Reviewed,
UniProtKB/Swiss-Prot Q15293 (RCN1_HUMAN)
Last modified
December 15, 2009.
Version 87.
History...
Clusters with 100%,
90%,
50% identity |
Documents (5) |
Third-party data |
Customize display | text xml rdf/xml gff fasta |
Names and origin
| Protein names | Recommended name: Reticulocalbin-1 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 331 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment. |
| Subcellular location | |
| Miscellaneous | This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium By similarity. |
| Sequence similarities | Belongs to the CREC family. Contains 6 EF-hand domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum |
| Coding sequence diversity | Polymorphism |
| Domain | Repeat Signal |
| Ligand | Calcium |
| PTM | Acetylation Glycoprotein |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Cellular component | endoplasmic reticulum lumen Traceable author statement. Source: ProtInc |
| Molecular function | calcium ion binding Traceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 29 | 29 | Potential | ||||||
| Chain | 30 – 331 | 302 | Reticulocalbin-1 | PRO_0000004145 | |||||
Regions | |||||||||
| Domain | 79 – 114 | 36 | EF-hand 1 | ||||||
| Domain | 115 – 150 | 36 | EF-hand 2 | ||||||
| Domain | 166 – 201 | 36 | EF-hand 3 | ||||||
| Domain | 203 – 238 | 36 | EF-hand 4 | ||||||
| Domain | 244 – 279 | 36 | EF-hand 5 | ||||||
| Domain | 280 – 315 | 36 | EF-hand 6 | ||||||
| Calcium binding | 92 – 103 | 12 | 1 Potential | ||||||
| Calcium binding | 128 – 139 | 12 | 2; possibly ancestral Potential | ||||||
| Calcium binding | 179 – 190 | 12 | 3 Potential | ||||||
| Calcium binding | 216 – 227 | 12 | 4 Potential | ||||||
| Calcium binding | 257 – 268 | 12 | 5 Potential | ||||||
| Calcium binding | 293 – 304 | 12 | 6; possibly ancestral Potential | ||||||
| Motif | 328 – 331 | 4 | Prevents secretion from ER | ||||||
Amino acid modifications | |||||||||
| Modified residue | 86 | 1 | N6-acetyllysine Ref.6 | ||||||
| Glycosylation | 53 | 1 | N-linked (GlcNAc...) Ref.5 | ||||||
Natural variations | |||||||||
| Natural variant | 71 | 1 | T → N: dbSNP rs1061145. | VAR_011964 | |||||
| Natural variant | 73 | 1 | D → Y: dbSNP rs1804281. | VAR_011965 | |||||
| Natural variant | 74 | 1 | Q → E: dbSNP rs1061143. | VAR_011966 | |||||
| Natural variant | 117 | 1 | F → L in a colorectal cancer sample; somatic mutation. Ref.7 | VAR_035460 | |||||
| Natural variant | 188 | 1 | R → P: dbSNP rs1061080. | VAR_011967 | |||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Cloning of a human homologue of mouse reticulocalbin reveals conservation of structural domains in the novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs." Ozawa M. J. Biochem. 117:1113-1119(1995) [PubMed: 8586628] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Human chromosome 11 DNA sequence and analysis including novel gene identification." Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. Sakaki Y.Nature 440:497-500(2006) [PubMed: 16554811] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary. |
| [4] | Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY. |
| [5] | "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed: 19159218] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53, MASS SPECTROMETRY. Tissue: Liver. |
| [6] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-86, MASS SPECTROMETRY. |
| [7] | "The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. Velculescu V.E.Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-117. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| D42073 mRNA. Translation: BAA07670.1. AL078612 Genomic DNA. No translation available. BC010120 mRNA. Translation: AAH10120.1. | |
| IPI | IPI00015842. |
| PIR | JC4173. |
| RefSeq | NP_002892.1. |
| UniGene | Hs.97887 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q15293. 2 interactions. |
| STRING | Q15293. |
PTM databases | |
| PhosphoSite | Q15293. |
Proteomic databases | |
| PeptideAtlas | Q15293. |
| PRIDE | Q15293. |
Genome annotation databases | |
| Ensembl | ENST00000054950; ENSP00000054950; ENSG00000049449; Homo sapiens. [Genome view] |
| GeneID | 5954. |
| KEGG | hsa:5954. |
| UCSC | uc001mtj.1. human. |
Organism-specific databases | |
| CTD | 5954. |
| GeneCards | GC11P032069. |
| H-InvDB | HIX0009530. HIX0036571. HIX0079521. |
| HGNC | HGNC:9934. RCN1. |
| MIM | 602735. gene. |
| PharmGKB | PA24931. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | HBG388084. |
| HOVERGEN | Q15293. |
| InParanoid | Q15293. |
| OMA | NPEEFQD. |
| OrthoDB | EOG9ZCWPT. |
Gene expression databases | |
| ArrayExpress | Q15293. |
| Bgee | Q15293. |
| CleanEx | HS_RCN1. |
| Genevestigator | Q15293. |
| GermOnline | ENSG00000049449. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR011992. EF-Hand_type. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR002048. EF_hand_Ca_bd. IPR018248. EF_Hand_dom. [Graphical view] |
| Gene3D | G3DSA:1.10.238.10. EF-Hand_type. 1 hit. |
| Pfam | PF00036. efhand. 1 hit. [Graphical view] |
| SMART | SM00054. EFh. 3 hits. [Graphical view] |
| PROSITE | PS00018. EF_HAND_1. 4 hits. PS50222. EF_HAND_2. 6 hits. PS00014. ER_TARGET. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 23188. |
| SOURCE | Search... |
Entry information
| Entry name | RCN1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15293 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 11 Human chromosome 11: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


