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Protein

NK1 transcription factor-related protein 1

Gene

NKX1-1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi259 – 31860HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NK1 transcription factor-related protein 1
Alternative name(s):
Homeobox protein 153
Short name:
HPX-153
Homeobox protein SAX-2
NKX-1.1
Gene namesi
Name:NKX1-1
Synonyms:HPX153
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:24975. NKX1-1.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA145148380.

Polymorphism and mutation databases

DMDMi189029591.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 411411NK1 transcription factor-related protein 1PRO_0000333009Add
BLAST

Proteomic databases

PaxDbiQ15270.
PRIDEiQ15270.

PTM databases

PhosphoSiteiQ15270.

Expressioni

Tissue specificityi

Expressed in hemopoietic progenitor cells.1 Publication

Gene expression databases

BgeeiQ15270.
CleanExiHS_NKX1-1.

Organism-specific databases

HPAiHPA029367.

Interactioni

Protein-protein interaction databases

IntActiQ15270. 1 interaction.
STRINGi9606.ENSP00000407978.

Structurei

3D structure databases

ProteinModelPortaliQ15270.
SMRiQ15270. Positions 260-316.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi59 – 624Poly-Arg
Compositional biasi105 – 238134Gly-richAdd
BLAST
Compositional biasi328 – 37548Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the NK-1 homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG286158.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000203703.
InParanoidiQ15270.
OMAiNKFNSRR.
OrthoDBiEOG7R2BM5.
TreeFamiTF316128.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15270-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGRAELPAF PRAGAPPLAA SDTVPAAPEG AGAARPAAPL RPTSFSVLDI
60 70 80 90 100
LDPNKFNSRR RRCVLLGPVA PAACAPCASA PCAPAPAASG RPPRAEELER
110 120 130 140 150
RALAGAGGVG AAGAEPPNAG DPFKAGEAET NDTNGYSSGG GGHSPSADSG
160 170 180 190 200
DEVPDDEDDD EDEAPETEAA RGAEEARGGG GGLGARGSGC QGAAETDASP
210 220 230 240 250
GATVDEAAAP GPRENSPVAQ GPPGGAAAPG GAGTTPQGTA TAAKPKRKRT
260 270 280 290 300
GSDSKSGKPR RARTAFTYEQ LVALENKFKA TRYLSVCERL NLALSLSLTE
310 320 330 340 350
TQVKIWFQNR RTKWKKQNPG ADTSAPTGGG GGPGPGAGPG TGLPGGLSPL
360 370 380 390 400
SPSPPMGAPL GMHGPAGYPA HGPGGLVCAA QLPFLSSPAV LSPFVLGSQT
410
YGAPAFYAPH L
Length:411
Mass (Da):40,659
Last modified:May 20, 2008 - v2
Checksum:iF99A130A98726769
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti294 – 2941L → V in CAA54282 (PubMed:7518789).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118281 Genomic DNA. No translation available.
X76978 mRNA. Translation: CAA54282.1.
PIRiI38143.
UniGeneiHs.526396.

Genome annotation databases

EnsembliENST00000422806; ENSP00000407978; ENSG00000235608.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC118281 Genomic DNA. No translation available.
X76978 mRNA. Translation: CAA54282.1.
PIRiI38143.
UniGeneiHs.526396.

3D structure databases

ProteinModelPortaliQ15270.
SMRiQ15270. Positions 260-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ15270. 1 interaction.
STRINGi9606.ENSP00000407978.

PTM databases

PhosphoSiteiQ15270.

Polymorphism and mutation databases

DMDMi189029591.

Proteomic databases

PaxDbiQ15270.
PRIDEiQ15270.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000422806; ENSP00000407978; ENSG00000235608.

Organism-specific databases

GeneCardsiGC04M001396.
H-InvDBHIX0031928.
HGNCiHGNC:24975. NKX1-1.
HPAiHPA029367.
neXtProtiNX_Q15270.
PharmGKBiPA145148380.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG286158.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000203703.
InParanoidiQ15270.
OMAiNKFNSRR.
OrthoDBiEOG7R2BM5.
TreeFamiTF316128.

Miscellaneous databases

NextBioi13611226.
PROiQ15270.

Gene expression databases

BgeeiQ15270.
CleanExiHS_NKX1-1.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
    Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H.
    , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K.
    Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "Identification of homeobox genes expressed in human haemopoietic progenitor cells."
    Moretti P., Simmons P., Thomas P., Haylock D., Rathjen P., Vadas M., D'Andrea R.
    Gene 144:213-219(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 267-305, TISSUE SPECIFICITY.
    Tissue: Bone marrow.

Entry informationi

Entry nameiNKX11_HUMAN
AccessioniPrimary (citable) accession number: Q15270
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 20, 2008
Last modified: June 24, 2015
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.