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Protein

NK1 transcription factor-related protein 1

Gene

NKX1-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi259 – 318HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NK1 transcription factor-related protein 1
Alternative name(s):
Homeobox protein 153
Short name:
HPX-153
Homeobox protein SAX-2
NKX-1.1
Gene namesi
Name:NKX1-1
Synonyms:HPX153
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000235608.1
HGNCiHGNC:24975 NKX1-1
MIMi617869 gene
neXtProtiNX_Q15270

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54729
PharmGKBiPA145148380

Polymorphism and mutation databases

DMDMi189029591

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330091 – 411NK1 transcription factor-related protein 1Add BLAST411

Proteomic databases

PaxDbiQ15270
PeptideAtlasiQ15270
PRIDEiQ15270

PTM databases

PhosphoSitePlusiQ15270

Expressioni

Tissue specificityi

Expressed in hemopoietic progenitor cells.1 Publication

Gene expression databases

BgeeiENSG00000235608
CleanExiHS_NKX1-1
GenevisibleiQ15270 HS

Organism-specific databases

HPAiHPA029367

Interactioni

Protein-protein interaction databases

IntActiQ15270, 1 interactor

Structurei

3D structure databases

ProteinModelPortaliQ15270
SMRiQ15270
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 62Poly-Arg4
Compositional biasi105 – 238Gly-richAdd BLAST134
Compositional biasi328 – 375Gly-richAdd BLAST48

Sequence similaritiesi

Belongs to the NK-1 homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488 Eukaryota
ENOG411188D LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000203703
InParanoidiQ15270
OMAiPATCAPC
OrthoDBiEOG091G0SCQ
TreeFamiTF316128

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q15270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGRAELPAF PRAGAPPLAA SDTVPAAPEG AGAARPAAPL RPTSFSVLDI
60 70 80 90 100
LDPNKFNSRR RRCVLLGPVA PAACAPCASA PCAPAPAASG RPPRAEELER
110 120 130 140 150
RALAGAGGVG AAGAEPPNAG DPFKAGEAET NDTNGYSSGG GGHSPSADSG
160 170 180 190 200
DEVPDDEDDD EDEAPETEAA RGAEEARGGG GGLGARGSGC QGAAETDASP
210 220 230 240 250
GATVDEAAAP GPRENSPVAQ GPPGGAAAPG GAGTTPQGTA TAAKPKRKRT
260 270 280 290 300
GSDSKSGKPR RARTAFTYEQ LVALENKFKA TRYLSVCERL NLALSLSLTE
310 320 330 340 350
TQVKIWFQNR RTKWKKQNPG ADTSAPTGGG GGPGPGAGPG TGLPGGLSPL
360 370 380 390 400
SPSPPMGAPL GMHGPAGYPA HGPGGLVCAA QLPFLSSPAV LSPFVLGSQT
410
YGAPAFYAPH L
Length:411
Mass (Da):40,659
Last modified:May 20, 2008 - v2
Checksum:iF99A130A98726769
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti294L → V in CAA54282 (PubMed:7518789).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118281 Genomic DNA No translation available.
X76978 mRNA Translation: CAA54282.1
PIRiI38143
UniGeneiHs.526396

Genome annotation databases

EnsembliENST00000422806; ENSP00000407978; ENSG00000235608
UCSCiuc062ulo.1 human

Similar proteinsi

Entry informationi

Entry nameiNKX11_HUMAN
AccessioniPrimary (citable) accession number: Q15270
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: May 23, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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