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Protein

Keratin, type I cuticular Ha1

Gene

KRT31

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei305Stutter1

GO - Molecular functioni

  • structural constituent of cytoskeleton Source: ProtInc

GO - Biological processi

  • epidermis development Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000094796-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha1
Alternative name(s):
Hair keratin, type I Ha1
Keratin-31
Short name:
K31
Gene namesi
Name:KRT31
Synonyms:HHA1, HKA1, KRTHA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6448. KRT31.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • intermediate filament Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi3881.
OpenTargetsiENSG00000094796.
ENSG00000262993.
PharmGKBiPA30237.

Polymorphism and mutation databases

BioMutaiKRT31.
DMDMi209572740.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636841 – 416Keratin, type I cuticular Ha1Add BLAST416

Proteomic databases

PaxDbiQ15323.
PeptideAtlasiQ15323.
PRIDEiQ15323.

PTM databases

iPTMnetiQ15323.
PhosphoSitePlusiQ15323.
SwissPalmiQ15323.

Expressioni

Tissue specificityi

Present in scalp but not in hairless skin. Abundantly expressed in the differentiating cortex of growing (anagen) hair. Expression is restricted to the keratinocytes of the hair cortex and is absent from inner root sheath and medulla.2 Publications

Gene expression databases

BgeeiENSG00000094796.
CleanExiHS_KRT31.
GenevisibleiQ15323. HS.

Organism-specific databases

HPAiHPA049550.
HPA055194.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
Q53FW83EBI-948001,EBI-10242473
Q8N9J23EBI-948001,EBI-10268244
ABI2Q9NYB93EBI-948001,EBI-743598
AESQ081173EBI-948001,EBI-717810
AGR2O959945EBI-948001,EBI-712648
ALDH3B1P433533EBI-948001,EBI-2558314
ALS2CR11Q53TS85EBI-948001,EBI-739879
AMOTQ4VCS5-23EBI-948001,EBI-3891843
AMOTL2Q9Y2J4-43EBI-948001,EBI-10187270
ANKRD36BP1Q96IX93EBI-948001,EBI-744859
AQP1P299723EBI-948001,EBI-745213
AQP5P550643EBI-948001,EBI-746103
ARMC7Q9H6L43EBI-948001,EBI-742909
ARSJQ8N5N63EBI-948001,EBI-10266832
ASMTLO956715EBI-948001,EBI-743231
ASPSCR1Q9BZE93EBI-948001,EBI-1993677
ATG9AQ7Z3C63EBI-948001,EBI-727146
ATXN7L1Q9ULK23EBI-948001,EBI-310660
BEX2Q9BXY85EBI-948001,EBI-745073
BTCP350705EBI-948001,EBI-6590057
BYSLQ138953EBI-948001,EBI-358049
C12orf49Q9H7413EBI-948001,EBI-2836158
C19orf73Q9NVV23EBI-948001,EBI-2859285
C1orf109Q9NX045EBI-948001,EBI-8643161
C1orf216Q8TAB55EBI-948001,EBI-747505
C5orf60A6NFR6-43EBI-948001,EBI-10173955
C6orf165Q8IYR03EBI-948001,EBI-749051
CA6Q8N4G43EBI-948001,EBI-10265475
CARD9Q9H2573EBI-948001,EBI-751319
CATIPQ7Z7H35EBI-948001,EBI-10258233
CCDC112Q8NEF33EBI-948001,EBI-745040
CCDC120Q96HB5-43EBI-948001,EBI-10185348
CCDC17Q96LX73EBI-948001,EBI-719840
CCER1Q8TC903EBI-948001,EBI-746041
CCHCR1Q8TD31-35EBI-948001,EBI-10175300
CCNCP248635EBI-948001,EBI-395261
CD33P201385EBI-948001,EBI-3906571
CDC20BQ86Y333EBI-948001,EBI-10260504
CDK18Q070023EBI-948001,EBI-746238
CDKN1AP389365EBI-948001,EBI-375077
CEP57Q86XR83EBI-948001,EBI-308614
CEP57L1Q8IYX83EBI-948001,EBI-1104570
CEP57L1Q8IYX8-23EBI-948001,EBI-10181988
CEP70Q8NHQ13EBI-948001,EBI-739624
CHCHD2Q9Y6H13EBI-948001,EBI-2321769
CHRNGP075103EBI-948001,EBI-9008836
CLDN2P577393EBI-948001,EBI-751440
COA5Q86WW83EBI-948001,EBI-5458774
COMTP21964-23EBI-948001,EBI-10200977
COX5AP206743EBI-948001,EBI-715032
COX5BP106063EBI-948001,EBI-1053725
CRHP068503EBI-948001,EBI-3870390
CTSGP083113EBI-948001,EBI-5462635
DGCR6LQ9BY273EBI-948001,EBI-742953
DMRT3Q9NQL95EBI-948001,EBI-9679045
DTNBO609413EBI-948001,EBI-740402
EIF4E2O605733EBI-948001,EBI-398610
EXOC8Q8IYI63EBI-948001,EBI-742102
FAM103A1Q9BTL35EBI-948001,EBI-744023
FAM110AQ9BQ895EBI-948001,EBI-1752811
FAM124BQ9H5Z63EBI-948001,EBI-741626
FAM71CQ8NEG05EBI-948001,EBI-752049
FAM74A6Q5TZK33EBI-948001,EBI-10247271
FAM90A1Q86YD75EBI-948001,EBI-6658203
FARS2O953633EBI-948001,EBI-2513774
FBF1Q8TES7-63EBI-948001,EBI-10244131
FBXW5Q969U65EBI-948001,EBI-741068
FKBP1BP681063EBI-948001,EBI-6693977
FOXB1Q998533EBI-948001,EBI-3916225
GEMP550405EBI-948001,EBI-744104
GFOD1Q9NXC23EBI-948001,EBI-8799578
GLRX3O760033EBI-948001,EBI-374781
GNAI2P048993EBI-948001,EBI-353997
GNEQ9Y2233EBI-948001,EBI-4291090
GNG10P501513EBI-948001,EBI-10211741
GNG5P632183EBI-948001,EBI-10220734
GPS2Q132276EBI-948001,EBI-713355
GSTP1P092115EBI-948001,EBI-353467
HAUS1Q96CS23EBI-948001,EBI-2514791
HDAC4P565243EBI-948001,EBI-308629
HGSO149645EBI-948001,EBI-740220
HOXA1P496395EBI-948001,EBI-740785
HSPA12BQ96MM65EBI-948001,EBI-10291310
HSPD1P108093EBI-948001,EBI-352528
ICAM4Q14773-35EBI-948001,EBI-10233928
INPP5DQ928353EBI-948001,EBI-1380477
INPP5KQ9BT405EBI-948001,EBI-749162
INSRP062133EBI-948001,EBI-475899
JOSD1Q150403EBI-948001,EBI-2510602
KIFC3Q9BVG83EBI-948001,EBI-2125614
KLC1Q078663EBI-948001,EBI-721019
KLC4Q9NSK05EBI-948001,EBI-949319
KLHL38Q2WGJ65EBI-948001,EBI-6426443
KRT2P359085EBI-948001,EBI-1247312
KRT5P136475EBI-948001,EBI-702187
KRT6AP025387EBI-948001,EBI-702198
KRT6BP042595EBI-948001,EBI-740907
KRT6CP486685EBI-948001,EBI-2564105
KRT71Q3SY845EBI-948001,EBI-2952676
KRT77Q0IIN13EBI-948001,EBI-2511085
KRT79Q5XKE55EBI-948001,EBI-2514135
KRT8P057875EBI-948001,EBI-297852
KRT81Q145337EBI-948001,EBI-739648
KRT83P783855EBI-948001,EBI-10221390
LATS1Q6PJG33EBI-948001,EBI-10253976
LCE4AQ5TA783EBI-948001,EBI-10246358
LENG1Q96BZ85EBI-948001,EBI-726510
LIN37Q96GY33EBI-948001,EBI-748884
LINC00526Q96FQ75EBI-948001,EBI-10286106
LMF2Q9BU233EBI-948001,EBI-10298556
LMO4P619683EBI-948001,EBI-2798728
LONRF1Q17RB85EBI-948001,EBI-2341787
MAP3K7CLP57077-43EBI-948001,EBI-10215880
MAPKBP1O603365EBI-948001,EBI-947402
MARK4Q6IPE93EBI-948001,EBI-10250211
MARK4Q96GZ33EBI-948001,EBI-10286833
MGC13033Q4ZG743EBI-948001,EBI-10241963
MRPL40Q9NQ503EBI-948001,EBI-1053902
NAV1Q8NEY1-43EBI-948001,EBI-10270828
NAXDQ8IW453EBI-948001,EBI-8650724
NEK6Q9HC983EBI-948001,EBI-740364
NPBWR2P481465EBI-948001,EBI-10210114
OTUB2Q9BWI93EBI-948001,EBI-10300896
P2RX7C6KE323EBI-948001,EBI-10176325
PIN1Q135265EBI-948001,EBI-714158
PKN1Q165125EBI-948001,EBI-602382
PPP1R18Q6NYC85EBI-948001,EBI-2557469
PRF1P142225EBI-948001,EBI-724466
PRKAA2P546463EBI-948001,EBI-1383852
PRR19A6NJB73EBI-948001,EBI-10174045
PSMA1P257863EBI-948001,EBI-359352
PSMG2Q969U73EBI-948001,EBI-723276
PSPC1Q8WXF13EBI-948001,EBI-1392258
PTGER3Q147X85EBI-948001,EBI-10234038
PTPMT1Q8WUK05EBI-948001,EBI-7199479
RADILQ96JH85EBI-948001,EBI-744267
RCOR3Q9P2K33EBI-948001,EBI-743428
RIBC1Q8N4435EBI-948001,EBI-10265323
RPUSD3Q6P0873EBI-948001,EBI-5458784
RSPH14Q9UHP65EBI-948001,EBI-748350
SCNM1Q9BWG65EBI-948001,EBI-748391
SEMA4CQ9C0C45EBI-948001,EBI-10303490
SFRS2Q6NXQ03EBI-948001,EBI-10251550
SHC3Q925295EBI-948001,EBI-79084
SLC15A3Q05CH43EBI-948001,EBI-10223741
SLC23A1Q9UHI73EBI-948001,EBI-1759386
SLC25A6P122363EBI-948001,EBI-356254
SMARCE1Q969G35EBI-948001,EBI-455078
SMCPP499015EBI-948001,EBI-750494
SMG9Q9H0W85EBI-948001,EBI-2872322
SNAI1O958633EBI-948001,EBI-1045459
SNRNP25Q9BV903EBI-948001,EBI-9675976
SPATA24Q86W543EBI-948001,EBI-3916986
SPON2Q9BUD65EBI-948001,EBI-10298801
SSX2IPQ9Y2D83EBI-948001,EBI-2212028
THAP7Q9BT495EBI-948001,EBI-741350
TMEM106CQ9BVX25EBI-948001,EBI-2821497
TMEM231Q9H6L23EBI-948001,EBI-10307654
TMSB4XQ0P5Q03EBI-948001,EBI-10226570
TRAF4Q9BUZ43EBI-948001,EBI-3650647
TROAPQ128153EBI-948001,EBI-2349743
TSG101Q998165EBI-948001,EBI-346882
TTC23Q5W5X93EBI-948001,EBI-6447954
TXLNAP402225EBI-948001,EBI-359793
USHBP1Q8N6Y03EBI-948001,EBI-739895
UTP23Q9BRU93EBI-948001,EBI-5457544
UXTQ9UBK95EBI-948001,EBI-357355
WDR25Q64LD23EBI-948001,EBI-744560
WDYHV1Q96HA83EBI-948001,EBI-741158
ZFYVE21Q9BQ243EBI-948001,EBI-2849569
ZNF124Q159733EBI-948001,EBI-2555767
ZNF148Q9UQR13EBI-948001,EBI-2688184
ZNF20P170243EBI-948001,EBI-717634
ZNF569Q5MCW45EBI-948001,EBI-4395687
ZNF572Q7Z3I73EBI-948001,EBI-10257016
ZNF69Q9UC073EBI-948001,EBI-10320266

Protein-protein interaction databases

BioGridi110079. 198 interactors.
IntActiQ15323. 333 interactors.
MINTiMINT-2860287.
STRINGi9606.ENSP00000251645.

Structurei

3D structure databases

ProteinModelPortaliQ15323.
SMRiQ15323.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 56HeadAdd BLAST56
Regioni57 – 363RodAdd BLAST307
Regioni57 – 91Coil 1AAdd BLAST35
Regioni92 – 102Linker 1Add BLAST11
Regioni103 – 203Coil 1BAdd BLAST101
Regioni204 – 219Linker 12Add BLAST16
Regioni220 – 363Coil 2Add BLAST144
Regioni364 – 416TailAdd BLAST53

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ15323.
KOiK07604.
OMAiITSPCTM.
OrthoDBiEOG091G087I.
PhylomeDBiQ15323.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15323-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYNFCLPSL SCRTSCSSRP CVPPSCHSCT LPGACNIPAN VSNCNWFCEG
60 70 80 90 100
SFNGSEKETM QFLNDRLASY LEKVRQLERD NAELENLIRE RSQQQEPLLC
110 120 130 140 150
PSYQSYFKTI EELQQKILCT KSENARLVVQ IDNAKLAADD FRTKYQTELS
160 170 180 190 200
LRQLVESDIN GLRRILDELT LCKSDLEAQV ESLKEELLCL KSNHEQEVNT
210 220 230 240 250
LRCQLGDRLN VEVDAAPTVD LNRVLNETRS QYEALVETNR REVEQWFTTQ
260 270 280 290 300
TEELNKQVVS SSEQLQSYQA EIIELRRTVN ALEIELQAQH NLRDSLENTL
310 320 330 340 350
TESEARYSSQ LSQVQSLITN VESQLAEIRS DLERQNQEYQ VLLDVRARLE
360 370 380 390 400
CEINTYRSLL ESEDCNLPSN PCATTNACSK PIGPCLSNPC TSCVPPAPCT
410
PCAPRPRCGP CNSFVR
Length:416
Mass (Da):47,237
Last modified:October 14, 2008 - v3
Checksum:iC284DD33A4896009
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti153 – 154QL → HV in CAA60378 (PubMed:7578244).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04698939A → G.Corresponds to variant rs6503628dbSNPEnsembl.1
Natural variantiVAR_04699082A → V.Corresponds to variant rs6503627dbSNPEnsembl.1
Natural variantiVAR_046991377A → V.Corresponds to variant rs34293483dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86570 mRNA. Translation: CAA60378.1.
Y16787 Genomic DNA. Translation: CAA76383.1.
CH471152 Genomic DNA. Translation: EAW60730.1.
BC114468 mRNA. Translation: AAI14469.1.
CCDSiCCDS11391.1.
PIRiS60034.
RefSeqiNP_002268.2. NM_002277.2.
UniGeneiHs.41696.

Genome annotation databases

EnsembliENST00000251645; ENSP00000251645; ENSG00000094796.
ENST00000573281; ENSP00000460739; ENSG00000262993.
GeneIDi3881.
KEGGihsa:3881.
UCSCiuc002hwn.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86570 mRNA. Translation: CAA60378.1.
Y16787 Genomic DNA. Translation: CAA76383.1.
CH471152 Genomic DNA. Translation: EAW60730.1.
BC114468 mRNA. Translation: AAI14469.1.
CCDSiCCDS11391.1.
PIRiS60034.
RefSeqiNP_002268.2. NM_002277.2.
UniGeneiHs.41696.

3D structure databases

ProteinModelPortaliQ15323.
SMRiQ15323.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110079. 198 interactors.
IntActiQ15323. 333 interactors.
MINTiMINT-2860287.
STRINGi9606.ENSP00000251645.

PTM databases

iPTMnetiQ15323.
PhosphoSitePlusiQ15323.
SwissPalmiQ15323.

Polymorphism and mutation databases

BioMutaiKRT31.
DMDMi209572740.

Proteomic databases

PaxDbiQ15323.
PeptideAtlasiQ15323.
PRIDEiQ15323.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000251645; ENSP00000251645; ENSG00000094796.
ENST00000573281; ENSP00000460739; ENSG00000262993.
GeneIDi3881.
KEGGihsa:3881.
UCSCiuc002hwn.4. human.

Organism-specific databases

CTDi3881.
DisGeNETi3881.
GeneCardsiKRT31.
H-InvDBHIX0039252.
HGNCiHGNC:6448. KRT31.
HPAiHPA049550.
HPA055194.
MIMi601077. gene.
neXtProtiNX_Q15323.
OpenTargetsiENSG00000094796.
ENSG00000262993.
PharmGKBiPA30237.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IF9P. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ15323.
KOiK07604.
OMAiITSPCTM.
OrthoDBiEOG091G087I.
PhylomeDBiQ15323.
TreeFamiTF332742.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000094796-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GeneWikiiKRT31.
GenomeRNAii3881.
PROiQ15323.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000094796.
CleanExiHS_KRT31.
GenevisibleiQ15323. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiK1H1_HUMAN
AccessioniPrimary (citable) accession number: Q15323
Secondary accession number(s): Q9UE12
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: October 14, 2008
Last modified: November 30, 2016
This is version 135 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.