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Q15391

- P2Y14_HUMAN

UniProt

Q15391 - P2Y14_HUMAN

Protein

P2Y purinoceptor 14

Gene

P2RY14

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.1 Publication

    GO - Molecular functioni

    1. G-protein coupled purinergic nucleotide receptor activity Source: InterPro
    2. UDP-activated nucleotide receptor activity Source: UniProtKB

    GO - Biological processi

    1. G-protein coupled receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Enzyme and pathway databases

    ReactomeiREACT_18289. P2Y receptors.
    REACT_19231. G alpha (i) signalling events.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    P2Y purinoceptor 14
    Short name:
    P2Y14
    Alternative name(s):
    G-protein coupled receptor 105
    UDP-glucose receptor
    Gene namesi
    Name:P2RY14
    Synonyms:GPR105, KIAA0001
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:16442. P2RY14.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA28853.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 338338P2Y purinoceptor 14PRO_0000070044Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi3 – 31N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
    Glycosylationi161 – 1611N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ15391.
    PRIDEiQ15391.

    PTM databases

    PhosphoSiteiQ15391.

    Expressioni

    Tissue specificityi

    Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.

    Gene expression databases

    ArrayExpressiQ15391.
    BgeeiQ15391.
    CleanExiHS_P2RY14.
    GenevestigatoriQ15391.

    Organism-specific databases

    HPAiCAB022646.

    Interactioni

    Protein-protein interaction databases

    STRINGi9606.ENSP00000308361.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2B6Vmodel-A1-338[»]
    ProteinModelPortaliQ15391.
    SMRiQ15391. Positions 14-309.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2929ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini51 – 555CytoplasmicSequence Analysis
    Topological domaini77 – 9620ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini118 – 13922CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini161 – 18828ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini210 – 23425CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini256 – 27823ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini300 – 33839CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei30 – 5021Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei56 – 7621Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei97 – 11721Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei140 – 16021Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei189 – 20921Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei235 – 25521Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei279 – 29921Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149084.
    HOGENOMiHOG000273884.
    HOVERGENiHBG108228.
    InParanoidiQ15391.
    KOiK04299.
    OMAiFLCQPFR.
    OrthoDBiEOG7JX34K.
    PhylomeDBiQ15391.
    TreeFamiTF330969.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005466. P2Y14_rcpt.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR00237. GPCRRHODOPSN.
    PR01655. UDPGLUCOSER.
    PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15391-1 [UniParc]FASTAAdd to Basket

    « Hide

    MINSTSTQPP DESCSQNLLI TQQIIPVLYC MVFIAGILLN GVSGWIFFYV    50
    PSSKSFIIYL KNIVIADFVM SLTFPFKILG DSGLGPWQLN VFVCRVSAVL 100
    FYVNMYVSIV FFGLISFDRY YKIVKPLWTS FIQSVSYSKL LSVIVWMLML 150
    LLAVPNIILT NQSVREVTQI KCIELKSELG RKWHKASNYI FVAIFWIVFL 200
    LLIVFYTAIT KKIFKSHLKS SRNSTSVKKK SSRNIFSIVF VFFVCFVPYH 250
    IARIPYTKSQ TEAHYSCQSK EILRYMKEFT LLLSAANVCL DPIIYFFLCQ 300
    PFREILCKKL HIPLKAQNDL DISRIKRGNT TLESTDTL 338
    Length:338
    Mass (Da):38,971
    Last modified:November 1, 1996 - v1
    Checksum:i8DBE7C782CB4753D
    GO

    Sequence cautioni

    The sequence BAA02791.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti54 – 541K → E in AAH34989. (PubMed:15489334)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti140 – 1401L → P in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035767

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF456925 Genomic DNA. Translation: AAL47764.1.
    D13626 mRNA. Translation: BAA02791.2. Different initiation.
    BC034989 mRNA. Translation: AAH34989.1.
    CCDSiCCDS3156.1.
    RefSeqiNP_001074924.1. NM_001081455.1.
    NP_055694.3. NM_014879.3.
    XP_005247978.1. XM_005247921.1.
    XP_005247979.1. XM_005247922.2.
    XP_005247980.1. XM_005247923.1.
    XP_006713895.1. XM_006713832.1.
    UniGeneiHs.2465.

    Genome annotation databases

    EnsembliENST00000309170; ENSP00000308361; ENSG00000174944.
    ENST00000424796; ENSP00000408733; ENSG00000174944.
    GeneIDi9934.
    KEGGihsa:9934.
    UCSCiuc003eyr.1. human.

    Polymorphism databases

    DMDMi3122322.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF456925 Genomic DNA. Translation: AAL47764.1 .
    D13626 mRNA. Translation: BAA02791.2 . Different initiation.
    BC034989 mRNA. Translation: AAH34989.1 .
    CCDSi CCDS3156.1.
    RefSeqi NP_001074924.1. NM_001081455.1.
    NP_055694.3. NM_014879.3.
    XP_005247978.1. XM_005247921.1.
    XP_005247979.1. XM_005247922.2.
    XP_005247980.1. XM_005247923.1.
    XP_006713895.1. XM_006713832.1.
    UniGenei Hs.2465.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2B6V model - A 1-338 [» ]
    ProteinModelPortali Q15391.
    SMRi Q15391. Positions 14-309.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000308361.

    Chemistry

    BindingDBi Q15391.
    ChEMBLi CHEMBL4518.
    GuidetoPHARMACOLOGYi 330.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q15391.

    Polymorphism databases

    DMDMi 3122322.

    Proteomic databases

    PaxDbi Q15391.
    PRIDEi Q15391.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000309170 ; ENSP00000308361 ; ENSG00000174944 .
    ENST00000424796 ; ENSP00000408733 ; ENSG00000174944 .
    GeneIDi 9934.
    KEGGi hsa:9934.
    UCSCi uc003eyr.1. human.

    Organism-specific databases

    CTDi 9934.
    GeneCardsi GC03M150929.
    HGNCi HGNC:16442. P2RY14.
    HPAi CAB022646.
    MIMi 610116. gene.
    neXtProti NX_Q15391.
    PharmGKBi PA28853.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149084.
    HOGENOMi HOG000273884.
    HOVERGENi HBG108228.
    InParanoidi Q15391.
    KOi K04299.
    OMAi FLCQPFR.
    OrthoDBi EOG7JX34K.
    PhylomeDBi Q15391.
    TreeFami TF330969.

    Enzyme and pathway databases

    Reactomei REACT_18289. P2Y receptors.
    REACT_19231. G alpha (i) signalling events.

    Miscellaneous databases

    GenomeRNAii 9934.
    NextBioi 37474.
    PROi Q15391.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15391.
    Bgeei Q15391.
    CleanExi HS_P2RY14.
    Genevestigatori Q15391.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR005466. P2Y14_rcpt.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR00237. GPCRRHODOPSN.
    PR01655. UDPGLUCOSER.
    PROSITEi PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Bone marrow.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Testis.
    4. Cited for: FUNCTION.
    5. Cited for: VARIANT [LARGE SCALE ANALYSIS] PRO-140.

    Entry informationi

    Entry nameiP2Y14_HUMAN
    AccessioniPrimary (citable) accession number: Q15391
    Secondary accession number(s): Q8IYT7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 130 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3