hsa:9933.
    UCSCi uc003zhp.1. human.

    Organism-specific databases

    CTDi 9933.
    GeneCardsi GC09M002720.
    HGNCi HGNC:29676. KIAA0020.
    HPAi HPA002353.
    MIMi 609960. gene.
    neXtProti NX_Q15397.
    PharmGKBi PA134895115.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG273657.
    HOVERGENi HBG052166.
    InParanoidi Q15397.
    KOi K14844.
    OMAi CLWHGTA.
    OrthoDBi EOG783MV2.
    PhylomeDBi Q15397.
    TreeFami TF312954.

    Miscellaneous databases

    ChiTaRSi KIAA0020. human.
    GeneWikii KIAA0020.
    GenomeRNAii 9933.
    NextBioi 37470.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q15397.
    CleanExi HS_KIAA0020.
    Genevestigatori Q15397.

    Family and domain databases

    Gene3Di 1.25.10.10. 1 hit.
    InterProi IPR011989. ARM-like.
    IPR016024. ARM-type_fold.
    IPR012959. CPL.
    IPR001313. Pumilio_RNA-bd_rpt.
    [Graphical view ]
    Pfami PF08144. CPL. 1 hit.
    [Graphical view ]
    SMARTi SM00025. Pumilio. 6 hits.
    [Graphical view ]
    SUPFAMi SSF48371. SSF48371. 2 hits.
    PROSITEi PS50302. PUM. 5 hits.
    PS50303. PUM_HD. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Synovium.
    2. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE HA-8R).
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE HA-8PL), VARIANT ASN-13.
      Tissue: Uterus.
    5. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-648 (ALLELE HA-8R), TISSUE SPECIFICITY.
      Tissue: Bone marrow.
    6. Bienvenut W.V.
      Submitted (AUG-2005) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 130-137; 294-301; 331-342; 345-352 AND 441-464, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    7. "Cloning and identification of human gene 5 transactivated by hepatitis B virus X antigen."
      Liu Y., Cheng J., Lu Y., Wang G., Li K., Chen J., Li L.
      Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 141-648 (ALLELE HA-8R).
    8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-648 (ALLELE HA-8R).
    9. "The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing."
      Brickner A.G., Warren E.H., Caldwell J.A., Akatsuka Y., Golovina T.N., Zarling A.L., Shabanowitz J., Eisenlohr L.C., Hunt D.F., Engelhard V.H., Riddell S.R.
      J. Exp. Med. 193:195-206(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 235-350 (ALLELES HA-8R; HA-8P AND HA-8PL), IDENTIFICATION BY MASS SPECTROMETRY OF HA-8.
      Tissue: B-cell.
    10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.

    Entry informationi

    Entry nameiK0020_HUMAN
    AccessioniPrimary (citable) accession number: Q15397
    Secondary accession number(s): A8K804
    , Q547G7, Q5SZY9, Q6IB47, Q96B27, Q96L78, Q96L79, Q96L80
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 8, 2005
    Last modified: October 1, 2014
    This is version 129 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3