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Q15156 (Q15156_HUMAN) Unreviewed, UniProtKB/TrEMBL

Last modified May 29, 2013. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesSubmitted name:
PML-RAR protein EMBL AAA60126.1
Gene names
Name:PML-RAR EMBL AAA60126.1
OrganismHomo sapiens (Human) EMBL AAA60126.1
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length797 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the nuclear hormone receptor family. RuleBase RU000377

Contains 1 RING-type zinc finger.

Contains 1 nuclear receptor DNA-binding domain. SAAS SAAS000536

Sequences

Sequence LengthMass (Da)Tools
Q15156 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 8C16B6E85CBDD214

FASTA79789,282
        10         20         30         40         50         60 
MEPAPARSPR PQQDPARPQE PTMPPPETPS EGRQPSPSPS PTERAPASEE EFQFLRCQQC 

        70         80         90        100        110        120 
QAEAKCPKLL PCLHTLCSGC LEASGMQCPI CQAPWPLGAD TPALDNVFFE SLQRRLSVYR 

       130        140        150        160        170        180 
QIVDAQAVCT RCKESADFWC FECEQLLCAK CFEAHQWFLK HEARPLAELR NQSVREFLDG 

       190        200        210        220        230        240 
TRKTNNIFCS NPNHRTPTLT SIYCRGCSKP LCCSCALLDS SHSELKCDIS AEIQQRQEEL 

       250        260        270        280        290        300 
DAMTQALQEQ DSAFGAVHAQ MHAAVGQLGR ARAETEELIR ERVRQVVAHV RAQERELLEA 

       310        320        330        340        350        360 
VDARYQRDYE EMASRLGRLD AVLQRIRTGS ALVQRMKCYA SDQEVLDMHG FLRQALCRLR 

       370        380        390        400        410        420 
QEEPQSLQAA VRTDGFDEFK VRLQDLSSCI TQGKAIETQS SSSEEIVPSP PSPPPLPRIY 

       430        440        450        460        470        480 
KPCFVCQDKS SGYHYGVSAC EGCKGFFRRS IQKNMVYTCH RDKNCIINKV TRNRCQYCRL 

       490        500        510        520        530        540 
QKCFEVGMSK ESVRNDRNKK KKEVPKPECS ESYTLTPEVG ELIEKVRKAH QETFPALCQL 

       550        560        570        580        590        600 
GKYTTNNSSE QRVSLDIDLW DKFSELSTKC IIKTVEFAKQ LPGFTTLTIA DQITLLKAAC 

       610        620        630        640        650        660 
LDILILRICT RYTPEQDTMT FSDGLTLNRT QMHNAGFGPL TDLVFAFANQ LLPLEMDDAE 

       670        680        690        700        710        720 
TGLLSAICLI CGDRQDLEQP DRVDMLQEPL LEALKVYVRK RRPSRPHMFP KMLMKITDLR 

       730        740        750        760        770        780 
SISAKGAERV ITLKMEIPGS MPPLIQEMLE NSEGLDTLSG QPGGGGRDGG GLAPPPGSCS 

       790 
PSLSPSSNRS SPATHSP

« Hide

References

[1]"Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML."
Kakizuka A., Miller W.H. Jr., Umenono K., Warrell R.P. Jr., Frankel S.R., Murty V.V., Dmitrovsky E., Evans R.M.
Cell 66:663-674(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
[2]"The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR."
de The H., Lavau C., Marchio A., Chomienne C., Degos L., Dejean A.
Cell 66:675-684(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M73779 mRNA. Translation: AAA60126.1.
IPIIPI00876842.
PIRC40045.

3D structure databases

ProteinModelPortalQ15156.
SMRQ15156. Positions 49-104, 422-496, 517-751.
ModBaseSearch...

Protein-protein interaction databases

IntActQ15156. 8 interactions.

Proteomic databases

PRIDEQ15156.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.565.10. 1 hit.
3.30.40.10. 1 hit.
3.30.50.10. 1 hit.
InterProIPR021978. DUF3583.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR000315. Znf_B-box.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamPF12126. DUF3583. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTSM00336. BBOX. 1 hit.
SM00430. HOLI. 1 hit.
SM00184. RING. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMSSF48508. Str_ncl_receptor. 1 hit.
PROSITEPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio35538087.

Entry information

Entry nameQ15156_HUMAN
AccessionPrimary (citable) accession number: Q15156
Entry history
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 29, 2013
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.
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