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Protein

Receptor-type tyrosine-protein phosphatase kappa

Gene

PTPRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1050SubstrateBy similarity1
Active sitei1082Phosphocysteine intermediateBy similarity1
Binding sitei1126SubstrateBy similarity1
Active sitei1376Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB
  • gamma-catenin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB
  • transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • cell migration Source: UniProtKB
  • cellular response to reactive oxygen species Source: UniProtKB
  • cellular response to UV Source: UniProtKB
  • focal adhesion assembly Source: UniProtKB
  • negative regulation of cell cycle Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of keratinocyte proliferation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • neuron projection development Source: Ensembl
  • protein dephosphorylation Source: UniProtKB
  • protein localization to cell surface Source: UniProtKB
  • signal transduction Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BioCyciZFISH:HS07858-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-182971. EGFR downregulation.
SignaLinkiQ15262.
SIGNORiQ15262.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase kappa (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase kappa
Short name:
R-PTP-kappa
Gene namesi
Name:PTPRK
Synonyms:PTPK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

HGNCiHGNC:9674. PTPRK.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 752ExtracellularSequence analysisAdd BLAST726
Transmembranei753 – 774HelicalSequence analysisAdd BLAST22
Topological domaini775 – 1439CytoplasmicSequence analysisAdd BLAST665

GO - Cellular componenti

  • adherens junction Source: UniProtKB-SubCell
  • axon Source: Ensembl
  • cell-cell junction Source: UniProtKB
  • cell surface Source: UniProtKB
  • dendrite Source: Ensembl
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • leading edge membrane Source: UniProtKB
  • neuronal cell body Source: Ensembl
  • photoreceptor outer segment Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5796.
OpenTargetsiENSG00000152894.
ENSG00000273993.
PharmGKBiPA34019.

Polymorphism and mutation databases

BioMutaiPTPRK.
DMDMi146345496.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002544627 – 1439Receptor-type tyrosine-protein phosphatase kappaAdd BLAST1413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1
Glycosylationi140N-linked (GlcNAc...)Sequence analysis1
Glycosylationi211N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi216 ↔ 270PROSITE-ProRule annotation
Glycosylationi416N-linked (GlcNAc...)2 Publications1
Glycosylationi424N-linked (GlcNAc...)Sequence analysis1
Glycosylationi436N-linked (GlcNAc...)Sequence analysis1
Glycosylationi462N-linked (GlcNAc...)Sequence analysis1
Glycosylationi552N-linked (GlcNAc...)Sequence analysis1
Glycosylationi586N-linked (GlcNAc...)Sequence analysis1
Glycosylationi590N-linked (GlcNAc...)Sequence analysis1
Glycosylationi607N-linked (GlcNAc...)Sequence analysis1
Glycosylationi690N-linked (GlcNAc...)Sequence analysis1
Modified residuei856PhosphoserineBy similarity1

Post-translational modificationi

This protein undergoes proteolytic processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei643 – 644CleavageCurated2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15262.
MaxQBiQ15262.
PaxDbiQ15262.
PeptideAtlasiQ15262.
PRIDEiQ15262.

PTM databases

DEPODiQ15262.
iPTMnetiQ15262.
PhosphoSitePlusiQ15262.

Expressioni

Tissue specificityi

High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.

Gene expression databases

BgeeiENSG00000152894.
CleanExiHS_PTPRK.
ExpressionAtlasiQ15262. baseline and differential.
GenevisibleiQ15262. HS.

Organism-specific databases

HPAiHPA054822.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ERBB2P046262EBI-474052,EBI-641062
LOXP283004EBI-474052,EBI-3893481
TEKQ027632EBI-474052,EBI-2257090

GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB
  • gamma-catenin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111760. 102 interactors.
IntActiQ15262. 25 interactors.
MINTiMINT-1350116.
STRINGi9606.ENSP00000357196.

Structurei

Secondary structure

11439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi869 – 871Combined sources3
Helixi872 – 879Combined sources8
Beta strandi883 – 885Combined sources3
Helixi887 – 892Combined sources6
Helixi903 – 906Combined sources4
Helixi908 – 913Combined sources6
Helixi923 – 925Combined sources3
Helixi936 – 939Combined sources4
Beta strandi942 – 948Combined sources7
Beta strandi951 – 958Combined sources8
Helixi963 – 965Combined sources3
Helixi966 – 976Combined sources11
Beta strandi980 – 983Combined sources4
Beta strandi987 – 989Combined sources3
Beta strandi1001 – 1006Combined sources6
Beta strandi1009 – 1018Combined sources10
Beta strandi1020 – 1031Combined sources12
Beta strandi1038 – 1045Combined sources8
Beta strandi1050 – 1053Combined sources4
Helixi1058 – 1070Combined sources13
Beta strandi1078 – 1081Combined sources4
Beta strandi1083 – 1086Combined sources4
Helixi1087 – 1105Combined sources19
Beta strandi1106 – 1108Combined sources3
Helixi1110 – 1120Combined sources11
Helixi1128 – 1144Combined sources17
Turni1150 – 1153Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7SX-ray1.95A865-1154[»]
ProteinModelPortaliQ15262.
SMRiQ15262.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15262.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 194MAMPROSITE-ProRule annotationAdd BLAST164
Domaini196 – 281Ig-like C2-typeAdd BLAST86
Domaini294 – 389Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini392 – 488Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini491 – 595Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST105
Domaini597 – 680Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST84
Domaini887 – 1141Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST255
Domaini1173 – 1435Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST263

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1082 – 1088Substrate bindingBy similarity7

Sequence similaritiesi

Contains 4 fibronectin type-III domains.PROSITE-ProRule annotation
Contains 1 MAM domain.PROSITE-ProRule annotation
Contains 2 tyrosine-protein phosphatase domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000049029.
HOVERGENiHBG062785.
InParanoidiQ15262.
KOiK06776.
PhylomeDBiQ15262.
TreeFamiTF312900.

Family and domain databases

CDDicd00063. FN3. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15262-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD
60 70 80 90 100
LYDDFEWVHV SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE
110 120 130 140 150
NDTHCIDFSY LLYSQKGLNP GTLNILVRVN KGPLANPIWN VTGFTGRDWL
160 170 180 190 200
RAELAVSTFW PNEYQVIFEA EVSGGRSGYI AIDDIQVLSY PCDKSPHFLR
210 220 230 240 250
LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV AQTKNINHRR
260 270 280 290 300
FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL
310 320 330 340 350
LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL
360 370 380 390 400
WHLDPDTEYE IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE
410 420 430 440 450
IQARRIAVDW ESLGYNITRC HTFNVTICYH YFRGHNESKA DCLDMDPKAP
460 470 480 490 500
QHVVNHLPPY TNVSLKMILT NPEGRKESEE TIIQTDEDVP GPVPVKSLQG
510 520 530 540 550
TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV AGPPQTVSNL
560 570 580 590 600
WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE
610 620 630 640 650
GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME
660 670 680 690 700
CYQVPVTYQN AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP
710 720 730 740 750
LAPRKGYNIY FQAMSSVEKE TKTQCVRIAT KAATEEPEVI PDPAKQTDRV
760 770 780 790 800
VKIAGISAGI LVFILLLLVV ILIVKKSKLA KKRKDAMGNT RQEMTHMVNA
810 820 830 840 850
MDRSYADQST LHAEDPLSIT FMDQHNFSPR YENHSATAES SRLLDVPRYL
860 870 880 890 900
CEGTESPYQT GQLHPAIRVA DLLQHINLMK TSDSYGFKEE YESFFEGQSA
910 920 930 940 950
SWDVAKKDQN RAKNRYGNII AYDHSRVILQ PVEDDPSSDY INANYIDGYQ
960 970 980 990 1000
RPSHYIATQG PVHETVYDFW RMIWQEQSAC IVMVTNLVEV GRVKCYKYWP
1010 1020 1030 1040 1050
DDTEVYGDFK VTCVEMEPLA EYVVRTFTLE RRGYNEIREV KQFHFTGWPD
1060 1070 1080 1090 1100
HGVPYHATGL LSFIRRVKLS NPPSAGPIVV HCSAGAGRTG CYIVIDIMLD
1110 1120 1130 1140 1150
MAEREGVVDI YNCVKALRSR RINMVQTEEQ YIFIHDAILE ACLCGETAIP
1160 1170 1180 1190 1200
VCEFKAAYFD MIRIDSQTNS SHLKDEFQTL NSVTPRLQAE DCSIACLPRN
1210 1220 1230 1240 1250
HDKNRFMDML PPDRCLPFLI TIDGESSNYI NAALMDSYRQ PAAFIVTQYP
1260 1270 1280 1290 1300
LPNTVKDFWR LVYDYGCTSI VMLNEVDLSQ GCPQYWPEEG MLRYGPIQVE
1310 1320 1330 1340 1350
CMSCSMDCDV INRIFRICNL TRPQEGYLMV QQFQYLGWAS HREVPGSKRS
1360 1370 1380 1390 1400
FLKLILQVEK WQEECEEGEG RTIIHCLNGG GRSGMFCAIG IVVEMVKRQN
1410 1420 1430
VVDVFHAVKT LRNSKPNMVE APEQYRFCYD VALEYLESS
Length:1,439
Mass (Da):162,102
Last modified:May 1, 2007 - v2
Checksum:iEE1EA6EA3CCA31ED
GO
Isoform 2 (identifier: Q15262-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA

Show »
Length:1,440
Mass (Da):162,173
Checksum:i41B5AD638EE63969
GO
Isoform 3 (identifier: Q15262-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA
     946-946: I → IDIWLYR

Note: No experimental confirmation available.
Show »
Length:1,446
Mass (Da):163,020
Checksum:i43919D3BA33C84C4
GO
Isoform 4 (identifier: Q15262-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA
     831-831: Y → LPNDPLVPTAVLVPITD
     946-946: I → IDIWLYR

Note: No experimental confirmation available.
Show »
Length:1,462
Mass (Da):164,613
Checksum:iC3CEA4670A00B758
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → V in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti158T → S in CAA94519 (PubMed:8663237).Curated1
Sequence conflicti284A → P in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti422T → S in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti672 – 674AEL → CRT in AAC37599 (PubMed:9047348).Curated3
Sequence conflicti715S → T in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti1366E → K in AAC37599 (PubMed:9047348).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024819732A → AA in isoform 2, isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_054480831Y → LPNDPLVPTAVLVPITD in isoform 4. 1 Publication1
Alternative sequenceiVSP_042049946I → IDIWLYR in isoform 3 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70660 mRNA. Translation: CAA94519.1.
L77886 mRNA. Translation: AAC37599.1.
AL035470
, AL034349, AL035465, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI21516.1.
AL035470
, AL034349, AL035465, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI21517.1.
AL034349
, AL035465, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI23054.1.
AL034349
, AL035465, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI23055.1.
AL590006
, AL034349, AL035465, AL035470, AL035594, AL357621, AL451073 Genomic DNA. Translation: CAI39438.1.
AL590006
, AL034349, AL035465, AL035470, AL035594, AL357621, AL451073 Genomic DNA. Translation: CAI39440.1.
AL451073
, AL034349, AL035465, AL035470, AL035594, AL357621, AL590006 Genomic DNA. Translation: CAI40499.1.
AL451073
, AL034349, AL035465, AL035470, AL035594, AL357621, AL590006 Genomic DNA. Translation: CAI40501.1.
AL357621
, AL034349, AL035465, AL035470, AL035594, AL451073, AL590006 Genomic DNA. Translation: CAI41222.1.
AL357621
, AL034349, AL035465, AL035470, AL035594, AL451073, AL590006 Genomic DNA. Translation: CAI41224.1.
AL035465
, AL034349, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI42410.1.
AL035465
, AL034349, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI42412.1.
AL035594
, AL034349, AL035465, AL035470, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI43011.1.
AL035594
, AL034349, AL035465, AL035470, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI43013.1.
CH471051 Genomic DNA. Translation: EAW48086.1.
BC140775 mRNA. Translation: AAI40776.1.
BC144512 mRNA. Translation: AAI44513.1.
BC144513 mRNA. Translation: AAI44514.1.
CCDSiCCDS47473.1. [Q15262-3]
CCDS5137.1. [Q15262-2]
CCDS75517.1. [Q15262-1]
CCDS78179.1. [Q15262-4]
PIRiJC6312.
RefSeqiNP_001129120.1. NM_001135648.2. [Q15262-3]
NP_001278910.1. NM_001291981.1. [Q15262-4]
NP_001278913.1. NM_001291984.1. [Q15262-1]
NP_002835.2. NM_002844.3. [Q15262-2]
UniGeneiHs.155919.

Genome annotation databases

EnsembliENST00000368213; ENSP00000357196; ENSG00000152894. [Q15262-3]
ENST00000368215; ENSP00000357198; ENSG00000152894. [Q15262-1]
ENST00000368226; ENSP00000357209; ENSG00000152894. [Q15262-2]
ENST00000532331; ENSP00000432973; ENSG00000152894. [Q15262-4]
ENST00000618215; ENSP00000484742; ENSG00000273993. [Q15262-3]
ENST00000618924; ENSP00000483766; ENSG00000273993. [Q15262-2]
ENST00000619256; ENSP00000477791; ENSG00000273993. [Q15262-4]
ENST00000628183; ENSP00000486442; ENSG00000273993. [Q15262-1]
GeneIDi5796.
KEGGihsa:5796.
UCSCiuc003qbj.4. human. [Q15262-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70660 mRNA. Translation: CAA94519.1.
L77886 mRNA. Translation: AAC37599.1.
AL035470
, AL034349, AL035465, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI21516.1.
AL035470
, AL034349, AL035465, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI21517.1.
AL034349
, AL035465, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI23054.1.
AL034349
, AL035465, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI23055.1.
AL590006
, AL034349, AL035465, AL035470, AL035594, AL357621, AL451073 Genomic DNA. Translation: CAI39438.1.
AL590006
, AL034349, AL035465, AL035470, AL035594, AL357621, AL451073 Genomic DNA. Translation: CAI39440.1.
AL451073
, AL034349, AL035465, AL035470, AL035594, AL357621, AL590006 Genomic DNA. Translation: CAI40499.1.
AL451073
, AL034349, AL035465, AL035470, AL035594, AL357621, AL590006 Genomic DNA. Translation: CAI40501.1.
AL357621
, AL034349, AL035465, AL035470, AL035594, AL451073, AL590006 Genomic DNA. Translation: CAI41222.1.
AL357621
, AL034349, AL035465, AL035470, AL035594, AL451073, AL590006 Genomic DNA. Translation: CAI41224.1.
AL035465
, AL034349, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI42410.1.
AL035465
, AL034349, AL035470, AL035594, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI42412.1.
AL035594
, AL034349, AL035465, AL035470, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI43011.1.
AL035594
, AL034349, AL035465, AL035470, AL357621, AL451073, AL590006 Genomic DNA. Translation: CAI43013.1.
CH471051 Genomic DNA. Translation: EAW48086.1.
BC140775 mRNA. Translation: AAI40776.1.
BC144512 mRNA. Translation: AAI44513.1.
BC144513 mRNA. Translation: AAI44514.1.
CCDSiCCDS47473.1. [Q15262-3]
CCDS5137.1. [Q15262-2]
CCDS75517.1. [Q15262-1]
CCDS78179.1. [Q15262-4]
PIRiJC6312.
RefSeqiNP_001129120.1. NM_001135648.2. [Q15262-3]
NP_001278910.1. NM_001291981.1. [Q15262-4]
NP_001278913.1. NM_001291984.1. [Q15262-1]
NP_002835.2. NM_002844.3. [Q15262-2]
UniGeneiHs.155919.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7SX-ray1.95A865-1154[»]
ProteinModelPortaliQ15262.
SMRiQ15262.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111760. 102 interactors.
IntActiQ15262. 25 interactors.
MINTiMINT-1350116.
STRINGi9606.ENSP00000357196.

PTM databases

DEPODiQ15262.
iPTMnetiQ15262.
PhosphoSitePlusiQ15262.

Polymorphism and mutation databases

BioMutaiPTPRK.
DMDMi146345496.

Proteomic databases

EPDiQ15262.
MaxQBiQ15262.
PaxDbiQ15262.
PeptideAtlasiQ15262.
PRIDEiQ15262.

Protocols and materials databases

DNASUi5796.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000368213; ENSP00000357196; ENSG00000152894. [Q15262-3]
ENST00000368215; ENSP00000357198; ENSG00000152894. [Q15262-1]
ENST00000368226; ENSP00000357209; ENSG00000152894. [Q15262-2]
ENST00000532331; ENSP00000432973; ENSG00000152894. [Q15262-4]
ENST00000618215; ENSP00000484742; ENSG00000273993. [Q15262-3]
ENST00000618924; ENSP00000483766; ENSG00000273993. [Q15262-2]
ENST00000619256; ENSP00000477791; ENSG00000273993. [Q15262-4]
ENST00000628183; ENSP00000486442; ENSG00000273993. [Q15262-1]
GeneIDi5796.
KEGGihsa:5796.
UCSCiuc003qbj.4. human. [Q15262-1]

Organism-specific databases

CTDi5796.
DisGeNETi5796.
GeneCardsiPTPRK.
H-InvDBHIX0006208.
HIX0033189.
HGNCiHGNC:9674. PTPRK.
HPAiHPA054822.
MIMi602545. gene.
neXtProtiNX_Q15262.
OpenTargetsiENSG00000152894.
ENSG00000273993.
PharmGKBiPA34019.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4228. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00760000118900.
HOGENOMiHOG000049029.
HOVERGENiHBG062785.
InParanoidiQ15262.
KOiK06776.
PhylomeDBiQ15262.
TreeFamiTF312900.

Enzyme and pathway databases

BioCyciZFISH:HS07858-MONOMER.
BRENDAi3.1.3.48. 2681.
ReactomeiR-HSA-182971. EGFR downregulation.
SignaLinkiQ15262.
SIGNORiQ15262.

Miscellaneous databases

ChiTaRSiPTPRK. human.
EvolutionaryTraceiQ15262.
GeneWikiiPTPRK.
GenomeRNAii5796.
PROiQ15262.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000152894.
CleanExiHS_PTPRK.
ExpressionAtlasiQ15262. baseline and differential.
GenevisibleiQ15262. HS.

Family and domain databases

CDDicd00063. FN3. 2 hits.
cd06263. MAM. 1 hit.
Gene3Di2.60.40.10. 4 hits.
3.90.190.10. 2 hits.
InterProiIPR013320. ConA-like_dom.
IPR003961. FN3_dom.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR000998. MAM_dom.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00041. fn3. 2 hits.
PF07679. I-set. 1 hit.
PF00629. MAM. 1 hit.
PF00102. Y_phosphatase. 2 hits.
[Graphical view]
PRINTSiPR00020. MAMDOMAIN.
PR00700. PRTYPHPHTASE.
SMARTiSM00060. FN3. 3 hits.
SM00409. IG. 1 hit.
SM00137. MAM. 1 hit.
SM00194. PTPc. 2 hits.
SM00404. PTPc_motif. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
SSF49265. SSF49265. 2 hits.
SSF49899. SSF49899. 1 hit.
SSF52799. SSF52799. 2 hits.
PROSITEiPS50853. FN3. 3 hits.
PS50835. IG_LIKE. 1 hit.
PS00740. MAM_1. 1 hit.
PS50060. MAM_2. 1 hit.
PS00383. TYR_PHOSPHATASE_1. 2 hits.
PS50056. TYR_PHOSPHATASE_2. 2 hits.
PS50055. TYR_PHOSPHATASE_PTP. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRK_HUMAN
AccessioniPrimary (citable) accession number: Q15262
Secondary accession number(s): B2RTQ8
, B7ZMG0, Q14763, Q5TG10, Q5TG11
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 2007
Last modified: November 30, 2016
This is version 177 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.