Ras GTPase-activating protein 2 - Homo sapiens (Human)

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Q15283 (RASA2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 113. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

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Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Ras GTPase-activating protein 2

Alternative name(s):
GAP1m

Gene names

Name:	RASA2
Synonyms:	GAP1M, RASGAP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	849 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function

Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).

Subcellular location

Cytoplasm. Cytoplasm › perinuclear region.

Sequence similarities

Contains 1 Btk-type zinc finger.

Contains 2 C2 domains.

Contains 1 PH domain.

Contains 1 Ras-GAP domain.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Repeat Zinc-finger
Ligand	Metal-binding Zinc
Molecular function	GTPase activation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	intracellular signal transduction Inferred from electronic annotation. Source: InterPro negative regulation of Ras protein signal transduction Inferred from Biological aspect of Ancestor. Source: RefGenome signal transduction Traceable author statement PubMed 8699317 Ref.2. Source: ProtInc
Cellular_component	cytoplasm Inferred from Biological aspect of Ancestor. Source: RefGenome intracellular membrane-bounded organelle Inferred from direct assay. Source: HPA intrinsic to internal side of plasma membrane Inferred from Biological aspect of Ancestor. Source: RefGenome perinuclear region of cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	Ras GTPase activator activity Inferred from Biological aspect of Ancestor. Source: RefGenome metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW phospholipid binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 849

849

Ras GTPase-activating protein 2

PRO_0000056638

Regions

Domain

25 – 122

C2 1

Domain

158 – 273

116

C2 2

Domain

356 – 550

195

Ras-GAP

Domain

604 – 705

102

Zinc finger

707 – 743

Btk-type

Compositional bias

2 – 26

Ala-rich

Experimental info

Sequence conflict

216

T → A in BAA11230. Ref.1

Sequence conflict

645

G → EFIER in BAA11621. Ref.2

Sequence conflict

645

G → GS in BAA11230. Ref.1

Sequence conflict

645

G → GS in BAA11231. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q15283 [UniParc].

Last modified May 4, 2001. Version 2.
Checksum: A4B491DFF5C4CB76
Show »

FASTA

849

96,527

        10         20         30         40         50         60 
MAAAAPAAAA ASSEAPAASA TAEPEAGDQD SREVRVLQSL RGKICEAKNL LPYLGPHKMR 

        70         80         90        100        110        120 
DCFCTINLDQ EEVYRTQVVE KSLSPFFSEE FYFEIPRTFQ YLSFYVYDKN VLQRDLRIGK 

       130        140        150        160        170        180 
VAIKKEDLCN HSGKETWFSL QPVDSNSEVQ GKVHLELKLN ELITENGTVC QQLVVHIKAC 

       190        200        210        220        230        240 
HGLPLINGQS CDPYATVSLV GPSRNDQKKT KVKKKTSNPQ FNEIFYFEVT RSSSYTRKSQ 

       250        260        270        280        290        300 
FQVEEEDIEK LEIRIDLWNN GNLVQDVFLG EIKVPVNVLR TDSSHQAWYL LQPRDNGNKS 

       310        320        330        340        350        360 
SKTDDLGSLR LNICYTEDYV LPSEYYGPLK TLLLKSPDVQ PISASAAYIL SEICRDKNDA 

       370        380        390        400        410        420 
VLPLVRLLLH HDKLVPFATA VAELDLKDTQ DANTIFRGNS LATRCLDEMM KIVGGHYLKV 

       430        440        450        460        470        480 
TLKPILDEIC DSSKSCEIDP IKLKEGDNVE NNKENLRYYV DKLFNTIVKS SMSCPTVMCD 

       490        500        510        520        530        540 
IFYSLRQMAT QRFPNDPHVQ YSAVSSFVFL RFFAVAVVSP HTFHLRPHHP DAQTIRTLTL 

       550        560        570        580        590        600 
ISKTIQTLGS WGSLSKSKSS FKETFMCEFF KMFQEEGYII AVKKFLDEIS STETKESSGT 

       610        620        630        640        650        660 
SEPVHLKEGE MYKRAQGRTR IGKKNFKKRW FCLTSRELTY HKQPGKDAIY TIPVKNILAV 

       670        680        690        700        710        720 
EKLEESSFNK KNMFQVIHTE KPLYVQANNC VEANEWIDVL CRVSRCNQNR LSFYHPSVYL 

       730        740        750        760        770        780 
NGNWLCCQET GENTLGCKPC TAGVPADIQI DIDEDRETER IYSLFTLSLL KLQKMEEACG 

       790        800        810        820        830        840 
TIAVYQGPQK EPDDYSNFVI EDSVTTFKTI QQIKSIIEKL DEPHEKYRKK RSSSAKYGSK 


ENPIVGKAS

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References

[1]	"Human rasGTPase-activating protein (human counterpart of GAP1m): sequence of the cDNA, primary structure of the protein, production and chromosomal localization." Kobayashi M., Masui T., Kusuda J., Kameoka Y., Hashimoto K., Iwashita S. Gene 175:173-177(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
[2]	"cDNA cloning and chromosomal mapping of a novel human GAP (GAP1M), a GTPase-activating protein of Ras." Li S., Satoh H., Watanabe T., Nakamura S., Hattori S. Genomics 35:625-627(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]. Tissue: Brain.
[3]	"Distinct subcellular localisations of the putative inositol 1,3,4,5-tetrakisphosphate receptors GAP1(IP4BP) and GAP1m result from the GAP1(IP4BP) PH domain directing plasma membrane targeting." Lockyer P.J., Bottomley J.R., Reynolds J.S., McNulty T.J., Venkateswarlu K., Potter B.V.L., Dempsey C.E., Cullen P.J. Curr. Biol. 7:1007-1010(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Blood.
[4]	Lockyer P.J. Submitted (DEC-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE. Tissue: Blood.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D78155 mRNA. Translation: BAA11230.1. D78156 Genomic DNA. Translation: BAA11231.1. D82880 mRNA. Translation: BAA11621.1. D82881 Genomic DNA. Translation: BAA11622.1. AF115573 mRNA. Translation: AAD09821.1.
IPI	IPI00015811.
PIR	JC5047.
RefSeq	NP_006497.2. NM_006506.2.
UniGene	Hs.655941.
3D structure databases
ProteinModelPortal	Q15283.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000286364.
PTM databases
PhosphoSite	Q15283.
Polymorphism databases
DMDM	13959563.
Proteomic databases
PaxDb	Q15283.
PRIDE	Q15283.
Protocols and materials databases
DNASU	5922.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000286364; ENSP00000286364; ENSG00000155903.
GeneID	5922.
KEGG	hsa:5922.
UCSC	uc003etz.1. human.
Organism-specific databases
CTD	5922.
GeneCards	GC03P141205.
HGNC	HGNC:9872. RASA2.
HPA	HPA035374.
MIM	601589. gene.
neXtProt	NX_Q15283.
PharmGKB	PA34233.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG323905.
HOGENOM	HOG000007183.
HOVERGEN	HBG055643.
InParanoid	Q15283.
KO	K08053.
OrthoDB	EOG4MSCXJ.
PhylomeDB	Q15283.
Gene expression databases
ArrayExpress	Q15283.
Bgee	Q15283.
CleanEx	HS_RASA2.
Genevestigator	Q15283.
Family and domain databases
Gene3D	1.10.506.10. 1 hit. 2.30.29.30. 1 hit.
InterPro	IPR000008. C2_Ca-dep. IPR008973. C2_Ca/lipid-bd_dom_CaLB. IPR018029. C2_membr_targeting. IPR011993. PH_like_dom. IPR001849. Pleckstrin_homology. IPR001936. RasGAP. IPR023152. RasGAP_CS. IPR008936. Rho_GTPase_activation_prot. IPR001562. Znf_Btk_motif. [Graphical view]
Pfam	PF00779. BTK. 1 hit. PF00168. C2. 2 hits. PF00169. PH. 1 hit. PF00616. RasGAP. 1 hit. [Graphical view]
PRINTS	PR00402. TECBTKDOMAIN.
SMART	SM00107. BTK. 1 hit. SM00239. C2. 2 hits. SM00233. PH. 1 hit. SM00323. RasGAP. 1 hit. [Graphical view]
SUPFAM	SSF49562. C2_CaLB. 2 hits. SSF48350. Rho_GAP. 1 hit.
PROSITE	PS50004. C2. 2 hits. PS50003. PH_DOMAIN. 1 hit. PS00509. RAS_GTPASE_ACTIV_1. 1 hit. PS50018. RAS_GTPASE_ACTIV_2. 1 hit. PS51113. ZF_BTK. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5922.
NextBio	23062.
SOURCE	Search...

Entry information

Entry name

RASA2_HUMAN

Accession

Primary (citable) accession number: Q15283
Secondary accession number(s): O00695

Q9UEQ2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 4, 2001
Last sequence update:	May 4, 2001
Last modified:	May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents