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Protein

Receptor-type tyrosine-protein phosphatase R

Gene

PTPRR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus (By similarity).By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei554SubstrateBy similarity1
Active sitei588Phosphocysteine intermediatePROSITE-ProRule annotation1
Binding sitei632SubstrateBy similarity1

GO - Molecular functioni

  • protein kinase binding Source: UniProtKB
  • protein tyrosine phosphatase activity Source: ProtInc
  • transmembrane receptor protein tyrosine phosphatase activity Source: ProtInc

GO - Biological processi

  • ERBB2 signaling pathway Source: UniProtKB
  • in utero embryonic development Source: UniProtKB
  • negative regulation of epithelial cell migration Source: UniProtKB
  • negative regulation of ERK1 and ERK2 cascade Source: UniProtKB
  • protein dephosphorylation Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase, Receptor

Enzyme and pathway databases

BioCyciZFISH:HS07894-MONOMER.
BRENDAi3.1.3.48. 2681.
SIGNORiQ15256.

Names & Taxonomyi

Protein namesi
Recommended name:
Receptor-type tyrosine-protein phosphatase R (EC:3.1.3.48)
Short name:
R-PTP-R
Alternative name(s):
Ch-1PTPase
NC-PTPCOM1
Protein-tyrosine phosphatase PCPTP1
Gene namesi
Name:PTPRR
Synonyms:ECPTP, PTPRQ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:9680. PTPRR.

Subcellular locationi

Isoform Delta :
Isoform Gamma :

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 227ExtracellularSequence analysisAdd BLAST206
Transmembranei228 – 248HelicalSequence analysisAdd BLAST21
Topological domaini249 – 657CytoplasmicSequence analysisAdd BLAST409

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5801.
OpenTargetsiENSG00000153233.
PharmGKBiPA34025.

Chemistry databases

ChEMBLiCHEMBL3425390.

Polymorphism and mutation databases

BioMutaiPTPRR.
DMDMi134039192.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000002545922 – 657Receptor-type tyrosine-protein phosphatase RAdd BLAST636

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi129N-linked (GlcNAc...)Sequence analysis1
Modified residuei272PhosphoserineBy similarity1
Modified residuei339Phosphoserine; by PKABy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ15256.
PaxDbiQ15256.
PeptideAtlasiQ15256.
PRIDEiQ15256.

PTM databases

DEPODiQ15256.
iPTMnetiQ15256.
PhosphoSitePlusiQ15256.

Expressioni

Tissue specificityi

Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alpha has been observed only in the brain. Isoform gamma is expressed in brain, placenta and uterus. Isoform delta is expressed in brain, kidney, placenta, prostate, small intestine and uterus.1 Publication

Gene expression databases

BgeeiENSG00000153233.
CleanExiHS_PTPRQ.
HS_PTPRR.
ExpressionAtlasiQ15256. baseline and differential.
GenevisibleiQ15256. HS.

Organism-specific databases

HPAiCAB011461.
HPA011851.
HPA071067.

Interactioni

Subunit structurei

Interacts with MAPKs.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
MAPK1P284823EBI-2265659,EBI-959949
MAPK14Q165393EBI-2265659,EBI-73946

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111765. 6 interactors.
DIPiDIP-42066N.
IntActiQ15256. 4 interactors.
MINTiMINT-1350037.
STRINGi9606.ENSP00000283228.

Chemistry databases

BindingDBiQ15256.

Structurei

Secondary structure

1657
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi380 – 386Combined sources7
Helixi390 – 398Combined sources9
Helixi407 – 409Combined sources3
Helixi415 – 418Combined sources4
Helixi428 – 430Combined sources3
Beta strandi431 – 433Combined sources3
Helixi442 – 445Combined sources4
Beta strandi446 – 452Combined sources7
Helixi455 – 457Combined sources3
Beta strandi461 – 465Combined sources5
Helixi470 – 472Combined sources3
Helixi473 – 483Combined sources11
Beta strandi487 – 492Combined sources6
Beta strandi494 – 499Combined sources6
Beta strandi507 – 512Combined sources6
Beta strandi515 – 524Combined sources10
Beta strandi529 – 537Combined sources9
Beta strandi540 – 549Combined sources10
Beta strandi554 – 556Combined sources3
Helixi562 – 576Combined sources15
Beta strandi584 – 587Combined sources4
Beta strandi589 – 592Combined sources4
Helixi593 – 611Combined sources19
Beta strandi612 – 614Combined sources3
Helixi616 – 626Combined sources11
Helixi634 – 648Combined sources15

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A8BX-ray2.30A375-655[»]
ProteinModelPortaliQ15256.
SMRiQ15256.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ15256.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini393 – 647Tyrosine-protein phosphatasePROSITE-ProRule annotationAdd BLAST255

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni588 – 594Substrate bindingBy similarity7

Sequence similaritiesi

Contains 1 tyrosine-protein phosphatase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiQ15256.
KOiK04458.
OMAiCLMILYR.
OrthoDBiEOG091G0HLB.
PhylomeDBiQ15256.
TreeFamiTF331016.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR008356. Tyr_Pase_KIM-con.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF001997. PTPRR. 1 hit.
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Alpha (identifier: Q15256-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRRAVCFPAL CLLLNLHAAG CFSGNNDHFL AINQKKSGKP VFIYKHSQDI
60 70 80 90 100
EKSLDIAPQK IYRHSYHSSS EAQVSKRHQI VNSAFPRPAY DPSLNLLAMD
110 120 130 140 150
GQDLEVENLP IPAANVIVVT LQMDVNKLNI TLLRIFRQGV AAALGLLPQQ
160 170 180 190 200
VHINRLIGKK NSIELFVSPI NRKTGISDAL PSEEVLRSLN INVLHQSLSQ
210 220 230 240 250
FGITEVSPEK NVLQGQHEAD KIWSKEGFYA VVIFLSIFVI IVTCLMILYR
260 270 280 290 300
LKERFQLSLR QDKEKNQEIH LSPITLQPAL SEAKTVHSMV QPEQAPKVLN
310 320 330 340 350
VVVDPQGRGA PEIKATTATS VCPSPFKMKP IGLQERRGSN VSLTLDMSSL
360 370 380 390 400
GNIEPFVSIP TPREKVAMEY LQSASRILTR SQLRDVVASS HLLQSEFMEI
410 420 430 440 450
PMNFVDPKEI DIPRHGTKNR YKTILPNPLS RVCLRPKNVT DSLSTYINAN
460 470 480 490 500
YIRGYSGKEK AFIATQGPMI NTVDDFWQMV WQEDSPVIVM ITKLKEKNEK
510 520 530 540 550
CVLYWPEKRG IYGKVEVLVI SVNECDNYTI RNLVLKQGSH TQHVKHYWYT
560 570 580 590 600
SWPDHKTPDS AQPLLQLMLD VEEDRLASQG RGPVVVHCSA GIGRTGCFIA
610 620 630 640 650
TSIGCQQLKE EGVVDALSIV CQLRMDRGGM VQTSEQYEFV HHALCLYESR

LSAETVQ
Length:657
Mass (Da):73,834
Last modified:March 6, 2007 - v2
Checksum:i42CD98F37AC5B638
GO
Isoform Gamma (identifier: Q15256-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.

Show »
Length:412
Mass (Da):46,581
Checksum:i92D2900B943CBDBB
GO
Isoform Delta (identifier: Q15256-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-206: Missing.
     207-209: SPE → MNQ

Show »
Length:451
Mass (Da):51,046
Checksum:i7AC02DFE48E42761
GO
Isoform 4 (identifier: Q15256-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRRAVCF → MQSISKQ
     8-119: Missing.

Note: No experimental confirmation available.
Show »
Length:545
Mass (Da):61,415
Checksum:i67867697541BC393
GO

Sequence cautioni

The sequence CAA57957 differs from that shown. Reason: Frameshift at position 651.Curated
The sequence CAB01957 differs from that shown. Reason: Frameshift at position 651.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti407P → S in BAH12227 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_057140249Y → H.Corresponds to variant rs35987017dbSNPEnsembl.1
Natural variantiVAR_014283314K → R.6 PublicationsCorresponds to variant rs3803036dbSNPEnsembl.1
Natural variantiVAR_057141386V → I.Corresponds to variant rs35387004dbSNPEnsembl.1
Natural variantiVAR_057142439V → I.Corresponds to variant rs35390084dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0051561 – 245Missing in isoform Gamma. 1 PublicationAdd BLAST245
Alternative sequenceiVSP_0051551 – 206Missing in isoform Delta. 1 PublicationAdd BLAST206
Alternative sequenceiVSP_0463521 – 7MRRAVCF → MQSISKQ in isoform 4. 1 Publication7
Alternative sequenceiVSP_0463538 – 119Missing in isoform 4. 1 PublicationAdd BLAST112
Alternative sequenceiVSP_005158207 – 209SPE → MNQ in isoform Delta. 1 Publication3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64053 mRNA. Translation: BAA10930.1.
U42361 mRNA. Translation: AAD09447.1.
U77917 mRNA. Translation: AAB54007.1.
U77916 mRNA. Translation: AAB54006.1.
AF263029
, AF263016, AF263017, AF263018, AF263019, AF263020, AF263021, AF263022, AF263023, AF263024, AF263025, AF263026, AF263027, AF263028 Genomic DNA. Translation: AAG47642.1.
Z79693 mRNA. Translation: CAB01957.1. Frameshift.
AK295951 mRNA. Translation: BAH12227.1.
AK312376 mRNA. Translation: BAG35294.1.
AC083809 Genomic DNA. No translation available.
AC084877 Genomic DNA. No translation available.
AC090676 Genomic DNA. No translation available.
AC140066 Genomic DNA. No translation available.
X82635 mRNA. Translation: CAA57957.1. Frameshift.
CCDSiCCDS44945.1. [Q15256-3]
CCDS55847.1. [Q15256-4]
CCDS55848.1. [Q15256-5]
CCDS8998.1. [Q15256-1]
RefSeqiNP_001193944.1. NM_001207015.1. [Q15256-5]
NP_001193945.1. NM_001207016.1. [Q15256-4]
NP_002840.2. NM_002849.3. [Q15256-1]
NP_570897.2. NM_130846.2. [Q15256-3]
UniGeneiHs.506076.

Genome annotation databases

EnsembliENST00000283228; ENSP00000283228; ENSG00000153233. [Q15256-1]
ENST00000342084; ENSP00000339605; ENSG00000153233. [Q15256-5]
ENST00000378778; ENSP00000368054; ENSG00000153233. [Q15256-4]
ENST00000440835; ENSP00000391750; ENSG00000153233. [Q15256-3]
ENST00000549308; ENSP00000446943; ENSG00000153233. [Q15256-3]
GeneIDi5801.
KEGGihsa:5801.
UCSCiuc001swh.3. human. [Q15256-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D64053 mRNA. Translation: BAA10930.1.
U42361 mRNA. Translation: AAD09447.1.
U77917 mRNA. Translation: AAB54007.1.
U77916 mRNA. Translation: AAB54006.1.
AF263029
, AF263016, AF263017, AF263018, AF263019, AF263020, AF263021, AF263022, AF263023, AF263024, AF263025, AF263026, AF263027, AF263028 Genomic DNA. Translation: AAG47642.1.
Z79693 mRNA. Translation: CAB01957.1. Frameshift.
AK295951 mRNA. Translation: BAH12227.1.
AK312376 mRNA. Translation: BAG35294.1.
AC083809 Genomic DNA. No translation available.
AC084877 Genomic DNA. No translation available.
AC090676 Genomic DNA. No translation available.
AC140066 Genomic DNA. No translation available.
X82635 mRNA. Translation: CAA57957.1. Frameshift.
CCDSiCCDS44945.1. [Q15256-3]
CCDS55847.1. [Q15256-4]
CCDS55848.1. [Q15256-5]
CCDS8998.1. [Q15256-1]
RefSeqiNP_001193944.1. NM_001207015.1. [Q15256-5]
NP_001193945.1. NM_001207016.1. [Q15256-4]
NP_002840.2. NM_002849.3. [Q15256-1]
NP_570897.2. NM_130846.2. [Q15256-3]
UniGeneiHs.506076.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A8BX-ray2.30A375-655[»]
ProteinModelPortaliQ15256.
SMRiQ15256.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111765. 6 interactors.
DIPiDIP-42066N.
IntActiQ15256. 4 interactors.
MINTiMINT-1350037.
STRINGi9606.ENSP00000283228.

Chemistry databases

BindingDBiQ15256.
ChEMBLiCHEMBL3425390.

PTM databases

DEPODiQ15256.
iPTMnetiQ15256.
PhosphoSitePlusiQ15256.

Polymorphism and mutation databases

BioMutaiPTPRR.
DMDMi134039192.

Proteomic databases

MaxQBiQ15256.
PaxDbiQ15256.
PeptideAtlasiQ15256.
PRIDEiQ15256.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000283228; ENSP00000283228; ENSG00000153233. [Q15256-1]
ENST00000342084; ENSP00000339605; ENSG00000153233. [Q15256-5]
ENST00000378778; ENSP00000368054; ENSG00000153233. [Q15256-4]
ENST00000440835; ENSP00000391750; ENSG00000153233. [Q15256-3]
ENST00000549308; ENSP00000446943; ENSG00000153233. [Q15256-3]
GeneIDi5801.
KEGGihsa:5801.
UCSCiuc001swh.3. human. [Q15256-1]

Organism-specific databases

CTDi5801.
DisGeNETi5801.
GeneCardsiPTPRR.
HGNCiHGNC:9680. PTPRR.
HPAiCAB011461.
HPA011851.
HPA071067.
MIMi602853. gene.
neXtProtiNX_Q15256.
OpenTargetsiENSG00000153233.
PharmGKBiPA34025.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0789. Eukaryota.
COG5599. LUCA.
GeneTreeiENSGT00770000120452.
HOGENOMiHOG000294188.
HOVERGENiHBG001594.
InParanoidiQ15256.
KOiK04458.
OMAiCLMILYR.
OrthoDBiEOG091G0HLB.
PhylomeDBiQ15256.
TreeFamiTF331016.

Enzyme and pathway databases

BioCyciZFISH:HS07894-MONOMER.
BRENDAi3.1.3.48. 2681.
SIGNORiQ15256.

Miscellaneous databases

EvolutionaryTraceiQ15256.
GeneWikiiPTPRR.
GenomeRNAii5801.
PROiQ15256.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000153233.
CleanExiHS_PTPRQ.
HS_PTPRR.
ExpressionAtlasiQ15256. baseline and differential.
GenevisibleiQ15256. HS.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR029021. Prot-tyrosine_phosphatase-like.
IPR000242. PTPase_domain.
IPR016130. Tyr_Pase_AS.
IPR003595. Tyr_Pase_cat.
IPR008356. Tyr_Pase_KIM-con.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
IPR000387. TYR_PHOSPHATASE_dom.
[Graphical view]
PfamiPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFiPIRSF001997. PTPRR. 1 hit.
PRINTSiPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTiSM00194. PTPc. 1 hit.
SM00404. PTPc_motif. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTPRR_HUMAN
AccessioniPrimary (citable) accession number: Q15256
Secondary accession number(s): B2R5Z7
, B7Z3J1, F5GXR7, O00342, Q92682, Q9UE65
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 6, 2007
Last modified: November 30, 2016
This is version 164 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.