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Protein

Receptor-type tyrosine-protein phosphatase kappa

Gene

PTPRK

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa.1 Publication

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei1050SubstrateBy similarity1
Active sitei1082Phosphocysteine intermediateBy similarity1
Binding sitei1126SubstrateBy similarity1
Active sitei1376Phosphocysteine intermediateBy similarity1

GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB
  • gamma-catenin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: UniProtKB
  • transmembrane receptor protein tyrosine phosphatase activity Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: UniProtKB
  • cell migration Source: UniProtKB
  • cellular response to reactive oxygen species Source: UniProtKB
  • cellular response to UV Source: UniProtKB
  • focal adhesion assembly Source: UniProtKB
  • negative regulation of cell cycle Source: UniProtKB
  • negative regulation of cell migration Source: UniProtKB
  • negative regulation of cell proliferation Source: UniProtKB
  • negative regulation of keratinocyte proliferation Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • neuron projection development Source: Ensembl
  • protein dephosphorylation Source: UniProtKB
  • protein localization to cell surface Source: UniProtKB
  • signal transduction Source: UniProtKB
  • transforming growth factor beta receptor signaling pathway Source: UniProtKB

Keywordsi

Molecular functionHydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BRENDAi3.1.3.48 2681
ReactomeiR-HSA-182971 EGFR downregulation
SignaLinkiQ15262
SIGNORiQ15262

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase kappa (EC:3.1.3.48)
Short name:
Protein-tyrosine phosphatase kappa
Short name:
R-PTP-kappa
Gene namesi
Name:PTPRK
Synonyms:PTPK
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000152894.14
HGNCiHGNC:9674 PTPRK
MIMi602545 gene
neXtProtiNX_Q15262

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 752ExtracellularSequence analysisAdd BLAST726
Transmembranei753 – 774HelicalSequence analysisAdd BLAST22
Topological domaini775 – 1439CytoplasmicSequence analysisAdd BLAST665

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5796
OpenTargetsiENSG00000152894
PharmGKBiPA34019

Polymorphism and mutation databases

BioMutaiPTPRK
DMDMi146345496

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000002544627 – 1439Receptor-type tyrosine-protein phosphatase kappaAdd BLAST1413

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi101N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi140N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi211N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi216 ↔ 270PROSITE-ProRule annotation
Glycosylationi416N-linked (GlcNAc...) asparagine2 Publications1
Glycosylationi424N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi436N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi462N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi552N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi586N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi590N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi607N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi690N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei856PhosphoserineBy similarity1

Post-translational modificationi

This protein undergoes proteolytic processing.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei643 – 644CleavageCurated2

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15262
MaxQBiQ15262
PaxDbiQ15262
PeptideAtlasiQ15262
PRIDEiQ15262

PTM databases

DEPODiQ15262
iPTMnetiQ15262
PhosphoSitePlusiQ15262

Expressioni

Tissue specificityi

High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.

Gene expression databases

BgeeiENSG00000152894
CleanExiHS_PTPRK
ExpressionAtlasiQ15262 baseline and differential
GenevisibleiQ15262 HS

Organism-specific databases

HPAiHPA054056
HPA054822

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • beta-catenin binding Source: UniProtKB
  • gamma-catenin binding Source: UniProtKB
  • protein kinase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi111760, 119 interactors
IntActiQ15262, 25 interactors
MINTiQ15262
STRINGi9606.ENSP00000357196

Structurei

Secondary structure

11439
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi869 – 871Combined sources3
Helixi872 – 879Combined sources8
Beta strandi883 – 885Combined sources3
Helixi887 – 892Combined sources6
Helixi903 – 906Combined sources4
Helixi908 – 913Combined sources6
Helixi923 – 925Combined sources3
Helixi936 – 939Combined sources4
Beta strandi942 – 948Combined sources7
Beta strandi951 – 958Combined sources8
Helixi963 – 965Combined sources3
Helixi966 – 976Combined sources11
Beta strandi980 – 983Combined sources4
Beta strandi987 – 989Combined sources3
Beta strandi1001 – 1006Combined sources6
Beta strandi1009 – 1018Combined sources10
Beta strandi1020 – 1031Combined sources12
Beta strandi1038 – 1045Combined sources8
Beta strandi1050 – 1053Combined sources4
Helixi1058 – 1070Combined sources13
Beta strandi1078 – 1081Combined sources4
Beta strandi1083 – 1086Combined sources4
Helixi1087 – 1105Combined sources19
Beta strandi1106 – 1108Combined sources3
Helixi1110 – 1120Combined sources11
Helixi1128 – 1144Combined sources17
Turni1150 – 1153Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2C7SX-ray1.95A865-1154[»]
ProteinModelPortaliQ15262
SMRiQ15262
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15262

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 194MAMPROSITE-ProRule annotationAdd BLAST164
Domaini196 – 281Ig-like C2-typeAdd BLAST86
Domaini294 – 389Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST96
Domaini392 – 488Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST97
Domaini491 – 595Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST105
Domaini597 – 680Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST84
Domaini887 – 1141Tyrosine-protein phosphatase 1PROSITE-ProRule annotationAdd BLAST255
Domaini1173 – 1435Tyrosine-protein phosphatase 2PROSITE-ProRule annotationAdd BLAST263

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1082 – 1088Substrate bindingBy similarity7

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4228 Eukaryota
COG5599 LUCA
GeneTreeiENSGT00760000118900
HOGENOMiHOG000049029
HOVERGENiHBG062785
InParanoidiQ15262
KOiK06776
PhylomeDBiQ15262
TreeFamiTF312900

Family and domain databases

CDDicd00063 FN3, 2 hits
cd06263 MAM, 1 hit
Gene3Di2.60.40.10, 4 hits
3.90.190.10, 2 hits
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR000998 MAM_dom
IPR029021 Prot-tyrosine_phosphatase-like
IPR000242 PTPase_domain
IPR016130 Tyr_Pase_AS
IPR003595 Tyr_Pase_cat
IPR000387 TYR_PHOSPHATASE_dom
PfamiView protein in Pfam
PF00041 fn3, 2 hits
PF07679 I-set, 1 hit
PF00629 MAM, 1 hit
PF00102 Y_phosphatase, 2 hits
PRINTSiPR00020 MAMDOMAIN
PR00700 PRTYPHPHTASE
SMARTiView protein in SMART
SM00060 FN3, 3 hits
SM00409 IG, 1 hit
SM00137 MAM, 1 hit
SM00194 PTPc, 2 hits
SM00404 PTPc_motif, 2 hits
SUPFAMiSSF48726 SSF48726, 1 hit
SSF49265 SSF49265, 2 hits
SSF49899 SSF49899, 1 hit
SSF52799 SSF52799, 2 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 3 hits
PS50835 IG_LIKE, 1 hit
PS00740 MAM_1, 1 hit
PS50060 MAM_2, 1 hit
PS00383 TYR_PHOSPHATASE_1, 2 hits
PS50056 TYR_PHOSPHATASE_2, 2 hits
PS50055 TYR_PHOSPHATASE_PTP, 2 hits

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15262-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDTTAAAALP AFVALLLLSP WPLLGSAQGQ FSAGGCTFDD GPGACDYHQD
60 70 80 90 100
LYDDFEWVHV SAQEPHYLPP EMPQGSYMIV DSSDHDPGEK ARLQLPTMKE
110 120 130 140 150
NDTHCIDFSY LLYSQKGLNP GTLNILVRVN KGPLANPIWN VTGFTGRDWL
160 170 180 190 200
RAELAVSTFW PNEYQVIFEA EVSGGRSGYI AIDDIQVLSY PCDKSPHFLR
210 220 230 240 250
LGDVEVNAGQ NATFQCIATG RDAVHNKLWL QRRNGEDIPV AQTKNINHRR
260 270 280 290 300
FAASFRLQEV TKTDQDLYRC VTQSERGSGV SNFAQLIVRE PPRPIAPPQL
310 320 330 340 350
LGVGPTYLLI QLNANSIIGD GPIILKEVEY RMTSGSWTET HAVNAPTYKL
360 370 380 390 400
WHLDPDTEYE IRVLLTRPGE GGTGLPGPPL ITRTKCAEPM RTPKTLKIAE
410 420 430 440 450
IQARRIAVDW ESLGYNITRC HTFNVTICYH YFRGHNESKA DCLDMDPKAP
460 470 480 490 500
QHVVNHLPPY TNVSLKMILT NPEGRKESEE TIIQTDEDVP GPVPVKSLQG
510 520 530 540 550
TSFENKIFLN WKEPLDPNGI ITQYEISYSS IRSFDPAVPV AGPPQTVSNL
560 570 580 590 600
WNSTHHVFMH LHPGTTYQFF IRASTVKGFG PATAINVTTN ISAPTLPDYE
610 620 630 640 650
GVDASLNETA TTITVLLRPA QAKGAPISAY QIVVEELHPH RTKREAGAME
660 670 680 690 700
CYQVPVTYQN AMSGGAPYYF AAELPPGNLP EPAPFTVGDN RTYQGFWNPP
710 720 730 740 750
LAPRKGYNIY FQAMSSVEKE TKTQCVRIAT KAATEEPEVI PDPAKQTDRV
760 770 780 790 800
VKIAGISAGI LVFILLLLVV ILIVKKSKLA KKRKDAMGNT RQEMTHMVNA
810 820 830 840 850
MDRSYADQST LHAEDPLSIT FMDQHNFSPR YENHSATAES SRLLDVPRYL
860 870 880 890 900
CEGTESPYQT GQLHPAIRVA DLLQHINLMK TSDSYGFKEE YESFFEGQSA
910 920 930 940 950
SWDVAKKDQN RAKNRYGNII AYDHSRVILQ PVEDDPSSDY INANYIDGYQ
960 970 980 990 1000
RPSHYIATQG PVHETVYDFW RMIWQEQSAC IVMVTNLVEV GRVKCYKYWP
1010 1020 1030 1040 1050
DDTEVYGDFK VTCVEMEPLA EYVVRTFTLE RRGYNEIREV KQFHFTGWPD
1060 1070 1080 1090 1100
HGVPYHATGL LSFIRRVKLS NPPSAGPIVV HCSAGAGRTG CYIVIDIMLD
1110 1120 1130 1140 1150
MAEREGVVDI YNCVKALRSR RINMVQTEEQ YIFIHDAILE ACLCGETAIP
1160 1170 1180 1190 1200
VCEFKAAYFD MIRIDSQTNS SHLKDEFQTL NSVTPRLQAE DCSIACLPRN
1210 1220 1230 1240 1250
HDKNRFMDML PPDRCLPFLI TIDGESSNYI NAALMDSYRQ PAAFIVTQYP
1260 1270 1280 1290 1300
LPNTVKDFWR LVYDYGCTSI VMLNEVDLSQ GCPQYWPEEG MLRYGPIQVE
1310 1320 1330 1340 1350
CMSCSMDCDV INRIFRICNL TRPQEGYLMV QQFQYLGWAS HREVPGSKRS
1360 1370 1380 1390 1400
FLKLILQVEK WQEECEEGEG RTIIHCLNGG GRSGMFCAIG IVVEMVKRQN
1410 1420 1430
VVDVFHAVKT LRNSKPNMVE APEQYRFCYD VALEYLESS
Length:1,439
Mass (Da):162,102
Last modified:May 1, 2007 - v2
Checksum:iEE1EA6EA3CCA31ED
GO
Isoform 2 (identifier: Q15262-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA

Show »
Length:1,440
Mass (Da):162,173
Checksum:i41B5AD638EE63969
GO
Isoform 3 (identifier: Q15262-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA
     946-946: I → IDIWLYR

Note: No experimental confirmation available.
Show »
Length:1,446
Mass (Da):163,020
Checksum:i43919D3BA33C84C4
GO
Isoform 4 (identifier: Q15262-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     732-732: A → AA
     831-831: Y → LPNDPLVPTAVLVPITD
     946-946: I → IDIWLYR

Note: No experimental confirmation available.
Show »
Length:1,462
Mass (Da):164,613
Checksum:iC3CEA4670A00B758
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti9L → V in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti158T → S in CAA94519 (PubMed:8663237).Curated1
Sequence conflicti284A → P in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti422T → S in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti672 – 674AEL → CRT in AAC37599 (PubMed:9047348).Curated3
Sequence conflicti715S → T in AAC37599 (PubMed:9047348).Curated1
Sequence conflicti1366E → K in AAC37599 (PubMed:9047348).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_024819732A → AA in isoform 2, isoform 3 and isoform 4. 2 Publications1
Alternative sequenceiVSP_054480831Y → LPNDPLVPTAVLVPITD in isoform 4. 1 Publication1
Alternative sequenceiVSP_042049946I → IDIWLYR in isoform 3 and isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z70660 mRNA Translation: CAA94519.1
L77886 mRNA Translation: AAC37599.1
AL035470 Genomic DNA No translation available.
AL034349 Genomic DNA No translation available.
AL590006 Genomic DNA No translation available.
AL451073 Genomic DNA No translation available.
AL357621 Genomic DNA No translation available.
AL035465 Genomic DNA No translation available.
AL035594 Genomic DNA No translation available.
CH471051 Genomic DNA Translation: EAW48086.1
BC140775 mRNA Translation: AAI40776.1
BC144512 mRNA Translation: AAI44513.1
BC144513 mRNA Translation: AAI44514.1
CCDSiCCDS47473.1 [Q15262-3]
CCDS5137.1 [Q15262-2]
CCDS75517.1 [Q15262-1]
CCDS78179.1 [Q15262-4]
PIRiJC6312
RefSeqiNP_001129120.1, NM_001135648.2 [Q15262-3]
NP_001278910.1, NM_001291981.1 [Q15262-4]
NP_001278913.1, NM_001291984.1 [Q15262-1]
NP_002835.2, NM_002844.3 [Q15262-2]
UniGeneiHs.155919

Genome annotation databases

EnsembliENST00000368213; ENSP00000357196; ENSG00000152894 [Q15262-3]
ENST00000368215; ENSP00000357198; ENSG00000152894 [Q15262-1]
ENST00000368226; ENSP00000357209; ENSG00000152894 [Q15262-2]
ENST00000532331; ENSP00000432973; ENSG00000152894 [Q15262-4]
ENST00000618215; ENSP00000484742; ENSG00000273993 [Q15262-3]
ENST00000618924; ENSP00000483766; ENSG00000273993 [Q15262-2]
ENST00000619256; ENSP00000477791; ENSG00000273993 [Q15262-4]
ENST00000628183; ENSP00000486442; ENSG00000273993 [Q15262-1]
GeneIDi5796
KEGGihsa:5796
UCSCiuc003qbj.4 human [Q15262-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPTPRK_HUMAN
AccessioniPrimary (citable) accession number: Q15262
Secondary accession number(s): B2RTQ8
, B7ZMG0, Q14763, Q5TG10, Q5TG11
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 1, 2007
Last modified: February 28, 2018
This is version 186 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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