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Protein

Mitochondrial import receptor subunit TOM20 homolog

Gene

TOMM20

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Central component of the receptor complex responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with TOM22 functions as the transit peptide receptor at the surface of the mitochondrion outer membrane and facilitates the movement of preproteins into the TOM40 translocation pore (By similarity).By similarity

GO - Molecular functioni

  • mitochondrion targeting sequence binding Source: GO_Central
  • P-P-bond-hydrolysis-driven protein transmembrane transporter activity Source: HGNC
  • unfolded protein binding Source: HGNC

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173726-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.
R-HSA-5689880. Ub-specific processing proteases.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import receptor subunit TOM20 homolog
Alternative name(s):
Mitochondrial 20 kDa outer membrane protein
Outer mitochondrial membrane receptor Tom20
Gene namesi
Name:TOMM20
Synonyms:KIAA0016
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:20947. TOMM20.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 6Mitochondrial intermembraneSequence analysis6
Transmembranei7 – 24HelicalSequence analysisAdd BLAST18
Topological domaini25 – 145CytoplasmicSequence analysisAdd BLAST121

GO - Cellular componenti

  • ER-mitochondrion membrane contact site Source: MGI
  • extracellular matrix Source: BHF-UCL
  • integral component of mitochondrial outer membrane Source: GO_Central
  • mitochondrial outer membrane Source: UniProtKB
  • mitochondrial outer membrane translocase complex Source: UniProtKB
  • mitochondrion Source: HPA
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion outer membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi56K → R: Defects in mitophagy; when associated with R-61 and R-68. 1 Publication1
Mutagenesisi61K → R: Defects in mitophagy; when associated with R-56 and R-68. 1 Publication1
Mutagenesisi68K → R: Defects in mitophagy; when associated with R-56 and R-61. 1 Publication1

Organism-specific databases

OpenTargetsiENSG00000173726.
PharmGKBiPA134964372.

Polymorphism and mutation databases

BioMutaiTOMM20.
DMDMi2498697.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000515381 – 145Mitochondrial import receptor subunit TOM20 homologAdd BLAST145

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Cross-linki56Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki61Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)2 Publications
Cross-linki68Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)1 Publication
Modified residuei135PhosphoserineCombined sources1
Modified residuei138PhosphoserineCombined sources1

Post-translational modificationi

Ubiquitinated by PARK2 during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.2 Publications

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ15388.
MaxQBiQ15388.
PaxDbiQ15388.
PeptideAtlasiQ15388.
PRIDEiQ15388.
TopDownProteomicsiQ15388.

PTM databases

iPTMnetiQ15388.
PhosphoSitePlusiQ15388.

Expressioni

Gene expression databases

BgeeiENSG00000173726.
CleanExiHS_TOMM20.
ExpressionAtlasiQ15388. baseline and differential.
GenevisibleiQ15388. HS.

Organism-specific databases

HPAiCAB005585.
HPA011562.

Interactioni

Subunit structurei

Forms part of the preprotein translocase complex of the outer mitochondrial membrane (TOM complex) which consists of at least 7 different proteins (TOMM5, TOMM6, TOMM7, TOMM20, TOMM22, TOMM40 and TOMM70). Interacts with TOM22. Interacts with APEX1.2 Publications

GO - Molecular functioni

  • unfolded protein binding Source: HGNC

Protein-protein interaction databases

BioGridi115144. 45 interactors.
DIPiDIP-46735N.
IntActiQ15388. 28 interactors.
MINTiMINT-1403841.
STRINGi9606.ENSP00000355566.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4APOX-ray1.90D/E140-145[»]
ProteinModelPortaliQ15388.
SMRiQ15388.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Tom20 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4056. Eukaryota.
ENOG4111NAH. LUCA.
GeneTreeiENSGT00390000011698.
HOGENOMiHOG000006671.
HOVERGENiHBG057315.
InParanoidiQ15388.
KOiK17770.
OMAiAMLIIKM.
OrthoDBiEOG091G0Z80.
PhylomeDBiQ15388.
TreeFamiTF106200.

Family and domain databases

Gene3Di1.20.960.10. 1 hit.
InterProiIPR002056. MAS20.
IPR022422. MAS20_rcpt_metazoan.
IPR023392. Tom20_dom.
[Graphical view]
PANTHERiPTHR12430. PTHR12430. 1 hit.
PfamiPF02064. MAS20. 1 hit.
[Graphical view]
PIRSFiPIRSF037707. MAS20_rcpt. 1 hit.
PRINTSiPR01989. EUOM20RECPTR.
PR00351. OM20RECEPTOR.
SUPFAMiSSF47157. SSF47157. 1 hit.
TIGRFAMsiTIGR00985. 3a0801s04tom. 1 hit.

Sequencei

Sequence statusi: Complete.

Q15388-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVGRNSAIAA GVCGALFIGY CIYFDRKRRS DPNFKNRLRE RRKKQKLAKE
60 70 80 90 100
RAGLSKLPDL KDAEAVQKFF LEEIQLGEEL LAQGEYEKGV DHLTNAIAVC
110 120 130 140
GQPQQLLQVL QQTLPPPVFQ MLLTKLPTIS QRIVSAQSLA EDDVE
Length:145
Mass (Da):16,298
Last modified:November 1, 1996 - v1
Checksum:i5153BD25AC5D9B3A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti145E → D in CAG32999 (Ref. 6) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052366117P → L.Corresponds to variant rs16991984dbSNPEnsembl.1
Natural variantiVAR_052367134V → L.Corresponds to variant rs1049510dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126962
, AF126958, AF126959, AF126960, AF126961 Genomic DNA. Translation: AAF13354.1.
D13641 mRNA. Translation: BAA02804.1.
AK289810 mRNA. Translation: BAF82499.1.
CR456718 mRNA. Translation: CAG32999.1.
AL732292 Genomic DNA. Translation: CAI21937.1.
CH471098 Genomic DNA. Translation: EAW70003.1.
BC000882 mRNA. Translation: AAH00882.1.
BC066335 mRNA. Translation: AAH66335.1.
BC071994 mRNA. Translation: AAH71994.1.
BC100286 mRNA. Translation: AAI00287.1.
BC107851 mRNA. Translation: AAI07852.1.
CCDSiCCDS1603.1.
PIRiS68215.
RefSeqiNP_055580.1. NM_014765.2.
UniGeneiHs.533192.

Genome annotation databases

EnsembliENST00000366607; ENSP00000355566; ENSG00000173726.
GeneIDi9804.
KEGGihsa:9804.
UCSCiuc001hwl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF126962
, AF126958, AF126959, AF126960, AF126961 Genomic DNA. Translation: AAF13354.1.
D13641 mRNA. Translation: BAA02804.1.
AK289810 mRNA. Translation: BAF82499.1.
CR456718 mRNA. Translation: CAG32999.1.
AL732292 Genomic DNA. Translation: CAI21937.1.
CH471098 Genomic DNA. Translation: EAW70003.1.
BC000882 mRNA. Translation: AAH00882.1.
BC066335 mRNA. Translation: AAH66335.1.
BC071994 mRNA. Translation: AAH71994.1.
BC100286 mRNA. Translation: AAI00287.1.
BC107851 mRNA. Translation: AAI07852.1.
CCDSiCCDS1603.1.
PIRiS68215.
RefSeqiNP_055580.1. NM_014765.2.
UniGeneiHs.533192.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4APOX-ray1.90D/E140-145[»]
ProteinModelPortaliQ15388.
SMRiQ15388.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115144. 45 interactors.
DIPiDIP-46735N.
IntActiQ15388. 28 interactors.
MINTiMINT-1403841.
STRINGi9606.ENSP00000355566.

PTM databases

iPTMnetiQ15388.
PhosphoSitePlusiQ15388.

Polymorphism and mutation databases

BioMutaiTOMM20.
DMDMi2498697.

Proteomic databases

EPDiQ15388.
MaxQBiQ15388.
PaxDbiQ15388.
PeptideAtlasiQ15388.
PRIDEiQ15388.
TopDownProteomicsiQ15388.

Protocols and materials databases

DNASUi9804.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000366607; ENSP00000355566; ENSG00000173726.
GeneIDi9804.
KEGGihsa:9804.
UCSCiuc001hwl.4. human.

Organism-specific databases

CTDi9804.
GeneCardsiTOMM20.
HGNCiHGNC:20947. TOMM20.
HPAiCAB005585.
HPA011562.
MIMi601848. gene.
neXtProtiNX_Q15388.
OpenTargetsiENSG00000173726.
PharmGKBiPA134964372.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4056. Eukaryota.
ENOG4111NAH. LUCA.
GeneTreeiENSGT00390000011698.
HOGENOMiHOG000006671.
HOVERGENiHBG057315.
InParanoidiQ15388.
KOiK17770.
OMAiAMLIIKM.
OrthoDBiEOG091G0Z80.
PhylomeDBiQ15388.
TreeFamiTF106200.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000173726-MONOMER.
ReactomeiR-HSA-1268020. Mitochondrial protein import.
R-HSA-5205685. Pink/Parkin Mediated Mitophagy.
R-HSA-5689880. Ub-specific processing proteases.

Miscellaneous databases

ChiTaRSiTOMM20. human.
GeneWikiiTOMM20.
GenomeRNAii9804.
PROiQ15388.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000173726.
CleanExiHS_TOMM20.
ExpressionAtlasiQ15388. baseline and differential.
GenevisibleiQ15388. HS.

Family and domain databases

Gene3Di1.20.960.10. 1 hit.
InterProiIPR002056. MAS20.
IPR022422. MAS20_rcpt_metazoan.
IPR023392. Tom20_dom.
[Graphical view]
PANTHERiPTHR12430. PTHR12430. 1 hit.
PfamiPF02064. MAS20. 1 hit.
[Graphical view]
PIRSFiPIRSF037707. MAS20_rcpt. 1 hit.
PRINTSiPR01989. EUOM20RECPTR.
PR00351. OM20RECEPTOR.
SUPFAMiSSF47157. SSF47157. 1 hit.
TIGRFAMsiTIGR00985. 3a0801s04tom. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiTOM20_HUMAN
AccessioniPrimary (citable) accession number: Q15388
Secondary accession number(s): A8K195, Q498B3, Q6IBT4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 162 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.