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Reviewed, UniProtKB/Swiss-Prot Q15131 (CDK10_HUMAN)

Last modified November 3, 2009. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Cell division protein kinase 10
    EC=2.7.11.22
Alternative name(s):
    Serine/threonine-protein kinase PISSLRE
Gene names
Name: CDK10
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at protein level.

General annotation (Comments)

Catalytic activity

ATP + a protein = ADP + a phosphoprotein.

Sequence similarities

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Contains 1 protein kinase domain.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

ETS2P150362EBI-1646959,EBI-1646991

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q15131-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q15131-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
Note: No experimental confirmation available.
Isoform 3 (identifier: Q15131-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     306-311: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q15131-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-71: Missing.
     329-360: PCEPELMPTFPHHRNKRAAPATSEGQSKRCKP → RLPISGVCEGCREPG

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Cell division protein kinase 10
PRO_0000085809

Regions

Domain39 – 323285Protein kinase
Nucleotide binding45 – 539ATP By similarity

Sites

Active site1631Proton acceptor By similarity
Binding site681ATP By similarity

Amino acid modifications

Modified residue1961Phosphothreonine Ref.9 Ref.10 Ref.11

Natural variations

Alternative sequence1 – 7171Missing in isoform 2, isoform 3 and isoform 4.
VSP_021642
Alternative sequence306 – 3116Missing in isoform 3.
VSP_021643
Alternative sequence329 – 36032PCEPE…KRCKP → RLPISGVCEGCREPG in isoform 4.
VSP_021644
Natural variant961P → L
VAR_041983
Natural variant1681N → S
VAR_041984
Natural variant3421R → H
VAR_041985
Natural variant3581C → Y
VAR_041986

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 1, 1996. Version 1.
Checksum: 25B28560961103F4

FASTA36041,038
        10         20         30         40         50         60 
MAEPDLECEQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY GIVYRARDTQ 

        70         80         90        100        110        120 
TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE LKEVVVGNHL ESIFLVMGYC 

       130        140        150        160        170        180 
EQDLASLLEN MPTPFSEAQV KCIVLQVLRG LQYLHRNFII HRDLKVSNLL MTDKGCVKTA 

       190        200        210        220        230        240 
DFGLARAYGV PVKPMTPKVV TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHRPLLP 

       250        260        270        280        290        300 
GTSEIHQIDL IVQLLGTPSE NIWPGFSKLP LVGQYSLRKQ PYNNLKHKFP WLSEAGLRLL 

       310        320        330        340        350        360 
HFLFMYDPKK RATAGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAT SEGQSKRCKP 

« Hide

Isoform 2.

Checksum: 4C1854D5E1858B32
Show »

FASTA28932,731
Isoform 3.

Checksum: C6B5F44BF84F9B88
Show »

FASTA28331,944
Isoform 4.

Checksum: 6F30BB76F69F772D
Show »

FASTA27230,702

References

« Hide 'large scale' references
[1]"PISSLRE, a human novel CDC2-related protein kinase."
Grana X., Claudio P.P., De Luca A., Sang N., Giordano A.
Oncogene 9:2097-2103(1994) [PubMed: 8208557] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4).
[2]Grana X., Claudio P.P., De Luca A., Sang N., Giordano A.
Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases
Cited for: SEQUENCE REVISION.
[3]"Molecular cloning of PISSLRE, a novel putative member of the cdk family of protein serine/threonine kinases."
Brambilla R., Draetta G.
Oncogene 9:3037-3041(1994) [PubMed: 8084611] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[4]"The PISSLRE gene: structure, exon skipping, and exclusion as tumor suppressor in breast cancer."
Crawford J., Ianzano L., Savino M., Whitmore S., Cleton-Jansen A.-M., Settasatiani C., D'Apolito M., Seshadri R., Pronk J.C., Auerbach A.D., Verlander P.C., Mathew C.G., Tipping A.J., Doggett N.A., Zelante L., Callen D.F., Savoia A.
Genomics 56:90-97(1999) [PubMed: 10036189] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[5]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Colon.
[6]Bechtel S., Schupp I., Duda A., Wellenreuther R., Mehrle A., Ruschke V., Poustka A., Wiemann S.
Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3).
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4).
Tissue: Colon and Lung.
[9]"Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry."
Wissing J., Jaensch L., Nimtz M., Dieterich G., Hornberger R., Keri G., Wehland J., Daub H.
Mol. Cell. Proteomics 6:537-547(2007) [PubMed: 17192257] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-196, MASS SPECTROMETRY.
[10]"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-196, MASS SPECTROMETRY.
[11]"A quantitative atlas of mitotic phosphorylation."
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-196, MASS SPECTROMETRY.
[12]"Patterns of somatic mutation in human cancer genomes."
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G. expand/collapse author list , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
Nature 446:153-158(2007) [PubMed: 17344846] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-96; SER-168; HIS-342 AND TYR-358.

Cross-references

Sequence databases

L33264 mRNA. Translation: AAA60092.2.
X78342 mRNA. Translation: CAA55137.1.
AJ010341 expand/collapse EMBL AC list , AJ010342, AJ010343, AJ010344 Genomic DNA. Translation: CAB37619.1.
AM392903 mRNA. Translation: CAL37781.1.
AK296631 mRNA. Translation: BAH12406.1.
AM393177 mRNA. Translation: CAL38055.1.
AM393204 mRNA. Translation: CAL38082.1.
CH471184 Genomic DNA. Translation: EAW66704.1.
BC017342 mRNA. Translation: AAH17342.1.
BC025301 mRNA. Translation: AAH25301.1.
IPIIPI00014873.
IPI00639889.
IPI00642595.
IPI00788960.
PIRS49330.
RefSeqNP_001092003.2.
NP_001153839.1.
NP_443713.2.
NP_443714.3.
UniGeneHs.699177

3D structure databases

HSSPHSSP built from PDB template 1H00 based on UniProtKB P24941.
ModBaseSearch...

Protein-protein interaction databases

IntActQ15131. 2 interactions.
STRINGQ15131.

PTM databases

PhosphoSiteQ15131.

Proteomic databases

PRIDEQ15131.

Genome annotation databases

EnsemblENST00000331006; ENSP00000329957; ENSG00000185324; Homo sapiens. [Genome view]
ENST00000353379; ENSP00000338673; ENSG00000185324; Homo sapiens. [Genome view]
ENST00000378277; ENSP00000367526; ENSG00000185324; Homo sapiens. [Genome view]
ENST00000393082; ENSP00000376797; ENSG00000185324; Homo sapiens. [Genome view]
ENST00000437260; ENSP00000404540; ENSG00000185324; Homo sapiens. [Genome view]
GeneID8558.
KEGGhsa:8558.
UCSCuc002fod.1. human.
uc002fof.1. human.
uc002foh.2. human.
uc010cio.1. human.

Organism-specific databases

CTD8558.
GeneCardsGC16P088280.
H-InvDBHIX0013366.
HGNCHGNC:1770. CDK10.
MIM603464. gene.
PharmGKBPA26307.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ15131.
HOVERGENQ15131.
OMAMEYCEQD.

Enzyme and pathway databases

BRENDA2.7.11.22. 247.

Gene expression databases

ArrayExpressQ15131.
BgeeQ15131.
CleanExHS_CDK10.
GenevestigatorQ15131.
GermOnlineENSG00000185324. Homo sapiens.

Family and domain databases

InterProIPR000719. Prot_kinase_core.
IPR017441. Protein_kinase_ATP_BS.
IPR017442. Se/Thr_pkinase-rel.
IPR008271. Ser_thr_pkin_AS.
IPR002290. Ser_thr_pkinase.
[Graphical view]
PfamPF00069. Pkinase. 1 hit.
[Graphical view]
ProDomPD000001. Prot_kinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTSM00220. S_TKc. 1 hit.
[Graphical view]
PROSITEPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio32077.
SOURCESearch...

Entry information

Entry nameCDK10_HUMAN
AccessionPrimary (citable) accession number: Q15131
Secondary accession number(s): B7Z420 expand/collapse secondary AC list , Q0VGZ7, Q15130, Q6PJC0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: November 1, 1996
Last modified: November 3, 2009
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents