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Protein

Elongin-C

Gene

ELOC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).By similarity1 Publication
The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.4 Publications

GO - Biological processi

Keywordsi

Biological processHost-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORiQ15369

Names & Taxonomyi

Protein namesi
Recommended name:
Elongin-C
Short name:
EloC
Alternative name(s):
Elongin 15 kDa subunit
RNA polymerase II transcription factor SIII subunit C
SIII p15
Transcription elongation factor B polypeptide 1
Gene namesi
Name:ELOCImported
Synonyms:TCEB1Imported
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000154582.16
HGNCiHGNC:11617 ELOC
MIMi600788 gene
neXtProtiNX_Q15369

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6921
OpenTargetsiENSG00000154582
PharmGKBiPA36376

Chemistry databases

ChEMBLiCHEMBL3301400

Polymorphism and mutation databases

BioMutaiTCEB1
DMDMi32699511

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001872581 – 112Elongin-CAdd BLAST112

Proteomic databases

EPDiQ15369
MaxQBiQ15369
PaxDbiQ15369
PeptideAtlasiQ15369
PRIDEiQ15369
ProteomicsDBi60547
TopDownProteomicsiQ15369-1 [Q15369-1]

PTM databases

iPTMnetiQ15369
PhosphoSitePlusiQ15369
SwissPalmiQ15369

Expressioni

Tissue specificityi

Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.1 Publication

Gene expression databases

BgeeiENSG00000154582
CleanExiHS_TCEB1
ExpressionAtlasiQ15369 baseline and differential
GenevisibleiQ15369 HS

Organism-specific databases

HPAiHPA078113

Interactioni

Subunit structurei

Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit (PubMed:17997974). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (By similarity). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, ELOA, VHL or WSB1 (PubMed:15590694). The elongin BC complex is part of a complex with hydroxylated HIF1A (PubMed:12050673, PubMed:12004076). Interacts with VHL (PubMed:10205047, PubMed:12050673). Interacts with TMF1 (PubMed:15467733). Interacts with SPSB1 (PubMed:17189197). posed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2 (PubMed:11006129, PubMed:10205047, PubMed:12050673). Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component (PubMed:23102700).By similarity9 Publications
(Microbial infection) Substrate adapter protein can be a viral protein such as HIV Vif.1 Publication
(Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein NS1.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi112783, 153 interactors
CORUMiQ15369
DIPiDIP-29571N
IntActiQ15369, 61 interactors
MINTiQ15369
STRINGi9606.ENSP00000284811

Chemistry databases

BindingDBiQ15369

Structurei

Secondary structure

1112
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi18 – 22Combined sources5
Beta strandi24 – 26Combined sources3
Beta strandi28 – 32Combined sources5
Helixi33 – 36Combined sources4
Helixi40 – 46Combined sources7
Beta strandi47 – 50Combined sources4
Turni51 – 54Combined sources4
Beta strandi59 – 61Combined sources3
Beta strandi63 – 65Combined sources3
Helixi67 – 83Combined sources17
Turni84 – 86Combined sources3
Helixi97 – 99Combined sources3
Helixi100 – 110Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1LM8X-ray1.85C17-112[»]
1LQBX-ray2.00B17-112[»]
1VCBX-ray2.70B/E/H/K1-112[»]
2C9WX-ray1.90C17-112[»]
2IZVX-ray2.55C17-112[»]
2MA9NMR-C19-109[»]
3DCGX-ray2.40B/D17-112[»]
3ZKJX-ray2.58B/E17-112[»]
3ZNGX-ray2.85B/E17-112[»]
3ZRCX-ray2.90B/E/H/K17-112[»]
3ZRFX-ray2.80B/E/H/K17-112[»]
3ZTCX-ray2.65B/E/H/K17-112[»]
3ZTDX-ray2.79B/E/H/K17-112[»]
3ZUNX-ray2.50B/E/H/K17-112[»]
4AJYX-ray1.73C17-112[»]
4AWJX-ray2.50B/E/H/K17-112[»]
4B95X-ray2.80B/E/H/K18-112[»]
4B9KX-ray2.00B/E/H/K17-112[»]
4BKSX-ray2.20B/E/H/K17-112[»]
4BKTX-ray2.35B/E/H/K17-112[»]
4N9FX-ray3.305/B/E/K/Q/T/Y/Z/h/n/t/z17-112[»]
4W9CX-ray2.20B/E/H/K17-112[»]
4W9DX-ray2.20B/E/H/K17-112[»]
4W9EX-ray2.60B/E/H/K17-112[»]
4W9FX-ray2.10B/E/H/K17-112[»]
4W9GX-ray2.70B/E/H/K17-112[»]
4W9HX-ray2.10B/E/H/K17-112[»]
4W9IX-ray2.40B/E/H/K17-112[»]
4W9JX-ray2.20B/E/H/K17-112[»]
4W9KX-ray2.10B/E/H/K17-112[»]
4W9LX-ray2.20B/E/H/K17-112[»]
4WQOX-ray3.20C17-112[»]
5BO4X-ray2.90C/F/I/L/O/R17-112[»]
5LLIX-ray2.40B/E/H/K17-112[»]
5N4WX-ray3.90C17-112[»]
5NVVX-ray2.10B/E/H/K17-112[»]
5NVWX-ray2.20B/E/H/K17-112[»]
5NVXX-ray2.20B/E/H/K17-112[»]
5NVYX-ray2.90B/E/H/K17-112[»]
5NVZX-ray2.70B/E/H/K17-112[»]
5NW0X-ray2.30B/E/H/K17-112[»]
5NW1X-ray2.10B/E/H/K17-112[»]
5NW2X-ray2.20B/E/H/K17-112[»]
5T35X-ray2.70C/G17-112[»]
6C5XX-ray3.10C/F17-112[»]
6FMIX-ray2.80B/E17-112[»]
6FMJX-ray2.45B/E/H/K17-112[»]
6FMKX-ray2.75B/E/H/K17-112[»]
ProteinModelPortaliQ15369
SMRiQ15369
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15369

Family & Domainsi

Sequence similaritiesi

Belongs to the SKP1 family.Curated

Phylogenomic databases

eggNOGiKOG3473 Eukaryota
ENOG41123WR LUCA
GeneTreeiENSGT00390000011717
HOGENOMiHOG000216525
HOVERGENiHBG007440
InParanoidiQ15369
KOiK03872
OMAiDMDIPVE
OrthoDBiEOG091G0W26
PhylomeDBiQ15369
TreeFamiTF300233

Family and domain databases

InterProiView protein in InterPro
IPR001232 SKP1-like
IPR011333 SKP1/BTB/POZ_sf
IPR016073 Skp1_comp_POZ
PfamiView protein in Pfam
PF03931 Skp1_POZ, 1 hit
SMARTiView protein in SMART
SM00512 Skp1, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15369-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG
60 70 80 90 100
QFAENETNEV NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA
110
LELLMAANFL DC
Length:112
Mass (Da):12,473
Last modified:November 1, 1996 - v1
Checksum:i98D88696E883538B
GO
Isoform 2 (identifier: Q15369-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: Missing.

Note: No experimental confirmation available.
Show »
Length:96
Mass (Da):10,832
Checksum:i749EC1F8EC3DB62E
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0459551 – 16Missing in isoform 2. 1 PublicationAdd BLAST16

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L34587 mRNA Translation: AAA67650.1
BX649138 mRNA No translation available.
AC022868 Genomic DNA No translation available.
BC013809 mRNA Translation: AAH13809.1
BC093065 mRNA Translation: AAH93065.1
BC100028 mRNA Translation: AAI00029.1
BC100283 mRNA Translation: AAI00284.1
CCDSiCCDS34910.1 [Q15369-1]
CCDS56539.1 [Q15369-2]
RefSeqiNP_001191786.1, NM_001204857.1 [Q15369-1]
NP_001191787.1, NM_001204858.1 [Q15369-1]
NP_001191788.1, NM_001204859.1 [Q15369-1]
NP_001191789.1, NM_001204860.1 [Q15369-1]
NP_001191790.1, NM_001204861.1 [Q15369-1]
NP_001191791.1, NM_001204862.1 [Q15369-1]
NP_001191792.1, NM_001204863.1 [Q15369-2]
NP_001191793.1, NM_001204864.1 [Q15369-2]
NP_005639.1, NM_005648.3 [Q15369-1]
XP_011515882.1, XM_011517580.2 [Q15369-1]
XP_011515883.1, XM_011517581.2 [Q15369-1]
UniGeneiHs.533437
Hs.554594
Hs.731928

Genome annotation databases

EnsembliENST00000284811; ENSP00000284811; ENSG00000154582 [Q15369-1]
ENST00000518127; ENSP00000428334; ENSG00000154582 [Q15369-1]
ENST00000519487; ENSP00000429596; ENSG00000154582 [Q15369-1]
ENST00000520210; ENSP00000430224; ENSG00000154582 [Q15369-2]
ENST00000520242; ENSP00000428171; ENSG00000154582 [Q15369-1]
ENST00000522337; ENSP00000429906; ENSG00000154582 [Q15369-1]
ENST00000523815; ENSP00000428074; ENSG00000154582 [Q15369-1]
ENST00000622804; ENSP00000478121; ENSG00000154582 [Q15369-1]
GeneIDi6921
KEGGihsa:6921
UCSCiuc003xzx.3 human [Q15369-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiELOC_HUMAN
AccessioniPrimary (citable) accession number: Q15369
Secondary accession number(s): E5RGD9, Q567Q6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2003
Last sequence update: November 1, 1996
Last modified: June 20, 2018
This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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