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Protein

Transcription elongation factor A protein-like 1

Gene

TCEAL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly.

GO - Molecular functioni

  • DNA binding transcription factor activity Source: ProtInc
  • WW domain binding Source: GO_Central

GO - Biological processi

  • negative regulation of transcription by RNA polymerase II Source: ProtInc
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription elongation factor A protein-like 1
Short name:
TCEA-like protein 1
Alternative name(s):
Nuclear phosphoprotein p21/SIIR
Transcription elongation factor S-II protein-like 1
Gene namesi
Name:TCEAL1
Synonyms:SIIR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000172465.13
HGNCiHGNC:11616 TCEAL1
MIMi300237 gene
neXtProtiNX_Q15170

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi31 – 32SS → AA: Slight decrease of transcriptional repression. 1 Publication2
Mutagenesisi36 – 37SS → AA: Loss of transcriptional repression. 1 Publication2
Mutagenesisi41 – 42SS → AA: No effect on transcriptional repression. 1 Publication2
Mutagenesisi47 – 48SS → AA: Slight decrease of transcriptional repression. 1 Publication2

Organism-specific databases

DisGeNETi9338
OpenTargetsiENSG00000172465
PharmGKBiPA36375

Polymorphism and mutation databases

BioMutaiTCEAL1
DMDMi108935936

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002392031 – 157Transcription elongation factor A protein-like 1Add BLAST157

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei31Phosphoserine1 Publication1
Modified residuei32Phosphoserine1 Publication1
Modified residuei36Phosphoserine1 Publication1
Modified residuei37Phosphoserine1 Publication1
Modified residuei41Phosphoserine1 Publication1
Modified residuei42Phosphoserine1 Publication1
Modified residuei47Phosphoserine1 Publication1
Modified residuei48Phosphoserine1 Publication1
Isoform 2 (identifier: Q15170-2)
Modified residuei28PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation of Ser-36 and Ser-37 is critical for transcriptional repression.1 Publication

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ15170
PeptideAtlasiQ15170
PRIDEiQ15170
ProteomicsDBi60479
60480 [Q15170-2]

PTM databases

iPTMnetiQ15170
PhosphoSitePlusiQ15170

Expressioni

Tissue specificityi

Expressed in all tissues examined. Highly expressed in heart, ovary, prostate and skeletal muscle. Moderately expressed in brain, placenta, testis and small intestine. Weakly expressed in lung, liver and spleen. Expressed in several cancer cell lines.1 Publication

Gene expression databases

BgeeiENSG00000172465
CleanExiHS_TCEAL1
GenevisibleiQ15170 HS

Organism-specific databases

HPAiHPA057345
HPA060384

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi114745, 58 interactors
IntActiQ15170, 20 interactors
MINTiQ15170

Structurei

3D structure databases

ProteinModelPortaliQ15170
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi15 – 72Arg/Ser-richAdd BLAST58

Sequence similaritiesi

Belongs to the TFS-II family. TFA subfamily.Curated

Phylogenomic databases

GeneTreeiENSGT00730000111084
HOGENOMiHOG000231344
HOVERGENiHBG094029
InParanoidiQ15170
OMAiERPPMEQ
OrthoDBiEOG091G13IU
PhylomeDBiQ15170
TreeFamiTF336871

Family and domain databases

InterProiView protein in InterPro
IPR010370 TCEAL1
IPR021156 TF_A-like/BEX
PANTHERiPTHR14754:SF12 PTHR14754:SF12, 1 hit
PfamiView protein in Pfam
PF04538 BEX, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q15170-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDKPRKENEE EPQSRPRPMR RGLRWSTLPK SSPPRSSLRR SSPRRRSSFL
60 70 80 90 100
RSSCLSSCLR CSSRRTPSAG LSRKDLFEGR PPMEQPPCGV GKHKLEEGSF
110 120 130 140 150
KERLARSRPQ FRGDIHGRNL SNEEMIQAAD ELEEMKRVRN KLMIMHWKAK

RSRPYPI
Length:157
Mass (Da):18,354
Last modified:May 30, 2006 - v2
Checksum:i09D86B3735283B27
GO
Isoform 2 (identifier: Q15170-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     15-69: RPRPMRRGLR...RCSSRRTPSA → APKTDEERPP...LLSEERPPQE

Show »
Length:159
Mass (Da):18,641
Checksum:iFB45224005BA6B5A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti79G → V (PubMed:8206389).Curated1
Sequence conflicti79G → V (PubMed:10051408).Curated1
Sequence conflicti94K → N (PubMed:8206389).Curated1
Sequence conflicti94K → N (PubMed:10051408).Curated1
Sequence conflicti99S → I (PubMed:8206389).Curated1
Sequence conflicti99S → I (PubMed:10051408).Curated1
Sequence conflicti148K → R (PubMed:8206389).Curated1
Sequence conflicti148K → R (PubMed:10051408).Curated1
Sequence conflicti152 – 153SR → GG (PubMed:8206389).Curated2
Sequence conflicti152 – 153SR → GG (PubMed:10051408).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_0572705R → C. Corresponds to variant dbSNP:rs34421776Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_01910815 – 69RPRPM…RTPSA → APKTDEERPPVEHSPEKQSP EEQSSEEQSSEEEFFPEELL PELLPEMLLSEERPPQE in isoform 2. 1 PublicationAdd BLAST55

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99701 mRNA Translation: AAA60149.1
AF095906 Genomic DNA Translation: AAD17840.1
AL049610 Genomic DNA No translation available.
BC000809 mRNA Translation: AAH00809.1
CCDSiCCDS35358.1 [Q15170-2]
PIRiI53785
RefSeqiNP_001006640.1, NM_001006639.1 [Q15170-2]
NP_001006641.1, NM_001006640.1 [Q15170-2]
NP_004771.2, NM_004780.2 [Q15170-2]
UniGeneiHs.95243

Genome annotation databases

EnsembliENST00000372624; ENSP00000361707; ENSG00000172465 [Q15170-2]
ENST00000372625; ENSP00000361708; ENSG00000172465 [Q15170-2]
ENST00000372626; ENSP00000361709; ENSG00000172465 [Q15170-2]
GeneIDi9338
KEGGihsa:9338
UCSCiuc004eks.4 human [Q15170-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiTCAL1_HUMAN
AccessioniPrimary (citable) accession number: Q15170
Secondary accession number(s): Q9UJQ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 30, 2006
Last sequence update: May 30, 2006
Last modified: June 20, 2018
This is version 132 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

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