Reviewed, UniProtKB/Swiss-Prot Q15389 (ANGP1_HUMAN)

Names and origin

Protein names

Recommended name:
    Angiopoietin-1
      Short name=ANG-1

Gene names

Name:	ANGPT1
Synonyms:	KIAA0003

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	498 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
Subcellular location	Secreted.
Post-translational modification	Glycosylated.
Miscellaneous	It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.
Sequence similarities	Contains 1 fibrinogen C-terminal domain.

Ontologies

Keywords
Biological process	Angiogenesis Differentiation
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Coiled coil Signal
Molecular function	Developmental protein
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	angiogenesis Inferred from electronic annotation. Source: UniProtKB-KW cell differentiation Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	receptor binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 498	483	Angiopoietin-1		PRO_0000009110
Regions
	Domain	277 – 497	221	Fibrinogen C-terminal
	Coiled coil	81 – 119	39	Potential
	Coiled coil	153 – 261	109	Potential
Amino acid modifications
	Glycosylation	92	1	N-linked (GlcNAc...) Potential
	Glycosylation	122	1	N-linked (GlcNAc...) Potential
	Glycosylation	154	1	N-linked (GlcNAc...) Potential
	Glycosylation	243	1	N-linked (GlcNAc...) Potential
	Glycosylation	295	1	N-linked (GlcNAc...) Potential
	Disulfide bond	286 ↔ 315		By similarity
	Disulfide bond	439 ↔ 452		By similarity
Natural variations
	Natural variant	269	1	Missing in cell line T98G; may be due to exon slippage.		VAR_009940

Sequences

	Sequence		Length	Mass (Da)
	Q15389-1 [UniParc]. Last modified January 1, 1998. Version 2. Checksum: 5D5FA63AEF6BE920	FASTA	498	57,513
	10 20 30 40 50 60 MTVFLSFAFL AAILTHIGCS NQRRSPENSG RRYNRIQHGQ CAYTFILPEH DGNCRESTTD 70 80 90 100 110 120 QYNTNALQRD APHVEPDFSS QKLQHLEHVM ENYTQWLQKL ENYIVENMKS EMAQIQQNAV 130 140 150 160 170 180 QNHTATMLEI GTSLLSQTAE QTRKLTDVET QVLNQTSRLE IQLLENSLST YKLEKQLLQQ 190 200 210 220 230 240 TNEILKIHEK NSLLEHKILE MEGKHKEELD TLKEEKENLQ GLVTRQTYII QELEKQLNRA 250 260 270 280 290 300 TTNNSVLQKQ QLELMDTVHN LVNLCTKEGV LLKGGKREEE KPFRDCADVY QAGFNKSGIY 310 320 330 340 350 360 TIYINNMPEP KKVFCNMDVN GGGWTVIQHR EDGSLDFQRG WKEYKMGFGN PSGEYWLGNE 370 380 390 400 410 420 FIFAITSQRQ YMLRIELMDW EGNRAYSQYD RFHIGNEKQN YRLYLKGHTG TAGKQSSLIL 430 440 450 460 470 480 HGADFSTKDA DNDNCMCKCA LMLTGGWWFD ACGPSNLNGM FYTAGQNHGK LNGIKWHYFK 490 GPSYSLRSTT MMIRPLDF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning." Davis S., Aldrich T.H., Jones P.F., Acheson A., Compton D.L., Jain V., Ryan T.E., Bruno J., Radziejewski C., Maisonpierre P.C., Yancopoulos G.D. Cell 87:1161-1169(1996) [PubMed: 8980223] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-269 DEL. Tissue: Fetal lung.
[2]	"Human angiopoietin-1 mRNA variant form." Nakatsukasa M., Komai K., Shiozawa S. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-269 DEL.
[3]	"Human angiopoietin-1 mRNA variant forms." Shan Z.X., Yu X.Y., Lin Q.Y., Fu Y.H., Tan H.H., Zheng M., Lin S.G. Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-269 DEL.
[4]	"Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1." Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S. DNA Res. 1:27-35(1994) [PubMed: 7584026] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Bone marrow.
[5]	"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones." Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T. DNA Res. 9:99-106(2002) [PubMed: 12168954] [Abstract] Cited for: SEQUENCE REVISION.
+	Additional computationally mapped references.

Web resources

Wikipedia

Angiopoietin entry

Cross-references

Sequence databases
EMBLGenBankDDBJ	U83508 mRNA. Translation: AAB50557.1. AB084454 mRNA. Translation: BAB91325.1. AY121504 mRNA. Translation: AAM81745.1. AY124380 mRNA. Translation: AAM92271.1. D13628 mRNA. Translation: BAA02793.2. Different initiation.
IPI	IPI00016677.
RefSeq	NP_001137.2.
UniGene	Hs.369675
3D structure databases
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-6046N.
STRING	Q15389.
PTM databases
PhosphoSite	Q15389.
Proteomic databases
PRIDE	Q15389.
Genome annotation databases
Ensembl	ENST00000297450; ENSP00000297450; ENSG00000154188; Homo sapiens. [Genome view]
GeneID	284.
KEGG	hsa:284.
UCSC	uc003ymn.1. human.
Organism-specific databases
CTD	284.
GeneCards	GC08M108330.
H-InvDB	HIX0007720.
HGNC	HGNC:484. ANGPT1.
HPA	CAB017815. HPA018793. HPA018816.
MIM	601667. gene.
PharmGKB	PA24791.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
HOGENOM	HBG444111.
HOVERGEN	Q15389.
InParanoid	Q15389.
OMA	VFCNMDL.
OrthoDB	EOG98WFN1.
Enzyme and pathway databases
Pathway_Interaction_DB	angiopoietinreceptor_pathway. Angiopoietin receptor Tie2-mediated signaling.
Reactome	REACT_604. Hemostasis. REACT_6900. Signaling in Immune system.
Gene expression databases
ArrayExpress	Q15389.
Bgee	Q15389.
CleanEx	HS_ANGPT1.
Genevestigator	Q15389.
GermOnline	ENSG00000154188. Homo sapiens.
Family and domain databases
InterPro	IPR002181. Fibrinogen_a/b/g_C. IPR014716. Fibrinogen_a/b/g_C_1. IPR020837. Fibrinogen_CS. [Graphical view]
Gene3D	G3DSA:3.90.215.10. Fibrinogen_a/b/g_C_1. 1 hit.
Pfam	PF00147. Fibrinogen_C. 1 hit. [Graphical view]
SMART	SM00186. FBG. 1 hit. [Graphical view]
PROSITE	PS00514. FIBRINOGEN_C_1. 1 hit. PS51406. FIBRINOGEN_C_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	1147.
SOURCE	Search...

Entry information

Entry name

ANGP1_HUMAN

Accession

Primary (citable) accession number: Q15389

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	January 1, 1998
Last modified:	December 15, 2009
This is version 86 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.