Reviewed, UniProtKB/Swiss-Prot Q15323 (K1H1_HUMAN)

Names and origin

Protein names

Recommended name:
    Keratin, type I cuticular Ha1
Alternative name(s):
    Hair keratin, type I Ha1
    Keratin-31
      Short name=K31

Gene names

Name:	KRT31
Synonyms:	HHA1, HKA1, KRTHA1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	416 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Tissue specificity	Present in scalp but not in hairless skin. Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla. Ref.3 Ref.6
Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	epidermis development Ref.1 Traceable author statement. Source: ProtInc
Cellular component	intermediate filament Traceable author statement. Source: ProtInc
Molecular function	protein binding Inferred from physical interaction. Source: IntAct structural constituent of cytoskeleton Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
BAK1	Q16611	1	EBI-948001,EBI-519866
CDC20	Q12834	1	EBI-948001,EBI-367462
CDC25B	P30305	1	EBI-948001,EBI-1051746
DGKB	Q9Y6T7	1	EBI-948001,EBI-1049421
DLG3	Q92796	1	EBI-948001,EBI-80440
DNPEP	Q9ULA0	1	EBI-948001,EBI-748356
ELF3	P78545	1	EBI-948001,EBI-1057285
LYAR	Q9NX58	1	EBI-948001,EBI-713507
PLEKHB2	Q96CS7	1	EBI-948001,EBI-373552
STK38L	Q9Y2H1	1	EBI-948001,EBI-991501
TWF2	Q6IBS0	1	EBI-948001,EBI-722204
YWHAG	P61981	1	EBI-948001,EBI-359832

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 416	416	Keratin, type I cuticular Ha1		PRO_0000063684
Regions
	Region	1 – 56	56	Head
	Region	57 – 363	307	Rod
	Region	57 – 91	35	Coil 1A
	Region	92 – 102	11	Linker 1
	Region	103 – 203	101	Coil 1B
	Region	204 – 219	16	Linker 12
	Region	220 – 363	144	Coil 2
	Region	364 – 416	53	Tail
Sites
	Site	305	1	Stutter
Natural variations
	Natural variant	39	1	A → G: dbSNP rs6503628.		VAR_046989
	Natural variant	82	1	A → V: dbSNP rs6503627.		VAR_046990
	Natural variant	377	1	A → V: dbSNP rs34293483.		VAR_046991
Experimental info
	Sequence conflict	153 – 154	2	QL → HV in CAA60378. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q15323-1 [UniParc]. Last modified October 14, 2008. Version 3. Checksum: C284DD33A4896009	FASTA	416	47,237
	10 20 30 40 50 60 MPYNFCLPSL SCRTSCSSRP CVPPSCHSCT LPGACNIPAN VSNCNWFCEG SFNGSEKETM 70 80 90 100 110 120 QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC PSYQSYFKTI EELQQKILCT 130 140 150 160 170 180 KSENARLVVQ IDNAKLAADD FRTKYQTELS LRQLVESDIN GLRRILDELT LCKSDLEAQV 190 200 210 220 230 240 ESLKEELLCL KSNHEQEVNT LRCQLGDRLN VEVDAAPTVD LNRVLNETRS QYEALVETNR 250 260 270 280 290 300 REVEQWFTTQ TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL 310 320 330 340 350 360 TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE CEINTYRSLL 370 380 390 400 410 ESEDCNLPSN PCATTNACSK PIGPCLSNPC TSCVPPAPCT PCAPRPRCGP CNSFVR

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A cDNA encoding the human type I hair keratin hHal." Fink P., Rogers M.A., Krieg T., Winter H., Schweizer J. Biochim. Biophys. Acta 1264:12-14(1995) [PubMed: 7578244] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Hair.
[2]	Rogers M.A. Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[6]	"Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle." Bowden P.E., Hainey S.D., Parker G., Jones D.O., Zimonjic D., Popescu N., Hodgins M.B. J. Invest. Dermatol. 110:158-164(1998) [PubMed: 9457912] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X86570 mRNA. Translation: CAA60378.1. Y16787 Genomic DNA. Translation: CAA76383.1. CH471152 Genomic DNA. Translation: EAW60730.1. BC114468 mRNA. Translation: AAI14469.1.
IPI	IPI00032513.
PIR	S60034.
RefSeq	NP_002268.2.
UniGene	Hs.41696
3D structure databases
HSSP	HSSP built from PDB template 1GK7 based on UniProtKB P08670.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15323. 17 interactions.
PTM databases
PhosphoSite	Q15323.
Proteomic databases
PRIDE	Q15323.
Genome annotation databases
Ensembl	ENSG00000094796. Homo sapiens. [Contig view]
GeneID	3881.
KEGG	hsa:3881.
Organism-specific databases
GeneCards	GC17M036804.
H-InvDB	HIX0039252.
HGNC	HGNC:6448. KRT31.
MIM	601077. gene.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q15323.
HOVERGEN	Q15323.
Gene expression databases
ArrayExpress	Q15323.
Bgee	Q15323.
CleanEx	HS_KRT31.
GermOnline	ENSG00000094796. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. IF. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	15235.
SOURCE	Search...

Entry information

Entry name

K1H1_HUMAN

Accession

Primary (citable) accession number: Q15323
Secondary accession number(s): Q9UE12

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	October 14, 2008
Last modified:	July 7, 2009
This is version 68 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)