ELOC

Functionⁱ

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).By similarity1 Publication

The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.4 Publications

GO - Biological processⁱ

positive regulation of transcription elongation from RNA polymerase II promoter Source: GO_Central
post-translational protein modification Source: Reactome
protein ubiquitination Source: Reactome
protein ubiquitination involved in ubiquitin-dependent protein catabolic process Source: GO_Central
regulation of transcription from RNA polymerase II promoter
Source: ProtInc
Traceable author statementⁱ
- 7660129
regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
transcription elongation from RNA polymerase II promoter Source: Reactome
transcription from RNA polymerase II promoter Source: Reactome
viral process Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Biological process	Host-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway

Biological process

Host-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112382. Formation of RNA Pol II elongation complex. R-HSA-112387. Elongation arrest and recovery. R-HSA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha. R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat. R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat. R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation. R-HSA-167243. Tat-mediated HIV elongation arrest and recovery. R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript. R-HSA-167287. HIV elongation arrest and recovery. R-HSA-167290. Pausing and recovery of HIV elongation. R-HSA-180585. Vif-mediated degradation of APOBEC3G. R-HSA-674695. RNA Polymerase II Pre-transcription Events. R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-HSA-75955. RNA Polymerase II Transcription Elongation. R-HSA-8951664. Neddylation. R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SIGNORⁱ	Q15369.

Reactomeⁱ

R-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat.
R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat.
R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation.
R-HSA-167243. Tat-mediated HIV elongation arrest and recovery.
R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript.
R-HSA-167287. HIV elongation arrest and recovery.
R-HSA-167290. Pausing and recovery of HIV elongation.
R-HSA-180585. Vif-mediated degradation of APOBEC3G.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-75955. RNA Polymerase II Transcription Elongation.
R-HSA-8951664. Neddylation.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

SIGNORⁱ

Q15369.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Elongin-C Short name: EloC Alternative name(s): Elongin 15 kDa subunit RNA polymerase II transcription factor SIII subunit C SIII p15 Transcription elongation factor B polypeptide 1
Gene namesⁱ	Name:ELOCImported Synonyms:TCEB1Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11617. ELOC.

HGNCⁱ

HGNC:11617. ELOC.

Subcellular locationⁱ

Nucleus Curated

GO - Cellular componentⁱ

cytosol Source: Reactome
elongin complex Source: GO_Central
nucleoplasm Source: Reactome

Complete GO annotation...

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6921.
Open Targets More...OpenTargetsⁱ	ENSG00000154582.
PharmGKBⁱ	PA36376.

Chemistry databases

ChEMBLⁱ	CHEMBL3301400.

ChEMBLⁱ

CHEMBL3301400.

Polymorphism and mutation databases

BioMutaⁱ	TCEB1.
DMDMⁱ	32699511.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000187258	1 – 112	Elongin-CAdd BLAST		112

Proteomic databases

EPDⁱ	Q15369.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15369.
PaxDbⁱ	Q15369.
PeptideAtlas More...PeptideAtlasⁱ	Q15369.
PRIDEⁱ	Q15369.
TopDownProteomicsⁱ	Q15369-1. [Q15369-1]

PTM databases

iPTMnetⁱ	Q15369.
PhosphoSitePlusⁱ	Q15369.
SwissPalmⁱ	Q15369.

Expressionⁱ

Tissue specificityⁱ

Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000154582.
CleanExⁱ	HS_TCEB1.
ExpressionAtlasⁱ	Q15369. baseline and differential.
Genevisibleⁱ	Q15369. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA078113.

HPAⁱ

HPA078113.

Interactionⁱ

Subunit structureⁱ

Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit (PubMed:17997974). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (By similarity). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, ELOA, VHL or WSB1 (PubMed:15590694). The elongin BC complex is part of a complex with hydroxylated HIF1A (PubMed:12050673, PubMed:12004076). Interacts with VHL (PubMed:10205047, PubMed:12050673). Interacts with TMF1 (PubMed:15467733). Interacts with SPSB1 (PubMed:17189197). posed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2 (PubMed:11006129, PubMed:10205047, PubMed:12050673). Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component (PubMed:23102700).By similarity9 Publications

(Microbial infection) Substrate adapter protein can be a viral protein such as HIV Vif.1 Publication

(Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein NS1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
COMMD1	Q8N668	2	EBI-301231,EBI-1550112
CUL2	Q13617	6	EBI-301231,EBI-456179
ELOB	Q15370	15	EBI-301231,EBI-301238
GAMMAHV.ORF73	O41974	2	EBI-301231,EBI-6933128	From Murid herpesvirus 4.
MED8	Q96G25	3	EBI-301231,EBI-394405
METTL21C	Q5VZV1	5	EBI-301231,EBI-10236049
SOCS1	O15524	2	EBI-301231,EBI-968198
SOCS2	O14508	2	EBI-301231,EBI-617737
SPSB2	Q99619	3	EBI-301231,EBI-2323209
SPSB4	Q96A44	2	EBI-301231,EBI-2323233
vif	P12504	5	EBI-301231,EBI-779991	From Human immunodeficiency virus type 1 group M subtype B (isolate NY5).

Show more details

Protein-protein interaction databases

BioGridⁱ	112783. 151 interactors.
Database of interacting proteins More...DIPⁱ	DIP-29571N.
IntActⁱ	Q15369. 58 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1323870.
STRINGⁱ	9606.ENSP00000284811.

Chemistry databases

BindingDBⁱ

Q15369.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	18 – 22	Combined sources	5
Beta strandⁱ	24 – 26	Combined sources	3
Beta strandⁱ	28 – 32	Combined sources	5
Helixⁱ	33 – 36	Combined sources	4
Helixⁱ	40 – 46	Combined sources	7
Beta strandⁱ	47 – 50	Combined sources	4
Turnⁱ	51 – 54	Combined sources	4
Beta strandⁱ	59 – 61	Combined sources	3
Beta strandⁱ	63 – 65	Combined sources	3
Helixⁱ	67 – 83	Combined sources	17
Turnⁱ	84 – 86	Combined sources	3
Helixⁱ	97 – 99	Combined sources	3
Helixⁱ	100 – 110	Combined sources	11

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LM8	X-ray	1.85	C	17-112	[»]
	1LQB	X-ray	2.00	B	17-112	[»]
	1VCB	X-ray	2.70	B/E/H/K	1-112	[»]
	2C9W	X-ray	1.90	C	17-112	[»]
	2IZV	X-ray	2.55	C	17-112	[»]
	2MA9	NMR	-	C	19-109	[»]
	3DCG	X-ray	2.40	B/D	17-112	[»]
	3ZKJ	X-ray	2.58	B/E	17-112	[»]
	3ZNG	X-ray	2.85	B/E	17-112	[»]
	3ZRC	X-ray	2.90	B/E/H/K	17-112	[»]
	3ZRF	X-ray	2.80	B/E/H/K	17-112	[»]
	3ZTC	X-ray	2.65	B/E/H/K	17-112	[»]
	3ZTD	X-ray	2.79	B/E/H/K	17-112	[»]
	3ZUN	X-ray	2.50	B/E/H/K	17-112	[»]
	4AJY	X-ray	1.73	C	17-112	[»]
	4AWJ	X-ray	2.50	B/E/H/K	17-112	[»]
	4B95	X-ray	2.80	B/E/H/K	18-112	[»]
	4B9K	X-ray	2.00	B/E/H/K	17-112	[»]
	4BKS	X-ray	2.20	B/E/H/K	17-112	[»]
	4BKT	X-ray	2.35	B/E/H/K	17-112	[»]
	4N9F	X-ray	3.30	5/B/E/K/Q/T/Y/Z/h/n/t/z	17-112	[»]
	4W9C	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9D	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9E	X-ray	2.60	B/E/H/K	17-112	[»]
	4W9F	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9G	X-ray	2.70	B/E/H/K	17-112	[»]
	4W9H	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9I	X-ray	2.40	B/E/H/K	17-112	[»]
	4W9J	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9K	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9L	X-ray	2.20	B/E/H/K	17-112	[»]
	4WQO	X-ray	3.20	C	17-112	[»]
	5BO4	X-ray	2.90	C/F/I/L/O/R	17-112	[»]
	5LLI	X-ray	2.40	B/E/H/K	17-112	[»]
	5T35	X-ray	2.70	C/G	17-112	[»]
ProteinModelPortalⁱ	Q15369.
SMRⁱ	Q15369.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q15369.

EvolutionaryTraceⁱ

Q15369.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SKP1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3473. Eukaryota. ENOG41123WR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011717.
HOGENOMⁱ	HOG000216525.
HOVERGENⁱ	HBG007440.
InParanoidⁱ	Q15369.
KEGG Orthology (KO) More...KOⁱ	K03872.
OMAⁱ	DMDIPVE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0W26.
PhylomeDBⁱ	Q15369.
TreeFamⁱ	TF300233.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001232. SKP1-like. IPR011333. SKP1/BTB/POZ. IPR016073. Skp1_comp_POZ.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03931. Skp1_POZ. 1 hit.
SMARTⁱ	View protein in SMART SM00512. Skp1. 1 hit.
SUPFAMⁱ	SSF54695. SSF54695. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q15369-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG 
        60         70         80         90        100
QFAENETNEV NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA 
       110 
LELLMAANFL DC

Length:112

Mass (Da):12,473

Last modified:November 1, 1996 - v1

Checksum:ⁱ98D88696E883538B

GO

Isoform 2 (identifier: Q15369-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-16: Missing.

« Hide

        10         20         30         40         50
MYVKLISSDG HEFIVKREHA LTSGTIKAML SGPGQFAENE TNEVNFREIP 
        60         70         80         90 
SHVLSKVCMY FTYKVRYTNS STEIPEFPIA PEIALELLMA ANFLDC

Note: No experimental confirmation available.

Show »

Length:96

Mass (Da):10,832

Checksum:ⁱ749EC1F8EC3DB62E

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045955	1 – 16	Missing in isoform 2. 1 PublicationAdd BLAST		16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L34587 mRNA. Translation: AAA67650.1. BX649138 mRNA. No translation available. AC022868 Genomic DNA. No translation available. BC013809 mRNA. Translation: AAH13809.1. BC093065 mRNA. Translation: AAH93065.1. BC100028 mRNA. Translation: AAI00029.1. BC100283 mRNA. Translation: AAI00284.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34910.1. [Q15369-1] CCDS56539.1. [Q15369-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001191786.1. NM_001204857.1. [Q15369-1] NP_001191787.1. NM_001204858.1. [Q15369-1] NP_001191788.1. NM_001204859.1. [Q15369-1] NP_001191789.1. NM_001204860.1. [Q15369-1] NP_001191790.1. NM_001204861.1. [Q15369-1] NP_001191791.1. NM_001204862.1. [Q15369-1] NP_001191792.1. NM_001204863.1. [Q15369-2] NP_001191793.1. NM_001204864.1. [Q15369-2] NP_005639.1. NM_005648.3. [Q15369-1] XP_011515882.1. XM_011517580.2. [Q15369-1] XP_011515883.1. XM_011517581.2. [Q15369-1]
UniGeneⁱ	Hs.533437. Hs.554594. Hs.731928.

Genome annotation databases

Ensemblⁱ	ENST00000284811; ENSP00000284811; ENSG00000154582. [Q15369-1] ENST00000518127; ENSP00000428334; ENSG00000154582. [Q15369-1] ENST00000519487; ENSP00000429596; ENSG00000154582. [Q15369-1] ENST00000520210; ENSP00000430224; ENSG00000154582. [Q15369-2] ENST00000520242; ENSP00000428171; ENSG00000154582. [Q15369-1] ENST00000522337; ENSP00000429906; ENSG00000154582. [Q15369-1] ENST00000523815; ENSP00000428074; ENSG00000154582. [Q15369-1] ENST00000622804; ENSP00000478121; ENSG00000154582. [Q15369-1]
GeneIDⁱ	6921.
KEGGⁱ	hsa:6921.
UCSC genome browser More...UCSCⁱ	uc003xzx.3. human. [Q15369-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L34587 mRNA. Translation: AAA67650.1. BX649138 mRNA. No translation available. AC022868 Genomic DNA. No translation available. BC013809 mRNA. Translation: AAH13809.1. BC093065 mRNA. Translation: AAH93065.1. BC100028 mRNA. Translation: AAI00029.1. BC100283 mRNA. Translation: AAI00284.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34910.1. [Q15369-1] CCDS56539.1. [Q15369-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001191786.1. NM_001204857.1. [Q15369-1] NP_001191787.1. NM_001204858.1. [Q15369-1] NP_001191788.1. NM_001204859.1. [Q15369-1] NP_001191789.1. NM_001204860.1. [Q15369-1] NP_001191790.1. NM_001204861.1. [Q15369-1] NP_001191791.1. NM_001204862.1. [Q15369-1] NP_001191792.1. NM_001204863.1. [Q15369-2] NP_001191793.1. NM_001204864.1. [Q15369-2] NP_005639.1. NM_005648.3. [Q15369-1] XP_011515882.1. XM_011517580.2. [Q15369-1] XP_011515883.1. XM_011517581.2. [Q15369-1]
UniGeneⁱ	Hs.533437. Hs.554594. Hs.731928.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LM8	X-ray	1.85	C	17-112	[»]
	1LQB	X-ray	2.00	B	17-112	[»]
	1VCB	X-ray	2.70	B/E/H/K	1-112	[»]
	2C9W	X-ray	1.90	C	17-112	[»]
	2IZV	X-ray	2.55	C	17-112	[»]
	2MA9	NMR	-	C	19-109	[»]
	3DCG	X-ray	2.40	B/D	17-112	[»]
	3ZKJ	X-ray	2.58	B/E	17-112	[»]
	3ZNG	X-ray	2.85	B/E	17-112	[»]
	3ZRC	X-ray	2.90	B/E/H/K	17-112	[»]
	3ZRF	X-ray	2.80	B/E/H/K	17-112	[»]
	3ZTC	X-ray	2.65	B/E/H/K	17-112	[»]
	3ZTD	X-ray	2.79	B/E/H/K	17-112	[»]
	3ZUN	X-ray	2.50	B/E/H/K	17-112	[»]
	4AJY	X-ray	1.73	C	17-112	[»]
	4AWJ	X-ray	2.50	B/E/H/K	17-112	[»]
	4B95	X-ray	2.80	B/E/H/K	18-112	[»]
	4B9K	X-ray	2.00	B/E/H/K	17-112	[»]
	4BKS	X-ray	2.20	B/E/H/K	17-112	[»]
	4BKT	X-ray	2.35	B/E/H/K	17-112	[»]
	4N9F	X-ray	3.30	5/B/E/K/Q/T/Y/Z/h/n/t/z	17-112	[»]
	4W9C	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9D	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9E	X-ray	2.60	B/E/H/K	17-112	[»]
	4W9F	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9G	X-ray	2.70	B/E/H/K	17-112	[»]
	4W9H	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9I	X-ray	2.40	B/E/H/K	17-112	[»]
	4W9J	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9K	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9L	X-ray	2.20	B/E/H/K	17-112	[»]
	4WQO	X-ray	3.20	C	17-112	[»]
	5BO4	X-ray	2.90	C/F/I/L/O/R	17-112	[»]
	5LLI	X-ray	2.40	B/E/H/K	17-112	[»]
	5T35	X-ray	2.70	C/G	17-112	[»]
ProteinModelPortalⁱ	Q15369.
SMRⁱ	Q15369.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112783. 151 interactors.
Database of interacting proteins More...DIPⁱ	DIP-29571N.
IntActⁱ	Q15369. 58 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-1323870.
STRINGⁱ	9606.ENSP00000284811.

Chemistry databases

BindingDBⁱ	Q15369.
ChEMBLⁱ	CHEMBL3301400.

PTM databases

iPTMnetⁱ	Q15369.
PhosphoSitePlusⁱ	Q15369.
SwissPalmⁱ	Q15369.

Polymorphism and mutation databases

BioMutaⁱ	TCEB1.
DMDMⁱ	32699511.

Proteomic databases

EPDⁱ	Q15369.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15369.
PaxDbⁱ	Q15369.
PeptideAtlas More...PeptideAtlasⁱ	Q15369.
PRIDEⁱ	Q15369.
TopDownProteomicsⁱ	Q15369-1. [Q15369-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6921.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000284811; ENSP00000284811; ENSG00000154582. [Q15369-1] ENST00000518127; ENSP00000428334; ENSG00000154582. [Q15369-1] ENST00000519487; ENSP00000429596; ENSG00000154582. [Q15369-1] ENST00000520210; ENSP00000430224; ENSG00000154582. [Q15369-2] ENST00000520242; ENSP00000428171; ENSG00000154582. [Q15369-1] ENST00000522337; ENSP00000429906; ENSG00000154582. [Q15369-1] ENST00000523815; ENSP00000428074; ENSG00000154582. [Q15369-1] ENST00000622804; ENSP00000478121; ENSG00000154582. [Q15369-1]
GeneIDⁱ	6921.
KEGGⁱ	hsa:6921.
UCSC genome browser More...UCSCⁱ	uc003xzx.3. human. [Q15369-1]

Organism-specific databases

CTDⁱ	6921.
DisGeNET More...DisGeNETⁱ	6921.
GeneCardsⁱ	TCEB1.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11617. ELOC.
Human Protein Atlas More...HPAⁱ	HPA078113.
MIMⁱ	600788. gene.
neXtProtⁱ	NX_Q15369.
Open Targets More...OpenTargetsⁱ	ENSG00000154582.
PharmGKBⁱ	PA36376.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3473. Eukaryota. ENOG41123WR. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011717.
HOGENOMⁱ	HOG000216525.
HOVERGENⁱ	HBG007440.
InParanoidⁱ	Q15369.
KEGG Orthology (KO) More...KOⁱ	K03872.
OMAⁱ	DMDIPVE.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0W26.
PhylomeDBⁱ	Q15369.
TreeFamⁱ	TF300233.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112382. Formation of RNA Pol II elongation complex. R-HSA-112387. Elongation arrest and recovery. R-HSA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha. R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat. R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat. R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation. R-HSA-167243. Tat-mediated HIV elongation arrest and recovery. R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript. R-HSA-167287. HIV elongation arrest and recovery. R-HSA-167290. Pausing and recovery of HIV elongation. R-HSA-180585. Vif-mediated degradation of APOBEC3G. R-HSA-674695. RNA Polymerase II Pre-transcription Events. R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes. R-HSA-75955. RNA Polymerase II Transcription Elongation. R-HSA-8951664. Neddylation. R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
SIGNORⁱ	Q15369.

Reactomeⁱ

R-HSA-112382. Formation of RNA Pol II elongation complex.
R-HSA-112387. Elongation arrest and recovery.
R-HSA-1234176. Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.
R-HSA-167152. Formation of HIV elongation complex in the absence of HIV Tat.
R-HSA-167200. Formation of HIV-1 elongation complex containing HIV-1 Tat.
R-HSA-167238. Pausing and recovery of Tat-mediated HIV elongation.
R-HSA-167243. Tat-mediated HIV elongation arrest and recovery.
R-HSA-167246. Tat-mediated elongation of the HIV-1 transcript.
R-HSA-167287. HIV elongation arrest and recovery.
R-HSA-167290. Pausing and recovery of HIV elongation.
R-HSA-180585. Vif-mediated degradation of APOBEC3G.
R-HSA-674695. RNA Polymerase II Pre-transcription Events.
R-HSA-6796648. TP53 Regulates Transcription of DNA Repair Genes.
R-HSA-75955. RNA Polymerase II Transcription Elongation.
R-HSA-8951664. Neddylation.
R-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

SIGNORⁱ

Q15369.

Miscellaneous databases

ChiTaRSⁱ	TCEB1. human.
EvolutionaryTraceⁱ	Q15369.
GeneWikiⁱ	TCEB1.
GenomeRNAiⁱ	6921.
Protein Ontology More...PROⁱ	PR:Q15369.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000154582.
CleanExⁱ	HS_TCEB1.
ExpressionAtlasⁱ	Q15369. baseline and differential.
Genevisibleⁱ	Q15369. HS.

Family and domain databases

InterProⁱ	View protein in InterPro IPR001232. SKP1-like. IPR011333. SKP1/BTB/POZ. IPR016073. Skp1_comp_POZ.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03931. Skp1_POZ. 1 hit.
SMARTⁱ	View protein in SMART SM00512. Skp1. 1 hit.
SUPFAMⁱ	SSF54695. SSF54695. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ELOC_HUMAN
Accessionⁱ	Q15369Primary (citable) accession number: Q15369 Secondary accession number(s): E5RGD9, Q567Q6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
	Last sequence update:	November 1, 1996
	Last modified:	July 5, 2017
	This is version 174 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 8
Human chromosome 8: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q15369 (ELOC_HUMAN)

Your basket is currently empty.

Elongin-C

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ