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Protein

Nodal modulator 1

Gene

NOMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May antagonize Nodal signaling.By similarity

GO - Molecular functioni

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Nodal modulator 1
Alternative name(s):
pM5 protein
Gene namesi
Name:NOMO1
Synonyms:PM5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30060. NOMO1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 11551124ExtracellularSequence analysisAdd
BLAST
Transmembranei1156 – 117621HelicalSequence analysisAdd
BLAST
Topological domaini1177 – 122246CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA134934458.

Polymorphism and mutation databases

BioMutaiNOMO1.
DMDMi296439497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence analysisAdd
BLAST
Chaini32 – 12221191Nodal modulator 1PRO_0000021819Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi50 – 501N-linked (GlcNAc...)Sequence analysis
Glycosylationi218 – 2181N-linked (GlcNAc...)Sequence analysis
Glycosylationi618 – 6181N-linked (GlcNAc...)1 Publication
Modified residuei1205 – 12051PhosphoserineBy similarity

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15155.
MaxQBiQ15155.
PaxDbiQ15155.
PRIDEiQ15155.

PTM databases

iPTMnetiQ15155.
PhosphoSiteiQ15155.
SwissPalmiQ15155.

Expressioni

Tissue specificityi

Expressed in colon tumor tissue and in adjacent normal colonic mucosa.

Developmental stagei

No difference between normal colonic mucosa and colon tumor tissue in mRNA expression, whereas the protein is expressed 1.5-fold more in normal colonic mucosa that in colon tumor tissue.

Gene expression databases

BgeeiQ15155.
CleanExiHS_NOMO1.
ExpressionAtlasiQ15155. baseline and differential.
GenevisibleiQ15155. HS.

Organism-specific databases

HPAiCAB025192.
HPA046697.
HPA047245.
HPA061174.

Interactioni

Protein-protein interaction databases

BioGridi116991. 22 interactions.
IntActiQ15155. 11 interactions.
MINTiMINT-1199269.
STRINGi9606.ENSP00000287667.

Structurei

3D structure databases

ProteinModelPortaliQ15155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1948. Eukaryota.
ENOG410XTI0. LUCA.
GeneTreeiENSGT00390000000089.
HOGENOMiHOG000230623.
HOVERGENiHBG023764.
InParanoidiQ15155.
OrthoDBiEOG77M8NC.
PhylomeDBiQ15155.
TreeFamiTF313696.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1120. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVGQGAGPL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN
60 70 80 90 100
YSLIEIKLYT KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF
110 120 130 140 150
EPTTVELHVD GVSDICTKGG DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS
160 170 180 190 200
LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD YEILATHPTW ALKEASTTVR
210 220 230 240 250
VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS LVTKEDVLGC
260 270 280 290 300
NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI
310 320 330 340 350
TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT
360 370 380 390 400
LNNQIKVKTK ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL
410 420 430 440 450
ADIIATGFSV CGQISIIRFP DTVKQMNKYK VVLSSQDKDK SLVTVETDAH
460 470 480 490 500
GSFCFKAKPG TYKVQVMVPE AETRAGLTLK PQTFPLTVTN RPMMDVAFVQ
510 520 530 540 550
FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV NAMTFTFDNV
560 570 580 590 600
LPGKYKISIM HEDWCWKNKS LEVEVLEDDM SAVEFRQTGY MLRCSLSHAI
610 620 630 640 650
TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT
660 670 680 690 700
YDTSSPSILT LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK
710 720 730 740 750
SVQELRREQQ LAEIEARRQE REKNGNEEGE ERMTKPPVQE MVDELQGPFS
760 770 780 790 800
YDFSYWARSG EKITVTPSSK ELLFYPPSME AVVSGESCPG KLIEIHGKAG
810 820 830 840 850
LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV GPLHSDLEYT
860 870 880 890 900
VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG
910 920 930 940 950
LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL
960 970 980 990 1000
KITITGYRTA YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE
1010 1020 1030 1040 1050
GKFRLRGLLP GCVYHVQLKA EGNDHIERAL PHHRVIEVGN NDIDDVNIIV
1060 1070 1080 1090 1100
FRQINQFDLS GNVITSSEYL PTLWVKLYKS ENLDNPIQTV SLGQSLFFHF
1110 1120 1130 1140 1150
PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH ITLIFNPTRK
1160 1170 1180 1190 1200
LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVRALGQA
1210 1220
ASDNSGPEDA KRQAKKQKTR RT
Length:1,222
Mass (Da):134,324
Last modified:May 18, 2010 - v5
Checksum:iEE0A3BB552BAB72B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti33 – 353EDI → RDL in CAA40655 (PubMed:1310294).Curated
Sequence conflicti200 – 2001R → S in CAA40655 (PubMed:1310294).Curated
Sequence conflicti513 – 5131D → N in CAA40655 (PubMed:1310294).Curated
Sequence conflicti618 – 6181N → S in CAA40655 (PubMed:1310294).Curated
Sequence conflicti620 – 6201S → F in CAA40655 (PubMed:1310294).Curated
Sequence conflicti650 – 6501T → I in CAA40655 (PubMed:1310294).Curated
Sequence conflicti659 – 6591L → F in CAA40655 (PubMed:1310294).Curated
Sequence conflicti1141 – 11411I → T in CAA40655 (PubMed:1310294).Curated
Sequence conflicti1196 – 11961A → V in AAH65535 (PubMed:15489334).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti404 – 4041I → V.1 Publication
Corresponds to variant rs11554240 [ dbSNP | Ensembl ].
VAR_013312
Natural varianti458 – 4581K → N.1 Publication
VAR_013313
Natural varianti490 – 4901N → D.1 Publication
Corresponds to variant rs117835774 [ dbSNP | Ensembl ].
VAR_013314
Natural varianti493 – 4931M → V.
Corresponds to variant rs141860762 [ dbSNP | Ensembl ].
VAR_022551
Natural varianti580 – 5801M → V.
Corresponds to variant rs141510032 [ dbSNP | Ensembl ].
VAR_056956
Natural varianti583 – 5831V → A.1 Publication
Corresponds to variant rs17855981 [ dbSNP | Ensembl ].
VAR_060370
Natural varianti1081 – 10811E → K.1 Publication
VAR_011496
Natural varianti1141 – 11411I → F.1 Publication
Corresponds to variant rs376397163 [ dbSNP | Ensembl ].
VAR_013315
Natural varianti1195 – 11951R → G.1 Publication
VAR_013316

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136443 Genomic DNA. No translation available.
BC065535 mRNA. Translation: AAH65535.1.
X57398 mRNA. Translation: CAA40655.1.
CCDSiCCDS10556.1.
PIRiS21977.
RefSeqiNP_055102.3. NM_014287.3.
UniGeneiHs.743963.

Genome annotation databases

EnsembliENST00000287667; ENSP00000287667; ENSG00000103512.
ENST00000619292; ENSP00000482008; ENSG00000274779.
GeneIDi23420.
KEGGihsa:23420.
UCSCiuc002dcv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136443 Genomic DNA. No translation available.
BC065535 mRNA. Translation: AAH65535.1.
X57398 mRNA. Translation: CAA40655.1.
CCDSiCCDS10556.1.
PIRiS21977.
RefSeqiNP_055102.3. NM_014287.3.
UniGeneiHs.743963.

3D structure databases

ProteinModelPortaliQ15155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116991. 22 interactions.
IntActiQ15155. 11 interactions.
MINTiMINT-1199269.
STRINGi9606.ENSP00000287667.

PTM databases

iPTMnetiQ15155.
PhosphoSiteiQ15155.
SwissPalmiQ15155.

Polymorphism and mutation databases

BioMutaiNOMO1.
DMDMi296439497.

Proteomic databases

EPDiQ15155.
MaxQBiQ15155.
PaxDbiQ15155.
PRIDEiQ15155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287667; ENSP00000287667; ENSG00000103512.
ENST00000619292; ENSP00000482008; ENSG00000274779.
GeneIDi23420.
KEGGihsa:23420.
UCSCiuc002dcv.4. human.

Organism-specific databases

CTDi23420.
GeneCardsiNOMO1.
H-InvDBHIX0023257.
HGNCiHGNC:30060. NOMO1.
HPAiCAB025192.
HPA046697.
HPA047245.
HPA061174.
MIMi609157. gene.
neXtProtiNX_Q15155.
PharmGKBiPA134934458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1948. Eukaryota.
ENOG410XTI0. LUCA.
GeneTreeiENSGT00390000000089.
HOGENOMiHOG000230623.
HOVERGENiHBG023764.
InParanoidiQ15155.
OrthoDBiEOG77M8NC.
PhylomeDBiQ15155.
TreeFamiTF313696.

Miscellaneous databases

ChiTaRSiNOMO1. human.
GeneWikiiNOMO1.
GenomeRNAii23420.
PROiQ15155.
SOURCEiSearch...

Gene expression databases

BgeeiQ15155.
CleanExiHS_NOMO1.
ExpressionAtlasiQ15155. baseline and differential.
GenevisibleiQ15155. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1120. 1 hit.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The sequence and analysis of duplication-rich human chromosome 16."
    Martin J., Han C., Gordon L.A., Terry A., Prabhakar S., She X., Xie G., Hellsten U., Chan Y.M., Altherr M., Couronne O., Aerts A., Bajorek E., Black S., Blumer H., Branscomb E., Brown N.C., Bruno W.J.
    , Buckingham J.M., Callen D.F., Campbell C.S., Campbell M.L., Campbell E.W., Caoile C., Challacombe J.F., Chasteen L.A., Chertkov O., Chi H.C., Christensen M., Clark L.M., Cohn J.D., Denys M., Detter J.C., Dickson M., Dimitrijevic-Bussod M., Escobar J., Fawcett J.J., Flowers D., Fotopulos D., Glavina T., Gomez M., Gonzales E., Goodstein D., Goodwin L.A., Grady D.L., Grigoriev I., Groza M., Hammon N., Hawkins T., Haydu L., Hildebrand C.E., Huang W., Israni S., Jett J., Jewett P.B., Kadner K., Kimball H., Kobayashi A., Krawczyk M.-C., Leyba T., Longmire J.L., Lopez F., Lou Y., Lowry S., Ludeman T., Manohar C.F., Mark G.A., McMurray K.L., Meincke L.J., Morgan J., Moyzis R.K., Mundt M.O., Munk A.C., Nandkeshwar R.D., Pitluck S., Pollard M., Predki P., Parson-Quintana B., Ramirez L., Rash S., Retterer J., Ricke D.O., Robinson D.L., Rodriguez A., Salamov A., Saunders E.H., Scott D., Shough T., Stallings R.L., Stalvey M., Sutherland R.D., Tapia R., Tesmer J.G., Thayer N., Thompson L.S., Tice H., Torney D.C., Tran-Gyamfi M., Tsai M., Ulanovsky L.E., Ustaszewska A., Vo N., White P.S., Williams A.L., Wills P.L., Wu J.-R., Wu K., Yang J., DeJong P., Bruce D., Doggett N.A., Deaven L., Schmutz J., Grimwood J., Richardson P., Rokhsar D.S., Eichler E.E., Gilna P., Lucas S.M., Myers R.M., Rubin E.M., Pennacchio L.A.
    Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ALA-583.
    Tissue: Lung.
  3. "Cloning and characterization of a novel human cDNA that has DNA similarity to the conserved region of the collagenase gene family."
    Templeton N.S., Rodgers L.A., Levy A.T., Ting K.-L., Krutzsch H.C., Liotta L.A., Stetler-Stevenson W.G.
    Genomics 12:175-176(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 33-1222.
    Tissue: Melanoma.
  4. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-618.
    Tissue: Liver.
  5. Cited for: VARIANT LYS-1081.
  6. "Identification of novel polymorphisms in the pM5 and MRP1 (ABCC1) genes at locus 16p13.1 and exclusion of both genes as responsible for pseudoxanthoma elasticum."
    Perdu J., Germain D.P.
    Hum. Mutat. 17:74-75(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS VAL-404; ASN-458; ASP-490; PHE-1141 AND GLY-1195.

Entry informationi

Entry nameiNOMO1_HUMAN
AccessioniPrimary (citable) accession number: Q15155
Secondary accession number(s): P78421, Q8IW21, Q96DG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 18, 2010
Last modified: June 8, 2016
This is version 151 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1, NOMO2 (AC Q5JPE7) and NOMO3 (AC P69849). All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members. Moreover, it does not allow a clear view of which variant belongs to which of the 3 copies. The results reported in other entries may therefore apply for this protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.