ID   NKX11_HUMAN             Reviewed;         448 AA.
AC   Q15270;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   23-FEB-2022, sequence version 3.
DT   24-JAN-2024, entry version 158.
DE   RecName: Full=NK1 transcription factor-related protein 1 {ECO:0000305};
DE   AltName: Full=Homeobox protein 153;
DE            Short=HPX-153 {ECO:0000303|PubMed:7518789};
DE   AltName: Full=Homeobox protein SAX-2;
DE   AltName: Full=NKX-1.1;
GN   Name=NKX1-1 {ECO:0000312|HGNC:HGNC:24975};
GN   Synonyms=HPX153 {ECO:0000303|PubMed:7518789}, SAX2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15815621; DOI=10.1038/nature03466;
RA   Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA   Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA   Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA   Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA   Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA   Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA   Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA   Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA   Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA   McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA   Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA   Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA   Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA   Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA   Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA   Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA   Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA   Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA   Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA   Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA   Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA   Wilson R.K.;
RT   "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT   4.";
RL   Nature 434:724-731(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 304-342, AND TISSUE SPECIFICITY.
RC   TISSUE=Bone marrow;
RX   PubMed=7518789; DOI=10.1016/0378-1119(94)90380-8;
RA   Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M.,
RA   D'Andrea R.;
RT   "Identification of homeobox genes expressed in human haemopoietic
RT   progenitor cells.";
RL   Gene 144:213-219(1994).
CC   -!- FUNCTION: May be required for the coordinated crosstalk of factors
CC       involved in the maintenance of energy homeostasis, possibly by
CC       regulating the transcription of specific factors involved in energy
CC       balance. {ECO:0000250|UniProtKB:G3UXB3}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- TISSUE SPECIFICITY: Expressed in hemopoietic progenitor cells.
CC       {ECO:0000269|PubMed:7518789}.
CC   -!- SIMILARITY: Belongs to the NK-1 homeobox family. {ECO:0000305}.
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DR   EMBL; AC118281; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; X76978; CAA54282.1; -; mRNA.
DR   CCDS; CCDS93464.1; -.
DR   PIR; I38143; I38143.
DR   RefSeq; NP_001277008.1; NM_001290079.1.
DR   AlphaFoldDB; Q15270; -.
DR   SMR; Q15270; -.
DR   IntAct; Q15270; 1.
DR   STRING; 9606.ENSP00000407978; -.
DR   PhosphoSitePlus; Q15270; -.
DR   BioMuta; NKX1-1; -.
DR   DMDM; 189029591; -.
DR   MassIVE; Q15270; -.
DR   PaxDb; 9606-ENSP00000407978; -.
DR   PeptideAtlas; Q15270; -.
DR   ProteomicsDB; 60507; -.
DR   Antibodypedia; 22251; 97 antibodies from 12 providers.
DR   Ensembl; ENST00000422806.2; ENSP00000407978.2; ENSG00000235608.2.
DR   GeneID; 54729; -.
DR   KEGG; hsa:54729; -.
DR   MANE-Select; ENST00000422806.2; ENSP00000407978.2; NM_001290079.1; NP_001277008.1.
DR   UCSC; uc062ulo.1; human.
DR   AGR; HGNC:24975; -.
DR   CTD; 54729; -.
DR   GeneCards; NKX1-1; -.
DR   HGNC; HGNC:24975; NKX1-1.
DR   HPA; ENSG00000235608; Not detected.
DR   MIM; 617869; gene.
DR   neXtProt; NX_Q15270; -.
DR   PharmGKB; PA145148380; -.
DR   VEuPathDB; HostDB:ENSG00000235608; -.
DR   eggNOG; KOG0488; Eukaryota.
DR   GeneTree; ENSGT00940000162861; -.
DR   HOGENOM; CLU_063378_1_0_1; -.
DR   InParanoid; Q15270; -.
DR   OMA; NDTNGYS; -.
DR   PhylomeDB; Q15270; -.
DR   TreeFam; TF316128; -.
DR   PathwayCommons; Q15270; -.
DR   SignaLink; Q15270; -.
DR   Pharos; Q15270; Tdark.
DR   PRO; PR:Q15270; -.
DR   Proteomes; UP000005640; Chromosome 4.
DR   RNAct; Q15270; Protein.
DR   Bgee; ENSG00000235608; Expressed in left testis and 2 other cell types or tissues.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0030154; P:cell differentiation; IBA:GO_Central.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR24340; HOMEOBOX PROTEIN NKX; 1.
DR   PANTHER; PTHR24340:SF26; NK1 TRANSCRIPTION FACTOR-RELATED PROTEIN 1; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; Q15270; HS.
PE   2: Evidence at transcript level;
KW   DNA-binding; Homeobox; Nucleus; Reference proteome.
FT   CHAIN           1..448
FT                   /note="NK1 transcription factor-related protein 1"
FT                   /id="PRO_0000333009"
FT   DNA_BIND        296..355
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..80
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          115..299
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          350..397
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        10..28
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        167..181
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..205
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        283..299
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        331
FT                   /note="L -> V (in Ref. 2; CAA54282)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   448 AA;  44012 MW;  1DA2864CAF0746AC CRC64;
     MSASGPEAPG DIPALPPPPQ PGSGPAPPAP AAAAQEAMDG RAELPAFPRA GAPPLAASDT
     VPAAPEGAGA ARPAAPLRPT SFSVLDILDP NKFNSRRRRC VLLGPVAPAA CAPCASAPCA
     PAPAASGRPP RAEELERRAL AGAGGVGAAG AEPPNAGDPF KAGEAETNDT NGYSSGGGGH
     SPSADSGDEV PDDEDDDEDE APETEAARGA EEARGGGGGL GARGSGCQGA AETDASPGAT
     VDEAAAPGPR ENSPVAQGPP GGAAAPGGAG TTPQGTATAA KPKRKRTGSD SKSGKPRRAR
     TAFTYEQLVA LENKFKATRY LSVCERLNLA LSLSLTETQV KIWFQNRRTK WKKQNPGADT
     SAPTGGGGGP GPGAGPGTGL PGGLSPLSPS PPMGAPLGMH GPAGYPAHGP GGLVCAAQLP
     FLSSPAVLSP FVLGSQTYGA PAFYAPHL
//