Q15262 (PTPRK_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Receptor-type tyrosine-protein phosphatase kappa
Short name=Protein-tyrosine phosphatase kappa
Short name=R-PTP-kappa
EC=3.1.3.48

Gene names

Name:	PTPRK
Synonyms:	PTPK

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1439 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa. Ref.6
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
Subcellular location	Cell junction › adherens junction. Cell membrane; Single-pass type I membrane protein.
Tissue specificity	High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.
Post-translational modification	This protein undergoes proteolytic processing.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily. Contains 4 fibronectin type-III domains. Contains 1 Ig-like C2-type (immunoglobulin-like) domain. Contains 1 MAM domain. Contains 2 tyrosine-protein phosphatase domains.

Ontologies

Keywords
Cellular component	Cell junction Cell membrane Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protein phosphatase Receptor
PTM	Disulfide bond Glycoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cell migration Inferred from mutant phenotype PubMed 15899872. Source: UniProtKB cellular response to UV Inferred from direct assay PubMed 16849327. Source: UniProtKB cellular response to reactive oxygen species Inferred from direct assay PubMed 16849327. Source: UniProtKB focal adhesion assembly Inferred from mutant phenotype PubMed 15899872. Source: UniProtKB negative regulation of cell cycle Inferred from direct assay PubMed 15899872. Source: UniProtKB negative regulation of cell migration Inferred from direct assay PubMed 18276111. Source: UniProtKB negative regulation of keratinocyte proliferation Inferred from direct assay PubMed 16263724. Source: UniProtKB negative regulation of transcription, DNA-dependent Inferred from direct assay PubMed 18276111. Source: UniProtKB protein localization to cell surface Inferred from direct assay PubMed 18276111. Source: UniProtKB transforming growth factor beta receptor signaling pathway Inferred from direct assay PubMed 15899872. Source: UniProtKB
Cellular_component	adherens junction Inferred from electronic annotation. Source: UniProtKB-SubCell axon Inferred from electronic annotation. Source: Compara cell surface Inferred from direct assay PubMed 18276111. Source: UniProtKB cell-cell junction Inferred from direct assay Ref.1. Source: UniProtKB dendrite Inferred from electronic annotation. Source: Compara integral to plasma membrane Non-traceable author statement Ref.2. Source: UniProtKB leading edge membrane Inferred from direct assay PubMed 15899872. Source: UniProtKB neuronal cell body Inferred from electronic annotation. Source: Compara photoreceptor outer segment Inferred from electronic annotation. Source: Compara
Molecular_function	transmembrane receptor protein tyrosine phosphatase activity Non-traceable author statement Ref.2. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ERBB2	P04626	2	EBI-474052,EBI-641062
TEK	Q02763	2	EBI-474052,EBI-2257090

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q15262-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q15262-2)

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA

Isoform 3 (identifier: Q15262-3)

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA
     946-946: I → IDIWLYR

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 26

26

Potential

Chain

27 – 1439

1413

Receptor-type tyrosine-protein phosphatase kappa

PRO_0000025446

Regions

Topological domain

27 – 752

726

Extracellular Potential

Transmembrane

753 – 774

22

Helical; Potential

Topological domain

775 – 1439

665

Cytoplasmic Potential

Domain

31 – 194

164

MAM

Domain

196 – 281

86

Ig-like C2-type

Domain

291 – 383

93

Fibronectin type-III 1

Domain

389 – 485

97

Fibronectin type-III 2

Domain

490 – 589

100

Fibronectin type-III 3

Domain

597 – 680

84

Fibronectin type-III 4

Domain

887 – 1141

255

Tyrosine-protein phosphatase 1

Domain

1173 – 1435

263

Tyrosine-protein phosphatase 2

Region

1082 – 1088

7

Substrate binding By similarity

Sites

Active site

1082

1

Phosphocysteine intermediate By similarity

Active site

1376

1

Phosphocysteine intermediate By similarity

Binding site

1050

1

Substrate By similarity

Binding site

1126

1

Substrate By similarity

Site

643 – 644

2

Cleavage Probable

Amino acid modifications

Glycosylation

101

1

N-linked (GlcNAc...) Potential

Glycosylation

140

1

N-linked (GlcNAc...) Potential

Glycosylation

211

1

N-linked (GlcNAc...) Potential

Glycosylation

416

1

N-linked (GlcNAc...) Ref.7 Ref.8

Glycosylation

424

1

N-linked (GlcNAc...) Potential

Glycosylation

436

1

N-linked (GlcNAc...) Potential

Glycosylation

462

1

N-linked (GlcNAc...) Potential

Glycosylation

552

1

N-linked (GlcNAc...) Potential

Glycosylation

586

1

N-linked (GlcNAc...) Potential

Glycosylation

590

1

N-linked (GlcNAc...) Potential

Glycosylation

607

1

N-linked (GlcNAc...) Potential

Glycosylation

690

1

N-linked (GlcNAc...) Potential

Disulfide bond

216 ↔ 270

Potential

Natural variations

Alternative sequence

732

1

A → AA in isoform 2 and isoform 3.

VSP_024819

Alternative sequence

946

1

I → IDIWLYR in isoform 3.

VSP_042049

Experimental info

Sequence conflict

9

1

L → V in AAC37599. Ref.2

Sequence conflict

158

1

T → S in CAA94519. Ref.1

Sequence conflict

284

1

A → P in AAC37599. Ref.2

Sequence conflict

422

1

T → S in AAC37599. Ref.2

Sequence conflict

672 – 674

3

AEL → CRT in AAC37599. Ref.2

Sequence conflict

715

1

S → T in AAC37599. Ref.2

Sequence conflict

1366

1

E → K in AAC37599. Ref.2

Secondary structure

1

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1439

Helix Strand Turn

Details...

Helix

869 – 871

3

Helix

872 – 879

8

Beta strand

883 – 885

3

Helix

887 – 892

6

Helix

903 – 906

4

Helix

908 – 913

6

Helix

923 – 925

3

Helix

936 – 939

4

Beta strand

942 – 948

7

Beta strand

951 – 958

8

Helix

963 – 965

3

Helix

966 – 976

11

Beta strand

980 – 983

4

Beta strand

987 – 989

3

Beta strand

1001 – 1006

6

Beta strand

1009 – 1018

10

Beta strand

1020 – 1031

12

Beta strand

1038 – 1045

8

Beta strand

1050 – 1053

4

Helix

1058 – 1070

13

Beta strand

1078 – 1081

4

Beta strand

1083 – 1086

4

Helix

1087 – 1105

19

Beta strand

1106 – 1108

3

Helix

1110 – 1120

11

Helix

1128 – 1144

17

Turn

1150 – 1153

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified May 1, 2007. Version 2. Checksum: EE1EA6EA3CCA31ED	FASTA	1,439	162,102
	10 20 30 40 50 60 MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD LYDDFEWVHV 70 80 90 100 110 120 SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP 130 140 150 160 170 180 GTLNILVRVN KGPLANPIWN VTGFTGRDWL RAELAVSTFW PNEYQVIFEA EVSGGRSGYI 190 200 210 220 230 240 AIDDIQVLSY PCDKSPHFLR LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV 250 260 270 280 290 300 AQTKNINHRR FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL 310 320 330 340 350 360 LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL WHLDPDTEYE 370 380 390 400 410 420 IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE IQARRIAVDW ESLGYNITRC 430 440 450 460 470 480 HTFNVTICYH YFRGHNESKA DCLDMDPKAP QHVVNHLPPY TNVSLKMILT NPEGRKESEE 490 500 510 520 530 540 TIIQTDEDVP GPVPVKSLQG TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV 550 560 570 580 590 600 AGPPQTVSNL WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE 610 620 630 640 650 660 GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME CYQVPVTYQN 670 680 690 700 710 720 AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP LAPRKGYNIY FQAMSSVEKE 730 740 750 760 770 780 TKTQCVRIAT KAATEEPEVI PDPAKQTDRV VKIAGISAGI LVFILLLLVV ILIVKKSKLA 790 800 810 820 830 840 KKRKDAMGNT RQEMTHMVNA MDRSYADQST LHAEDPLSIT FMDQHNFSPR YENHSATAES 850 860 870 880 890 900 SRLLDVPRYL CEGTESPYQT GQLHPAIRVA DLLQHINLMK TSDSYGFKEE YESFFEGQSA 910 920 930 940 950 960 SWDVAKKDQN RAKNRYGNII AYDHSRVILQ PVEDDPSSDY INANYIDGYQ RPSHYIATQG 970 980 990 1000 1010 1020 PVHETVYDFW RMIWQEQSAC IVMVTNLVEV GRVKCYKYWP DDTEVYGDFK VTCVEMEPLA 1030 1040 1050 1060 1070 1080 EYVVRTFTLE RRGYNEIREV KQFHFTGWPD HGVPYHATGL LSFIRRVKLS NPPSAGPIVV 1090 1100 1110 1120 1130 1140 HCSAGAGRTG CYIVIDIMLD MAEREGVVDI YNCVKALRSR RINMVQTEEQ YIFIHDAILE 1150 1160 1170 1180 1190 1200 ACLCGETAIP VCEFKAAYFD MIRIDSQTNS SHLKDEFQTL NSVTPRLQAE DCSIACLPRN 1210 1220 1230 1240 1250 1260 HDKNRFMDML PPDRCLPFLI TIDGESSNYI NAALMDSYRQ PAAFIVTQYP LPNTVKDFWR 1270 1280 1290 1300 1310 1320 LVYDYGCTSI VMLNEVDLSQ GCPQYWPEEG MLRYGPIQVE CMSCSMDCDV INRIFRICNL 1330 1340 1350 1360 1370 1380 TRPQEGYLMV QQFQYLGWAS HREVPGSKRS FLKLILQVEK WQEECEEGEG RTIIHCLNGG 1390 1400 1410 1420 1430 GRSGMFCAIG IVVEMVKRQN VVDVFHAVKT LRNSKPNMVE APEQYRFCYD VALEYLESS
	Isoform 2 [UniParc]. Checksum: 41B5AD638EE63969	FASTA	1,440	162,173
	10 20 30 40 50 60 MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD LYDDFEWVHV 70 80 90 100 110 120 SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP 130 140 150 160 170 180 GTLNILVRVN KGPLANPIWN VTGFTGRDWL RAELAVSTFW PNEYQVIFEA EVSGGRSGYI 190 200 210 220 230 240 AIDDIQVLSY PCDKSPHFLR LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV 250 260 270 280 290 300 AQTKNINHRR FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL 310 320 330 340 350 360 LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL WHLDPDTEYE 370 380 390 400 410 420 IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE IQARRIAVDW ESLGYNITRC 430 440 450 460 470 480 HTFNVTICYH YFRGHNESKA DCLDMDPKAP QHVVNHLPPY TNVSLKMILT NPEGRKESEE 490 500 510 520 530 540 TIIQTDEDVP GPVPVKSLQG TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV 550 560 570 580 590 600 AGPPQTVSNL WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE 610 620 630 640 650 660 GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME CYQVPVTYQN 670 680 690 700 710 720 AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP LAPRKGYNIY FQAMSSVEKE 730 740 750 760 770 780 TKTQCVRIAT KAAATEEPEV IPDPAKQTDR VVKIAGISAG ILVFILLLLV VILIVKKSKL 790 800 810 820 830 840 AKKRKDAMGN TRQEMTHMVN AMDRSYADQS TLHAEDPLSI TFMDQHNFSP RYENHSATAE 850 860 870 880 890 900 SSRLLDVPRY LCEGTESPYQ TGQLHPAIRV ADLLQHINLM KTSDSYGFKE EYESFFEGQS 910 920 930 940 950 960 ASWDVAKKDQ NRAKNRYGNI IAYDHSRVIL QPVEDDPSSD YINANYIDGY QRPSHYIATQ 970 980 990 1000 1010 1020 GPVHETVYDF WRMIWQEQSA CIVMVTNLVE VGRVKCYKYW PDDTEVYGDF KVTCVEMEPL 1030 1040 1050 1060 1070 1080 AEYVVRTFTL ERRGYNEIRE VKQFHFTGWP DHGVPYHATG LLSFIRRVKL SNPPSAGPIV 1090 1100 1110 1120 1130 1140 VHCSAGAGRT GCYIVIDIML DMAEREGVVD IYNCVKALRS RRINMVQTEE QYIFIHDAIL 1150 1160 1170 1180 1190 1200 EACLCGETAI PVCEFKAAYF DMIRIDSQTN SSHLKDEFQT LNSVTPRLQA EDCSIACLPR 1210 1220 1230 1240 1250 1260 NHDKNRFMDM LPPDRCLPFL ITIDGESSNY INAALMDSYR QPAAFIVTQY PLPNTVKDFW 1270 1280 1290 1300 1310 1320 RLVYDYGCTS IVMLNEVDLS QGCPQYWPEE GMLRYGPIQV ECMSCSMDCD VINRIFRICN 1330 1340 1350 1360 1370 1380 LTRPQEGYLM VQQFQYLGWA SHREVPGSKR SFLKLILQVE KWQEECEEGE GRTIIHCLNG 1390 1400 1410 1420 1430 1440 GGRSGMFCAI GIVVEMVKRQ NVVDVFHAVK TLRNSKPNMV EAPEQYRFCY DVALEYLESS
	Isoform 3 [UniParc]. Checksum: 43919D3BA33C84C4	FASTA	1,446	163,020
	10 20 30 40 50 60 MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD LYDDFEWVHV 70 80 90 100 110 120 SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE NDTHCIDFSY LLYSQKGLNP 130 140 150 160 170 180 GTLNILVRVN KGPLANPIWN VTGFTGRDWL RAELAVSTFW PNEYQVIFEA EVSGGRSGYI 190 200 210 220 230 240 AIDDIQVLSY PCDKSPHFLR LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV 250 260 270 280 290 300 AQTKNINHRR FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL 310 320 330 340 350 360 LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL WHLDPDTEYE 370 380 390 400 410 420 IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE IQARRIAVDW ESLGYNITRC 430 440 450 460 470 480 HTFNVTICYH YFRGHNESKA DCLDMDPKAP QHVVNHLPPY TNVSLKMILT NPEGRKESEE 490 500 510 520 530 540 TIIQTDEDVP GPVPVKSLQG TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV 550 560 570 580 590 600 AGPPQTVSNL WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE 610 620 630 640 650 660 GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME CYQVPVTYQN 670 680 690 700 710 720 AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP LAPRKGYNIY FQAMSSVEKE 730 740 750 760 770 780 TKTQCVRIAT KAAATEEPEV IPDPAKQTDR VVKIAGISAG ILVFILLLLV VILIVKKSKL 790 800 810 820 830 840 AKKRKDAMGN TRQEMTHMVN AMDRSYADQS TLHAEDPLSI TFMDQHNFSP RYENHSATAE 850 860 870 880 890 900 SSRLLDVPRY LCEGTESPYQ TGQLHPAIRV ADLLQHINLM KTSDSYGFKE EYESFFEGQS 910 920 930 940 950 960 ASWDVAKKDQ NRAKNRYGNI IAYDHSRVIL QPVEDDPSSD YINANYIDIW LYRDGYQRPS 970 980 990 1000 1010 1020 HYIATQGPVH ETVYDFWRMI WQEQSACIVM VTNLVEVGRV KCYKYWPDDT EVYGDFKVTC 1030 1040 1050 1060 1070 1080 VEMEPLAEYV VRTFTLERRG YNEIREVKQF HFTGWPDHGV PYHATGLLSF IRRVKLSNPP 1090 1100 1110 1120 1130 1140 SAGPIVVHCS AGAGRTGCYI VIDIMLDMAE REGVVDIYNC VKALRSRRIN MVQTEEQYIF 1150 1160 1170 1180 1190 1200 IHDAILEACL CGETAIPVCE FKAAYFDMIR IDSQTNSSHL KDEFQTLNSV TPRLQAEDCS 1210 1220 1230 1240 1250 1260 IACLPRNHDK NRFMDMLPPD RCLPFLITID GESSNYINAA LMDSYRQPAA FIVTQYPLPN 1270 1280 1290 1300 1310 1320 TVKDFWRLVY DYGCTSIVML NEVDLSQGCP QYWPEEGMLR YGPIQVECMS CSMDCDVINR 1330 1340 1350 1360 1370 1380 IFRICNLTRP QEGYLMVQQF QYLGWASHRE VPGSKRSFLK LILQVEKWQE ECEEGEGRTI 1390 1400 1410 1420 1430 1440 IHCLNGGGRS GMFCAIGIVV EMVKRQNVVD VFHAVKTLRN SKPNMVEAPE QYRFCYDVAL EYLESS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Association of human protein-tyrosine phosphatase kappa with members of the armadillo family." Fuchs M., Mueller T., Lerch M., Ullrich A. J. Biol. Chem. 271:16712-16719(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase." Yang Y., Gil M.C., Choi E.Y., Park S.H., Pyun K.H., Ha H. Gene 186:77-82(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: Foreskin.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). Tissue: Brain.
[6]	"An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis." Tarcic G., Boguslavsky S.K., Wakim J., Kiuchi T., Liu A., Reinitz F., Nathanson D., Takahashi T., Mischel P.S., Ng T., Yarden Y. Curr. Biol. 19:1788-1798(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN EGFR REGULATION.
[7]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-416, MASS SPECTROMETRY. Tissue: Liver.
[8]	"Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins." Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D. Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-416, MASS SPECTROMETRY. Tissue: Leukemic T-cell.
[9]	"Large-scale structural analysis of the classical human protein tyrosine phosphatome." Barr A.J., Ugochukwu E., Lee W.H., King O.N.F., Filippakopoulos P., Alfano I., Savitsky P., Burgess-Brown N.A., Mueller S., Knapp S. Cell 136:352-363(2009) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 865-1154.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

Z70660 mRNA. Translation: CAA94519.1.
L77886 mRNA. Translation: AAC37599.1.
AL035470 , AL034349, AL035465, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI21516.1.
AL035470 , AL034349, AL035465, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI21517.1.
AL034349 , AL035465, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI23054.1.
AL034349 , AL035465, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI23055.1.
AL590006 , AL034349, AL035465, AL035470, AL035594, AL357621, AL451073 Genomic DNA. Translation: CAI39438.1.
AL590006 , AL034349, AL035465, AL035470, AL035594, AL357621, AL451073 Genomic DNA. Translation: CAI39440.1.
AL451073 , AL034349, AL035465, AL035470, AL035594, AL357621, AL590006 Genomic DNA. Translation: CAI40499.1.
AL451073 , AL034349, AL035465, AL035470, AL035594, AL357621, AL590006 Genomic DNA. Translation: CAI40501.1.
AL357621 , AL034349, AL035465, AL035470, AL035594, AL451073, AL590006 Genomic DNA. Translation: CAI41222.1.
AL357621 , AL034349, AL035465, AL035470, AL035594, AL451073, AL590006 Genomic DNA. Translation: CAI41224.1.
AL035465 , AL034349, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI42410.1.
AL035465 , AL034349, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI42412.1.
AL035594 , AL034349, AL035465, AL035470, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI43011.1.
AL035594 , AL034349, AL035465, AL035470, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI43013.1.
CH471051 Genomic DNA. Translation: EAW48086.1.
BC140775 mRNA. Translation: AAI40776.1.
BC144512 mRNA. Translation: AAI44513.1.

IPI

IPI00015756.
IPI00644648.

PIR

JC6312.

RefSeq

NP_001129120.1. NM_001135648.1.
NP_002835.2. NM_002844.3.

UniGene

Hs.155919.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2C7S	X-ray	1.95	A	865-1154	[»]

ProteinModelPortal

Q15262.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q15262. 20 interactions.

MINT

MINT-1350116.

STRING

9606.ENSP00000357209.

PTM databases

PhosphoSite

Q15262.

Polymorphism databases

DMDM

146345496.

Proteomic databases

PaxDb

Q15262.

PRIDE

Q15262.

Protocols and materials databases

DNASU

5796.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000368213; ENSP00000357196; ENSG00000152894.
ENST00000368215; ENSP00000357198; ENSG00000152894.
ENST00000368226; ENSP00000357209; ENSG00000152894.

GeneID

5796.

KEGG

hsa:5796.

UCSC

uc003qbj.3. human.
uc003qbk.3. human.
uc010kfc.3. human.

Organism-specific databases

CTD

5796.

GeneCards

GC06M128331.

H-InvDB

HIX0006208.
HIX0033189.

HGNC

HGNC:9674. PTPRK.

HPA

HPA054822.

MIM

602545. gene.

neXtProt

NX_Q15262.

PharmGKB

PA34019.

GenAtlas

Search...

Phylogenomic databases

eggNOG

COG5599.

HOGENOM

HOG000049029.

HOVERGEN

HBG062785.

KO

K06776.

Enzyme and pathway databases

Pathway_Interaction_DB

nfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes.

SignaLink

Q15262.

Gene expression databases

ArrayExpress

Q15262.

Bgee

Q15262.

CleanEx

HS_PTPRK.

Genevestigator

Q15262.

GermOnline

ENSG00000152894. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 4 hits.

InterPro

IPR008985. ConA-like_lec_gl_sf.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
[Graphical view]

Pfam

PF00041. fn3. 2 hits.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]

PRINTS

PR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.

SMART

SM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
[Graphical view]

SUPFAM

SSF49899. ConA_like_lec_gl. 1 hit.
SSF49265. FN_III-like. 3 hits.

PROSITE

PS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

PTPRK. human.

EvolutionaryTrace

Q15262.

GenomeRNAi

5796.

NextBio

22570.

SOURCE

Search...

Entry information

Entry name

PTPRK_HUMAN

Accession

Primary (citable) accession number: Q15262
Secondary accession number(s): B2RTQ8 , Q14763, Q5TG10, Q5TG11

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	May 1, 2007
Last modified:	May 29, 2013
This is version 141 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.