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Protein

Reticulocalbin-1

Gene

RCN1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate calcium-dependent activities in the endoplasmic reticulum lumen or post-ER compartment.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi92 – 1031PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi128 – 1392; possibly ancestralPROSITE-ProRule annotationAdd BLAST12
Calcium bindingi179 – 1903PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi216 – 2274PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi257 – 2685PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi293 – 3046; possibly ancestralPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • calcium ion binding Source: ProtInc

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000049449-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Reticulocalbin-1
Gene namesi
Name:RCN1
Synonyms:RCN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:9934. RCN1.

Subcellular locationi

GO - Cellular componenti

  • endoplasmic reticulum Source: HPA
  • endoplasmic reticulum lumen Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum

Pathology & Biotechi

Organism-specific databases

DisGeNETi5954.
OpenTargetsiENSG00000049449.
PharmGKBiPA34303.

Polymorphism and mutation databases

BioMutaiRCN1.
DMDMi2493462.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
ChainiPRO_000000414530 – 331Reticulocalbin-1Add BLAST302

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi53N-linked (GlcNAc...)1 Publication1
Modified residuei55PhosphoserineCombined sources1
Modified residuei76PhosphothreonineCombined sources1
Modified residuei80Phosphoserine; by FAM20CCombined sources1 Publication1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15293.
PaxDbiQ15293.
PeptideAtlasiQ15293.
PRIDEiQ15293.
TopDownProteomicsiQ15293-1. [Q15293-1]

PTM databases

iPTMnetiQ15293.
PhosphoSitePlusiQ15293.

Expressioni

Gene expression databases

BgeeiENSG00000049449.
CleanExiHS_RCN1.
ExpressionAtlasiQ15293. baseline and differential.
GenevisibleiQ15293. HS.

Organism-specific databases

HPAiHPA038474.
HPA062104.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ATXN1P542533EBI-948278,EBI-930964

Protein-protein interaction databases

BioGridi111887. 111 interactors.
IntActiQ15293. 45 interactors.
MINTiMINT-2862561.
STRINGi9606.ENSP00000054950.

Structurei

3D structure databases

ProteinModelPortaliQ15293.
SMRiQ15293.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini79 – 114EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini115 – 150EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini166 – 201EF-hand 3PROSITE-ProRule annotationAdd BLAST36
Domaini203 – 238EF-hand 4PROSITE-ProRule annotationAdd BLAST36
Domaini244 – 279EF-hand 5PROSITE-ProRule annotationAdd BLAST36
Domaini280 – 315EF-hand 6PROSITE-ProRule annotationAdd BLAST36

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi328 – 331Prevents secretion from ER4

Sequence similaritiesi

Belongs to the CREC family.Curated
Contains 6 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ15293.
OMAiIADMFAH.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ15293.
TreeFamiTF314849.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR027241. Rcn1.
[Graphical view]
PANTHERiPTHR10827:SF17. PTHR10827:SF17. 1 hit.
PfamiPF13202. EF-hand_5. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15293-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARGGRGRRL GLALGLLLAL VLAPRVLRAK PTVRKERVVR PDSELGERPP
60 70 80 90 100
EDNQSFQYDH EAFLGKEDSK TFDQLTPDES KERLGKIVDR IDNDGDGFVT
110 120 130 140 150
TEELKTWIKR VQKRYIFDNV AKVWKDYDRD KDDKISWEEY KQATYGYYLG
160 170 180 190 200
NPAEFHDSSD HHTFKKMLPR DERRFKAADL NGDLTATREE FTAFLHPEEF
210 220 230 240 250
EHMKEIVVLE TLEDIDKNGD GFVDQDEYIA DMFSHEENGP EPDWVLSERE
260 270 280 290 300
QFNEFRDLNK DGKLDKDEIR HWILPQDYDH AQAEARHLVY ESDKNKDEKL
310 320 330
TKEEILENWN MFVGSQATNY GEDLTKNHDE L
Length:331
Mass (Da):38,890
Last modified:November 1, 1997 - v1
Checksum:i608AAD536963F789
GO
Isoform 2 (identifier: Q15293-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-85: MARGGRGRRL...TPDESKERLG → MTGGEGPLPTAKQATCSPPSSRERNPRRRGSRPR

Note: No experimental confirmation available.
Show »
Length:280
Mass (Da):33,026
Checksum:iE62F120400DF5918
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_01196573D → Y.Corresponds to variant rs1804281dbSNPEnsembl.1
Natural variantiVAR_035460117F → L in a colorectal cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0555111 – 85MARGG…KERLG → MTGGEGPLPTAKQATCSPPS SRERNPRRRGSRPR in isoform 2. 1 PublicationAdd BLAST85

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42073 mRNA. Translation: BAA07670.1.
AK293652 mRNA. Translation: BAH11557.1.
AL035078 Genomic DNA. No translation available.
AL049635 Genomic DNA. No translation available.
AL078612 Genomic DNA. No translation available.
AL138970 Genomic DNA. No translation available.
Z95332 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68227.1.
CH471064 Genomic DNA. Translation: EAW68228.1.
BC010120 mRNA. Translation: AAH10120.1.
CCDSiCCDS7876.1. [Q15293-1]
PIRiJC4173.
RefSeqiNP_002892.1. NM_002901.2. [Q15293-1]
UniGeneiHs.97887.

Genome annotation databases

EnsembliENST00000054950; ENSP00000054950; ENSG00000049449. [Q15293-1]
ENST00000532942; ENSP00000436422; ENSG00000049449. [Q15293-2]
GeneIDi5954.
KEGGihsa:5954.
UCSCiuc058acp.1. human. [Q15293-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D42073 mRNA. Translation: BAA07670.1.
AK293652 mRNA. Translation: BAH11557.1.
AL035078 Genomic DNA. No translation available.
AL049635 Genomic DNA. No translation available.
AL078612 Genomic DNA. No translation available.
AL138970 Genomic DNA. No translation available.
Z95332 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68227.1.
CH471064 Genomic DNA. Translation: EAW68228.1.
BC010120 mRNA. Translation: AAH10120.1.
CCDSiCCDS7876.1. [Q15293-1]
PIRiJC4173.
RefSeqiNP_002892.1. NM_002901.2. [Q15293-1]
UniGeneiHs.97887.

3D structure databases

ProteinModelPortaliQ15293.
SMRiQ15293.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111887. 111 interactors.
IntActiQ15293. 45 interactors.
MINTiMINT-2862561.
STRINGi9606.ENSP00000054950.

PTM databases

iPTMnetiQ15293.
PhosphoSitePlusiQ15293.

Polymorphism and mutation databases

BioMutaiRCN1.
DMDMi2493462.

Proteomic databases

EPDiQ15293.
PaxDbiQ15293.
PeptideAtlasiQ15293.
PRIDEiQ15293.
TopDownProteomicsiQ15293-1. [Q15293-1]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000054950; ENSP00000054950; ENSG00000049449. [Q15293-1]
ENST00000532942; ENSP00000436422; ENSG00000049449. [Q15293-2]
GeneIDi5954.
KEGGihsa:5954.
UCSCiuc058acp.1. human. [Q15293-1]

Organism-specific databases

CTDi5954.
DisGeNETi5954.
GeneCardsiRCN1.
HGNCiHGNC:9934. RCN1.
HPAiHPA038474.
HPA062104.
MIMi602735. gene.
neXtProtiNX_Q15293.
OpenTargetsiENSG00000049449.
PharmGKBiPA34303.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4223. Eukaryota.
ENOG410XRVE. LUCA.
GeneTreeiENSGT00550000074546.
HOGENOMiHOG000230934.
HOVERGENiHBG002834.
InParanoidiQ15293.
OMAiIADMFAH.
OrthoDBiEOG091G0GUL.
PhylomeDBiQ15293.
TreeFamiTF314849.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000049449-MONOMER.

Miscellaneous databases

GeneWikiiRCN1.
GenomeRNAii5954.
PROiQ15293.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000049449.
CleanExiHS_RCN1.
ExpressionAtlasiQ15293. baseline and differential.
GenevisibleiQ15293. HS.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR027241. Rcn1.
[Graphical view]
PANTHERiPTHR10827:SF17. PTHR10827:SF17. 1 hit.
PfamiPF13202. EF-hand_5. 3 hits.
[Graphical view]
SMARTiSM00054. EFh. 3 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 2 hits.
PROSITEiPS00018. EF_HAND_1. 4 hits.
PS50222. EF_HAND_2. 6 hits.
PS00014. ER_TARGET. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRCN1_HUMAN
AccessioniPrimary (citable) accession number: Q15293
Secondary accession number(s): B7Z1M1, D3DR00
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

This protein has four functional calcium-binding sites; potential sites II and VI have lost affinity for calcium.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.