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Q15256

- PTPRR_HUMAN

UniProt

Q15256 - PTPRR_HUMAN

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Protein

Receptor-type tyrosine-protein phosphatase R

Gene

PTPRR

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei554 – 5541SubstrateBy similarity
Active sitei588 – 5881Phosphocysteine intermediatePROSITE-ProRule annotation
Binding sitei632 – 6321SubstrateBy similarity

GO - Molecular functioni

  1. protein kinase binding Source: UniProtKB
  2. protein tyrosine phosphatase activity Source: ProtInc
  3. transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  1. ERBB2 signaling pathway Source: UniProtKB
  2. in utero embryonic development Source: UniProtKB
  3. negative regulation of epithelial cell migration Source: UniProtKB
  4. negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
  5. peptidyl-tyrosine dephosphorylation Source: GOC
  6. protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BRENDAi3.1.3.48. 2681.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase R (EC:3.1.3.48)
Short name:
R-PTP-R
Alternative name(s):
Ch-1PTPase
NC-PTPCOM1
Protein-tyrosine phosphatase PCPTP1
Gene namesi
Name:PTPRR
Synonyms:ECPTP, PTPRQ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:9680. PTPRR.

Subcellular locationi

Isoform Delta : Cytoplasmperinuclear region
Note: Locates to the perinuclear areas within the cytoplasm.
Isoform Gamma : Cytoplasmperinuclear region
Note: Locates to the perinuclear areas within the cytoplasm.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. extracellular space Source: UniProt
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34025.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 657636Receptor-type tyrosine-protein phosphatase RPRO_0000025459Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi129 – 1291N-linked (GlcNAc...)Sequence Analysis
Modified residuei339 – 3391Phosphoserine; by PKABy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ15256.
PaxDbiQ15256.
PRIDEiQ15256.

PTM databases

PhosphoSiteiQ15256.

Expressioni

Tissue specificityi

Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.1 Publication

Gene expression databases

BgeeiQ15256.
CleanExiHS_PTPRQ.
HS_PTPRR.
ExpressionAtlasiQ15256. baseline and differential.
GenevestigatoriQ15256.

Organism-specific databases

HPAiCAB011461.
HPA011851.

Interactioni

Subunit structurei

Interacts with MAPKs.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAPK1P284823EBI-2265659,EBI-959949
MAPK14Q165393EBI-2265659,EBI-73946

Protein-protein interaction databases

BioGridi111765. 4 interactions.
DIPiDIP-42066N.
IntActiQ15256. 4 interactions.
MINTiMINT-1350037.
STRINGi9606.ENSP00000283228.

Structurei

Secondary structure

1
657
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi380 – 3867
Helixi390 – 3989
Helixi407 – 4093
Helixi415 – 4184
Helixi428 – 4303
Beta strandi431 – 4333
Helixi442 – 4454
Beta strandi446 – 4527
Helixi455 – 4573
Beta strandi461 – 4655
Helixi470 – 4723
Helixi473 – 48311
Beta strandi487 – 4926
Beta strandi494 – 4996
Beta strandi507 – 5126
Beta strandi515 – 52410
Beta strandi529 – 5379
Beta strandi540 – 54910
Beta strandi554 – 5563
Helixi562 – 57615
Beta strandi584 – 5874
Beta strandi589 – 5924
Helixi593 – 61119
Beta strandi612 – 6143
Helixi616 – 62611
Helixi634 – 64815

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2A8BX-ray2.30A375-655[»]
ProteinModelPortaliQ15256.
SMRiQ15256. Positions 375-655.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15256.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini22 – 227206ExtracellularSequence AnalysisAdd
BLAST
Topological domaini249 – 657409CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei228 – 24821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini393 – 647255Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni588 – 5947Substrate bindingBy similarity

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG5599.
GeneTreeiENSGT00750000117606.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiQ15256.
KOiK04458.
OMAiPIGLQER.
OrthoDBiEOG7288QX.
PhylomeDBiQ15256.
TreeFamiTF331016.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF001997. PTPRR. 1 hit.
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Isoform Alpha (identifier: Q15256-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRAVCFPAL CLLLNLHAAG CFSGNNDHFL AINQKKSGKP VFIYKHSQDI
60 70 80 90 100
EKSLDIAPQK IYRHSYHSSS EAQVSKRHQI VNSAFPRPAY DPSLNLLAMD
110 120 130 140 150
GQDLEVENLP IPAANVIVVT LQMDVNKLNI TLLRIFRQGV AAALGLLPQQ
160 170 180 190 200
VHINRLIGKK NSIELFVSPI NRKTGISDAL PSEEVLRSLN INVLHQSLSQ
210 220 230 240 250
FGITEVSPEK NVLQGQHEAD KIWSKEGFYA VVIFLSIFVI IVTCLMILYR
260 270 280 290 300
LKERFQLSLR QDKEKNQEIH LSPITLQPAL SEAKTVHSMV QPEQAPKVLN
310 320 330 340 350
VVVDPQGRGA PEIKATTATS VCPSPFKMKP IGLQERRGSN VSLTLDMSSL
360 370 380 390 400
GNIEPFVSIP TPREKVAMEY LQSASRILTR SQLRDVVASS HLLQSEFMEI
410 420 430 440 450
PMNFVDPKEI DIPRHGTKNR YKTILPNPLS RVCLRPKNVT DSLSTYINAN
460 470 480 490 500
YIRGYSGKEK AFIATQGPMI NTVDDFWQMV WQEDSPVIVM ITKLKEKNEK
510 520 530 540 550
CVLYWPEKRG IYGKVEVLVI SVNECDNYTI RNLVLKQGSH TQHVKHYWYT
560 570 580 590 600
SWPDHKTPDS AQPLLQLMLD VEEDRLASQG RGPVVVHCSA GIGRTGCFIA
610 620 630 640 650
TSIGCQQLKE EGVVDALSIV CQLRMDRGGM VQTSEQYEFV HHALCLYESR

LSAETVQ
Length:657
Mass (Da):73,834
Last modified:March 6, 2007 - v2
Checksum:i42CD98F37AC5B638
GO
Isoform Gamma (identifier: Q15256-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Show »
Length:412
Mass (Da):46,581
Checksum:i92D2900B943CBDBB
GO
Isoform Delta (identifier: Q15256-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-206: Missing.
     207-209: SPE → MNQ

Show »
Length:451
Mass (Da):51,046
Checksum:i7AC02DFE48E42761
GO
Isoform 4 (identifier: Q15256-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRRAVCF → MQSISKQ
     8-119: Missing.

Note: No experimental confirmation available.

Show »
Length:545
Mass (Da):61,415
Checksum:i67867697541BC393
GO

Sequence cautioni

The sequence CAA57957.1 differs from that shown. Reason: Frameshift at position 651.
The sequence CAB01957.1 differs from that shown. Reason: Frameshift at position 651.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti407 – 4071P → S in BAH12227. (PubMed:14702039)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti249 – 2491Y → H.
Corresponds to variant rs35987017 [ dbSNP | Ensembl ].
VAR_057140
Natural varianti314 – 3141K → R.6 Publications
Corresponds to variant rs3803036 [ dbSNP | Ensembl ].
VAR_014283
Natural varianti386 – 3861V → I.
Corresponds to variant rs35387004 [ dbSNP | Ensembl ].
VAR_057141
Natural varianti439 – 4391V → I.
Corresponds to variant rs35390084 [ dbSNP | Ensembl ].
VAR_057142

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 245245Missing in isoform Gamma. 1 PublicationVSP_005156Add
BLAST
Alternative sequencei1 – 206206Missing in isoform Delta. 1 PublicationVSP_005155Add
BLAST
Alternative sequencei1 – 77MRRAVCF → MQSISKQ in isoform 4. 1 PublicationVSP_046352
Alternative sequencei8 – 119112Missing in isoform 4. 1 PublicationVSP_046353Add
BLAST
Alternative sequencei207 – 2093SPE → MNQ in isoform Delta. 1 PublicationVSP_005158

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64053 mRNA. Translation: BAA10930.1.
U42361 mRNA. Translation: AAD09447.1.
U77917 mRNA. Translation: AAB54007.1.
U77916 mRNA. Translation: AAB54006.1.
AF263029
, AF263016, AF263017, AF263018, AF263019, AF263020, AF263021, AF263022, AF263023, AF263024, AF263025, AF263026, AF263027, AF263028 Genomic DNA. Translation: AAG47642.1.
Z79693 mRNA. Translation: CAB01957.1. Frameshift.
AK295951 mRNA. Translation: BAH12227.1.
AK312376 mRNA. Translation: BAG35294.1.
AC083809 Genomic DNA. No translation available.
AC084877 Genomic DNA. No translation available.
AC090676 Genomic DNA. No translation available.
AC140066 Genomic DNA. No translation available.
X82635 mRNA. Translation: CAA57957.1. Frameshift.
CCDSiCCDS44945.1. [Q15256-3]
CCDS55847.1. [Q15256-4]
CCDS55848.1. [Q15256-5]
CCDS8998.1. [Q15256-1]
RefSeqiNP_001193944.1. NM_001207015.1. [Q15256-5]
NP_001193945.1. NM_001207016.1. [Q15256-4]
NP_002840.2. NM_002849.3. [Q15256-1]
NP_570897.2. NM_130846.2. [Q15256-3]
UniGeneiHs.506076.

Genome annotation databases

EnsembliENST00000283228; ENSP00000283228; ENSG00000153233. [Q15256-1]
ENST00000342084; ENSP00000339605; ENSG00000153233. [Q15256-5]
ENST00000378778; ENSP00000368054; ENSG00000153233. [Q15256-4]
ENST00000440835; ENSP00000391750; ENSG00000153233. [Q15256-3]
ENST00000549308; ENSP00000446943; ENSG00000153233. [Q15256-3]
GeneIDi5801.
KEGGihsa:5801.
UCSCiuc001swh.2. human. [Q15256-1]
uc009zrs.3. human. [Q15256-4]

Polymorphism databases

DMDMi134039192.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D64053 mRNA. Translation: BAA10930.1 .
U42361 mRNA. Translation: AAD09447.1 .
U77917 mRNA. Translation: AAB54007.1 .
U77916 mRNA. Translation: AAB54006.1 .
AF263029
, AF263016 , AF263017 , AF263018 , AF263019 , AF263020 , AF263021 , AF263022 , AF263023 , AF263024 , AF263025 , AF263026 , AF263027 , AF263028 Genomic DNA. Translation: AAG47642.1 .
Z79693 mRNA. Translation: CAB01957.1 . Frameshift.
AK295951 mRNA. Translation: BAH12227.1 .
AK312376 mRNA. Translation: BAG35294.1 .
AC083809 Genomic DNA. No translation available.
AC084877 Genomic DNA. No translation available.
AC090676 Genomic DNA. No translation available.
AC140066 Genomic DNA. No translation available.
X82635 mRNA. Translation: CAA57957.1 . Frameshift.
CCDSi CCDS44945.1. [Q15256-3 ]
CCDS55847.1. [Q15256-4 ]
CCDS55848.1. [Q15256-5 ]
CCDS8998.1. [Q15256-1 ]
RefSeqi NP_001193944.1. NM_001207015.1. [Q15256-5 ]
NP_001193945.1. NM_001207016.1. [Q15256-4 ]
NP_002840.2. NM_002849.3. [Q15256-1 ]
NP_570897.2. NM_130846.2. [Q15256-3 ]
UniGenei Hs.506076.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2A8B X-ray 2.30 A 375-655 [» ]
ProteinModelPortali Q15256.
SMRi Q15256. Positions 375-655.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111765. 4 interactions.
DIPi DIP-42066N.
IntActi Q15256. 4 interactions.
MINTi MINT-1350037.
STRINGi 9606.ENSP00000283228.

PTM databases

PhosphoSitei Q15256.

Polymorphism databases

DMDMi 134039192.

Proteomic databases

MaxQBi Q15256.
PaxDbi Q15256.
PRIDEi Q15256.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000283228 ; ENSP00000283228 ; ENSG00000153233 . [Q15256-1 ]
ENST00000342084 ; ENSP00000339605 ; ENSG00000153233 . [Q15256-5 ]
ENST00000378778 ; ENSP00000368054 ; ENSG00000153233 . [Q15256-4 ]
ENST00000440835 ; ENSP00000391750 ; ENSG00000153233 . [Q15256-3 ]
ENST00000549308 ; ENSP00000446943 ; ENSG00000153233 . [Q15256-3 ]
GeneIDi 5801.
KEGGi hsa:5801.
UCSCi uc001swh.2. human. [Q15256-1 ]
uc009zrs.3. human. [Q15256-4 ]

Organism-specific databases

CTDi 5801.
GeneCardsi GC12M071031.
HGNCi HGNC:9680. PTPRR.
HPAi CAB011461.
HPA011851.
MIMi 602853. gene.
neXtProti NX_Q15256.
PharmGKBi PA34025.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5599.
GeneTreei ENSGT00750000117606.
HOGENOMi HOG000294188.
HOVERGENi HBG001594.
InParanoidi Q15256.
KOi K04458.
OMAi PIGLQER.
OrthoDBi EOG7288QX.
PhylomeDBi Q15256.
TreeFami TF331016.

Enzyme and pathway databases

BRENDAi 3.1.3.48. 2681.

Miscellaneous databases

EvolutionaryTracei Q15256.
GeneWikii PTPRR.
GenomeRNAii 5801.
NextBioi 22606.
PROi Q15256.
SOURCEi Search...

Gene expression databases

Bgeei Q15256.
CleanExi HS_PTPRQ.
HS_PTPRR.
ExpressionAtlasi Q15256. baseline and differential.
Genevestigatori Q15256.

Family and domain databases

Gene3Di 3.90.190.10. 1 hit.
InterProi IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
[Graphical view ]
Pfami PF00102. Y_phosphatase. 1 hit.
[Graphical view ]
PIRSFi PIRSF001997. PTPRR. 1 hit.
PRINTSi PR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTi SM00194. PTPc. 1 hit.
[Graphical view ]
SUPFAMi SSF52799. SSF52799. 1 hit.
PROSITEi PS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase."
    Shiozuka K., Watanabe Y., Ikeda T., Hashimoto S., Kawashima H.
    Gene 162:279-284(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT ARG-314.
    Tissue: Brain.
  2. "Protein tyrosine phosphatase (PC12, Br7,Sl) family: expression characterization in the adult human and mouse."
    Augustine K.A., Silbiger S.M., Bucay N., Ulias L., Boynton A., Trebasky L.D., Medlock E.S.
    Anat. Rec. 258:221-234(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; GAMMA AND DELTA), TISSUE SPECIFICITY, VARIANT ARG-314.
    Tissue: Brain and Colon.
  3. "Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes."
    Bektas A., Hughes J.N., Warram J.H., Krolewski A.S., Doria A.
    Diabetes 50:204-208(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-314.
  4. "Cloning and characterization of novel PTP (NC-PTPCOM) from neuronal cells."
    Knyazev P., Cheburkin Y., Knyazev Y., Ullrich A.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT ARG-314.
    Tissue: Neuroblastoma.
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND 4), VARIANT ARG-314.
    Tissue: Amygdala and Substantia nigra.
  6. "The finished DNA sequence of human chromosome 12."
    Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R.
    , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
    Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Molecular cloning and characterization of human epithelial cells specific protein tyrosine phosphatase (EC-PTP)."
    Knyazev P.G., Ullrich A.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 289-657 (ISOFORM ALPHA), VARIANT ARG-314.
    Tissue: Mammary gland.
  8. "Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases."
    Eswaran J., von Kries J.P., Marsden B., Longman E., Debreczeni J.E., Ugochukwu E., Turnbull A., Lee W.H., Knapp S., Barr A.J.
    Biochem. J. 395:483-491(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 375-655.

Entry informationi

Entry nameiPTPRR_HUMAN
AccessioniPrimary (citable) accession number: Q15256
Secondary accession number(s): B2R5Z7
, B7Z3J1, F5GXR7, O00342, Q92682, Q9UE65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 6, 2007
Last modified: October 29, 2014
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3