Q15198 (PGFRL_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 98.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Platelet-derived growth factor receptor-like protein Short name=PDGFR-like protein Alternative name(s): PDGF receptor beta-like tumor suppressor | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 375 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Subunit structure | Forms a complex composed of PDGFRL, TNK2 and GRB2. |
| Subcellular location | Secreted Probable. |
| Tissue specificity | Expressed in colon, lung and liver. Ref.1 |
| Involvement in disease | Defects in PDGFRL are associated with colorectal cancer (CRC) [MIM:114500]. Ref.1 |
| Sequence similarities | Contains 2 Ig-like C2-type (immunoglobulin-like) domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Secreted |
| Disease | Disease mutation |
| Domain | Immunoglobulin domain Repeat Signal |
| PTM | Disulfide bond Glycoprotein |
| Technical term | Complete proteome Reference proteome |
| Gene Ontology (GO) | |
| Cellular component | extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | platelet activating factor receptor activity Traceable author statement. Source: ProtInc platelet-derived growth factor beta-receptor activityTraceable author statement. Source: ProtInc |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 21 | 21 | Potential | ||||||||
| Chain | 22 – 375 | 354 | Platelet-derived growth factor receptor-like protein | PRO_0000233090 | |||||||
Regions | |||||||||||
| Domain | 62 – 159 | 98 | Ig-like C2-type 1 | ||||||||
| Domain | 272 – 375 | 104 | Ig-like C2-type 2 | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 132 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 219 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 96 ↔ 143 | By similarity | |||||||||
| Disulfide bond | 293 ↔ 357 | By similarity | |||||||||
Natural variations | |||||||||||
| Natural variant | 23 | 1 | H → Y in CRC; somatic mutation. Ref.1 | VAR_026052 | |||||||
Experimental info | |||||||||||
| Sequence conflict | 227 | 1 | M → I in CAG46750. Ref.2 | ||||||||
Sequences
| ||||||||||||||||||
References
| « Hide 'large scale' references | |
| [1] | "Isolation of a candidate tumor suppressor gene on chromosome 8p21.3-p22 that is homologous to an extracellular domain of the PDGF receptor beta gene." Fujiwara Y., Ohata H., Kuroki T., Koyama K., Tsuchiya E., Monden M., Nakamura Y. Oncogene 10:891-895(1995) [PubMed: 7898930] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT CRC TYR-23, TISSUE SPECIFICITY. Tissue: Fetal lung. |
| [2] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [3] | "Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. Sugano S.Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Urinary bladder. |
| [4] | Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C.Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [5] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain. |
| [6] | "Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling." Pao-Chun L., Chan P.M., Chan W., Manser E. J. Biol. Chem. 284:34954-34963(2009) [PubMed: 19815557] [Abstract] Cited for: INTERACTION WITH GRB2 AND TNK2. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | D37965 mRNA. Translation: BAA07179.1. CR541952 mRNA. Translation: CAG46750.1. AK289450 mRNA. Translation: BAF82139.1. CH471080 Genomic DNA. Translation: EAW63811.1. BC010927 mRNA. Translation: AAH10927.1. |
| IPI | IPI00006236. |
| PIR | I60125. |
| RefSeq | NP_006198.1. NM_006207.2. |
| UniGene | Hs.458573. |
3D structure databases | |
| ProteinModelPortal | Q15198. |
| SMR | Q15198. Positions 73-147, 168-375. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q15198. |
PTM databases | |
| PhosphoSite | Q15198. |
Polymorphism databases | |
| DMDM | 74762141. |
Proteomic databases | |
| PRIDE | Q15198. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| Ensembl | ENST00000251630; ENSP00000251630; ENSG00000104213. ENST00000398074; ENSP00000381149; ENSG00000104213. |
| GeneID | 5157. |
| KEGG | hsa:5157. |
| UCSC | uc003wxr.2. human. |
Organism-specific databases | |
| CTD | 5157. |
| GeneCards | GC08P017436. |
| H-InvDB | HIX0007339. |
| HGNC | HGNC:8805. PDGFRL. |
| MIM | 114500. phenotype. 604584. gene. |
| neXtProt | NX_Q15198. |
| Orphanet | 144. Hereditary nonpolyposis colon cancer. |
| PharmGKB | PA33149. |
| GenAtlas | Search... |
Phylogenomic databases | |
| eggNOG | prNOG06816. |
| GeneTree | ENSGT00390000017153. |
| HOGENOM | HBG714553. |
| HOVERGEN | HBG053893. |
| InParanoid | Q15198. |
| OMA | DFETIDA. |
| OrthoDB | EOG4BG8W8. |
| PhylomeDB | Q15198. |
Gene expression databases | |
| ArrayExpress | Q15198. |
| Bgee | Q15198. |
| CleanEx | HS_PDGFRL. |
| Genevestigator | Q15198. |
| GermOnline | ENSG00000104213. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR013098. Ig_I-set. IPR003599. Ig_sub. [Graphical view] |
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 3 hits. |
| Pfam | PF07679. I-set. 1 hit. [Graphical view] |
| SMART | SM00409. IG. 2 hits. [Graphical view] |
| PROSITE | PS50835. IG_LIKE. 2 hits. [Graphical view] |
| ProtoNet | Search... |
Other | |
| NextBio | 19950. |
| SOURCE | Search... |
Entry information
| Entry name | PGFRL_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q15198 Secondary accession number(s): A8K085, Q6FH04 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 8 Human chromosome 8: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with