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Protein

Serum paraoxonase/arylesterase 2

Gene

PON2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Capable of hydrolyzing lactones and a number of aromatic carboxylic acid esters. Has antioxidant activity. Is not associated with high density lipoprotein. Prevents LDL lipid peroxidation, reverses the oxidation of mildly oxidized LDL, and inhibits the ability of MM-LDL to induce monocyte chemotaxis.2 Publications

Catalytic activityi

A phenyl acetate + H2O = a phenol + acetate.1 Publication
An N-acyl-L-homoserine lactone + H2O = an N-acyl-L-homoserine.1 Publication

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi53Calcium 1; catalyticBy similarity1
Metal bindingi54Calcium 2By similarity1
Active sitei114Proton acceptorBy similarity1
Metal bindingi116Calcium 2; via carbonyl oxygenBy similarity1
Metal bindingi167Calcium 1; catalyticBy similarity1
Metal bindingi168Calcium 2By similarity1
Metal bindingi223Calcium 1; catalyticBy similarity1
Metal bindingi268Calcium 1; catalyticBy similarity1
Metal bindingi269Calcium 1; catalyticBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
LigandCalcium, Metal-binding

Enzyme and pathway databases

BRENDAi3.1.1.2. 2681.
3.1.1.25. 2681.
ReactomeiR-HSA-2142688. Synthesis of 5-eicosatetraenoic acids.

Names & Taxonomyi

Protein namesi
Recommended name:
Serum paraoxonase/arylesterase 2 (EC:3.1.1.2, EC:3.1.1.81)
Short name:
PON 2
Alternative name(s):
Aromatic esterase 2
Short name:
A-esterase 2
Serum aryldialkylphosphatase 2
Gene namesi
Name:PON2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000105854.12.
HGNCiHGNC:9205. PON2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi5445.
MalaCardsiPON2.
Orphaneti803. Amyotrophic lateral sclerosis.
PharmGKBiPA33530.

Polymorphism and mutation databases

BioMutaiPON2.
DMDMi325511384.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002232871 – 354Serum paraoxonase/arylesterase 2Add BLAST354
Signal peptidei1 – ?Not cleavedBy similarity

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 352By similarity
Glycosylationi254N-linked (GlcNAc...) asparagine1 Publication1
Glycosylationi269N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi323N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

The signal sequence is not cleaved.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiQ15165.
PaxDbiQ15165.
PeptideAtlasiQ15165.
PRIDEiQ15165.

PTM databases

iPTMnetiQ15165.
PhosphoSitePlusiQ15165.
SwissPalmiQ15165.

Expressioni

Tissue specificityi

Widely expressed with highest expression in liver, lung, placenta, testis and heart.1 Publication

Gene expression databases

BgeeiENSG00000105854.
CleanExiHS_PON2.
ExpressionAtlasiQ15165. baseline and differential.
GenevisibleiQ15165. HS.

Organism-specific databases

HPAiCAB025430.
HPA029193.

Interactioni

Subunit structurei

Homotrimer.1 Publication

GO - Molecular functioni

  • identical protein binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi111441. 92 interactors.
DIPiDIP-61136N.
IntActiQ15165. 12 interactors.
STRINGi9606.ENSP00000222572.

Structurei

3D structure databases

ProteinModelPortaliQ15165.
SMRiQ15165.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the paraoxonase family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHDV. Eukaryota.
ENOG4111QK7. LUCA.
HOVERGENiHBG003604.
InParanoidiQ15165.
KOiK01045.
OrthoDBiEOG091G0AV9.
PhylomeDBiQ15165.
TreeFamiTF322436.

Family and domain databases

Gene3Di2.120.10.30. 1 hit.
InterProiView protein in InterPro
IPR011042. 6-blade_b-propeller_TolB-like.
IPR002640. Arylesterase.
IPR008364. Paraoxonase2.
PfamiView protein in Pfam
PF01731. Arylesterase. 1 hit.
PRINTSiPR01785. PARAOXONASE.
PR01787. PARAOXONASE2.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 2 (identifier: Q15165-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGRLVAVGLL GIALALLGER LLALRNRLKA SREVESVDLP HCHLIKGIEA
60 70 80 90 100
GSEDIDILPN GLAFFSVGLK FPGLHSFAPD KPGGILMMDL KEEKPRAREL
110 120 130 140 150
RISRGFDLAS FNPHGISTFI DNDDTVYLFV VNHPEFKNTV EIFKFEEAEN
160 170 180 190 200
SLLHLKTVKH ELLPSVNDIT AVGPAHFYAT NDHYFSDPFL KYLETYLNLH
210 220 230 240 250
WANVVYYSPN EVKVVAEGFD SANGINISPD DKYIYVADIL AHEIHVLEKH
260 270 280 290 300
TNMNLTQLKV LELDTLVDNL SIDPSSGDIW VGCHPNGQKL FVYDPNNPPS
310 320 330 340 350
SEVLRIQNIL CEKPTVTTVY ANNGSVLQGS SVASVYDGKL LIGTLYHRAL

YCEL
Length:354
Mass (Da):39,397
Last modified:March 8, 2011 - v3
Checksum:i05CEDC84D5E7EC2A
GO
Isoform 1 (identifier: Q15165-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-16: MGRLVAVGLLGIALAL → MGAWVGCGLAGDRAGF

Show »
Length:354
Mass (Da):39,398
Checksum:iAAA1980D3850889D
GO
Isoform 3 (identifier: Q15165-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     123-134: Missing.

Show »
Length:342
Mass (Da):37,996
Checksum:i71F47B3E08154500
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti49 – 50EA → VW in AAC27945 (PubMed:9714608).Curated2
Sequence conflicti53E → D in BAG37646 (PubMed:14702039).Curated1
Sequence conflicti63A → V in BAG58797 (PubMed:14702039).Curated1
Sequence conflicti194E → G in AAC41995 (PubMed:8661009).Curated1
Sequence conflicti282G → V in AAC27944 (PubMed:9714608).Curated1
Sequence conflicti282G → V in BAD89420 (Ref. 3) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_006045148A → G Associated with elevated mean fasting plasma glucose level. 3 PublicationsCorresponds to variant dbSNP:rs12026Ensembl.1
Natural variantiVAR_020786172V → L1 PublicationCorresponds to variant dbSNP:rs17876152Ensembl.1
Natural variantiVAR_006046311C → S Polymorphism; associated with increased risk of coronary heart disease. 7 PublicationsCorresponds to variant dbSNP:rs7493Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0045331 – 16MGRLV…IALAL → MGAWVGCGLAGDRAGF in isoform 1. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_040715123 – 134Missing in isoform 3. 2 PublicationsAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L48513 mRNA. Translation: AAC41995.1.
AF001601 mRNA. Translation: AAC27944.1.
AF001602 mRNA. Translation: AAC27945.1.
AF001603 Genomic DNA. Translation: AAC27946.1.
AB102891 mRNA. Translation: BAD89420.1.
AK291103 mRNA. Translation: BAF83792.1.
AK296029 mRNA. Translation: BAG58797.1.
AK315209 mRNA. Translation: BAG37646.1.
AY210982 Genomic DNA. Translation: AAO18083.1.
AC005021 Genomic DNA. Translation: AAC62431.1.
CH236949 Genomic DNA. Translation: EAL24131.1.
BC040010 mRNA. Translation: AAH40010.1.
CCDSiCCDS47644.1. [Q15165-3]
CCDS5640.1. [Q15165-2]
RefSeqiNP_000296.2. NM_000305.2.
UniGeneiHs.514420.
Hs.744912.

Genome annotation databases

EnsembliENST00000222572; ENSP00000222572; ENSG00000105854.
ENST00000446142; ENSP00000405211; ENSG00000105854.
GeneIDi5445.
KEGGihsa:5445.
UCSCiuc003unv.4. human. [Q15165-2]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPON2_HUMAN
AccessioniPrimary (citable) accession number: Q15165
Secondary accession number(s): A4D1H7
, B2RCP9, B4DJD5, O15114, O15115, O75856, Q5FBX7, Q86YL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: March 8, 2011
Last modified: October 25, 2017
This is version 159 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families