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Q15256

- PTPRR_HUMAN

UniProt

Q15256 - PTPRR_HUMAN

Protein

Receptor-type tyrosine-protein phosphatase R

Gene

PTPRR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 2 (06 Mar 2007)
      Previous versions | rss
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    Functioni

    Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus By similarity.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei554 – 5541SubstrateBy similarity
    Active sitei588 – 5881Phosphocysteine intermediatePROSITE-ProRule annotation
    Binding sitei632 – 6321SubstrateBy similarity

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein kinase binding Source: UniProtKB
    3. protein tyrosine phosphatase activity Source: ProtInc
    4. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

    GO - Biological processi

    1. in utero embryonic development Source: UniProtKB
    2. protein dephosphorylation Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase, Receptor

    Enzyme and pathway databases

    BRENDAi3.1.3.48. 2681.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Receptor-type tyrosine-protein phosphatase R (EC:3.1.3.48)
    Short name:
    R-PTP-R
    Alternative name(s):
    Ch-1PTPase
    NC-PTPCOM1
    Protein-tyrosine phosphatase PCPTP1
    Gene namesi
    Name:PTPRR
    Synonyms:ECPTP, PTPRQ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:9680. PTPRR.

    Subcellular locationi

    Isoform Delta : Cytoplasmperinuclear region
    Note: Locates to the perinuclear areas within the cytoplasm.
    Isoform Gamma : Cytoplasmperinuclear region
    Note: Locates to the perinuclear areas within the cytoplasm.

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. integral component of membrane Source: UniProtKB-KW
    3. perinuclear region of cytoplasm Source: UniProtKB-SubCell
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34025.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 657636Receptor-type tyrosine-protein phosphatase RPRO_0000025459Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
    Modified residuei339 – 3391Phosphoserine; by PKABy similarity

    Keywords - PTMi

    Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ15256.
    PaxDbiQ15256.
    PRIDEiQ15256.

    PTM databases

    PhosphoSiteiQ15256.

    Expressioni

    Tissue specificityi

    Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.1 Publication

    Gene expression databases

    ArrayExpressiQ15256.
    BgeeiQ15256.
    CleanExiHS_PTPRQ.
    HS_PTPRR.
    GenevestigatoriQ15256.

    Organism-specific databases

    HPAiCAB011461.
    HPA011851.

    Interactioni

    Subunit structurei

    Interacts with MAPKs.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MAPK1P284823EBI-2265659,EBI-959949
    MAPK14Q165393EBI-2265659,EBI-73946

    Protein-protein interaction databases

    BioGridi111765. 3 interactions.
    DIPiDIP-42066N.
    IntActiQ15256. 4 interactions.
    MINTiMINT-1350037.
    STRINGi9606.ENSP00000283228.

    Structurei

    Secondary structure

    1
    657
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi380 – 3867
    Helixi390 – 3989
    Helixi407 – 4093
    Helixi415 – 4184
    Helixi428 – 4303
    Beta strandi431 – 4333
    Helixi442 – 4454
    Beta strandi446 – 4527
    Helixi455 – 4573
    Beta strandi461 – 4655
    Helixi470 – 4723
    Helixi473 – 48311
    Beta strandi487 – 4926
    Beta strandi494 – 4996
    Beta strandi507 – 5126
    Beta strandi515 – 52410
    Beta strandi529 – 5379
    Beta strandi540 – 54910
    Beta strandi554 – 5563
    Helixi562 – 57615
    Beta strandi584 – 5874
    Beta strandi589 – 5924
    Helixi593 – 61119
    Beta strandi612 – 6143
    Helixi616 – 62611
    Helixi634 – 64815

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2A8BX-ray2.30A375-655[»]
    ProteinModelPortaliQ15256.
    SMRiQ15256. Positions 375-655.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ15256.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini22 – 227206ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini249 – 657409CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei228 – 24821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini393 – 647255Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni588 – 5947Substrate bindingBy similarity

    Sequence similaritiesi

    Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG5599.
    HOGENOMiHOG000294188.
    HOVERGENiHBG001594.
    KOiK04458.
    OMAiPIGLQER.
    OrthoDBiEOG7288QX.
    PhylomeDBiQ15256.
    TreeFamiTF331016.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
    [Graphical view]
    PfamiPF00102. Y_phosphatase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF001997. PTPRR. 1 hit.
    PRINTSiPR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTiSM00194. PTPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view]

    Sequences (4)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 4 isoformsi produced by alternative splicing. Align

    Isoform Alpha (identifier: Q15256-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRRAVCFPAL CLLLNLHAAG CFSGNNDHFL AINQKKSGKP VFIYKHSQDI    50
    EKSLDIAPQK IYRHSYHSSS EAQVSKRHQI VNSAFPRPAY DPSLNLLAMD 100
    GQDLEVENLP IPAANVIVVT LQMDVNKLNI TLLRIFRQGV AAALGLLPQQ 150
    VHINRLIGKK NSIELFVSPI NRKTGISDAL PSEEVLRSLN INVLHQSLSQ 200
    FGITEVSPEK NVLQGQHEAD KIWSKEGFYA VVIFLSIFVI IVTCLMILYR 250
    LKERFQLSLR QDKEKNQEIH LSPITLQPAL SEAKTVHSMV QPEQAPKVLN 300
    VVVDPQGRGA PEIKATTATS VCPSPFKMKP IGLQERRGSN VSLTLDMSSL 350
    GNIEPFVSIP TPREKVAMEY LQSASRILTR SQLRDVVASS HLLQSEFMEI 400
    PMNFVDPKEI DIPRHGTKNR YKTILPNPLS RVCLRPKNVT DSLSTYINAN 450
    YIRGYSGKEK AFIATQGPMI NTVDDFWQMV WQEDSPVIVM ITKLKEKNEK 500
    CVLYWPEKRG IYGKVEVLVI SVNECDNYTI RNLVLKQGSH TQHVKHYWYT 550
    SWPDHKTPDS AQPLLQLMLD VEEDRLASQG RGPVVVHCSA GIGRTGCFIA 600
    TSIGCQQLKE EGVVDALSIV CQLRMDRGGM VQTSEQYEFV HHALCLYESR 650
    LSAETVQ 657
    Length:657
    Mass (Da):73,834
    Last modified:March 6, 2007 - v2
    Checksum:i42CD98F37AC5B638
    GO
    Isoform Gamma (identifier: Q15256-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-245: Missing.

    Show »
    Length:412
    Mass (Da):46,581
    Checksum:i92D2900B943CBDBB
    GO
    Isoform Delta (identifier: Q15256-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-206: Missing.
         207-209: SPE → MNQ

    Show »
    Length:451
    Mass (Da):51,046
    Checksum:i7AC02DFE48E42761
    GO
    Isoform 4 (identifier: Q15256-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-7: MRRAVCF → MQSISKQ
         8-119: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:545
    Mass (Da):61,415
    Checksum:i67867697541BC393
    GO

    Sequence cautioni

    The sequence CAA57957.1 differs from that shown. Reason: Frameshift at position 651.
    The sequence CAB01957.1 differs from that shown. Reason: Frameshift at position 651.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti407 – 4071P → S in BAH12227. (PubMed:14702039)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti249 – 2491Y → H.
    Corresponds to variant rs35987017 [ dbSNP | Ensembl ].
    VAR_057140
    Natural varianti314 – 3141K → R.6 Publications
    Corresponds to variant rs3803036 [ dbSNP | Ensembl ].
    VAR_014283
    Natural varianti386 – 3861V → I.
    Corresponds to variant rs35387004 [ dbSNP | Ensembl ].
    VAR_057141
    Natural varianti439 – 4391V → I.
    Corresponds to variant rs35390084 [ dbSNP | Ensembl ].
    VAR_057142

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 245245Missing in isoform Gamma. 1 PublicationVSP_005156Add
    BLAST
    Alternative sequencei1 – 206206Missing in isoform Delta. 1 PublicationVSP_005155Add
    BLAST
    Alternative sequencei1 – 77MRRAVCF → MQSISKQ in isoform 4. 1 PublicationVSP_046352
    Alternative sequencei8 – 119112Missing in isoform 4. 1 PublicationVSP_046353Add
    BLAST
    Alternative sequencei207 – 2093SPE → MNQ in isoform Delta. 1 PublicationVSP_005158

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D64053 mRNA. Translation: BAA10930.1.
    U42361 mRNA. Translation: AAD09447.1.
    U77917 mRNA. Translation: AAB54007.1.
    U77916 mRNA. Translation: AAB54006.1.
    AF263029
    , AF263016, AF263017, AF263018, AF263019, AF263020, AF263021, AF263022, AF263023, AF263024, AF263025, AF263026, AF263027, AF263028 Genomic DNA. Translation: AAG47642.1.
    Z79693 mRNA. Translation: CAB01957.1. Frameshift.
    AK295951 mRNA. Translation: BAH12227.1.
    AK312376 mRNA. Translation: BAG35294.1.
    AC083809 Genomic DNA. No translation available.
    AC084877 Genomic DNA. No translation available.
    AC090676 Genomic DNA. No translation available.
    AC140066 Genomic DNA. No translation available.
    X82635 mRNA. Translation: CAA57957.1. Frameshift.
    CCDSiCCDS44945.1. [Q15256-3]
    CCDS55847.1. [Q15256-4]
    CCDS55848.1. [Q15256-5]
    CCDS8998.1. [Q15256-1]
    RefSeqiNP_001193944.1. NM_001207015.1. [Q15256-5]
    NP_001193945.1. NM_001207016.1. [Q15256-4]
    NP_002840.2. NM_002849.3. [Q15256-1]
    NP_570897.2. NM_130846.2. [Q15256-3]
    UniGeneiHs.506076.

    Genome annotation databases

    EnsembliENST00000283228; ENSP00000283228; ENSG00000153233. [Q15256-1]
    ENST00000342084; ENSP00000339605; ENSG00000153233. [Q15256-5]
    ENST00000378778; ENSP00000368054; ENSG00000153233. [Q15256-4]
    ENST00000440835; ENSP00000391750; ENSG00000153233. [Q15256-3]
    ENST00000549308; ENSP00000446943; ENSG00000153233. [Q15256-3]
    GeneIDi5801.
    KEGGihsa:5801.
    UCSCiuc001swh.2. human. [Q15256-1]
    uc009zrs.3. human. [Q15256-4]

    Polymorphism databases

    DMDMi134039192.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D64053 mRNA. Translation: BAA10930.1 .
    U42361 mRNA. Translation: AAD09447.1 .
    U77917 mRNA. Translation: AAB54007.1 .
    U77916 mRNA. Translation: AAB54006.1 .
    AF263029
    , AF263016 , AF263017 , AF263018 , AF263019 , AF263020 , AF263021 , AF263022 , AF263023 , AF263024 , AF263025 , AF263026 , AF263027 , AF263028 Genomic DNA. Translation: AAG47642.1 .
    Z79693 mRNA. Translation: CAB01957.1 . Frameshift.
    AK295951 mRNA. Translation: BAH12227.1 .
    AK312376 mRNA. Translation: BAG35294.1 .
    AC083809 Genomic DNA. No translation available.
    AC084877 Genomic DNA. No translation available.
    AC090676 Genomic DNA. No translation available.
    AC140066 Genomic DNA. No translation available.
    X82635 mRNA. Translation: CAA57957.1 . Frameshift.
    CCDSi CCDS44945.1. [Q15256-3 ]
    CCDS55847.1. [Q15256-4 ]
    CCDS55848.1. [Q15256-5 ]
    CCDS8998.1. [Q15256-1 ]
    RefSeqi NP_001193944.1. NM_001207015.1. [Q15256-5 ]
    NP_001193945.1. NM_001207016.1. [Q15256-4 ]
    NP_002840.2. NM_002849.3. [Q15256-1 ]
    NP_570897.2. NM_130846.2. [Q15256-3 ]
    UniGenei Hs.506076.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2A8B X-ray 2.30 A 375-655 [» ]
    ProteinModelPortali Q15256.
    SMRi Q15256. Positions 375-655.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111765. 3 interactions.
    DIPi DIP-42066N.
    IntActi Q15256. 4 interactions.
    MINTi MINT-1350037.
    STRINGi 9606.ENSP00000283228.

    PTM databases

    PhosphoSitei Q15256.

    Polymorphism databases

    DMDMi 134039192.

    Proteomic databases

    MaxQBi Q15256.
    PaxDbi Q15256.
    PRIDEi Q15256.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000283228 ; ENSP00000283228 ; ENSG00000153233 . [Q15256-1 ]
    ENST00000342084 ; ENSP00000339605 ; ENSG00000153233 . [Q15256-5 ]
    ENST00000378778 ; ENSP00000368054 ; ENSG00000153233 . [Q15256-4 ]
    ENST00000440835 ; ENSP00000391750 ; ENSG00000153233 . [Q15256-3 ]
    ENST00000549308 ; ENSP00000446943 ; ENSG00000153233 . [Q15256-3 ]
    GeneIDi 5801.
    KEGGi hsa:5801.
    UCSCi uc001swh.2. human. [Q15256-1 ]
    uc009zrs.3. human. [Q15256-4 ]

    Organism-specific databases

    CTDi 5801.
    GeneCardsi GC12M071031.
    HGNCi HGNC:9680. PTPRR.
    HPAi CAB011461.
    HPA011851.
    MIMi 602853. gene.
    neXtProti NX_Q15256.
    PharmGKBi PA34025.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5599.
    HOGENOMi HOG000294188.
    HOVERGENi HBG001594.
    KOi K04458.
    OMAi PIGLQER.
    OrthoDBi EOG7288QX.
    PhylomeDBi Q15256.
    TreeFami TF331016.

    Enzyme and pathway databases

    BRENDAi 3.1.3.48. 2681.

    Miscellaneous databases

    EvolutionaryTracei Q15256.
    GeneWikii PTPRR.
    GenomeRNAii 5801.
    NextBioi 22606.
    PROi Q15256.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15256.
    Bgeei Q15256.
    CleanExi HS_PTPRQ.
    HS_PTPRR.
    Genevestigatori Q15256.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    IPR016130. Tyr_Pase_AS.
    IPR008356. Tyr_Pase_KIM-con.
    IPR000242. Tyr_Pase_rcpt/non-rcpt.
    IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
    [Graphical view ]
    Pfami PF00102. Y_phosphatase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF001997. PTPRR. 1 hit.
    PRINTSi PR01778. KIMPTPASE.
    PR00700. PRTYPHPHTASE.
    SMARTi SM00194. PTPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
    PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase."
      Shiozuka K., Watanabe Y., Ikeda T., Hashimoto S., Kawashima H.
      Gene 162:279-284(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT ARG-314.
      Tissue: Brain.
    2. "Protein tyrosine phosphatase (PC12, Br7,Sl) family: expression characterization in the adult human and mouse."
      Augustine K.A., Silbiger S.M., Bucay N., Ulias L., Boynton A., Trebasky L.D., Medlock E.S.
      Anat. Rec. 258:221-234(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; GAMMA AND DELTA), TISSUE SPECIFICITY, VARIANT ARG-314.
      Tissue: Brain and Colon.
    3. "Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes."
      Bektas A., Hughes J.N., Warram J.H., Krolewski A.S., Doria A.
      Diabetes 50:204-208(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-314.
    4. "Cloning and characterization of novel PTP (NC-PTPCOM) from neuronal cells."
      Knyazev P., Cheburkin Y., Knyazev Y., Ullrich A.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT ARG-314.
      Tissue: Neuroblastoma.
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND 4), VARIANT ARG-314.
      Tissue: Amygdala and Substantia nigra.
    6. "The finished DNA sequence of human chromosome 12."
      Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
      , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
      Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Molecular cloning and characterization of human epithelial cells specific protein tyrosine phosphatase (EC-PTP)."
      Knyazev P.G., Ullrich A.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 289-657 (ISOFORM ALPHA), VARIANT ARG-314.
      Tissue: Mammary gland.
    8. "Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases."
      Eswaran J., von Kries J.P., Marsden B., Longman E., Debreczeni J.E., Ugochukwu E., Turnbull A., Lee W.H., Knapp S., Barr A.J.
      Biochem. J. 395:483-491(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 375-655.

    Entry informationi

    Entry nameiPTPRR_HUMAN
    AccessioniPrimary (citable) accession number: Q15256
    Secondary accession number(s): B2R5Z7
    , B7Z3J1, F5GXR7, O00342, Q92682, Q9UE65
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 15, 2002
    Last sequence update: March 6, 2007
    Last modified: October 1, 2014
    This is version 142 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3