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Protein

NK1 transcription factor-related protein 1

Gene

NKX1-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi259 – 318HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:G66-32914-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NK1 transcription factor-related protein 1
Alternative name(s):
Homeobox protein 153
Short name:
HPX-153
Homeobox protein SAX-2
NKX-1.1
Gene namesi
Name:NKX1-1
Synonyms:HPX153
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24975. NKX1-1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi54729.
OpenTargetsiENSG00000235608.
PharmGKBiPA145148380.

Polymorphism and mutation databases

DMDMi189029591.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003330091 – 411NK1 transcription factor-related protein 1Add BLAST411

Proteomic databases

PaxDbiQ15270.
PeptideAtlasiQ15270.
PRIDEiQ15270.

PTM databases

PhosphoSitePlusiQ15270.

Expressioni

Tissue specificityi

Expressed in hemopoietic progenitor cells.1 Publication

Gene expression databases

BgeeiENSG00000235608.
CleanExiHS_NKX1-1.
GenevisibleiQ15270. HS.

Organism-specific databases

HPAiHPA029367.

Interactioni

Protein-protein interaction databases

IntActiQ15270. 1 interactor.
STRINGi9606.ENSP00000407978.

Structurei

3D structure databases

ProteinModelPortaliQ15270.
SMRiQ15270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi59 – 62Poly-Arg4
Compositional biasi105 – 238Gly-richAdd BLAST134
Compositional biasi328 – 375Gly-richAdd BLAST48

Sequence similaritiesi

Belongs to the NK-1 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00850000132268.
HOGENOMiHOG000203703.
InParanoidiQ15270.
OMAiEPPNAGD.
OrthoDBiEOG091G0SCQ.
TreeFamiTF316128.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGRAELPAF PRAGAPPLAA SDTVPAAPEG AGAARPAAPL RPTSFSVLDI
60 70 80 90 100
LDPNKFNSRR RRCVLLGPVA PAACAPCASA PCAPAPAASG RPPRAEELER
110 120 130 140 150
RALAGAGGVG AAGAEPPNAG DPFKAGEAET NDTNGYSSGG GGHSPSADSG
160 170 180 190 200
DEVPDDEDDD EDEAPETEAA RGAEEARGGG GGLGARGSGC QGAAETDASP
210 220 230 240 250
GATVDEAAAP GPRENSPVAQ GPPGGAAAPG GAGTTPQGTA TAAKPKRKRT
260 270 280 290 300
GSDSKSGKPR RARTAFTYEQ LVALENKFKA TRYLSVCERL NLALSLSLTE
310 320 330 340 350
TQVKIWFQNR RTKWKKQNPG ADTSAPTGGG GGPGPGAGPG TGLPGGLSPL
360 370 380 390 400
SPSPPMGAPL GMHGPAGYPA HGPGGLVCAA QLPFLSSPAV LSPFVLGSQT
410
YGAPAFYAPH L
Length:411
Mass (Da):40,659
Last modified:May 20, 2008 - v2
Checksum:iF99A130A98726769
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti294L → V in CAA54282 (PubMed:7518789).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118281 Genomic DNA. No translation available.
X76978 mRNA. Translation: CAA54282.1.
PIRiI38143.
UniGeneiHs.526396.

Genome annotation databases

EnsembliENST00000422806; ENSP00000407978; ENSG00000235608.
UCSCiuc062ulo.1. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118281 Genomic DNA. No translation available.
X76978 mRNA. Translation: CAA54282.1.
PIRiI38143.
UniGeneiHs.526396.

3D structure databases

ProteinModelPortaliQ15270.
SMRiQ15270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ15270. 1 interactor.
STRINGi9606.ENSP00000407978.

PTM databases

PhosphoSitePlusiQ15270.

Polymorphism and mutation databases

DMDMi189029591.

Proteomic databases

PaxDbiQ15270.
PeptideAtlasiQ15270.
PRIDEiQ15270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422806; ENSP00000407978; ENSG00000235608.
UCSCiuc062ulo.1. human.

Organism-specific databases

DisGeNETi54729.
GeneCardsiNKX1-1.
H-InvDBHIX0031928.
HGNCiHGNC:24975. NKX1-1.
HPAiHPA029367.
neXtProtiNX_Q15270.
OpenTargetsiENSG00000235608.
PharmGKBiPA145148380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0488. Eukaryota.
ENOG411188D. LUCA.
GeneTreeiENSGT00850000132268.
HOGENOMiHOG000203703.
InParanoidiQ15270.
OMAiEPPNAGD.
OrthoDBiEOG091G0SCQ.
TreeFamiTF316128.

Enzyme and pathway databases

BioCyciZFISH:G66-32914-MONOMER.

Miscellaneous databases

PROiQ15270.

Gene expression databases

BgeeiENSG00000235608.
CleanExiHS_NKX1-1.
GenevisibleiQ15270. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNKX11_HUMAN
AccessioniPrimary (citable) accession number: Q15270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: November 30, 2016
This is version 114 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.