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Protein
Submitted name:

Polycystic kidney disease-associated protein

Gene

PKD1

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Protein predictedi

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
Polycystic kidney disease-associated proteinImported
Gene namesi
Name:PKD1Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei2411 – 2431HelicalSequence analysisAdd BLAST21
Transmembranei2617 – 2638HelicalSequence analysisAdd BLAST22
Transmembranei2658 – 2680HelicalSequence analysisAdd BLAST23
Transmembranei2891 – 2913HelicalSequence analysisAdd BLAST23
Transmembranei2919 – 2938HelicalSequence analysisAdd BLAST20
Transmembranei3006 – 3025HelicalSequence analysisAdd BLAST20
Transmembranei3228 – 3251HelicalSequence analysisAdd BLAST24
Transmembranei3271 – 3294HelicalSequence analysisAdd BLAST24
Transmembranei3314 – 3335HelicalSequence analysisAdd BLAST22
Transmembranei3361 – 3383HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_500418324624 – 3638Sequence analysisAdd BLAST3615

Proteomic databases

PeptideAtlasiQ15142.
PRIDEiQ15142.

Structurei

3D structure databases

ProteinModelPortaliQ15142.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini232 – 292PKDInterPro annotationAdd BLAST61
Domaini348 – 464C-type lectinInterPro annotationAdd BLAST117
Domaini673 – 735PKDInterPro annotationAdd BLAST63
Domaini765 – 844PKDInterPro annotationAdd BLAST80
Domaini848 – 896PKDInterPro annotationAdd BLAST49
Domaini917 – 974PKDInterPro annotationAdd BLAST58
Domaini999 – 1064PKDInterPro annotationAdd BLAST66
Domaini1090 – 1150PKDInterPro annotationAdd BLAST61
Domaini1168 – 1205PKDInterPro annotationAdd BLAST38
Domaini1252 – 1338PKDInterPro annotationAdd BLAST87
Domaini1364 – 1423PKDInterPro annotationAdd BLAST60
Domaini1434 – 1500PKDInterPro annotationAdd BLAST67
Domaini1498 – 2169REJInterPro annotationAdd BLAST672
Domaini2348 – 2397GPSInterPro annotationAdd BLAST50
Domaini2454 – 2569PLATInterPro annotationAdd BLAST116

Keywords - Domaini

Leucine-rich repeatSAAS annotation, RepeatSAAS annotation, SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

HOGENOMiHOG000168445.
HOVERGENiHBG049412.

Family and domain databases

Gene3Di2.60.40.670. 10 hits.
2.60.60.20. 1 hit.
3.10.100.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000483. Cys-rich_flank_reg_C.
IPR000203. GPS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR000434. PC1.
IPR022409. PKD/Chitinase_dom.
IPR002859. PKD/REJ-like.
IPR013122. PKD1_2_channel.
IPR000601. PKD_dom.
IPR001024. PLAT/LH2_dom.
IPR014010. REJ_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF13855. LRR_8. 1 hit.
PF00801. PKD. 10 hits.
PF08016. PKD_channel. 1 hit.
PF01477. PLAT. 1 hit.
PF02010. REJ. 1 hit.
[Graphical view]
PRINTSiPR00500. POLYCYSTIN1.
SMARTiSM00034. CLECT. 1 hit.
SM00303. GPS. 1 hit.
SM00308. LH2. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00089. PKD. 11 hits.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 11 hits.
SSF49723. SSF49723. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS50221. GPS. 1 hit.
PS51450. LRR. 2 hits.
PS50093. PKD. 11 hits.
PS50095. PLAT. 1 hit.
PS51111. REJ. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q15142-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPAAPARLA LALGLGLWLG ALAGGPGRGC GPCEPPCLCG PAPGAACRVN
60 70 80 90 100
CSGRGLRTLG PALRIPADAT ALTAMAKADG DVKKYGSKRG ALALTHGHSL
110 120 130 140 150
LRDVSHNLLR ALDVGLLANL SALAELDISN NKISTLEEGI FANLFNLSEI
160 170 180 190 200
NLSGNPFECD CGLAWLPRWA EEQQVRVVQP EAATCAGPGS LAGQPLLGIP
210 220 230 240 250
LLDSGCGATL VGPHGPLASG QLAAFHIAAP LPVTATRWDF GDGSAEVDAA
260 270 280 290 300
GPAASHRYVL PGRYHVTAVL ALGAGSALLG TDVQVEAAPA ALELVCPSSV
310 320 330 340 350
QSDESLDLSI QNRGGSGLEA AYSIVALGEE PARAVHPLCP SDTEIFPGNG
360 370 380 390 400
HCYRLVVEKA AWLQAQEQCQ AWAGAALAMV DSPAVQRFLV SRVTRSLDVW
410 420 430 440 450
IGFSTVQGVE VGPAPQGEAF SLESCQNWLP GEPHPATAEH CVRLGPTGWC
460 470 480 490 500
NTDLCSAPHS YVCELQPGGP VQDAENLLVG APSGDLQGPL TPLAQQDGLS
510 520 530 540 550
APHEPVEAGM GSVELRRPPA HQVMVFPGLR LSREAFLTTA EFGTQELRRP
560 570 580 590 600
AQLRLQVYRL LSTAGTPENG SEPESRSPDN RTQLAPACMP GGRWCPGANI
610 620 630 640 650
CLPLDASCHP QACANGCTEG EHVVDVVVEN SASRANLSLR VTAEEPICGL
660 670 680 690 700
RATPSPEARV LQGVLVRYSP VVEAGSDMVF RWTINDKQSL TFQNVVFNVI
710 720 730 740 750
YQSAAVFKLS LTASNHVSNV TVNYNVTVER MNRMQGLQVS TVPAVLSPNA
760 770 780 790 800
TLALTAGVLV DSAVEVAFLW TFGDGEQALH QFQPPYNESF PVPDPSVAQV
810 820 830 840 850
LVEHNVMHTY AAPGEYLLTV LASNAFENRT QQVPVSVRAS LPSVAVGVSD
860 870 880 890 900
GVLSQPAANH TYASRGTYHV RLEVNNTVSG AAAQADVRVF EELRGLSVDM
910 920 930 940 950
SLAVEQGAPV VVSAAVQTGD NITWTFDMGD GTVLSGPEAT VEHVYLRAQN
960 970 980 990 1000
CTVTVGAASP AGHLARSLHV LVFVLEVLRV EPAACIPTQP DARLTAYVTG
1010 1020 1030 1040 1050
NPAHYLFDWT FGDGSSNTTV RGCPTVTHNF TRSGTFPLAL VLSSRVNRAH
1060 1070 1080 1090 1100
YFTSICVEPE VGNVTLQPER QFVQLGDEAW LVACAWPPFP YRYTWDFGTE
1110 1120 1130 1140 1150
EAAPTRARGP EVTFIYRDPG SYLVTVTASN NISAANDSAL VEVQEPVLVT
1160 1170 1180 1190 1200
SIKVNGSLGL ELQQPYLFSA VGRGRPASYL WDLGDGGWLE GPEVTHAYNS
1210 1220 1230 1240 1250
TGDFTGPGPG RQRQRLLAHR LEAGTYHVQL RATNMLGSAW ADCTMDFVEP
1260 1270 1280 1290 1300
VGWLMVAASP NPAAVNKSVT LSAELAGGSG VVYTWSLEEG LSWETSEPFT
1310 1320 1330 1340 1350
THSFPTPGLH LVTMTAGNPL GSANATVEVD VQVPVSGLSI RASEPGGSFV
1360 1370 1380 1390 1400
AAGSSVPFWG QLATGTNVSW CWAVPGGSSK RGPHVTMVFP DAGTFSIRLN
1410 1420 1430 1440 1450
ASNAVSWVSA TYNLTAEEPI VGLVLWASSK VVAPGQLVHF QILLAAGSAV
1460 1470 1480 1490 1500
TFRLQDTDEP RAEHSYLRPG DYRVQVNASN LVSFFVAQAT VTVQVLACRE
1510 1520 1530 1540 1550
PEVDVVLPLQ VLMRRSQRNY LEAHVDLRDC VTYQTEYRWE VYRTASCQRP
1560 1570 1580 1590 1600
GRPARVALPG VDVSRPRLVL PRLALPVGHY CFVFVVSFGD TPLTQSIQAN
1610 1620 1630 1640 1650
VTVAPERLVP IIEGGSYRVW SDTRDLVLDG SESYDPNLED GDQTPLSFHW
1660 1670 1680 1690 1700
ACVASTQREA GGCALNFGPR GSSTVTIPRE RLAAGVEYTF SLTVWKAGRK
1710 1720 1730 1740 1750
EEATNQTVLI RSGRVPIVSL ECVSCKAQAV YEVSRSSYVY LEGRCLNCSS
1760 1770 1780 1790 1800
GSKRGRWAAR TFSNKTLVLD ETTTSTGSAG MRLVLRRGVL RDGEGYTFTL
1810 1820 1830 1840 1850
TVLGRSGEEE GCASIRLSPN RPPLGGSCRL FPLGAVHALT TKVHFECTGW
1860 1870 1880 1890 1900
HDAEDAGAPL VYALLLRRCR QGHCEEFCVY KGSLSSYGAV LPPGFRPHFE
1910 1920 1930 1940 1950
VGLAVVVQDQ LGAAVVALNR SLAITLPEPN GSATGLTVWL HGLTASVLPG
1960 1970 1980 1990 2000
LLRQADPQHV IEYSLALVTV LNEHRAQIRK NITETLVSLR VHTVDDIQQI
2010 2020 2030 2040 2050
AAALAQCMGP SRELVCRSCL KQTLHKLEAM MLILQAETTA GTVTPTAIGD
2060 2070 2080 2090 2100
SILNITGDLI HLASSDVRAP QPSELGAESP SRMVASQAYN LTSALMRILM
2110 2120 2130 2140 2150
RSRVLNEEPL TLAGEEIVAQ GKRSDPRSLL CYGGAPGPGC HFSIPEAFSG
2160 2170 2180 2190 2200
ALANLSDVVQ LIFLVDSNPF PFGYISNYTV STKVASMAFQ TQAGAQIPIE
2210 2220 2230 2240 2250
RLASERAITV KVPNNSDWAA RGHRSSANSA NSVVVQPQAS VGAVVTLDSS
2260 2270 2280 2290 2300
NPAAGLHLQL NYTLLDGHYL SEEPEPYLAV YLHSEPRPNE HNCSASRRIR
2310 2320 2330 2340 2350
PESLQGADHR PYTFFISPGS RDPAGSYHLN LSSHFRWSAL QVSVGLYTSL
2360 2370 2380 2390 2400
CQYFSEEDMV WRTEGLLPLE ETSPRQAVCL TRHLTAFGAS LFVPPSHVRF
2410 2420 2430 2440 2450
VFPEPTADVN YIVMLTCAVC LVTYMVMAAI LHKLDQLDAS RGRAIPFCGQ
2460 2470 2480 2490 2500
RGRFKYEILV KTGWGRGSGT TAHVGIMLYG VDSRSGHRHL DGDRAFHRNS
2510 2520 2530 2540 2550
LDIFRIATPH SLGSVWKIRV WHDNKGLSPA WFLQHVIVRD LQTARSAFFL
2560 2570 2580 2590 2600
VNDWLSVETE ANGGLVEKEV LAASDAALLR FRRLLVAELQ RGFFDKHIWL
2610 2620 2630 2640 2650
SIWDRPPRSR FTRIQRATCC VLLICLFLGA NAVWYGAVGD SAYSTGHVSR
2660 2670 2680 2690 2700
LSPLSVDTVA VGLVSSVVVY PVYLAILFLF RMSRSKVAGS PSPTPAGQQV
2710 2720 2730 2740 2750
LDIDSCLDSS VLDSSFLTFS GLHAEAFVGQ MKSDLFLDDS KSLVCWPSGE
2760 2770 2780 2790 2800
GTLSWPDLLS DPSIVGSNLR QLARGQAGHG LGPEEDGFSL ASPYSPAKSF
2810 2820 2830 2840 2850
SASDEDLIQQ VLAEGVSSPA PTQDTHMETD LLSSLSSTPG EKTETLALQR
2860 2870 2880 2890 2900
LGELGPPSPG LNWEQPQAAR LSRTGLVEGL RKRLLPAWCA SLAHGLSLLL
2910 2920 2930 2940 2950
VAVAVAVSGW VGASFPPGVS VAWLLSSSAS FLASFLGWEP LKVLLEALYF
2960 2970 2980 2990 3000
SLVAKRLHPD EDDTLVESPA VTPVSARVPR VRPPHGFALF LAKEEARKVK
3010 3020 3030 3040 3050
RLHGMLRSLL VYMLFLLVTL LASYGDASCH GHAYRLQSAI KQELHSRAFL
3060 3070 3080 3090 3100
AITRSEELWP WMAHVLLPYV HGNQSSPELG PPRLRQVRLQ EALYPDPPGP
3110 3120 3130 3140 3150
RVHTCSAAGG FSTSDYDVGW ESPHNGSGTW AYSAPDLLGA WSWGSCAVYD
3160 3170 3180 3190 3200
SGGYVQELGL SLEESRDRLR FLQLHNWLDN RSRAVFLELT RYSPAVGLHA
3210 3220 3230 3240 3250
AVTLRLEFPA AGRALAALSV RPFALRRLSA GLSLPLLTSV CLLLFAVHFA
3260 3270 3280 3290 3300
VAEARTWHRE GRWRVLRLGA WARWLLVALT AATALVRLAQ LGAADRQWTR
3310 3320 3330 3340 3350
FVRGRPRRFT SFDQVAQLSS AARGLAASLL FLLLVKAAQQ LRFVRQWSVF
3360 3370 3380 3390 3400
GKTLCRALPE LLGVTLGLVV LGVAYAQLAI LLVSSCVDSL WSVAQALLVL
3410 3420 3430 3440 3450
CPGTGLSTLC PAESWHLSPL LCVGLWALRL WGALRLGAVI LRWRYHALRG
3460 3470 3480 3490 3500
ELYRPAWEPQ DYEMVELFLR RLRLWMGLSK VKEFRHKVRF EGMEPLPSRS
3510 3520 3530 3540 3550
SRGSKVSPDV PPPSAGSDAS HPSTSSSQLD GLSVSLGRLG TRCEPEPSRL
3560 3570 3580 3590 3600
QAVFEALLTQ FDRLNQATED VYQLEQQLHS LQGRRSSRAP AGSSRGPSPG
3610 3620 3630
LRPALPSRLA RASRGVDLAT GPSRTPLRAK NKVHPSST
Length:3,638
Mass (Da):392,186
Last modified:November 1, 1996 - v1
Checksum:i8267F06B5E04B0D1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39891 Genomic DNA. Translation: AAB59488.1.
UniGeneiHs.75813.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L39891 Genomic DNA. Translation: AAB59488.1.
UniGeneiHs.75813.

3D structure databases

ProteinModelPortaliQ15142.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PeptideAtlasiQ15142.
PRIDEiQ15142.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

H-InvDBHIX0038632.

Phylogenomic databases

HOGENOMiHOG000168445.
HOVERGENiHBG049412.

Family and domain databases

Gene3Di2.60.40.670. 10 hits.
2.60.60.20. 1 hit.
3.10.100.10. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR001304. C-type_lectin-like.
IPR016186. C-type_lectin-like/link.
IPR016187. CTDL_fold.
IPR000483. Cys-rich_flank_reg_C.
IPR000203. GPS.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
IPR000372. LRRNT.
IPR000434. PC1.
IPR022409. PKD/Chitinase_dom.
IPR002859. PKD/REJ-like.
IPR013122. PKD1_2_channel.
IPR000601. PKD_dom.
IPR001024. PLAT/LH2_dom.
IPR014010. REJ_dom.
[Graphical view]
PfamiPF00059. Lectin_C. 1 hit.
PF13855. LRR_8. 1 hit.
PF00801. PKD. 10 hits.
PF08016. PKD_channel. 1 hit.
PF01477. PLAT. 1 hit.
PF02010. REJ. 1 hit.
[Graphical view]
PRINTSiPR00500. POLYCYSTIN1.
SMARTiSM00034. CLECT. 1 hit.
SM00303. GPS. 1 hit.
SM00308. LH2. 1 hit.
SM00369. LRR_TYP. 1 hit.
SM00082. LRRCT. 1 hit.
SM00013. LRRNT. 1 hit.
SM00089. PKD. 11 hits.
[Graphical view]
SUPFAMiSSF49299. SSF49299. 11 hits.
SSF49723. SSF49723. 1 hit.
SSF52058. SSF52058. 1 hit.
SSF56436. SSF56436. 1 hit.
PROSITEiPS50041. C_TYPE_LECTIN_2. 1 hit.
PS50221. GPS. 1 hit.
PS51450. LRR. 2 hits.
PS50093. PKD. 11 hits.
PS50095. PLAT. 1 hit.
PS51111. REJ. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiQ15142_HUMAN
AccessioniPrimary (citable) accession number: Q15142
Entry historyi
Integrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: November 30, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.