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Q15391 (P2Y14_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 128. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
P2Y purinoceptor 14

Short name=P2Y14
Alternative name(s):
G-protein coupled receptor 105
UDP-glucose receptor
Gene names
Name:P2RY14
Synonyms:GPR105, KIAA0001
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length338 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP. Ref.4

Subcellular location

Cell membrane; Multi-pass membrane protein.

Tissue specificity

Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence BAA02791.2 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 338338P2Y purinoceptor 14
PRO_0000070044

Regions

Topological domain1 – 2929Extracellular Potential
Transmembrane30 – 5021Helical; Name=1; Potential
Topological domain51 – 555Cytoplasmic Potential
Transmembrane56 – 7621Helical; Name=2; Potential
Topological domain77 – 9620Extracellular Potential
Transmembrane97 – 11721Helical; Name=3; Potential
Topological domain118 – 13922Cytoplasmic Potential
Transmembrane140 – 16021Helical; Name=4; Potential
Topological domain161 – 18828Extracellular Potential
Transmembrane189 – 20921Helical; Name=5; Potential
Topological domain210 – 23425Cytoplasmic Potential
Transmembrane235 – 25521Helical; Name=6; Potential
Topological domain256 – 27823Extracellular Potential
Transmembrane279 – 29921Helical; Name=7; Potential
Topological domain300 – 33839Cytoplasmic Potential

Amino acid modifications

Glycosylation31N-linked (GlcNAc...) Potential
Glycosylation1611N-linked (GlcNAc...) Potential
Disulfide bond94 ↔ 172 By similarity

Natural variations

Natural variant1401L → P in a colorectal cancer sample; somatic mutation. Ref.5
VAR_035767

Experimental info

Sequence conflict541K → E in AAH34989. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q15391 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8DBE7C782CB4753D

FASTA33838,971
        10         20         30         40         50         60 
MINSTSTQPP DESCSQNLLI TQQIIPVLYC MVFIAGILLN GVSGWIFFYV PSSKSFIIYL 

        70         80         90        100        110        120 
KNIVIADFVM SLTFPFKILG DSGLGPWQLN VFVCRVSAVL FYVNMYVSIV FFGLISFDRY 

       130        140        150        160        170        180 
YKIVKPLWTS FIQSVSYSKL LSVIVWMLML LLAVPNIILT NQSVREVTQI KCIELKSELG 

       190        200        210        220        230        240 
RKWHKASNYI FVAIFWIVFL LLIVFYTAIT KKIFKSHLKS SRNSTSVKKK SSRNIFSIVF 

       250        260        270        280        290        300 
VFFVCFVPYH IARIPYTKSQ TEAHYSCQSK EILRYMKEFT LLLSAANVCL DPIIYFFLCQ 

       310        320        330 
PFREILCKKL HIPLKAQNDL DISRIKRGNT TLESTDTL 

« Hide

References

« Hide 'large scale' references
[1]"Mutations in a novel gene with transmembrane domains underlie Usher syndrome type 3."
Joensuu T., Haemaelaeinen R., Yuan B., Johnson C., Tegelberg S., Gasparini P., Zelante L., Pirvola U., Pakarinen L., Lehesjoki A.-E., de la Chapelle A., Sankila E.-M.
Am. J. Hum. Genet. 69:673-684(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Bone marrow.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Testis.
[4]"A G protein-coupled receptor for UDP-glucose."
Chambers J.K., Macdonald L.E., Sarau H.M., Ames R.S., Freeman K., Foley J.J., Zhu Y., McLaughlin M.M., Murdock P., McMillan L., Trill J., Swift A., Aiyar N., Taylor P., Vawter L., Naheed S., Szekeres P., Hervieu G. expand/collapse author list , Scott C., Watson J.M., Murphy A.J., Duzic E., Klein C., Bergsma D.J., Wilson S., Livi G.P.
J. Biol. Chem. 275:10767-10771(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION.
[5]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-140.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF456925 Genomic DNA. Translation: AAL47764.1.
D13626 mRNA. Translation: BAA02791.2. Different initiation.
BC034989 mRNA. Translation: AAH34989.1.
CCDSCCDS3156.1.
RefSeqNP_001074924.1. NM_001081455.1.
NP_055694.3. NM_014879.3.
XP_005247978.1. XM_005247921.1.
XP_005247979.1. XM_005247922.2.
XP_005247980.1. XM_005247923.1.
XP_006713895.1. XM_006713832.1.
UniGeneHs.2465.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2B6Vmodel-A1-338[»]
ProteinModelPortalQ15391.
SMRQ15391. Positions 14-309.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000308361.

Chemistry

BindingDBQ15391.
ChEMBLCHEMBL4518.
GuidetoPHARMACOLOGY330.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ15391.

Polymorphism databases

DMDM3122322.

Proteomic databases

PaxDbQ15391.
PRIDEQ15391.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000309170; ENSP00000308361; ENSG00000174944.
ENST00000424796; ENSP00000408733; ENSG00000174944.
GeneID9934.
KEGGhsa:9934.
UCSCuc003eyr.1. human.

Organism-specific databases

CTD9934.
GeneCardsGC03M150929.
HGNCHGNC:16442. P2RY14.
HPACAB022646.
MIM610116. gene.
neXtProtNX_Q15391.
PharmGKBPA28853.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG149084.
HOGENOMHOG000273884.
HOVERGENHBG108228.
InParanoidQ15391.
KOK04299.
OMAFLCQPFR.
OrthoDBEOG7JX34K.
PhylomeDBQ15391.
TreeFamTF330969.

Enzyme and pathway databases

ReactomeREACT_111102. Signal Transduction.

Gene expression databases

ArrayExpressQ15391.
BgeeQ15391.
CleanExHS_P2RY14.
GenevestigatorQ15391.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005466. P2Y14_rcpt.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR00237. GPCRRHODOPSN.
PR01655. UDPGLUCOSER.
PROSITEPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi9934.
NextBio37474.
PROQ15391.
SOURCESearch...

Entry information

Entry nameP2Y14_HUMAN
AccessionPrimary (citable) accession number: Q15391
Secondary accession number(s): Q8IYT7
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: July 9, 2014
This is version 128 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries