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Q15391

- P2Y14_HUMAN

UniProt

Q15391 - P2Y14_HUMAN

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Protein

P2Y purinoceptor 14

Gene

P2RY14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.1 Publication

GO - Molecular functioni

  1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
  2. UDP-activated nucleotide receptor activity Source: UniProtKB

GO - Biological processi

  1. G-protein coupled receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_18289. P2Y receptors.
REACT_19231. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 14
Short name:
P2Y14
Alternative name(s):
G-protein coupled receptor 105
UDP-glucose receptor
Gene namesi
Name:P2RY14
Synonyms:GPR105, KIAA0001
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:16442. P2RY14.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA28853.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 338338P2Y purinoceptor 14PRO_0000070044Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15391.
PRIDEiQ15391.

PTM databases

PhosphoSiteiQ15391.

Expressioni

Tissue specificityi

Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.

Gene expression databases

BgeeiQ15391.
CleanExiHS_P2RY14.
ExpressionAtlasiQ15391. baseline and differential.
GenevestigatoriQ15391.

Organism-specific databases

HPAiCAB022646.

Interactioni

Protein-protein interaction databases

BioGridi115260. 3 interactions.
STRINGi9606.ENSP00000308361.

Structurei

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Vmodel-A1-338[»]
ProteinModelPortaliQ15391.
SMRiQ15391. Positions 14-310.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
BLAST
Topological domaini51 – 555CytoplasmicSequence Analysis
Topological domaini77 – 9620ExtracellularSequence AnalysisAdd
BLAST
Topological domaini118 – 13922CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini161 – 18828ExtracellularSequence AnalysisAdd
BLAST
Topological domaini210 – 23425CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini256 – 27823ExtracellularSequence AnalysisAdd
BLAST
Topological domaini300 – 33839CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei97 – 11721Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei279 – 29921Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149084.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ15391.
KOiK04299.
OMAiFLCQPFR.
OrthoDBiEOG7JX34K.
PhylomeDBiQ15391.
TreeFamiTF330969.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005466. P2Y14_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01655. UDPGLUCOSER.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15391 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MINSTSTQPP DESCSQNLLI TQQIIPVLYC MVFIAGILLN GVSGWIFFYV
60 70 80 90 100
PSSKSFIIYL KNIVIADFVM SLTFPFKILG DSGLGPWQLN VFVCRVSAVL
110 120 130 140 150
FYVNMYVSIV FFGLISFDRY YKIVKPLWTS FIQSVSYSKL LSVIVWMLML
160 170 180 190 200
LLAVPNIILT NQSVREVTQI KCIELKSELG RKWHKASNYI FVAIFWIVFL
210 220 230 240 250
LLIVFYTAIT KKIFKSHLKS SRNSTSVKKK SSRNIFSIVF VFFVCFVPYH
260 270 280 290 300
IARIPYTKSQ TEAHYSCQSK EILRYMKEFT LLLSAANVCL DPIIYFFLCQ
310 320 330
PFREILCKKL HIPLKAQNDL DISRIKRGNT TLESTDTL
Length:338
Mass (Da):38,971
Last modified:November 1, 1996 - v1
Checksum:i8DBE7C782CB4753D
GO

Sequence cautioni

The sequence BAA02791.2 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti54 – 541K → E in AAH34989. (PubMed:15489334)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti140 – 1401L → P in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035767

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF456925 Genomic DNA. Translation: AAL47764.1.
D13626 mRNA. Translation: BAA02791.2. Different initiation.
BC034989 mRNA. Translation: AAH34989.1.
CCDSiCCDS3156.1.
RefSeqiNP_001074924.1. NM_001081455.1.
NP_055694.3. NM_014879.3.
XP_005247978.1. XM_005247921.1.
XP_005247979.1. XM_005247922.2.
XP_005247980.1. XM_005247923.1.
XP_006713895.1. XM_006713832.1.
UniGeneiHs.2465.

Genome annotation databases

EnsembliENST00000309170; ENSP00000308361; ENSG00000174944.
ENST00000424796; ENSP00000408733; ENSG00000174944.
GeneIDi9934.
KEGGihsa:9934.
UCSCiuc003eyr.1. human.

Polymorphism databases

DMDMi3122322.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF456925 Genomic DNA. Translation: AAL47764.1 .
D13626 mRNA. Translation: BAA02791.2 . Different initiation.
BC034989 mRNA. Translation: AAH34989.1 .
CCDSi CCDS3156.1.
RefSeqi NP_001074924.1. NM_001081455.1.
NP_055694.3. NM_014879.3.
XP_005247978.1. XM_005247921.1.
XP_005247979.1. XM_005247922.2.
XP_005247980.1. XM_005247923.1.
XP_006713895.1. XM_006713832.1.
UniGenei Hs.2465.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2B6V model - A 1-338 [» ]
ProteinModelPortali Q15391.
SMRi Q15391. Positions 14-310.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115260. 3 interactions.
STRINGi 9606.ENSP00000308361.

Chemistry

BindingDBi Q15391.
ChEMBLi CHEMBL4518.
GuidetoPHARMACOLOGYi 330.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q15391.

Polymorphism databases

DMDMi 3122322.

Proteomic databases

PaxDbi Q15391.
PRIDEi Q15391.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000309170 ; ENSP00000308361 ; ENSG00000174944 .
ENST00000424796 ; ENSP00000408733 ; ENSG00000174944 .
GeneIDi 9934.
KEGGi hsa:9934.
UCSCi uc003eyr.1. human.

Organism-specific databases

CTDi 9934.
GeneCardsi GC03M150929.
HGNCi HGNC:16442. P2RY14.
HPAi CAB022646.
MIMi 610116. gene.
neXtProti NX_Q15391.
PharmGKBi PA28853.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149084.
GeneTreei ENSGT00640000091213.
HOGENOMi HOG000273884.
HOVERGENi HBG108228.
InParanoidi Q15391.
KOi K04299.
OMAi FLCQPFR.
OrthoDBi EOG7JX34K.
PhylomeDBi Q15391.
TreeFami TF330969.

Enzyme and pathway databases

Reactomei REACT_18289. P2Y receptors.
REACT_19231. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii 9934.
NextBioi 37474.
PROi Q15391.
SOURCEi Search...

Gene expression databases

Bgeei Q15391.
CleanExi HS_P2RY14.
ExpressionAtlasi Q15391. baseline and differential.
Genevestigatori Q15391.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005466. P2Y14_rcpt.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR00237. GPCRRHODOPSN.
PR01655. UDPGLUCOSER.
PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
    Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
    DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Testis.
  4. Cited for: FUNCTION.
  5. Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-140.

Entry informationi

Entry nameiP2Y14_HUMAN
AccessioniPrimary (citable) accession number: Q15391
Secondary accession number(s): Q8IYT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: October 29, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3