Q15198 (PGFRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Platelet-derived growth factor receptor-like protein
Short name=PDGFR-like protein

Alternative name(s):
PDGF receptor beta-like tumor suppressor

Gene names

Name:	PDGFRL
Synonyms:	PRLTS

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	375 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Forms a complex composed of PDGFRL, TNK2 and GRB2.
Subcellular location	Secreted Probable.
Tissue specificity	Expressed in colon, lung and liver. Ref.1
Involvement in disease	Defects in PDGFRL are associated with colorectal cancer (CRC) [MIM:114500]. Ref.1
Sequence similarities	Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Ontologies

Keywords
Cellular component	Secreted
Disease	Disease mutation
Domain	Immunoglobulin domain Repeat Signal
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	platelet activating factor receptor activity Traceable author statement. Source: ProtInc platelet-derived growth factor beta-receptor activity Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 21	21	Potential
	Chain	22 – 375	354	Platelet-derived growth factor receptor-like protein		PRO_0000233090
Regions
	Domain	62 – 159	98	Ig-like C2-type 1
	Domain	272 – 375	104	Ig-like C2-type 2
Amino acid modifications
	Glycosylation	132	1	N-linked (GlcNAc...) Potential
	Glycosylation	219	1	N-linked (GlcNAc...) Potential
	Disulfide bond	96 ↔ 143		By similarity
	Disulfide bond	293 ↔ 357		By similarity
Natural variations
	Natural variant	23	1	H → Y in CRC; somatic mutation. Ref.1		VAR_026052
Experimental info
	Sequence conflict	227	1	M → I in CAG46750. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q15198 [UniParc]. Last modified November 1, 1996. Version 1. Checksum: DF7FE6EB3FB2A802	FASTA	375	41,861
	10 20 30 40 50 60 MKVWLLLGLL LVHEALEDVT GQHLPKNKRP KEPGENRIKP TNKKVKPKIP KMKDRDSANS 70 80 90 100 110 120 APKTQSIMMQ VLDKGRFQKP AATLSLLAGQ TVELRCKGSR IGWSYPAYLD TFKDSRLSVK 130 140 150 160 170 180 QNERYGQLTL VNSTSADTGE FSCWVQLCSG YICRKDEAKT GSTYIFFTEK GELFVPSPSY 190 200 210 220 230 240 FDVVYLNPDR QAVVPCRVTV LSAKVTLHRE FPAKEIPANG TDIVYDMKRG FVYLQPHSEH 250 260 270 280 290 300 QGVVYCRAEA GGRSQISVKY QLLYVAVPSG PPSTTILASS NKVKSGDDIS VLCTVLGEPD 310 320 330 340 350 360 VEVEFTWIFP GQKDERPVTI QDTWRLIHRG LGHTTRISQS VITVEDFETI DAGYYICTAQ 370 NLQGQTTVAT TVEFS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene." Fujiwara Y., Ohata H., Kuroki T., Koyama K., Tsuchiya E., Monden M., Nakamura Y. Oncogene 10:891-895(1995) [PubMed: 7898930] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT CRC TYR-23, TISSUE SPECIFICITY. Tissue: Fetal lung.
[2]	"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Urinary bladder.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[6]	"Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling." Pao-Chun L., Chan P.M., Chan W., Manser E. J. Biol. Chem. 284:34954-34963(2009) [PubMed: 19815557] [Abstract] Cited for: INTERACTION WITH GRB2 AND TNK2.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D37965 mRNA. Translation: BAA07179.1. CR541952 mRNA. Translation: CAG46750.1. AK289450 mRNA. Translation: BAF82139.1. CH471080 Genomic DNA. Translation: EAW63811.1. BC010927 mRNA. Translation: AAH10927.1.
IPI	IPI00006236.
PIR	I60125.
RefSeq	NP_006198.1. NM_006207.2.
UniGene	Hs.458573.
3D structure databases
ProteinModelPortal	Q15198.
SMR	Q15198. Positions 73-147, 168-375.
ModBase	Search...
Protein-protein interaction databases
STRING	Q15198.
PTM databases
PhosphoSite	Q15198.
Polymorphism databases
DMDM	74762141.
Proteomic databases
PRIDE	Q15198.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000251630; ENSP00000251630; ENSG00000104213. ENST00000398074; ENSP00000381149; ENSG00000104213.
GeneID	5157.
KEGG	hsa:5157.
UCSC	uc003wxr.2. human.
Organism-specific databases
CTD	5157.
GeneCards	GC08P017436.
H-InvDB	HIX0007339.
HGNC	HGNC:8805. PDGFRL.
MIM	114500. phenotype. 604584. gene.
neXtProt	NX_Q15198.
Orphanet	144. Hereditary nonpolyposis colon cancer.
PharmGKB	PA33149.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG06816.
GeneTree	ENSGT00390000017153.
HOGENOM	HBG714553.
HOVERGEN	HBG053893.
InParanoid	Q15198.
OMA	DFETIDA.
OrthoDB	EOG4BG8W8.
PhylomeDB	Q15198.
Gene expression databases
ArrayExpress	Q15198.
Bgee	Q15198.
CleanEx	HS_PDGFRL.
Genevestigator	Q15198.
GermOnline	ENSG00000104213. Homo sapiens.
Family and domain databases
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. [Graphical view]
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 3 hits.
Pfam	PF07679. I-set. 1 hit. [Graphical view]
SMART	SM00409. IG. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 2 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	19950.
SOURCE	Search...

Entry information

Entry name

PGFRL_HUMAN

Accession

Primary (citable) accession number: Q15198
Secondary accession number(s): A8K085, Q6FH04

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 2, 2006
Last sequence update:	November 1, 1996
Last modified:	January 25, 2012
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.