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Protein

Inorganic pyrophosphatase

Gene

PPA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Diphosphate + H2O = 2 phosphate.

Cofactori

Mg2+By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi116Magnesium 1By similarity1
Metal bindingi121Magnesium 1By similarity1
Metal bindingi121Magnesium 2By similarity1
Metal bindingi153Magnesium 1By similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandMagnesium, Metal-binding

Enzyme and pathway databases

BRENDAi3.6.1.1 2681
ReactomeiR-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-71737 Pyrophosphate hydrolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Inorganic pyrophosphatase (EC:3.6.1.1)
Alternative name(s):
Pyrophosphate phospho-hydrolase
Short name:
PPase
Gene namesi
Name:PPA1
Synonyms:IOPPP, PP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

EuPathDBiHostDB:ENSG00000180817.11
HGNCiHGNC:9226 PPA1
MIMi179030 gene
neXtProtiNX_Q15181

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

Pathology & Biotechi

Organism-specific databases

DisGeNETi5464
OpenTargetsiENSG00000180817
PharmGKBiPA33550

Polymorphism and mutation databases

BioMutaiPPA1
DMDMi8247940

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001375672 – 289Inorganic pyrophosphataseAdd BLAST288

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineCombined sources1
Modified residuei57N6-acetyllysineCombined sources1
Modified residuei228N6-acetyllysineCombined sources1
Modified residuei250PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ15181
PaxDbiQ15181
PeptideAtlasiQ15181
PRIDEiQ15181
ProteomicsDBi60485
TopDownProteomicsiQ15181

2D gel databases

REPRODUCTION-2DPAGEiIPI00015018

PTM databases

iPTMnetiQ15181
PhosphoSitePlusiQ15181

Expressioni

Tissue specificityi

Expressed ubiquitously.1 Publication

Gene expression databases

BgeeiENSG00000180817
CleanExiHS_PPA1
ExpressionAtlasiQ15181 baseline and differential
GenevisibleiQ15181 HS

Organism-specific databases

HPAiHPA019878
HPA020096

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

BioGridi111460, 45 interactors
IntActiQ15181, 13 interactors
MINTiQ15181
STRINGi9606.ENSP00000362329

Structurei

3D structure databases

ProteinModelPortaliQ15181
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PPase family.Curated

Phylogenomic databases

eggNOGiKOG1626 Eukaryota
COG0221 LUCA
GeneTreeiENSGT00390000017004
HOGENOMiHOG000195569
HOVERGENiHBG000491
InParanoidiQ15181
KOiK01507
OMAiKLRYVRN
OrthoDBiEOG091G0KFV
PhylomeDBiQ15181
TreeFamiTF300887

Family and domain databases

CDDicd00412 pyrophosphatase, 1 hit
Gene3Di3.90.80.10, 1 hit
InterProiView protein in InterPro
IPR008162 Pyrophosphatase
IPR036649 Pyrophosphatase_sf
PANTHERiPTHR10286 PTHR10286, 1 hit
PfamiView protein in Pfam
PF00719 Pyrophosphatase, 1 hit
SUPFAMiSSF50324 SSF50324, 1 hit
PROSITEiView protein in PROSITE
PS00387 PPASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15181-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSGFSTEERA APFSLEYRVF LKNEKGQYIS PFHDIPIYAD KDVFHMVVEV
60 70 80 90 100
PRWSNAKMEI ATKDPLNPIK QDVKKGKLRY VANLFPYKGY IWNYGAIPQT
110 120 130 140 150
WEDPGHNDKH TGCCGDNDPI DVCEIGSKVC ARGEIIGVKV LGILAMIDEG
160 170 180 190 200
ETDWKVIAIN VDDPDAANYN DINDVKRLKP GYLEATVDWF RRYKVPDGKP
210 220 230 240 250
ENEFAFNAEF KDKDFAIDII KSTHDHWKAL VTKKTNGKGI SCMNTTLSES
260 270 280
PFKCDPDAAR AIVDALPPPC ESACTVPTDV DKWFHHQKN
Length:289
Mass (Da):32,660
Last modified:May 30, 2000 - v2
Checksum:iE3973C9E6F8CA5CD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti12P → A in AAD24964 (Ref. 8) Curated1
Sequence conflicti84L → I in CAA88494 (Ref. 10) Curated1
Sequence conflicti96 – 97AI → TL in CAA88494 (Ref. 10) Curated2
Sequence conflicti105 – 114GHNDKHTGCC → HEKDKSTNCF in CAA88494 (Ref. 10) Curated10
Sequence conflicti129 – 140VCARG…IGVKV → ILSCGEVIHVKI in CAA88494 (Ref. 10) CuratedAdd BLAST12
Sequence conflicti146M → L in CAA88494 (Ref. 10) Curated1
Sequence conflicti156V → L in CAA88494 (Ref. 10) Curated1
Sequence conflicti161 – 162VD → AN in CAA88494 (Ref. 10) Curated2
Sequence conflicti165 – 173DAANYNDIN → EASKFHDID in CAA88494 (Ref. 10) Curated9
Sequence conflicti177 – 178RL → KF in CAA88494 (Ref. 10) Curated2
Sequence conflicti187 – 188VD → LN in CAA88494 (Ref. 10) Curated2
Sequence conflicti192R → L in CAA88494 (Ref. 10) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03635857K → N in a breast cancer sample; somatic mutation. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF154065 mRNA Translation: AAD34643.1
AB026723 mRNA Translation: BAA84702.1
AF217186 mRNA Translation: AAG36780.1
AF092439 mRNA Translation: AAP97214.1
AF119665 mRNA Translation: AAF17222.1
AL731540 Genomic DNA No translation available.
BC001022 mRNA Translation: AAH01022.3
BC061581 mRNA Translation: AAH61581.2
BC105034 mRNA Translation: AAI05035.1
BC105036 mRNA Translation: AAI05037.1
BC107882 mRNA Translation: AAI07883.1
AF108211 mRNA Translation: AAD24964.1
Z48605 mRNA Translation: CAA88494.1
CCDSiCCDS7299.1
RefSeqiNP_066952.1, NM_021129.3
UniGeneiHs.437403

Genome annotation databases

EnsembliENST00000373232; ENSP00000362329; ENSG00000180817
GeneIDi5464
KEGGihsa:5464

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiIPYR_HUMAN
AccessioniPrimary (citable) accession number: Q15181
Secondary accession number(s): Q2M348
, Q5SQT7, Q6P7P4, Q9UQJ5, Q9Y5B1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 30, 2000
Last modified: June 20, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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