Reviewed,
UniProtKB/Swiss-Prot Q15306 (IRF4_HUMAN)
Last modified
November 25, 2008.
Version 89.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Interferon regulatory factor 4 Short name=IRF-4 Alternative name(s): Lymphocyte-specific interferon regulatory factor Short name=LSIRF NF-EM5 Multiple myeloma oncogene 1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 451 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Transcriptional activator. Binds to the interferon-stimulated response element (ISRE) of the MHC class I promoter. Binds the immunoglobulin lambda light chain enhancer, together with PU.1. Probably plays a role in ISRE-targeted signal transduction mechanisms specific to lymphoid cells. |
| Subunit structure | Interacts with SPIB and DEF6. |
| Subcellular location | |
| Tissue specificity | Lymphoid cells. |
| Induction | Not induced by interferons. |
| Involvement in disease | A chromosomal aberration involving IRF4 may be a cause of multiple myeloma [MIM:254500]. Translocation t(6;14)(p25;q32) with the IgH locus. |
| Sequence similarities | Belongs to the IRF family. Contains 1 tryptophan pentad repeat DNA-binding domain. |
Ontologies
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform 1 (identifier: Q15306-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform 2 (identifier: Q15306-2) The sequence of this isoform differs from the canonical sequence as follows: 165-165: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||||||||||||||||||||||||
Molecule processing | |||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 451 | 451 | Interferon regulatory factor 4 | PRO_0000154556 | |||||||||||||||||||||||||||||
Regions | |||||||||||||||||||||||||||||||||
| DNA binding | 23 – 125 | 103 | Tryptophan pentad repeat | ||||||||||||||||||||||||||||||
Natural variations | |||||||||||||||||||||||||||||||||
| Alternative sequence | 165 | 1 | Missing in isoform 2. | VSP_002755 | |||||||||||||||||||||||||||||
Experimental info | |||||||||||||||||||||||||||||||||
| Sequence conflict | 300 | 1 | Q → H in AAB37258. Ref.2 | ||||||||||||||||||||||||||||||
| Sequence conflict | 306 | 1 | K → N in AAB37258. Ref.2 | ||||||||||||||||||||||||||||||
| Sequence conflict | 333 | 1 | R → T in AAB37258. Ref.2 | ||||||||||||||||||||||||||||||
Secondary structure | |||||||||||||||||||||||||||||||||
Helix Strand Turn | |||||||||||||||||||||||||||||||||
| Helix | 24 – 34 | 11 | |||||||||||||||||||||||||||||||
| Beta strand | 37 – 39 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 41 – 47 | 7 | |||||||||||||||||||||||||||||||
| Beta strand | 49 – 53 | 5 | |||||||||||||||||||||||||||||||
| Beta strand | 60 – 62 | 3 | |||||||||||||||||||||||||||||||
| Helix | 64 – 67 | 4 | |||||||||||||||||||||||||||||||
| Helix | 69 – 78 | 10 | |||||||||||||||||||||||||||||||
| Helix | 90 – 103 | 14 | |||||||||||||||||||||||||||||||
| Beta strand | 107 – 109 | 3 | |||||||||||||||||||||||||||||||
| Turn | 111 – 113 | 3 | |||||||||||||||||||||||||||||||
| Beta strand | 115 – 120 | 6 | |||||||||||||||||||||||||||||||
| Beta strand | 122 – 127 | 6 | |||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Cloning of human lymphocyte-specific interferon regulatory factor (hLSIRF/hIRF4) and mapping of the gene to 6p23-p25." Grossman A., Mittrucker H.W., Nicholl J., Suzuki A., Chung S., Antonio L., Sugga S., Sutherland G.R., Siderovski D.P., Mak T.W. Genomics 37:229-233(1996) [PubMed: 8921401] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2). Tissue: Spleen. |
| [2] | "Deregulation of MUM1/IRF4 by chromosomal translocation in multiple myeloma." Iida S., Rao P.H., Butler M., Corradini P., Boccadoro M., Klein B., Chaganti R.S.K., Dalla-Favera R. Nat. Genet. 17:226-230(1997) [PubMed: 9326949] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), INVOLVEMENT IN MULTIPLE MYELOMA. Tissue: Spleen. |
| [3] | "The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. Beck S.Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [4] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Skin. |
| [5] | "SPI-B activates transcription via a unique proline, serine, and threonine domain and exhibits DNA binding affinity differences from PU.1." Rao S., Matsumura A., Yoon J., Simon M.C. J. Biol. Chem. 274:11115-11124(1999) [PubMed: 10196196] [Abstract] Cited for: INTERACTION WITH SPIB. |
| [6] | "Molecular cloning of IBP, a SWAP-70 homologous GEF, which is highly expressed in the immune system." Gupta S., Lee A.E., Hu C., Fanzo J.C., Goldberg I., Cattoretti G., Pernis A.B. Hum. Immunol. 64:389-401(2003) [PubMed: 12651066] [Abstract] Cited for: INTERACTION WITH DEF6. Tissue: Lymph node. |
| [7] | "Solution structure of the IRF domain of human interferon regulator factors 4." RIKEN structural genomics initiative (RSGI) Submitted (OCT-2006) to the PDB data bank Cited for: STRUCTURE BY NMR OF 22-130. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| U52682 mRNA. Translation: AAC50779.1. U63738 mRNA. Translation: AAB37258.1. AL589962, AL365272 Genomic DNA. Translation: CAH71554.1. AL365272, AL589962 Genomic DNA. Translation: CAH72537.1. BC015752 mRNA. Translation: AAH15752.1. | |||||||||||||
| RefSeq | NP_002451.2. | ||||||||||||
| UniGene | Hs.401013 | ||||||||||||
3D structure databases | |||||||||||||
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| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | Q15306. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | Q15306. | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENSG00000137265. Homo sapiens. [Contig view] | ||||||||||||
| GeneID | 3662. | ||||||||||||
| KEGG | hsa:3662. | ||||||||||||
Organism-specific databases | |||||||||||||
| H-InvDB | HIX0005514. | ||||||||||||
| HGNC | HGNC:6119. IRF4. | ||||||||||||
| HPA | CAB013508. HPA002038. HPA002698. | ||||||||||||
| MIM | 254500. phenotype. 601900. gene. | ||||||||||||
| Orphanet | 29073. Myeloma, multiple. | ||||||||||||
| PharmGKB | PA29918. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
| GeneCards | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| HOGENOM | Q15306. | ||||||||||||
| HOVERGEN | Q15306. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | Q15306. | ||||||||||||
| CleanEx | HS_IRF4. HS_MUM1. | ||||||||||||
| GermOnline | ENSG00000137265. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR001346. IRF. IPR017855. SMAD_dom-like. IPR011991. Wing_hlx_DNA_bd. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:2.60.200.10. MH2_Dwarfin-type. 1 hit. G3DSA:1.10.10.10. Wing_hlx_DNA_bd. 1 hit. | ||||||||||||
| Pfam | PF00605. IRF. 1 hit. [Graphical view] | ||||||||||||
| PRINTS | PR00267. INTFRNREGFCT. | ||||||||||||
| ProDom | PD002355. IRF. 1 hit. [Graphical view] [Entries sharing at least one domain] | ||||||||||||
| SMART | SM00348. IRF. 1 hit. [Graphical view] | ||||||||||||
| PROSITE | PS00601. IRF. 1 hit. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other Resources | |||||||||||||
| NextBio | 14323. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | IRF4_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15306 Secondary accession number(s): Q5VUI7, Q99660 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 6 Human chromosome 6: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


