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Q15270

- NKX11_HUMAN

UniProt

Q15270 - NKX11_HUMAN

Protein

NK1 transcription factor-related protein 1

Gene

NKX1-1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 96 (01 Oct 2014)
      Sequence version 2 (20 May 2008)
      Previous versions | rss
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    Functioni

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi259 – 31860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. lipid metabolic process Source: Ensembl
    2. neurological system process Source: Ensembl
    3. regulation of generation of precursor metabolites and energy Source: Ensembl
    4. regulation of glucose metabolic process Source: Ensembl

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NK1 transcription factor-related protein 1
    Alternative name(s):
    Homeobox protein 153
    Short name:
    HPX-153
    Homeobox protein SAX-2
    NKX-1.1
    Gene namesi
    Name:NKX1-1
    Synonyms:HPX153
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:24975. NKX1-1.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA145148380.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 411411NK1 transcription factor-related protein 1PRO_0000333009Add
    BLAST

    Proteomic databases

    PaxDbiQ15270.
    PRIDEiQ15270.

    PTM databases

    PhosphoSiteiQ15270.

    Expressioni

    Tissue specificityi

    Expressed in hemopoietic progenitor cells.1 Publication

    Gene expression databases

    BgeeiQ15270.
    CleanExiHS_NKX1-1.
    GenevestigatoriQ15270.

    Organism-specific databases

    HPAiHPA029367.

    Interactioni

    Protein-protein interaction databases

    IntActiQ15270. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15270.
    SMRiQ15270. Positions 260-316.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi59 – 624Poly-Arg
    Compositional biasi105 – 238134Gly-richAdd
    BLAST
    Compositional biasi328 – 37548Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the NK-1 homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG286158.
    HOGENOMiHOG000203703.
    OMAiNKFNSRR.
    OrthoDBiEOG7R2BM5.
    TreeFamiTF316128.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15270-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGRAELPAF PRAGAPPLAA SDTVPAAPEG AGAARPAAPL RPTSFSVLDI    50
    LDPNKFNSRR RRCVLLGPVA PAACAPCASA PCAPAPAASG RPPRAEELER 100
    RALAGAGGVG AAGAEPPNAG DPFKAGEAET NDTNGYSSGG GGHSPSADSG 150
    DEVPDDEDDD EDEAPETEAA RGAEEARGGG GGLGARGSGC QGAAETDASP 200
    GATVDEAAAP GPRENSPVAQ GPPGGAAAPG GAGTTPQGTA TAAKPKRKRT 250
    GSDSKSGKPR RARTAFTYEQ LVALENKFKA TRYLSVCERL NLALSLSLTE 300
    TQVKIWFQNR RTKWKKQNPG ADTSAPTGGG GGPGPGAGPG TGLPGGLSPL 350
    SPSPPMGAPL GMHGPAGYPA HGPGGLVCAA QLPFLSSPAV LSPFVLGSQT 400
    YGAPAFYAPH L 411
    Length:411
    Mass (Da):40,659
    Last modified:May 20, 2008 - v2
    Checksum:iF99A130A98726769
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti294 – 2941L → V in CAA54282. (PubMed:7518789)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC118281 Genomic DNA. No translation available.
    X76978 mRNA. Translation: CAA54282.1.
    PIRiI38143.
    UniGeneiHs.526396.

    Genome annotation databases

    EnsembliENST00000422806; ENSP00000407978; ENSG00000235608.

    Polymorphism databases

    DMDMi189029591.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC118281 Genomic DNA. No translation available.
    X76978 mRNA. Translation: CAA54282.1 .
    PIRi I38143.
    UniGenei Hs.526396.

    3D structure databases

    ProteinModelPortali Q15270.
    SMRi Q15270. Positions 260-316.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q15270. 1 interaction.

    PTM databases

    PhosphoSitei Q15270.

    Polymorphism databases

    DMDMi 189029591.

    Proteomic databases

    PaxDbi Q15270.
    PRIDEi Q15270.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000422806 ; ENSP00000407978 ; ENSG00000235608 .

    Organism-specific databases

    GeneCardsi GC04M001380.
    H-InvDB HIX0031928.
    HGNCi HGNC:24975. NKX1-1.
    HPAi HPA029367.
    neXtProti NX_Q15270.
    PharmGKBi PA145148380.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG286158.
    HOGENOMi HOG000203703.
    OMAi NKFNSRR.
    OrthoDBi EOG7R2BM5.
    TreeFami TF316128.

    Miscellaneous databases

    NextBioi 13611226.
    PROi Q15270.

    Gene expression databases

    Bgeei Q15270.
    CleanExi HS_NKX1-1.
    Genevestigatori Q15270.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
      , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
      Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    2. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."
      Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
      Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 267-305, TISSUE SPECIFICITY.
      Tissue: Bone marrow.

    Entry informationi

    Entry nameiNKX11_HUMAN
    AccessioniPrimary (citable) accession number: Q15270
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: May 20, 2008
    Last modified: October 1, 2014
    This is version 96 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3