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Q15323

- K1H1_HUMAN

UniProt

Q15323 - K1H1_HUMAN

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Protein
Keratin, type I cuticular Ha1
Gene
KRT31, HHA1, HKA1, KRTHA1
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei305 – 3051Stutter

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  1. epidermis development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha1
Alternative name(s):
Hair keratin, type I Ha1
Keratin-31
Short name:
K31
Gene namesi
Name:KRT31
Synonyms:HHA1, HKA1, KRTHA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6448. KRT31.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. intermediate filament Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Keratin, type I cuticular Ha1
PRO_0000063684Add
BLAST

Proteomic databases

MaxQBiQ15323.
PaxDbiQ15323.
PRIDEiQ15323.

PTM databases

PhosphoSiteiQ15323.

Expressioni

Tissue specificityi

Present in scalp but not in hairless skin. Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla.2 Publications

Gene expression databases

ArrayExpressiQ15323.
BgeeiQ15323.
CleanExiHS_KRT31.
GenevestigatoriQ15323.

Organism-specific databases

HPAiHPA049550.

Interactioni

Protein-protein interaction databases

BioGridi110079. 18 interactions.
IntActiQ15323. 9 interactions.
MINTiMINT-2860287.
STRINGi9606.ENSP00000251645.

Structurei

3D structure databases

ProteinModelPortaliQ15323.
SMRiQ15323. Positions 106-204, 274-361.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656Head
Add
BLAST
Regioni57 – 363307Rod
Add
BLAST
Regioni57 – 9135Coil 1A
Add
BLAST
Regioni92 – 10211Linker 1
Add
BLAST
Regioni103 – 203101Coil 1B
Add
BLAST
Regioni204 – 21916Linker 12
Add
BLAST
Regioni220 – 363144Coil 2
Add
BLAST
Regioni364 – 41653Tail
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG321598.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ15323.
KOiK07604.
OMAiTKYHTEL.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ15323.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15323-1 [UniParc]FASTAAdd to Basket

« Hide

MPYNFCLPSL SCRTSCSSRP CVPPSCHSCT LPGACNIPAN VSNCNWFCEG    50
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC 100
PSYQSYFKTI EELQQKILCT KSENARLVVQ IDNAKLAADD FRTKYQTELS 150
LRQLVESDIN GLRRILDELT LCKSDLEAQV ESLKEELLCL KSNHEQEVNT 200
LRCQLGDRLN VEVDAAPTVD LNRVLNETRS QYEALVETNR REVEQWFTTQ 250
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL 300
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE 350
CEINTYRSLL ESEDCNLPSN PCATTNACSK PIGPCLSNPC TSCVPPAPCT 400
PCAPRPRCGP CNSFVR 416
Length:416
Mass (Da):47,237
Last modified:October 14, 2008 - v3
Checksum:iC284DD33A4896009
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391A → G.
Corresponds to variant rs6503628 [ dbSNP | Ensembl ].
VAR_046989
Natural varianti82 – 821A → V.
Corresponds to variant rs6503627 [ dbSNP | Ensembl ].
VAR_046990
Natural varianti377 – 3771A → V.
Corresponds to variant rs34293483 [ dbSNP | Ensembl ].
VAR_046991

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1542QL → HV in CAA60378. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86570 mRNA. Translation: CAA60378.1.
Y16787 Genomic DNA. Translation: CAA76383.1.
CH471152 Genomic DNA. Translation: EAW60730.1.
BC114468 mRNA. Translation: AAI14469.1.
CCDSiCCDS11391.1.
PIRiS60034.
RefSeqiNP_002268.2. NM_002277.2.
UniGeneiHs.41696.

Genome annotation databases

EnsembliENST00000251645; ENSP00000251645; ENSG00000094796.
ENST00000573281; ENSP00000460739; ENSG00000262993.
GeneIDi3881.
KEGGihsa:3881.
UCSCiuc002hwn.3. human.

Polymorphism databases

DMDMi209572740.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X86570 mRNA. Translation: CAA60378.1 .
Y16787 Genomic DNA. Translation: CAA76383.1 .
CH471152 Genomic DNA. Translation: EAW60730.1 .
BC114468 mRNA. Translation: AAI14469.1 .
CCDSi CCDS11391.1.
PIRi S60034.
RefSeqi NP_002268.2. NM_002277.2.
UniGenei Hs.41696.

3D structure databases

ProteinModelPortali Q15323.
SMRi Q15323. Positions 106-204, 274-361.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110079. 18 interactions.
IntActi Q15323. 9 interactions.
MINTi MINT-2860287.
STRINGi 9606.ENSP00000251645.

PTM databases

PhosphoSitei Q15323.

Polymorphism databases

DMDMi 209572740.

Proteomic databases

MaxQBi Q15323.
PaxDbi Q15323.
PRIDEi Q15323.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000251645 ; ENSP00000251645 ; ENSG00000094796 .
ENST00000573281 ; ENSP00000460739 ; ENSG00000262993 .
GeneIDi 3881.
KEGGi hsa:3881.
UCSCi uc002hwn.3. human.

Organism-specific databases

CTDi 3881.
GeneCardsi GC17M039549.
H-InvDB HIX0039252.
HGNCi HGNC:6448. KRT31.
HPAi HPA049550.
MIMi 601077. gene.
neXtProti NX_Q15323.
PharmGKBi PA30237.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG321598.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi Q15323.
KOi K07604.
OMAi TKYHTEL.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q15323.
TreeFami TF332742.

Miscellaneous databases

GeneWikii KRT31.
GenomeRNAii 3881.
NextBioi 15235.
PROi Q15323.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15323.
Bgeei Q15323.
CleanExi HS_KRT31.
Genevestigatori Q15323.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair.
  2. Rogers M.A.
    Submitted (MAR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle."
    Bowden P.E., Hainey S.D., Parker G., Jones D.O., Zimonjic D., Popescu N., Hodgins M.B.
    J. Invest. Dermatol. 110:158-164(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiK1H1_HUMAN
AccessioniPrimary (citable) accession number: Q15323
Secondary accession number(s): Q9UE12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: July 9, 2014
This is version 112 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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