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Protein
Submitted name:

Protein kinase A-alpha

Gene

PRKACA

Organism
Homo sapiens (Human)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Keywordsi

Molecular functionKinase, Serine/threonine-protein kinaseUniRule annotation, Transferase
LigandATP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Submitted name:
Protein kinase A-alphaImported
Submitted name:
cAMP-dependent protein kinase catalytic subunit alphaImported
Gene namesi
Name:PRKACAImported
Synonyms:KIN27Imported
OrganismiHomo sapiens (Human)Imported
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000072062.13
HGNCiHGNC:9380 PRKACA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000072062

PTM / Processingi

Proteomic databases

MaxQBiQ15136
PeptideAtlasiQ15136

Expressioni

Gene expression databases

BgeeiENSG00000072062

Structurei

3D structure databases

SMRiQ15136
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 207Protein kinaseInterPro annotationAdd BLAST181

Sequence similaritiesi

Belongs to the protein kinase superfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG0616 Eukaryota
ENOG410XPQQ LUCA
GeneTreeiENSGT00810000125385
HOVERGENiHBG108317

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
IPR017441 Protein_kinase_ATP_BS
IPR008271 Ser/Thr_kinase_AS
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SMARTiView protein in SMART
SM00220 S_TKc, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS00107 PROTEIN_KINASE_ATP, 1 hit
PS50011 PROTEIN_KINASE_DOM, 1 hit
PS00108 PROTEIN_KINASE_ST, 1 hit

Sequencei

Sequence statusi: Fragment.

Q15136-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
EFLAKAKEDF LKKWESPAQN TAHLDQFERI KTLGTGSFGR VMLVKHKETG
60 70 80 90 100
NHYAMKILDK QKVVKLKQIE HTLNEKRILQ AVNFPFLVKL EFSFKDNSNL
110 120 130 140 150
YMVMEYVPGG EMFSHLRRIG RFSEPHARFY AAQIVLTFEY LHSLDLIYRD
160 170 180 190 200
LKPENLLIDQ QGYIQVTDFG FAKRVKGRTW TLCGTPEYLA PEIILSKVGA

SPALPFP
Length:207
Mass (Da):23,954
Last modified:November 1, 1996 - v1
Checksum:iC901E1EA7437EA58
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC022098 Genomic DNA No translation available.
M80335 mRNA Translation: AAA60094.1
PIRiA38143
UniGeneiHs.631630

Genome annotation databases

EnsembliENST00000593092; ENSP00000466289; ENSG00000072062
UCSCiuc060uly.1 human

Similar proteinsi

Entry informationi

Entry nameiQ15136_HUMAN
AccessioniPrimary (citable) accession number: Q15136
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: April 25, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
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Main funding by: National Institutes of Health