Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nodal modulator 1

Gene

NOMO1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

May antagonize Nodal signaling.By similarity

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103512-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Nodal modulator 1
Alternative name(s):
pM5 protein
Gene namesi
Name:NOMO1
Synonyms:PM5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

HGNCiHGNC:30060. NOMO1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini32 – 1155ExtracellularSequence analysisAdd BLAST1124
Transmembranei1156 – 1176HelicalSequence analysisAdd BLAST21
Topological domaini1177 – 1222CytoplasmicSequence analysisAdd BLAST46

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi23420.
OpenTargetsiENSG00000103512.
ENSG00000274779.
PharmGKBiPA134934458.

Polymorphism and mutation databases

BioMutaiNOMO1.
DMDMi296439497.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000002181932 – 1222Nodal modulator 1Add BLAST1191

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Glycosylationi218N-linked (GlcNAc...)Sequence analysis1
Glycosylationi618N-linked (GlcNAc...)1 Publication1
Modified residuei1205PhosphoserineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ15155.
MaxQBiQ15155.
PaxDbiQ15155.
PeptideAtlasiQ15155.
PRIDEiQ15155.

PTM databases

iPTMnetiQ15155.
PhosphoSitePlusiQ15155.
SwissPalmiQ15155.

Expressioni

Tissue specificityi

Expressed in colon tumor tissue and in adjacent normal colonic mucosa.

Developmental stagei

No difference between normal colonic mucosa and colon tumor tissue in mRNA expression, whereas the protein is expressed 1.5-fold more in normal colonic mucosa that in colon tumor tissue.

Gene expression databases

BgeeiENSG00000103512.
CleanExiHS_NOMO1.
ExpressionAtlasiQ15155. baseline and differential.
GenevisibleiQ15155. HS.

Organism-specific databases

HPAiCAB025192.
HPA046697.
HPA047245.
HPA061174.

Interactioni

Protein-protein interaction databases

BioGridi116991. 22 interactors.
IntActiQ15155. 11 interactors.
MINTiMINT-1199269.
STRINGi9606.ENSP00000287667.

Structurei

3D structure databases

ProteinModelPortaliQ15155.
SMRiQ15155.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1948. Eukaryota.
ENOG410XTI0. LUCA.
GeneTreeiENSGT00390000000089.
HOGENOMiHOG000230623.
HOVERGENiHBG023764.
InParanoidiQ15155.
PhylomeDBiQ15155.
TreeFamiTF313696.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1120. 2 hits.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q15155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLVGQGAGPL GPAVVTAAVV LLLSGVGPAH GSEDIVVGCG GFVKSDVEIN
60 70 80 90 100
YSLIEIKLYT KHGTLKYQTD CAPNNGYFMI PLYDKGDFIL KIEPPLGWSF
110 120 130 140 150
EPTTVELHVD GVSDICTKGG DINFVFTGFS VNGKVLSKGQ PLGPAGVQVS
160 170 180 190 200
LRNTGTEAKI QSTVTQPGGK FAFFKVLPGD YEILATHPTW ALKEASTTVR
210 220 230 240 250
VTNSNANAAS PLIVAGYNVS GSVRSDGEPM KGVKFLLFSS LVTKEDVLGC
260 270 280 290 300
NVSPVPGFQP QDESLVYLCY TVSREDGSFS FYSLPSGGYT VIPFYRGERI
310 320 330 340 350
TFDVAPSRLD FTVEHDSLKI EPVFHVMGFS VTGRVLNGPE GDGVPEAVVT
360 370 380 390 400
LNNQIKVKTK ADGSFRLENI TTGTYTIHAQ KEHLYFETVT IKIAPNTPQL
410 420 430 440 450
ADIIATGFSV CGQISIIRFP DTVKQMNKYK VVLSSQDKDK SLVTVETDAH
460 470 480 490 500
GSFCFKAKPG TYKVQVMVPE AETRAGLTLK PQTFPLTVTN RPMMDVAFVQ
510 520 530 540 550
FLASVSGKVS CLDTCGDLLV TLQSLSRQGE KRSLQLSGKV NAMTFTFDNV
560 570 580 590 600
LPGKYKISIM HEDWCWKNKS LEVEVLEDDM SAVEFRQTGY MLRCSLSHAI
610 620 630 640 650
TLEFYQDGNG RENVGIYNLS KGVNRFCLSK PGVYKVTPRS CHRFEQAFYT
660 670 680 690 700
YDTSSPSILT LTAIRHHVLG TITTDKMMDV TVTIKSSIDS EPALVLGPLK
710 720 730 740 750
SVQELRREQQ LAEIEARRQE REKNGNEEGE ERMTKPPVQE MVDELQGPFS
760 770 780 790 800
YDFSYWARSG EKITVTPSSK ELLFYPPSME AVVSGESCPG KLIEIHGKAG
810 820 830 840 850
LFLEGQIHPE LEGVEIVISE KGASSPLITV FTDDKGAYSV GPLHSDLEYT
860 870 880 890 900
VTSQKEGYVL TAVEGTIGDF KAYALAGVSF EIKAEDDQPL PGVLLSLSGG
910 920 930 940 950
LFRSNLLTQD NGILTFSNLS PGQYYFKPMM KEFRFEPSSQ MIEVQEGQNL
960 970 980 990 1000
KITITGYRTA YSCYGTVSSL NGEPEQGVAM EAVGQNDCSI YGEDTVTDEE
1010 1020 1030 1040 1050
GKFRLRGLLP GCVYHVQLKA EGNDHIERAL PHHRVIEVGN NDIDDVNIIV
1060 1070 1080 1090 1100
FRQINQFDLS GNVITSSEYL PTLWVKLYKS ENLDNPIQTV SLGQSLFFHF
1110 1120 1130 1140 1150
PPLLRDGENY VVLLDSTLPR SQYDYILPQV SFTAVGYHKH ITLIFNPTRK
1160 1170 1180 1190 1200
LPEQDIAQGS YIALPLTLLV LLAGYNHDKL IPLLLQLTSR LQGVRALGQA
1210 1220
ASDNSGPEDA KRQAKKQKTR RT
Length:1,222
Mass (Da):134,324
Last modified:May 18, 2010 - v5
Checksum:iEE0A3BB552BAB72B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti33 – 35EDI → RDL in CAA40655 (PubMed:1310294).Curated3
Sequence conflicti200R → S in CAA40655 (PubMed:1310294).Curated1
Sequence conflicti513D → N in CAA40655 (PubMed:1310294).Curated1
Sequence conflicti618N → S in CAA40655 (PubMed:1310294).Curated1
Sequence conflicti620S → F in CAA40655 (PubMed:1310294).Curated1
Sequence conflicti650T → I in CAA40655 (PubMed:1310294).Curated1
Sequence conflicti659L → F in CAA40655 (PubMed:1310294).Curated1
Sequence conflicti1141I → T in CAA40655 (PubMed:1310294).Curated1
Sequence conflicti1196A → V in AAH65535 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_013312404I → V.1 PublicationCorresponds to variant rs11554240dbSNPEnsembl.1
Natural variantiVAR_013313458K → N.1 Publication1
Natural variantiVAR_013314490N → D.1 PublicationCorresponds to variant rs117835774dbSNPEnsembl.1
Natural variantiVAR_022551493M → V.Corresponds to variant rs141860762dbSNPEnsembl.1
Natural variantiVAR_056956580M → V.Corresponds to variant rs141510032dbSNPEnsembl.1
Natural variantiVAR_060370583V → A.1 PublicationCorresponds to variant rs17855981dbSNPEnsembl.1
Natural variantiVAR_0114961081E → K.1 PublicationCorresponds to variant rs200317822dbSNPEnsembl.1
Natural variantiVAR_0133151141I → F.1 PublicationCorresponds to variant rs376397163dbSNPEnsembl.1
Natural variantiVAR_0133161195R → G.1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136443 Genomic DNA. No translation available.
BC065535 mRNA. Translation: AAH65535.1.
X57398 mRNA. Translation: CAA40655.1.
CCDSiCCDS10556.1.
PIRiS21977.
RefSeqiNP_055102.3. NM_014287.3.
UniGeneiHs.743963.

Genome annotation databases

EnsembliENST00000287667; ENSP00000287667; ENSG00000103512.
ENST00000619292; ENSP00000482008; ENSG00000274779.
GeneIDi23420.
KEGGihsa:23420.
UCSCiuc002dcv.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC136443 Genomic DNA. No translation available.
BC065535 mRNA. Translation: AAH65535.1.
X57398 mRNA. Translation: CAA40655.1.
CCDSiCCDS10556.1.
PIRiS21977.
RefSeqiNP_055102.3. NM_014287.3.
UniGeneiHs.743963.

3D structure databases

ProteinModelPortaliQ15155.
SMRiQ15155.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116991. 22 interactors.
IntActiQ15155. 11 interactors.
MINTiMINT-1199269.
STRINGi9606.ENSP00000287667.

PTM databases

iPTMnetiQ15155.
PhosphoSitePlusiQ15155.
SwissPalmiQ15155.

Polymorphism and mutation databases

BioMutaiNOMO1.
DMDMi296439497.

Proteomic databases

EPDiQ15155.
MaxQBiQ15155.
PaxDbiQ15155.
PeptideAtlasiQ15155.
PRIDEiQ15155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000287667; ENSP00000287667; ENSG00000103512.
ENST00000619292; ENSP00000482008; ENSG00000274779.
GeneIDi23420.
KEGGihsa:23420.
UCSCiuc002dcv.4. human.

Organism-specific databases

CTDi23420.
DisGeNETi23420.
GeneCardsiNOMO1.
H-InvDBHIX0023257.
HGNCiHGNC:30060. NOMO1.
HPAiCAB025192.
HPA046697.
HPA047245.
HPA061174.
MIMi609157. gene.
neXtProtiNX_Q15155.
OpenTargetsiENSG00000103512.
ENSG00000274779.
PharmGKBiPA134934458.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1948. Eukaryota.
ENOG410XTI0. LUCA.
GeneTreeiENSGT00390000000089.
HOGENOMiHOG000230623.
HOVERGENiHBG023764.
InParanoidiQ15155.
PhylomeDBiQ15155.
TreeFamiTF313696.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000103512-MONOMER.

Miscellaneous databases

ChiTaRSiNOMO1. human.
GeneWikiiNOMO1.
GenomeRNAii23420.
PROiQ15155.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000103512.
CleanExiHS_NOMO1.
ExpressionAtlasiQ15155. baseline and differential.
GenevisibleiQ15155. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
2.60.40.1120. 2 hits.
InterProiIPR013784. Carb-bd-like_fold.
IPR008969. CarboxyPept-like_regulatory.
IPR014766. CarboxyPept_regulatory_dom.
IPR013783. Ig-like_fold.
[Graphical view]
SUPFAMiSSF49452. SSF49452. 3 hits.
SSF49464. SSF49464. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNOMO1_HUMAN
AccessioniPrimary (citable) accession number: Q15155
Secondary accession number(s): P78421, Q8IW21, Q96DG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 156 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There are 3 copies of the NOMO gene on chromosome 16p12-p13: NOMO1, NOMO2 (AC Q5JPE7) and NOMO3 (AC P69849). All 3 are extremely similar, which makes their individual characterization difficult. Thus, most experiments probably do not discriminate between the different members. Moreover, it does not allow a clear view of which variant belongs to which of the 3 copies. The results reported in other entries may therefore apply for this protein.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.