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Q15238 (PSG5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 132. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Pregnancy-specific beta-1-glycoprotein 5

Short name=PS-beta-G-5
Short name=PSBG-5
Short name=Pregnancy-specific glycoprotein 5
Alternative name(s):
Fetal liver non-specific cross-reactive antigen 3
Short name=FL-NCA-3
Gene names
Name:PSG5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length335 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Secreted Potential.

Tissue specificity

Synthesized by syncytiotrophoblast of the placenta.

Developmental stage

PSBG are produced in high quantity during pregnancy.

Sequence similarities

Belongs to the immunoglobulin superfamily. CEA family.

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 Ig-like V-type (immunoglobulin-like) domain.

Ontologies

Keywords
   Cellular componentSecreted
   Coding sequence diversityPolymorphism
   DomainImmunoglobulin domain
Repeat
Signal
   PTMDisulfide bond
Glycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processfemale pregnancy

Traceable author statement PubMed 1690992. Source: ProtInc

   Cellular_componentextracellular region

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionprotein binding

Inferred from physical interaction PubMed 21982860. Source: IntAct

Complete GO annotation...

Binary interactions

With

Entry

#Exp.

IntAct

Notes

TIE1P355903EBI-4314891,EBI-2256865

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 3434 Potential
Chain35 – 335301Pregnancy-specific beta-1-glycoprotein 5
PRO_0000014912

Regions

Domain35 – 144110Ig-like V-type
Domain147 – 23488Ig-like C2-type 1
Domain239 – 31779Ig-like C2-type 2
Motif127 – 1293Cell attachment site Potential

Amino acid modifications

Glycosylation1041N-linked (GlcNAc...) Potential
Glycosylation1111N-linked (GlcNAc...) Potential
Glycosylation1751N-linked (GlcNAc...) Potential
Glycosylation2101N-linked (GlcNAc...) Potential
Disulfide bond169 ↔ 217 Probable
Disulfide bond261 ↔ 301 Probable

Natural variations

Natural variant181L → V. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs8107936 [ dbSNP | Ensembl ].
VAR_060260
Natural variant1541N → K. Ref.2 Ref.3
Corresponds to variant rs1058259 [ dbSNP | Ensembl ].
VAR_016041
Natural variant1681T → I.
Corresponds to variant rs5013158 [ dbSNP | Ensembl ].
VAR_060261
Natural variant2271R → H. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs1058285 [ dbSNP | Ensembl ].
VAR_060262

Experimental info

Sequence conflict151W → C in AAA60205. Ref.2
Sequence conflict201L → V in AAA36514. Ref.3
Sequence conflict1951R → Q no nucleotide entry Ref.1
Sequence conflict1951R → Q in AAH12607. Ref.5
Sequence conflict2321T → S in AAA60205. Ref.2
Sequence conflict2321T → S in AAA36514. Ref.3
Sequence conflict2401D → Y in AAA36514. Ref.3
Sequence conflict2881I → M in AAA36514. Ref.3

Sequences

Sequence LengthMass (Da)Tools
Q15238 [UniParc].

Last modified November 2, 2010. Version 3.
Checksum: E14EA6E9DAA88296

FASTA33537,713
        10         20         30         40         50         60 
MGPLSAPPCT QHITWKGLLL TASLLNFWNL PITAQVTIEA LPPKVSEGKD VLLLVHNLPQ 

        70         80         90        100        110        120 
NLAGYIWYKG QLMDLYHYIT SYVVDGQINI YGPAYTGRET VYSNASLLIQ NVTREDAGSY 

       130        140        150        160        170        180 
TLHIIKRGDR TRGVTGYFTF NLYLKLPKPY ITINNSKPRE NKDVLAFTCE PKSENYTYIW 

       190        200        210        220        230        240 
WLNGQSLPVS PRVKRPIENR ILILPSVTRN ETGPYECEIR DRDGGMRSDP VTLNVLYGPD 

       250        260        270        280        290        300 
LPSIYPSFTY YRSGENLYLS CFAESNPPAE YFWTINGKFQ QSGQKLSIPQ ITTKHRGLYT 

       310        320        330 
CSVRNSATGK ESSKSMTVEV SAPSGIGRLP LLNPI 

« Hide

References

« Hide 'large scale' references
[1]"A pregnancy-specific beta 1-glycoprotein, a CEA gene family member, expressed in a human promyelocytic leukemia cell line, HL-60: structures of protein, mRNA and gene."
Oikawa S., Inuzuka C., Kuroki M., Matsuoka Y., Kosaki G., Nakazato H.
Biochem. Biophys. Res. Commun. 163:1021-1031(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], VARIANTS VAL-18 AND HIS-227.
Tissue: Placenta.
[2]"Characterization of new members of the pregnancy-specific beta 1-glycoprotein family."
Chan W.Y., Zheng Q.X., McMahon J., Tease L.A.
Mol. Cell. Biochem. 106:161-170(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANTS VAL-18; LYS-154 AND HIS-227.
Tissue: Placenta.
[3]"Carcinoembryonic antigen gene family: molecular cloning of cDNA for a PS-beta-G/FL-NCA glycoprotein with a novel domain arrangement."
Khan W.N., Hammarstroem S.
Biochem. Biophys. Res. Commun. 161:525-535(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS VAL-18; LYS-154 AND HIS-227.
[4]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANTS VAL-18 AND HIS-227.
Tissue: Placenta.
[6]"Characterization of upstream promotor region, exon 1 and exon 2 of the PSG gene family."
Fraengsmyr L., Teglund S., Israelsson A., Hammarstroem S.
Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-143.
[7]"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M73713 mRNA. Translation: AAA60205.1.
M25384 mRNA. Translation: AAA36514.1.
AC005392 Genomic DNA. No translation available.
BC012607 mRNA. Translation: AAH12607.1.
AH007626 Genomic DNA. Translation: AAD28500.1.
CCDSCCDS12617.1.
PIRA33514.
B33251.
C54312.
RefSeqNP_001123486.1. NM_001130014.1.
NP_002772.3. NM_002781.3.
UniGeneHs.654415.

3D structure databases

ProteinModelPortalQ15238.
SMRQ15238. Positions 34-330.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid111648. 2 interactions.
IntActQ15238. 2 interactions.
MINTMINT-1196995.
STRING9606.ENSP00000344413.

PTM databases

PhosphoSiteQ15238.

Polymorphism databases

DMDM311033414.

Proteomic databases

PaxDbQ15238.
PRIDEQ15238.

Protocols and materials databases

DNASU5673.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000342951; ENSP00000344413; ENSG00000204941.
ENST00000366175; ENSP00000382334; ENSG00000204941.
ENST00000407356; ENSP00000386008; ENSG00000204941.
GeneID5673.
KEGGhsa:5673.
UCSCuc002ovu.3. human.

Organism-specific databases

CTD5673.
GeneCardsGC19M043670.
H-InvDBHIX0096869.
HGNCHGNC:9522. PSG5.
HPAHPA046327.
MIM176394. gene.
neXtProtNX_Q15238.
PharmGKBPA33867.
GenAtlasSearch...

Phylogenomic databases

eggNOGKOG4475.
HOGENOMHOG000233417.
HOVERGENHBG007922.
KOK06500.
OrthoDBEOG74BJS7.
PhylomeDBQ15238.
TreeFamTF336859.

Gene expression databases

ArrayExpressQ15238.
BgeeQ15238.
CleanExHS_PSG5.
GenevestigatorQ15238.

Family and domain databases

Gene3D2.60.40.10. 3 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 1 hit.
[Graphical view]
SMARTSM00409. IG. 2 hits.
SM00408. IGc2. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiPSG5.
GenomeRNAi5673.
NextBio22034.
PROQ15238.
SOURCESearch...

Entry information

Entry namePSG5_HUMAN
AccessionPrimary (citable) accession number: Q15238
Secondary accession number(s): Q15239, Q96QJ1, Q9UQ75
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 2, 2010
Last modified: July 9, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM