Q15326 (ZMY11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Zinc finger MYND domain-containing protein 11

Alternative name(s):
Adenovirus 5 E1A-binding protein
Protein BS69

Gene names

Name:	ZMYND11
Synonyms:	BS69

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	562 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Corepressor of transcription Probable. Ref.4
Subunit structure	Interacts (via MYND-type zinc finger) with NCOR1. Interacts (via MYND-type zinc finger) with human adenovirus early E1A protein (via PXLXP motif); this interaction inhibits E1A mediated transactivation. Interacts (via MYND-type zinc finger) with Epstein-Barr virus EBNA2 protein (via PXLXP motif). Ref.4 Ref.5
Subcellular location	Nucleus.
Post-translational modification	Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.6 Ref.7
Sequence similarities	Contains 1 bromo domain. Contains 1 MYND-type zinc finger. Contains 1 PHD-type zinc finger. Contains 1 PWWP domain.

Ontologies

Keywords
Biological process	Cell cycle Host-virus interaction Transcription Transcription regulation
Cellular component	Nucleus
Domain	Bromodomain Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Repressor
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell proliferation Traceable author statement. Source: ProtInc interspecies interaction between organisms Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of I-kappaB kinase/NF-kappaB cascade Inferred from mutant phenotype. Source: UniProtKB negative regulation of JNK cascade Inferred from mutant phenotype. Source: UniProtKB negative regulation of apoptotic process Inferred from mutant phenotype. Source: UniProtKB negative regulation of transcription from RNA polymerase II promoter Traceable author statement. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from direct assay. Source: HPA nucleus Inferred from direct assay. Source: HPA
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
LTBR	P36941	5	EBI-2799565,EBI-3509981

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 562	562	Zinc finger MYND domain-containing protein 11		PRO_0000211218
Regions
	Domain	128 – 198	71	Bromo
	Domain	240 – 291	52	PWWP
	Zinc finger	60 – 108	49	PHD-type
	Zinc finger	523 – 558	36	MYND-type
	Region	412 – 532	121	Interaction with human adenovirus E1A
	Motif	354 – 360	7	Nuclear localization signal Potential
Amino acid modifications
	Modified residue	381	1	Phosphoserine Ref.6 Ref.7

Sequences

	Sequence		Length	Mass (Da)
	Q15326 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: E4280C54505B0894	FASTA	562	66,203
	10 20 30 40 50 60 MSRVHGMHPK ETTRQLSLAV KDGLIVETLT VGCKGSKAGI EQEGYWLPGD EIDWETENHD 70 80 90 100 110 120 WYCFECHLPG EVLICDLCFR VYHSKCLSDE FRLRDSSSPW QCPVCRSIKK KNTNKQEMGT 130 140 150 160 170 180 YLRFIVSRMK ERAIDLNKKG KDNKHPMYRR LVHSAVDVPT IQEKVNEGKY RSYEEFKADA 190 200 210 220 230 240 QLLLHNTVIF YGADSEQADI ARMLYKDTCH ELDELQLCKN CFYLSNARPD NWFCYPCIPN 250 260 270 280 290 300 HELVWAKMKG FGFWPAKVMQ KEDNQVDVRF FGHHHQRAWI PSENIQDITV NIHRLHVKRS 310 320 330 340 350 360 MGWKKACDEL ELHQRFLREG RFWKSKNEDR GEEEAESSIS STSNEQLKVT QEPRAKKGRR 370 380 390 400 410 420 NQSVEPKKEE PEPETEAVSS SQEIPTMPQP IEKVSVSTQT KKLSASSPRM LHRSTQTTND 430 440 450 460 470 480 GVCQSMCHDK YTKIFNDFKD RMKSDHKRET ERVVREALEK LRSEMEEEKR QAVNKAVANM 490 500 510 520 530 540 QGEMDRKCKQ VKEKCKEEFV EEIKKLATQH KQLISQTKKK QWCYNCEEEA MYHCCWNTSY 550 560 CSIKCQQEHW HAEHKRTCRR KR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"BS69, a novel adenovirus E1A-associated protein that inhibits E1A transactivation." Hateboer G., Gennissen A., Ramos Y.F.M., Kerkhoven R.M., Sonntag-Buck V., Stunnenberg H.G., Bernards R. EMBO J. 14:3159-3169(1995) [PubMed: 7621829] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Colon carcinoma.
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[3]	"The DNA sequence and comparative analysis of human chromosome 10." Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L., Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K., Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L., Taylor A., Battles J. , Bird C.P., Ainscough R., Almeida J.P., Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P., Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N., Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A., Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C., Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D., Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C., Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K., Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A., Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S., McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S., Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V., Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A., Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M., Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A., Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P., Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y., Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D., Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J. Nature 429:375-381(2004) [PubMed: 15164054] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR." Masselink H., Bernards R. Oncogene 19:1538-1546(2000) [PubMed: 10734313] [Abstract] Cited for: FUNCTION, INTERACTION WITH NCOR1.
[5]	"The conserved Mynd domain of BS69 binds cellular and oncoviral proteins through a common PXLXP motif." Ansieau S., Leutz A. J. Biol. Chem. 277:4906-4910(2002) [PubMed: 11733528] [Abstract] Cited for: INTERACTION WITH HUMAN ADENOVIRUS EARLY E1A PROTEIN, INTERACTION WITH EPSTEIN-BARR VIRUS EBNA2 PROTEIN.
[6]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[7]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-381, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X86098 mRNA. Translation: CAA60052.1. AK312570 mRNA. Translation: BAG35465.1. AL589988, AL603831 Genomic DNA. Translation: CAH69845.1. AL603831, AL589988 Genomic DNA. Translation: CAI40899.1.
IPI	IPI00873394.
PIR	S56145.
RefSeq	NP_006615.2. NM_006624.5.
UniGene	Hs.292265.
3D structure databases
ProteinModelPortal	Q15326.
SMR	Q15326. Positions 57-216, 239-315, 523-559.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15326. 6 interactions.
MINT	MINT-156360.
STRING	Q15326.
PTM databases
PhosphoSite	Q15326.
Polymorphism databases
DMDM	10719919.
Proteomic databases
PRIDE	Q15326.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000309776; ENSP00000309992; ENSG00000015171. ENST00000381584; ENSP00000370996; ENSG00000015171. ENST00000381591; ENSP00000371003; ENSG00000015171. ENST00000397962; ENSP00000381053; ENSG00000015171.
GeneID	10771.
KEGG	hsa:10771.
UCSC	uc001ifl.1. human.
Organism-specific databases
CTD	10771.
GeneCards	GC10P000170.
H-InvDB	HIX0025946.
HGNC	HGNC:16966. ZMYND11.
HPA	HPA015816. HPA030553.
MIM	608668. gene.
neXtProt	NX_Q15326.
PharmGKB	PA128394578.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG14425.
HOVERGEN	HBG054949.
InParanoid	Q15326.
PhylomeDB	Q15326.
Gene expression databases
ArrayExpress	Q15326.
Bgee	Q15326.
CleanEx	HS_ZMYND11.
Genevestigator	Q15326.
GermOnline	ENSG00000015171. Homo sapiens.
Family and domain databases
InterPro	IPR001487. Bromodomain. IPR000313. PWWP. IPR019786. Zinc_finger_PHD-type_CS. IPR011011. Znf_FYVE_PHD. IPR002893. Znf_MYND. IPR001965. Znf_PHD. IPR019787. Znf_PHD-finger. IPR001841. Znf_RING. IPR013083. Znf_RING/FYVE/PHD. [Graphical view]
Gene3D	G3DSA:1.20.920.10. Bromodomain. 1 hit. G3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 1 hit.
Pfam	PF00439. Bromodomain. 1 hit. PF00855. PWWP. 1 hit. [Graphical view]
SMART	SM00297. BROMO. 1 hit. SM00249. PHD. 1 hit. SM00293. PWWP. 1 hit. SM00184. RING. 1 hit. [Graphical view]
SUPFAM	SSF47370. Bromodomain. 1 hit. SSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITE	PS50014. BROMODOMAIN_2. 1 hit. PS50812. PWWP. 1 hit. PS01360. ZF_MYND_1. 1 hit. PS50865. ZF_MYND_2. 1 hit. PS01359. ZF_PHD_1. 1 hit. PS50016. ZF_PHD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	40897.
SOURCE	Search...

Entry information

Entry name

ZMY11_HUMAN

Accession

Primary (citable) accession number: Q15326
Secondary accession number(s): B2R6G8, Q5VUI1

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 1, 2000
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 104 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.