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Q15147

- PLCB4_HUMAN

UniProt

Q15147 - PLCB4_HUMAN

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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4

Gene
PLCB4
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This form has a role in retina signal transduction.

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.

Cofactori

Calcium.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei328 – 3281 By similarity
Active sitei375 – 3751 By similarity

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: InterPro
  3. phospholipase C activity Source: ProtInc
  4. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. inositol phosphate metabolic process Source: Reactome
  2. intracellular signal transduction Source: InterPro
  3. lipid catabolic process Source: UniProtKB-KW
  4. lipid metabolic process Source: InterPro
  5. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium

Enzyme and pathway databases

ReactomeiREACT_150312. Synthesis of IP3 and IP4 in the cytosol.
REACT_15426. PLC beta mediated events.
REACT_18283. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-beta-4
Phospholipase C-beta-4
Short name:
PLC-beta-4
Gene namesi
Name:PLCB4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 20

Organism-specific databases

HGNCiHGNC:9059. PLCB4.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. dendrite Source: Ensembl
  3. nucleus Source: Ensembl
  4. postsynaptic density Source: Ensembl
  5. smooth endoplasmic reticulum Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Auriculocondylar syndrome 2 (ARCND2) [MIM:614669]: A craniofacial malformation syndrome characterized by variable mandibular anomalies, including mild to severe micrognathia, temporomandibular joint ankylosis, cleft palate, and a characteristic ear malformation that consists of separation of the lobule from the external ear, giving the appearance of a question mark (question-mark ear). Other frequently described features include prominent cheeks, cupped and posteriorly rotated ears, preauricular tags, and microstomia.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti329 – 3291N → T in ARCND2. 1 Publication
VAR_068559
Natural varianti621 – 6211R → C in ARCND2. 1 Publication
VAR_068560
Natural varianti621 – 6211R → H in ARCND2. 1 Publication
VAR_068561
Natural varianti623 – 6231Y → C in ARCND2. 1 Publication
VAR_068562
Natural varianti650 – 6501N → H in ARCND2. 1 Publication
VAR_068563

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi614669. phenotype.
Orphaneti137888. Auriculocondylar syndrome.
PharmGKBiPA33387.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 117511741-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-4PRO_0000088495Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine1 Publication
Modified residuei886 – 8861Phosphothreonine1 Publication

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ15147.
PaxDbiQ15147.
PeptideAtlasiQ5JYT3.
PRIDEiQ15147.

PTM databases

PhosphoSiteiQ15147.

Expressioni

Tissue specificityi

Preferentially expressed in the retina.

Gene expression databases

ArrayExpressiQ15147.
BgeeiQ15147.
GenevestigatoriQ15147.

Interactioni

Protein-protein interaction databases

BioGridi111348. 1 interaction.
IntActiQ15147. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ15147.
SMRiQ15147. Positions 6-855.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini313 – 463151PI-PLC X-boxAdd
BLAST
Domaini565 – 681117PI-PLC Y-boxAdd
BLAST
Domaini688 – 78699C2Add
BLAST

Sequence similaritiesi

Contains 1 C2 domain.

Phylogenomic databases

eggNOGiNOG149692.
HOVERGENiHBG053609.
KOiK05858.
OMAiSFTYMVA.
OrthoDBiEOG7WDN1N.
PhylomeDBiQ15147.
TreeFamiTF352235.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PfamiPF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PIRSFiPIRSF000956. PLC-beta. 1 hit.
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 isoformsi produced by alternative splicing. Align

Note: Additional isoforms seem to exist.

Isoform 2 (identifier: Q15147-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MAKPYEFNWQ KEVPSFLQEG AVFDRYEEES FVFEPNCLFK VDEFGFFLTW     50
RSEGKEGQVL ECSLINSIRS GAIPKDPKIL AALEAVGKSE NDLEGRIVCV 100
CSGTDLVNIS FTYMVAENPE VTKQWVEGLR SIIHNFRANN VSPMTCLKKH 150
WMKLAFMTNT NGKIPVRSIT RTFASGKTEK VIFQALKELG LPSGKNDEIE 200
PTAFSYEKFY ELTQKICPRT DIEDLFKKIN GDKTDYLTVD QLVSFLNEHQ 250
RDPRLNEILF PFYDAKRAMQ IIEMYEPDED LKKKGLISSD GFCRYLMSDE 300
NAPVFLDRLE LYQEMDHPLA HYFISSSHNT YLTGRQFGGK SSVEMYRQVL 350
LAGCRCVELD CWDGKGEDQE PIITHGKAMC TDILFKDVIQ AIKETAFVTS 400
EYPVILSFEN HCSKYQQYKM SKYCEDLFGD LLLKQALESH PLEPGRALPS 450
PNDLKRKILI KNKRLKPEVE KKQLEALRSM MEAGESASPA NILEDDNEEE 500
IESADQEEEA HPEFKFGNEL SADDLGHKEA VANSVKKGLV TVEDEQAWMA 550
SYKYVGATTN IHPYLSTMIN YAQPVKFQGF HVAEERNIHY NMSSFNESVG 600
LGYLKTHAIE FVNYNKRQMS RIYPKGGRVD SSNYMPQIFW NAGCQMVSLN 650
YQTPDLAMQL NQGKFEYNGS CGYLLKPDFM RRPDRTFDPF SETPVDGVIA 700
ATCSVQVISG QFLSDKKIGT YVEVDMYGLP TDTIRKEFRT RMVMNNGLNP 750
VYNEESFVFR KVILPDLAVL RIAVYDDNNK LIGQRILPLD GLQAGYRHIS 800
LRNEGNKPLS LPTIFCNIVL KTYVPDGFGD IVDALSDPKK FLSITEKRAD 850
QMRAMGIETS DIADVPSDTS KNDKKGKANT AKANVTPQSS SELRPTTTAA 900
LASGVEAKKG IELIPQVRIE DLKQMKAYLK HLKKQQKELN SLKKKHAKEH 950
STMQKLHCTQ VDKIVAQYDK EKSTHEKILE KAMKKKGGSN CLEMKKETEI 1000
KIQTLTSDHK SKVKEIVAQH TKEWSEMINT HSAEEQEIRD LHLSQQCELL 1050
KKLLINAHEQ QTQQLKLSHD RESKEMRAHQ AKISMENSKA ISQDKSIKNK 1100
AERERRVREL NSSNTKKFLE ERKRLAMKQS KEMDQLKKVQ LEHLEFLEKQ 1150
NEQAKEMQQM VKLEAEMDRR PATVV 1175
Length:1,175
Mass (Da):134,464
Last modified:December 5, 2001 - v3
Checksum:iAB2C8EB99EF57357
GO
Isoform 1 (identifier: Q15147-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-153: Missing.
     154-167: LAFMTNTNGKIPVR → MNNNWNVCFFLFCP

Show »
Length:1,022
Mass (Da):117,162
Checksum:i4A6A14188161A46C
GO
Isoform 3 (identifier: Q15147-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1154-1175: AKEMQQMVKLEAEMDRRPATVV → LLKSCHAVSQTQGEGDAADGEIGSRDGPQTSNSSMKLQNAN

Note: No experimental confirmation available.

Show »
Length:1,194
Mass (Da):136,106
Checksum:iE6A0912E517D182C
GO
Isoform 4 (identifier: Q15147-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     535-535: V → VKKASDDLEHENN

Note: No experimental confirmation available.

Show »
Length:1,187
Mass (Da):135,845
Checksum:i8EC5C7445E1052AA
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti21 – 211A → T.1 Publication
Corresponds to variant rs6077510 [ dbSNP | Ensembl ].
VAR_056694
Natural varianti329 – 3291N → T in ARCND2. 1 Publication
VAR_068559
Natural varianti621 – 6211R → C in ARCND2. 1 Publication
VAR_068560
Natural varianti621 – 6211R → H in ARCND2. 1 Publication
VAR_068561
Natural varianti623 – 6231Y → C in ARCND2. 1 Publication
VAR_068562
Natural varianti650 – 6501N → H in ARCND2. 1 Publication
VAR_068563
Natural varianti710 – 7101G → S.
Corresponds to variant rs6118603 [ dbSNP | Ensembl ].
VAR_056695

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 153153Missing in isoform 1. VSP_004721Add
BLAST
Alternative sequencei154 – 16714LAFMT…KIPVR → MNNNWNVCFFLFCP in isoform 1. VSP_004722Add
BLAST
Alternative sequencei535 – 5351V → VKKASDDLEHENN in isoform 4. VSP_055182
Alternative sequencei1154 – 117522AKEMQ…PATVV → LLKSCHAVSQTQGEGDAADG EIGSRDGPQTSNSSMKLQNA N in isoform 3. VSP_037818Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti447 – 4471A → P in AAB02027. 1 Publication
Sequence conflicti757 – 7571F → L in AAB02027. 1 Publication
Sequence conflicti787 – 7871L → P in AAB02027. 1 Publication
Sequence conflicti840 – 8401K → T in AAB02027. 1 Publication
Sequence conflicti902 – 9021A → P in AAB02027. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41349 mRNA. Translation: AAB02027.1.
AL121898 Genomic DNA. No translation available.
AL121909 Genomic DNA. No translation available.
AL031652, AL023805 Genomic DNA. Translation: CAI42213.1.
AL023805, AL031652 Genomic DNA. Translation: CAI43087.1.
AL031652, AL023805 Genomic DNA. Translation: CAI42218.2.
AL023805, AL031652 Genomic DNA. Translation: CAI43092.2.
BC117458 mRNA. Translation: AAI17459.1.
BC143868 mRNA. Translation: AAI43869.1.
CCDSiCCDS13104.1. [Q15147-4]
CCDS13105.1. [Q15147-1]
RefSeqiNP_000924.3. NM_000933.3. [Q15147-4]
NP_001166117.1. NM_001172646.1.
NP_877949.2. NM_182797.2. [Q15147-1]
XP_006723633.1. XM_006723570.1. [Q15147-4]
XP_006723634.1. XM_006723571.1.
XP_006723635.1. XM_006723572.1. [Q15147-1]
UniGeneiHs.472101.

Genome annotation databases

EnsembliENST00000278655; ENSP00000278655; ENSG00000101333. [Q15147-1]
ENST00000334005; ENSP00000334105; ENSG00000101333. [Q15147-4]
ENST00000378473; ENSP00000367734; ENSG00000101333.
ENST00000378493; ENSP00000367754; ENSG00000101333. [Q15147-1]
ENST00000378501; ENSP00000367762; ENSG00000101333. [Q15147-4]
ENST00000414679; ENSP00000390616; ENSG00000101333.
GeneIDi5332.
KEGGihsa:5332.
UCSCiuc002wnh.3. human. [Q15147-2]
uc010gbw.1. human. [Q15147-1]
uc010gbx.3. human.
uc021wam.1. human. [Q15147-4]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L41349 mRNA. Translation: AAB02027.1 .
AL121898 Genomic DNA. No translation available.
AL121909 Genomic DNA. No translation available.
AL031652 , AL023805 Genomic DNA. Translation: CAI42213.1 .
AL023805 , AL031652 Genomic DNA. Translation: CAI43087.1 .
AL031652 , AL023805 Genomic DNA. Translation: CAI42218.2 .
AL023805 , AL031652 Genomic DNA. Translation: CAI43092.2 .
BC117458 mRNA. Translation: AAI17459.1 .
BC143868 mRNA. Translation: AAI43869.1 .
CCDSi CCDS13104.1. [Q15147-4 ]
CCDS13105.1. [Q15147-1 ]
RefSeqi NP_000924.3. NM_000933.3. [Q15147-4 ]
NP_001166117.1. NM_001172646.1.
NP_877949.2. NM_182797.2. [Q15147-1 ]
XP_006723633.1. XM_006723570.1. [Q15147-4 ]
XP_006723634.1. XM_006723571.1.
XP_006723635.1. XM_006723572.1. [Q15147-1 ]
UniGenei Hs.472101.

3D structure databases

ProteinModelPortali Q15147.
SMRi Q15147. Positions 6-855.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111348. 1 interaction.
IntActi Q15147. 1 interaction.

PTM databases

PhosphoSitei Q15147.

Proteomic databases

MaxQBi Q15147.
PaxDbi Q15147.
PeptideAtlasi Q5JYT3.
PRIDEi Q15147.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000278655 ; ENSP00000278655 ; ENSG00000101333 . [Q15147-1 ]
ENST00000334005 ; ENSP00000334105 ; ENSG00000101333 . [Q15147-4 ]
ENST00000378473 ; ENSP00000367734 ; ENSG00000101333 .
ENST00000378493 ; ENSP00000367754 ; ENSG00000101333 . [Q15147-1 ]
ENST00000378501 ; ENSP00000367762 ; ENSG00000101333 . [Q15147-4 ]
ENST00000414679 ; ENSP00000390616 ; ENSG00000101333 .
GeneIDi 5332.
KEGGi hsa:5332.
UCSCi uc002wnh.3. human. [Q15147-2 ]
uc010gbw.1. human. [Q15147-1 ]
uc010gbx.3. human.
uc021wam.1. human. [Q15147-4 ]

Organism-specific databases

CTDi 5332.
GeneCardsi GC20P009024.
HGNCi HGNC:9059. PLCB4.
MIMi 600810. gene.
614669. phenotype.
neXtProti NX_Q15147.
Orphaneti 137888. Auriculocondylar syndrome.
PharmGKBi PA33387.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG149692.
HOVERGENi HBG053609.
KOi K05858.
OMAi SFTYMVA.
OrthoDBi EOG7WDN1N.
PhylomeDBi Q15147.
TreeFami TF352235.

Enzyme and pathway databases

Reactomei REACT_150312. Synthesis of IP3 and IP4 in the cytosol.
REACT_15426. PLC beta mediated events.
REACT_18283. G alpha (q) signalling events.

Miscellaneous databases

ChiTaRSi PLCB4. human.
GeneWikii PLCB4.
GenomeRNAii 5332.
NextBioi 20648.
PROi Q15147.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q15147.
Bgeei Q15147.
Genevestigatori Q15147.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
2.30.29.30. 1 hit.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR011993. PH_like_dom.
IPR001192. PI-PLC_fam.
IPR016280. PLC-beta.
IPR009535. PLC-beta_CS.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
Pfami PF00168. C2. 1 hit.
PF06631. DUF1154. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PIRSFi PIRSF000956. PLC-beta. 1 hit.
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 2 hits.
PROSITEi PS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA sequence and gene locus of the human retinal phosphoinositide-specific phospholipase-C beta 4 (PLCB4)."
    Alvarez R.A., Ghalayini A.J., Xu P., Hardcastle A., Bhattacharya S., Rao P.N., Pettenati M.J., Anderson R.E., Baehr W.
    Genomics 29:53-61(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  2. "The DNA sequence and comparative analysis of human chromosome 20."
    Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R., Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L., Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P., Bird C.P., Blakey S.E.
    , Bridgeman A.M., Brown A.J., Buck D., Burrill W.D., Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G., Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E., Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D., Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P., Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E., Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J., Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D., Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S., Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D., Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A., Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T., Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I., Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M., Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D., Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M., Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A., Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L., Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L., Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.
    Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), VARIANT THR-21.
    Tissue: Brain.
  4. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 2-11; 79-88; 154-163; 181-195; 220-227; 255-266; 366-377; 435-455; 516-528; 577-586; 606-717; 762-780; 786-797; 822-847; 854-871; 883-908; 910-918; 1023-1039 AND 1139-1149, CLEAVAGE OF INITIATOR METHIONINE, ACETYLATION AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Ovarian carcinoma.
  5. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
    Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
    Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-886, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  6. Cited for: VARIANTS ARCND2 THR-329; HIS-621; CYS-621; CYS-623 AND HIS-650.

Entry informationi

Entry nameiPLCB4_HUMAN
AccessioniPrimary (citable) accession number: Q15147
Secondary accession number(s): B7ZLK6
, E2QRH8, Q17R56, Q5JYS8, Q5JYS9, Q5JYT0, Q5JYT3, Q5JYT4, Q9BQW5, Q9BQW6, Q9BQW8, Q9UJQ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: December 5, 2001
Last modified: September 3, 2014
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi