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Q15270 (NKX11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NK1 transcription factor-related protein 1
Alternative name(s):
Homeobox protein 153
Short name=HPX-153
Homeobox protein SAX-2
NKX-1.1
Gene names
Name:NKX1-1
Synonyms:HPX153
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length411 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Nucleus By similarity.

Tissue specificity

Expressed in hemopoietic progenitor cells. Ref.2

Sequence similarities

Belongs to the NK-1 homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 411411NK1 transcription factor-related protein 1
PRO_0000333009

Regions

DNA binding259 – 31860Homeobox
Compositional bias59 – 624Poly-Arg
Compositional bias105 – 238134Gly-rich
Compositional bias328 – 37548Gly-rich

Experimental info

Sequence conflict2941L → V in CAA54282. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q15270 [UniParc].

Last modified May 20, 2008. Version 2.
Checksum: F99A130A98726769

FASTA41140,659
        10         20         30         40         50         60 
MDGRAELPAF PRAGAPPLAA SDTVPAAPEG AGAARPAAPL RPTSFSVLDI LDPNKFNSRR 

        70         80         90        100        110        120 
RRCVLLGPVA PAACAPCASA PCAPAPAASG RPPRAEELER RALAGAGGVG AAGAEPPNAG 

       130        140        150        160        170        180 
DPFKAGEAET NDTNGYSSGG GGHSPSADSG DEVPDDEDDD EDEAPETEAA RGAEEARGGG 

       190        200        210        220        230        240 
GGLGARGSGC QGAAETDASP GATVDEAAAP GPRENSPVAQ GPPGGAAAPG GAGTTPQGTA 

       250        260        270        280        290        300 
TAAKPKRKRT GSDSKSGKPR RARTAFTYEQ LVALENKFKA TRYLSVCERL NLALSLSLTE 

       310        320        330        340        350        360 
TQVKIWFQNR RTKWKKQNPG ADTSAPTGGG GGPGPGAGPG TGLPGGLSPL SPSPPMGAPL 

       370        380        390        400        410 
GMHGPAGYPA HGPGGLVCAA QLPFLSSPAV LSPFVLGSQT YGAPAFYAPH L 

« Hide

References

« Hide 'large scale' references
[1]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. expand/collapse author list , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]"Identification of homeobox genes expressed in human haemopoietic progenitor cells."
Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 267-305, TISSUE SPECIFICITY.
Tissue: Bone marrow.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AC118281 Genomic DNA. No translation available.
X76978 mRNA. Translation: CAA54282.1.
PIRI38143.
UniGeneHs.526396.

3D structure databases

ProteinModelPortalQ15270.
SMRQ15270. Positions 260-316.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ15270. 1 interaction.

PTM databases

PhosphoSiteQ15270.

Polymorphism databases

DMDM189029591.

Proteomic databases

PaxDbQ15270.
PRIDEQ15270.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000422806; ENSP00000407978; ENSG00000235608.

Organism-specific databases

GeneCardsGC04M001380.
H-InvDBHIX0031928.
HGNCHGNC:24975. NKX1-1.
HPAHPA029367.
neXtProtNX_Q15270.
PharmGKBPA145148380.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG286158.
HOGENOMHOG000203703.
OMANKFNSRR.
OrthoDBEOG7R2BM5.
TreeFamTF316128.

Gene expression databases

BgeeQ15270.
CleanExHS_NKX1-1.
GenevestigatorQ15270.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio13611226.
PROQ15270.

Entry information

Entry nameNKX11_HUMAN
AccessionPrimary (citable) accession number: Q15270
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: March 19, 2014
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM