Q15270 (NKX11_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
NK1 transcription factor-related protein 1

Alternative name(s):
Homeobox protein 153
Short name=HPX-153
Homeobox protein SAX-2
NKX-1.1

Gene names

Name:	NKX1-1
Synonyms:	HPX153

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	411 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Nucleus By similarity.
Tissue specificity	Expressed in hemopoietic progenitor cells. Ref.2
Sequence similarities	Belongs to the NK-1 homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neurological system process Inferred from electronic annotation. Source: Compara regulation of generation of precursor metabolites and energy Inferred from electronic annotation. Source: Compara
Cellular_component	nucleus Non-traceable author statement. Source: UniProtKB
Molecular_function	DNA binding Non-traceable author statement. Source: UniProtKB sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 411	411	NK1 transcription factor-related protein 1		PRO_0000333009
Regions
	DNA binding	259 – 318	60	Homeobox
	Compositional bias	59 – 62	4	Poly-Arg
	Compositional bias	105 – 238	134	Gly-rich
	Compositional bias	328 – 375	48	Gly-rich
Experimental info
	Sequence conflict	294	1	L → V in CAA54282. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q15270 [UniParc]. Last modified May 20, 2008. Version 2. Checksum: F99A130A98726769	FASTA	411	40,659
	10 20 30 40 50 60 MDGRAELPAF PRAGAPPLAA SDTVPAAPEG AGAARPAAPL RPTSFSVLDI LDPNKFNSRR 70 80 90 100 110 120 RRCVLLGPVA PAACAPCASA PCAPAPAASG RPPRAEELER RALAGAGGVG AAGAEPPNAG 130 140 150 160 170 180 DPFKAGEAET NDTNGYSSGG GGHSPSADSG DEVPDDEDDD EDEAPETEAA RGAEEARGGG 190 200 210 220 230 240 GGLGARGSGC QGAAETDASP GATVDEAAAP GPRENSPVAQ GPPGGAAAPG GAGTTPQGTA 250 260 270 280 290 300 TAAKPKRKRT GSDSKSGKPR RARTAFTYEQ LVALENKFKA TRYLSVCERL NLALSLSLTE 310 320 330 340 350 360 TQVKIWFQNR RTKWKKQNPG ADTSAPTGGG GGPGPGAGPG TGLPGGLSPL SPSPPMGAPL 370 380 390 400 410 GMHGPAGYPA HGPGGLVCAA QLPFLSSPAV LSPFVLGSQT YGAPAFYAPH L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[2]	"Identification of homeobox genes expressed in human haemopoietic progenitor cells." Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R. Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 267-305, TISSUE SPECIFICITY. Tissue: Bone marrow.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC118281 Genomic DNA. No translation available. X76978 mRNA. Translation: CAA54282.1.
IPI	IPI00015783.
PIR	I38143.
UniGene	Hs.526396.
3D structure databases
ProteinModelPortal	Q15270.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15270. 1 interaction.
PTM databases
PhosphoSite	Q15270.
Polymorphism databases
DMDM	189029591.
Proteomic databases
PaxDb	Q15270.
PRIDE	Q15270.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000422806; ENSP00000407978; ENSG00000235608.
Organism-specific databases
GeneCards	GC04M001380.
H-InvDB	HIX0031928.
HGNC	HGNC:24975. NKX1-1.
HPA	HPA029367.
neXtProt	NX_Q15270.
PharmGKB	PA145148380.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG286158.
HOGENOM	HOG000203703.
OMA	PATCAPC.
Gene expression databases
Bgee	Q15270.
CleanEx	HS_NKX1-1.
Genevestigator	Q15270.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	13611226.

Entry information

Entry name

NKX11_HUMAN

Accession

Primary (citable) accession number: Q15270

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	May 20, 2008
Last modified:	May 1, 2013
This is version 88 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.