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Protein

Ras GTPase-activating protein 2

Gene

RASA2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri708 – 744Btk-typePROSITE-ProRule annotationAdd BLAST37

GO - Molecular functioni

GO - Biological processi

  • MAPK cascade Source: Reactome
  • negative regulation of Ras protein signal transduction Source: GO_Central
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionGTPase activation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5658442 Regulation of RAS by GAPs
R-HSA-6802949 Signaling by RAS mutants

Names & Taxonomyi

Protein namesi
Recommended name:
Ras GTPase-activating protein 2
Alternative name(s):
GTPase-activating protein 1m
Short name:
GAP1m
Gene namesi
Name:RASA2
Synonyms:GAP1M, RASGAP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000155903.11
HGNCiHGNC:9872 RASA2
MIMi601589 gene
neXtProtiNX_Q15283

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5922
MalaCardsiRASA2
OpenTargetsiENSG00000155903
Orphaneti648 Noonan syndrome
PharmGKBiPA34233

Polymorphism and mutation databases

BioMutaiRASA2
DMDMi519668674

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00000566382 – 850Ras GTPase-activating protein 2Add BLAST849

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Modified residuei555PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ15283
PaxDbiQ15283
PeptideAtlasiQ15283
PRIDEiQ15283
ProteomicsDBi60511

PTM databases

iPTMnetiQ15283
PhosphoSitePlusiQ15283

Expressioni

Gene expression databases

BgeeiENSG00000155903
CleanExiHS_RASA2
ExpressionAtlasiQ15283 baseline and differential
GenevisibleiQ15283 HS

Organism-specific databases

HPAiHPA035374
HPA035375

Interactioni

Protein-protein interaction databases

BioGridi111857, 1 interactor
STRINGi9606.ENSP00000286364

Structurei

3D structure databases

ProteinModelPortaliQ15283
SMRiQ15283
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini25 – 122C2 1PROSITE-ProRule annotationAdd BLAST98
Domaini158 – 273C2 2PROSITE-ProRule annotationAdd BLAST116
Domaini356 – 550Ras-GAPPROSITE-ProRule annotationAdd BLAST195
Domaini604 – 706PHPROSITE-ProRule annotationAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi2 – 26Ala-richAdd BLAST25

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri708 – 744Btk-typePROSITE-ProRule annotationAdd BLAST37

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG2059 Eukaryota
ENOG410Y128 LUCA
GeneTreeiENSGT00760000119092
HOGENOMiHOG000007183
HOVERGENiHBG055643
InParanoidiQ15283
KOiK08053
PhylomeDBiQ15283
TreeFamiTF105302

Family and domain databases

CDDicd13370 PH_GAP1m_mammal-like, 1 hit
Gene3Di2.30.29.30, 1 hit
2.60.40.150, 2 hits
InterProiView protein in InterPro
IPR000008 C2_dom
IPR035892 C2_domain_sf
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR037773 RASA2_PH
IPR023152 RasGAP_CS
IPR001936 RasGAP_dom
IPR008936 Rho_GTPase_activation_prot
IPR001562 Znf_Btk_motif
PfamiView protein in Pfam
PF00779 BTK, 1 hit
PF00168 C2, 2 hits
PF00169 PH, 1 hit
PF00616 RasGAP, 2 hits
PRINTSiPR00402 TECBTKDOMAIN
SMARTiView protein in SMART
SM00107 BTK, 1 hit
SM00239 C2, 2 hits
SM00233 PH, 1 hit
SM00323 RasGAP, 1 hit
SUPFAMiSSF48350 SSF48350, 1 hit
PROSITEiView protein in PROSITE
PS50004 C2, 2 hits
PS50003 PH_DOMAIN, 1 hit
PS00509 RAS_GTPASE_ACTIV_1, 1 hit
PS50018 RAS_GTPASE_ACTIV_2, 1 hit
PS51113 ZF_BTK, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15283-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAAAPAAAA ASSEAPAASA TAEPEAGDQD SREVRVLQSL RGKICEAKNL
60 70 80 90 100
LPYLGPHKMR DCFCTINLDQ EEVYRTQVVE KSLSPFFSEE FYFEIPRTFQ
110 120 130 140 150
YLSFYVYDKN VLQRDLRIGK VAIKKEDLCN HSGKETWFSL QPVDSNSEVQ
160 170 180 190 200
GKVHLELKLN ELITENGTVC QQLVVHIKAC HGLPLINGQS CDPYATVSLV
210 220 230 240 250
GPSRNDQKKT KVKKKTSNPQ FNEIFYFEVT RSSSYTRKSQ FQVEEEDIEK
260 270 280 290 300
LEIRIDLWNN GNLVQDVFLG EIKVPVNVLR TDSSHQAWYL LQPRDNGNKS
310 320 330 340 350
SKTDDLGSLR LNICYTEDYV LPSEYYGPLK TLLLKSPDVQ PISASAAYIL
360 370 380 390 400
SEICRDKNDA VLPLVRLLLH HDKLVPFATA VAELDLKDTQ DANTIFRGNS
410 420 430 440 450
LATRCLDEMM KIVGGHYLKV TLKPILDEIC DSSKSCEIDP IKLKEGDNVE
460 470 480 490 500
NNKENLRYYV DKLFNTIVKS SMSCPTVMCD IFYSLRQMAT QRFPNDPHVQ
510 520 530 540 550
YSAVSSFVFL RFFAVAVVSP HTFHLRPHHP DAQTIRTLTL ISKTIQTLGS
560 570 580 590 600
WGSLSKSKSS FKETFMCEFF KMFQEEGYII AVKKFLDEIS STETKESSGT
610 620 630 640 650
SEPVHLKEGE MYKRAQGRTR IGKKNFKKRW FCLTSRELTY HKQPGSKDAI
660 670 680 690 700
YTIPVKNILA VEKLEESSFN KKNMFQVIHT EKPLYVQANN CVEANEWIDV
710 720 730 740 750
LCRVSRCNQN RLSFYHPSVY LNGNWLCCQE TGENTLGCKP CTAGVPADIQ
760 770 780 790 800
IDIDEDRETE RIYSLFTLSL LKLQKMEEAC GTIAVYQGPQ KEPDDYSNFV
810 820 830 840 850
IEDSVTTFKT IQQIKSIIEK LDEPHEKYRK KRSSSAKYGS KENPIVGKAS
Length:850
Mass (Da):96,614
Last modified:June 26, 2013 - v3
Checksum:i1F357940CA106E5E
GO
Isoform 2 (identifier: Q15283-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     646-646: Missing.

Show »
Length:849
Mass (Da):96,527
Checksum:iA4B491DFF5C4CB76
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti216T → A in BAA11230 (PubMed:8917095).Curated1
Sequence conflicti225F → S in BAF84705 (PubMed:14702039).Curated1
Sequence conflicti645G → EFIER in BAA11621 (PubMed:8812506).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_046545646Missing in isoform 2. 2 Publications1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78155 mRNA Translation: BAA11230.1
D78156 Genomic DNA Translation: BAA11231.1
D82880 mRNA Translation: BAA11621.1
D82881 Genomic DNA Translation: BAA11622.1
AF115573 mRNA Translation: AAD09821.1
AC010184 Genomic DNA No translation available.
AC092977 Genomic DNA No translation available.
CH471052 Genomic DNA Translation: EAW78999.1
AK292016 mRNA Translation: BAF84705.1
CCDSiCCDS3117.1 [Q15283-2]
PIRiJC5047
RefSeqiNP_001290174.1, NM_001303245.1 [Q15283-1]
NP_001290175.1, NM_001303246.1
NP_006497.2, NM_006506.3 [Q15283-2]
UniGeneiHs.655941
Hs.98445

Genome annotation databases

EnsembliENST00000286364; ENSP00000286364; ENSG00000155903 [Q15283-2]
GeneIDi5922
KEGGihsa:5922
UCSCiuc003etz.2 human [Q15283-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiRASA2_HUMAN
AccessioniPrimary (citable) accession number: Q15283
Secondary accession number(s): A8K7K1
, G3V0F9, O00695, Q15284, Q92594, Q99577, Q9UEQ2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 4, 2001
Last sequence update: June 26, 2013
Last modified: June 20, 2018
This is version 158 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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