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Q15156

- Q15156_HUMAN

UniProt

Q15156 - Q15156_HUMAN

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Protein
Submitted name:

PML-RAR protein

Gene
PML-RAR
Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. retinoic acid receptor activity Source: InterPro
  3. sequence-specific DNA binding Source: InterPro
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  5. steroid hormone receptor activity Source: InterPro
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. negative regulation of extrinsic apoptotic signaling pathway Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

ReceptorUniRule annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotationSAAS annotations

Keywords - Ligandi

DNA-bindingUniRule annotationSAAS annotations, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Submitted name:
PML-RAR proteinImported
Gene namesi
Name:PML-RARImported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

GO - Cellular componenti

  1. death-inducing signaling complex Source: UniProtKB
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotations

PTM / Processingi

Proteomic databases

MaxQBiQ15156.
PRIDEiQ15156.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EEDO755302EBI-867256,EBI-923794
EZH2Q159108EBI-867256,EBI-530054
FASP254456EBI-867256,EBI-494743
MBD1Q9UIS94EBI-867256,EBI-867196
NCOR2Q9Y6182EBI-867256,EBI-80830
PHF8Q9UPP1-26EBI-867256,EBI-6601215
SPI1P1794720EBI-867256,EBI-2293548
SUZ12Q150226EBI-867256,EBI-1264675

Protein-protein interaction databases

IntActiQ15156. 10 interactions.

Structurei

3D structure databases

ProteinModelPortaliQ15156.
SMRiQ15156. Positions 49-104, 422-496, 517-751.

Family & Domainsi

Sequence similaritiesi

Belongs to the nuclear hormone receptor family.UniRule annotation
Contains RING-type zinc finger.SAAS annotations
Contains nuclear receptor DNA-binding domain.SAAS annotations

Keywords - Domaini

Zinc-fingerUniRule annotationSAAS annotations

Family and domain databases

Gene3Di1.10.565.10. 1 hit.
3.30.40.10. 1 hit.
3.30.50.10. 1 hit.
InterProiIPR021978. DUF3583.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR000315. Znf_B-box.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view]
PfamiPF12126. DUF3583. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00336. BBOX. 1 hit.
SM00430. HOLI. 1 hit.
SM00184. RING. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15156-1 [UniParc]FASTAAdd to Basket

« Hide

MEPAPARSPR PQQDPARPQE PTMPPPETPS EGRQPSPSPS PTERAPASEE    50
EFQFLRCQQC QAEAKCPKLL PCLHTLCSGC LEASGMQCPI CQAPWPLGAD 100
TPALDNVFFE SLQRRLSVYR QIVDAQAVCT RCKESADFWC FECEQLLCAK 150
CFEAHQWFLK HEARPLAELR NQSVREFLDG TRKTNNIFCS NPNHRTPTLT 200
SIYCRGCSKP LCCSCALLDS SHSELKCDIS AEIQQRQEEL DAMTQALQEQ 250
DSAFGAVHAQ MHAAVGQLGR ARAETEELIR ERVRQVVAHV RAQERELLEA 300
VDARYQRDYE EMASRLGRLD AVLQRIRTGS ALVQRMKCYA SDQEVLDMHG 350
FLRQALCRLR QEEPQSLQAA VRTDGFDEFK VRLQDLSSCI TQGKAIETQS 400
SSSEEIVPSP PSPPPLPRIY KPCFVCQDKS SGYHYGVSAC EGCKGFFRRS 450
IQKNMVYTCH RDKNCIINKV TRNRCQYCRL QKCFEVGMSK ESVRNDRNKK 500
KKEVPKPECS ESYTLTPEVG ELIEKVRKAH QETFPALCQL GKYTTNNSSE 550
QRVSLDIDLW DKFSELSTKC IIKTVEFAKQ LPGFTTLTIA DQITLLKAAC 600
LDILILRICT RYTPEQDTMT FSDGLTLNRT QMHNAGFGPL TDLVFAFANQ 650
LLPLEMDDAE TGLLSAICLI CGDRQDLEQP DRVDMLQEPL LEALKVYVRK 700
RRPSRPHMFP KMLMKITDLR SISAKGAERV ITLKMEIPGS MPPLIQEMLE 750
NSEGLDTLSG QPGGGGRDGG GLAPPPGSCS PSLSPSSNRS SPATHSP 797
Length:797
Mass (Da):89,282
Last modified:November 1, 1996 - v1
Checksum:i8C16B6E85CBDD214
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73779 mRNA. Translation: AAA60126.1.
PIRiC40045.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M73779 mRNA. Translation: AAA60126.1 .
PIRi C40045.

3D structure databases

ProteinModelPortali Q15156.
SMRi Q15156. Positions 49-104, 422-496, 517-751.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q15156. 10 interactions.

Proteomic databases

MaxQBi Q15156.
PRIDEi Q15156.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

NextBioi 35538087.

Family and domain databases

Gene3Di 1.10.565.10. 1 hit.
3.30.40.10. 1 hit.
3.30.50.10. 1 hit.
InterProi IPR021978. DUF3583.
IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003078. Retinoic_acid_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR000315. Znf_B-box.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
IPR017907. Znf_RING_CS.
[Graphical view ]
Pfami PF12126. DUF3583. 1 hit.
PF00104. Hormone_recep. 1 hit.
PF00643. zf-B_box. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01292. RETNOICACIDR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00336. BBOX. 1 hit.
SM00430. HOLI. 1 hit.
SM00184. RING. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
PS50119. ZF_BBOX. 2 hits.
PS00518. ZF_RING_1. 1 hit.
PS50089. ZF_RING_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML."
    Kakizuka A., Miller W.H. Jr., Umenono K., Warrell R.P. Jr., Frankel S.R., Murty V.V., Dmitrovsky E., Evans R.M.
    Cell 66:663-674(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. "The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR."
    de The H., Lavau C., Marchio A., Chomienne C., Degos L., Dejean A.
    Cell 66:675-684(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiQ15156_HUMAN
AccessioniPrimary (citable) accession number: Q15156
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: June 11, 2014
This is version 94 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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