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Q15165

- PON2_HUMAN

UniProt

Q15165 - PON2_HUMAN

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Protein

Serum paraoxonase/arylesterase 2

Gene
PON2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.2 Publications

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.1 Publication
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.1 Publication

Cofactori

Binds 2 calcium ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi53 – 531Calcium 1; catalytic By similarity
Metal bindingi54 – 541Calcium 2 By similarity
Active sitei114 – 1141Proton acceptor By similarity
Metal bindingi116 – 1161Calcium 2; via carbonyl oxygen By similarity
Metal bindingi167 – 1671Calcium 1; catalytic By similarity
Metal bindingi168 – 1681Calcium 2 By similarity
Metal bindingi223 – 2231Calcium 1; catalytic By similarity
Metal bindingi268 – 2681Calcium 1; catalytic By similarity
Metal bindingi269 – 2691Calcium 1; catalytic By similarity

GO - Molecular functioni

  1. arylesterase activity Source: ProtInc
  2. identical protein binding Source: BHF-UCL
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. aromatic compound catabolic process Source: BHF-UCL
  2. response to oxidative stress Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/arylesterase 2 (EC:3.1.1.2, EC:3.1.1.81)
Short name:
PON 2
Alternative name(s):
Aromatic esterase 2
Short name:
A-esterase 2
Serum aryldialkylphosphatase 2
Gene namesi
Name:PON2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:9205. PON2.

Subcellular locationi

Membrane; Peripheral membrane protein 1 Publication

GO - Cellular componenti

  1. extracellular region Source: InterPro
  2. lysosome Source: Ensembl
  3. mitochondrion Source: Ensembl
  4. nucleus Source: Ensembl
  5. plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

Orphaneti803. Amyotrophic lateral sclerosis.
PharmGKBiPA33530.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Serum paraoxonase/arylesterase 2PRO_0000223287Add
BLAST
Signal peptidei1 – ?Not cleaved By similarity

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi42 ↔ 352 By similarity
Glycosylationi254 – 2541N-linked (GlcNAc...)1 Publication
Glycosylationi269 – 2691N-linked (GlcNAc...) Reviewed prediction
Glycosylationi323 – 3231N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

The signal sequence is not cleaved By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ15165.
PaxDbiQ15165.
PRIDEiQ15165.

PTM databases

PhosphoSiteiQ15165.

Expressioni

Tissue specificityi

Widely expressed with highest expression in liver, lung, placenta, testis and heart.1 Publication

Gene expression databases

ArrayExpressiQ15165.
BgeeiQ15165.
CleanExiHS_PON2.
GenevestigatoriQ15165.

Organism-specific databases

HPAiCAB025430.
HPA029193.

Interactioni

Subunit structurei

Homotrimer.1 Publication

Protein-protein interaction databases

BioGridi111441. 13 interactions.
IntActiQ15165. 3 interactions.
STRINGi9606.ENSP00000222572.

Structurei

3D structure databases

ProteinModelPortaliQ15165.
SMRiQ15165. Positions 23-354.

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG68009.
HOVERGENiHBG003604.
KOiK01045.
PhylomeDBiQ15165.
TreeFamiTF322436.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 2 (identifier: Q15165-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA    50
GSEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KEEKPRAREL 100
RISRGFDLAS FNPHGISTFI DNDDTVYLFV VNHPEFKNTV EIFKFEEAEN 150
SLLHLKTVKH ELLPSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH 200
WANVVYYSPN EVKVVAEGFD SANGINISPD DKYIYVADIL AHEIHVLEKH 250
TNMNLTQLKV LELDTLVDNL SIDPSSGDIW VGCHPNGQKL FVYDPNNPPS 300
SEVLRIQNIL CEKPTVTTVY ANNGSVLQGS SVASVYDGKL LIGTLYHRAL 350
YCEL 354
Length:354
Mass (Da):39,397
Last modified:March 8, 2011 - v3
Checksum:i05CEDC84D5E7EC2A
GO
Isoform 1 (identifier: Q15165-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGRLVAVGLLGIALAL → MGAWVGCGLAGDRAGF

Show »
Length:354
Mass (Da):39,398
Checksum:iAAA1980D3850889D
GO
Isoform 3 (identifier: Q15165-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-134: Missing.

Show »
Length:342
Mass (Da):37,996
Checksum:i71F47B3E08154500
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti148 – 1481A → G Associated with elevated mean fasting plasma glucose level. 3 Publications
Corresponds to variant rs12026 [ dbSNP | Ensembl ].
VAR_006045
Natural varianti172 – 1721V → L.1 Publication
Corresponds to variant rs17876152 [ dbSNP | Ensembl ].
VAR_020786
Natural varianti311 – 3111C → S Associated with increased risk of coronary heart disease; CHD. 7 Publications
Corresponds to variant rs7493 [ dbSNP | Ensembl ].
VAR_006046

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1616MGRLV…IALAL → MGAWVGCGLAGDRAGF in isoform 1. VSP_004533Add
BLAST
Alternative sequencei123 – 13412Missing in isoform 3. VSP_040715Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti49 – 502EA → VW in AAC27945. 1 Publication
Sequence conflicti53 – 531E → D in BAG37646. 1 Publication
Sequence conflicti63 – 631A → V in BAG58797. 1 Publication
Sequence conflicti194 – 1941E → G in AAC41995. 1 Publication
Sequence conflicti282 – 2821G → V in AAC27944. 1 Publication
Sequence conflicti282 – 2821G → V in BAD89420. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L48513 mRNA. Translation: AAC41995.1.
AF001601 mRNA. Translation: AAC27944.1.
AF001602 mRNA. Translation: AAC27945.1.
AF001603 Genomic DNA. Translation: AAC27946.1.
AB102891 mRNA. Translation: BAD89420.1.
AK291103 mRNA. Translation: BAF83792.1.
AK296029 mRNA. Translation: BAG58797.1.
AK315209 mRNA. Translation: BAG37646.1.
AY210982 Genomic DNA. Translation: AAO18083.1.
AC005021 Genomic DNA. Translation: AAC62431.1.
CH236949 Genomic DNA. Translation: EAL24131.1.
BC040010 mRNA. Translation: AAH40010.1.
CCDSiCCDS47644.1. [Q15165-3]
CCDS5640.1. [Q15165-2]
RefSeqiNP_000296.2. NM_000305.2.
UniGeneiHs.744912.

Genome annotation databases

EnsembliENST00000222572; ENSP00000222572; ENSG00000105854.
ENST00000446142; ENSP00000405211; ENSG00000105854.
GeneIDi5445.
KEGGihsa:5445.

Polymorphism databases

DMDMi325511384.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L48513 mRNA. Translation: AAC41995.1 .
AF001601 mRNA. Translation: AAC27944.1 .
AF001602 mRNA. Translation: AAC27945.1 .
AF001603 Genomic DNA. Translation: AAC27946.1 .
AB102891 mRNA. Translation: BAD89420.1 .
AK291103 mRNA. Translation: BAF83792.1 .
AK296029 mRNA. Translation: BAG58797.1 .
AK315209 mRNA. Translation: BAG37646.1 .
AY210982 Genomic DNA. Translation: AAO18083.1 .
AC005021 Genomic DNA. Translation: AAC62431.1 .
CH236949 Genomic DNA. Translation: EAL24131.1 .
BC040010 mRNA. Translation: AAH40010.1 .
CCDSi CCDS47644.1. [Q15165-3 ]
CCDS5640.1. [Q15165-2 ]
RefSeqi NP_000296.2. NM_000305.2.
UniGenei Hs.744912.

3D structure databases

ProteinModelPortali Q15165.
SMRi Q15165. Positions 23-354.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111441. 13 interactions.
IntActi Q15165. 3 interactions.
STRINGi 9606.ENSP00000222572.

PTM databases

PhosphoSitei Q15165.

Polymorphism databases

DMDMi 325511384.

Proteomic databases

MaxQBi Q15165.
PaxDbi Q15165.
PRIDEi Q15165.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222572 ; ENSP00000222572 ; ENSG00000105854 .
ENST00000446142 ; ENSP00000405211 ; ENSG00000105854 .
GeneIDi 5445.
KEGGi hsa:5445.

Organism-specific databases

CTDi 5445.
GeneCardsi GC07M095034.
HGNCi HGNC:9205. PON2.
HPAi CAB025430.
HPA029193.
MIMi 602447. gene.
neXtProti NX_Q15165.
Orphaneti 803. Amyotrophic lateral sclerosis.
PharmGKBi PA33530.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG68009.
HOVERGENi HBG003604.
KOi K01045.
PhylomeDBi Q15165.
TreeFami TF322436.

Miscellaneous databases

GeneWikii PON2.
GenomeRNAii 5445.
NextBioi 21073.
PROi Q15165.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15165.
Bgeei Q15165.
CleanExi HS_PON2.
Genevestigatori Q15165.

Family and domain databases

Gene3Di 2.120.10.30. 1 hit.
InterProi IPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view ]
Pfami PF01731. Arylesterase. 1 hit.
[Graphical view ]
PRINTSi PR01785. PARAOXONASE.
PR01787. PARAOXONASE2.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family."
    Primo-Parmo S.L., Sorenson R.C., Teiber J., La Du B.N.
    Genomics 33:498-507(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-311.
    Tissue: Liver.
  2. "Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence."
    Mochizuki H., Scherer S.W., Xi T., Nickle D.C., Majer M., Huizenga J.J., Tsui L.-C., Prochazka M.
    Gene 213:149-157(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-67, ALTERNATIVE SPLICING, VARIANTS GLY-148 AND SER-311.
  3. "Paraoxonase mRNA,nirs splice variant1."
    Sameshima E., Tabata Y., Hayashi A., Iida K., Mitsuyama M., Kanai S., Furuya T., Saito T.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT SER-311.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT SER-311.
    Tissue: Subthalamic nucleus and Testis.
  5. SeattleSNPs variation discovery resource
    Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-148; LEU-172 AND SER-311.
  6. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-311.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Skin.
  9. "Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein."
    Ng C.J., Wadleigh D.J., Gangopadhyay A., Hama S., Grijalva V.R., Navab M., Fogelman A.M., Reddy S.T.
    J. Biol. Chem. 276:44444-44449(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
  10. "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities."
    Draganov D.I., Teiber J.F., Speelman A., Osawa Y., Sunahara R., La Du B.N.
    J. Lipid Res. 46:1239-1247(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBUNIT.
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-254.
    Tissue: Liver.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus."
    Hegele R.A., Connelly P.W., Scherer S.W., Hanley A.J.G., Harris S.B., Tsui L.-C., Zinman B.
    J. Clin. Endocrinol. Metab. 82:3373-3377(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT GLY-148.
  14. "DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease."
    Sanghera D.K., Aston C.E., Saha N., Kamboh M.I.
    Am. J. Hum. Genet. 62:36-44(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-311.

Entry informationi

Entry nameiPON2_HUMAN
AccessioniPrimary (citable) accession number: Q15165
Secondary accession number(s): A4D1H7
, B2RCP9, B4DJD5, O15114, O15115, O75856, Q5FBX7, Q86YL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 8, 2011
Last modified: July 9, 2014
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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