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Protein

Leucine-rich repeat-containing protein 41

Gene

LRRC41

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable substrate recognition component of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.1 Publication

Pathwayi: protein ubiquitination

This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.
View all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Ubl conjugation pathway

Enzyme and pathway databases

ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.
UniPathwayiUPA00143.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 41
Alternative name(s):
Protein Muf1
Gene namesi
Name:LRRC41
Synonyms:MUF1
ORF Names:PP7759
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:16917. LRRC41.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: GO_Central
  • membrane Source: UniProtKB
  • nucleus Source: GO_Central
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000132128.
PharmGKBiPA142671529.

Polymorphism and mutation databases

BioMutaiLRRC41.
DMDMi150421588.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000966451 – 812Leucine-rich repeat-containing protein 41Add BLAST812

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei155PhosphoserineCombined sources1
Modified residuei276PhosphoserineCombined sources1
Modified residuei326PhosphoserineCombined sources1
Modified residuei327PhosphothreonineCombined sources1
Modified residuei357PhosphoserineCombined sources1
Modified residuei373PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ15345.
PaxDbiQ15345.
PeptideAtlasiQ15345.
PRIDEiQ15345.

PTM databases

iPTMnetiQ15345.
PhosphoSitePlusiQ15345.

Expressioni

Gene expression databases

BgeeiENSG00000132128.
CleanExiHS_LRRC41.
ExpressionAtlasiQ15345. baseline and differential.
GenevisibleiQ15345. HS.

Organism-specific databases

HPAiHPA051941.

Interactioni

Subunit structurei

Part of an E3 ubiquitin-protein ligase complex with Elongin BC (TCEB1 and TCEB2), RBX1 and CUL5. Component of a probable ECS(LRRC41) complex which contains CUL5, RNF7/RBX2, Elongin BC and LRRC41. Interacts with CUL5, RNF7, TCEB1 and TCEB2.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi115752. 19 interactors.
IntActiQ15345. 5 interactors.
MINTiMINT-1419045.
STRINGi9606.ENSP00000343298.

Structurei

3D structure databases

ProteinModelPortaliQ15345.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati487 – 507LRR 1Add BLAST21
Repeati518 – 530LRR 2Add BLAST13
Repeati531 – 555LRR 3Add BLAST25
Repeati613 – 635LRR 4Add BLAST23
Repeati636 – 659LRR 5Add BLAST24
Repeati701 – 728LRR 6Add BLAST28
Repeati731 – 752LRR 7Add BLAST22

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni45 – 54Interaction with Elongin BC complexBy similarity10

Domaini

The Elongin BC complex binding domain is also known as BC-box with the consensus [APST]-L-x(3)-C-x(3)-[AILV].

Sequence similaritiesi

Contains 7 LRR (leucine-rich) repeats.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiENOG410IHRR. Eukaryota.
ENOG410YFW5. LUCA.
GeneTreeiENSGT00390000015908.
HOGENOMiHOG000013094.
HOVERGENiHBG102701.
InParanoidiQ15345.
KOiK10347.
OMAiFADYISV.
OrthoDBiEOG091G02TR.
PhylomeDBiQ15345.
TreeFamiTF335481.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR026137. Leu_rpt_41.
[Graphical view]
PANTHERiPTHR15354. PTHR15354. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q15345-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAPEAWRAR SCWFCEVAAA TTMEATSREA APAKSSASGP NAPPALFELC
60 70 80 90 100
GRAVSAHMGV LESGVWALPG PILQSILPLL NIYYLERIEE TALKKGLSTQ
110 120 130 140 150
AIWRRLWDEL MKTRPSSLES VTCWRAKFME AFFSHVLRGT IDVSSDRRLC
160 170 180 190 200
DQRFSPLLHS SRHVRQLTIC NMLQGATELV AEPNRRVLET LASSLHTLKF
210 220 230 240 250
RHLLFSDVAA QQSLRQLLHQ LIHHGAVSQV SLYSWPVPES ALFILILTMS
260 270 280 290 300
AGFWQPGPGG PPCRLCGEAS RGRAPSRDEG SLLLGSRRPR RDAAERCAAA
310 320 330 340 350
LMASRRKSEA KQMPRAAPAT RVTRRSTQES LTAGGTDLKR ELHPPATSHE
360 370 380 390 400
APGTKRSPSA PAATSSASSS TSSYKRAPAS SAPQPKPLKR FKRAAGKKGA
410 420 430 440 450
RTRQGPGAES EDLYDFVFIV AGEKEDGEEM EIGEVACGAL DGSDPSCLGL
460 470 480 490 500
PALEASQRFR SISTLELFTV PLSTEAALTL CHLLSSWVSL ESLTLSYNGL
510 520 530 540 550
GSNIFRLLDS LRALSGQAGC RLRALHLSDL FSPLPILELT RAIVRALPLL
560 570 580 590 600
RVLSIRVDHP SQRDNPGVPG NAGPPSHIIG DEEIPENCLE QLEMGFPRGA
610 620 630 640 650
QPAPLLCSVL KASGSLQQLS LDSATFASPQ DFGLVLQTLK EYNLALKRLS
660 670 680 690 700
FHDMNLADCQ SEVLFLLQNL TLQEITFSFC RLFEKRPAQF LPEMVAAMKG
710 720 730 740 750
NSTLKGLRLP GNRLGNAGLL ALADVFSEDS SSSLCQLDIS SNCIKPDGLL
760 770 780 790 800
EFAKRLERWG RGAFGHLRLF QNWLDQDAVT AREAIRRLRA TCHVVSDSWD
810
SSQAFADYVS TM
Length:812
Mass (Da):88,650
Last modified:June 26, 2007 - v3
Checksum:i9356F26D014B436A
GO
Isoform 3 (identifier: Q15345-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     716-729: NAGLLALADVFSED → GGQTLGRERGKELG
     730-812: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:729
Mass (Da):79,298
Checksum:i71719DF9D154D87E
GO

Sequence cautioni

The sequence AAQ15266 differs from that shown. Reason: Frameshift at positions 56 and 132.Curated
The sequence AAQ15266 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
Isoform 3 : The sequence BAC86308 differs from that shown. frameshifts in positions 12, 15 and 38, to erroneous initiation (Translation N-terminally extended) and to miscellaneous discrepancy (The N-terminus differs for unknown reasons)Curated
The sequence CAA60013 differs from that shown. Reason: Frameshift at position 799.Curated
The sequence CAD97609 differs from that shown. Reason: Frameshift at positions 132 and 186.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti429E → K in AAQ15266 (PubMed:15498874).Curated1
Sequence conflicti603A → S in BAC86308 (Ref. 7) Curated1
Sequence conflicti654M → I in CAD97609 (PubMed:17974005).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_051117609V → I.2 PublicationsCorresponds to variant rs11542623dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_009234716 – 729NAGLL…VFSED → GGQTLGRERGKELG in isoform 3. 1 PublicationAdd BLAST14
Alternative sequenceiVSP_009235730 – 812Missing in isoform 3. 1 PublicationAdd BLAST83

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125827 mRNA. Translation: BAC86308.1. Sequence problems.
AK291283 mRNA. Translation: BAF83972.1.
AK297596 mRNA. Translation: BAG59981.1.
AL122001, AL121602 Genomic DNA. Translation: CAI21964.1.
AL121602, AL122001 Genomic DNA. Translation: CAI22118.1.
CH471059 Genomic DNA. Translation: EAX06927.1.
BC004953 mRNA. Translation: AAH04953.2.
BC101522 mRNA. Translation: AAI01523.1.
BC101524 mRNA. Translation: AAI01525.1.
BX537366 mRNA. Translation: CAD97609.1. Frameshift.
AF370430 mRNA. Translation: AAQ15266.1. Sequence problems.
X86018 mRNA. Translation: CAA60013.1. Frameshift.
CCDSiCCDS533.1. [Q15345-2]
PIRiS52797.
RefSeqiNP_006360.3. NM_006369.4. [Q15345-2]
UniGeneiHs.144941.

Genome annotation databases

EnsembliENST00000343304; ENSP00000343298; ENSG00000132128. [Q15345-2]
ENST00000617190; ENSP00000477792; ENSG00000132128. [Q15345-2]
GeneIDi10489.
KEGGihsa:10489.
UCSCiuc001cpn.4. human. [Q15345-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK125827 mRNA. Translation: BAC86308.1. Sequence problems.
AK291283 mRNA. Translation: BAF83972.1.
AK297596 mRNA. Translation: BAG59981.1.
AL122001, AL121602 Genomic DNA. Translation: CAI21964.1.
AL121602, AL122001 Genomic DNA. Translation: CAI22118.1.
CH471059 Genomic DNA. Translation: EAX06927.1.
BC004953 mRNA. Translation: AAH04953.2.
BC101522 mRNA. Translation: AAI01523.1.
BC101524 mRNA. Translation: AAI01525.1.
BX537366 mRNA. Translation: CAD97609.1. Frameshift.
AF370430 mRNA. Translation: AAQ15266.1. Sequence problems.
X86018 mRNA. Translation: CAA60013.1. Frameshift.
CCDSiCCDS533.1. [Q15345-2]
PIRiS52797.
RefSeqiNP_006360.3. NM_006369.4. [Q15345-2]
UniGeneiHs.144941.

3D structure databases

ProteinModelPortaliQ15345.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115752. 19 interactors.
IntActiQ15345. 5 interactors.
MINTiMINT-1419045.
STRINGi9606.ENSP00000343298.

PTM databases

iPTMnetiQ15345.
PhosphoSitePlusiQ15345.

Polymorphism and mutation databases

BioMutaiLRRC41.
DMDMi150421588.

Proteomic databases

EPDiQ15345.
PaxDbiQ15345.
PeptideAtlasiQ15345.
PRIDEiQ15345.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343304; ENSP00000343298; ENSG00000132128. [Q15345-2]
ENST00000617190; ENSP00000477792; ENSG00000132128. [Q15345-2]
GeneIDi10489.
KEGGihsa:10489.
UCSCiuc001cpn.4. human. [Q15345-2]

Organism-specific databases

CTDi10489.
GeneCardsiLRRC41.
H-InvDBHIX0000546.
HGNCiHGNC:16917. LRRC41.
HPAiHPA051941.
neXtProtiNX_Q15345.
OpenTargetsiENSG00000132128.
PharmGKBiPA142671529.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHRR. Eukaryota.
ENOG410YFW5. LUCA.
GeneTreeiENSGT00390000015908.
HOGENOMiHOG000013094.
HOVERGENiHBG102701.
InParanoidiQ15345.
KOiK10347.
OMAiFADYISV.
OrthoDBiEOG091G02TR.
PhylomeDBiQ15345.
TreeFamiTF335481.

Enzyme and pathway databases

UniPathwayiUPA00143.
ReactomeiR-HSA-983168. Antigen processing: Ubiquitination & Proteasome degradation.

Miscellaneous databases

ChiTaRSiLRRC41. human.
GeneWikiiLRRC41.
GenomeRNAii10489.
PROiQ15345.

Gene expression databases

BgeeiENSG00000132128.
CleanExiHS_LRRC41.
ExpressionAtlasiQ15345. baseline and differential.
GenevisibleiQ15345. HS.

Family and domain databases

Gene3Di3.80.10.10. 2 hits.
InterProiIPR032675. L_dom-like.
IPR026137. Leu_rpt_41.
[Graphical view]
PANTHERiPTHR15354. PTHR15354. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiLRC41_HUMAN
AccessioniPrimary (citable) accession number: Q15345
Secondary accession number(s): A8K5G8
, Q3MJ96, Q5TDF5, Q71RA8, Q9BSM0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 16, 2004
Last sequence update: June 26, 2007
Last modified: November 30, 2016
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-23 is the initiator.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.