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Q15293 (RCN1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Reticulocalbin-1
Gene names
Name:RCN1
Synonyms:RCN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length331 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.

Subcellular location

Endoplasmic reticulum lumen.

Miscellaneous

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium By similarity.

Sequence similarities

Belongs to the CREC family.

Contains 6 EF-hand domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ATXN1P542533EBI-948278,EBI-930964

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2929 Potential
Chain30 – 331302Reticulocalbin-1
PRO_0000004145

Regions

Domain79 – 11436EF-hand 1
Domain115 – 15036EF-hand 2
Domain166 – 20136EF-hand 3
Domain203 – 23836EF-hand 4
Domain244 – 27936EF-hand 5
Domain280 – 31536EF-hand 6
Calcium binding92 – 103121 Potential
Calcium binding128 – 139122; possibly ancestral Potential
Calcium binding179 – 190123 Potential
Calcium binding216 – 227124 Potential
Calcium binding257 – 268125 Potential
Calcium binding293 – 304126; possibly ancestral Potential
Motif328 – 3314Prevents secretion from ER

Amino acid modifications

Modified residue761Phosphothreonine Ref.6
Glycosylation531N-linked (GlcNAc...) Ref.5

Natural variations

Natural variant711T → N.
Corresponds to variant rs1061145 [ dbSNP | Ensembl ].
VAR_011964
Natural variant731D → Y.
Corresponds to variant rs1804281 [ dbSNP | Ensembl ].
VAR_011965
Natural variant741Q → E.
Corresponds to variant rs1061143 [ dbSNP | Ensembl ].
VAR_011966
Natural variant1171F → L in a colorectal cancer sample; somatic mutation. Ref.8
VAR_035460
Natural variant1881R → P.
Corresponds to variant rs1061080 [ dbSNP | Ensembl ].
VAR_011967

Sequences

Sequence LengthMass (Da)Tools
Q15293 [UniParc].

Last modified November 1, 1997. Version 1.
Checksum: 608AAD536963F789

FASTA33138,890
        10         20         30         40         50         60 
MARGGRGRRL GLALGLLLAL VLAPRVLRAK PTVRKERVVR PDSELGERPP EDNQSFQYDH 

        70         80         90        100        110        120 
EAFLGKEDSK TFDQLTPDES KERLGKIVDR IDNDGDGFVT TEELKTWIKR VQKRYIFDNV 

       130        140        150        160        170        180 
AKVWKDYDRD KDDKISWEEY KQATYGYYLG NPAEFHDSSD HHTFKKMLPR DERRFKAADL 

       190        200        210        220        230        240 
NGDLTATREE FTAFLHPEEF EHMKEIVVLE TLEDIDKNGD GFVDQDEYIA DMFSHEENGP 

       250        260        270        280        290        300 
EPDWVLSERE QFNEFRDLNK DGKLDKDEIR HWILPQDYDH AQAEARHLVY ESDKNKDEKL 

       310        320        330 
TKEEILENWN MFVGSQATNY GEDLTKNHDE L 

« Hide

References

« Hide 'large scale' references
[1]"Cloning of a human homologue of mouse reticulocalbin reveals conservation of structural domains in the novel endoplasmic reticulum resident Ca(2+)-binding protein with multiple EF-hand motifs."
Ozawa M.
J. Biochem. 117:1113-1119(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D., Noguchi H., Totoki Y., Toyoda A., Kuroki Y., Dewar K., Lloyd C., Itoh T., Takeda T., Kim D.-W., She X., Barlow K.F., Bloom T., Bruford E., Chang J.L., Cuomo C.A., Eichler E., FitzGerald M.G. expand/collapse author list , Jaffe D.B., LaButti K., Nicol R., Park H.-S., Seaman C., Sougnez C., Yang X., Zimmer A.R., Zody M.C., Birren B.W., Nusbaum C., Fujiyama A., Hattori M., Rogers J., Lander E.S., Sakaki Y.
Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Ovary.
[5]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-53.
Tissue: Liver.
[6]"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-76, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Cervix carcinoma.
[7]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[8]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT [LARGE SCALE ANALYSIS] LEU-117.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D42073 mRNA. Translation: BAA07670.1.
AL078612 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68227.1.
CH471064 Genomic DNA. Translation: EAW68228.1.
BC010120 mRNA. Translation: AAH10120.1.
PIRJC4173.
RefSeqNP_002892.1. NM_002901.2.
UniGeneHs.97887.

3D structure databases

ProteinModelPortalQ15293.
SMRQ15293. Positions 73-310.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111887. 45 interactions.
IntActQ15293. 19 interactions.
MINTMINT-2862561.
STRING9606.ENSP00000054950.

PTM databases

PhosphoSiteQ15293.

Polymorphism databases

DMDM2493462.

Proteomic databases

PaxDbQ15293.
PeptideAtlasQ15293.
PRIDEQ15293.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000054950; ENSP00000054950; ENSG00000049449.
GeneID5954.
KEGGhsa:5954.
UCSCuc010reb.2. human.

Organism-specific databases

CTD5954.
GeneCardsGC11P031815.
HGNCHGNC:9934. RCN1.
HPAHPA038474.
MIM602735. gene.
neXtProtNX_Q15293.
PharmGKBPA34303.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG271367.
HOGENOMHOG000230934.
HOVERGENHBG002834.
InParanoidQ15293.
OMANPEEFQD.
PhylomeDBQ15293.
TreeFamTF314849.

Gene expression databases

ArrayExpressQ15293.
BgeeQ15293.
CleanExHS_RCN1.
GenevestigatorQ15293.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR028332. Rcn1_mml.
[Graphical view]
PANTHERPTHR10827:SF18. PTHR10827:SF18. 1 hit.
PfamPF13405. EF-hand_6. 1 hit.
PF13499. EF-hand_7. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 3 hits.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiRCN1.
GenomeRNAi5954.
NextBio23188.
PROQ15293.
SOURCESearch...

Entry information

Entry nameRCN1_HUMAN
AccessionPrimary (citable) accession number: Q15293
Secondary accession number(s): D3DR00
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: April 16, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM