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Q15262

- PTPRK_HUMAN

UniProt

Q15262 - PTPRK_HUMAN

Protein

Receptor-type tyrosine-protein phosphatase kappa

Gene

PTPRK

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 154 (01 Oct 2014)
      Sequence version 2 (01 May 2007)
      Previous versions | rss
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    Functioni

    Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.1 Publication

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei643 – 6442CleavageCurated
    Binding sitei1050 – 10501SubstrateBy similarity
    Active sitei1082 – 10821Phosphocysteine intermediateBy similarity
    Binding sitei1126 – 11261SubstrateBy similarity
    Active sitei1376 – 13761Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. beta-catenin binding Source: UniProtKB
    2. gamma-catenin binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. protein kinase binding Source: UniProtKB
    5. protein tyrosine phosphatase activity Source: UniProtKB
    6. transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB

    GO - Biological processi

    1. cell adhesion Source: UniProtKB
    2. cell migration Source: UniProtKB
    3. cellular response to reactive oxygen species Source: UniProtKB
    4. cellular response to UV Source: UniProtKB
    5. focal adhesion assembly Source: UniProtKB
    6. negative regulation of cell cycle Source: UniProtKB
    7. negative regulation of cell migration Source: UniProtKB
    8. negative regulation of cell proliferation Source: UniProtKB
    9. negative regulation of keratinocyte proliferation Source: UniProtKB
    10. negative regulation of transcription, DNA-templated Source: UniProtKB
    11. neuron projection development Source: Ensembl
    12. protein dephosphorylation Source: UniProtKB
    13. protein localization to cell surface Source: UniProtKB
    14. signal transduction Source: UniProtKB
    15. transforming growth factor beta receptor signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Enzyme and pathway databases

    SignaLinkiQ15262.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase kappa (EC:3.1.3.48)
    Short name:
    Protein-tyrosine phosphatase kappa
    Short name:
    R-PTP-kappa
    Gene namesi
    Name:PTPRK
    Synonyms:PTPK
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:9674. PTPRK.

    Subcellular locationi

    GO - Cellular componenti

    1. adherens junction Source: UniProtKB-SubCell
    2. axon Source: Ensembl
    3. cell-cell junction Source: UniProtKB
    4. cell surface Source: UniProtKB
    5. dendrite Source: Ensembl
    6. integral component of membrane Source: UniProtKB
    7. integral component of plasma membrane Source: UniProtKB
    8. leading edge membrane Source: UniProtKB
    9. neuronal cell body Source: Ensembl
    10. photoreceptor outer segment Source: Ensembl

    Keywords - Cellular componenti

    Cell junction, Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34019.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Chaini27 – 14391413Receptor-type tyrosine-protein phosphatase kappaPRO_0000025446Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi101 – 1011N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi140 – 1401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi211 – 2111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi216 ↔ 270PROSITE-ProRule annotation
    Glycosylationi416 – 4161N-linked (GlcNAc...)2 Publications
    Glycosylationi424 – 4241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi436 – 4361N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi462 – 4621N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi552 – 5521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi586 – 5861N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi590 – 5901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi607 – 6071N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi690 – 6901N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    This protein undergoes proteolytic processing.

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ15262.
    PaxDbiQ15262.
    PRIDEiQ15262.

    PTM databases

    PhosphoSiteiQ15262.

    Expressioni

    Tissue specificityi

    High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.

    Gene expression databases

    ArrayExpressiQ15262.
    BgeeiQ15262.
    CleanExiHS_PTPRK.
    GenevestigatoriQ15262.

    Organism-specific databases

    HPAiHPA054822.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ERBB2P046262EBI-474052,EBI-641062
    LOXP283004EBI-474052,EBI-3893481
    TEKQ027632EBI-474052,EBI-2257090

    Protein-protein interaction databases

    BioGridi111760. 9 interactions.
    IntActiQ15262. 22 interactions.
    MINTiMINT-1350116.
    STRINGi9606.ENSP00000357209.

    Structurei

    Secondary structure

    1
    1439
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi869 – 8713
    Helixi872 – 8798
    Beta strandi883 – 8853
    Helixi887 – 8926
    Helixi903 – 9064
    Helixi908 – 9136
    Helixi923 – 9253
    Helixi936 – 9394
    Beta strandi942 – 9487
    Beta strandi951 – 9588
    Helixi963 – 9653
    Helixi966 – 97611
    Beta strandi980 – 9834
    Beta strandi987 – 9893
    Beta strandi1001 – 10066
    Beta strandi1009 – 101810
    Beta strandi1020 – 103112
    Beta strandi1038 – 10458
    Beta strandi1050 – 10534
    Helixi1058 – 107013
    Beta strandi1078 – 10814
    Beta strandi1083 – 10864
    Helixi1087 – 110519
    Beta strandi1106 – 11083
    Helixi1110 – 112011
    Helixi1128 – 114417
    Turni1150 – 11534

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2C7SX-ray1.95A865-1154[»]
    ProteinModelPortaliQ15262.
    SMRiQ15262. Positions 33-596, 864-1438.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15262.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini27 – 752726ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini775 – 1439665CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei753 – 77422HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini31 – 194164MAMPROSITE-ProRule annotationAdd
    BLAST
    Domaini196 – 28186Ig-like C2-typeAdd
    BLAST
    Domaini294 – 38996Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini392 – 48897Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini491 – 595105Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini597 – 68084Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini887 – 1141255Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini1173 – 1435263Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1082 – 10887Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
    Contains 1 MAM domain.PROSITE-ProRule annotation
    Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000049029.
    HOVERGENiHBG062785.
    KOiK06776.
    OrthoDBiEOG70KGNP.
    PhylomeDBiQ15262.
    TreeFamiTF312900.

    Family and domain databases

    Gene3Di2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR000998. MAM_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view]
    PfamiPF00041. fn3. 2 hits.
    PF00629. MAM. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view]
    PRINTSiPR00020. MAMDOMAIN.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00137. MAM. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEiPS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q15262-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD     50
    LYDDFEWVHV SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE 100
    NDTHCIDFSY LLYSQKGLNP GTLNILVRVN KGPLANPIWN VTGFTGRDWL 150
    RAELAVSTFW PNEYQVIFEA EVSGGRSGYI AIDDIQVLSY PCDKSPHFLR 200
    LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV AQTKNINHRR 250
    FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL 300
    LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL 350
    WHLDPDTEYE IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE 400
    IQARRIAVDW ESLGYNITRC HTFNVTICYH YFRGHNESKA DCLDMDPKAP 450
    QHVVNHLPPY TNVSLKMILT NPEGRKESEE TIIQTDEDVP GPVPVKSLQG 500
    TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV AGPPQTVSNL 550
    WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE 600
    GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME 650
    CYQVPVTYQN AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP 700
    LAPRKGYNIY FQAMSSVEKE TKTQCVRIAT KAATEEPEVI PDPAKQTDRV 750
    VKIAGISAGI LVFILLLLVV ILIVKKSKLA KKRKDAMGNT RQEMTHMVNA 800
    MDRSYADQST LHAEDPLSIT FMDQHNFSPR YENHSATAES SRLLDVPRYL 850
    CEGTESPYQT GQLHPAIRVA DLLQHINLMK TSDSYGFKEE YESFFEGQSA 900
    SWDVAKKDQN RAKNRYGNII AYDHSRVILQ PVEDDPSSDY INANYIDGYQ 950
    RPSHYIATQG PVHETVYDFW RMIWQEQSAC IVMVTNLVEV GRVKCYKYWP 1000
    DDTEVYGDFK VTCVEMEPLA EYVVRTFTLE RRGYNEIREV KQFHFTGWPD 1050
    HGVPYHATGL LSFIRRVKLS NPPSAGPIVV HCSAGAGRTG CYIVIDIMLD 1100
    MAEREGVVDI YNCVKALRSR RINMVQTEEQ YIFIHDAILE ACLCGETAIP 1150
    VCEFKAAYFD MIRIDSQTNS SHLKDEFQTL NSVTPRLQAE DCSIACLPRN 1200
    HDKNRFMDML PPDRCLPFLI TIDGESSNYI NAALMDSYRQ PAAFIVTQYP 1250
    LPNTVKDFWR LVYDYGCTSI VMLNEVDLSQ GCPQYWPEEG MLRYGPIQVE 1300
    CMSCSMDCDV INRIFRICNL TRPQEGYLMV QQFQYLGWAS HREVPGSKRS 1350
    FLKLILQVEK WQEECEEGEG RTIIHCLNGG GRSGMFCAIG IVVEMVKRQN 1400
    VVDVFHAVKT LRNSKPNMVE APEQYRFCYD VALEYLESS 1439
    Length:1,439
    Mass (Da):162,102
    Last modified:May 1, 2007 - v2
    Checksum:iEE1EA6EA3CCA31ED
    GO
    Isoform 2 (identifier: Q15262-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         732-732: A → AA

    Show »
    Length:1,440
    Mass (Da):162,173
    Checksum:i41B5AD638EE63969
    GO
    Isoform 3 (identifier: Q15262-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         732-732: A → AA
         946-946: I → IDIWLYR

    Note: No experimental confirmation available.

    Show »
    Length:1,446
    Mass (Da):163,020
    Checksum:i43919D3BA33C84C4
    GO
    Isoform 4 (identifier: Q15262-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         732-732: A → AA
         831-831: Y → LPNDPLVPTAVLVPITD
         946-946: I → IDIWLYR

    Note: No experimental confirmation available.

    Show »
    Length:1,462
    Mass (Da):164,613
    Checksum:iC3CEA4670A00B758
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti9 – 91L → V in AAC37599. (PubMed:9047348)Curated
    Sequence conflicti158 – 1581T → S in CAA94519. (PubMed:8663237)Curated
    Sequence conflicti284 – 2841A → P in AAC37599. (PubMed:9047348)Curated
    Sequence conflicti422 – 4221T → S in AAC37599. (PubMed:9047348)Curated
    Sequence conflicti672 – 6743AEL → CRT in AAC37599. (PubMed:9047348)Curated
    Sequence conflicti715 – 7151S → T in AAC37599. (PubMed:9047348)Curated
    Sequence conflicti1366 – 13661E → K in AAC37599. (PubMed:9047348)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei732 – 7321A → AA in isoform 2, isoform 3 and isoform 4. 2 PublicationsVSP_024819
    Alternative sequencei831 – 8311Y → LPNDPLVPTAVLVPITD in isoform 4. 1 PublicationVSP_054480
    Alternative sequencei946 – 9461I → IDIWLYR in isoform 3 and isoform 4. 1 PublicationVSP_042049

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70660 mRNA. Translation: CAA94519.1.
    L77886 mRNA. Translation: AAC37599.1.
    AL035470
    , AL034349, AL035465, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI21516.1.
    AL035470
    , AL034349, AL035465, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI21517.1.
    AL034349
    , AL035465, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI23054.1.
    AL034349
    , AL035465, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI23055.1.
    AL590006
    , AL034349, AL035465, AL035470, AL035594, AL357621, AL451073 Genomic DNA. Translation: CAI39438.1.
    AL590006
    , AL034349, AL035465, AL035470, AL035594, AL357621, AL451073 Genomic DNA. Translation: CAI39440.1.
    AL451073
    , AL034349, AL035465, AL035470, AL035594, AL357621, AL590006 Genomic DNA. Translation: CAI40499.1.
    AL451073
    , AL034349, AL035465, AL035470, AL035594, AL357621, AL590006 Genomic DNA. Translation: CAI40501.1.
    AL357621
    , AL034349, AL035465, AL035470, AL035594, AL451073, AL590006 Genomic DNA. Translation: CAI41222.1.
    AL357621
    , AL034349, AL035465, AL035470, AL035594, AL451073, AL590006 Genomic DNA. Translation: CAI41224.1.
    AL035465
    , AL034349, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI42410.1.
    AL035465
    , AL034349, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI42412.1.
    AL035594
    , AL034349, AL035465, AL035470, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI43011.1.
    AL035594
    , AL034349, AL035465, AL035470, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI43013.1.
    CH471051 Genomic DNA. Translation: EAW48086.1.
    BC140775 mRNA. Translation: AAI40776.1.
    BC144512 mRNA. Translation: AAI44513.1.
    BC144513 mRNA. Translation: AAI44514.1.
    CCDSiCCDS47473.1. [Q15262-3]
    CCDS5137.1. [Q15262-2]
    PIRiJC6312.
    RefSeqiNP_001129120.1. NM_001135648.2. [Q15262-3]
    NP_002835.2. NM_002844.3. [Q15262-2]
    UniGeneiHs.155919.

    Genome annotation databases

    EnsembliENST00000368213; ENSP00000357196; ENSG00000152894. [Q15262-3]
    ENST00000368215; ENSP00000357198; ENSG00000152894. [Q15262-1]
    ENST00000368226; ENSP00000357209; ENSG00000152894. [Q15262-2]
    ENST00000532331; ENSP00000432973; ENSG00000152894. [Q15262-4]
    GeneIDi5796.
    KEGGihsa:5796.
    UCSCiuc003qbj.3. human. [Q15262-2]
    uc003qbk.3. human. [Q15262-1]
    uc010kfc.3. human. [Q15262-3]

    Polymorphism databases

    DMDMi146345496.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z70660 mRNA. Translation: CAA94519.1 .
    L77886 mRNA. Translation: AAC37599.1 .
    AL035470
    , AL034349 , AL035465 , AL035594 , AL357621 , AL451073 , AL590006 Genomic DNA. Translation: CAI21516.1 .
    AL035470
    , AL034349 , AL035465 , AL035594 , AL357621 , AL451073 , AL590006 Genomic DNA. Translation: CAI21517.1 .
    AL034349
    , AL035465 , AL035470 , AL035594 , AL357621 , AL451073 , AL590006 Genomic DNA. Translation: CAI23054.1 .
    AL034349
    , AL035465 , AL035470 , AL035594 , AL357621 , AL451073 , AL590006 Genomic DNA. Translation: CAI23055.1 .
    AL590006
    , AL034349 , AL035465 , AL035470 , AL035594 , AL357621 , AL451073 Genomic DNA. Translation: CAI39438.1 .
    AL590006
    , AL034349 , AL035465 , AL035470 , AL035594 , AL357621 , AL451073 Genomic DNA. Translation: CAI39440.1 .
    AL451073
    , AL034349 , AL035465 , AL035470 , AL035594 , AL357621 , AL590006 Genomic DNA. Translation: CAI40499.1 .
    AL451073
    , AL034349 , AL035465 , AL035470 , AL035594 , AL357621 , AL590006 Genomic DNA. Translation: CAI40501.1 .
    AL357621
    , AL034349 , AL035465 , AL035470 , AL035594 , AL451073 , AL590006 Genomic DNA. Translation: CAI41222.1 .
    AL357621
    , AL034349 , AL035465 , AL035470 , AL035594 , AL451073 , AL590006 Genomic DNA. Translation: CAI41224.1 .
    AL035465
    , AL034349 , AL035470 , AL035594 , AL357621 , AL451073 , AL590006 Genomic DNA. Translation: CAI42410.1 .
    AL035465
    , AL034349 , AL035470 , AL035594 , AL357621 , AL451073 , AL590006 Genomic DNA. Translation: CAI42412.1 .
    AL035594
    , AL034349 , AL035465 , AL035470 , AL357621 , AL451073 , AL590006 Genomic DNA. Translation: CAI43011.1 .
    AL035594
    , AL034349 , AL035465 , AL035470 , AL357621 , AL451073 , AL590006 Genomic DNA. Translation: CAI43013.1 .
    CH471051 Genomic DNA. Translation: EAW48086.1 .
    BC140775 mRNA. Translation: AAI40776.1 .
    BC144512 mRNA. Translation: AAI44513.1 .
    BC144513 mRNA. Translation: AAI44514.1 .
    CCDSi CCDS47473.1. [Q15262-3 ]
    CCDS5137.1. [Q15262-2 ]
    PIRi JC6312.
    RefSeqi NP_001129120.1. NM_001135648.2. [Q15262-3 ]
    NP_002835.2. NM_002844.3. [Q15262-2 ]
    UniGenei Hs.155919.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2C7S X-ray 1.95 A 865-1154 [» ]
    ProteinModelPortali Q15262.
    SMRi Q15262. Positions 33-596, 864-1438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111760. 9 interactions.
    IntActi Q15262. 22 interactions.
    MINTi MINT-1350116.
    STRINGi 9606.ENSP00000357209.

    PTM databases

    PhosphoSitei Q15262.

    Polymorphism databases

    DMDMi 146345496.

    Proteomic databases

    MaxQBi Q15262.
    PaxDbi Q15262.
    PRIDEi Q15262.

    Protocols and materials databases

    DNASUi 5796.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368213 ; ENSP00000357196 ; ENSG00000152894 . [Q15262-3 ]
    ENST00000368215 ; ENSP00000357198 ; ENSG00000152894 . [Q15262-1 ]
    ENST00000368226 ; ENSP00000357209 ; ENSG00000152894 . [Q15262-2 ]
    ENST00000532331 ; ENSP00000432973 ; ENSG00000152894 . [Q15262-4 ]
    GeneIDi 5796.
    KEGGi hsa:5796.
    UCSCi uc003qbj.3. human. [Q15262-2 ]
    uc003qbk.3. human. [Q15262-1 ]
    uc010kfc.3. human. [Q15262-3 ]

    Organism-specific databases

    CTDi 5796.
    GeneCardsi GC06M128331.
    H-InvDB HIX0006208.
    HIX0033189.
    HGNCi HGNC:9674. PTPRK.
    HPAi HPA054822.
    MIMi 602545. gene.
    neXtProti NX_Q15262.
    PharmGKBi PA34019.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000049029.
    HOVERGENi HBG062785.
    KOi K06776.
    OrthoDBi EOG70KGNP.
    PhylomeDBi Q15262.
    TreeFami TF312900.

    Enzyme and pathway databases

    SignaLinki Q15262.

    Miscellaneous databases

    ChiTaRSi PTPRK. human.
    EvolutionaryTracei Q15262.
    GeneWikii PTPRK.
    GenomeRNAii 5796.
    NextBioi 22570.
    PROi Q15262.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15262.
    Bgeei Q15262.
    CleanExi HS_PTPRK.
    Genevestigatori Q15262.

    Family and domain databases

    Gene3Di 2.60.40.10. 4 hits.
    3.90.190.10. 2 hits.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR000998. MAM_dom.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    [Graphical view ]
    Pfami PF00041. fn3. 2 hits.
    PF00629. MAM. 1 hit.
    PF00102. Y_phosphatase. 2 hits.
    [Graphical view ]
    PRINTSi PR00020. MAMDOMAIN.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00060. FN3. 3 hits.
    SM00409. IG. 1 hit.
    SM00137. MAM. 1 hit.
    SM00194. PTPc. 2 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 2 hits.
    SSF49899. SSF49899. 1 hit.
    SSF52799. SSF52799. 2 hits.
    PROSITEi PS50853. FN3. 3 hits.
    PS50835. IG_LIKE. 1 hit.
    PS00740. MAM_1. 1 hit.
    PS50060. MAM_2. 1 hit.
    PS00383. TYR_PHOSPHATASE_1. 2 hits.
    PS50056. TYR_PHOSPHATASE_2. 2 hits.
    PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Association of human protein-tyrosine phosphatase kappa with members of the armadillo family."
      Fuchs M., Mueller T., Lerch M., Ullrich A.
      J. Biol. Chem. 271:16712-16719(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase."
      Yang Y., Gil M.C., Choi E.Y., Park S.H., Pyun K.H., Ha H.
      Gene 186:77-82(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: Foreskin.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
      Tissue: Brain.
    6. "An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis."
      Tarcic G., Boguslavsky S.K., Wakim J., Kiuchi T., Liu A., Reinitz F., Nathanson D., Takahashi T., Mischel P.S., Ng T., Yarden Y.
      Curr. Biol. 19:1788-1798(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN EGFR REGULATION.
    7. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-416.
      Tissue: Liver.
    8. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-416.
      Tissue: Leukemic T-cell.
    9. "Large-scale structural analysis of the classical human protein tyrosine phosphatome."
      Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S.
      Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 865-1154.

    Entry informationi

    Entry nameiPTPRK_HUMAN
    AccessioniPrimary (citable) accession number: Q15262
    Secondary accession number(s): B2RTQ8
    , B7ZMG0, Q14763, Q5TG10, Q5TG11
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 1, 2007
    Last modified: October 1, 2014
    This is version 154 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3