ID   P2Y14_HUMAN             Reviewed;         338 AA.
AC   Q15391; Q8IYT7;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   11-NOV-2015, entry version 140.
DE   RecName: Full=P2Y purinoceptor 14;
DE            Short=P2Y14;
DE   AltName: Full=G-protein coupled receptor 105;
DE   AltName: Full=UDP-glucose receptor;
GN   Name=P2RY14; Synonyms=GPR105, KIAA0001;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=11524702; DOI=10.1086/323610;
RA   Joensuu T., Haemaelaeinen R., Yuan B., Johnson C., Tegelberg S.,
RA   Gasparini P., Zelante L., Pirvola U., Pakarinen L., Lehesjoki A.-E.,
RA   de la Chapelle A., Sankila E.-M.;
RT   "Mutations in a novel gene with transmembrane domains underlie Usher
RT   syndrome type 3.";
RL   Am. J. Hum. Genet. 69:673-684(2001).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Bone marrow;
RX   PubMed=7584026; DOI=10.1093/dnares/1.1.27;
RA   Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y.,
RA   Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.;
RT   "Prediction of the coding sequences of unidentified human genes. I.
RT   The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by
RT   analysis of randomly sampled cDNA clones from human immature myeloid
RT   cell line KG-1.";
RL   DNA Res. 1:27-35(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   FUNCTION.
RX   PubMed=10753868; DOI=10.1074/jbc.275.15.10767;
RA   Chambers J.K., Macdonald L.E., Sarau H.M., Ames R.S., Freeman K.,
RA   Foley J.J., Zhu Y., McLaughlin M.M., Murdock P., McMillan L.,
RA   Trill J., Swift A., Aiyar N., Taylor P., Vawter L., Naheed S.,
RA   Szekeres P., Hervieu G., Scott C., Watson J.M., Murphy A.J., Duzic E.,
RA   Klein C., Bergsma D.J., Wilson S., Livi G.P.;
RT   "A G protein-coupled receptor for UDP-glucose.";
RL   J. Biol. Chem. 275:10767-10771(2000).
RN   [5]
RP   VARIANT [LARGE SCALE ANALYSIS] PRO-140.
RX   PubMed=16959974; DOI=10.1126/science.1133427;
RA   Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA   Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S.,
RA   Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J.,
RA   Dawson D., Willson J.K.V., Gazdar A.F., Hartigan J., Wu L., Liu C.,
RA   Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N.,
RA   Vogelstein B., Kinzler K.W., Velculescu V.E.;
RT   "The consensus coding sequences of human breast and colorectal
RT   cancers.";
RL   Science 314:268-274(2006).
CC   -!- FUNCTION: Receptor for UDP-glucose and other UDP-sugar coupled to
CC       G-proteins. Not activated by ATP, ADP, UTP or ATP.
CC       {ECO:0000269|PubMed:10753868}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC   -!- TISSUE SPECIFICITY: Highest expression in the placenta, adipose
CC       tissue, stomach and intestine, intermediate levels in the brain,
CC       spleen, lung and heart, lowest levels in the kidney.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA02791.2; Type=Erroneous initiation; Evidence={ECO:0000305};
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF456925; AAL47764.1; -; Genomic_DNA.
DR   EMBL; D13626; BAA02791.2; ALT_INIT; mRNA.
DR   EMBL; BC034989; AAH34989.1; -; mRNA.
DR   CCDS; CCDS3156.1; -.
DR   RefSeq; NP_001074924.1; NM_001081455.1.
DR   RefSeq; NP_055694.3; NM_014879.3.
DR   RefSeq; XP_005247979.1; XM_005247922.3.
DR   RefSeq; XP_005247980.1; XM_005247923.2.
DR   RefSeq; XP_011511642.1; XM_011513340.1.
DR   UniGene; Hs.2465; -.
DR   PDB; 2B6V; Model; -; A=1-338.
DR   PDBsum; 2B6V; -.
DR   ProteinModelPortal; Q15391; -.
DR   SMR; Q15391; 14-310.
DR   BioGrid; 115260; 3.
DR   STRING; 9606.ENSP00000308361; -.
DR   BindingDB; Q15391; -.
DR   ChEMBL; CHEMBL4518; -.
DR   GuidetoPHARMACOLOGY; 330; -.
DR   PhosphoSite; Q15391; -.
DR   BioMuta; P2RY14; -.
DR   DMDM; 3122322; -.
DR   PaxDb; Q15391; -.
DR   PRIDE; Q15391; -.
DR   Ensembl; ENST00000309170; ENSP00000308361; ENSG00000174944.
DR   Ensembl; ENST00000424796; ENSP00000408733; ENSG00000174944.
DR   GeneID; 9934; -.
DR   KEGG; hsa:9934; -.
DR   UCSC; uc003eyr.1; human.
DR   CTD; 9934; -.
DR   GeneCards; P2RY14; -.
DR   HGNC; HGNC:16442; P2RY14.
DR   HPA; CAB022646; -.
DR   HPA; HPA030398; -.
DR   MIM; 610116; gene.
DR   neXtProt; NX_Q15391; -.
DR   PharmGKB; PA28853; -.
DR   eggNOG; ENOG410IK1E; Eukaryota.
DR   eggNOG; ENOG4111GWF; LUCA.
DR   GeneTree; ENSGT00640000091213; -.
DR   HOGENOM; HOG000273884; -.
DR   HOVERGEN; HBG108228; -.
DR   InParanoid; Q15391; -.
DR   KO; K04299; -.
DR   OMA; WHKASNY; -.
DR   OrthoDB; EOG7JX34K; -.
DR   PhylomeDB; Q15391; -.
DR   TreeFam; TF330969; -.
DR   Reactome; R-HSA-417957; P2Y receptors.
DR   Reactome; R-HSA-418594; G alpha (i) signalling events.
DR   GenomeRNAi; 9934; -.
DR   NextBio; 37474; -.
DR   PRO; PR:Q15391; -.
DR   Proteomes; UP000005640; Chromosome 3.
DR   Bgee; Q15391; -.
DR   CleanEx; HS_P2RY14; -.
DR   ExpressionAtlas; Q15391; baseline and differential.
DR   Genevisible; Q15391; HS.
DR   GO; GO:0016021; C:integral component of membrane; NAS:UniProtKB.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0045028; F:G-protein coupled purinergic nucleotide receptor activity; IBA:GO_Central.
DR   GO; GO:0045029; F:UDP-activated nucleotide receptor activity; NAS:UniProtKB.
DR   GO; GO:0035589; P:G-protein coupled purinergic nucleotide receptor signaling pathway; IBA:GOC.
DR   GO; GO:0007186; P:G-protein coupled receptor signaling pathway; NAS:UniProtKB.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR005466; P2Y14_rcpt.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR01655; UDPGLUCOSER.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   2: Evidence at transcript level;
KW   3D-structure; Cell membrane; Complete proteome; Disulfide bond;
KW   G-protein coupled receptor; Glycoprotein; Membrane; Polymorphism;
KW   Receptor; Reference proteome; Transducer; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN         1    338       P2Y purinoceptor 14.
FT                                /FTId=PRO_0000070044.
FT   TOPO_DOM      1     29       Extracellular. {ECO:0000255}.
FT   TRANSMEM     30     50       Helical; Name=1. {ECO:0000255}.
FT   TOPO_DOM     51     55       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM     56     76       Helical; Name=2. {ECO:0000255}.
FT   TOPO_DOM     77     96       Extracellular. {ECO:0000255}.
FT   TRANSMEM     97    117       Helical; Name=3. {ECO:0000255}.
FT   TOPO_DOM    118    139       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    140    160       Helical; Name=4. {ECO:0000255}.
FT   TOPO_DOM    161    188       Extracellular. {ECO:0000255}.
FT   TRANSMEM    189    209       Helical; Name=5. {ECO:0000255}.
FT   TOPO_DOM    210    234       Cytoplasmic. {ECO:0000255}.
FT   TRANSMEM    235    255       Helical; Name=6. {ECO:0000255}.
FT   TOPO_DOM    256    278       Extracellular. {ECO:0000255}.
FT   TRANSMEM    279    299       Helical; Name=7. {ECO:0000255}.
FT   TOPO_DOM    300    338       Cytoplasmic. {ECO:0000255}.
FT   CARBOHYD      3      3       N-linked (GlcNAc...). {ECO:0000255}.
FT   CARBOHYD    161    161       N-linked (GlcNAc...). {ECO:0000255}.
FT   DISULFID     94    172       {ECO:0000255|PROSITE-ProRule:PRU00521}.
FT   VARIANT     140    140       L -> P (in a colorectal cancer sample;
FT                                somatic mutation).
FT                                {ECO:0000269|PubMed:16959974}.
FT                                /FTId=VAR_035767.
FT   CONFLICT     54     54       K -> E (in Ref. 3; AAH34989).
FT                                {ECO:0000305}.
SQ   SEQUENCE   338 AA;  38971 MW;  8DBE7C782CB4753D CRC64;
     MINSTSTQPP DESCSQNLLI TQQIIPVLYC MVFIAGILLN GVSGWIFFYV PSSKSFIIYL
     KNIVIADFVM SLTFPFKILG DSGLGPWQLN VFVCRVSAVL FYVNMYVSIV FFGLISFDRY
     YKIVKPLWTS FIQSVSYSKL LSVIVWMLML LLAVPNIILT NQSVREVTQI KCIELKSELG
     RKWHKASNYI FVAIFWIVFL LLIVFYTAIT KKIFKSHLKS SRNSTSVKKK SSRNIFSIVF
     VFFVCFVPYH IARIPYTKSQ TEAHYSCQSK EILRYMKEFT LLLSAANVCL DPIIYFFLCQ
     PFREILCKKL HIPLKAQNDL DISRIKRGNT TLESTDTL
//