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Q15165

- PON2_HUMAN

UniProt

Q15165 - PON2_HUMAN

Protein

Serum paraoxonase/arylesterase 2

Gene

PON2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 130 (01 Oct 2014)
      Sequence version 3 (08 Mar 2011)
      Previous versions | rss
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    Functioni

    Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.2 Publications

    Catalytic activityi

    A phenyl acetate + H2O = a phenol + acetate.1 Publication
    An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.1 Publication

    Cofactori

    Binds 2 calcium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi53 – 531Calcium 1; catalyticBy similarity
    Metal bindingi54 – 541Calcium 2By similarity
    Active sitei114 – 1141Proton acceptorBy similarity
    Metal bindingi116 – 1161Calcium 2; via carbonyl oxygenBy similarity
    Metal bindingi167 – 1671Calcium 1; catalyticBy similarity
    Metal bindingi168 – 1681Calcium 2By similarity
    Metal bindingi223 – 2231Calcium 1; catalyticBy similarity
    Metal bindingi268 – 2681Calcium 1; catalyticBy similarity
    Metal bindingi269 – 2691Calcium 1; catalyticBy similarity

    GO - Molecular functioni

    1. arylesterase activity Source: ProtInc
    2. identical protein binding Source: BHF-UCL
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. aromatic compound catabolic process Source: BHF-UCL
    2. response to oxidative stress Source: Ensembl

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Serum paraoxonase/arylesterase 2 (EC:3.1.1.2, EC:3.1.1.81)
    Short name:
    PON 2
    Alternative name(s):
    Aromatic esterase 2
    Short name:
    A-esterase 2
    Serum aryldialkylphosphatase 2
    Gene namesi
    Name:PON2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:9205. PON2.

    Subcellular locationi

    Membrane 1 Publication; Peripheral membrane protein 1 Publication

    GO - Cellular componenti

    1. extracellular region Source: InterPro
    2. lysosome Source: Ensembl
    3. mitochondrion Source: Ensembl
    4. nucleus Source: Ensembl
    5. plasma membrane Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti803. Amyotrophic lateral sclerosis.
    PharmGKBiPA33530.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Serum paraoxonase/arylesterase 2PRO_0000223287Add
    BLAST
    Signal peptidei1 – ?Not cleavedBy similarity

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi42 ↔ 352By similarity
    Glycosylationi254 – 2541N-linked (GlcNAc...)1 Publication
    Glycosylationi269 – 2691N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi323 – 3231N-linked (GlcNAc...)Sequence Analysis

    Post-translational modificationi

    The signal sequence is not cleaved.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    MaxQBiQ15165.
    PaxDbiQ15165.
    PRIDEiQ15165.

    PTM databases

    PhosphoSiteiQ15165.

    Expressioni

    Tissue specificityi

    Widely expressed with highest expression in liver, lung, placenta, testis and heart.1 Publication

    Gene expression databases

    ArrayExpressiQ15165.
    BgeeiQ15165.
    CleanExiHS_PON2.
    GenevestigatoriQ15165.

    Organism-specific databases

    HPAiCAB025430.
    HPA029193.

    Interactioni

    Subunit structurei

    Homotrimer.1 Publication

    Protein-protein interaction databases

    BioGridi111441. 13 interactions.
    IntActiQ15165. 3 interactions.
    STRINGi9606.ENSP00000222572.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15165.
    SMRiQ15165. Positions 23-354.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the paraoxonase family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG68009.
    HOVERGENiHBG003604.
    KOiK01045.
    PhylomeDBiQ15165.
    TreeFamiTF322436.

    Family and domain databases

    Gene3Di2.120.10.30. 1 hit.
    InterProiIPR011042. 6-blade_b-propeller_TolB-like.
    IPR002640. Arylesterase.
    IPR008364. Paraoxonase2.
    [Graphical view]
    PfamiPF01731. Arylesterase. 1 hit.
    [Graphical view]
    PRINTSiPR01785. PARAOXONASE.
    PR01787. PARAOXONASE2.

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 2 (identifier: Q15165-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA    50
    GSEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KEEKPRAREL 100
    RISRGFDLAS FNPHGISTFI DNDDTVYLFV VNHPEFKNTV EIFKFEEAEN 150
    SLLHLKTVKH ELLPSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH 200
    WANVVYYSPN EVKVVAEGFD SANGINISPD DKYIYVADIL AHEIHVLEKH 250
    TNMNLTQLKV LELDTLVDNL SIDPSSGDIW VGCHPNGQKL FVYDPNNPPS 300
    SEVLRIQNIL CEKPTVTTVY ANNGSVLQGS SVASVYDGKL LIGTLYHRAL 350
    YCEL 354
    Length:354
    Mass (Da):39,397
    Last modified:March 8, 2011 - v3
    Checksum:i05CEDC84D5E7EC2A
    GO
    Isoform 1 (identifier: Q15165-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-16: MGRLVAVGLLGIALAL → MGAWVGCGLAGDRAGF

    Show »
    Length:354
    Mass (Da):39,398
    Checksum:iAAA1980D3850889D
    GO
    Isoform 3 (identifier: Q15165-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         123-134: Missing.

    Show »
    Length:342
    Mass (Da):37,996
    Checksum:i71F47B3E08154500
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti49 – 502EA → VW in AAC27945. (PubMed:9714608)Curated
    Sequence conflicti53 – 531E → D in BAG37646. (PubMed:14702039)Curated
    Sequence conflicti63 – 631A → V in BAG58797. (PubMed:14702039)Curated
    Sequence conflicti194 – 1941E → G in AAC41995. (PubMed:8661009)Curated
    Sequence conflicti282 – 2821G → V in AAC27944. (PubMed:9714608)Curated
    Sequence conflicti282 – 2821G → V in BAD89420. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti148 – 1481A → G Associated with elevated mean fasting plasma glucose level. 3 Publications
    Corresponds to variant rs12026 [ dbSNP | Ensembl ].
    VAR_006045
    Natural varianti172 – 1721V → L.1 Publication
    Corresponds to variant rs17876152 [ dbSNP | Ensembl ].
    VAR_020786
    Natural varianti311 – 3111C → S Associated with increased risk of coronary heart disease; CHD. 7 Publications
    Corresponds to variant rs7493 [ dbSNP | Ensembl ].
    VAR_006046

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1616MGRLV…IALAL → MGAWVGCGLAGDRAGF in isoform 1. 1 PublicationVSP_004533Add
    BLAST
    Alternative sequencei123 – 13412Missing in isoform 3. 2 PublicationsVSP_040715Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L48513 mRNA. Translation: AAC41995.1.
    AF001601 mRNA. Translation: AAC27944.1.
    AF001602 mRNA. Translation: AAC27945.1.
    AF001603 Genomic DNA. Translation: AAC27946.1.
    AB102891 mRNA. Translation: BAD89420.1.
    AK291103 mRNA. Translation: BAF83792.1.
    AK296029 mRNA. Translation: BAG58797.1.
    AK315209 mRNA. Translation: BAG37646.1.
    AY210982 Genomic DNA. Translation: AAO18083.1.
    AC005021 Genomic DNA. Translation: AAC62431.1.
    CH236949 Genomic DNA. Translation: EAL24131.1.
    BC040010 mRNA. Translation: AAH40010.1.
    CCDSiCCDS47644.1. [Q15165-3]
    CCDS5640.1. [Q15165-2]
    RefSeqiNP_000296.2. NM_000305.2.
    UniGeneiHs.744912.

    Genome annotation databases

    EnsembliENST00000222572; ENSP00000222572; ENSG00000105854.
    ENST00000446142; ENSP00000405211; ENSG00000105854.
    GeneIDi5445.
    KEGGihsa:5445.

    Polymorphism databases

    DMDMi325511384.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    SeattleSNPs
    SHMPD

    The Singapore human mutation and polymorphism database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L48513 mRNA. Translation: AAC41995.1 .
    AF001601 mRNA. Translation: AAC27944.1 .
    AF001602 mRNA. Translation: AAC27945.1 .
    AF001603 Genomic DNA. Translation: AAC27946.1 .
    AB102891 mRNA. Translation: BAD89420.1 .
    AK291103 mRNA. Translation: BAF83792.1 .
    AK296029 mRNA. Translation: BAG58797.1 .
    AK315209 mRNA. Translation: BAG37646.1 .
    AY210982 Genomic DNA. Translation: AAO18083.1 .
    AC005021 Genomic DNA. Translation: AAC62431.1 .
    CH236949 Genomic DNA. Translation: EAL24131.1 .
    BC040010 mRNA. Translation: AAH40010.1 .
    CCDSi CCDS47644.1. [Q15165-3 ]
    CCDS5640.1. [Q15165-2 ]
    RefSeqi NP_000296.2. NM_000305.2.
    UniGenei Hs.744912.

    3D structure databases

    ProteinModelPortali Q15165.
    SMRi Q15165. Positions 23-354.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111441. 13 interactions.
    IntActi Q15165. 3 interactions.
    STRINGi 9606.ENSP00000222572.

    PTM databases

    PhosphoSitei Q15165.

    Polymorphism databases

    DMDMi 325511384.

    Proteomic databases

    MaxQBi Q15165.
    PaxDbi Q15165.
    PRIDEi Q15165.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222572 ; ENSP00000222572 ; ENSG00000105854 .
    ENST00000446142 ; ENSP00000405211 ; ENSG00000105854 .
    GeneIDi 5445.
    KEGGi hsa:5445.

    Organism-specific databases

    CTDi 5445.
    GeneCardsi GC07M095034.
    HGNCi HGNC:9205. PON2.
    HPAi CAB025430.
    HPA029193.
    MIMi 602447. gene.
    neXtProti NX_Q15165.
    Orphaneti 803. Amyotrophic lateral sclerosis.
    PharmGKBi PA33530.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG68009.
    HOVERGENi HBG003604.
    KOi K01045.
    PhylomeDBi Q15165.
    TreeFami TF322436.

    Miscellaneous databases

    GeneWikii PON2.
    GenomeRNAii 5445.
    NextBioi 21073.
    PROi Q15165.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q15165.
    Bgeei Q15165.
    CleanExi HS_PON2.
    Genevestigatori Q15165.

    Family and domain databases

    Gene3Di 2.120.10.30. 1 hit.
    InterProi IPR011042. 6-blade_b-propeller_TolB-like.
    IPR002640. Arylesterase.
    IPR008364. Paraoxonase2.
    [Graphical view ]
    Pfami PF01731. Arylesterase. 1 hit.
    [Graphical view ]
    PRINTSi PR01785. PARAOXONASE.
    PR01787. PARAOXONASE2.
    ProtoNeti Search...

    Publicationsi

    1. "The human serum paraoxonase/arylesterase gene (PON1) is one member of a multigene family."
      Primo-Parmo S.L., Sorenson R.C., Teiber J., La Du B.N.
      Genomics 33:498-507(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT SER-311.
      Tissue: Liver.
    2. "Human PON2 gene at 7q21.3: cloning, multiple mRNA forms, and missense polymorphisms in the coding sequence."
      Mochizuki H., Scherer S.W., Xi T., Nickle D.C., Majer M., Huizenga J.J., Tsui L.-C., Prochazka M.
      Gene 213:149-157(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 50-67, ALTERNATIVE SPLICING, VARIANTS GLY-148 AND SER-311.
    3. "Paraoxonase mRNA,nirs splice variant1."
      Sameshima E., Tabata Y., Hayashi A., Iida K., Mitsuyama M., Kanai S., Furuya T., Saito T.
      Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3), VARIANT SER-311.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3), VARIANT SER-311.
      Tissue: Subthalamic nucleus and Testis.
    5. SeattleSNPs variation discovery resource
      Submitted (JAN-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS GLY-148; LEU-172 AND SER-311.
    6. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT SER-311.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Skin.
    9. "Paraoxonase-2 is a ubiquitously expressed protein with antioxidant properties and is capable of preventing cell-mediated oxidative modification of low density lipoprotein."
      Ng C.J., Wadleigh D.J., Gangopadhyay A., Hama S., Grijalva V.R., Navab M., Fogelman A.M., Reddy S.T.
      J. Biol. Chem. 276:44444-44449(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    10. "Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities."
      Draganov D.I., Teiber J.F., Speelman A., Osawa Y., Sunahara R., La Du B.N.
      J. Lipid Res. 46:1239-1247(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBUNIT.
    11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-254.
      Tissue: Liver.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "Paraoxonase-2 gene (PON2) G148 variant associated with elevated fasting plasma glucose in noninsulin-dependent diabetes mellitus."
      Hegele R.A., Connelly P.W., Scherer S.W., Hanley A.J.G., Harris S.B., Tsui L.-C., Zinman B.
      J. Clin. Endocrinol. Metab. 82:3373-3377(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT GLY-148.
    14. "DNA polymorphisms in two paraoxonase genes (PON1 and PON2) are associated with the risk of coronary heart disease."
      Sanghera D.K., Aston C.E., Saha N., Kamboh M.I.
      Am. J. Hum. Genet. 62:36-44(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT SER-311.

    Entry informationi

    Entry nameiPON2_HUMAN
    AccessioniPrimary (citable) accession number: Q15165
    Secondary accession number(s): A4D1H7
    , B2RCP9, B4DJD5, O15114, O15115, O75856, Q5FBX7, Q86YL0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: March 8, 2011
    Last modified: October 1, 2014
    This is version 130 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

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