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Protein

P2Y purinoceptor 14

Gene

P2RY14

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Receptor for UDP-glucose and other UDP-sugar coupled to G-proteins. Not activated by ATP, ADP, UTP or ATP.1 Publication

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174944-MONOMER.
ReactomeiR-HSA-417957. P2Y receptors.
R-HSA-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
P2Y purinoceptor 14
Short name:
P2Y14
Alternative name(s):
G-protein coupled receptor 105
UDP-glucose receptor
Gene namesi
Name:P2RY14
Synonyms:GPR105, KIAA0001
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:16442. P2RY14.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 55CytoplasmicSequence analysis5
Transmembranei56 – 76Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini77 – 96ExtracellularSequence analysisAdd BLAST20
Transmembranei97 – 117Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini118 – 139CytoplasmicSequence analysisAdd BLAST22
Transmembranei140 – 160Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini161 – 188ExtracellularSequence analysisAdd BLAST28
Transmembranei189 – 209Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini210 – 234CytoplasmicSequence analysisAdd BLAST25
Transmembranei235 – 255Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini256 – 278ExtracellularSequence analysisAdd BLAST23
Transmembranei279 – 299Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini300 – 338CytoplasmicSequence analysisAdd BLAST39

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: GO_Central
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi9934.
OpenTargetsiENSG00000174944.
PharmGKBiPA28853.

Chemistry databases

ChEMBLiCHEMBL4518.
GuidetoPHARMACOLOGYi330.

Polymorphism and mutation databases

BioMutaiP2RY14.
DMDMi3122322.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000700441 – 338P2Y purinoceptor 14Add BLAST338

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi94 ↔ 172PROSITE-ProRule annotation
Glycosylationi161N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15391.
PeptideAtlasiQ15391.
PRIDEiQ15391.

PTM databases

iPTMnetiQ15391.
PhosphoSitePlusiQ15391.

Expressioni

Tissue specificityi

Highest expression in the placenta, adipose tissue, stomach and intestine, intermediate levels in the brain, spleen, lung and heart, lowest levels in the kidney.

Gene expression databases

BgeeiENSG00000174944.
CleanExiHS_P2RY14.
ExpressionAtlasiQ15391. baseline and differential.
GenevisibleiQ15391. HS.

Organism-specific databases

HPAiCAB022646.
HPA030398.

Interactioni

Protein-protein interaction databases

BioGridi115260. 3 interactors.
STRINGi9606.ENSP00000308361.

Chemistry databases

BindingDBiQ15391.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6Vmodel-A1-338[»]
ProteinModelPortaliQ15391.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IK1E. Eukaryota.
ENOG4111GWF. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ15391.
KOiK04299.
OMAiWHKASNY.
OrthoDBiEOG091G0F4B.
PhylomeDBiQ15391.
TreeFamiTF330969.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005466. P2Y14_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01655. UDPGLUCOSER.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15391-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MINSTSTQPP DESCSQNLLI TQQIIPVLYC MVFIAGILLN GVSGWIFFYV
60 70 80 90 100
PSSKSFIIYL KNIVIADFVM SLTFPFKILG DSGLGPWQLN VFVCRVSAVL
110 120 130 140 150
FYVNMYVSIV FFGLISFDRY YKIVKPLWTS FIQSVSYSKL LSVIVWMLML
160 170 180 190 200
LLAVPNIILT NQSVREVTQI KCIELKSELG RKWHKASNYI FVAIFWIVFL
210 220 230 240 250
LLIVFYTAIT KKIFKSHLKS SRNSTSVKKK SSRNIFSIVF VFFVCFVPYH
260 270 280 290 300
IARIPYTKSQ TEAHYSCQSK EILRYMKEFT LLLSAANVCL DPIIYFFLCQ
310 320 330
PFREILCKKL HIPLKAQNDL DISRIKRGNT TLESTDTL
Length:338
Mass (Da):38,971
Last modified:November 1, 1996 - v1
Checksum:i8DBE7C782CB4753D
GO

Sequence cautioni

The sequence BAA02791 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti54K → E in AAH34989 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035767140L → P in a colorectal cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF456925 Genomic DNA. Translation: AAL47764.1.
D13626 mRNA. Translation: BAA02791.2. Different initiation.
BC034989 mRNA. Translation: AAH34989.1.
CCDSiCCDS3156.1.
RefSeqiNP_001074924.1. NM_001081455.1.
NP_055694.3. NM_014879.3.
XP_005247979.1. XM_005247922.3.
XP_005247980.1. XM_005247923.3.
XP_011511642.1. XM_011513340.2.
XP_016863072.1. XM_017007583.1.
UniGeneiHs.2465.

Genome annotation databases

EnsembliENST00000309170; ENSP00000308361; ENSG00000174944.
ENST00000424796; ENSP00000408733; ENSG00000174944.
GeneIDi9934.
KEGGihsa:9934.
UCSCiuc003eyr.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF456925 Genomic DNA. Translation: AAL47764.1.
D13626 mRNA. Translation: BAA02791.2. Different initiation.
BC034989 mRNA. Translation: AAH34989.1.
CCDSiCCDS3156.1.
RefSeqiNP_001074924.1. NM_001081455.1.
NP_055694.3. NM_014879.3.
XP_005247979.1. XM_005247922.3.
XP_005247980.1. XM_005247923.3.
XP_011511642.1. XM_011513340.2.
XP_016863072.1. XM_017007583.1.
UniGeneiHs.2465.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2B6Vmodel-A1-338[»]
ProteinModelPortaliQ15391.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115260. 3 interactors.
STRINGi9606.ENSP00000308361.

Chemistry databases

BindingDBiQ15391.
ChEMBLiCHEMBL4518.
GuidetoPHARMACOLOGYi330.

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiQ15391.
PhosphoSitePlusiQ15391.

Polymorphism and mutation databases

BioMutaiP2RY14.
DMDMi3122322.

Proteomic databases

PaxDbiQ15391.
PeptideAtlasiQ15391.
PRIDEiQ15391.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000309170; ENSP00000308361; ENSG00000174944.
ENST00000424796; ENSP00000408733; ENSG00000174944.
GeneIDi9934.
KEGGihsa:9934.
UCSCiuc003eyr.2. human.

Organism-specific databases

CTDi9934.
DisGeNETi9934.
GeneCardsiP2RY14.
HGNCiHGNC:16442. P2RY14.
HPAiCAB022646.
HPA030398.
MIMi610116. gene.
neXtProtiNX_Q15391.
OpenTargetsiENSG00000174944.
PharmGKBiPA28853.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IK1E. Eukaryota.
ENOG4111GWF. LUCA.
GeneTreeiENSGT00640000091213.
HOGENOMiHOG000273884.
HOVERGENiHBG108228.
InParanoidiQ15391.
KOiK04299.
OMAiWHKASNY.
OrthoDBiEOG091G0F4B.
PhylomeDBiQ15391.
TreeFamiTF330969.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000174944-MONOMER.
ReactomeiR-HSA-417957. P2Y receptors.
R-HSA-418594. G alpha (i) signalling events.

Miscellaneous databases

GenomeRNAii9934.
PROiQ15391.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000174944.
CleanExiHS_P2RY14.
ExpressionAtlasiQ15391. baseline and differential.
GenevisibleiQ15391. HS.

Family and domain databases

InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR005466. P2Y14_rcpt.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR00237. GPCRRHODOPSN.
PR01655. UDPGLUCOSER.
PROSITEiPS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiP2Y14_HUMAN
AccessioniPrimary (citable) accession number: Q15391
Secondary accession number(s): Q8IYT7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: November 2, 2016
This is version 147 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.