Q15238 (PSG5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Pregnancy-specific beta-1-glycoprotein 5
Short name=PS-beta-G-5
Short name=PSBG-5
Short name=Pregnancy-specific glycoprotein 5

Alternative name(s):
Fetal liver non-specific cross-reactive antigen 3
Short name=FL-NCA-3

Gene names

Name:

PSG5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	335 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subcellular location	Secreted Potential.
Tissue specificity	Synthesized by syncytiotrophoblast of the placenta.
Developmental stage	PSBG are produced in high quantity during pregnancy.
Sequence similarities	Belongs to the immunoglobulin superfamily. CEA family. Contains 2 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
Cellular component	Secreted
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	female pregnancy Traceable author statement PubMed 1690992. Source: ProtInc
Cellular_component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
TIE1	P35590	3	EBI-4314891,EBI-2256865

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 34	34	Potential
	Chain	35 – 335	301	Pregnancy-specific beta-1-glycoprotein 5		PRO_0000014912
Regions
	Domain	35 – 144	110	Ig-like V-type
	Domain	147 – 234	88	Ig-like C2-type 1
	Domain	239 – 317	79	Ig-like C2-type 2
	Motif	127 – 129	3	Cell attachment site Potential
Amino acid modifications
	Glycosylation	104	1	N-linked (GlcNAc...) Potential
	Glycosylation	111	1	N-linked (GlcNAc...) Potential
	Glycosylation	175	1	N-linked (GlcNAc...) Potential
	Glycosylation	210	1	N-linked (GlcNAc...) Potential
	Disulfide bond	169 ↔ 217		Probable
	Disulfide bond	261 ↔ 301		Probable
Natural variations
	Natural variant	18	1	L → V. Ref.1 Ref.2 Ref.3 Ref.5 Corresponds to variant rs8107936 [ dbSNP | Ensembl ].		VAR_060260
	Natural variant	154	1	N → K. Ref.2 Ref.3 Corresponds to variant rs1058259 [ dbSNP | Ensembl ].		VAR_016041
	Natural variant	168	1	T → I. Corresponds to variant rs5013158 [ dbSNP | Ensembl ].		VAR_060261
	Natural variant	227	1	R → H. Ref.1 Ref.2 Ref.3 Ref.5 Corresponds to variant rs1058285 [ dbSNP | Ensembl ].		VAR_060262
Experimental info
	Sequence conflict	15	1	W → C in AAA60205. Ref.2
	Sequence conflict	20	1	L → V in AAA36514. Ref.3
	Sequence conflict	195	1	R → Q no nucleotide entry Ref.1
	Sequence conflict	195	1	R → Q in AAH12607. Ref.5
	Sequence conflict	232	1	T → S in AAA60205. Ref.2
	Sequence conflict	232	1	T → S in AAA36514. Ref.3
	Sequence conflict	240	1	D → Y in AAA36514. Ref.3
	Sequence conflict	288	1	I → M in AAA36514. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Q15238 [UniParc]. Last modified November 2, 2010. Version 3. Checksum: E14EA6E9DAA88296	FASTA	335	37,713
	10 20 30 40 50 60 MGPLSAPPCT QHITWKGLLL TASLLNFWNL PITAQVTIEA LPPKVSEGKD VLLLVHNLPQ 70 80 90 100 110 120 NLAGYIWYKG QLMDLYHYIT SYVVDGQINI YGPAYTGRET VYSNASLLIQ NVTREDAGSY 130 140 150 160 170 180 TLHIIKRGDR TRGVTGYFTF NLYLKLPKPY ITINNSKPRE NKDVLAFTCE PKSENYTYIW 190 200 210 220 230 240 WLNGQSLPVS PRVKRPIENR ILILPSVTRN ETGPYECEIR DRDGGMRSDP VTLNVLYGPD 250 260 270 280 290 300 LPSIYPSFTY YRSGENLYLS CFAESNPPAE YFWTINGKFQ QSGQKLSIPQ ITTKHRGLYT 310 320 330 CSVRNSATGK ESSKSMTVEV SAPSGIGRLP LLNPI

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene." Oikawa S., Inuzuka C., Kuroki M., Matsuoka Y., Kosaki G., Nakazato H. Biochem. Biophys. Res. Commun. 163:1021-1031(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS VAL-18 AND HIS-227. Tissue: Placenta.
[2]	"Characterization of new members of the pregnancy-specific beta 1-glycoprotein family." Chan W.Y., Zheng Q.X., McMahon J., Tease L.A. Mol. Cell. Biochem. 106:161-170(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-18; LYS-154 AND HIS-227. Tissue: Placenta.
[3]	"Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement." Khan W.N., Hammarstroem S. Biochem. Biophys. Res. Commun. 161:525-535(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-18; LYS-154 AND HIS-227.
[4]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M. Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-18 AND HIS-227. Tissue: Placenta.
[6]	"Characterization of upstream promotor region, exon 1 and exon 2 of the PSG gene family." Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S. Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
[7]	"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation." Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B. Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	M73713 mRNA. Translation: AAA60205.1. M25384 mRNA. Translation: AAA36514.1. AC005392 Genomic DNA. No translation available. BC012607 mRNA. Translation: AAH12607.1. AH007626 Genomic DNA. Translation: AAD28500.1.
IPI	IPI00300046.
PIR	A33514. B33251. C54312.
RefSeq	NP_001123486.1. NM_001130014.1. NP_002772.3. NM_002781.3.
UniGene	Hs.654415.
3D structure databases
ProteinModelPortal	Q15238.
SMR	Q15238. Positions 34-318.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q15238. 1 interaction.
MINT	MINT-1196995.
STRING	9606.ENSP00000344413.
PTM databases
PhosphoSite	Q15238.
Polymorphism databases
DMDM	311033414.
Proteomic databases
PaxDb	Q15238.
PRIDE	Q15238.
Protocols and materials databases
DNASU	5673.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000342951; ENSP00000344413; ENSG00000204941. ENST00000366175; ENSP00000382334; ENSG00000204941. ENST00000407356; ENSP00000386008; ENSG00000204941.
GeneID	5673.
KEGG	hsa:5673.
UCSC	uc002ovu.3. human.
Organism-specific databases
CTD	5673.
GeneCards	GC19M043670.
H-InvDB	HIX0096869.
HGNC	HGNC:9522. PSG5.
HPA	HPA046327.
MIM	176394. gene.
neXtProt	NX_Q15238.
PharmGKB	PA33867.
GenAtlas	Search...
Phylogenomic databases
eggNOG	KOG4475.
HOGENOM	HOG000233417.
HOVERGEN	HBG007922.
KO	K06500.
OMA	QITTKHR.
OrthoDB	EOG41ZFBV.
Gene expression databases
ArrayExpress	Q15238.
Bgee	Q15238.
CleanEx	HS_PSG5.
Genevestigator	Q15238.
GermOnline	ENSG00000204941. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 3 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. IPR003598. Ig_sub2. IPR013106. Ig_V-set. [Graphical view]
Pfam	PF07686. V-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 2 hits. SM00408. IGc2. 1 hit. [Graphical view]
PROSITE	PS50835. IG_LIKE. 2 hits. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	5673.
NextBio	22034.
SOURCE	Search...

Entry information

Entry name

PSG5_HUMAN

Accession

Primary (citable) accession number: Q15238
Secondary accession number(s): Q15239, Q96QJ1, Q9UQ75

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	November 2, 2010
Last modified:	May 1, 2013
This is version 124 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.