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Q15256 (PTPRR_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Receptor-type tyrosine-protein phosphatase R

Short name=R-PTP-R
EC=3.1.3.48
Alternative name(s):
Ch-1PTPase
NC-PTPCOM1
Protein-tyrosine phosphatase PCPTP1
Gene names
Name:PTPRR
Synonyms:ECPTP, PTPRQ
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length657 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

Subunit structure

Interacts with MAPKs By similarity.

Subcellular location

Isoform Alpha: Cell membrane; Single-pass type I membrane protein.

Isoform Delta: Cytoplasmperinuclear region. Note: Locates to the perinuclear areas within the cytoplasm.

Isoform Gamma: Cytoplasmperinuclear region. Note: Locates to the perinuclear areas within the cytoplasm.

Tissue specificity

Expressed in brain, placenta, small intestine, stomach, uterus and weakly in the prostate. Isoform alphahas been observed only in the brain. Isoform gammais expressed in brain, placenta and uterus. Isoform deltais expressed in brain, kidney, placenta, prostate, small intestine and uterus. Ref.2

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Receptor class 7 subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence caution

The sequence CAA57957.1 differs from that shown. Reason: Frameshift at position 651.

The sequence CAB01957.1 differs from that shown. Reason: Frameshift at position 651.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MAPK14Q165393EBI-2265659,EBI-73946

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform Alpha (identifier: Q15256-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform Gamma (identifier: Q15256-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-245: Missing.
Isoform Delta (identifier: Q15256-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-206: Missing.
     207-209: SPE → MNQ
Isoform 4 (identifier: Q15256-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-7: MRRAVCF → MQSISKQ
     8-119: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2121 Potential
Chain22 – 657636Receptor-type tyrosine-protein phosphatase R
PRO_0000025459

Regions

Topological domain22 – 227206Extracellular Potential
Transmembrane228 – 24821Helical; Potential
Topological domain249 – 657409Cytoplasmic Potential
Domain393 – 647255Tyrosine-protein phosphatase
Region588 – 5947Substrate binding By similarity

Sites

Active site5881Phosphocysteine intermediate By similarity
Binding site5541Substrate By similarity
Binding site6321Substrate By similarity

Amino acid modifications

Modified residue3391Phosphoserine; by PKA By similarity
Glycosylation1291N-linked (GlcNAc...) Potential

Natural variations

Alternative sequence1 – 245245Missing in isoform Gamma.
VSP_005156
Alternative sequence1 – 206206Missing in isoform Delta.
VSP_005155
Alternative sequence1 – 77MRRAVCF → MQSISKQ in isoform 4.
VSP_046352
Alternative sequence8 – 119112Missing in isoform 4.
VSP_046353
Alternative sequence207 – 2093SPE → MNQ in isoform Delta.
VSP_005158
Natural variant2491Y → H.
Corresponds to variant rs35987017 [ dbSNP | Ensembl ].
VAR_057140
Natural variant3141K → R. Ref.1 Ref.2 Ref.3 Ref.4 Ref.5 Ref.7
Corresponds to variant rs3803036 [ dbSNP | Ensembl ].
VAR_014283
Natural variant3861V → I.
Corresponds to variant rs35387004 [ dbSNP | Ensembl ].
VAR_057141
Natural variant4391V → I.
Corresponds to variant rs35390084 [ dbSNP | Ensembl ].
VAR_057142

Experimental info

Sequence conflict4071P → S in BAH12227. Ref.5

Secondary structure

................................................ 657
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform Alpha [UniParc].

Last modified March 6, 2007. Version 2.
Checksum: 42CD98F37AC5B638

FASTA65773,834
        10         20         30         40         50         60 
MRRAVCFPAL CLLLNLHAAG CFSGNNDHFL AINQKKSGKP VFIYKHSQDI EKSLDIAPQK 

        70         80         90        100        110        120 
IYRHSYHSSS EAQVSKRHQI VNSAFPRPAY DPSLNLLAMD GQDLEVENLP IPAANVIVVT 

       130        140        150        160        170        180 
LQMDVNKLNI TLLRIFRQGV AAALGLLPQQ VHINRLIGKK NSIELFVSPI NRKTGISDAL 

       190        200        210        220        230        240 
PSEEVLRSLN INVLHQSLSQ FGITEVSPEK NVLQGQHEAD KIWSKEGFYA VVIFLSIFVI 

       250        260        270        280        290        300 
IVTCLMILYR LKERFQLSLR QDKEKNQEIH LSPITLQPAL SEAKTVHSMV QPEQAPKVLN 

       310        320        330        340        350        360 
VVVDPQGRGA PEIKATTATS VCPSPFKMKP IGLQERRGSN VSLTLDMSSL GNIEPFVSIP 

       370        380        390        400        410        420 
TPREKVAMEY LQSASRILTR SQLRDVVASS HLLQSEFMEI PMNFVDPKEI DIPRHGTKNR 

       430        440        450        460        470        480 
YKTILPNPLS RVCLRPKNVT DSLSTYINAN YIRGYSGKEK AFIATQGPMI NTVDDFWQMV 

       490        500        510        520        530        540 
WQEDSPVIVM ITKLKEKNEK CVLYWPEKRG IYGKVEVLVI SVNECDNYTI RNLVLKQGSH 

       550        560        570        580        590        600 
TQHVKHYWYT SWPDHKTPDS AQPLLQLMLD VEEDRLASQG RGPVVVHCSA GIGRTGCFIA 

       610        620        630        640        650 
TSIGCQQLKE EGVVDALSIV CQLRMDRGGM VQTSEQYEFV HHALCLYESR LSAETVQ 

« Hide

Isoform Gamma [UniParc].

Checksum: 92D2900B943CBDBB
Show »

FASTA41246,581
Isoform Delta [UniParc].

Checksum: 7AC02DFE48E42761
Show »

FASTA45151,046
Isoform 4 [UniParc].

Checksum: 67867697541BC393
Show »

FASTA54561,415

References

« Hide 'large scale' references
[1]"Cloning and expression of PCPTP1 encoding protein tyrosine phosphatase."
Shiozuka K., Watanabe Y., Ikeda T., Hashimoto S., Kawashima H.
Gene 162:279-284(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT ARG-314.
Tissue: Brain.
[2]"Protein tyrosine phosphatase (PC12, Br7,Sl) family: expression characterization in the adult human and mouse."
Augustine K.A., Silbiger S.M., Bucay N., Ulias L., Boynton A., Trebasky L.D., Medlock E.S.
Anat. Rec. 258:221-234(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA; GAMMA AND DELTA), TISSUE SPECIFICITY, VARIANT ARG-314.
Tissue: Brain and Colon.
[3]"Type 2 diabetes locus on 12q15: further mapping and mutation screening of two candidate genes."
Bektas A., Hughes J.N., Warram J.H., Krolewski A.S., Doria A.
Diabetes 50:204-208(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT ARG-314.
[4]"Cloning and characterization of novel PTP (NC-PTPCOM) from neuronal cells."
Knyazev P., Cheburkin Y., Knyazev Y., Ullrich A.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), VARIANT ARG-314.
Tissue: Neuroblastoma.
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS ALPHA AND 4), VARIANT ARG-314.
Tissue: Amygdala and Substantia nigra.
[6]"The finished DNA sequence of human chromosome 12."
Scherer S.E., Muzny D.M., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J., Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R. expand/collapse author list , Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Montgomery K.T., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Lovering R.C., Wheeler D.A., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clerc-Blankenburg K.P., Davis C., Delgado O., Dinh H.H., Draper H., Gonzalez-Garay M.L., Havlak P., Jackson L.R., Jacob L.S., Kelly S.H., Li L., Li Z., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Pasternak S., Perez L.M., Plopper F.J.H., Santibanez J., Shen H., Tabor P.E., Verduzco D., Waldron L., Wang Q., Williams G.A., Zhang J., Zhou J., Allen C.C., Amin A.G., Anyalebechi V., Bailey M., Barbaria J.A., Bimage K.E., Bryant N.P., Burch P.E., Burkett C.E., Burrell K.L., Calderon E., Cardenas V., Carter K., Casias K., Cavazos I., Cavazos S.R., Ceasar H., Chacko J., Chan S.N., Chavez D., Christopoulos C., Chu J., Cockrell R., Cox C.D., Dang M., Dathorne S.R., David R., Davis C.M., Davy-Carroll L., Deshazo D.R., Donlin J.E., D'Souza L., Eaves K.A., Egan A., Emery-Cohen A.J., Escotto M., Flagg N., Forbes L.D., Gabisi A.M., Garza M., Hamilton C., Henderson N., Hernandez O., Hines S., Hogues M.E., Huang M., Idlebird D.G., Johnson R., Jolivet A., Jones S., Kagan R., King L.M., Leal B., Lebow H., Lee S., LeVan J.M., Lewis L.C., London P., Lorensuhewa L.M., Loulseged H., Lovett D.A., Lucier A., Lucier R.L., Ma J., Madu R.C., Mapua P., Martindale A.D., Martinez E., Massey E., Mawhiney S., Meador M.G., Mendez S., Mercado C., Mercado I.C., Merritt C.E., Miner Z.L., Minja E., Mitchell T., Mohabbat F., Mohabbat K., Montgomery B., Moore N., Morris S., Munidasa M., Ngo R.N., Nguyen N.B., Nickerson E., Nwaokelemeh O.O., Nwokenkwo S., Obregon M., Oguh M., Oragunye N., Oviedo R.J., Parish B.J., Parker D.N., Parrish J., Parks K.L., Paul H.A., Payton B.A., Perez A., Perrin W., Pickens A., Primus E.L., Pu L.-L., Puazo M., Quiles M.M., Quiroz J.B., Rabata D., Reeves K., Ruiz S.J., Shao H., Sisson I., Sonaike T., Sorelle R.P., Sutton A.E., Svatek A.F., Svetz L.A., Tamerisa K.S., Taylor T.R., Teague B., Thomas N., Thorn R.D., Trejos Z.Y., Trevino B.K., Ukegbu O.N., Urban J.B., Vasquez L.I., Vera V.A., Villasana D.M., Wang L., Ward-Moore S., Warren J.T., Wei X., White F., Williamson A.L., Wleczyk R., Wooden H.S., Wooden S.H., Yen J., Yoon L., Yoon V., Zorrilla S.E., Nelson D., Kucherlapati R., Weinstock G., Gibbs R.A.
Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"Molecular cloning and characterization of human epithelial cells specific protein tyrosine phosphatase (EC-PTP)."
Knyazev P.G., Ullrich A.
Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 289-657 (ISOFORM ALPHA), VARIANT ARG-314.
Tissue: Mammary gland.
[8]"Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases."
Eswaran J., von Kries J.P., Marsden B., Longman E., Debreczeni J.E., Ugochukwu E., Turnbull A., Lee W.H., Knapp S., Barr A.J.
Biochem. J. 395:483-491(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 375-655.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
D64053 mRNA. Translation: BAA10930.1.
U42361 mRNA. Translation: AAD09447.1.
U77917 mRNA. Translation: AAB54007.1.
U77916 mRNA. Translation: AAB54006.1.
AF263029 expand/collapse EMBL AC list , AF263016, AF263017, AF263018, AF263019, AF263020, AF263021, AF263022, AF263023, AF263024, AF263025, AF263026, AF263027, AF263028 Genomic DNA. Translation: AAG47642.1.
Z79693 mRNA. Translation: CAB01957.1. Frameshift.
AK295951 mRNA. Translation: BAH12227.1.
AK312376 mRNA. Translation: BAG35294.1.
AC083809 Genomic DNA. No translation available.
AC084877 Genomic DNA. No translation available.
AC090676 Genomic DNA. No translation available.
AC140066 Genomic DNA. No translation available.
X82635 mRNA. Translation: CAA57957.1. Frameshift.
RefSeqNP_001193944.1. NM_001207015.1.
NP_001193945.1. NM_001207016.1.
NP_002840.2. NM_002849.3.
NP_570897.2. NM_130846.2.
UniGeneHs.506076.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2A8BX-ray2.30A375-655[»]
ProteinModelPortalQ15256.
SMRQ15256. Positions 375-655.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111765. 3 interactions.
DIPDIP-42066N.
IntActQ15256. 4 interactions.
MINTMINT-1350037.
STRING9606.ENSP00000283228.

PTM databases

PhosphoSiteQ15256.

Polymorphism databases

DMDM134039192.

Proteomic databases

PaxDbQ15256.
PRIDEQ15256.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000283228; ENSP00000283228; ENSG00000153233. [Q15256-1]
ENST00000342084; ENSP00000339605; ENSG00000153233. [Q15256-5]
ENST00000378778; ENSP00000368054; ENSG00000153233. [Q15256-4]
ENST00000440835; ENSP00000391750; ENSG00000153233. [Q15256-3]
ENST00000549308; ENSP00000446943; ENSG00000153233. [Q15256-3]
GeneID5801.
KEGGhsa:5801.
UCSCuc001swh.2. human. [Q15256-1]
uc009zrs.3. human. [Q15256-4]

Organism-specific databases

CTD5801.
GeneCardsGC12M071031.
HGNCHGNC:9680. PTPRR.
HPACAB011461.
HPA011851.
MIM602853. gene.
neXtProtNX_Q15256.
PharmGKBPA34025.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5599.
HOGENOMHOG000294188.
HOVERGENHBG001594.
KOK04458.
OMAPIGLQER.
OrthoDBEOG7288QX.
PhylomeDBQ15256.
TreeFamTF331016.

Enzyme and pathway databases

BRENDA3.1.3.48. 2681.

Gene expression databases

ArrayExpressQ15256.
BgeeQ15256.
CleanExHS_PTPRQ.
HS_PTPRR.
GenevestigatorQ15256.

Family and domain databases

InterProIPR000387. Tyr/Dual-sp_Pase.
IPR016130. Tyr_Pase_AS.
IPR008356. Tyr_Pase_KIM-con.
IPR000242. Tyr_Pase_rcpt/non-rcpt.
IPR016334. Tyr_Pase_rcpt_R/non-rcpt_5.
[Graphical view]
PfamPF00102. Y_phosphatase. 1 hit.
[Graphical view]
PIRSFPIRSF001997. PTPRR. 1 hit.
PRINTSPR01778. KIMPTPASE.
PR00700. PRTYPHPHTASE.
SMARTSM00194. PTPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. 1 hit.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50055. TYR_PHOSPHATASE_PTP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceQ15256.
GeneWikiPTPRR.
GenomeRNAi5801.
NextBio22606.
PROQ15256.
SOURCESearch...

Entry information

Entry namePTPRR_HUMAN
AccessionPrimary (citable) accession number: Q15256
Secondary accession number(s): B2R5Z7 expand/collapse secondary AC list , B7Z3J1, F5GXR7, O00342, Q92682, Q9UE65
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: March 6, 2007
Last modified: April 16, 2014
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM