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Q15334

- L2GL1_HUMAN

UniProt

Q15334 - L2GL1_HUMAN

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Protein

Lethal(2) giant larvae protein homolog 1

Gene
LLGL1, DLG4, HUGL, HUGL1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Cortical cytoskeleton protein found in a complex involved in maintaining cell polarity and epithelial integrity. Involved in the regulation of mitotic spindle orientation, proliferation, differentiation and tissue organization of neuroepithelial cells. Involved in axonogenesis through RAB10 activation thereby regulating vesicular membrane trafficking toward the axonal plasma membrane.2 Publications

GO - Molecular functioni

  1. protein binding Source: UniProtKB
  2. protein kinase binding Source: UniProtKB
  3. Rab GTPase activator activity Source: UniProtKB
  4. structural molecule activity Source: ProtInc

GO - Biological processi

  1. axonogenesis Source: UniProtKB
  2. cortical actin cytoskeleton organization Source: UniProtKB
  3. exocytosis Source: UniProtKB-KW
  4. Golgi to plasma membrane transport Source: UniProtKB
  5. maintenance of apical/basal cell polarity Source: Ensembl
  6. positive regulation of Rab GTPase activity Source: GOC
  7. protein complex assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Exocytosis

Names & Taxonomyi

Protein namesi
Recommended name:
Lethal(2) giant larvae protein homolog 1
Short name:
LLGL
Alternative name(s):
DLG4
Hugl-1
Human homolog to the D-lgl gene protein
Gene namesi
Name:LLGL1
Synonyms:DLG4, HUGL, HUGL1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6628. LLGL1.

Subcellular locationi

Early endosome membrane By similarity. Golgi apparatustrans-Golgi network membrane By similarity. Golgi apparatus membrane By similarity. Cell projectionaxon By similarity. Cytoplasmcytoskeleton
Note: Localized to the lateral membrane during the polarization and formation cell-cell contacts. Enriched in developping axons By similarity.2 Publications

GO - Cellular componenti

  1. axon Source: UniProtKB-SubCell
  2. cortical actin cytoskeleton Source: UniProtKB
  3. cytoplasm Source: UniProtKB
  4. cytoskeleton Source: ProtInc
  5. early endosome membrane Source: UniProtKB
  6. Golgi cis cisterna Source: UniProtKB
  7. Golgi membrane Source: UniProtKB-SubCell
  8. myelin sheath abaxonal region Source: Ensembl
  9. trans-Golgi network membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell projection, Cytoplasm, Cytoskeleton, Endosome, Golgi apparatus, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30396.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 10641064Lethal(2) giant larvae protein homolog 1PRO_0000232725Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei663 – 6631Phosphoserine1 Publication
Modified residuei958 – 9581Phosphothreonine By similarity

Post-translational modificationi

Phosphorylated at least at Ser-663 by PRKCI.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15334.
PaxDbiQ15334.
PRIDEiQ15334.

PTM databases

PhosphoSiteiQ15334.

Expressioni

Tissue specificityi

Expressed in brain, kidney, and muscle but is barely seen in heart and placenta. Down-regulated or lost in all cell lines and in most of the tumor samples analyzed. Loss was associated with advanced stage of the disease.3 Publications

Gene expression databases

ArrayExpressiQ15334.
BgeeiQ15334.
CleanExiHS_DLG4.
HS_LLGL1.
GenevestigatoriQ15334.

Organism-specific databases

HPAiHPA022924.
HPA023569.

Interactioni

Subunit structurei

Associated with nonmuscle myosin II heavy chain. Interacts with PRKCI/aPKC, PARD6B/Par-6 and PARD6A. Interacts with STX4A By similarity. Interacts with RAB10 (GDP-bound form); the interaction is direct and promotes RAB10 association with membranes and activation through competition with the Rab inhibitor GDI1 By similarity. Interacts with VPRBP.3 Publications

Protein-protein interaction databases

BioGridi110183. 16 interactions.
IntActiQ15334. 25 interactions.
MINTiMINT-1387867.
STRINGi9606.ENSP00000321537.

Structurei

3D structure databases

ProteinModelPortaliQ15334.
SMRiQ15334. Positions 439-464.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati38 – 7134WD 1Add
BLAST
Repeati78 – 11942WD 2Add
BLAST
Repeati139 – 17638WD 3Add
BLAST
Repeati200 – 23435WD 4Add
BLAST
Repeati240 – 27233WD 5Add
BLAST
Repeati290 – 33243WD 6Add
BLAST
Repeati340 – 37435WD 7Add
BLAST
Repeati396 – 47479WD 8Add
BLAST
Repeati518 – 59376WD 9Add
BLAST
Repeati602 – 66362WD 10Add
BLAST
Repeati723 – 78361WD 11Add
BLAST
Repeati792 – 84453WD 12Add
BLAST
Repeati849 – 90254WD 13Add
BLAST
Repeati916 – 93924WD 14Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat L(2)GL family.
Contains 14 WD repeats.

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiNOG289584.
HOGENOMiHOG000115700.
HOVERGENiHBG052711.
InParanoidiQ15334.
KOiK06094.
OMAiVTLHAEW.
OrthoDBiEOG79W94C.
PhylomeDBiQ15334.
TreeFamiTF314585.

Family and domain databases

Gene3Di2.130.10.10. 3 hits.
InterProiIPR000664. Lethal2_giant.
IPR013577. LLGL2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PfamiPF08366. LLGL. 1 hit.
[Graphical view]
PRINTSiPR00962. LETHAL2GIANT.
SMARTiSM00320. WD40. 5 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 4 hits.
PROSITEiPS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15334-1 [UniParc]FASTAAdd to Basket

« Hide

MMKFRFRRQG ADPQREKLKQ ELFAFNKTVE HGFPNQPSAL AFDPELRIMA     50
IGTRSGAVKI YGAPGVEFTG LHRDAATVTQ MHFLTGQGRL LSLLDDSSLH 100
LWEIVHHNGC AHLEEALSFQ LPSRPGFDGA SAPLSLTRVT VVLLVAASDI 150
AALGTEGSSV FFLDVTTLTL LEGQTLAPGE VLRSVPDDYR CGKALGPVES 200
LQGHLRDPTK ILIGYSRGLL VIWNQASQCV DHIFLGNQQL ESLCWGRDSS 250
TVVSSHSDGS YAVWSVDAGS FPTLQPTVAT TPYGPFPCKA INKILWRNCE 300
SGGHFIIFSG GMPRASYGDR HCVSVLRAET LVTLDFTSRI IDFFTVHSTR 350
PEDEFDDPQA LAVLLEEELV VLDLQTPGWP AVPAPYLAPL HSSAITCSAH 400
VASVPAKLWA RIVSAGEQQS PQPVSSALSW PITGGRNLAQ EPSQRGLLLT 450
GHEDGTVRFW DASGVALRPL YKLSTAGLFQ TDCEHADSLA QAAEDDWPPF 500
RKVGCFDPYS DDPRLGVQKV ALCKYTAQMV VAGTAGQVLV LELSDVPVEQ 550
AVSVAIIDLL QDREGFTWKG HERLSPRTGP LPWPAGFQPR VLVQCLPPAA 600
VTAVTLHTEW SLVAFGTSHG FGLFDYQRKS PVLARCTLHP NDSLAMEGPL 650
SRVKSLKKSL RQSFRRIRKS RVSGKKRAAN ASSKLQEANA QLAEQACPHD 700
VEMTPVQRRI EPRSADDSLS GVVRCLYFAD TFLRDGAHHG PTMWAGTNSG 750
SVFAYALEVP AAAVGGEKRP EQAVEAVLGK EVQLMHRAPV VAIAVLDGRG 800
RPLPEPYEAS RDLAQAPDMQ GGHAVLIASE EQFKVFTLPK VSAKTKFKLT 850
AHEGCRVRKV ALATFASVAC EDYAETCLAC LTNLGDVHVF SVPGLRPQVH 900
YSCIRKEDIS GIASCVFTRH GQGFYLISPS EFERFSLSAR NITEPLCSLD 950
INWPRDATQA SYRIRESPKL SQANGTPSIL LAPQSLDGSP DPAHSMGPDT 1000
PEPPEAALSP MSIDSATSAD TTLDTTGDVT VEDVKDFLGS SEESEKNLRN 1050
LAEDEAHACA ILIK 1064
Length:1,064
Mass (Da):115,418
Last modified:September 22, 2009 - v3
Checksum:i9318D6736934E4D5
GO

Sequence cautioni

The sequence BAA19516.1 differs from that shown. Reason: Frameshift at positions 205, 216, 737, 740, 794, 799, 866, 872, 881, 945, 968 and 1024.

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti148 – 1481S → G.3 Publications
Corresponds to variant rs2290505 [ dbSNP | Ensembl ].
VAR_058710
Natural varianti550 – 5501Q → H.1 Publication
Corresponds to variant rs1063683 [ dbSNP | Ensembl ].
VAR_058711

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti5 – 51R → P in CAA60130. 1 Publication
Sequence conflicti152 – 1521A → G in BAA19516. 1 Publication
Sequence conflicti159 – 1591S → SS in CAA60130. 1 Publication
Sequence conflicti194 – 1941A → D in CAA60130. 1 Publication
Sequence conflicti206 – 2061R → Q in CAA60130. 1 Publication
Sequence conflicti216 – 2161S → D in BAA19516. 1 Publication
Sequence conflicti223 – 2231W → R in CAA60130. 1 Publication
Sequence conflicti226 – 2272AS → SR in BAA19516. 1 Publication
Sequence conflicti337 – 3382TS → HF in CAA60130. 1 Publication
Sequence conflicti400 – 4001H → Y in BAA19516. 1 Publication
Sequence conflicti486 – 4861A → S in CAA60130. 1 Publication
Sequence conflicti580 – 5801P → L in CAA60130. 1 Publication
Sequence conflicti588 – 5881Q → L in BAA19516. 1 Publication
Sequence conflicti590 – 5901R → C in CAA60130. 1 Publication
Sequence conflicti624 – 6296FDYQRK → L in CAA60130. 1 Publication
Sequence conflicti686 – 6861Q → L in BAA19516. 1 Publication
Sequence conflicti781 – 7822EV → KE in BAA19516. 1 Publication
Sequence conflicti782 – 7821V → L in CAA60130. 1 Publication
Sequence conflicti799 – 7991Missing in CAA60130. 1 Publication
Sequence conflicti818 – 8181D → H in CAA60130. 1 Publication
Sequence conflicti860 – 8601V → VV in CAA60130. 1 Publication
Sequence conflicti871 – 8711E → R in BAA19516. 1 Publication
Sequence conflicti894 – 8941Missing in BAA19516. 1 Publication
Sequence conflicti898 – 8981Q → E in CAA60130. 1 Publication
Sequence conflicti945 – 9451P → G in CAA60130. 1 Publication
Sequence conflicti1060 – 10645AILIK → CI in CAA60130. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86371 mRNA. Translation: CAA60130.1.
D50550 mRNA. Translation: BAA19516.1. Frameshift.
BC028037 mRNA. Translation: AAH28037.1.
BC151838 mRNA. Translation: AAI51839.1.
CCDSiCCDS32586.1.
PIRiI38171.
RefSeqiNP_004131.3. NM_004140.3.
UniGeneiHs.513983.

Genome annotation databases

EnsembliENST00000316843; ENSP00000321537; ENSG00000131899.
GeneIDi3996.
KEGGihsa:3996.
UCSCiuc002gsp.3. human.

Polymorphism databases

DMDMi259016343.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86371 mRNA. Translation: CAA60130.1 .
D50550 mRNA. Translation: BAA19516.1 . Frameshift.
BC028037 mRNA. Translation: AAH28037.1 .
BC151838 mRNA. Translation: AAI51839.1 .
CCDSi CCDS32586.1.
PIRi I38171.
RefSeqi NP_004131.3. NM_004140.3.
UniGenei Hs.513983.

3D structure databases

ProteinModelPortali Q15334.
SMRi Q15334. Positions 439-464.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110183. 16 interactions.
IntActi Q15334. 25 interactions.
MINTi MINT-1387867.
STRINGi 9606.ENSP00000321537.

PTM databases

PhosphoSitei Q15334.

Polymorphism databases

DMDMi 259016343.

Proteomic databases

MaxQBi Q15334.
PaxDbi Q15334.
PRIDEi Q15334.

Protocols and materials databases

DNASUi 3996.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000316843 ; ENSP00000321537 ; ENSG00000131899 .
GeneIDi 3996.
KEGGi hsa:3996.
UCSCi uc002gsp.3. human.

Organism-specific databases

CTDi 3996.
GeneCardsi GC17P018128.
HGNCi HGNC:6628. LLGL1.
HPAi HPA022924.
HPA023569.
MIMi 600966. gene.
neXtProti NX_Q15334.
PharmGKBi PA30396.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG289584.
HOGENOMi HOG000115700.
HOVERGENi HBG052711.
InParanoidi Q15334.
KOi K06094.
OMAi VTLHAEW.
OrthoDBi EOG79W94C.
PhylomeDBi Q15334.
TreeFami TF314585.

Miscellaneous databases

GeneWikii LLGL1.
GenomeRNAii 3996.
NextBioi 15682.
PROi Q15334.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15334.
Bgeei Q15334.
CleanExi HS_DLG4.
HS_LLGL1.
Genevestigatori Q15334.

Family and domain databases

Gene3Di 2.130.10.10. 3 hits.
InterProi IPR000664. Lethal2_giant.
IPR013577. LLGL2.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view ]
Pfami PF08366. LLGL. 1 hit.
[Graphical view ]
PRINTSi PR00962. LETHAL2GIANT.
SMARTi SM00320. WD40. 5 hits.
[Graphical view ]
SUPFAMi SSF50978. SSF50978. 4 hits.
PROSITEi PS00678. WD_REPEATS_1. 2 hits.
PS50082. WD_REPEATS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "A human homologue of the Drosophila tumour suppressor gene l(2)gl maps to 17p11.2-12 and codes for a cytoskeletal protein that associates with nonmuscle myosin II heavy chain."
    Strand D.J., Unger S., Corvi R., Hartenstein K., Schenkel H., Kalmes A., Merdes G., Neumann B., Kreig-Schneider F., Coy J.F., Poustka A., Schwab M., Mechler B.
    Oncogene 11:291-301(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITH MYOSIN II HEAVY CHAIN, VARIANTS GLY-148 AND HIS-550.
    Tissue: Brain.
  2. "The human homologue of the murine Llglh gene (LLGL) maps within the Smith-Magenis syndrome region in 17p11.2."
    Koyama K., Fukushima Y., Inazawa J., Tomotsune D., Takahashi N., Nakamura Y.
    Cytogenet. Cell Genet. 72:78-82(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT GLY-148.
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT GLY-148.
    Tissue: Fetal brain.
  4. "Mammalian Lgl forms a protein complex with PAR-6 and aPKC independently of PAR-3 to regulate epithelial cell polarity."
    Yamanaka T., Horikoshi Y., Sugiyama Y., Ishiyama C., Suzuki A., Hirose T., Iwamatsu A., Shinohara A., Ohno S.
    Curr. Biol. 13:734-743(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PARD6B/PAR-6 AND PRKCI/APKC, SUBCELLULAR LOCATION, PHOSPHORYLATION AT SER-663.
  5. "Reduced expression of Hugl-1, the human homologue of Drosophila tumour suppressor gene lgl, contributes to progression of colorectal cancer."
    Schimanski C.C., Schmitz G., Kashyap A., Bosserhoff A.K., Bataille F., Schafer S.C., Lehr H.A., Berger M.R., Galle P.R., Strand S., Strand D.
    Oncogene 24:3100-3109(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. Cited for: FUNCTION, TISSUE SPECIFICITY, INVOLVEMENT IN COLORECTAL CANCER AND MELANOMA.
  7. Cited for: INTERACTION WITH VPRBP.
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiL2GL1_HUMAN
AccessioniPrimary (citable) accession number: Q15334
Secondary accession number(s): A7MBM7
, O00188, Q58F11, Q86UK6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 18, 2006
Last sequence update: September 22, 2009
Last modified: July 9, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Down-regulation of LLGL1 is associated with the progression of colorectal cancer and melanoma. Located within the Smith-Magenis syndrome region on chromosome 17; deleted in patients with this syndrome.
Expression increases cell adhesion and decreases cell migration. Substitutes for Drosophila l2gl tumor suppressor function in vivo.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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