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Q15238

- PSG5_HUMAN

UniProt

Q15238 - PSG5_HUMAN

Protein

Pregnancy-specific beta-1-glycoprotein 5

Gene

PSG5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. female pregnancy Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pregnancy-specific beta-1-glycoprotein 5
    Short name:
    PS-beta-G-5
    Short name:
    PSBG-5
    Short name:
    Pregnancy-specific glycoprotein 5
    Alternative name(s):
    Fetal liver non-specific cross-reactive antigen 3
    Short name:
    FL-NCA-3
    Gene namesi
    Name:PSG5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:9522. PSG5.

    Subcellular locationi

    Secreted Curated

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33867.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3434Sequence AnalysisAdd
    BLAST
    Chaini35 – 335301Pregnancy-specific beta-1-glycoprotein 5PRO_0000014912Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi169 ↔ 217Curated
    Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi261 ↔ 301Curated

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ15238.
    PRIDEiQ15238.

    PTM databases

    PhosphoSiteiQ15238.

    Expressioni

    Tissue specificityi

    Synthesized by syncytiotrophoblast of the placenta.

    Developmental stagei

    PSBG are produced in high quantity during pregnancy.

    Gene expression databases

    ArrayExpressiQ15238.
    BgeeiQ15238.
    CleanExiHS_PSG5.
    GenevestigatoriQ15238.

    Organism-specific databases

    HPAiHPA046327.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    TIE1P355903EBI-4314891,EBI-2256865

    Protein-protein interaction databases

    BioGridi111648. 2 interactions.
    IntActiQ15238. 2 interactions.
    MINTiMINT-1196995.
    STRINGi9606.ENSP00000344413.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15238.
    SMRiQ15238. Positions 34-330.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini35 – 144110Ig-like V-typeAdd
    BLAST
    Domaini147 – 23488Ig-like C2-type 1Add
    BLAST
    Domaini239 – 31779Ig-like C2-type 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi127 – 1293Cell attachment siteSequence Analysis

    Sequence similaritiesi

    Belongs to the immunoglobulin superfamily. CEA family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiKOG4475.
    HOGENOMiHOG000233417.
    HOVERGENiHBG007922.
    KOiK06500.
    OrthoDBiEOG74BJS7.
    PhylomeDBiQ15238.
    TreeFamiTF336859.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q15238-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGPLSAPPCT QHITWKGLLL TASLLNFWNL PITAQVTIEA LPPKVSEGKD    50
    VLLLVHNLPQ NLAGYIWYKG QLMDLYHYIT SYVVDGQINI YGPAYTGRET 100
    VYSNASLLIQ NVTREDAGSY TLHIIKRGDR TRGVTGYFTF NLYLKLPKPY 150
    ITINNSKPRE NKDVLAFTCE PKSENYTYIW WLNGQSLPVS PRVKRPIENR 200
    ILILPSVTRN ETGPYECEIR DRDGGMRSDP VTLNVLYGPD LPSIYPSFTY 250
    YRSGENLYLS CFAESNPPAE YFWTINGKFQ QSGQKLSIPQ ITTKHRGLYT 300
    CSVRNSATGK ESSKSMTVEV SAPSGIGRLP LLNPI 335
    Length:335
    Mass (Da):37,713
    Last modified:November 2, 2010 - v3
    Checksum:iE14EA6E9DAA88296
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti15 – 151W → C in AAA60205. (PubMed:1922019)Curated
    Sequence conflicti20 – 201L → V in AAA36514. (PubMed:2735907)Curated
    Sequence conflicti195 – 1951R → Q no nucleotide entry (PubMed:2789512)Curated
    Sequence conflicti195 – 1951R → Q in AAH12607. (PubMed:15489334)Curated
    Sequence conflicti232 – 2321T → S in AAA60205. (PubMed:1922019)Curated
    Sequence conflicti232 – 2321T → S in AAA36514. (PubMed:2735907)Curated
    Sequence conflicti240 – 2401D → Y in AAA36514. (PubMed:2735907)Curated
    Sequence conflicti288 – 2881I → M in AAA36514. (PubMed:2735907)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti18 – 181L → V.4 Publications
    Corresponds to variant rs8107936 [ dbSNP | Ensembl ].
    VAR_060260
    Natural varianti154 – 1541N → K.2 Publications
    Corresponds to variant rs1058259 [ dbSNP | Ensembl ].
    VAR_016041
    Natural varianti168 – 1681T → I.
    Corresponds to variant rs5013158 [ dbSNP | Ensembl ].
    VAR_060261
    Natural varianti227 – 2271R → H.4 Publications
    Corresponds to variant rs1058285 [ dbSNP | Ensembl ].
    VAR_060262

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73713 mRNA. Translation: AAA60205.1.
    M25384 mRNA. Translation: AAA36514.1.
    AC005392 Genomic DNA. No translation available.
    BC012607 mRNA. Translation: AAH12607.1.
    AH007626 Genomic DNA. Translation: AAD28500.1.
    CCDSiCCDS12617.1.
    PIRiA33514.
    B33251.
    C54312.
    RefSeqiNP_001123486.1. NM_001130014.1.
    NP_002772.3. NM_002781.3.
    UniGeneiHs.654415.

    Genome annotation databases

    EnsembliENST00000342951; ENSP00000344413; ENSG00000204941.
    ENST00000366175; ENSP00000382334; ENSG00000204941.
    ENST00000407356; ENSP00000386008; ENSG00000204941.
    GeneIDi5673.
    KEGGihsa:5673.
    UCSCiuc002ovu.3. human.

    Polymorphism databases

    DMDMi311033414.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73713 mRNA. Translation: AAA60205.1 .
    M25384 mRNA. Translation: AAA36514.1 .
    AC005392 Genomic DNA. No translation available.
    BC012607 mRNA. Translation: AAH12607.1 .
    AH007626 Genomic DNA. Translation: AAD28500.1 .
    CCDSi CCDS12617.1.
    PIRi A33514.
    B33251.
    C54312.
    RefSeqi NP_001123486.1. NM_001130014.1.
    NP_002772.3. NM_002781.3.
    UniGenei Hs.654415.

    3D structure databases

    ProteinModelPortali Q15238.
    SMRi Q15238. Positions 34-330.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111648. 2 interactions.
    IntActi Q15238. 2 interactions.
    MINTi MINT-1196995.
    STRINGi 9606.ENSP00000344413.

    PTM databases

    PhosphoSitei Q15238.

    Polymorphism databases

    DMDMi 311033414.

    Proteomic databases

    PaxDbi Q15238.
    PRIDEi Q15238.

    Protocols and materials databases

    DNASUi 5673.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000342951 ; ENSP00000344413 ; ENSG00000204941 .
    ENST00000366175 ; ENSP00000382334 ; ENSG00000204941 .
    ENST00000407356 ; ENSP00000386008 ; ENSG00000204941 .
    GeneIDi 5673.
    KEGGi hsa:5673.
    UCSCi uc002ovu.3. human.

    Organism-specific databases

    CTDi 5673.
    GeneCardsi GC19M043670.
    H-InvDB HIX0096869.
    HGNCi HGNC:9522. PSG5.
    HPAi HPA046327.
    MIMi 176394. gene.
    neXtProti NX_Q15238.
    PharmGKBi PA33867.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi KOG4475.
    HOGENOMi HOG000233417.
    HOVERGENi HBG007922.
    KOi K06500.
    OrthoDBi EOG74BJS7.
    PhylomeDBi Q15238.
    TreeFami TF336859.

    Miscellaneous databases

    GeneWikii PSG5.
    GenomeRNAii 5673.
    NextBioi 22034.
    PROi Q15238.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15238.
    Bgeei Q15238.
    CleanExi HS_PSG5.
    Genevestigatori Q15238.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    SM00408. IGc2. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene."
      Oikawa S., Inuzuka C., Kuroki M., Matsuoka Y., Kosaki G., Nakazato H.
      Biochem. Biophys. Res. Commun. 163:1021-1031(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS VAL-18 AND HIS-227.
      Tissue: Placenta.
    2. "Characterization of new members of the pregnancy-specific beta 1-glycoprotein family."
      Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.
      Mol. Cell. Biochem. 106:161-170(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-18; LYS-154 AND HIS-227.
      Tissue: Placenta.
    3. "Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement."
      Khan W.N., Hammarstroem S.
      Biochem. Biophys. Res. Commun. 161:525-535(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-18; LYS-154 AND HIS-227.
    4. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-18 AND HIS-227.
      Tissue: Placenta.
    6. "Characterization of upstream promotor region, exon 1 and exon 2 of the PSG gene family."
      Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
      Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
    7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiPSG5_HUMAN
    AccessioniPrimary (citable) accession number: Q15238
    Secondary accession number(s): Q15239, Q96QJ1, Q9UQ75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3