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Protein

Pumilio domain-containing protein KIAA0020

Gene

KIAA0020

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • mRNA binding Source: GO_Central
  • poly(A) RNA binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Pumilio domain-containing protein KIAA0020
Alternative name(s):
HBV X-transactivated gene 5 protein
HBV XAg-transactivated protein 5
Minor histocompatibility antigen HA-8
Short name:
HLA-HA8
Gene namesi
Name:KIAA0020
Synonyms:PUF-A, XTP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:29676. KIAA0020.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: UniProtKB
  • nucleolus Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134895115.

Polymorphism and mutation databases

BioMutaiKIAA0020.
DMDMi81175177.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 648648Pumilio domain-containing protein KIAA0020PRO_0000075929Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei33 – 331N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ15397.
PaxDbiQ15397.
PRIDEiQ15397.

2D gel databases

SWISS-2DPAGEQ15397.

PTM databases

PhosphoSiteiQ15397.

Expressioni

Tissue specificityi

Widely expressed.1 Publication

Gene expression databases

BgeeiQ15397.
CleanExiHS_KIAA0020.
ExpressionAtlasiQ15397. baseline and differential.
GenevisibleiQ15397. HS.

Organism-specific databases

HPAiHPA002353.

Interactioni

Protein-protein interaction databases

BioGridi115259. 31 interactions.
IntActiQ15397. 5 interactions.
MINTiMINT-1404790.
STRINGi9606.ENSP00000380982.

Structurei

Secondary structure

1
648
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi132 – 14514Combined sources
Beta strandi147 – 1493Combined sources
Helixi152 – 16615Combined sources
Turni167 – 1693Combined sources
Helixi170 – 1756Combined sources
Turni177 – 1793Combined sources
Helixi180 – 18910Combined sources
Helixi192 – 20211Combined sources
Helixi203 – 2053Combined sources
Helixi206 – 2105Combined sources
Helixi213 – 22513Combined sources
Helixi228 – 23811Combined sources
Turni239 – 2413Combined sources
Helixi242 – 2454Combined sources
Helixi249 – 26113Combined sources
Helixi265 – 2728Combined sources
Helixi273 – 2764Combined sources
Helixi278 – 2836Combined sources
Beta strandi286 – 2883Combined sources
Helixi291 – 2977Combined sources
Helixi299 – 3013Combined sources
Helixi302 – 31312Combined sources
Helixi314 – 3185Combined sources
Helixi320 – 3234Combined sources
Helixi326 – 33813Combined sources
Helixi341 – 35111Combined sources
Turni352 – 3543Combined sources
Helixi355 – 3584Combined sources
Helixi362 – 37413Combined sources
Helixi377 – 38610Combined sources
Turni387 – 3904Combined sources
Helixi391 – 3955Combined sources
Turni398 – 4003Combined sources
Helixi401 – 41010Combined sources
Helixi414 – 42714Combined sources
Helixi429 – 4335Combined sources
Helixi436 – 44611Combined sources
Turni451 – 4533Combined sources
Helixi456 – 4638Combined sources
Turni464 – 4674Combined sources
Helixi475 – 49622Combined sources
Helixi498 – 5025Combined sources
Helixi507 – 5093Combined sources
Helixi510 – 5178Combined sources
Helixi523 – 5319Combined sources
Helixi548 – 5503Combined sources
Helixi554 – 57017Combined sources
Helixi577 – 5859Combined sources
Helixi587 – 5926Combined sources
Helixi593 – 5953Combined sources
Helixi597 – 60711Combined sources
Helixi612 – 62211Combined sources
Helixi623 – 6253Combined sources
Helixi626 – 6294Combined sources
Helixi637 – 6459Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4WZRX-ray2.15A/B123-648[»]
4WZWX-ray2.95A129-648[»]
ProteinModelPortaliQ15397.
SMRiQ15397. Positions 131-646.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 510368PUM-HDPROSITE-ProRule annotationAdd
BLAST
Repeati177 – 21236Pumilio 1Add
BLAST
Repeati213 – 24836Pumilio 2Add
BLAST
Repeati249 – 27729Pumilio 3Add
BLAST
Repeati289 – 32537Pumilio 4Add
BLAST
Repeati326 – 36136Pumilio 5Add
BLAST
Repeati362 – 39736Pumilio 6Add
BLAST
Repeati398 – 43538Pumilio 7Add
BLAST
Repeati436 – 50469Pumilio 8Add
BLAST
Repeati505 – 55147Pumilio 9Add
BLAST
Repeati552 – 59645Pumilio 10Add
BLAST
Repeati597 – 63640Pumilio 11Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni289 – 2979HA-8

Domaini

The HA-8 region can be cleaved and exposed at the cell surface where it plays a role as a minor histocompatibility HLA-A*0201-restricted antigen.
A 90 degree bend between Pumilio repeats 3 and 4 gives rise to a L-shaped protein.1 Publication

Sequence similaritiesi

Contains 1 PUM-HD domain.PROSITE-ProRule annotation
Contains 11 pumilio repeats.PROSITE-ProRule annotation1 Publication

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG273657.
GeneTreeiENSGT00390000015757.
HOVERGENiHBG052166.
InParanoidiQ15397.
KOiK14844.
OMAiKRTKLMS.
OrthoDBiEOG783MV2.
PhylomeDBiQ15397.
TreeFamiTF312954.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR012959. CPL.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
PfamiPF08144. CPL. 1 hit.
[Graphical view]
SMARTiSM00025. Pumilio. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50302. PUM. 5 hits.
PS50303. PUM_HD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15397-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEVKGKKQFT GKSTKTAQEK NRFHKNSDSG SSKTFPTRKV AKEGGPKVTS
60 70 80 90 100
RNFEKSITKL GKKGVKQFKN KQQGDKSPKN KFQPANKFNK KRKFQPDGRS
110 120 130 140 150
DESAAKKPKW DDFKKKKKEL KQSRQLSDKT NYDIVVRAKQ MWEILRRKDC
160 170 180 190 200
DKEKRVKLMS DLQKLIQGKI KTIAFAHDST RVIQCYIQYG NEEQRKQAFE
210 220 230 240 250
ELRDDLVELS KAKYSRNIVK KFLMYGSKPQ IAEIIRSFKG HVRKMLRHAE
260 270 280 290 300
ASAIVEYAYN DKAILEQRNM LTEELYGNTF QLYKSADHRT LDKVLEVQPE
310 320 330 340 350
KLELIMDEMK QILTPMAQKE AVIKHSLVHK VFLDFFTYAP PKLRSEMIEA
360 370 380 390 400
IREAVVYLAH THDGARVAMH CLWHGTPKDR KVIVKTMKTY VEKVANGQYS
410 420 430 440 450
HLVLLAAFDC IDDTKLVKQI IISEIISSLP SIVNDKYGRK VLLYLLSPRD
460 470 480 490 500
PAHTVREIIE VLQKGDGNAH SKKDTEVRRR ELLESISPAL LSYLQEHAQE
510 520 530 540 550
VVLDKSACVL VSDILGSATG DVQPTMNAIA SLAATGLHPG GKDGELHIAE
560 570 580 590 600
HPAGHLVLKW LIEQDKKMKE NGREGCFAKT LVEHVGMKNL KSWASVNRGA
610 620 630 640
IILSSLLQSC DLEVANKVKA ALKSLIPTLE KTKSTSKGIE ILLEKLST
Length:648
Mass (Da):73,584
Last modified:November 8, 2005 - v3
Checksum:i449BFBF22F1BBA86
GO

Sequence cautioni

The sequence BAA02808.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence CAI12924.2 differs from that shown. Reason: Erroneous gene model prediction. Curated
The sequence CAI15123.2 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti625 – 6251L → S in CAG33238 (Ref. 8) Curated

Polymorphismi

The following alleles of HA-8 are known: HA-8R, HA-8P, HA-8PL, of which only HA-8R leads to specific cytotoxic T lymphocyte (CTL) recognition. The lack of CTL recognition of cells expressing HA-8P may be due to impaired transport associated with antigen processing. The sequence shown is that of HA-8R.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti13 – 131S → N.1 Publication
Corresponds to variant rs10968457 [ dbSNP | Ensembl ].
VAR_051613
Natural varianti264 – 2641I → V.
Corresponds to variant rs35869387 [ dbSNP | Ensembl ].
VAR_051614
Natural varianti289 – 2891R → P in allele HA-8P and allele HA-8PL.
Corresponds to variant rs2173904 [ dbSNP | Ensembl ].
VAR_023772
Natural varianti297 – 2971V → L in allele HA-8PL.
Corresponds to variant rs2270891 [ dbSNP | Ensembl ].
VAR_023773
Natural varianti414 – 4141T → S.
Corresponds to variant rs3736390 [ dbSNP | Ensembl ].
VAR_051615
Natural varianti480 – 4801R → Q.
Corresponds to variant rs2270889 [ dbSNP | Ensembl ].
VAR_051616

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292169 mRNA. Translation: BAF84858.1.
AL354723, AL589675 Genomic DNA. Translation: CAI15123.2. Sequence problems.
AL589675, AL354723 Genomic DNA. Translation: CAI12924.2. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58802.1.
BC016137 mRNA. Translation: AAH16137.2.
D13645 mRNA. Translation: BAA02808.1. Different initiation.
AF490254 mRNA. Translation: AAO85462.1.
CR456957 mRNA. Translation: CAG33238.1.
AY047588 mRNA. Translation: AAL06072.1.
AY047589 mRNA. Translation: AAL06073.1.
AY047590 mRNA. Translation: AAL06074.1.
CCDSiCCDS6448.2.
RefSeqiNP_055693.4. NM_014878.4.
UniGeneiHs.493309.

Genome annotation databases

EnsembliENST00000397885; ENSP00000380982; ENSG00000080608.
GeneIDi9933.
KEGGihsa:9933.
UCSCiuc003zhp.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK292169 mRNA. Translation: BAF84858.1.
AL354723, AL589675 Genomic DNA. Translation: CAI15123.2. Sequence problems.
AL589675, AL354723 Genomic DNA. Translation: CAI12924.2. Sequence problems.
CH471071 Genomic DNA. Translation: EAW58802.1.
BC016137 mRNA. Translation: AAH16137.2.
D13645 mRNA. Translation: BAA02808.1. Different initiation.
AF490254 mRNA. Translation: AAO85462.1.
CR456957 mRNA. Translation: CAG33238.1.
AY047588 mRNA. Translation: AAL06072.1.
AY047589 mRNA. Translation: AAL06073.1.
AY047590 mRNA. Translation: AAL06074.1.
CCDSiCCDS6448.2.
RefSeqiNP_055693.4. NM_014878.4.
UniGeneiHs.493309.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4WZRX-ray2.15A/B123-648[»]
4WZWX-ray2.95A129-648[»]
ProteinModelPortaliQ15397.
SMRiQ15397. Positions 131-646.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115259. 31 interactions.
IntActiQ15397. 5 interactions.
MINTiMINT-1404790.
STRINGi9606.ENSP00000380982.

PTM databases

PhosphoSiteiQ15397.

Polymorphism and mutation databases

BioMutaiKIAA0020.
DMDMi81175177.

2D gel databases

SWISS-2DPAGEQ15397.

Proteomic databases

MaxQBiQ15397.
PaxDbiQ15397.
PRIDEiQ15397.

Protocols and materials databases

DNASUi9933.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000397885; ENSP00000380982; ENSG00000080608.
GeneIDi9933.
KEGGihsa:9933.
UCSCiuc003zhp.1. human.

Organism-specific databases

CTDi9933.
GeneCardsiGC09M002720.
HGNCiHGNC:29676. KIAA0020.
HPAiHPA002353.
MIMi609960. gene.
neXtProtiNX_Q15397.
PharmGKBiPA134895115.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG273657.
GeneTreeiENSGT00390000015757.
HOVERGENiHBG052166.
InParanoidiQ15397.
KOiK14844.
OMAiKRTKLMS.
OrthoDBiEOG783MV2.
PhylomeDBiQ15397.
TreeFamiTF312954.

Miscellaneous databases

ChiTaRSiKIAA0020. human.
GeneWikiiKIAA0020.
GenomeRNAii9933.
NextBioi37470.
PROiQ15397.
SOURCEiSearch...

Gene expression databases

BgeeiQ15397.
CleanExiHS_KIAA0020.
ExpressionAtlasiQ15397. baseline and differential.
GenevisibleiQ15397. HS.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR012959. CPL.
IPR001313. Pumilio_RNA-bd_rpt.
[Graphical view]
PfamiPF08144. CPL. 1 hit.
[Graphical view]
SMARTiSM00025. Pumilio. 6 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 2 hits.
PROSITEiPS50302. PUM. 5 hits.
PS50303. PUM_HD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Synovium.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (ALLELE HA-8R).
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ALLELE HA-8PL), VARIANT ASN-13.
    Tissue: Uterus.
  5. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-648 (ALLELE HA-8R), TISSUE SPECIFICITY.
    Tissue: Bone marrow.
  6. Bienvenut W.V.
    Submitted (AUG-2005) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 130-137; 294-301; 331-342; 345-352 AND 441-464, SUBCELLULAR LOCATION, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  7. "Cloning and identification of human gene 5 transactivated by hepatitis B virus X antigen."
    Liu Y., Cheng J., Lu Y., Wang G., Li K., Chen J., Li L.
    Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 141-648 (ALLELE HA-8R).
  8. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 141-648 (ALLELE HA-8R).
  9. "The immunogenicity of a new human minor histocompatibility antigen results from differential antigen processing."
    Brickner A.G., Warren E.H., Caldwell J.A., Akatsuka Y., Golovina T.N., Zarling A.L., Shabanowitz J., Eisenlohr L.C., Hunt D.F., Engelhard V.H., Riddell S.R.
    J. Exp. Med. 193:195-206(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 235-350 (ALLELES HA-8R; HA-8P AND HA-8PL), IDENTIFICATION BY MASS SPECTROMETRY OF HA-8.
    Tissue: B-cell.
  10. Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "A divergent Pumilio repeat protein family for pre-rRNA processing and mRNA localization."
    Qiu C., McCann K.L., Wine R.N., Baserga S.J., Hall T.M.
    Proc. Natl. Acad. Sci. U.S.A. 111:18554-18559(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 123-648 ALONE AND IN COMPLEX WITH DOUBLE-STRANDED DNA, PUMILIO REPEATS, RNA-BINDING, DNA-BINDING.

Entry informationi

Entry nameiK0020_HUMAN
AccessioniPrimary (citable) accession number: Q15397
Secondary accession number(s): A8K804
, Q547G7, Q5SZY9, Q6IB47, Q96B27, Q96L78, Q96L79, Q96L80
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 8, 2005
Last modified: July 22, 2015
This is version 138 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds to double-stranded RNA or DNA without sequence specificity.1 Publication

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.