P2Y purinoceptor 14 - Homo sapiens (Human)

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Q15391 (P2Y14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 104. History...

Clusters with 100%, 90%, 50% identity |

Documents (7) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
P2Y purinoceptor 14
Short name=P2Y14

Alternative name(s):
G-protein coupled receptor 105
UDP-glucose receptor

Gene names

Name:	P2RY14
Synonyms:	GPR105, KIAA0001

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	338 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP. Ref.4
Subcellular location	Cell membrane; Multi-pass membrane protein.
Tissue specificity	Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.
Sequence similarities	Belongs to the G-protein coupled receptor 1 family.
Sequence caution	The sequence BAA02791.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane Transmembrane helix
Molecular function	G-protein coupled receptor Receptor Transducer
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	integral to membrane Non-traceable author statement Ref.4. Source: UniProtKB plasma membrane Traceable author statement. Source: Reactome
Molecular function	G-protein coupled purinergic nucleotide receptor activity Inferred from electronic annotation. Source: InterPro UDP-activated nucleotide receptor activity Non-traceable author statement Ref.4. Source: UniProtKB
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 338

338

P2Y purinoceptor 14

PRO_0000070044

Regions

Topological domain

1 – 29

Extracellular Potential

Transmembrane

30 – 50

Helical; Name=1; Potential

Topological domain

51 – 55

Cytoplasmic Potential

Transmembrane

56 – 76

Helical; Name=2; Potential

Topological domain

77 – 96

Extracellular Potential

Transmembrane

97 – 117

Helical; Name=3; Potential

Topological domain

118 – 139

Cytoplasmic Potential

Transmembrane

140 – 160

Helical; Name=4; Potential

Topological domain

161 – 188

Extracellular Potential

Transmembrane

189 – 209

Helical; Name=5; Potential

Topological domain

210 – 234

Cytoplasmic Potential

Transmembrane

235 – 255

Helical; Name=6; Potential

Topological domain

256 – 278

Extracellular Potential

Transmembrane

279 – 299

Helical; Name=7; Potential

Topological domain

300 – 338

Cytoplasmic Potential

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

161

N-linked (GlcNAc...) Potential

Disulfide bond

94 ↔ 172

By similarity

Natural variations

Natural variant

140

L → P in a colorectal cancer sample; somatic mutation. Ref.5

VAR_035767

Experimental info

Sequence conflict

K → E in AAH34989. Ref.3

Sequences

Sequence

Length

Mass (Da)

Tools

Q15391 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8DBE7C782CB4753D
Show »

FASTA

338

38,971

        10         20         30         40         50         60 
MINSTSTQPP DESCSQNLLI TQQIIPVLYC MVFIAGILLN GVSGWIFFYV PSSKSFIIYL 

        70         80         90        100        110        120 
KNIVIADFVM SLTFPFKILG DSGLGPWQLN VFVCRVSAVL FYVNMYVSIV FFGLISFDRY 

       130        140        150        160        170        180 
YKIVKPLWTS FIQSVSYSKL LSVIVWMLML LLAVPNIILT NQSVREVTQI KCIELKSELG 

       190        200        210        220        230        240 
RKWHKASNYI FVAIFWIVFL LLIVFYTAIT KKIFKSHLKS SRNSTSVKKK SSRNIFSIVF 

       250        260        270        280        290        300 
VFFVCFVPYH IARIPYTKSQ TEAHYSCQSK EILRYMKEFT LLLSAANVCL DPIIYFFLCQ 

       310        320        330 
PFREILCKKL HIPLKAQNDL DISRIKRGNT TLESTDTL

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3." Joensuu T., Haemaelaeinen R., Yuan B., Johnson C., Tegelberg S., Gasparini P., Zelante L., Pirvola U., Pakarinen L., Lehesjoki A.-E., de la Chapelle A., Sankila E.-M. Am. J. Hum. Genet. 69:673-684(2001) [PubMed: 11524702] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed: 7584026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[3]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Testis.
[4]	"A G protein-coupled receptor for UDP-glucose." Chambers J.K., Macdonald L.E., Sarau H.M., Ames R.S., Freeman K., Foley J.J., Zhu Y., McLaughlin M.M., Murdock P., McMillan L., Trill J., Swift A., Aiyar N., Taylor P., Vawter L., Naheed S., Szekeres P., Hervieu G. Livi G.P. J. Biol. Chem. 275:10767-10771(2000) [PubMed: 10753868] [Abstract] Cited for: FUNCTION.
[5]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-140.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AF456925 Genomic DNA. Translation: AAL47764.1.
D13626 mRNA. Translation: BAA02791.2. Different initiation.
BC034989 mRNA. Translation: AAH34989.1.

IPI

IPI00016701.

RefSeq

NP_001074924.1. NM_001081455.1.
NP_055694.3. NM_014879.3.

UniGene

Hs.2465.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2B6V	model	-	A	1-338	[»]

ProteinModelPortal

Q15391.

SMR

Q15391. Positions 107-137, 278-313.

ModBase

Search...

Protein-protein interaction databases

STRING

Q15391.

Protein family/group databases

GPCRDB

Search...

PTM databases

PhosphoSite

Q15391.

Polymorphism databases

DMDM

3122322.

Proteomic databases

PRIDE

Q15391.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000309170; ENSP00000308361; ENSG00000174944.
ENST00000424796; ENSP00000408733; ENSG00000174944.

GeneID

9934.

KEGG

hsa:9934.

UCSC

uc003eyr.1. human.

Organism-specific databases

CTD

9934.

GeneCards

GC03M150929.

H-InvDB

HIX0003777.

HGNC

HGNC:16442. P2RY14.

HPA

CAB022646.

MIM

610116. gene.

neXtProt

NX_Q15391.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG08930.

GeneTree

ENSGT00550000074295.

HOGENOM

HBG444381.

HOVERGEN

HBG108228.

InParanoid

Q15391.

OMA

MSLTFPF.

OrthoDB

EOG4FXR8H.

PhylomeDB

Q15391.

Enzyme and pathway databases

Reactome

REACT_111102. Signal Transduction.

Gene expression databases

ArrayExpress

Q15391.

Bgee

Q15391.

CleanEx

HS_P2RY14.

Genevestigator

Q15391.

GermOnline

ENSG00000174944. Homo sapiens.

Family and domain databases

InterPro

IPR000276. 7TM_GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_supfam.
IPR002286. P2_purnocptor.
IPR005466. UDPG_rcpt.
[Graphical view]

K04299.

Pfam

PF00001. 7tm_1. 1 hit.
[Graphical view]

PRINTS

PR00237. GPCRRHODOPSN.
PR01157. P2YPURNOCPTR.
PR01655. UDPGLUCOSER.

PROSITE

PS00237. G_PROTEIN_RECEP_F1_1. False negative.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

NextBio

37474.

SOURCE

Search...

Entry information

Entry name

P2Y14_HUMAN

Accession

Primary (citable) accession number: Q15391
Secondary accession number(s): Q8IYT7

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.