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Protein

Pregnancy-specific beta-1-glycoprotein 5

Gene

PSG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • female pregnancy Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170848-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 5
Short name:
PS-beta-G-5
Short name:
PSBG-5
Short name:
Pregnancy-specific glycoprotein 5
Alternative name(s):
Fetal liver non-specific cross-reactive antigen 3
Short name:
FL-NCA-3
Gene namesi
Name:PSG5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9522. PSG5.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5673.
OpenTargetsiENSG00000204941.
PharmGKBiPA33867.

Polymorphism and mutation databases

BioMutaiPSG5.
DMDMi311033414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001491235 – 335Pregnancy-specific beta-1-glycoprotein 5Add BLAST301

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi169 ↔ 217Curated
Glycosylationi175N-linked (GlcNAc...)Sequence analysis1
Glycosylationi210N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi261 ↔ 301Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15238.
PeptideAtlasiQ15238.
PRIDEiQ15238.

PTM databases

iPTMnetiQ15238.
PhosphoSitePlusiQ15238.

Expressioni

Tissue specificityi

Synthesized by syncytiotrophoblast of the placenta.

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiENSG00000204941.
CleanExiHS_PSG5.
ExpressionAtlasiQ15238. baseline and differential.
GenevisibleiQ15238. HS.

Organism-specific databases

HPAiHPA046327.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TIE1P355903EBI-4314891,EBI-2256865

Protein-protein interaction databases

BioGridi111648. 3 interactors.
IntActiQ15238. 2 interactors.
MINTiMINT-1196995.

Structurei

3D structure databases

ProteinModelPortaliQ15238.
SMRiQ15238.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 144Ig-like V-typeAdd BLAST110
Domaini147 – 234Ig-like C2-type 1Add BLAST88
Domaini239 – 317Ig-like C2-type 2Add BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi127 – 129Cell attachment siteSequence analysis3

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ15238.
KOiK06500.
PhylomeDBiQ15238.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLSAPPCT QHITWKGLLL TASLLNFWNL PITAQVTIEA LPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLAGYIWYKG QLMDLYHYIT SYVVDGQINI YGPAYTGRET
110 120 130 140 150
VYSNASLLIQ NVTREDAGSY TLHIIKRGDR TRGVTGYFTF NLYLKLPKPY
160 170 180 190 200
ITINNSKPRE NKDVLAFTCE PKSENYTYIW WLNGQSLPVS PRVKRPIENR
210 220 230 240 250
ILILPSVTRN ETGPYECEIR DRDGGMRSDP VTLNVLYGPD LPSIYPSFTY
260 270 280 290 300
YRSGENLYLS CFAESNPPAE YFWTINGKFQ QSGQKLSIPQ ITTKHRGLYT
310 320 330
CSVRNSATGK ESSKSMTVEV SAPSGIGRLP LLNPI
Length:335
Mass (Da):37,713
Last modified:November 2, 2010 - v3
Checksum:iE14EA6E9DAA88296
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15W → C in AAA60205 (PubMed:1922019).Curated1
Sequence conflicti20L → V in AAA36514 (PubMed:2735907).Curated1
Sequence conflicti195R → Q no nucleotide entry (PubMed:2789512).Curated1
Sequence conflicti195R → Q in AAH12607 (PubMed:15489334).Curated1
Sequence conflicti232T → S in AAA60205 (PubMed:1922019).Curated1
Sequence conflicti232T → S in AAA36514 (PubMed:2735907).Curated1
Sequence conflicti240D → Y in AAA36514 (PubMed:2735907).Curated1
Sequence conflicti288I → M in AAA36514 (PubMed:2735907).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06026018L → V.4 PublicationsCorresponds to variant rs8107936dbSNPEnsembl.1
Natural variantiVAR_016041154N → K.2 PublicationsCorresponds to variant rs1058259dbSNPEnsembl.1
Natural variantiVAR_060261168T → I.Corresponds to variant rs5013158dbSNPEnsembl.1
Natural variantiVAR_060262227R → H.4 PublicationsCorresponds to variant rs1058285dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73713 mRNA. Translation: AAA60205.1.
M25384 mRNA. Translation: AAA36514.1.
AC005392 Genomic DNA. No translation available.
BC012607 mRNA. Translation: AAH12607.1.
AH007626 Genomic DNA. Translation: AAD28500.1.
CCDSiCCDS12617.1.
PIRiA33514.
B33251.
C54312.
RefSeqiNP_001123486.1. NM_001130014.1.
NP_002772.3. NM_002781.3.
XP_016882492.1. XM_017027003.1.
UniGeneiHs.654415.

Genome annotation databases

EnsembliENST00000342951; ENSP00000344413; ENSG00000204941.
ENST00000366175; ENSP00000382334; ENSG00000204941.
ENST00000407356; ENSP00000386008; ENSG00000204941.
GeneIDi5673.
KEGGihsa:5673.
UCSCiuc002ovu.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73713 mRNA. Translation: AAA60205.1.
M25384 mRNA. Translation: AAA36514.1.
AC005392 Genomic DNA. No translation available.
BC012607 mRNA. Translation: AAH12607.1.
AH007626 Genomic DNA. Translation: AAD28500.1.
CCDSiCCDS12617.1.
PIRiA33514.
B33251.
C54312.
RefSeqiNP_001123486.1. NM_001130014.1.
NP_002772.3. NM_002781.3.
XP_016882492.1. XM_017027003.1.
UniGeneiHs.654415.

3D structure databases

ProteinModelPortaliQ15238.
SMRiQ15238.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111648. 3 interactors.
IntActiQ15238. 2 interactors.
MINTiMINT-1196995.

PTM databases

iPTMnetiQ15238.
PhosphoSitePlusiQ15238.

Polymorphism and mutation databases

BioMutaiPSG5.
DMDMi311033414.

Proteomic databases

PaxDbiQ15238.
PeptideAtlasiQ15238.
PRIDEiQ15238.

Protocols and materials databases

DNASUi5673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342951; ENSP00000344413; ENSG00000204941.
ENST00000366175; ENSP00000382334; ENSG00000204941.
ENST00000407356; ENSP00000386008; ENSG00000204941.
GeneIDi5673.
KEGGihsa:5673.
UCSCiuc002ovu.4. human.

Organism-specific databases

CTDi5673.
DisGeNETi5673.
GeneCardsiPSG5.
H-InvDBHIX0096869.
HGNCiHGNC:9522. PSG5.
HPAiHPA046327.
MIMi176394. gene.
neXtProtiNX_Q15238.
OpenTargetsiENSG00000204941.
PharmGKBiPA33867.
GenAtlasiSearch...

Phylogenomic databases

GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ15238.
KOiK06500.
PhylomeDBiQ15238.
TreeFamiTF336859.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000170848-MONOMER.

Miscellaneous databases

GeneWikiiPSG5.
GenomeRNAii5673.
PROiQ15238.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000204941.
CleanExiHS_PSG5.
ExpressionAtlasiQ15238. baseline and differential.
GenevisibleiQ15238. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPSG5_HUMAN
AccessioniPrimary (citable) accession number: Q15238
Secondary accession number(s): Q15239, Q96QJ1, Q9UQ75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: November 2, 2016
This is version 149 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.