Q15354 (Q15354_HUMAN) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Orf 2 protein EMBL CAA58679.1

Submitted name:
Platelet-derived growth factor beta polypeptide (Simian sarcoma viral (V-sis) oncogene homolog) EMBL CAP58849.1

Gene names

Name:	orf 2 EMBL CAA58679.1
Synonyms:	PDGFB EMBL CAP58849.1
ORF Names:	LL22NC03-10C3.2-002 EMBL CAP58849.1

Organism

Homo sapiens (Human) EMBL CAA58679.1

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	185 AA.
Sequence status	Fragment.
Protein existence	Evidence at transcript level

General annotation (Comments)

Sequence similarities

Belongs to the PDGF/VEGF growth factor family. RuleBase RU003818

Ontologies

Keywords
Molecular function	Growth factor SAAS SAAS000072 RuleBase RU003818 Mitogen RuleBase RU003819
Gene Ontology (GO)
Biological process	positive regulation of cell division Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	membrane Inferred from electronic annotation. Source: InterPro
Molecular function	growth factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Experimental info
	Non-terminal residue	185	1	EMBL CAA58679.1

Sequences

	Sequence		Length	Mass (Da)
	Q15354 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: A2BC585F88DFEE59	FASTA	185	20,774
	10 20 30 40 50 60 MFIMGLGDPI PEELYEMLSD HSIRSFDDLQ RLLHGDPGEE DGAELDLNMT RSHSGGELES 70 80 90 100 110 120 LARGRRSLGS LTIAEPAMIA ECKTRTEVFE ISRRLIDRTN ANFLVWPPCV EVQRCSGCCN 130 140 150 160 170 180 NRNVQCRPTQ VQLRPVQVRK IEIVRKKPIF KKATVTLEDH LACKCETVAA ARPVTRSPGG SQEQR

References

[1]	"A novel human c-sis mRNA species is transcribed from a promoter in c-sis intron 1 and contains the code for an alternative PDGF B-like protein." Dirks R.P.H., Onnekink C., Jansen H.J., de Jong A., Bloemers H.P.J. Nucleic Acids Res. 23:2815-2822(1995) [PubMed: 7659502] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Tissue: Choriocarcinoma EMBL CAA58679.1.
[2]	Burgess J. Submitted (JAN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X83705 mRNA. Translation: CAA58679.1. Z81010 Genomic DNA. Translation: CAP58849.1.
IPI	IPI00334195.
RefSeq	NP_148937.1. NM_033016.2.
UniGene	Hs.1976.
3D structure databases
HSSP	HSSP built from PDB template 1PDG based on UniProtKB P01127.
ModBase	Search...
Protein-protein interaction databases
STRING	Q15354.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5155.
KEGG	hsa:5155.
Organism-specific databases
CTD	5155.
Phylogenomic databases
HOVERGEN	HBG053546.
Gene expression databases
ArrayExpress	Q15354.
Bgee	Q15354.
Family and domain databases
InterPro	IPR000072. PD_growth_factor. IPR023581. PD_growth_factor_CS. IPR006782. PDGF_N. [Graphical view]
KO	K04359.
Pfam	PF00341. PDGF. 1 hit. PF04692. PDGF_N. 1 hit. [Graphical view]
SMART	SM00141. PDGF. 1 hit. [Graphical view]
PROSITE	PS00249. PDGF_1. 1 hit. PS50278. PDGF_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q15354_HUMAN

Accession

Primary (citable) accession number: Q15354

Entry history

Integrated into UniProtKB/TrEMBL:	November 1, 1996
Last sequence update:	November 1, 1996
Last modified:	November 16, 2011
This is version 61 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.