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Protein

Keratin, type I cuticular Ha1

Gene

KRT31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei305 – 3051Stutter

GO - Molecular functioni

  1. structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  1. epidermis development Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha1
Alternative name(s):
Hair keratin, type I Ha1
Keratin-31
Short name:
K31
Gene namesi
Name:KRT31
Synonyms:HHA1, HKA1, KRTHA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componentsi: Chromosome 17, Unplaced

Organism-specific databases

HGNCiHGNC:6448. KRT31.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProtKB
  3. intermediate filament Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30237.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 416416Keratin, type I cuticular Ha1PRO_0000063684Add
BLAST

Proteomic databases

MaxQBiQ15323.
PaxDbiQ15323.
PRIDEiQ15323.

PTM databases

PhosphoSiteiQ15323.

Expressioni

Tissue specificityi

Present in scalp but not in hairless skin. Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla.2 Publications

Gene expression databases

BgeeiQ15323.
CleanExiHS_KRT31.
ExpressionAtlasiQ15323. baseline and differential.
GenevestigatoriQ15323.

Organism-specific databases

HPAiHPA049550.
HPA055194.

Interactioni

Protein-protein interaction databases

BioGridi110079. 198 interactions.
IntActiQ15323. 9 interactions.
MINTiMINT-2860287.
STRINGi9606.ENSP00000251645.

Structurei

3D structure databases

ProteinModelPortaliQ15323.
SMRiQ15323. Positions 54-204, 220-361.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 5656HeadAdd
BLAST
Regioni57 – 363307RodAdd
BLAST
Regioni57 – 9135Coil 1AAdd
BLAST
Regioni92 – 10211Linker 1Add
BLAST
Regioni103 – 203101Coil 1BAdd
BLAST
Regioni204 – 21916Linker 12Add
BLAST
Regioni220 – 363144Coil 2Add
BLAST
Regioni364 – 41653TailAdd
BLAST

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG321598.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ15323.
KOiK07604.
OMAiITSPCTM.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ15323.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNFCLPSL SCRTSCSSRP CVPPSCHSCT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC
110 120 130 140 150
PSYQSYFKTI EELQQKILCT KSENARLVVQ IDNAKLAADD FRTKYQTELS
160 170 180 190 200
LRQLVESDIN GLRRILDELT LCKSDLEAQV ESLKEELLCL KSNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRS QYEALVETNR REVEQWFTTQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCNLPSN PCATTNACSK PIGPCLSNPC TSCVPPAPCT
410
PCAPRPRCGP CNSFVR
Length:416
Mass (Da):47,237
Last modified:October 14, 2008 - v3
Checksum:iC284DD33A4896009
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti153 – 1542QL → HV in CAA60378 (PubMed:7578244).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti39 – 391A → G.
Corresponds to variant rs6503628 [ dbSNP | Ensembl ].
VAR_046989
Natural varianti82 – 821A → V.
Corresponds to variant rs6503627 [ dbSNP | Ensembl ].
VAR_046990
Natural varianti377 – 3771A → V.
Corresponds to variant rs34293483 [ dbSNP | Ensembl ].
VAR_046991

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86570 mRNA. Translation: CAA60378.1.
Y16787 Genomic DNA. Translation: CAA76383.1.
CH471152 Genomic DNA. Translation: EAW60730.1.
BC114468 mRNA. Translation: AAI14469.1.
CCDSiCCDS11391.1.
PIRiS60034.
RefSeqiNP_002268.2. NM_002277.2.
UniGeneiHs.41696.

Genome annotation databases

EnsembliENST00000251645; ENSP00000251645; ENSG00000094796.
ENST00000573281; ENSP00000460739; ENSG00000262993.
GeneIDi3881.
KEGGihsa:3881.
UCSCiuc002hwn.3. human.

Polymorphism databases

DMDMi209572740.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86570 mRNA. Translation: CAA60378.1.
Y16787 Genomic DNA. Translation: CAA76383.1.
CH471152 Genomic DNA. Translation: EAW60730.1.
BC114468 mRNA. Translation: AAI14469.1.
CCDSiCCDS11391.1.
PIRiS60034.
RefSeqiNP_002268.2. NM_002277.2.
UniGeneiHs.41696.

3D structure databases

ProteinModelPortaliQ15323.
SMRiQ15323. Positions 54-204, 220-361.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110079. 198 interactions.
IntActiQ15323. 9 interactions.
MINTiMINT-2860287.
STRINGi9606.ENSP00000251645.

PTM databases

PhosphoSiteiQ15323.

Polymorphism databases

DMDMi209572740.

Proteomic databases

MaxQBiQ15323.
PaxDbiQ15323.
PRIDEiQ15323.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251645; ENSP00000251645; ENSG00000094796.
ENST00000573281; ENSP00000460739; ENSG00000262993.
GeneIDi3881.
KEGGihsa:3881.
UCSCiuc002hwn.3. human.

Organism-specific databases

CTDi3881.
GeneCardsiGC17M039549.
H-InvDBHIX0039252.
HGNCiHGNC:6448. KRT31.
HPAiHPA049550.
HPA055194.
MIMi601077. gene.
neXtProtiNX_Q15323.
PharmGKBiPA30237.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG321598.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ15323.
KOiK07604.
OMAiITSPCTM.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ15323.
TreeFamiTF332742.

Miscellaneous databases

GeneWikiiKRT31.
GenomeRNAii3881.
NextBioi15235.
PROiQ15323.
SOURCEiSearch...

Gene expression databases

BgeeiQ15323.
CleanExiHS_KRT31.
ExpressionAtlasiQ15323. baseline and differential.
GenevestigatoriQ15323.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Hair.
  2. Rogers M.A.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "Characterization and chromosomal localization of human hair-specific keratin genes and comparative expression during the hair growth cycle."
    Bowden P.E., Hainey S.D., Parker G., Jones D.O., Zimonjic D., Popescu N., Hodgins M.B.
    J. Invest. Dermatol. 110:158-164(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.

Entry informationi

Entry nameiK1H1_HUMAN
AccessioniPrimary (citable) accession number: Q15323
Secondary accession number(s): Q9UE12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: April 1, 2015
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.