ID   Q15156_HUMAN            Unreviewed;       797 AA.
AC   Q15156;
DT   01-NOV-1996, integrated into UniProtKB/TrEMBL.
DT   01-NOV-1996, sequence version 1.
DT   24-JAN-2024, entry version 164.
DE   SubName: Full=PML-RAR protein {ECO:0000313|EMBL:AAA60126.1};
GN   Name=PML-RAR {ECO:0000313|EMBL:AAA60126.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAA60126.1};
RN   [1] {ECO:0000313|EMBL:AAA60126.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=1652368; DOI=10.1016/0092-8674(91)90112-C;
RA   Kakizuka A., Miller W.H. Jr., Umenono K., Warrell R.P. Jr., Frankel S.R.,
RA   Murty V.V., Dmitrovsky E., Evans R.M.;
RT   "Chromosomal translocation t(15;17) in human acute promyelocytic leukemia
RT   fuses RAR alpha with a novel putative transcription factor, PML.";
RL   Cell 66:663-674(1991).
CC   -!- INTERACTION:
CC       Q15156; O75530: EED; NbExp=2; IntAct=EBI-867256, EBI-923794;
CC       Q15156; Q15910: EZH2; NbExp=8; IntAct=EBI-867256, EBI-530054;
CC       Q15156; P25445: FAS; NbExp=6; IntAct=EBI-867256, EBI-494743;
CC       Q15156; Q9UIS9: MBD1; NbExp=4; IntAct=EBI-867256, EBI-867196;
CC       Q15156; Q9Y618: NCOR2; NbExp=2; IntAct=EBI-867256, EBI-80830;
CC       Q15156; Q9UPP1-2: PHF8; NbExp=6; IntAct=EBI-867256, EBI-6601215;
CC       Q15156; P17947: SPI1; NbExp=20; IntAct=EBI-867256, EBI-2293548;
CC       Q15156; Q15022: SUZ12; NbExp=6; IntAct=EBI-867256, EBI-1264675;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|RuleBase:RU004334}.
CC   -!- SIMILARITY: Belongs to the nuclear hormone receptor family. NR1
CC       subfamily. {ECO:0000256|ARBA:ARBA00008092}.
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DR   EMBL; M73779; AAA60126.1; -; mRNA.
DR   PIR; C40045; C40045.
DR   AlphaFoldDB; Q15156; -.
DR   SMR; Q15156; -.
DR   IntAct; Q15156; 10.
DR   MaxQB; Q15156; -.
DR   PeptideAtlas; Q15156; -.
DR   ChiTaRS; PRAM1; human.
DR   GO; GO:0031264; C:death-inducing signaling complex; IDA:UniProtKB.
DR   GO; GO:0005654; C:nucleoplasm; IEA:UniProt.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; NAS:UniProtKB.
DR   GO; GO:0004879; F:nuclear receptor activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:2001237; P:negative regulation of extrinsic apoptotic signaling pathway; IMP:UniProtKB.
DR   GO; GO:0048384; P:retinoic acid receptor signaling pathway; IEA:InterPro.
DR   CDD; cd19804; Bbox1_TRIM19_C-V; 1.
DR   CDD; cd19770; Bbox2_TRIM19_C-V; 1.
DR   CDD; cd06964; NR_DBD_RAR; 1.
DR   CDD; cd06937; NR_LBD_RAR; 1.
DR   CDD; cd16579; RING-HC_PML_C-V; 1.
DR   Gene3D; 3.30.160.60; Classic Zinc Finger; 1.
DR   Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR   Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR035500; NHR-like_dom_sf.
DR   InterPro; IPR047159; NR_DBD_RAR.
DR   InterPro; IPR047158; NR_LBD_RAR.
DR   InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR   InterPro; IPR001723; Nuclear_hrmn_rcpt.
DR   InterPro; IPR021978; PML-like_CC.
DR   InterPro; IPR003078; Retinoic_acid_rcpt.
DR   InterPro; IPR000315; Znf_B-box.
DR   InterPro; IPR001628; Znf_hrmn_rcpt.
DR   InterPro; IPR013088; Znf_NHR/GATA.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR24085; NUCLEAR HORMONE RECEPTOR; 1.
DR   PANTHER; PTHR24085:SF8; RETINOIC ACID RECEPTOR ALPHA; 1.
DR   Pfam; PF12126; DUF3583; 1.
DR   Pfam; PF00104; Hormone_recep; 1.
DR   Pfam; PF00643; zf-B_box; 1.
DR   Pfam; PF00105; zf-C4; 1.
DR   PRINTS; PR01292; RETNOICACIDR.
DR   PRINTS; PR00398; STRDHORMONER.
DR   PRINTS; PR00047; STROIDFINGER.
DR   SMART; SM00336; BBOX; 1.
DR   SMART; SM00430; HOLI; 1.
DR   SMART; SM00184; RING; 1.
DR   SMART; SM00399; ZnF_C4; 1.
DR   SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR   SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR   SUPFAM; SSF57850; RING/U-box; 1.
DR   PROSITE; PS51843; NR_LBD; 1.
DR   PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR   PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
DR   PROSITE; PS50119; ZF_BBOX; 2.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   1: Evidence at protein level;
KW   DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004334};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW   ECO:0000256|RuleBase:RU004334};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU004334};
KW   Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU004334};
KW   Transcription {ECO:0000256|ARBA:ARBA00023163,
KW   ECO:0000256|RuleBase:RU004334};
KW   Transcription regulation {ECO:0000256|ARBA:ARBA00023015,
KW   ECO:0000256|RuleBase:RU004334};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU004334};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00024}.
FT   DOMAIN          57..92
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   DOMAIN          124..166
FT                   /note="B box-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50119"
FT   DOMAIN          184..222
FT                   /note="B box-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50119"
FT   DOMAIN          420..495
FT                   /note="Nuclear receptor"
FT                   /evidence="ECO:0000259|PROSITE:PS51030"
FT   DOMAIN          518..752
FT                   /note="NR LBD"
FT                   /evidence="ECO:0000259|PROSITE:PS51843"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          754..797
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..42
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        782..797
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   797 AA;  89282 MW;  8C16B6E85CBDD214 CRC64;
     MEPAPARSPR PQQDPARPQE PTMPPPETPS EGRQPSPSPS PTERAPASEE EFQFLRCQQC
     QAEAKCPKLL PCLHTLCSGC LEASGMQCPI CQAPWPLGAD TPALDNVFFE SLQRRLSVYR
     QIVDAQAVCT RCKESADFWC FECEQLLCAK CFEAHQWFLK HEARPLAELR NQSVREFLDG
     TRKTNNIFCS NPNHRTPTLT SIYCRGCSKP LCCSCALLDS SHSELKCDIS AEIQQRQEEL
     DAMTQALQEQ DSAFGAVHAQ MHAAVGQLGR ARAETEELIR ERVRQVVAHV RAQERELLEA
     VDARYQRDYE EMASRLGRLD AVLQRIRTGS ALVQRMKCYA SDQEVLDMHG FLRQALCRLR
     QEEPQSLQAA VRTDGFDEFK VRLQDLSSCI TQGKAIETQS SSSEEIVPSP PSPPPLPRIY
     KPCFVCQDKS SGYHYGVSAC EGCKGFFRRS IQKNMVYTCH RDKNCIINKV TRNRCQYCRL
     QKCFEVGMSK ESVRNDRNKK KKEVPKPECS ESYTLTPEVG ELIEKVRKAH QETFPALCQL
     GKYTTNNSSE QRVSLDIDLW DKFSELSTKC IIKTVEFAKQ LPGFTTLTIA DQITLLKAAC
     LDILILRICT RYTPEQDTMT FSDGLTLNRT QMHNAGFGPL TDLVFAFANQ LLPLEMDDAE
     TGLLSAICLI CGDRQDLEQP DRVDMLQEPL LEALKVYVRK RRPSRPHMFP KMLMKITDLR
     SISAKGAERV ITLKMEIPGS MPPLIQEMLE NSEGLDTLSG QPGGGGRDGG GLAPPPGSCS
     PSLSPSSNRS SPATHSP
//