ELOC

Functionⁱ

SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex) (PubMed:7821821). In embryonic stem cells, the elongin BC complex is recruited by EPOP to Polycomb group (PcG) target genes in order generate genomic region that display both active and repressive chromatin properties, an important feature of pluripotent stem cells (By similarity).By similarity1 Publication

The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.4 Publications

GO - Biological processⁱ

positive regulation of transcription elongation from RNA polymerase II promoter Source: GO_Central
post-translational protein modification Source: Reactome
protein ubiquitination Source: GOC
regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 7660129
regulation of transcription from RNA polymerase II promoter in response to hypoxia Source: Reactome
transcription by RNA polymerase II Source: Reactome
transcription elongation from RNA polymerase II promoter Source: Reactome
ubiquitin-dependent protein catabolic process Source: InterPro
viral process Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Host-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway

Biological process

Host-virus interaction, Transcription, Transcription regulation, Ubl conjugation pathway

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation R-HSA-167243 Tat-mediated HIV elongation arrest and recovery R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript R-HSA-167287 HIV elongation arrest and recovery R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-180585 Vif-mediated degradation of APOBEC3G R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-8951664 Neddylation R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORⁱ	Q15369

Reactomeⁱ

R-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SIGNORⁱ

Q15369

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Elongin-C Short name: EloC Alternative name(s): Elongin 15 kDa subunit RNA polymerase II transcription factor SIII subunit C SIII p15 Transcription elongation factor B polypeptide 1
Gene namesⁱ	Name:ELOCImported Synonyms:TCEB1Imported
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 8

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000154582.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11617 ELOC
MIMⁱ	600788 gene
neXtProtⁱ	NX_Q15369

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6921
Open Targets More...OpenTargetsⁱ	ENSG00000154582
PharmGKBⁱ	PA36376

Chemistry databases

ChEMBLⁱ	CHEMBL3301400

ChEMBLⁱ

CHEMBL3301400

Polymorphism and mutation databases

BioMutaⁱ	TCEB1
DMDMⁱ	32699511

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000187258	1 – 112	Elongin-CAdd BLAST		112

Proteomic databases

EPDⁱ	Q15369
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15369
PaxDbⁱ	Q15369
PeptideAtlas More...PeptideAtlasⁱ	Q15369
PRIDEⁱ	Q15369
ProteomicsDBⁱ	60547
TopDownProteomicsⁱ	Q15369-1 [Q15369-1]

PTM databases

iPTMnetⁱ	Q15369
PhosphoSitePlusⁱ	Q15369
SwissPalmⁱ	Q15369

Expressionⁱ

Tissue specificityⁱ

Overexpressed in prostate cancer cell line PC-3 and breast cancer cell line SK-BR-3.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000154582
CleanExⁱ	HS_TCEB1
ExpressionAtlasⁱ	Q15369 baseline and differential
Genevisibleⁱ	Q15369 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA078113

HPAⁱ

HPA078113

Interactionⁱ

Subunit structureⁱ

Heterotrimer of an A (ELOA, ELOA2 or ELOA3), ELOB and ELOC subunit (PubMed:17997974). The elongin BC complex interacts with EPOP; leading to recruit the elongin BC complex to Polycomb group (PcG) target genes, thereby restricting excessive activity of the PRC2/EED-EZH2 complex (By similarity). Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, SOCS5, ELOA, VHL or WSB1 (PubMed:15590694). The elongin BC complex is part of a complex with hydroxylated HIF1A (PubMed:12050673, PubMed:12004076). Interacts with VHL (PubMed:10205047, PubMed:12050673). Interacts with TMF1 (PubMed:15467733). Interacts with SPSB1 (PubMed:17189197). posed of LIMD1, VHL, EGLN1/PHD2, ELOB and CUL2 (PubMed:11006129, PubMed:10205047, PubMed:12050673). Interacts with SPSB1. Interacts with KLHDC10; which may be an E3 ubiquitin ligase complex substrate recognition component (PubMed:23102700).By similarity9 Publications

(Microbial infection) Substrate adapter protein can be a viral protein such as HIV Vif.1 Publication

(Microbial infection) Interacts with human respiratory syncytial virus (HRSV) protein NS1.1 Publication

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
COMMD1	Q8N668	2	EBI-301231,EBI-1550112
CUL2	Q13617	6	EBI-301231,EBI-456179
ELOB	Q15370	15	EBI-301231,EBI-301238
GAMMAHV.ORF73	O41974	2	EBI-301231,EBI-6933128	From Murid herpesvirus 4.
MED8	Q96G25	3	EBI-301231,EBI-394405
METTL21C	Q5VZV1	5	EBI-301231,EBI-10236049
SOCS1	O15524	2	EBI-301231,EBI-968198
SOCS2	O14508	2	EBI-301231,EBI-617737
SPSB2	Q99619	3	EBI-301231,EBI-2323209
SPSB4	Q96A44	2	EBI-301231,EBI-2323233
vif	P12504	5	EBI-301231,EBI-779991	From Human immunodeficiency virus type 1 group M subtype B (isolate NY5).

Show more details

Protein-protein interaction databases

BioGridⁱ	112783, 153 interactors
CORUMⁱ	Q15369
Database of interacting proteins More...DIPⁱ	DIP-29571N
IntActⁱ	Q15369, 61 interactors
Molecular INTeraction database More...MINTⁱ	Q15369
STRINGⁱ	9606.ENSP00000284811

Chemistry databases

BindingDBⁱ

Q15369

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	18 – 22	Combined sources	5
Beta strandⁱ	24 – 26	Combined sources	3
Beta strandⁱ	28 – 32	Combined sources	5
Helixⁱ	33 – 36	Combined sources	4
Helixⁱ	40 – 46	Combined sources	7
Beta strandⁱ	47 – 50	Combined sources	4
Turnⁱ	51 – 54	Combined sources	4
Beta strandⁱ	59 – 61	Combined sources	3
Beta strandⁱ	63 – 65	Combined sources	3
Helixⁱ	67 – 83	Combined sources	17
Turnⁱ	84 – 86	Combined sources	3
Helixⁱ	97 – 99	Combined sources	3
Helixⁱ	100 – 110	Combined sources	11

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LM8	X-ray	1.85	C	17-112	[»]
	1LQB	X-ray	2.00	B	17-112	[»]
	1VCB	X-ray	2.70	B/E/H/K	1-112	[»]
	2C9W	X-ray	1.90	C	17-112	[»]
	2IZV	X-ray	2.55	C	17-112	[»]
	2MA9	NMR	-	C	19-109	[»]
	3DCG	X-ray	2.40	B/D	17-112	[»]
	3ZKJ	X-ray	2.58	B/E	17-112	[»]
	3ZNG	X-ray	2.85	B/E	17-112	[»]
	3ZRC	X-ray	2.90	B/E/H/K	17-112	[»]
	3ZRF	X-ray	2.80	B/E/H/K	17-112	[»]
	3ZTC	X-ray	2.65	B/E/H/K	17-112	[»]
	3ZTD	X-ray	2.79	B/E/H/K	17-112	[»]
	3ZUN	X-ray	2.50	B/E/H/K	17-112	[»]
	4AJY	X-ray	1.73	C	17-112	[»]
	4AWJ	X-ray	2.50	B/E/H/K	17-112	[»]
	4B95	X-ray	2.80	B/E/H/K	18-112	[»]
	4B9K	X-ray	2.00	B/E/H/K	17-112	[»]
	4BKS	X-ray	2.20	B/E/H/K	17-112	[»]
	4BKT	X-ray	2.35	B/E/H/K	17-112	[»]
	4N9F	X-ray	3.30	5/B/E/K/Q/T/Y/Z/h/n/t/z	17-112	[»]
	4W9C	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9D	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9E	X-ray	2.60	B/E/H/K	17-112	[»]
	4W9F	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9G	X-ray	2.70	B/E/H/K	17-112	[»]
	4W9H	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9I	X-ray	2.40	B/E/H/K	17-112	[»]
	4W9J	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9K	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9L	X-ray	2.20	B/E/H/K	17-112	[»]
	4WQO	X-ray	3.20	C	17-112	[»]
	5BO4	X-ray	2.90	C/F/I/L/O/R	17-112	[»]
	5LLI	X-ray	2.40	B/E/H/K	17-112	[»]
	5N4W	X-ray	3.90	C	17-112	[»]
	5NVV	X-ray	2.10	B/E/H/K	17-112	[»]
	5NVW	X-ray	2.20	B/E/H/K	17-112	[»]
	5NVX	X-ray	2.20	B/E/H/K	17-112	[»]
	5NVY	X-ray	2.90	B/E/H/K	17-112	[»]
	5NVZ	X-ray	2.70	B/E/H/K	17-112	[»]
	5NW0	X-ray	2.30	B/E/H/K	17-112	[»]
	5NW1	X-ray	2.10	B/E/H/K	17-112	[»]
	5NW2	X-ray	2.20	B/E/H/K	17-112	[»]
	5T35	X-ray	2.70	C/G	17-112	[»]
	6C5X	X-ray	3.10	C/F	17-112	[»]
	6FMI	X-ray	2.80	B/E	17-112	[»]
	6FMJ	X-ray	2.45	B/E/H/K	17-112	[»]
	6FMK	X-ray	2.75	B/E/H/K	17-112	[»]
ProteinModelPortalⁱ	Q15369
SMRⁱ	Q15369
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	Q15369

EvolutionaryTraceⁱ

Q15369

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the SKP1 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG3473 Eukaryota ENOG41123WR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011717
HOGENOMⁱ	HOG000216525
HOVERGENⁱ	HBG007440
InParanoidⁱ	Q15369
KEGG Orthology (KO) More...KOⁱ	K03872
OMAⁱ	DMDIPVE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0W26
PhylomeDBⁱ	Q15369
TreeFamⁱ	TF300233

Family and domain databases

InterProⁱ	View protein in InterPro IPR001232 SKP1-like IPR011333 SKP1/BTB/POZ_sf IPR016073 Skp1_comp_POZ
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03931 Skp1_POZ, 1 hit
SMARTⁱ	View protein in SMART SM00512 Skp1, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform 1 (identifier: Q15369-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDGEEKTYGG CEGPDAMYVK LISSDGHEFI VKREHALTSG TIKAMLSGPG 
        60         70         80         90        100
QFAENETNEV NFREIPSHVL SKVCMYFTYK VRYTNSSTEI PEFPIAPEIA 
       110 
LELLMAANFL DC

Length:112

Mass (Da):12,473

Last modified:November 1, 1996 - v1

Checksum:ⁱ98D88696E883538B

GO

Isoform 2 (identifier: Q15369-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-16: Missing.

« Hide

        10         20         30         40         50
MYVKLISSDG HEFIVKREHA LTSGTIKAML SGPGQFAENE TNEVNFREIP 
        60         70         80         90 
SHVLSKVCMY FTYKVRYTNS STEIPEFPIA PEIALELLMA ANFLDC

Note: No experimental confirmation available.

Show »

Length:96

Mass (Da):10,832

Checksum:ⁱ749EC1F8EC3DB62E

GO

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_045955	1 – 16	Missing in isoform 2. 1 PublicationAdd BLAST		16

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L34587 mRNA Translation: AAA67650.1 BX649138 mRNA No translation available. AC022868 Genomic DNA No translation available. BC013809 mRNA Translation: AAH13809.1 BC093065 mRNA Translation: AAH93065.1 BC100028 mRNA Translation: AAI00029.1 BC100283 mRNA Translation: AAI00284.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34910.1 [Q15369-1] CCDS56539.1 [Q15369-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001191786.1, NM_001204857.1 [Q15369-1] NP_001191787.1, NM_001204858.1 [Q15369-1] NP_001191788.1, NM_001204859.1 [Q15369-1] NP_001191789.1, NM_001204860.1 [Q15369-1] NP_001191790.1, NM_001204861.1 [Q15369-1] NP_001191791.1, NM_001204862.1 [Q15369-1] NP_001191792.1, NM_001204863.1 [Q15369-2] NP_001191793.1, NM_001204864.1 [Q15369-2] NP_005639.1, NM_005648.3 [Q15369-1] XP_011515882.1, XM_011517580.2 [Q15369-1] XP_011515883.1, XM_011517581.2 [Q15369-1]
UniGeneⁱ	Hs.533437 Hs.554594 Hs.731928

Genome annotation databases

Ensemblⁱ	ENST00000284811; ENSP00000284811; ENSG00000154582 [Q15369-1] ENST00000518127; ENSP00000428334; ENSG00000154582 [Q15369-1] ENST00000519487; ENSP00000429596; ENSG00000154582 [Q15369-1] ENST00000520210; ENSP00000430224; ENSG00000154582 [Q15369-2] ENST00000520242; ENSP00000428171; ENSG00000154582 [Q15369-1] ENST00000522337; ENSP00000429906; ENSG00000154582 [Q15369-1] ENST00000523815; ENSP00000428074; ENSG00000154582 [Q15369-1] ENST00000622804; ENSP00000478121; ENSG00000154582 [Q15369-1]
GeneIDⁱ	6921
KEGGⁱ	hsa:6921
UCSC genome browser More...UCSCⁱ	uc003xzx.3 human [Q15369-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
Q15369	Elongin-C		BOVIN		112
Elongin-C	)	MOUSE		112
Elongin-C		RAT		112
Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), isoform CRA_a		HUMAN		112
Transcription elongation factor B polypeptide 1 isoform a		CALJA		112
+60
Q15369-2	Uncharacterized protein		SHEEP		249
Elongin C paralog b		LEPOC		90
Transcription elongation factor B polypeptide 1 (Fragment)		golden-collared manakin		63
Uncharacterized protein		OTOGA		110
Elongin C		TAEGU		110
+17

Protein	Similar proteins		Species	Score	Length
Q15369	Elongin-C		BOVIN		112
Elongin-C	)	MOUSE		112
Elongin-C		RAT		112
Transcription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C), isoform CRA_a		HUMAN		112
Transcription elongation factor B polypeptide 1 isoform a		CALJA		112
+87
Q15369-2	Uncharacterized protein		SHEEP		249
Elongin C paralog b		LEPOC		90
Transcription elongation factor B polypeptide 1 (Fragment)		golden-collared manakin		63
Uncharacterized protein		OTOGA		110
Elongin C		TAEGU		110
+18

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L34587 mRNA Translation: AAA67650.1 BX649138 mRNA No translation available. AC022868 Genomic DNA No translation available. BC013809 mRNA Translation: AAH13809.1 BC093065 mRNA Translation: AAH93065.1 BC100028 mRNA Translation: AAI00029.1 BC100283 mRNA Translation: AAI00284.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS34910.1 [Q15369-1] CCDS56539.1 [Q15369-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_001191786.1, NM_001204857.1 [Q15369-1] NP_001191787.1, NM_001204858.1 [Q15369-1] NP_001191788.1, NM_001204859.1 [Q15369-1] NP_001191789.1, NM_001204860.1 [Q15369-1] NP_001191790.1, NM_001204861.1 [Q15369-1] NP_001191791.1, NM_001204862.1 [Q15369-1] NP_001191792.1, NM_001204863.1 [Q15369-2] NP_001191793.1, NM_001204864.1 [Q15369-2] NP_005639.1, NM_005648.3 [Q15369-1] XP_011515882.1, XM_011517580.2 [Q15369-1] XP_011515883.1, XM_011517581.2 [Q15369-1]
UniGeneⁱ	Hs.533437 Hs.554594 Hs.731928

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1LM8	X-ray	1.85	C	17-112	[»]
	1LQB	X-ray	2.00	B	17-112	[»]
	1VCB	X-ray	2.70	B/E/H/K	1-112	[»]
	2C9W	X-ray	1.90	C	17-112	[»]
	2IZV	X-ray	2.55	C	17-112	[»]
	2MA9	NMR	-	C	19-109	[»]
	3DCG	X-ray	2.40	B/D	17-112	[»]
	3ZKJ	X-ray	2.58	B/E	17-112	[»]
	3ZNG	X-ray	2.85	B/E	17-112	[»]
	3ZRC	X-ray	2.90	B/E/H/K	17-112	[»]
	3ZRF	X-ray	2.80	B/E/H/K	17-112	[»]
	3ZTC	X-ray	2.65	B/E/H/K	17-112	[»]
	3ZTD	X-ray	2.79	B/E/H/K	17-112	[»]
	3ZUN	X-ray	2.50	B/E/H/K	17-112	[»]
	4AJY	X-ray	1.73	C	17-112	[»]
	4AWJ	X-ray	2.50	B/E/H/K	17-112	[»]
	4B95	X-ray	2.80	B/E/H/K	18-112	[»]
	4B9K	X-ray	2.00	B/E/H/K	17-112	[»]
	4BKS	X-ray	2.20	B/E/H/K	17-112	[»]
	4BKT	X-ray	2.35	B/E/H/K	17-112	[»]
	4N9F	X-ray	3.30	5/B/E/K/Q/T/Y/Z/h/n/t/z	17-112	[»]
	4W9C	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9D	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9E	X-ray	2.60	B/E/H/K	17-112	[»]
	4W9F	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9G	X-ray	2.70	B/E/H/K	17-112	[»]
	4W9H	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9I	X-ray	2.40	B/E/H/K	17-112	[»]
	4W9J	X-ray	2.20	B/E/H/K	17-112	[»]
	4W9K	X-ray	2.10	B/E/H/K	17-112	[»]
	4W9L	X-ray	2.20	B/E/H/K	17-112	[»]
	4WQO	X-ray	3.20	C	17-112	[»]
	5BO4	X-ray	2.90	C/F/I/L/O/R	17-112	[»]
	5LLI	X-ray	2.40	B/E/H/K	17-112	[»]
	5N4W	X-ray	3.90	C	17-112	[»]
	5NVV	X-ray	2.10	B/E/H/K	17-112	[»]
	5NVW	X-ray	2.20	B/E/H/K	17-112	[»]
	5NVX	X-ray	2.20	B/E/H/K	17-112	[»]
	5NVY	X-ray	2.90	B/E/H/K	17-112	[»]
	5NVZ	X-ray	2.70	B/E/H/K	17-112	[»]
	5NW0	X-ray	2.30	B/E/H/K	17-112	[»]
	5NW1	X-ray	2.10	B/E/H/K	17-112	[»]
	5NW2	X-ray	2.20	B/E/H/K	17-112	[»]
	5T35	X-ray	2.70	C/G	17-112	[»]
	6C5X	X-ray	3.10	C/F	17-112	[»]
	6FMI	X-ray	2.80	B/E	17-112	[»]
	6FMJ	X-ray	2.45	B/E/H/K	17-112	[»]
	6FMK	X-ray	2.75	B/E/H/K	17-112	[»]
ProteinModelPortalⁱ	Q15369
SMRⁱ	Q15369
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112783, 153 interactors
CORUMⁱ	Q15369
Database of interacting proteins More...DIPⁱ	DIP-29571N
IntActⁱ	Q15369, 61 interactors
Molecular INTeraction database More...MINTⁱ	Q15369
STRINGⁱ	9606.ENSP00000284811

Chemistry databases

BindingDBⁱ	Q15369
ChEMBLⁱ	CHEMBL3301400

PTM databases

iPTMnetⁱ	Q15369
PhosphoSitePlusⁱ	Q15369
SwissPalmⁱ	Q15369

Polymorphism and mutation databases

BioMutaⁱ	TCEB1
DMDMⁱ	32699511

Proteomic databases

EPDⁱ	Q15369
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q15369
PaxDbⁱ	Q15369
PeptideAtlas More...PeptideAtlasⁱ	Q15369
PRIDEⁱ	Q15369
ProteomicsDBⁱ	60547
TopDownProteomicsⁱ	Q15369-1 [Q15369-1]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	6921
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000284811; ENSP00000284811; ENSG00000154582 [Q15369-1] ENST00000518127; ENSP00000428334; ENSG00000154582 [Q15369-1] ENST00000519487; ENSP00000429596; ENSG00000154582 [Q15369-1] ENST00000520210; ENSP00000430224; ENSG00000154582 [Q15369-2] ENST00000520242; ENSP00000428171; ENSG00000154582 [Q15369-1] ENST00000522337; ENSP00000429906; ENSG00000154582 [Q15369-1] ENST00000523815; ENSP00000428074; ENSG00000154582 [Q15369-1] ENST00000622804; ENSP00000478121; ENSG00000154582 [Q15369-1]
GeneIDⁱ	6921
KEGGⁱ	hsa:6921
UCSC genome browser More...UCSCⁱ	uc003xzx.3 human [Q15369-1]

Organism-specific databases

CTDⁱ	6921
DisGeNET More...DisGeNETⁱ	6921
EuPathDBⁱ	HostDB:ENSG00000154582.16
GeneCardsⁱ	ELOC
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11617 ELOC
Human Protein Atlas More...HPAⁱ	HPA078113
MIMⁱ	600788 gene
neXtProtⁱ	NX_Q15369
Open Targets More...OpenTargetsⁱ	ENSG00000154582
PharmGKBⁱ	PA36376
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3473 Eukaryota ENOG41123WR LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000011717
HOGENOMⁱ	HOG000216525
HOVERGENⁱ	HBG007440
InParanoidⁱ	Q15369
KEGG Orthology (KO) More...KOⁱ	K03872
OMAⁱ	DMDIPVE
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0W26
PhylomeDBⁱ	Q15369
TreeFamⁱ	TF300233

Enzyme and pathway databases

Reactomeⁱ	R-HSA-112382 Formation of RNA Pol II elongation complex R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation R-HSA-167243 Tat-mediated HIV elongation arrest and recovery R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript R-HSA-167287 HIV elongation arrest and recovery R-HSA-167290 Pausing and recovery of HIV elongation R-HSA-180585 Vif-mediated degradation of APOBEC3G R-HSA-674695 RNA Polymerase II Pre-transcription Events R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes R-HSA-75955 RNA Polymerase II Transcription Elongation R-HSA-8951664 Neddylation R-HSA-9010553 Regulation of expression of SLITs and ROBOs R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation
SIGNORⁱ	Q15369

Reactomeⁱ

R-HSA-112382 Formation of RNA Pol II elongation complex
R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat
R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat
R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation
R-HSA-167243 Tat-mediated HIV elongation arrest and recovery
R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript
R-HSA-167287 HIV elongation arrest and recovery
R-HSA-167290 Pausing and recovery of HIV elongation
R-HSA-180585 Vif-mediated degradation of APOBEC3G
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes
R-HSA-75955 RNA Polymerase II Transcription Elongation
R-HSA-8951664 Neddylation
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation

SIGNORⁱ

Q15369

Miscellaneous databases

ChiTaRSⁱ	TCEB1 human
EvolutionaryTraceⁱ	Q15369
GeneWikiⁱ	TCEB1
GenomeRNAiⁱ	6921
Protein Ontology More...PROⁱ	PR:Q15369
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000154582
CleanExⁱ	HS_TCEB1
ExpressionAtlasⁱ	Q15369 baseline and differential
Genevisibleⁱ	Q15369 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001232 SKP1-like IPR011333 SKP1/BTB/POZ_sf IPR016073 Skp1_comp_POZ
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03931 Skp1_POZ, 1 hit
SMARTⁱ	View protein in SMART SM00512 Skp1, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ELOC_HUMAN
Accessionⁱ	Q15369Primary (citable) accession number: Q15369 Secondary accession number(s): E5RGD9, Q567Q6
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 11, 2003
	Last sequence update:	November 1, 1996
	Last modified:	June 20, 2018
	This is version 184 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

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UniProtKB - Q15369 (ELOC_HUMAN)

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GO - Biological processⁱ

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