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Protein

Serum paraoxonase/arylesterase 2

Gene

PON2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.2 Publications

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.1 Publication
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium 1; catalyticBy similarity1
Metal bindingi54Calcium 2By similarity1
Active sitei114Proton acceptorBy similarity1
Metal bindingi116Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi167Calcium 1; catalyticBy similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi223Calcium 1; catalyticBy similarity1
Metal bindingi268Calcium 1; catalyticBy similarity1
Metal bindingi269Calcium 1; catalyticBy similarity1

GO - Molecular functioni

  • acyl-L-homoserine-lactone lactonohydrolase activity Source: UniProtKB-EC
  • arylesterase activity Source: ProtInc
  • identical protein binding Source: BHF-UCL
  • metal ion binding Source: UniProtKB-KW

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

BioCyciZFISH:HS02820-MONOMER.
BRENDAi3.1.1.2. 2681.
3.1.1.25. 2681.
ReactomeiR-HSA-2142688. Synthesis of 5-eicosatetraenoic acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/arylesterase 2 (EC:3.1.1.2, EC:3.1.1.81)
Short name:
PON 2
Alternative name(s):
Aromatic esterase 2
Short name:
A-esterase 2
Serum aryldialkylphosphatase 2
Gene namesi
Name:PON2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:9205. PON2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: InterPro
  • lysosome Source: Ensembl
  • mitochondrion Source: Ensembl
  • nucleus Source: Ensembl
  • plasma membrane Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5445.
MalaCardsiPON2.
Orphaneti803. Amyotrophic lateral sclerosis.
PharmGKBiPA33530.

Polymorphism and mutation databases

BioMutaiPON2.
DMDMi325511384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232871 – 354Serum paraoxonase/arylesterase 2Add BLAST354
Signal peptidei1 – ?Not cleavedBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 352By similarity
Glycosylationi254N-linked (GlcNAc...)1 Publication1
Glycosylationi269N-linked (GlcNAc...)Sequence analysis1
Glycosylationi323N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15165.
PaxDbiQ15165.
PeptideAtlasiQ15165.
PRIDEiQ15165.

PTM databases

iPTMnetiQ15165.
PhosphoSitePlusiQ15165.
SwissPalmiQ15165.

Expressioni

Tissue specificityi

Widely expressed with highest expression in liver, lung, placenta, testis and heart.1 Publication

Gene expression databases

BgeeiENSG00000105854.
CleanExiHS_PON2.
ExpressionAtlasiQ15165. baseline and differential.
GenevisibleiQ15165. HS.

Organism-specific databases

HPAiCAB025430.
HPA029193.

Interactioni

Subunit structurei

Homotrimer.1 Publication

GO - Molecular functioni

  • identical protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi111441. 87 interactors.
DIPiDIP-61136N.
IntActiQ15165. 10 interactors.
STRINGi9606.ENSP00000222572.

Structurei

3D structure databases

ProteinModelPortaliQ15165.
SMRiQ15165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
HOVERGENiHBG003604.
InParanoidiQ15165.
KOiK01045.
OrthoDBiEOG091G0AV9.
PhylomeDBiQ15165.
TreeFamiTF322436.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q15165-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA
60 70 80 90 100
GSEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KEEKPRAREL
110 120 130 140 150
RISRGFDLAS FNPHGISTFI DNDDTVYLFV VNHPEFKNTV EIFKFEEAEN
160 170 180 190 200
SLLHLKTVKH ELLPSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH
210 220 230 240 250
WANVVYYSPN EVKVVAEGFD SANGINISPD DKYIYVADIL AHEIHVLEKH
260 270 280 290 300
TNMNLTQLKV LELDTLVDNL SIDPSSGDIW VGCHPNGQKL FVYDPNNPPS
310 320 330 340 350
SEVLRIQNIL CEKPTVTTVY ANNGSVLQGS SVASVYDGKL LIGTLYHRAL

YCEL
Length:354
Mass (Da):39,397
Last modified:March 8, 2011 - v3
Checksum:i05CEDC84D5E7EC2A
GO
Isoform 1 (identifier: Q15165-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGRLVAVGLLGIALAL → MGAWVGCGLAGDRAGF

Show »
Length:354
Mass (Da):39,398
Checksum:iAAA1980D3850889D
GO
Isoform 3 (identifier: Q15165-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-134: Missing.

Show »
Length:342
Mass (Da):37,996
Checksum:i71F47B3E08154500
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 50EA → VW in AAC27945 (PubMed:9714608).Curated2
Sequence conflicti53E → D in BAG37646 (PubMed:14702039).Curated1
Sequence conflicti63A → V in BAG58797 (PubMed:14702039).Curated1
Sequence conflicti194E → G in AAC41995 (PubMed:8661009).Curated1
Sequence conflicti282G → V in AAC27944 (PubMed:9714608).Curated1
Sequence conflicti282G → V in BAD89420 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_006045148A → G Associated with elevated mean fasting plasma glucose level. 3 PublicationsCorresponds to variant rs12026dbSNPEnsembl.1
Natural variantiVAR_020786172V → L.1 PublicationCorresponds to variant rs17876152dbSNPEnsembl.1
Natural variantiVAR_006046311C → S Polymorphism; associated with increased risk of coronary heart disease. 7 PublicationsCorresponds to variant rs7493dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0045331 – 16MGRLV…IALAL → MGAWVGCGLAGDRAGF in isoform 1. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_040715123 – 134Missing in isoform 3. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L48513 mRNA. Translation: AAC41995.1.
AF001601 mRNA. Translation: AAC27944.1.
AF001602 mRNA. Translation: AAC27945.1.
AF001603 Genomic DNA. Translation: AAC27946.1.
AB102891 mRNA. Translation: BAD89420.1.
AK291103 mRNA. Translation: BAF83792.1.
AK296029 mRNA. Translation: BAG58797.1.
AK315209 mRNA. Translation: BAG37646.1.
AY210982 Genomic DNA. Translation: AAO18083.1.
AC005021 Genomic DNA. Translation: AAC62431.1.
CH236949 Genomic DNA. Translation: EAL24131.1.
BC040010 mRNA. Translation: AAH40010.1.
CCDSiCCDS47644.1. [Q15165-3]
CCDS5640.1. [Q15165-2]
RefSeqiNP_000296.2. NM_000305.2.
UniGeneiHs.514420.
Hs.744912.

Genome annotation databases

EnsembliENST00000222572; ENSP00000222572; ENSG00000105854.
ENST00000446142; ENSP00000405211; ENSG00000105854.
GeneIDi5445.
KEGGihsa:5445.
UCSCiuc003unv.4. human. [Q15165-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs
SHMPD

The Singapore human mutation and polymorphism database

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L48513 mRNA. Translation: AAC41995.1.
AF001601 mRNA. Translation: AAC27944.1.
AF001602 mRNA. Translation: AAC27945.1.
AF001603 Genomic DNA. Translation: AAC27946.1.
AB102891 mRNA. Translation: BAD89420.1.
AK291103 mRNA. Translation: BAF83792.1.
AK296029 mRNA. Translation: BAG58797.1.
AK315209 mRNA. Translation: BAG37646.1.
AY210982 Genomic DNA. Translation: AAO18083.1.
AC005021 Genomic DNA. Translation: AAC62431.1.
CH236949 Genomic DNA. Translation: EAL24131.1.
BC040010 mRNA. Translation: AAH40010.1.
CCDSiCCDS47644.1. [Q15165-3]
CCDS5640.1. [Q15165-2]
RefSeqiNP_000296.2. NM_000305.2.
UniGeneiHs.514420.
Hs.744912.

3D structure databases

ProteinModelPortaliQ15165.
SMRiQ15165.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111441. 87 interactors.
DIPiDIP-61136N.
IntActiQ15165. 10 interactors.
STRINGi9606.ENSP00000222572.

PTM databases

iPTMnetiQ15165.
PhosphoSitePlusiQ15165.
SwissPalmiQ15165.

Polymorphism and mutation databases

BioMutaiPON2.
DMDMi325511384.

Proteomic databases

EPDiQ15165.
PaxDbiQ15165.
PeptideAtlasiQ15165.
PRIDEiQ15165.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222572; ENSP00000222572; ENSG00000105854.
ENST00000446142; ENSP00000405211; ENSG00000105854.
GeneIDi5445.
KEGGihsa:5445.
UCSCiuc003unv.4. human. [Q15165-2]

Organism-specific databases

CTDi5445.
DisGeNETi5445.
GeneCardsiPON2.
HGNCiHGNC:9205. PON2.
HPAiCAB025430.
HPA029193.
MalaCardsiPON2.
MIMi602447. gene.
neXtProtiNX_Q15165.
Orphaneti803. Amyotrophic lateral sclerosis.
PharmGKBiPA33530.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
HOVERGENiHBG003604.
InParanoidiQ15165.
KOiK01045.
OrthoDBiEOG091G0AV9.
PhylomeDBiQ15165.
TreeFamiTF322436.

Enzyme and pathway databases

BioCyciZFISH:HS02820-MONOMER.
BRENDAi3.1.1.2. 2681.
3.1.1.25. 2681.
ReactomeiR-HSA-2142688. Synthesis of 5-eicosatetraenoic acids.

Miscellaneous databases

ChiTaRSiPON2. human.
GeneWikiiPON2.
GenomeRNAii5445.
PROiQ15165.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105854.
CleanExiHS_PON2.
ExpressionAtlasiQ15165. baseline and differential.
GenevisibleiQ15165. HS.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiIPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
[Graphical view]
PfamiPF01731. Arylesterase. 1 hit.
[Graphical view]
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.
ProtoNetiSearch...

Entry informationi

Entry nameiPON2_HUMAN
AccessioniPrimary (citable) accession number: Q15165
Secondary accession number(s): A4D1H7
, B2RCP9, B4DJD5, O15114, O15115, O75856, Q5FBX7, Q86YL0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 8, 2011
Last modified: November 30, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.