ID   PSG5_HUMAN              Reviewed;         335 AA.
AC   Q15238; Q15239; Q96QJ1; Q9UQ75;
DT   30-MAY-2000, integrated into UniProtKB/Swiss-Prot.
DT   02-NOV-2010, sequence version 3.
DT   27-MAR-2024, entry version 190.
DE   RecName: Full=Pregnancy-specific beta-1-glycoprotein 5;
DE            Short=PS-beta-G-5;
DE            Short=PSBG-5;
DE            Short=Pregnancy-specific glycoprotein 5;
DE   AltName: Full=Fetal liver non-specific cross-reactive antigen 3;
DE            Short=FL-NCA-3;
DE   Flags: Precursor;
GN   Name=PSG5;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND VARIANTS VAL-18 AND HIS-227.
RC   TISSUE=Placenta;
RX   PubMed=2789512; DOI=10.1016/0006-291x(89)92324-3;
RA   Oikawa S., Inuzuka C., Kuroki M., Matsuoka Y., Kosaki G., Nakazato H.;
RT   "A pregnancy-specific beta 1-glycoprotein, a CEA gene family member,
RT   expressed in a human promyelocytic leukemia cell line, HL-60: structures of
RT   protein, mRNA and gene.";
RL   Biochem. Biophys. Res. Commun. 163:1021-1031(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND VARIANTS VAL-18; LYS-154 AND HIS-227.
RC   TISSUE=Placenta;
RX   PubMed=1922019; DOI=10.1007/bf00230182;
RA   Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.;
RT   "Characterization of new members of the pregnancy-specific beta 1-
RT   glycoprotein family.";
RL   Mol. Cell. Biochem. 106:161-170(1991).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANTS VAL-18; LYS-154 AND
RP   HIS-227.
RX   PubMed=2735907; DOI=10.1016/0006-291x(89)92631-4;
RA   Khan W.N., Hammarstroem S.;
RT   "Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-
RT   beta-G/FL-NCA glycoprotein with a novel domain arrangement.";
RL   Biochem. Biophys. Res. Commun. 161:525-535(1989).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS VAL-18 AND HIS-227.
RC   TISSUE=Placenta;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
RA   Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.;
RT   "Characterization of upstream promotor region, exon 1 and exon 2 of the PSG
RT   gene family.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=21406692; DOI=10.1126/scisignal.2001570;
RA   Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T.,
RA   Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.;
RT   "System-wide temporal characterization of the proteome and phosphoproteome
RT   of human embryonic stem cell differentiation.";
RL   Sci. Signal. 4:RS3-RS3(2011).
CC   -!- INTERACTION:
CC       Q15238; P35590: TIE1; NbExp=3; IntAct=EBI-4314891, EBI-2256865;
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Synthesized by syncytiotrophoblast of the placenta.
CC   -!- DEVELOPMENTAL STAGE: PSBG are produced in high quantity during
CC       pregnancy.
CC   -!- SIMILARITY: Belongs to the immunoglobulin superfamily. CEA family.
CC       {ECO:0000305}.
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DR   EMBL; M73713; AAA60205.1; -; mRNA.
DR   EMBL; M25384; AAA36514.1; -; mRNA.
DR   EMBL; AC005392; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC012607; AAH12607.1; -; mRNA.
DR   EMBL; AH007626; AAD28500.1; -; Genomic_DNA.
DR   CCDS; CCDS12617.1; -.
DR   PIR; A33514; A33514.
DR   PIR; B33251; B33251.
DR   PIR; C54312; C54312.
DR   RefSeq; NP_001123486.1; NM_001130014.1.
DR   RefSeq; NP_002772.3; NM_002781.3.
DR   RefSeq; XP_016882492.1; XM_017027003.1.
DR   AlphaFoldDB; Q15238; -.
DR   SMR; Q15238; -.
DR   BioGRID; 111648; 4.
DR   IntAct; Q15238; 3.
DR   MINT; Q15238; -.
DR   STRING; 9606.ENSP00000382334; -.
DR   DrugBank; DB00523; Alitretinoin.
DR   GlyCosmos; Q15238; 4 sites, No reported glycans.
DR   GlyGen; Q15238; 5 sites, 1 O-linked glycan (1 site).
DR   iPTMnet; Q15238; -.
DR   PhosphoSitePlus; Q15238; -.
DR   BioMuta; PSG5; -.
DR   DMDM; 311033414; -.
DR   jPOST; Q15238; -.
DR   MassIVE; Q15238; -.
DR   PaxDb; 9606-ENSP00000382334; -.
DR   PeptideAtlas; Q15238; -.
DR   ProteomicsDB; 60495; -.
DR   Antibodypedia; 21553; 57 antibodies from 16 providers.
DR   DNASU; 5673; -.
DR   Ensembl; ENST00000342951.11; ENSP00000344413.6; ENSG00000204941.14.
DR   Ensembl; ENST00000366175.7; ENSP00000382334.2; ENSG00000204941.14.
DR   Ensembl; ENST00000407356.5; ENSP00000386008.1; ENSG00000204941.14.
DR   GeneID; 5673; -.
DR   KEGG; hsa:5673; -.
DR   MANE-Select; ENST00000342951.11; ENSP00000344413.6; NM_002781.4; NP_002772.3.
DR   UCSC; uc002ovu.4; human.
DR   AGR; HGNC:9522; -.
DR   CTD; 5673; -.
DR   DisGeNET; 5673; -.
DR   GeneCards; PSG5; -.
DR   HGNC; HGNC:9522; PSG5.
DR   HPA; ENSG00000204941; Tissue enriched (placenta).
DR   MIM; 176394; gene.
DR   neXtProt; NX_Q15238; -.
DR   OpenTargets; ENSG00000204941; -.
DR   PharmGKB; PA33867; -.
DR   VEuPathDB; HostDB:ENSG00000204941; -.
DR   eggNOG; ENOG502RWXZ; Eukaryota.
DR   GeneTree; ENSGT01100000263479; -.
DR   InParanoid; Q15238; -.
DR   OMA; XRESSAN; -.
DR   OrthoDB; 3033616at2759; -.
DR   PhylomeDB; Q15238; -.
DR   TreeFam; TF336859; -.
DR   PathwayCommons; Q15238; -.
DR   Reactome; R-HSA-202733; Cell surface interactions at the vascular wall.
DR   SignaLink; Q15238; -.
DR   BioGRID-ORCS; 5673; 34 hits in 1098 CRISPR screens.
DR   ChiTaRS; PSG5; human.
DR   GeneWiki; PSG5; -.
DR   GenomeRNAi; 5673; -.
DR   Pharos; Q15238; Tbio.
DR   PRO; PR:Q15238; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   RNAct; Q15238; Protein.
DR   Bgee; ENSG00000204941; Expressed in placenta and 126 other cell types or tissues.
DR   ExpressionAtlas; Q15238; baseline and differential.
DR   GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007565; P:female pregnancy; TAS:ProtInc.
DR   GO; GO:0007157; P:heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; IBA:GO_Central.
DR   CDD; cd20948; IgC2_CEACAM5-like; 1.
DR   CDD; cd05740; IgI_hCEACAM_2_4_6_like; 1.
DR   CDD; cd05774; IgV_CEACAM_D1; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR   InterPro; IPR007110; Ig-like_dom.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR003599; Ig_sub.
DR   InterPro; IPR003598; Ig_sub2.
DR   InterPro; IPR013106; Ig_V-set.
DR   PANTHER; PTHR44427; CARCINOEMBRYONIC ANTIGEN-RELATED CELL ADHESION MOLECULE 19; 1.
DR   PANTHER; PTHR44427:SF24; IG-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF13895; Ig_2; 1.
DR   Pfam; PF13927; Ig_3; 1.
DR   Pfam; PF07686; V-set; 1.
DR   SMART; SM00409; IG; 3.
DR   SMART; SM00408; IGc2; 2.
DR   SUPFAM; SSF48726; Immunoglobulin; 3.
DR   PROSITE; PS50835; IG_LIKE; 2.
DR   Genevisible; Q15238; HS.
PE   1: Evidence at protein level;
KW   Disulfide bond; Glycoprotein; Immunoglobulin domain; Reference proteome;
KW   Repeat; Secreted; Signal.
FT   SIGNAL          1..34
FT                   /evidence="ECO:0000255"
FT   CHAIN           35..335
FT                   /note="Pregnancy-specific beta-1-glycoprotein 5"
FT                   /id="PRO_0000014912"
FT   DOMAIN          35..144
FT                   /note="Ig-like V-type"
FT   DOMAIN          147..234
FT                   /note="Ig-like C2-type 1"
FT   DOMAIN          239..317
FT                   /note="Ig-like C2-type 2"
FT   MOTIF           127..129
FT                   /note="Cell attachment site"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        104
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        111
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        175
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        210
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        169..217
FT                   /evidence="ECO:0000305"
FT   DISULFID        261..301
FT                   /evidence="ECO:0000305"
FT   VARIANT         18
FT                   /note="L -> V (in dbSNP:rs8107936)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:1922019, ECO:0000269|PubMed:2735907,
FT                   ECO:0000269|PubMed:2789512"
FT                   /id="VAR_060260"
FT   VARIANT         154
FT                   /note="N -> K (in dbSNP:rs1058259)"
FT                   /evidence="ECO:0000269|PubMed:1922019,
FT                   ECO:0000269|PubMed:2735907"
FT                   /id="VAR_016041"
FT   VARIANT         168
FT                   /note="T -> I (in dbSNP:rs5013158)"
FT                   /id="VAR_060261"
FT   VARIANT         227
FT                   /note="R -> H (in dbSNP:rs1058285)"
FT                   /evidence="ECO:0000269|PubMed:15489334,
FT                   ECO:0000269|PubMed:1922019, ECO:0000269|PubMed:2735907,
FT                   ECO:0000269|PubMed:2789512"
FT                   /id="VAR_060262"
FT   CONFLICT        15
FT                   /note="W -> C (in Ref. 2; AAA60205)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        20
FT                   /note="L -> V (in Ref. 3; AAA36514)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        195
FT                   /note="R -> Q (in Ref. 1; no nucleotide entry and 5;
FT                   AAH12607)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        232
FT                   /note="T -> S (in Ref. 2; AAA60205 and 3; AAA36514)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        240
FT                   /note="D -> Y (in Ref. 3; AAA36514)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        288
FT                   /note="I -> M (in Ref. 3; AAA36514)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   335 AA;  37713 MW;  E14EA6E9DAA88296 CRC64;
     MGPLSAPPCT QHITWKGLLL TASLLNFWNL PITAQVTIEA LPPKVSEGKD VLLLVHNLPQ
     NLAGYIWYKG QLMDLYHYIT SYVVDGQINI YGPAYTGRET VYSNASLLIQ NVTREDAGSY
     TLHIIKRGDR TRGVTGYFTF NLYLKLPKPY ITINNSKPRE NKDVLAFTCE PKSENYTYIW
     WLNGQSLPVS PRVKRPIENR ILILPSVTRN ETGPYECEIR DRDGGMRSDP VTLNVLYGPD
     LPSIYPSFTY YRSGENLYLS CFAESNPPAE YFWTINGKFQ QSGQKLSIPQ ITTKHRGLYT
     CSVRNSATGK ESSKSMTVEV SAPSGIGRLP LLNPI
//