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Q15156

- Q15156_HUMAN

UniProt

Q15156 - Q15156_HUMAN

Protein
Submitted name:

PML-RAR protein

Gene

PML-RAR

Organism
Homo sapiens (Human)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 95 (01 Oct 2014)
      Sequence version 1 (01 Nov 1996)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. retinoic acid receptor activity Source: InterPro
    3. sequence-specific DNA binding Source: InterPro
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. steroid hormone receptor activity Source: InterPro
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. negative regulation of extrinsic apoptotic signaling pathway Source: UniProtKB

    Keywords - Molecular functioni

    ReceptorUniRule annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation, Metal-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    PML-RAR proteinImported
    Gene namesi
    Name:PML-RARImported
    OrganismiHomo sapiens (Human)Imported
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

    Subcellular locationi

    GO - Cellular componenti

    1. death-inducing signaling complex Source: UniProtKB
    2. nucleus Source: UniProtKB-KW

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    PTM / Processingi

    Proteomic databases

    MaxQBiQ15156.
    PRIDEiQ15156.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EEDO755302EBI-867256,EBI-923794
    EZH2Q159108EBI-867256,EBI-530054
    FASP254456EBI-867256,EBI-494743
    MBD1Q9UIS94EBI-867256,EBI-867196
    NCOR2Q9Y6182EBI-867256,EBI-80830
    PHF8Q9UPP1-26EBI-867256,EBI-6601215
    SPI1P1794720EBI-867256,EBI-2293548
    SUZ12Q150226EBI-867256,EBI-1264675

    Protein-protein interaction databases

    IntActiQ15156. 10 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ15156.
    SMRiQ15156. Positions 49-104, 422-496, 517-751.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the nuclear hormone receptor family.UniRule annotation
    Contains RING-type zinc finger.SAAS annotation
    Contains nuclear receptor DNA-binding domain.SAAS annotation

    Keywords - Domaini

    Zinc-fingerUniRule annotationSAAS annotation

    Family and domain databases

    Gene3Di1.10.565.10. 1 hit.
    3.30.40.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProiIPR021978. DUF3583.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003078. Retinoic_acid_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR000315. Znf_B-box.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view]
    PfamiPF12126. DUF3583. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF00643. zf-B_box. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01292. RETNOICACIDR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00336. BBOX. 1 hit.
    SM00430. HOLI. 1 hit.
    SM00184. RING. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    PS50119. ZF_BBOX. 2 hits.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q15156-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPAPARSPR PQQDPARPQE PTMPPPETPS EGRQPSPSPS PTERAPASEE    50
    EFQFLRCQQC QAEAKCPKLL PCLHTLCSGC LEASGMQCPI CQAPWPLGAD 100
    TPALDNVFFE SLQRRLSVYR QIVDAQAVCT RCKESADFWC FECEQLLCAK 150
    CFEAHQWFLK HEARPLAELR NQSVREFLDG TRKTNNIFCS NPNHRTPTLT 200
    SIYCRGCSKP LCCSCALLDS SHSELKCDIS AEIQQRQEEL DAMTQALQEQ 250
    DSAFGAVHAQ MHAAVGQLGR ARAETEELIR ERVRQVVAHV RAQERELLEA 300
    VDARYQRDYE EMASRLGRLD AVLQRIRTGS ALVQRMKCYA SDQEVLDMHG 350
    FLRQALCRLR QEEPQSLQAA VRTDGFDEFK VRLQDLSSCI TQGKAIETQS 400
    SSSEEIVPSP PSPPPLPRIY KPCFVCQDKS SGYHYGVSAC EGCKGFFRRS 450
    IQKNMVYTCH RDKNCIINKV TRNRCQYCRL QKCFEVGMSK ESVRNDRNKK 500
    KKEVPKPECS ESYTLTPEVG ELIEKVRKAH QETFPALCQL GKYTTNNSSE 550
    QRVSLDIDLW DKFSELSTKC IIKTVEFAKQ LPGFTTLTIA DQITLLKAAC 600
    LDILILRICT RYTPEQDTMT FSDGLTLNRT QMHNAGFGPL TDLVFAFANQ 650
    LLPLEMDDAE TGLLSAICLI CGDRQDLEQP DRVDMLQEPL LEALKVYVRK 700
    RRPSRPHMFP KMLMKITDLR SISAKGAERV ITLKMEIPGS MPPLIQEMLE 750
    NSEGLDTLSG QPGGGGRDGG GLAPPPGSCS PSLSPSSNRS SPATHSP 797
    Length:797
    Mass (Da):89,282
    Last modified:November 1, 1996 - v1
    Checksum:i8C16B6E85CBDD214
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73779 mRNA. Translation: AAA60126.1.
    PIRiC40045.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M73779 mRNA. Translation: AAA60126.1 .
    PIRi C40045.

    3D structure databases

    ProteinModelPortali Q15156.
    SMRi Q15156. Positions 49-104, 422-496, 517-751.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q15156. 10 interactions.

    Proteomic databases

    MaxQBi Q15156.
    PRIDEi Q15156.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    NextBioi 35538087.

    Family and domain databases

    Gene3Di 1.10.565.10. 1 hit.
    3.30.40.10. 1 hit.
    3.30.50.10. 1 hit.
    InterProi IPR021978. DUF3583.
    IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003078. Retinoic_acid_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR000315. Znf_B-box.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    IPR001841. Znf_RING.
    IPR013083. Znf_RING/FYVE/PHD.
    IPR017907. Znf_RING_CS.
    [Graphical view ]
    Pfami PF12126. DUF3583. 1 hit.
    PF00104. Hormone_recep. 1 hit.
    PF00643. zf-B_box. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01292. RETNOICACIDR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00336. BBOX. 1 hit.
    SM00430. HOLI. 1 hit.
    SM00184. RING. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    PS50119. ZF_BBOX. 2 hits.
    PS00518. ZF_RING_1. 1 hit.
    PS50089. ZF_RING_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Chromosomal translocation t(15;17) in human acute promyelocytic leukemia fuses RAR alpha with a novel putative transcription factor, PML."
      Kakizuka A., Miller W.H. Jr., Umenono K., Warrell R.P. Jr., Frankel S.R., Murty V.V., Dmitrovsky E., Evans R.M.
      Cell 66:663-674(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. "The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR."
      de The H., Lavau C., Marchio A., Chomienne C., Degos L., Dejean A.
      Cell 66:675-684(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.

    Entry informationi

    Entry nameiQ15156_HUMAN
    AccessioniPrimary (citable) accession number: Q15156
    Entry historyi
    Integrated into UniProtKB/TrEMBL: November 1, 1996
    Last sequence update: November 1, 1996
    Last modified: October 1, 2014
    This is version 95 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.