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Q15389

- ANGP1_HUMAN

UniProt

Q15389 - ANGP1_HUMAN

Protein

Angiopoietin-1

Gene

ANGPT1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 2 (01 Jan 1998)
      Previous versions | rss
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    Functioni

    Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.4 Publications

    GO - Molecular functioni

    1. receptor tyrosine kinase binding Source: UniProtKB

    GO - Biological processi

    1. activation of transmembrane receptor protein tyrosine kinase activity Source: UniProtKB
    2. blood coagulation Source: Reactome
    3. cell differentiation Source: UniProtKB-KW
    4. cell-substrate adhesion Source: Ensembl
    5. glomerulus vasculature development Source: UniProtKB
    6. hemopoiesis Source: Ensembl
    7. heparin biosynthetic process Source: UniProtKB
    8. in utero embryonic development Source: Ensembl
    9. leukocyte migration Source: Reactome
    10. negative regulation of apoptotic process Source: UniProtKB
    11. negative regulation of cell adhesion Source: UniProtKB
    12. negative regulation of endothelial cell apoptotic process Source: UniProtKB
    13. negative regulation of neuron apoptotic process Source: Ensembl
    14. negative regulation of vascular permeability Source: UniProtKB
    15. positive chemotaxis Source: UniProtKB
    16. positive regulation of blood vessel endothelial cell migration Source: UniProtKB
    17. positive regulation of cell adhesion Source: Ensembl
    18. positive regulation of endothelial cell migration Source: UniProtKB
    19. positive regulation of ERK1 and ERK2 cascade Source: UniProtKB
    20. positive regulation of peptidyl-serine phosphorylation Source: Ensembl
    21. positive regulation of peptidyl-tyrosine phosphorylation Source: UniProtKB
    22. positive regulation of phosphatidylinositol 3-kinase signaling Source: Ensembl
    23. positive regulation of protein kinase B signaling Source: UniProtKB
    24. positive regulation of protein ubiquitination Source: UniProtKB
    25. positive regulation of receptor internalization Source: UniProtKB
    26. protein localization to cell surface Source: UniProtKB
    27. regulation of satellite cell proliferation Source: UniProtKB
    28. sprouting angiogenesis Source: UniProtKB
    29. Tie signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Angiogenesis, Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_12621. Tie2 Signaling.
    SignaLinkiQ15389.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Angiopoietin-1
    Short name:
    ANG-1
    Gene namesi
    Name:ANGPT1
    Synonyms:KIAA0003
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 8

    Organism-specific databases

    HGNCiHGNC:484. ANGPT1.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: Reactome
    2. extracellular space Source: UniProtKB
    3. extracellular vesicular exosome Source: UniProt
    4. membrane raft Source: UniProtKB
    5. microvillus Source: UniProtKB
    6. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24791.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 498483Angiopoietin-1PRO_0000009110Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi92 – 921N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi122 – 1221N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi154 – 1541N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi243 – 2431N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi286 ↔ 315PROSITE-ProRule annotation
    Glycosylationi295 – 2951N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi439 ↔ 452PROSITE-ProRule annotation

    Post-translational modificationi

    Glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ15389.
    PRIDEiQ15389.

    PTM databases

    PhosphoSiteiQ15389.

    Expressioni

    Gene expression databases

    ArrayExpressiQ15389.
    BgeeiQ15389.
    CleanExiHS_ANGPT1.
    GenevestigatoriQ15389.

    Organism-specific databases

    HPAiCAB017815.
    HPA018793.
    HPA018816.

    Interactioni

    Subunit structurei

    Homooligomer. Interacts with TEK/TIE2.3 Publications

    Protein-protein interaction databases

    BioGridi106781. 2 interactions.
    DIPiDIP-6046N.
    IntActiQ15389. 1 interaction.
    STRINGi9606.ENSP00000297450.

    Structurei

    Secondary structure

    1
    498
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi286 – 2916
    Beta strandi298 – 3025
    Beta strandi311 – 3166
    Helixi319 – 3213
    Beta strandi324 – 33310
    Helixi341 – 3466
    Beta strandi353 – 3564
    Helixi359 – 3668
    Beta strandi371 – 3788
    Beta strandi384 – 39411
    Helixi397 – 3993
    Beta strandi403 – 41210
    Beta strandi433 – 4375
    Helixi439 – 4435
    Beta strandi450 – 4523
    Beta strandi454 – 4563
    Turni463 – 4675
    Beta strandi473 – 4764
    Turni477 – 4793
    Beta strandi487 – 4959

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4EPUX-ray2.10A/B282-497[»]
    4JYOX-ray2.50X280-498[»]
    4K0VX-ray4.51B280-498[»]
    ProteinModelPortaliQ15389.
    SMRiQ15389. Positions 172-497.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini277 – 497221Fibrinogen C-terminalPROSITE-ProRule annotationAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili81 – 11939Sequence AnalysisAdd
    BLAST
    Coiled coili153 – 261109Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Signal

    Phylogenomic databases

    eggNOGiNOG310490.
    HOGENOMiHOG000037128.
    HOVERGENiHBG001644.
    InParanoidiQ15389.
    KOiK05465.
    OMAiTSQRQYS.
    OrthoDBiEOG7X9G60.
    PhylomeDBiQ15389.
    TreeFamiTF336658.

    Family and domain databases

    Gene3Di3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProiIPR028843. Ang-1.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view]
    PANTHERiPTHR19143:SF156. PTHR19143:SF156. 1 hit.
    PfamiPF00147. Fibrinogen_C. 1 hit.
    [Graphical view]
    SMARTiSM00186. FBG. 1 hit.
    [Graphical view]
    SUPFAMiSSF56496. SSF56496. 1 hit.
    PROSITEiPS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15389-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTVFLSFAFL AAILTHIGCS NQRRSPENSG RRYNRIQHGQ CAYTFILPEH    50
    DGNCRESTTD QYNTNALQRD APHVEPDFSS QKLQHLEHVM ENYTQWLQKL 100
    ENYIVENMKS EMAQIQQNAV QNHTATMLEI GTSLLSQTAE QTRKLTDVET 150
    QVLNQTSRLE IQLLENSLST YKLEKQLLQQ TNEILKIHEK NSLLEHKILE 200
    MEGKHKEELD TLKEEKENLQ GLVTRQTYII QELEKQLNRA TTNNSVLQKQ 250
    QLELMDTVHN LVNLCTKEGV LLKGGKREEE KPFRDCADVY QAGFNKSGIY 300
    TIYINNMPEP KKVFCNMDVN GGGWTVIQHR EDGSLDFQRG WKEYKMGFGN 350
    PSGEYWLGNE FIFAITSQRQ YMLRIELMDW EGNRAYSQYD RFHIGNEKQN 400
    YRLYLKGHTG TAGKQSSLIL HGADFSTKDA DNDNCMCKCA LMLTGGWWFD 450
    ACGPSNLNGM FYTAGQNHGK LNGIKWHYFK GPSYSLRSTT MMIRPLDF 498
    Length:498
    Mass (Da):57,513
    Last modified:January 1, 1998 - v2
    Checksum:i5D5FA63AEF6BE920
    GO
    Isoform 2 (identifier: Q15389-2) [UniParc]FASTAAdd to Basket

    Also known as: Gly-269 del

    The sequence of this isoform differs from the canonical sequence as follows:
         269-269: Missing.

    Show »
    Length:497
    Mass (Da):57,456
    Checksum:i3055148F097AC6AF
    GO

    Sequence cautioni

    The sequence BAA02793.2 differs from that shown. Reason: Erroneous initiation.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti247 – 2471L → P.
    Corresponds to variant rs73701083 [ dbSNP | Ensembl ].
    VAR_069165

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei269 – 2691Missing in isoform 2. 3 PublicationsVSP_046324

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83508 mRNA. Translation: AAB50557.1.
    AB084454 mRNA. Translation: BAB91325.1.
    AY121504 mRNA. Translation: AAM81745.1.
    AY124380 mRNA. Translation: AAM92271.1.
    D13628 mRNA. Translation: BAA02793.2. Different initiation.
    BX648814 mRNA. Translation: CAI45984.1.
    AC091010 Genomic DNA. No translation available.
    AP000428 Genomic DNA. No translation available.
    AP003480 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW91909.1.
    BC152411 mRNA. Translation: AAI52412.1.
    BC152419 mRNA. Translation: AAI52420.1.
    CCDSiCCDS56551.1. [Q15389-2]
    CCDS6306.1. [Q15389-1]
    RefSeqiNP_001137.2. NM_001146.3. [Q15389-1]
    NP_001186788.1. NM_001199859.1. [Q15389-2]
    UniGeneiHs.369675.

    Genome annotation databases

    EnsembliENST00000297450; ENSP00000297450; ENSG00000154188. [Q15389-2]
    ENST00000517746; ENSP00000428340; ENSG00000154188. [Q15389-1]
    GeneIDi284.
    KEGGihsa:284.
    UCSCiuc003ymn.3. human. [Q15389-1]

    Polymorphism databases

    DMDMi12229574.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    Angiopoietin entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U83508 mRNA. Translation: AAB50557.1 .
    AB084454 mRNA. Translation: BAB91325.1 .
    AY121504 mRNA. Translation: AAM81745.1 .
    AY124380 mRNA. Translation: AAM92271.1 .
    D13628 mRNA. Translation: BAA02793.2 . Different initiation.
    BX648814 mRNA. Translation: CAI45984.1 .
    AC091010 Genomic DNA. No translation available.
    AP000428 Genomic DNA. No translation available.
    AP003480 Genomic DNA. No translation available.
    CH471060 Genomic DNA. Translation: EAW91909.1 .
    BC152411 mRNA. Translation: AAI52412.1 .
    BC152419 mRNA. Translation: AAI52420.1 .
    CCDSi CCDS56551.1. [Q15389-2 ]
    CCDS6306.1. [Q15389-1 ]
    RefSeqi NP_001137.2. NM_001146.3. [Q15389-1 ]
    NP_001186788.1. NM_001199859.1. [Q15389-2 ]
    UniGenei Hs.369675.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4EPU X-ray 2.10 A/B 282-497 [» ]
    4JYO X-ray 2.50 X 280-498 [» ]
    4K0V X-ray 4.51 B 280-498 [» ]
    ProteinModelPortali Q15389.
    SMRi Q15389. Positions 172-497.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106781. 2 interactions.
    DIPi DIP-6046N.
    IntActi Q15389. 1 interaction.
    STRINGi 9606.ENSP00000297450.

    PTM databases

    PhosphoSitei Q15389.

    Polymorphism databases

    DMDMi 12229574.

    Proteomic databases

    PaxDbi Q15389.
    PRIDEi Q15389.

    Protocols and materials databases

    DNASUi 284.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000297450 ; ENSP00000297450 ; ENSG00000154188 . [Q15389-2 ]
    ENST00000517746 ; ENSP00000428340 ; ENSG00000154188 . [Q15389-1 ]
    GeneIDi 284.
    KEGGi hsa:284.
    UCSCi uc003ymn.3. human. [Q15389-1 ]

    Organism-specific databases

    CTDi 284.
    GeneCardsi GC08M108330.
    HGNCi HGNC:484. ANGPT1.
    HPAi CAB017815.
    HPA018793.
    HPA018816.
    MIMi 601667. gene.
    neXtProti NX_Q15389.
    PharmGKBi PA24791.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG310490.
    HOGENOMi HOG000037128.
    HOVERGENi HBG001644.
    InParanoidi Q15389.
    KOi K05465.
    OMAi TSQRQYS.
    OrthoDBi EOG7X9G60.
    PhylomeDBi Q15389.
    TreeFami TF336658.

    Enzyme and pathway databases

    Reactomei REACT_12621. Tie2 Signaling.
    SignaLinki Q15389.

    Miscellaneous databases

    ChiTaRSi ANGPT1. human.
    GeneWikii Angiopoietin_1.
    GenomeRNAii 284.
    NextBioi 1147.
    PROi Q15389.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15389.
    Bgeei Q15389.
    CleanExi HS_ANGPT1.
    Genevestigatori Q15389.

    Family and domain databases

    Gene3Di 3.90.215.10. 1 hit.
    4.10.530.10. 1 hit.
    InterProi IPR028843. Ang-1.
    IPR014716. Fibrinogen_a/b/g_C_1.
    IPR014715. Fibrinogen_a/b/g_C_2.
    IPR002181. Fibrinogen_a/b/g_C_dom.
    IPR020837. Fibrinogen_CS.
    [Graphical view ]
    PANTHERi PTHR19143:SF156. PTHR19143:SF156. 1 hit.
    Pfami PF00147. Fibrinogen_C. 1 hit.
    [Graphical view ]
    SMARTi SM00186. FBG. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56496. SSF56496. 1 hit.
    PROSITEi PS00514. FIBRINOGEN_C_1. 1 hit.
    PS51406. FIBRINOGEN_C_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning."
      Davis S., Aldrich T.H., Jones P.F., Acheson A., Compton D.L., Jain V., Ryan T.E., Bruno J., Radziejewski C., Maisonpierre P.C., Yancopoulos G.D.
      Cell 87:1161-1169(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Fetal lung.
    2. "Human angiopoietin-1 mRNA variant form."
      Nakatsukasa M., Komai K., Shiozawa S.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    3. "Human angiopoietin-1 mRNA variant forms."
      Shan Z.X., Yu X.Y., Lin Q.Y., Fu Y.H., Tan H.H., Zheng M., Lin S.G.
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    4. "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N., Miyajima N., Sazuka T., Tanaka A., Kawarabayasi Y., Sato S., Nagase T., Seki N., Ishikawa K., Tabata S.
      DNA Res. 1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Bone marrow.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Small intestine.
    6. "DNA sequence and analysis of human chromosome 8."
      Nusbaum C., Mikkelsen T.S., Zody M.C., Asakawa S., Taudien S., Garber M., Kodira C.D., Schueler M.G., Shimizu A., Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X., Allen N.R., Anderson S., Asakawa T.
      , Blechschmidt K., Bloom T., Borowsky M.L., Butler J., Cook A., Corum B., DeArellano K., DeCaprio D., Dooley K.T., Dorris L. III, Engels R., Gloeckner G., Hafez N., Hagopian D.S., Hall J.L., Ishikawa S.K., Jaffe D.B., Kamat A., Kudoh J., Lehmann R., Lokitsang T., Macdonald P., Major J.E., Matthews C.D., Mauceli E., Menzel U., Mihalev A.H., Minoshima S., Murayama Y., Naylor J.W., Nicol R., Nguyen C., O'Leary S.B., O'Neill K., Parker S.C.J., Polley A., Raymond C.K., Reichwald K., Rodriguez J., Sasaki T., Schilhabel M., Siddiqui R., Smith C.L., Sneddon T.P., Talamas J.A., Tenzin P., Topham K., Venkataraman V., Wen G., Yamazaki S., Young S.K., Zeng Q., Zimmer A.R., Rosenthal A., Birren B.W., Platzer M., Shimizu N., Lander E.S.
      Nature 439:331-335(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    8. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    9. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
      Nakajima D., Okazaki N., Yamakawa H., Kikuno R., Ohara O., Nagase T.
      DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: SEQUENCE REVISION.
    10. Cited for: FUNCTION, INTERACTION WITH TEK.
    11. "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats."
      Fiedler U., Krissl T., Koidl S., Weiss C., Koblizek T., Deutsch U., Martiny-Baron G., Marme D., Augustin H.G.
      J. Biol. Chem. 278:1721-1727(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TEK.
    12. "Biological characterization of angiopoietin-3 and angiopoietin-4."
      Lee H.J., Cho C.H., Hwang S.J., Choi H.H., Kim K.T., Ahn S.Y., Kim J.H., Oh J.L., Lee G.M., Koh G.Y.
      FASEB J. 18:1200-1208(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1, INTERACTION WITH TEK/TIE2.
    13. "Differential function of Tie2 at cell-cell contacts and cell-substratum contacts regulated by angiopoietin-1."
      Fukuhara S., Sako K., Minami T., Noda K., Kim H.Z., Kodama T., Shibuya M., Takakura N., Koh G.Y., Mochizuki N.
      Nat. Cell Biol. 10:513-526(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF ENDOTHELIAL CELL MIGRATION AND CELL SPREADING.
    14. "Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts."
      Saharinen P., Eklund L., Miettinen J., Wirkkala R., Anisimov A., Winderlich M., Nottebaum A., Vestweber D., Deutsch U., Koh G.Y., Olsen B.R., Alitalo K.
      Nat. Cell Biol. 10:527-537(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN REGULATION OF ENDOTHELIAL CELL MIGRATION.
    15. "Control of vascular morphogenesis and homeostasis through the angiopoietin-Tie system."
      Augustin H.G., Koh G.Y., Thurston G., Alitalo K.
      Nat. Rev. Mol. Cell Biol. 10:165-177(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    16. "Angiopoietin-1/Tie2 receptor signaling in vascular quiescence and angiogenesis."
      Fukuhara S., Sako K., Noda K., Zhang J., Minami M., Mochizuki N.
      Histol. Histopathol. 25:387-396(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.
    17. "Targeting the ANGPT-TIE2 pathway in malignancy."
      Huang H., Bhat A., Woodnutt G., Lappe R.
      Nat. Rev. Cancer 10:575-585(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW.

    Entry informationi

    Entry nameiANGP1_HUMAN
    AccessioniPrimary (citable) accession number: Q15389
    Secondary accession number(s): Q5HYA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: January 1, 1998
    Last modified: October 1, 2014
    This is version 133 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    It may have a potential therapeutic utility since it can be used for specifically targeting tumor vasculature or for promoting angiogenic processes in certain organs such as an ischemic heart.

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 8
      Human chromosome 8: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3