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Protein

Pregnancy-specific beta-1-glycoprotein 5

Gene

PSG5

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  1. female pregnancy Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pregnancy-specific beta-1-glycoprotein 5
Short name:
PS-beta-G-5
Short name:
PSBG-5
Short name:
Pregnancy-specific glycoprotein 5
Alternative name(s):
Fetal liver non-specific cross-reactive antigen 3
Short name:
FL-NCA-3
Gene namesi
Name:PSG5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9522. PSG5.

Subcellular locationi

  1. Secreted Curated

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33867.

Polymorphism and mutation databases

BioMutaiPSG5.
DMDMi311033414.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Sequence AnalysisAdd
BLAST
Chaini35 – 335301Pregnancy-specific beta-1-glycoprotein 5PRO_0000014912Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence Analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi169 ↔ 217Curated
Glycosylationi175 – 1751N-linked (GlcNAc...)Sequence Analysis
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi261 ↔ 301Curated

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ15238.
PRIDEiQ15238.

PTM databases

PhosphoSiteiQ15238.

Expressioni

Tissue specificityi

Synthesized by syncytiotrophoblast of the placenta.

Developmental stagei

PSBG are produced in high quantity during pregnancy.

Gene expression databases

BgeeiQ15238.
CleanExiHS_PSG5.
ExpressionAtlasiQ15238. baseline and differential.
GenevestigatoriQ15238.

Organism-specific databases

HPAiHPA046327.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
TIE1P355903EBI-4314891,EBI-2256865

Protein-protein interaction databases

BioGridi111648. 3 interactions.
IntActiQ15238. 2 interactions.
MINTiMINT-1196995.
STRINGi9606.ENSP00000344413.

Structurei

3D structure databases

ProteinModelPortaliQ15238.
SMRiQ15238. Positions 34-318.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 144110Ig-like V-typeAdd
BLAST
Domaini147 – 23488Ig-like C2-type 1Add
BLAST
Domaini239 – 31779Ig-like C2-type 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi127 – 1293Cell attachment siteSequence Analysis

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG4475.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ15238.
KOiK06500.
OrthoDBiEOG74BJS7.
PhylomeDBiQ15238.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15238-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPLSAPPCT QHITWKGLLL TASLLNFWNL PITAQVTIEA LPPKVSEGKD
60 70 80 90 100
VLLLVHNLPQ NLAGYIWYKG QLMDLYHYIT SYVVDGQINI YGPAYTGRET
110 120 130 140 150
VYSNASLLIQ NVTREDAGSY TLHIIKRGDR TRGVTGYFTF NLYLKLPKPY
160 170 180 190 200
ITINNSKPRE NKDVLAFTCE PKSENYTYIW WLNGQSLPVS PRVKRPIENR
210 220 230 240 250
ILILPSVTRN ETGPYECEIR DRDGGMRSDP VTLNVLYGPD LPSIYPSFTY
260 270 280 290 300
YRSGENLYLS CFAESNPPAE YFWTINGKFQ QSGQKLSIPQ ITTKHRGLYT
310 320 330
CSVRNSATGK ESSKSMTVEV SAPSGIGRLP LLNPI
Length:335
Mass (Da):37,713
Last modified:November 2, 2010 - v3
Checksum:iE14EA6E9DAA88296
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti15 – 151W → C in AAA60205 (PubMed:1922019).Curated
Sequence conflicti20 – 201L → V in AAA36514 (PubMed:2735907).Curated
Sequence conflicti195 – 1951R → Q no nucleotide entry (PubMed:2789512).Curated
Sequence conflicti195 – 1951R → Q in AAH12607 (PubMed:15489334).Curated
Sequence conflicti232 – 2321T → S in AAA60205 (PubMed:1922019).Curated
Sequence conflicti232 – 2321T → S in AAA36514 (PubMed:2735907).Curated
Sequence conflicti240 – 2401D → Y in AAA36514 (PubMed:2735907).Curated
Sequence conflicti288 – 2881I → M in AAA36514 (PubMed:2735907).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti18 – 181L → V.4 Publications
Corresponds to variant rs8107936 [ dbSNP | Ensembl ].
VAR_060260
Natural varianti154 – 1541N → K.2 Publications
Corresponds to variant rs1058259 [ dbSNP | Ensembl ].
VAR_016041
Natural varianti168 – 1681T → I.
Corresponds to variant rs5013158 [ dbSNP | Ensembl ].
VAR_060261
Natural varianti227 – 2271R → H.4 Publications
Corresponds to variant rs1058285 [ dbSNP | Ensembl ].
VAR_060262

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73713 mRNA. Translation: AAA60205.1.
M25384 mRNA. Translation: AAA36514.1.
AC005392 Genomic DNA. No translation available.
BC012607 mRNA. Translation: AAH12607.1.
AH007626 Genomic DNA. Translation: AAD28500.1.
CCDSiCCDS12617.1.
PIRiA33514.
B33251.
C54312.
RefSeqiNP_001123486.1. NM_001130014.1.
NP_002772.3. NM_002781.3.
UniGeneiHs.654415.

Genome annotation databases

EnsembliENST00000342951; ENSP00000344413; ENSG00000204941.
ENST00000366175; ENSP00000382334; ENSG00000204941.
ENST00000407356; ENSP00000386008; ENSG00000204941.
GeneIDi5673.
KEGGihsa:5673.
UCSCiuc002ovu.3. human.

Polymorphism and mutation databases

BioMutaiPSG5.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73713 mRNA. Translation: AAA60205.1.
M25384 mRNA. Translation: AAA36514.1.
AC005392 Genomic DNA. No translation available.
BC012607 mRNA. Translation: AAH12607.1.
AH007626 Genomic DNA. Translation: AAD28500.1.
CCDSiCCDS12617.1.
PIRiA33514.
B33251.
C54312.
RefSeqiNP_001123486.1. NM_001130014.1.
NP_002772.3. NM_002781.3.
UniGeneiHs.654415.

3D structure databases

ProteinModelPortaliQ15238.
SMRiQ15238. Positions 34-318.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111648. 3 interactions.
IntActiQ15238. 2 interactions.
MINTiMINT-1196995.
STRINGi9606.ENSP00000344413.

PTM databases

PhosphoSiteiQ15238.

Polymorphism and mutation databases

BioMutaiPSG5.
DMDMi311033414.

Proteomic databases

PaxDbiQ15238.
PRIDEiQ15238.

Protocols and materials databases

DNASUi5673.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000342951; ENSP00000344413; ENSG00000204941.
ENST00000366175; ENSP00000382334; ENSG00000204941.
ENST00000407356; ENSP00000386008; ENSG00000204941.
GeneIDi5673.
KEGGihsa:5673.
UCSCiuc002ovu.3. human.

Organism-specific databases

CTDi5673.
GeneCardsiGC19M043670.
H-InvDBHIX0096869.
HGNCiHGNC:9522. PSG5.
HPAiHPA046327.
MIMi176394. gene.
neXtProtiNX_Q15238.
PharmGKBiPA33867.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4475.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiQ15238.
KOiK06500.
OrthoDBiEOG74BJS7.
PhylomeDBiQ15238.
TreeFamiTF336859.

Miscellaneous databases

GeneWikiiPSG5.
GenomeRNAii5673.
NextBioi22034.
PROiQ15238.
SOURCEiSearch...

Gene expression databases

BgeeiQ15238.
CleanExiHS_PSG5.
ExpressionAtlasiQ15238. baseline and differential.
GenevestigatoriQ15238.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene."
    Oikawa S., Inuzuka C., Kuroki M., Matsuoka Y., Kosaki G., Nakazato H.
    Biochem. Biophys. Res. Commun. 163:1021-1031(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS VAL-18 AND HIS-227.
    Tissue: Placenta.
  2. "Characterization of new members of the pregnancy-specific beta 1-glycoprotein family."
    Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.
    Mol. Cell. Biochem. 106:161-170(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-18; LYS-154 AND HIS-227.
    Tissue: Placenta.
  3. "Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement."
    Khan W.N., Hammarstroem S.
    Biochem. Biophys. Res. Commun. 161:525-535(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-18; LYS-154 AND HIS-227.
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-18 AND HIS-227.
    Tissue: Placenta.
  6. "Characterization of upstream promotor region, exon 1 and exon 2 of the PSG gene family."
    Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
    Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
  7. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiPSG5_HUMAN
AccessioniPrimary (citable) accession number: Q15238
Secondary accession number(s): Q15239, Q96QJ1, Q9UQ75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: April 29, 2015
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.